PAX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)8.71378023
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060528.70649565
3vagina development (GO:0060068)6.94275639
4muscle filament sliding (GO:0030049)6.45684743
5actin-myosin filament sliding (GO:0033275)6.45684743
6muscle cell fate commitment (GO:0042693)6.10778369
7branch elongation of an epithelium (GO:0060602)5.74165112
8branching involved in prostate gland morphogenesis (GO:0060442)5.71239764
9positive regulation of nitric-oxide synthase activity (GO:0051000)5.69429658
10female genitalia development (GO:0030540)5.66025656
11skeletal muscle contraction (GO:0003009)5.57709118
12uterus development (GO:0060065)5.53927398
13prostate gland growth (GO:0060736)5.49527870
14regulation of skeletal muscle contraction (GO:0014819)5.42265898
15actin-mediated cell contraction (GO:0070252)5.39776103
16intracellular estrogen receptor signaling pathway (GO:0030520)5.28945997
17axis elongation (GO:0003401)5.23344970
18cellular response to estradiol stimulus (GO:0071392)4.75078809
19lung epithelium development (GO:0060428)4.60565561
20muscle organ morphogenesis (GO:0048644)4.51903675
21sarcoplasmic reticulum calcium ion transport (GO:0070296)4.46721349
22mammary gland epithelial cell proliferation (GO:0033598)4.40988390
23response to inactivity (GO:0014854)4.39076203
24organ induction (GO:0001759)4.19356291
25regulation of somitogenesis (GO:0014807)4.11430048
26neuromuscular synaptic transmission (GO:0007274)4.06182165
27regulation of retinoic acid receptor signaling pathway (GO:0048385)4.06027925
28sarcomere organization (GO:0045214)4.02822072
29neuron fate determination (GO:0048664)3.97183423
30actin filament-based movement (GO:0030048)3.93235986
31* dorsal/ventral neural tube patterning (GO:0021904)3.91067337
32dendritic spine morphogenesis (GO:0060997)3.89358724
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.87606447
34axon extension involved in axon guidance (GO:0048846)3.87606447
35somite development (GO:0061053)3.85901169
36mitotic sister chromatid cohesion (GO:0007064)3.84588413
37positive regulation of monooxygenase activity (GO:0032770)3.83295058
38regulation of extracellular matrix disassembly (GO:0010715)3.78575634
39response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.74974518
40axonal fasciculation (GO:0007413)3.74908186
41nuclear pore complex assembly (GO:0051292)3.74009357
42cell proliferation in forebrain (GO:0021846)3.72113180
43postsynaptic membrane organization (GO:0001941)3.71743076
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.66508892
45myofibril assembly (GO:0030239)3.64204738
46paraxial mesoderm development (GO:0048339)3.63379505
47pyrimidine nucleobase catabolic process (GO:0006208)3.62082989
48regulation of protein heterodimerization activity (GO:0043497)3.54886951
49syncytium formation by plasma membrane fusion (GO:0000768)3.54345337
50striated muscle contraction (GO:0006941)3.52301448
51substrate-independent telencephalic tangential migration (GO:0021826)3.49359368
52substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.49359368
53myoblast fusion (GO:0007520)3.42647352
54DNA unwinding involved in DNA replication (GO:0006268)3.42277609
55nuclear pore organization (GO:0006999)3.39998905
56transmission of nerve impulse (GO:0019226)3.39508200
57prostate gland epithelium morphogenesis (GO:0060740)3.34433714
58lens fiber cell development (GO:0070307)3.33999519
59G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30308251
60negative regulation of potassium ion transmembrane transport (GO:1901380)3.29023438
61negative regulation of histone methylation (GO:0031061)3.28013287
62positive regulation of myotube differentiation (GO:0010831)3.26512356
63myotube differentiation (GO:0014902)3.24244102
64behavioral response to nicotine (GO:0035095)3.20646943
65syncytium formation (GO:0006949)3.19995003
66glucocorticoid receptor signaling pathway (GO:0042921)3.19944695
67positive regulation of skeletal muscle tissue development (GO:0048643)3.19677414
68skeletal muscle fiber development (GO:0048741)3.18107678
69branching involved in mammary gland duct morphogenesis (GO:0060444)3.18088681
70specification of organ identity (GO:0010092)3.15975514
71cardiac myofibril assembly (GO:0055003)3.14272724
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.13457065
73translational elongation (GO:0006414)3.12697929
74retinal ganglion cell axon guidance (GO:0031290)3.12166136
75actomyosin structure organization (GO:0031032)3.11601474
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.09475292
77proximal/distal pattern formation (GO:0009954)3.08796134
78ribosomal small subunit assembly (GO:0000028)3.07603663
79negative regulation of RNA splicing (GO:0033119)3.07316306
80hippo signaling (GO:0035329)3.05251940
81peptidyl-arginine omega-N-methylation (GO:0035247)3.03803829
82peptidyl-arginine N-methylation (GO:0035246)3.00759817
83peptidyl-arginine methylation (GO:0018216)3.00759817
84regulation of RNA export from nucleus (GO:0046831)3.00414764
85positive regulation of myoblast differentiation (GO:0045663)2.99980428
86regulation of histone H3-K9 methylation (GO:0051570)2.98415330
87negative regulation of DNA repair (GO:0045738)2.98219303
88muscle fiber development (GO:0048747)2.96803563
89mammary gland alveolus development (GO:0060749)2.96678125
90negative regulation of catenin import into nucleus (GO:0035414)2.96221502
91embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95940781
92cellular response to estrogen stimulus (GO:0071391)2.92578281
93* dorsal/ventral pattern formation (GO:0009953)2.90622761
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.90408557
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90003382
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89937638
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89736167
98regulation of morphogenesis of a branching structure (GO:0060688)2.87387002
99protein localization to synapse (GO:0035418)2.86761427
100mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.85965942
101* spinal cord association neuron differentiation (GO:0021527)2.85590999
102cellular protein complex disassembly (GO:0043624)2.85209234
103cotranslational protein targeting to membrane (GO:0006613)2.84692362
104skeletal muscle cell differentiation (GO:0035914)2.84520471
105intraciliary transport (GO:0042073)2.82853545
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82568753
107regulation of organ formation (GO:0003156)2.82200434
108positive regulation of RNA splicing (GO:0033120)2.81235649
109tongue development (GO:0043586)2.81180541
110viral life cycle (GO:0019058)2.80994469
111embryonic body morphogenesis (GO:0010172)2.80572690
112muscle structure development (GO:0061061)2.80281303
113establishment of spindle orientation (GO:0051294)2.79596945
114body morphogenesis (GO:0010171)2.79046173
115RNA stabilization (GO:0043489)2.78228280
116mRNA stabilization (GO:0048255)2.78228280
117protein targeting to ER (GO:0045047)2.78211397
118cytoplasmic mRNA processing body assembly (GO:0033962)2.77883010
119muscle organ development (GO:0007517)2.76747538
120middle ear morphogenesis (GO:0042474)2.75972907
121regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75761738
122negative regulation of cell size (GO:0045792)2.75024368
123mitotic nuclear envelope disassembly (GO:0007077)2.72350548
124peristalsis (GO:0030432)2.72321329
125nonmotile primary cilium assembly (GO:0035058)2.72211751
126regulation of neuroblast proliferation (GO:1902692)2.72047994
127nucleobase catabolic process (GO:0046113)2.71717209
128axon extension (GO:0048675)2.71581013
129negative regulation of mRNA processing (GO:0050686)2.70418826
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69966650
131protein complex disassembly (GO:0043241)2.68933486
132protein localization to kinetochore (GO:0034501)2.68432205
133skeletal muscle tissue development (GO:0007519)2.67905161
134NLS-bearing protein import into nucleus (GO:0006607)2.67538351
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66222356
136mitotic nuclear envelope reassembly (GO:0007084)2.64904799
137nuclear envelope reassembly (GO:0031468)2.64904799
138corticosteroid receptor signaling pathway (GO:0031958)2.64307480
139epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.64213623
140alternative mRNA splicing, via spliceosome (GO:0000380)2.64088475
141neuron recognition (GO:0008038)2.63953416
142cochlea morphogenesis (GO:0090103)2.63165335
143outer ear morphogenesis (GO:0042473)2.61337613
144pre-miRNA processing (GO:0031054)2.61078729
145nuclear envelope disassembly (GO:0051081)2.59477413
146membrane disassembly (GO:0030397)2.59477413
147dentate gyrus development (GO:0021542)2.58711800
148muscle contraction (GO:0006936)2.58360553
149regulation of cell aging (GO:0090342)2.57932065
150maturation of SSU-rRNA (GO:0030490)2.57852774
151sister chromatid segregation (GO:0000819)2.55925371
152peptidyl-lysine dimethylation (GO:0018027)2.55852885
153protein localization to endoplasmic reticulum (GO:0070972)2.55757287
154establishment of mitotic spindle orientation (GO:0000132)2.55296487
155response to muscle activity (GO:0014850)2.54858337
156muscle cell cellular homeostasis (GO:0046716)2.54793875
157negative regulation of systemic arterial blood pressure (GO:0003085)2.54738313
158myotube cell development (GO:0014904)2.54577424
159positive regulation of histone deacetylation (GO:0031065)2.53213689
160pore complex assembly (GO:0046931)2.52857534
161macromolecular complex disassembly (GO:0032984)2.52434954
162regulation of heart morphogenesis (GO:2000826)2.52365148
163urinary tract smooth muscle contraction (GO:0014848)2.51899527
164peripheral nervous system axon ensheathment (GO:0032292)2.51618533
165myelination in peripheral nervous system (GO:0022011)2.51618533
166regulation of DNA endoreduplication (GO:0032875)2.51428021
167neuronal stem cell maintenance (GO:0097150)2.51411466
168DNA topological change (GO:0006265)2.51355087
169striated muscle atrophy (GO:0014891)2.51239991
170camera-type eye morphogenesis (GO:0048593)2.51062110
171positive regulation of neuroblast proliferation (GO:0002052)2.50272883
172developmental induction (GO:0031128)2.48967692
173plasma membrane repair (GO:0001778)2.47323717
174negative regulation of histone modification (GO:0031057)2.46999595
175viral transcription (GO:0019083)2.46319888
176regulation of mRNA stability (GO:0043488)2.46227488
177negative regulation of fatty acid transport (GO:2000192)2.45907552
178ribosomal small subunit biogenesis (GO:0042274)2.45206244
179protein-DNA complex disassembly (GO:0032986)2.45144963
180nucleosome disassembly (GO:0006337)2.45144963
181head development (GO:0060322)2.45049817
182genitalia development (GO:0048806)2.44810139
183cerebral cortex radially oriented cell migration (GO:0021799)2.43389596
184cell-cell signaling involved in cell fate commitment (GO:0045168)2.43382556
185positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.42559424
186translational termination (GO:0006415)2.42203405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70076268
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.87038045
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.08781526
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.66480411
5MYC_22102868_ChIP-Seq_BL_Human3.62780005
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89730450
7* CBX2_27304074_Chip-Seq_ESCs_Mouse2.89448230
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70907897
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.69484715
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.62793588
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60324029
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.59525013
13* EED_16625203_ChIP-ChIP_MESCs_Mouse2.53566195
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40939012
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.40498769
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.38613717
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37252191
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37252191
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.34517691
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32535537
21* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.31556773
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.27553018
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22580280
24TCF7_22412390_ChIP-Seq_EML_Mouse2.22273125
25KDM2B_26808549_Chip-Seq_DND41_Human2.21573483
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20316706
27AR_21909140_ChIP-Seq_LNCAP_Human2.19460708
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15371899
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13916225
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13471204
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03570693
32* EZH2_22144423_ChIP-Seq_EOC_Human2.01450676
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98967867
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98965228
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.97635773
36VDR_21846776_ChIP-Seq_THP-1_Human1.96604380
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96589091
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96489384
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.96467536
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.95646151
41* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93037506
42IGF1R_20145208_ChIP-Seq_DFB_Human1.90815233
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.89990112
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89968927
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.89450506
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89379517
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.87167015
48* KDM2B_26808549_Chip-Seq_JURKAT_Human1.85124565
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84042689
50* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82239868
51* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81833262
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81351123
53* RNF2_27304074_Chip-Seq_NSC_Mouse1.80366561
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77518131
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77257322
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76090139
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74579690
58CLOCK_20551151_ChIP-Seq_293T_Human1.73829280
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72448505
60* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71970391
61DROSHA_22980978_ChIP-Seq_HELA_Human1.68598848
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64886029
63CTCF_27219007_Chip-Seq_Bcells_Human1.63371091
64FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.61379423
65* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57961571
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.55239474
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48271459
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46808238
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46182372
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43875805
71* KDM2B_26808549_Chip-Seq_K562_Human1.43805082
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.42444272
73UTX_26944678_Chip-Seq_JUKART_Human1.40778885
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40572594
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.40306481
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40306321
77BRD4_25478319_ChIP-Seq_HGPS_Human1.40003594
78CHD1_26751641_Chip-Seq_LNCaP_Human1.39769360
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.37649205
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.37219151
81* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37083769
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33285055
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.30825056
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30265978
85* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29831779
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.29815811
87REST_21632747_ChIP-Seq_MESCs_Mouse1.28537098
88IRF1_19129219_ChIP-ChIP_H3396_Human1.28290779
89FUS_26573619_Chip-Seq_HEK293_Human1.27539961
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27280588
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26989142
92* REST_18959480_ChIP-ChIP_MESCs_Mouse1.25498490
93GBX2_23144817_ChIP-Seq_PC3_Human1.24355448
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23629893
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22842143
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21176313
97TP53_22127205_ChIP-Seq_IMR90_Human1.19848286
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19447182
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19338105
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18894337
101CREB1_26743006_Chip-Seq_LNCaP_Human1.18639637
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18147955
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.16883542
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16525979
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15427361
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15411428
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14823685
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13463672
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13456617
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13456617
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13456617
112* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10670681
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10265821
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09845927
115* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08275421
116CIITA_25753668_ChIP-Seq_RAJI_Human1.08103163
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07171792
118RACK7_27058665_Chip-Seq_MCF-7_Human1.06626761
119SCL_19346495_ChIP-Seq_HPC-7_Human1.06599851
120ZNF263_19887448_ChIP-Seq_K562_Human1.06292935
121TP53_16413492_ChIP-PET_HCT116_Human1.06024084
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03863752
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03652216
124* EZH2_27304074_Chip-Seq_ESCs_Mouse1.03583762
125XRN2_22483619_ChIP-Seq_HELA_Human1.01845067
126ATF3_27146783_Chip-Seq_COLON_Human1.01598905
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00882478
128PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00464657
129* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99759314
130* AR_19668381_ChIP-Seq_PC3_Human0.99433546
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99116515
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98869091
133CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98702054
134* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96971200
135E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96275922
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96194648
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.96147110
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94943267
139* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94889895
140* SOX9_26525672_Chip-Seq_HEART_Mouse0.93114956
141* RING1B_27294783_Chip-Seq_ESCs_Mouse0.93071113
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92639617
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92393840
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92221192
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91659595
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91449483
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91005463
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90698624
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90360301
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90208453
151SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90028969
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89134376
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89134376
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88592427
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88592427
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87877721
157RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87582868
158ZNF274_21170338_ChIP-Seq_K562_Hela0.87204381
159SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87079072
160TAF15_26573619_Chip-Seq_HEK293_Human0.86347108
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85672367
162FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85246489
163MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85058898
164ESR2_21235772_ChIP-Seq_MCF-7_Human0.83392663
165* TP53_20018659_ChIP-ChIP_R1E_Mouse0.83378467
166SOX3_22085726_ChIP-Seq_NPCs_Mouse0.82825789
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82794280
168SMAD3_21741376_ChIP-Seq_ESCs_Human0.82460826
169P300_19829295_ChIP-Seq_ESCs_Human0.82296643
170TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81897556
171MAF_26560356_Chip-Seq_TH1_Human0.81806511
172LXR_22292898_ChIP-Seq_THP-1_Human0.80940338
173* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.80871758
174DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80283033
175* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80267489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo8.32060550
2MP0008995_early_reproductive_senescence3.81257914
3MP0000733_abnormal_muscle_development3.79937934
4MP0006292_abnormal_olfactory_placode3.43301308
5MP0010030_abnormal_orbit_morphology3.30592260
6MP0003646_muscle_fatigue2.98183495
7MP0005394_taste/olfaction_phenotype2.88471917
8MP0005499_abnormal_olfactory_system2.88471917
9MP0010307_abnormal_tumor_latency2.71711988
10MP0002653_abnormal_ependyma_morphology2.58893429
11* MP0000750_abnormal_muscle_regeneration2.56463109
12MP0001542_abnormal_bone_strength2.53172523
13MP0004233_abnormal_muscle_weight2.47793522
14MP0002108_abnormal_muscle_morphology2.46726127
15MP0002234_abnormal_pharynx_morphology2.41310978
16MP0003705_abnormal_hypodermis_morpholog2.40095899
17MP0004145_abnormal_muscle_electrophysio2.27257984
18MP0003878_abnormal_ear_physiology2.22416659
19MP0005377_hearing/vestibular/ear_phenot2.22416659
20MP0000751_myopathy2.14753879
21MP0005646_abnormal_pituitary_gland2.13995079
22MP0000566_synostosis2.06489495
23MP0002938_white_spotting1.99561865
24MP0005623_abnormal_meninges_morphology1.99123807
25MP0008438_abnormal_cutaneous_collagen1.92111159
26MP0002736_abnormal_nociception_after1.88255621
27MP0000749_muscle_degeneration1.87874377
28MP0009379_abnormal_foot_pigmentation1.76305226
29MP0003786_premature_aging1.76283355
30MP0005076_abnormal_cell_differentiation1.72411859
31MP0003385_abnormal_body_wall1.68786176
32MP0002102_abnormal_ear_morphology1.67052421
33MP0001727_abnormal_embryo_implantation1.66862371
34MP0005171_absent_coat_pigmentation1.63739141
35MP0009672_abnormal_birth_weight1.60476353
36MP0009250_abnormal_appendicular_skeleto1.58517550
37MP0001299_abnormal_eye_distance/1.58417465
38MP0004142_abnormal_muscle_tone1.54743597
39* MP0000759_abnormal_skeletal_muscle1.53487261
40MP0000778_abnormal_nervous_system1.50736799
41MP0002932_abnormal_joint_morphology1.49838044
42MP0003880_abnormal_central_pattern1.48056659
43MP0005423_abnormal_somatic_nervous1.47062220
44MP0006276_abnormal_autonomic_nervous1.45939584
45MP0005248_abnormal_Harderian_gland1.40285273
46MP0005620_abnormal_muscle_contractility1.37800225
47MP0010352_gastrointestinal_tract_polyps1.37789488
48MP0004133_heterotaxia1.36095849
49MP0004197_abnormal_fetal_growth/weight/1.34351304
50MP0002837_dystrophic_cardiac_calcinosis1.34255077
51MP0002896_abnormal_bone_mineralization1.34116533
52MP0004883_abnormal_blood_vessel1.33845344
53* MP0000747_muscle_weakness1.33214636
54MP0001486_abnormal_startle_reflex1.32674134
55MP0003942_abnormal_urinary_system1.31587368
56MP0003938_abnormal_ear_development1.31091335
57MP0009053_abnormal_anal_canal1.29957313
58* MP0004087_abnormal_muscle_fiber1.29600726
59* MP0005369_muscle_phenotype1.28609924
60MP0003123_paternal_imprinting1.28320773
61MP0003121_genomic_imprinting1.26195905
62MP0003755_abnormal_palate_morphology1.24303702
63MP0000534_abnormal_ureter_morphology1.23891288
64MP0000026_abnormal_inner_ear1.23699923
65MP0000428_abnormal_craniofacial_morphol1.21297353
66MP0002822_catalepsy1.18402018
67MP0002877_abnormal_melanocyte_morpholog1.17737803
68MP0002396_abnormal_hematopoietic_system1.17049782
69* MP0002106_abnormal_muscle_physiology1.16947725
70MP0002160_abnormal_reproductive_system1.16689466
71MP0005503_abnormal_tendon_morphology1.16391523
72MP0000955_abnormal_spinal_cord1.16331405
73MP0003879_abnormal_hair_cell1.16200921
74MP0003787_abnormal_imprinting1.14540269
75MP0002638_abnormal_pupillary_reflex1.13036693
76MP0001286_abnormal_eye_development1.12997541
77MP0004270_analgesia1.12828719
78MP0001849_ear_inflammation1.11609767
79MP0004859_abnormal_synaptic_plasticity1.11540476
80* MP0003935_abnormal_craniofacial_develop1.11115621
81MP0002734_abnormal_mechanical_nocicepti1.08200762
82MP0002114_abnormal_axial_skeleton1.06545111
83MP0003763_abnormal_thymus_physiology1.06421647
84MP0000767_abnormal_smooth_muscle1.05765569
85MP0000049_abnormal_middle_ear1.05722670
86MP0002269_muscular_atrophy1.05298345
87MP0001529_abnormal_vocalization1.03562297
88MP0004130_abnormal_muscle_cell1.03433769
89MP0009703_decreased_birth_body1.02810253
90MP0001485_abnormal_pinna_reflex1.02547807
91MP0000631_abnormal_neuroendocrine_gland1.02326791
92MP0003111_abnormal_nucleus_morphology1.00289936
93MP0010094_abnormal_chromosome_stability1.00270055
94MP0003122_maternal_imprinting0.99784212
95MP0008789_abnormal_olfactory_epithelium0.99524403
96MP0000537_abnormal_urethra_morphology0.98065188
97MP0001968_abnormal_touch/_nociception0.96694497
98MP0002752_abnormal_somatic_nervous0.96618464
99MP0002085_abnormal_embryonic_tissue0.96552952
100MP0003950_abnormal_plasma_membrane0.96018569
101MP0004036_abnormal_muscle_relaxation0.95758850
102MP0003861_abnormal_nervous_system0.94639730
103MP0001730_embryonic_growth_arrest0.94560338
104MP0003091_abnormal_cell_migration0.93559522
105MP0001963_abnormal_hearing_physiology0.92285303
106MP0001984_abnormal_olfaction0.91896012
107MP0004147_increased_porphyrin_level0.91757885
108MP0002697_abnormal_eye_size0.91488082
109MP0003115_abnormal_respiratory_system0.91260888
110MP0004957_abnormal_blastocyst_morpholog0.90125398
111MP0000579_abnormal_nail_morphology0.89784290
112* MP0000432_abnormal_head_morphology0.89719301
113MP0005647_abnormal_sex_gland0.89178847
114MP0002084_abnormal_developmental_patter0.88687169
115MP0000762_abnormal_tongue_morphology0.88490463
116MP0004808_abnormal_hematopoietic_stem0.88300016
117* MP0002233_abnormal_nose_morphology0.87843648
118MP0002063_abnormal_learning/memory/cond0.86072061
119MP0003077_abnormal_cell_cycle0.85800707
120MP0005645_abnormal_hypothalamus_physiol0.85709107
121MP0005451_abnormal_body_composition0.82664864
122MP0002249_abnormal_larynx_morphology0.82282683
123MP0001915_intracranial_hemorrhage0.81973593
124* MP0002116_abnormal_craniofacial_bone0.80850920
125MP0003635_abnormal_synaptic_transmissio0.78938818
126MP0005391_vision/eye_phenotype0.78791751
127MP0000350_abnormal_cell_proliferation0.78352315
128MP0002109_abnormal_limb_morphology0.78127420
129MP0004858_abnormal_nervous_system0.77517415
130MP0004215_abnormal_myocardial_fiber0.77457159
131MP0002882_abnormal_neuron_morphology0.76983472
132MP0002152_abnormal_brain_morphology0.75691006
133MP0002089_abnormal_postnatal_growth/wei0.74459432
134MP0002557_abnormal_social/conspecific_i0.74222805
135* MP0000163_abnormal_cartilage_morphology0.74139579
136MP0008007_abnormal_cellular_replicative0.73649019
137MP0005275_abnormal_skin_tensile0.73589671
138MP0002972_abnormal_cardiac_muscle0.72187656
139MP0002184_abnormal_innervation0.72059991
140MP0001293_anophthalmia0.71361783
141MP0001340_abnormal_eyelid_morphology0.71147486
142MP0002060_abnormal_skin_morphology0.70834462
143MP0003283_abnormal_digestive_organ0.70543519
144MP0002092_abnormal_eye_morphology0.70444026
145MP0001346_abnormal_lacrimal_gland0.70422499
146MP0003567_abnormal_fetal_cardiomyocyte0.70293181
147MP0004084_abnormal_cardiac_muscle0.70199686
148MP0002081_perinatal_lethality0.69574843
149MP0004484_altered_response_of0.69399917
150MP0001879_abnormal_lymphatic_vessel0.69252277
151MP0002111_abnormal_tail_morphology0.68993192
152MP0003890_abnormal_embryonic-extraembry0.68885545
153MP0000427_abnormal_hair_cycle0.68593489
154MP0002113_abnormal_skeleton_development0.68463391
155MP0003937_abnormal_limbs/digits/tail_de0.68145429
156MP0003566_abnormal_cell_adhesion0.66617676

Predicted human phenotypes

RankGene SetZ-score
1Distal lower limb amyotrophy (HP:0008944)5.41197206
2Ulnar deviation of the wrist (HP:0003049)5.40387371
3Deformed tarsal bones (HP:0008119)5.27692130
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.17507829
5Muscle fiber atrophy (HP:0100295)5.13023860
6Difficulty climbing stairs (HP:0003551)5.05057385
7Type 2 muscle fiber atrophy (HP:0003554)4.90870617
8Muscle fiber inclusion bodies (HP:0100299)4.88366154
9Abnormality of the neuromuscular junction (HP:0003398)4.57106182
10Fatigable weakness (HP:0003473)4.57106182
11Exercise-induced muscle cramps (HP:0003710)4.36286246
12Lower limb amyotrophy (HP:0007210)4.33922371
13Absent phalangeal crease (HP:0006109)4.27021513
14Abnormality of the calcaneus (HP:0008364)4.22698512
15Mildly elevated creatine phosphokinase (HP:0008180)3.94463399
16Increased connective tissue (HP:0009025)3.85825872
17Muscle fiber splitting (HP:0003555)3.82510737
18Abnormality of the calf musculature (HP:0001430)3.81367588
19Popliteal pterygium (HP:0009756)3.76464850
20Malignant hyperthermia (HP:0002047)3.61681198
21Abnormal finger flexion creases (HP:0006143)3.52275771
22Difficulty running (HP:0009046)3.52212433
23Weak cry (HP:0001612)3.46548514
24Type 1 muscle fiber predominance (HP:0003803)3.43504576
25Exercise-induced myalgia (HP:0003738)3.42036886
26Pelvic girdle muscle weakness (HP:0003749)3.39191216
27Shoulder girdle muscle weakness (HP:0003547)3.31169420
28Fetal akinesia sequence (HP:0001989)3.23468615
29Gowers sign (HP:0003391)3.11333626
30Amniotic constriction ring (HP:0009775)3.10807368
31Abnormality of placental membranes (HP:0011409)3.10807368
32Premature rupture of membranes (HP:0001788)3.09435019
33Abnormality of the hip-girdle musculature (HP:0001445)3.09376358
34Abnormality of the musculature of the pelvis (HP:0001469)3.09376358
35Increased density of long bones (HP:0006392)2.99877795
36Urethral obstruction (HP:0000796)2.98998820
37Easy fatigability (HP:0003388)2.98494432
38Nemaline bodies (HP:0003798)2.95310697
39Short 4th metacarpal (HP:0010044)2.89329486
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89329486
41Symphalangism affecting the phalanges of the hand (HP:0009773)2.77583731
42Thin ribs (HP:0000883)2.75686876
43Spinal rigidity (HP:0003306)2.72620118
44Limb-girdle muscle weakness (HP:0003325)2.72362715
45Ankle contracture (HP:0006466)2.62959067
46Metatarsus adductus (HP:0001840)2.60062598
47Protrusio acetabuli (HP:0003179)2.57702482
48Abnormality of the pubic bones (HP:0003172)2.53574140
49Rocker bottom foot (HP:0001838)2.52646768
50Shallow orbits (HP:0000586)2.49136860
51Akinesia (HP:0002304)2.47685735
52Aplasia of the musculature (HP:0100854)2.47212321
53Abnormality of the 4th metacarpal (HP:0010012)2.43056529
54Scapular winging (HP:0003691)2.40539167
55Pterygium (HP:0001059)2.38491409
56Myotonia (HP:0002486)2.38383219
57Calf muscle hypertrophy (HP:0008981)2.37242140
58Limb-girdle muscle atrophy (HP:0003797)2.37096525
59Distal upper limb amyotrophy (HP:0007149)2.35340565
60Upper limb amyotrophy (HP:0009129)2.35340565
61EMG: myopathic abnormalities (HP:0003458)2.32042770
62Achilles tendon contracture (HP:0001771)2.27766057
63Short palpebral fissure (HP:0012745)2.25930391
64Cutaneous syndactyly (HP:0012725)2.25318667
65Chin dimple (HP:0010751)2.18094601
66Asymmetry of the thorax (HP:0001555)2.16835090
67Muscle hypertrophy of the lower extremities (HP:0008968)2.15850646
68Hyperacusis (HP:0010780)2.15684160
69Rib fusion (HP:0000902)2.13667751
70Spinal cord lesions (HP:0100561)2.13635604
71Syringomyelia (HP:0003396)2.13635604
72High anterior hairline (HP:0009890)2.12429905
73Myoglobinuria (HP:0002913)2.08442917
74Pseudobulbar signs (HP:0002200)2.05010555
75Long clavicles (HP:0000890)2.02635086
76Abnormality of the Achilles tendon (HP:0005109)2.02613281
77Round ear (HP:0100830)2.02602760
78Tarsal synostosis (HP:0008368)2.01032861
79Colon cancer (HP:0003003)2.00552849
80Oligodactyly (HP:0012165)1.99573509
81Slender build (HP:0001533)1.98169322
82Limited hip movement (HP:0008800)1.97863331
83Hypoplastic pelvis (HP:0008839)1.94861711
84Decreased muscle mass (HP:0003199)1.94714219
85Nonprogressive disorder (HP:0003680)1.92546854
86Abnormality of the shoulder girdle musculature (HP:0001435)1.91640736
87Distal arthrogryposis (HP:0005684)1.90545117
88Abnormality of the phalanges of the hallux (HP:0010057)1.89863987
89Synostosis involving bones of the feet (HP:0009140)1.89857702
90Synostosis involving bones of the lower limbs (HP:0009138)1.89857702
91Webbed neck (HP:0000465)1.87767839
92Cystic hygroma (HP:0000476)1.87304955
93Trismus (HP:0000211)1.86691239
94Hyporeflexia of lower limbs (HP:0002600)1.85539966
95Hypoplastic ischia (HP:0003175)1.85372222
96Postaxial foot polydactyly (HP:0001830)1.85263482
97Breech presentation (HP:0001623)1.84396542
98Nasal speech (HP:0001611)1.83815472
99Generalized muscle weakness (HP:0003324)1.82964803
100Subacute progressive viral hepatitis (HP:0006572)1.81654588
101Ulnar deviation of finger (HP:0009465)1.80887097
102Rimmed vacuoles (HP:0003805)1.79876846
103Reticulocytopenia (HP:0001896)1.79036310
104Rhabdomyolysis (HP:0003201)1.78876255
105Sex reversal (HP:0012245)1.78777063
106Abnormal sex determination (HP:0012244)1.78777063
107Renal duplication (HP:0000075)1.78722143
108Cutaneous finger syndactyly (HP:0010554)1.77003044
109Thin bony cortex (HP:0002753)1.75560757
110Occipital encephalocele (HP:0002085)1.75489958
111Venous abnormality (HP:0002624)1.74747962
112Dislocated radial head (HP:0003083)1.74681861
113Abnormality of the ischium (HP:0003174)1.73706485
114Respiratory insufficiency due to muscle weakness (HP:0002747)1.73342855
115Proximal amyotrophy (HP:0007126)1.72688692
116Bulbar palsy (HP:0001283)1.72309830
117Renovascular hypertension (HP:0100817)1.70881816
118Gait imbalance (HP:0002141)1.70084007
119Broad distal phalanx of finger (HP:0009836)1.69031619
120Septo-optic dysplasia (HP:0100842)1.68741747
121Dilatation of the ascending aorta (HP:0005111)1.67879828
122Abnormality of the aortic arch (HP:0012303)1.67545875
123Rectal prolapse (HP:0002035)1.67473338
124Abnormality of the radial head (HP:0003995)1.67394279
125Increased variability in muscle fiber diameter (HP:0003557)1.66857685
126Renal dysplasia (HP:0000110)1.66786836
127Enlarged penis (HP:0000040)1.66389134
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.66358806
129Nephronophthisis (HP:0000090)1.66325173
130Abnormality of midbrain morphology (HP:0002418)1.65918692
131Molar tooth sign on MRI (HP:0002419)1.65918692
132Depressed nasal ridge (HP:0000457)1.65743059
133Broad metatarsal (HP:0001783)1.65153329
134Myopathic facies (HP:0002058)1.64209712
135Deviation of the hallux (HP:0010051)1.64057059
136Depressed nasal tip (HP:0000437)1.63834232
137Waddling gait (HP:0002515)1.63650703
138Wrist flexion contracture (HP:0001239)1.63626304
139Neonatal respiratory distress (HP:0002643)1.61031159
140Increased nuchal translucency (HP:0010880)1.60891552
141Congenital diaphragmatic hernia (HP:0000776)1.60237513
142Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.58754096
143Abnormality of skeletal muscle fiber size (HP:0012084)1.58692246
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.58573062
145Osteolytic defects of the hand bones (HP:0009699)1.58573062
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.58111295
147Short thorax (HP:0010306)1.58097476
148Hip contracture (HP:0003273)1.56799614
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56593240
150Calcaneovalgus deformity (HP:0001848)1.56410859
151Muscular dystrophy (HP:0003560)1.56156604
152Adducted thumb (HP:0001181)1.56087200
153Advanced eruption of teeth (HP:0006288)1.56061445
154Pancreatic fibrosis (HP:0100732)1.55808784
155Short nail (HP:0001799)1.55082493
156Bladder diverticulum (HP:0000015)1.54653659
157Long eyelashes (HP:0000527)1.54316494
158Macroorchidism (HP:0000053)1.54300374
159Generalized amyotrophy (HP:0003700)1.54183217
160Hallux valgus (HP:0001822)1.53608417
161Trigonocephaly (HP:0000243)1.52725121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.66807013
2MAP4K24.44320496
3CDK194.26485585
4FGFR43.76021895
5TRIB33.22773772
6EPHA43.07520524
7NME13.06670516
8MAP3K103.02838565
9IKBKE2.80441602
10NEK12.78686624
11EEF2K2.57002844
12MOS2.51716703
13MARK12.49098015
14RPS6KA22.27259539
15CDK122.21530906
16PHKG12.14469681
17PHKG22.14469681
18DYRK1B2.06762644
19CDK72.05490279
20MKNK12.03608418
21MKNK22.02913943
22CDK151.99146364
23CDC71.97302422
24AKT21.93587006
25CDK181.90734104
26CDK11A1.87771342
27OBSCN1.83772605
28SIK11.78080978
29BMX1.75701633
30CDK141.71601876
31LATS11.68060193
32NTRK21.65240712
33DYRK21.64563508
34TTN1.62726974
35RPS6KL11.60029616
36RPS6KC11.60029616
37CHUK1.57021814
38EPHB11.56854176
39TYRO31.54458812
40MAPK151.50023006
41PIK3CG1.49821890
42PKN21.44365042
43CDK61.41457402
44RPS6KA61.40785973
45ERN11.40566322
46LIMK11.34313349
47ALK1.30260641
48MTOR1.28564038
49TNIK1.28538550
50MAP3K41.25945206
51ICK1.19308536
52BCKDK1.17872420
53RPS6KB11.17067330
54EPHA31.16757397
55PINK11.15006437
56CAMK41.12383489
57CAMK11.11590588
58WNK31.11580452
59PAK41.10546128
60DYRK1A1.04944337
61FGFR31.04479757
62BRD41.02641832
63ILK1.02173430
64PTK61.01435124
65PDGFRA0.99161279
66MAPKAPK20.99044387
67DYRK30.97970513
68PAK10.97130761
69ERBB30.96978626
70MAPK40.94524653
71SIK20.90182866
72PAK20.89412345
73RIPK10.88929043
74AURKA0.88710209
75MAP2K70.88242692
76LRRK20.84926144
77MAP3K70.81896039
78HIPK20.81603211
79MAPK130.79104069
80PRKD30.78148275
81PRKCG0.77813506
82DDR20.75995559
83BMPR1B0.75851137
84NLK0.71944546
85TSSK60.71816604
86PIK3CA0.69632208
87CDK40.68122744
88RPS6KA10.66847541
89TGFBR10.66455650
90LATS20.63378959
91MARK20.63260001
92PKN10.62604331
93ERBB40.60376116
94PRKAA10.60216479
95FGFR10.60176307
96EPHB20.58211726
97CAMK2A0.57765217
98ABL10.57069353
99MAP2K40.56573154
100DMPK0.55346643
101ROCK20.55201418
102PLK20.53963220
103CCNB10.53508674
104RPS6KB20.53215119
105TAOK10.52246868
106CDK20.51531961
107RPS6KA40.49575644
108PIM20.49213345
109CDK10.48461007
110CDK80.48332387
111CHEK10.48186391
112PASK0.46835337
113CAMK2G0.46467530
114STK110.46424195
115PRKACA0.45635971
116CASK0.45626714
117STK30.45420558
118STK100.45342090
119AKT10.45160714
120SCYL20.44218435
121MAPK140.43687121
122BTK0.43308329
123ATR0.42788592
124MAPK80.42082448
125PLK10.41293914
126UHMK10.41197176
127PDGFRB0.40722863
128CDK90.40677007
129NEK20.40382455
130FGFR20.39234611
131ROCK10.39020030
132CAMK1G0.38398202
133AURKB0.36750603
134CDK50.36334937
135MAPK70.36281054
136CAMK1D0.36139619
137PRKCZ0.35765852
138TTK0.35393085
139NUAK10.35324495
140PRKG10.34840856
141TRIM280.33568160
142MAP3K80.32904117
143PRKDC0.32670357
144RPS6KA30.31080119
145MAPK120.30786455
146PAK60.30122982
147DAPK20.30019342
148PRKCH0.29856526
149CHEK20.29720877
150MAPK10.29055553
151PRKACB0.29053592
152OXSR10.28748058
153TAF10.27748240
154PIM10.27017761
155ATM0.27011173
156GRK10.26913299
157PRKAA20.25073663
158SGK2230.25035479

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042602.98961247
2Proteoglycans in cancer_Homo sapiens_hsa052052.32653866
3Chronic myeloid leukemia_Homo sapiens_hsa052202.10945916
4MicroRNAs in cancer_Homo sapiens_hsa052062.09013673
5Spliceosome_Homo sapiens_hsa030402.06692356
6Viral myocarditis_Homo sapiens_hsa054162.01254104
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00600639
8Basal cell carcinoma_Homo sapiens_hsa052171.99264580
9mRNA surveillance pathway_Homo sapiens_hsa030151.95492061
10Dorso-ventral axis formation_Homo sapiens_hsa043201.85785584
11Thyroid hormone signaling pathway_Homo sapiens_hsa049191.85209739
12Cell cycle_Homo sapiens_hsa041101.83472211
13Notch signaling pathway_Homo sapiens_hsa043301.83418530
14Pentose phosphate pathway_Homo sapiens_hsa000301.80309301
15Hippo signaling pathway_Homo sapiens_hsa043901.77291342
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74240510
17Dilated cardiomyopathy_Homo sapiens_hsa054141.71993546
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71167476
19One carbon pool by folate_Homo sapiens_hsa006701.69010412
20DNA replication_Homo sapiens_hsa030301.67348660
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66063556
22Adherens junction_Homo sapiens_hsa045201.65849474
23Focal adhesion_Homo sapiens_hsa045101.60222269
24RNA transport_Homo sapiens_hsa030131.59669510
25Estrogen signaling pathway_Homo sapiens_hsa049151.57612683
26TGF-beta signaling pathway_Homo sapiens_hsa043501.56197126
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55562930
28Biosynthesis of amino acids_Homo sapiens_hsa012301.50830674
29HTLV-I infection_Homo sapiens_hsa051661.49891575
30Colorectal cancer_Homo sapiens_hsa052101.49250006
31Butanoate metabolism_Homo sapiens_hsa006501.44946853
32Glioma_Homo sapiens_hsa052141.43291213
33Prolactin signaling pathway_Homo sapiens_hsa049171.43080075
34Non-small cell lung cancer_Homo sapiens_hsa052231.41342331
35Endometrial cancer_Homo sapiens_hsa052131.36066505
36Protein digestion and absorption_Homo sapiens_hsa049741.35981104
37Mismatch repair_Homo sapiens_hsa034301.34383793
38Hedgehog signaling pathway_Homo sapiens_hsa043401.32567258
39Wnt signaling pathway_Homo sapiens_hsa043101.31946122
40Calcium signaling pathway_Homo sapiens_hsa040201.31207117
41ECM-receptor interaction_Homo sapiens_hsa045121.29597860
42Prostate cancer_Homo sapiens_hsa052151.28755762
43Circadian entrainment_Homo sapiens_hsa047131.28224520
44Salivary secretion_Homo sapiens_hsa049701.28120659
45Base excision repair_Homo sapiens_hsa034101.27971669
46Pancreatic cancer_Homo sapiens_hsa052121.27884383
47Oxytocin signaling pathway_Homo sapiens_hsa049211.27463638
48Small cell lung cancer_Homo sapiens_hsa052221.27253150
49Lysine degradation_Homo sapiens_hsa003101.24262726
50Acute myeloid leukemia_Homo sapiens_hsa052211.23871250
51Phototransduction_Homo sapiens_hsa047441.23585355
52Ribosome_Homo sapiens_hsa030101.17731787
53Carbon metabolism_Homo sapiens_hsa012001.16977021
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13881139
55Axon guidance_Homo sapiens_hsa043601.13443600
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.13392868
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11979303
58mTOR signaling pathway_Homo sapiens_hsa041501.09000734
59Morphine addiction_Homo sapiens_hsa050321.08271984
60Propanoate metabolism_Homo sapiens_hsa006401.08012495
61GABAergic synapse_Homo sapiens_hsa047271.07702897
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05735069
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05678873
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05444803
65* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03099237
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02685978
67Glutamatergic synapse_Homo sapiens_hsa047241.02059171
68Sulfur relay system_Homo sapiens_hsa041221.01180740
69Insulin secretion_Homo sapiens_hsa049111.00894422
70Bladder cancer_Homo sapiens_hsa052190.99665915
71Pathways in cancer_Homo sapiens_hsa052000.99157731
72Parkinsons disease_Homo sapiens_hsa050120.99138876
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98999565
74Arginine and proline metabolism_Homo sapiens_hsa003300.96633146
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96564226
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95240346
77MAPK signaling pathway_Homo sapiens_hsa040100.94791861
78Viral carcinogenesis_Homo sapiens_hsa052030.94779288
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94222548
80Tight junction_Homo sapiens_hsa045300.93693442
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93494187
82B cell receptor signaling pathway_Homo sapiens_hsa046620.93252366
83Nicotine addiction_Homo sapiens_hsa050330.91658359
84Olfactory transduction_Homo sapiens_hsa047400.91441516
85Homologous recombination_Homo sapiens_hsa034400.91382315
86ErbB signaling pathway_Homo sapiens_hsa040120.90943186
87p53 signaling pathway_Homo sapiens_hsa041150.89863502
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88737128
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.88657166
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.87973917
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87695604
92Cholinergic synapse_Homo sapiens_hsa047250.85022248
93Hepatitis B_Homo sapiens_hsa051610.84474996
94Fructose and mannose metabolism_Homo sapiens_hsa000510.84092957
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82810414
96Renal cell carcinoma_Homo sapiens_hsa052110.82636864
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81354057
98FoxO signaling pathway_Homo sapiens_hsa040680.81032954
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80931518
100Melanogenesis_Homo sapiens_hsa049160.80620063
101Fanconi anemia pathway_Homo sapiens_hsa034600.80149123
102Melanoma_Homo sapiens_hsa052180.80047712
103Alcoholism_Homo sapiens_hsa050340.78560829
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77836529
105Platelet activation_Homo sapiens_hsa046110.77799194
106Oxidative phosphorylation_Homo sapiens_hsa001900.77291510
107Steroid biosynthesis_Homo sapiens_hsa001000.76937906
108Huntingtons disease_Homo sapiens_hsa050160.76862856
109Salmonella infection_Homo sapiens_hsa051320.75800970
110Nucleotide excision repair_Homo sapiens_hsa034200.75656204
111Gastric acid secretion_Homo sapiens_hsa049710.75401950
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.75370911
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75207593
114Selenocompound metabolism_Homo sapiens_hsa004500.74821236
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.74476865
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74467440
117Oocyte meiosis_Homo sapiens_hsa041140.73562891
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73227003
119Alzheimers disease_Homo sapiens_hsa050100.73214261
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73064870
121Thyroid cancer_Homo sapiens_hsa052160.72876264
122Dopaminergic synapse_Homo sapiens_hsa047280.71931723
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70699097
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70658697
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.69946773
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69118613
127Fatty acid degradation_Homo sapiens_hsa000710.69109497
128AMPK signaling pathway_Homo sapiens_hsa041520.68522344
129Starch and sucrose metabolism_Homo sapiens_hsa005000.68435562
130Insulin signaling pathway_Homo sapiens_hsa049100.67118810
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67108098
132Epstein-Barr virus infection_Homo sapiens_hsa051690.65872899
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65687962
134Taste transduction_Homo sapiens_hsa047420.65545636
135Rap1 signaling pathway_Homo sapiens_hsa040150.65259598
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64903739
137Basal transcription factors_Homo sapiens_hsa030220.64768578
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64206555
139Circadian rhythm_Homo sapiens_hsa047100.61044710
140Linoleic acid metabolism_Homo sapiens_hsa005910.60696617
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60480295
142Insulin resistance_Homo sapiens_hsa049310.60372465
143Ovarian steroidogenesis_Homo sapiens_hsa049130.59203859
144Gap junction_Homo sapiens_hsa045400.58479126
145RNA degradation_Homo sapiens_hsa030180.58455727
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58319988
147Nitrogen metabolism_Homo sapiens_hsa009100.57588920
148VEGF signaling pathway_Homo sapiens_hsa043700.54780228
149beta-Alanine metabolism_Homo sapiens_hsa004100.54617228
150Amoebiasis_Homo sapiens_hsa051460.54290876
151Glucagon signaling pathway_Homo sapiens_hsa049220.54202941
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52254893
153Amphetamine addiction_Homo sapiens_hsa050310.51062891
154HIF-1 signaling pathway_Homo sapiens_hsa040660.51034093
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50396438
156cAMP signaling pathway_Homo sapiens_hsa040240.50120882
157Tryptophan metabolism_Homo sapiens_hsa003800.49314560
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48822296
159Apoptosis_Homo sapiens_hsa042100.47946011
160Long-term depression_Homo sapiens_hsa047300.47527458
161Shigellosis_Homo sapiens_hsa051310.45762959
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.45642369
163Galactose metabolism_Homo sapiens_hsa000520.45488115
164Pyruvate metabolism_Homo sapiens_hsa006200.43327623
165Cocaine addiction_Homo sapiens_hsa050300.42306735
166Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42040120
167Protein export_Homo sapiens_hsa030600.41657814
168Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41578452
169Thyroid hormone synthesis_Homo sapiens_hsa049180.40380479

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »