PAXBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.40117059
2DNA unwinding involved in DNA replication (GO:0006268)4.41815680
3mitotic sister chromatid cohesion (GO:0007064)4.29223592
4sister chromatid segregation (GO:0000819)4.28949568
5regulation of DNA endoreduplication (GO:0032875)3.99236044
6peptidyl-lysine trimethylation (GO:0018023)3.93503132
7meiotic chromosome segregation (GO:0045132)3.81436643
8nuclear pore complex assembly (GO:0051292)3.73037533
9resolution of meiotic recombination intermediates (GO:0000712)3.71246854
10histone H3-K4 methylation (GO:0051568)3.70335754
11synapsis (GO:0007129)3.67250615
12DNA double-strand break processing (GO:0000729)3.65206814
13mitotic sister chromatid segregation (GO:0000070)3.61557724
14mitotic chromosome condensation (GO:0007076)3.56995003
15kinetochore organization (GO:0051383)3.55589909
16mRNA splice site selection (GO:0006376)3.54983836
17regulation of histone H3-K9 methylation (GO:0051570)3.51886209
18V(D)J recombination (GO:0033151)3.49260715
19DNA synthesis involved in DNA repair (GO:0000731)3.48943738
20centriole replication (GO:0007099)3.39909787
21regulation of centrosome duplication (GO:0010824)3.36435213
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33363567
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.33363567
24regulation of translation, ncRNA-mediated (GO:0045974)3.33363567
25DNA duplex unwinding (GO:0032508)3.29714880
26negative regulation of histone methylation (GO:0031061)3.28620867
27DNA replication initiation (GO:0006270)3.28507327
28DNA geometric change (GO:0032392)3.26969356
29regulation of centrosome cycle (GO:0046605)3.25384014
30non-recombinational repair (GO:0000726)3.25071936
31double-strand break repair via nonhomologous end joining (GO:0006303)3.25071936
32microtubule depolymerization (GO:0007019)3.21308826
33DNA replication checkpoint (GO:0000076)3.20469109
34metaphase plate congression (GO:0051310)3.19976527
35mitotic nuclear envelope disassembly (GO:0007077)3.19808883
36protein localization to kinetochore (GO:0034501)3.15747043
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.13548233
38regulation of DNA damage checkpoint (GO:2000001)3.13485529
39spindle checkpoint (GO:0031577)3.10980315
40negative thymic T cell selection (GO:0045060)3.10873894
41mitotic spindle checkpoint (GO:0071174)3.09132533
42negative T cell selection (GO:0043383)3.08720288
43regulation of sister chromatid segregation (GO:0033045)3.08108259
44regulation of mitotic sister chromatid separation (GO:0010965)3.08108259
45regulation of mitotic sister chromatid segregation (GO:0033047)3.08108259
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.07875378
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07875378
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07875378
49mitotic metaphase plate congression (GO:0007080)3.06110795
50neural tube formation (GO:0001841)3.05941655
51mitotic recombination (GO:0006312)3.05587223
52negative regulation of chromosome segregation (GO:0051985)3.04954632
53regulation of sister chromatid cohesion (GO:0007063)3.04350299
54membrane disassembly (GO:0030397)3.02419492
55nuclear envelope disassembly (GO:0051081)3.02419492
56DNA conformation change (GO:0071103)3.02168145
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01689454
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01689454
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01304924
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.01304924
61negative regulation of sister chromatid segregation (GO:0033046)3.01304924
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01304924
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01304924
64mitotic spindle assembly checkpoint (GO:0007094)2.97767128
65histone lysine methylation (GO:0034968)2.97525458
66histone H3-K36 demethylation (GO:0070544)2.97313565
67negative regulation of mRNA metabolic process (GO:1903312)2.96132694
68pore complex assembly (GO:0046931)2.94877434
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93773833
70negative regulation of cell killing (GO:0031342)2.93773833
71reciprocal DNA recombination (GO:0035825)2.93643399
72reciprocal meiotic recombination (GO:0007131)2.93643399
73spindle assembly checkpoint (GO:0071173)2.93436875
74chromatin remodeling at centromere (GO:0031055)2.93026060
75nuclear pore organization (GO:0006999)2.92948967
76regulation of chromosome segregation (GO:0051983)2.91382221
77kinetochore assembly (GO:0051382)2.88645325
78* positive regulation of histone methylation (GO:0031062)2.88091879
79negative regulation of DNA-dependent DNA replication (GO:2000104)2.87277944
80centriole assembly (GO:0098534)2.87049977
81negative regulation of B cell proliferation (GO:0030889)2.86718411
82protein localization to chromosome, centromeric region (GO:0071459)2.86124473
83DNA ligation (GO:0006266)2.84489079
84peptidyl-lysine methylation (GO:0018022)2.84019736
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83507997
86microtubule anchoring (GO:0034453)2.83391290
87mRNA export from nucleus (GO:0006406)2.82930765
88RNA export from nucleus (GO:0006405)2.82847566
89T cell selection (GO:0045058)2.82824478
90* regulation of histone methylation (GO:0031060)2.81631574
91positive regulation of gamma-delta T cell activation (GO:0046645)2.81104457
92mRNA transport (GO:0051028)2.80486124
93negative regulation of DNA recombination (GO:0045910)2.78138889
94positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.77082084
95histone H3-K9 methylation (GO:0051567)2.75402224
96cerebellar Purkinje cell differentiation (GO:0021702)2.74492587
97cerebellar granule cell differentiation (GO:0021707)2.67791077
98positive regulation of granulocyte differentiation (GO:0030854)2.66081717
99positive T cell selection (GO:0043368)2.62126985
100cytoplasmic mRNA processing body assembly (GO:0033962)2.57223551
101interkinetic nuclear migration (GO:0022027)2.56558908
102histone H3-K9 modification (GO:0061647)2.56394965
103pre-miRNA processing (GO:0031054)2.55304697
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53485153
105myeloid dendritic cell activation (GO:0001773)2.48744248
106regulation of regulatory T cell differentiation (GO:0045589)2.48525534
107sister chromatid cohesion (GO:0007062)2.47987807
108thymic T cell selection (GO:0045061)2.47653377
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.47113568
110histone methylation (GO:0016571)2.42179801
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40835791
112tolerance induction (GO:0002507)2.37848080
113monoubiquitinated protein deubiquitination (GO:0035520)2.36573992
114regulation of MHC class II biosynthetic process (GO:0045346)2.35902915
115positive thymic T cell selection (GO:0045059)2.35506602
116regulation of histone H3-K27 methylation (GO:0061085)2.34456223
117response to pheromone (GO:0019236)2.34292624
118NIK/NF-kappaB signaling (GO:0038061)2.33216762
119B cell homeostasis (GO:0001782)2.30232477
120alternative mRNA splicing, via spliceosome (GO:0000380)2.29898756
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28070496
122poly(A)+ mRNA export from nucleus (GO:0016973)2.27537514
123regulation of B cell receptor signaling pathway (GO:0050855)2.22934333
124regulation of RNA export from nucleus (GO:0046831)2.22227682
125embryonic hemopoiesis (GO:0035162)2.21731098
126corticosteroid receptor signaling pathway (GO:0031958)2.21542974
127negative regulation of mRNA processing (GO:0050686)2.19183001
128DNA topological change (GO:0006265)2.17765572
129synaptic transmission, glutamatergic (GO:0035249)2.17388467
130histone H2A acetylation (GO:0043968)2.15896562
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.15551910
132pericardium development (GO:0060039)2.15455243
133cellular response to interleukin-15 (GO:0071350)2.15184720
134positive regulation of histone H3-K4 methylation (GO:0051571)2.12453888
135presynaptic membrane assembly (GO:0097105)2.11868922
136glutamate receptor signaling pathway (GO:0007215)2.11857919
137regulation of granulocyte differentiation (GO:0030852)2.11376349
138histone mRNA catabolic process (GO:0071044)2.11353780
139glucocorticoid receptor signaling pathway (GO:0042921)2.11163680
140replication fork processing (GO:0031297)2.11140964
141presynaptic membrane organization (GO:0097090)2.09245943
142DNA strand renaturation (GO:0000733)2.09220077
143regulation of telomere maintenance (GO:0032204)2.09072787
144myeloid dendritic cell differentiation (GO:0043011)2.08728810
145regulation of mRNA splicing, via spliceosome (GO:0048024)2.08470888
146megakaryocyte development (GO:0035855)2.08448024
147regulation of B cell proliferation (GO:0030888)2.08259719
148nucleus localization (GO:0051647)2.06599724
149cell differentiation in hindbrain (GO:0021533)2.06511990
150negative regulation of RNA splicing (GO:0033119)2.05953785
151regulation of fibroblast apoptotic process (GO:2000269)2.04466559
152regulation of chronic inflammatory response (GO:0002676)2.04260914
153locomotory exploration behavior (GO:0035641)2.03669062
154negative regulation of B cell activation (GO:0050869)2.03236838
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.02949463
156phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.02385431
157regulation of nucleobase-containing compound transport (GO:0032239)2.02167089
158CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.01489105
159regulation of T cell tolerance induction (GO:0002664)2.01465550
160response to interleukin-15 (GO:0070672)2.01440747
161T cell homeostasis (GO:0043029)2.00941117
162histone lysine demethylation (GO:0070076)1.99879777
163maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)1.99652443
164microtubule nucleation (GO:0007020)1.99567031
165B cell receptor signaling pathway (GO:0050853)1.99128215
166regulation of centriole replication (GO:0046599)1.99062893
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.98664369
168tyrosine phosphorylation of STAT protein (GO:0007260)1.98596527
169histone demethylation (GO:0016577)1.98283190
170regulation of histone H3-K4 methylation (GO:0051569)1.96668129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62241898
2E2F7_22180533_ChIP-Seq_HELA_Human4.27083696
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06482941
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.82108780
5IGF1R_20145208_ChIP-Seq_DFB_Human2.65090783
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48352224
7GBX2_23144817_ChIP-Seq_PC3_Human2.36519850
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31210386
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27519897
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24697863
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.24165542
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22410899
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.21657487
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.19549679
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12313501
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08721016
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03458429
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01585836
19ZNF274_21170338_ChIP-Seq_K562_Hela2.00772391
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80673206
21RUNX_20019798_ChIP-Seq_JUKART_Human1.80302371
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.78522460
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76631036
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75289825
25ELK1_19687146_ChIP-ChIP_HELA_Human1.74852111
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74748792
27SCL_19346495_ChIP-Seq_HPC-7_Human1.72861464
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72533812
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.71113873
30EZH2_22144423_ChIP-Seq_EOC_Human1.62944546
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62257849
32TP53_16413492_ChIP-PET_HCT116_Human1.61160132
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60776988
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60776988
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59577420
36FUS_26573619_Chip-Seq_HEK293_Human1.52973280
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.50082848
38EWS_26573619_Chip-Seq_HEK293_Human1.49646904
39AR_21572438_ChIP-Seq_LNCaP_Human1.49086536
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45765503
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.44294346
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43554231
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42407598
44VDR_22108803_ChIP-Seq_LS180_Human1.42300643
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.41228097
46AR_21909140_ChIP-Seq_LNCAP_Human1.41114605
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.39542355
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.37328745
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36996734
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36200083
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35874397
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35472377
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35468507
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34674873
55DROSHA_22980978_ChIP-Seq_HELA_Human1.34007024
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33348726
57SMAD4_21799915_ChIP-Seq_A2780_Human1.31837951
58TAF15_26573619_Chip-Seq_HEK293_Human1.31555942
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31202937
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.31042763
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29098457
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28597720
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.28419854
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27643269
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26371131
66IRF1_19129219_ChIP-ChIP_H3396_Human1.25837852
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24700783
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.24432435
69STAT3_23295773_ChIP-Seq_U87_Human1.24159022
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23483819
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23318344
72TCF4_23295773_ChIP-Seq_U87_Human1.23149421
73TCF7_22412390_ChIP-Seq_EML_Mouse1.21961164
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20574708
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20249328
76RNF2_27304074_Chip-Seq_NSC_Mouse1.19870771
77VDR_23849224_ChIP-Seq_CD4+_Human1.19780298
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19594470
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19426274
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18947097
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17140012
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16166810
83CBP_20019798_ChIP-Seq_JUKART_Human1.16166810
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15709011
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14407464
86MYC_18940864_ChIP-ChIP_HL60_Human1.14237433
87P300_19829295_ChIP-Seq_ESCs_Human1.12645971
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12475559
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.11613505
90ER_23166858_ChIP-Seq_MCF-7_Human1.11026616
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.10872357
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10868548
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08653423
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08443168
95MYB_26560356_Chip-Seq_TH2_Human1.07751292
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07154716
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.06607027
98MYC_22102868_ChIP-Seq_BL_Human1.05562610
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04834102
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04344527
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04298145
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03142616
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03058370
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.03047833
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02885471
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.02696467
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.02531703
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.02530782
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.02458500
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01206798
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00738084
112P53_22387025_ChIP-Seq_ESCs_Mouse1.00561783
113MYB_26560356_Chip-Seq_TH1_Human1.00531947
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.00215085
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00057819
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00009588
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.00007885
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99376078
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98647275
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97700796
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.97622363
122FOXP3_21729870_ChIP-Seq_TREG_Human0.97506162
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97243539
124AR_25329375_ChIP-Seq_VCAP_Human0.97043846
125JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96602733
126RUNX2_22187159_ChIP-Seq_PCA_Human0.96126327
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95559886
128CIITA_25753668_ChIP-Seq_RAJI_Human0.95432690
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94600304
130SOX9_26525672_Chip-Seq_HEART_Mouse0.94262051
131AHR_22903824_ChIP-Seq_MCF-7_Human0.93946996
132AR_19668381_ChIP-Seq_PC3_Human0.93206706
133TTF2_22483619_ChIP-Seq_HELA_Human0.92466717
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.92095486
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92071634
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91807124
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91795769
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90531053
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.89412568
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89283777
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89006253
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88792880
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88628344
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88452247
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88322261
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88276875
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88177176
148KDM5A_27292631_Chip-Seq_BREAST_Human0.87640011
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86502161
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.86277791
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85504334
152SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85158750
153FLI1_21867929_ChIP-Seq_TH2_Mouse0.84603702
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83417230
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82883022
156FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82576817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.50091038
2MP0003787_abnormal_imprinting3.81645204
3MP0008057_abnormal_DNA_replication2.48284978
4MP0003693_abnormal_embryo_hatching2.39171772
5MP0002396_abnormal_hematopoietic_system2.29358320
6MP0001835_abnormal_antigen_presentation2.20662008
7MP0004957_abnormal_blastocyst_morpholog2.17165238
8MP0005671_abnormal_response_to2.12362239
9MP0004859_abnormal_synaptic_plasticity2.04290484
10MP0005174_abnormal_tail_pigmentation1.98320407
11MP0008877_abnormal_DNA_methylation1.94001906
12MP0004808_abnormal_hematopoietic_stem1.93864242
13MP0001873_stomach_inflammation1.93091509
14MP0003763_abnormal_thymus_physiology1.93017765
15MP0003121_genomic_imprinting1.92536404
16MP0003937_abnormal_limbs/digits/tail_de1.72118486
17MP0003300_gastrointestinal_ulcer1.71846987
18MP0008932_abnormal_embryonic_tissue1.70270199
19MP0008995_early_reproductive_senescence1.67574197
20MP0002102_abnormal_ear_morphology1.64683155
21MP0003567_abnormal_fetal_cardiomyocyte1.64633382
22MP0002166_altered_tumor_susceptibility1.64003871
23MP0000015_abnormal_ear_pigmentation1.63553468
24MP0002095_abnormal_skin_pigmentation1.61638600
25MP0009278_abnormal_bone_marrow1.58717412
26MP0002009_preneoplasia1.58564999
27MP0005397_hematopoietic_system_phenotyp1.58350323
28MP0001545_abnormal_hematopoietic_system1.58350323
29MP0006292_abnormal_olfactory_placode1.57724638
30MP0004510_myositis1.55969926
31MP0009046_muscle_twitch1.55821275
32MP0003136_yellow_coat_color1.54088458
33MP0001800_abnormal_humoral_immune1.51663726
34MP0000703_abnormal_thymus_morphology1.50965316
35MP0002084_abnormal_developmental_patter1.50632339
36MP0003303_peritoneal_inflammation1.50624434
37MP0001790_abnormal_immune_system1.49862456
38MP0005387_immune_system_phenotype1.49862456
39MP0000383_abnormal_hair_follicle1.38537341
40MP0004197_abnormal_fetal_growth/weight/1.37329053
41MP0001672_abnormal_embryogenesis/_devel1.37049493
42MP0005380_embryogenesis_phenotype1.37049493
43MP0001929_abnormal_gametogenesis1.35005519
44MP0002398_abnormal_bone_marrow1.34308320
45MP0001697_abnormal_embryo_size1.33472318
46MP0002006_tumorigenesis1.32871777
47MP0000427_abnormal_hair_cycle1.30475715
48MP0005076_abnormal_cell_differentiation1.28069133
49MP0002088_abnormal_embryonic_growth/wei1.26758252
50MP0003984_embryonic_growth_retardation1.26669878
51MP0002452_abnormal_antigen_presenting1.26554308
52MP0010094_abnormal_chromosome_stability1.26231898
53MP0000631_abnormal_neuroendocrine_gland1.25517068
54MP0001486_abnormal_startle_reflex1.24556916
55MP0000350_abnormal_cell_proliferation1.24515744
56MP0000566_synostosis1.23482765
57MP0001286_abnormal_eye_development1.22900485
58MP0008007_abnormal_cellular_replicative1.22193695
59MP0002210_abnormal_sex_determination1.21802898
60MP0009745_abnormal_behavioral_response1.20449764
61MP0003635_abnormal_synaptic_transmissio1.19860413
62MP0003943_abnormal_hepatobiliary_system1.19538657
63MP0001819_abnormal_immune_cell1.19155075
64MP0002420_abnormal_adaptive_immunity1.18504941
65MP0002085_abnormal_embryonic_tissue1.17680171
66MP0010678_abnormal_skin_adnexa1.16666265
67MP0005423_abnormal_somatic_nervous1.16543090
68MP0005310_abnormal_salivary_gland1.16484725
69MP0005171_absent_coat_pigmentation1.16413039
70MP0001730_embryonic_growth_arrest1.14709565
71MP0002697_abnormal_eye_size1.14220433
72MP0000685_abnormal_immune_system1.13390890
73MP0002233_abnormal_nose_morphology1.13351255
74MP0005187_abnormal_penis_morphology1.13192435
75MP0003890_abnormal_embryonic-extraembry1.12663906
76MP0003119_abnormal_digestive_system1.11986355
77MP0001293_anophthalmia1.11858445
78MP0000647_abnormal_sebaceous_gland1.11657506
79MP0003698_abnormal_male_reproductive1.11590200
80MP0001145_abnormal_male_reproductive1.10881225
81MP0003866_abnormal_defecation1.09478917
82MP0002751_abnormal_autonomic_nervous1.09433363
83MP0004885_abnormal_endolymph1.08236545
84MP0000716_abnormal_immune_system1.08196889
85MP0002723_abnormal_immune_serum1.06421091
86MP0002277_abnormal_respiratory_mucosa1.05894646
87MP0003786_premature_aging1.05350941
88MP0002067_abnormal_sensory_capabilities1.05106211
89MP0009697_abnormal_copulation1.04987931
90MP0000653_abnormal_sex_gland1.04776520
91MP0006072_abnormal_retinal_apoptosis1.03664070
92MP0000778_abnormal_nervous_system1.01794943
93MP0004742_abnormal_vestibular_system1.01234633
94MP0008569_lethality_at_weaning1.01140254
95MP0009672_abnormal_birth_weight1.00823788
96MP0003385_abnormal_body_wall1.00691631
97MP0003111_abnormal_nucleus_morphology1.00252225
98MP0003123_paternal_imprinting0.99312501
99MP0002160_abnormal_reproductive_system0.97424208
100MP0005646_abnormal_pituitary_gland0.96609179
101MP0002064_seizures0.95973319
102MP0003755_abnormal_palate_morphology0.95934334
103MP0003122_maternal_imprinting0.94232166
104MP0005000_abnormal_immune_tolerance0.93917347
105MP0002080_prenatal_lethality0.93405751
106MP0000371_diluted_coat_color0.92298435
107MP0005394_taste/olfaction_phenotype0.91444352
108MP0005499_abnormal_olfactory_system0.91444352
109MP0008789_abnormal_olfactory_epithelium0.91359520
110MP0002722_abnormal_immune_system0.91307671
111MP0005391_vision/eye_phenotype0.91143564
112MP0000372_irregular_coat_pigmentation0.91055224
113MP0005075_abnormal_melanosome_morpholog0.90760915
114MP0001188_hyperpigmentation0.90541304
115MP0005253_abnormal_eye_physiology0.90339253
116MP0002092_abnormal_eye_morphology0.89695035
117MP0002063_abnormal_learning/memory/cond0.89011891
118MP0002557_abnormal_social/conspecific_i0.88587007
119MP0001529_abnormal_vocalization0.87844369
120MP0005248_abnormal_Harderian_gland0.87195904
121MP0000428_abnormal_craniofacial_morphol0.86618748
122MP0010155_abnormal_intestine_physiology0.86504457
123MP0005409_darkened_coat_color0.86262430
124MP0003718_maternal_effect0.84972950
125MP0008058_abnormal_DNA_repair0.84708464
126MP0000313_abnormal_cell_death0.84382960
127MP0002086_abnormal_extraembryonic_tissu0.83395516
128MP0002938_white_spotting0.83250595
129MP0002429_abnormal_blood_cell0.82778411
130MP0001485_abnormal_pinna_reflex0.81384773
131MP0002572_abnormal_emotion/affect_behav0.81134011
132MP0001119_abnormal_female_reproductive0.80815518
133MP0003077_abnormal_cell_cycle0.80765164
134MP0001984_abnormal_olfaction0.80632980
135MP0002075_abnormal_coat/hair_pigmentati0.80117450
136MP0005220_abnormal_exocrine_pancreas0.79795421
137MP0002148_abnormal_hypersensitivity_rea0.78886114
138MP0004133_heterotaxia0.78471711
139MP0000689_abnormal_spleen_morphology0.78415913
140MP0000733_abnormal_muscle_development0.78313723
141MP0003115_abnormal_respiratory_system0.78210753
142MP0000432_abnormal_head_morphology0.77612095
143MP0002234_abnormal_pharynx_morphology0.77268541
144MP0000516_abnormal_urinary_system0.76842933
145MP0005367_renal/urinary_system_phenotyp0.76842933
146MP0001348_abnormal_lacrimal_gland0.76710556
147MP0003938_abnormal_ear_development0.76422435
148MP0000955_abnormal_spinal_cord0.76362627
149MP0001501_abnormal_sleep_pattern0.76355960
150MP0009703_decreased_birth_body0.74622287
151MP0001915_intracranial_hemorrhage0.71888293
152MP0002163_abnormal_gland_morphology0.71638900
153MP0000490_abnormal_crypts_of0.71118722
154MP0010352_gastrointestinal_tract_polyps0.70965225
155MP0002272_abnormal_nervous_system0.69321892
156MP0002184_abnormal_innervation0.68905420
157MP0002419_abnormal_innate_immunity0.68306036
158MP0001346_abnormal_lacrimal_gland0.67276173
159MP0003045_fibrosis0.67142525
160MP0001502_abnormal_circadian_rhythm0.65495732
161MP0005645_abnormal_hypothalamus_physiol0.64489288
162MP0003935_abnormal_craniofacial_develop0.64080584
163MP0005551_abnormal_eye_electrophysiolog0.63638216
164MP0001853_heart_inflammation0.61937302
165MP0003880_abnormal_central_pattern0.61894186
166MP0010307_abnormal_tumor_latency0.60314951
167MP0004811_abnormal_neuron_physiology0.58753532
168MP0003861_abnormal_nervous_system0.58127037

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.38001507
2Volvulus (HP:0002580)4.10363963
3Abnormality of chromosome stability (HP:0003220)3.57281236
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.17075191
5Meckel diverticulum (HP:0002245)3.12459337
6Abnormality of the ileum (HP:0001549)3.07982105
7Febrile seizures (HP:0002373)2.90739380
8Inappropriate behavior (HP:0000719)2.75834062
9Absent frontal sinuses (HP:0002688)2.68967316
10Macroorchidism (HP:0000053)2.64514882
11Abnormality of the preputium (HP:0100587)2.61597343
12Birth length less than 3rd percentile (HP:0003561)2.61538897
13Abnormal hair whorl (HP:0010721)2.60508424
14Intestinal atresia (HP:0011100)2.58165201
15Nephroblastoma (Wilms tumor) (HP:0002667)2.55458926
16Small intestinal stenosis (HP:0012848)2.55306539
17Duodenal stenosis (HP:0100867)2.55306539
18Ectopic kidney (HP:0000086)2.51468825
19Epileptic encephalopathy (HP:0200134)2.48118634
20Embryonal renal neoplasm (HP:0011794)2.45144033
21Sloping forehead (HP:0000340)2.44339639
22Chronic hepatic failure (HP:0100626)2.42844981
23Acute myeloid leukemia (HP:0004808)2.41738360
24Abnormality of the duodenum (HP:0002246)2.41289719
25Spinal cord lesions (HP:0100561)2.40570612
26Syringomyelia (HP:0003396)2.40570612
27Tubulointerstitial nephritis (HP:0001970)2.40017149
28Clubbing of toes (HP:0100760)2.38853353
29Disinhibition (HP:0000734)2.38359987
30Narrow palate (HP:0000189)2.37281665
31Abnormality of the nasal septum (HP:0000419)2.35986453
32Protruding tongue (HP:0010808)2.34351502
33Short 4th metacarpal (HP:0010044)2.31389970
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31389970
35Aqueductal stenosis (HP:0002410)2.29694039
36Nephronophthisis (HP:0000090)2.27472517
37Retrobulbar optic neuritis (HP:0100654)2.27086747
38Optic neuritis (HP:0100653)2.27086747
39Long eyelashes (HP:0000527)2.27020586
40Myelodysplasia (HP:0002863)2.26685398
41Colon cancer (HP:0003003)2.24875680
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.24021876
43Severe combined immunodeficiency (HP:0004430)2.21334565
44Absent radius (HP:0003974)2.21188395
45Hepatoblastoma (HP:0002884)2.20926620
46Impaired smooth pursuit (HP:0007772)2.15594837
47Lip pit (HP:0100267)2.15160790
48Excessive salivation (HP:0003781)2.14913383
49Drooling (HP:0002307)2.14913383
50Combined immunodeficiency (HP:0005387)2.14372041
51Abnormality of the labia minora (HP:0012880)2.14308463
52Abnormal lung lobation (HP:0002101)2.14061522
53Abnormality of ocular smooth pursuit (HP:0000617)2.13765873
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.13671405
55Absent forearm bone (HP:0003953)2.11741529
56Aplasia involving forearm bones (HP:0009822)2.11741529
57Rhabdomyosarcoma (HP:0002859)2.11078434
58Abnormality of the astrocytes (HP:0100707)2.10874083
59Astrocytoma (HP:0009592)2.10874083
60Thyroiditis (HP:0100646)2.10752129
61Abnormality of the carotid arteries (HP:0005344)2.08676391
62Triphalangeal thumb (HP:0001199)2.07004195
63Trigonocephaly (HP:0000243)2.06393768
64Chromsome breakage (HP:0040012)2.06111023
65Gaze-evoked nystagmus (HP:0000640)2.05487873
66Glioma (HP:0009733)2.05435156
67Panhypogammaglobulinemia (HP:0003139)2.03874428
68Genetic anticipation (HP:0003743)1.99227848
69Abnormality of midbrain morphology (HP:0002418)1.98964865
70Molar tooth sign on MRI (HP:0002419)1.98964865
71Abnormal biliary tract physiology (HP:0012439)1.97222605
72Bile duct proliferation (HP:0001408)1.97222605
73Cafe-au-lait spot (HP:0000957)1.96402787
74Obsessive-compulsive behavior (HP:0000722)1.96401016
75Supernumerary ribs (HP:0005815)1.95690626
76Abnormality of the renal medulla (HP:0100957)1.95262587
77Sandal gap (HP:0001852)1.93573594
78High anterior hairline (HP:0009890)1.91482792
79Agammaglobulinemia (HP:0004432)1.91335118
80Recurrent fungal infections (HP:0002841)1.91235081
81True hermaphroditism (HP:0010459)1.90325081
82Pancreatic cysts (HP:0001737)1.89827604
83Recurrent viral infections (HP:0004429)1.89676363
84Pancreatic fibrosis (HP:0100732)1.89295012
85Patellar aplasia (HP:0006443)1.89228699
86Truncal obesity (HP:0001956)1.88993712
87Papillary thyroid carcinoma (HP:0002895)1.88016585
88Gonadotropin excess (HP:0000837)1.86172075
89Increased nuchal translucency (HP:0010880)1.85853053
90Tented upper lip vermilion (HP:0010804)1.85175744
91Progressive cerebellar ataxia (HP:0002073)1.84517341
92Bifid tongue (HP:0010297)1.83386464
93Oligodactyly (hands) (HP:0001180)1.83012858
94Chronic mucocutaneous candidiasis (HP:0002728)1.82739629
95Recurrent cutaneous fungal infections (HP:0011370)1.82739629
96Cystic hygroma (HP:0000476)1.81800251
97Abnormality of DNA repair (HP:0003254)1.81735128
98Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80531423
99Depressed nasal tip (HP:0000437)1.80471915
100Abnormality of chromosome segregation (HP:0002916)1.80023406
101Abnormality of cochlea (HP:0000375)1.79980912
102Heterotopia (HP:0002282)1.79401204
103Neoplasm of the oral cavity (HP:0100649)1.77464881
104Duplicated collecting system (HP:0000081)1.77184692
105Embryonal neoplasm (HP:0002898)1.77164799
106Ependymoma (HP:0002888)1.76005745
107Optic nerve coloboma (HP:0000588)1.75908145
108Abnormality of the parietal bone (HP:0002696)1.75760683
109Myositis (HP:0100614)1.75397287
110Hypoplasia of the maxilla (HP:0000327)1.73641782
111Cortical dysplasia (HP:0002539)1.73327027
112Preaxial hand polydactyly (HP:0001177)1.72718283
113Blue irides (HP:0000635)1.72185731
114Neoplasm of striated muscle (HP:0009728)1.70840359
115Postaxial foot polydactyly (HP:0001830)1.70365698
116Hematochezia (HP:0002573)1.69963264
117Supernumerary bones of the axial skeleton (HP:0009144)1.69332137
118Prominent nose (HP:0000448)1.69299771
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69271500
120Reticulocytopenia (HP:0001896)1.68905722
121Thyroid carcinoma (HP:0002890)1.68704886
122Deep philtrum (HP:0002002)1.68656786
123Impulsivity (HP:0100710)1.67984705
124Aplasia/Hypoplasia of the patella (HP:0006498)1.67274395
125Gastrointestinal atresia (HP:0002589)1.67140393
126Highly arched eyebrow (HP:0002553)1.66655881
127Astigmatism (HP:0000483)1.65403167
128Broad-based gait (HP:0002136)1.65294771
12911 pairs of ribs (HP:0000878)1.64271874
130Arteriovenous malformation (HP:0100026)1.63202278
131Long clavicles (HP:0000890)1.62603337
132IgM deficiency (HP:0002850)1.61585073
133Hypoplastic labia majora (HP:0000059)1.61045730
134Abnormality of the right ventricle (HP:0001707)1.60615381
135Poor coordination (HP:0002370)1.60533673
136Hypoplasia of the thymus (HP:0000778)1.60394226
137Cerebellar dysplasia (HP:0007033)1.60060048
138Arterial thrombosis (HP:0004420)1.59900407
139Orchitis (HP:0100796)1.59272060
140Anal stenosis (HP:0002025)1.58930724
141Thick eyebrow (HP:0000574)1.58243726
142Hypoplastic iliac wings (HP:0002866)1.58152669
143Abnormality of the renal collecting system (HP:0004742)1.58056576
144B lymphocytopenia (HP:0010976)1.55874026
145Abnormality of B cell number (HP:0010975)1.55874026
146Acute lymphatic leukemia (HP:0006721)1.55789746
147Pulmonary infiltrates (HP:0002113)1.55535862
148Abnormality of the frontal sinuses (HP:0002687)1.54858383
149Smooth philtrum (HP:0000319)1.54458407
150Neoplasm of the adrenal cortex (HP:0100641)1.54031696
151Midline defect of the nose (HP:0004122)1.53827575
152T lymphocytopenia (HP:0005403)1.53123762
153Abnormality of salivation (HP:0100755)1.52932199
154Medulloblastoma (HP:0002885)1.52918618
155Abnormality of the incisor (HP:0000676)1.52057142
156Vasculitis (HP:0002633)1.50706500
157Cutis marmorata (HP:0000965)1.50559801
158Chest pain (HP:0100749)1.50181423
159Meningitis (HP:0001287)1.49566113
160Septo-optic dysplasia (HP:0100842)1.49521850
161Focal motor seizures (HP:0011153)1.49284782
162Mediastinal lymphadenopathy (HP:0100721)1.47478407
163Inflammation of the large intestine (HP:0002037)1.47401788
164Chronic diarrhea (HP:0002028)1.46627850
165Fair hair (HP:0002286)1.46263083
166Abnormality of T cell number (HP:0011839)1.45613356
167Urethral obstruction (HP:0000796)1.45544018
168Generalized hypopigmentation of hair (HP:0011358)1.44456504
169Increased number of teeth (HP:0011069)1.44390974
170Stomach cancer (HP:0012126)1.44143808
171Widely spaced teeth (HP:0000687)1.43059646
172Ureteral stenosis (HP:0000071)1.43007467
173Prolonged bleeding time (HP:0003010)1.42855710
174High pitched voice (HP:0001620)1.41762022
175Macrotia (HP:0000400)1.41329668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K142.84053418
2MKNK22.82386110
3BRD42.73562178
4TXK2.72741552
5PRPF4B2.42460229
6CDK122.36888635
7MKNK12.30430299
8MAP2K72.29388872
9PNCK2.19109361
10MAP3K42.18740557
11CAMK1G2.18363008
12PLK42.09116106
13EIF2AK32.08512879
14WEE12.04450452
15BRSK22.00414300
16TTK1.88851044
17WNK31.87921629
18CDK31.87532107
19MAP3K131.83842974
20SIK21.82971075
21SIK31.77477670
22CAMK1D1.74289450
23WNK11.56145546
24SGK21.54402438
25TNIK1.49116550
26MAP4K11.47727284
27YES11.44488032
28TRIM281.44195568
29ERBB31.41584537
30FGFR31.40128495
31LATS11.38288300
32BCR1.38215622
33PLK31.37952603
34SGK31.32559421
35CASK1.27770320
36STK391.26805798
37JAK11.26658653
38CHEK21.25131196
39KSR11.24682740
40CDK81.23743473
41CHUK1.19856963
42RIPK11.16458076
43PLK11.13803093
44CDC71.13140427
45ZAK1.12831027
46TEC1.12629169
47DYRK31.11884143
48NTRK21.10831113
49CDK91.10395827
50ATR1.10171888
51SRPK11.08275672
52TYK21.07682059
53HIPK21.01890073
54MAPK131.01294494
55SGK11.00163695
56FGFR20.94147260
57ALK0.93170478
58IKBKE0.92331974
59STK30.92009741
60TNK20.91765402
61CSNK1G10.90494518
62STK38L0.89958410
63INSRR0.89865853
64NUAK10.89453504
65IRAK40.88391017
66NLK0.88168677
67CDK60.88035907
68IKBKB0.86725818
69ATM0.85886094
70MAP2K40.84241594
71JAK30.84044672
72RAF10.83592437
73CDK40.83503118
74EPHA40.83267497
75CAMKK20.82562933
76NTRK30.80279607
77BUB10.80243140
78TAOK30.80090148
79ITK0.78350819
80NEK60.78342095
81DYRK1A0.77814902
82CDK70.77203739
83MELK0.75394344
84NEK20.75154731
85RPS6KB10.74452405
86CAMK40.73807176
87EIF2AK10.73180278
88SGK2230.73075604
89SGK4940.73075604
90KIT0.72751330
91LCK0.71303620
92PTK60.70698883
93CLK10.70542200
94EPHB10.69681173
95PASK0.68264962
96MARK20.67634631
97TRPM70.67145452
98EIF2AK20.67037355
99PLK20.66727083
100MAP3K70.64770617
101CHEK10.64338753
102CSNK1A1L0.64187137
103MAPK140.62982323
104MARK30.62828222
105CSNK1G20.62810641
106PRKAA20.62549151
107HCK0.61862392
108EEF2K0.60997073
109PRKDC0.60581685
110OXSR10.60494507
111FES0.60114999
112RIPK40.60064927
113FGFR10.60005933
114MAP4K20.59814437
115CSNK1G30.59596038
116STK110.59059846
117BTK0.59047361
118AKT30.59020325
119RPS6KA40.58880242
120TSSK60.58798717
121WNK40.57340015
122MARK10.56578687
123CSNK1E0.56545761
124GSK3B0.56228670
125CDC42BPA0.56121552
126RPS6KB20.55768650
127CSF1R0.55757490
128KSR20.55243110
129CDK20.52767031
130BMPR1B0.52530327
131TYRO30.51840136
132NEK10.51608515
133CSNK1D0.50367219
134MAPK80.50363380
135BRSK10.50251455
136AURKB0.50084194
137PBK0.50060676
138VRK10.50026248
139MAP3K100.49846121
140CDK10.45706754
141MAPK100.45657187
142EPHA30.44623458
143AKT10.44196077
144PDK20.43552277
145TGFBR10.42927429
146RPS6KA30.42811697
147PIM10.42548869
148PRKCQ0.42096243
149PDGFRB0.41509518
150FRK0.40769693
151ACVR1B0.40619360
152MAP3K20.40438276
153IRAK10.36628139

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.12532795
2DNA replication_Homo sapiens_hsa030303.04897986
3RNA transport_Homo sapiens_hsa030132.89961191
4Spliceosome_Homo sapiens_hsa030402.56726107
5Basal transcription factors_Homo sapiens_hsa030222.19286846
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13882814
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11773195
8Base excision repair_Homo sapiens_hsa034101.95277620
9Autoimmune thyroid disease_Homo sapiens_hsa053201.85908442
10Allograft rejection_Homo sapiens_hsa053301.84094975
11Nucleotide excision repair_Homo sapiens_hsa034201.81506971
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.77697972
13Nicotine addiction_Homo sapiens_hsa050331.75504474
14Primary immunodeficiency_Homo sapiens_hsa053401.72956429
15T cell receptor signaling pathway_Homo sapiens_hsa046601.63570097
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.63171646
17Oocyte meiosis_Homo sapiens_hsa041141.59698152
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59159072
19Propanoate metabolism_Homo sapiens_hsa006401.55863027
20One carbon pool by folate_Homo sapiens_hsa006701.44515159
21Asthma_Homo sapiens_hsa053101.41910672
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35467592
23Morphine addiction_Homo sapiens_hsa050321.35031758
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.34484906
25Glutamatergic synapse_Homo sapiens_hsa047241.33246629
26B cell receptor signaling pathway_Homo sapiens_hsa046621.31649112
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28814869
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28755339
29Circadian entrainment_Homo sapiens_hsa047131.28698336
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28593903
31p53 signaling pathway_Homo sapiens_hsa041151.27418164
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24852348
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24462723
34Herpes simplex infection_Homo sapiens_hsa051681.24093830
35Long-term potentiation_Homo sapiens_hsa047201.22517750
36Measles_Homo sapiens_hsa051621.21902042
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.20257440
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17490919
39Osteoclast differentiation_Homo sapiens_hsa043801.16950537
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15746873
41Type II diabetes mellitus_Homo sapiens_hsa049301.15721675
42Chemokine signaling pathway_Homo sapiens_hsa040621.14259204
43Selenocompound metabolism_Homo sapiens_hsa004501.12226503
44Hedgehog signaling pathway_Homo sapiens_hsa043401.11619787
45Basal cell carcinoma_Homo sapiens_hsa052171.09976631
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.05497409
47Olfactory transduction_Homo sapiens_hsa047401.03693433
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03132539
49Leishmaniasis_Homo sapiens_hsa051401.02327972
50TNF signaling pathway_Homo sapiens_hsa046681.02267246
51Toxoplasmosis_Homo sapiens_hsa051451.01948188
52Fanconi anemia pathway_Homo sapiens_hsa034601.01745724
53mRNA surveillance pathway_Homo sapiens_hsa030151.01709146
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01095620
55Hematopoietic cell lineage_Homo sapiens_hsa046400.99670424
56Chronic myeloid leukemia_Homo sapiens_hsa052200.98788454
57Hepatitis B_Homo sapiens_hsa051610.98004767
58Taste transduction_Homo sapiens_hsa047420.96711687
59Lysine degradation_Homo sapiens_hsa003100.95813079
60Colorectal cancer_Homo sapiens_hsa052100.94608554
61Influenza A_Homo sapiens_hsa051640.94402888
62Long-term depression_Homo sapiens_hsa047300.94275289
63GABAergic synapse_Homo sapiens_hsa047270.93924889
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93037216
65Non-homologous end-joining_Homo sapiens_hsa034500.92526732
66Dorso-ventral axis formation_Homo sapiens_hsa043200.92157026
67MAPK signaling pathway_Homo sapiens_hsa040100.91649410
68cAMP signaling pathway_Homo sapiens_hsa040240.90120078
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88162991
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87577265
71TGF-beta signaling pathway_Homo sapiens_hsa043500.87291108
72ErbB signaling pathway_Homo sapiens_hsa040120.87274128
73Regulation of autophagy_Homo sapiens_hsa041400.86550140
74Acute myeloid leukemia_Homo sapiens_hsa052210.86223432
75Steroid biosynthesis_Homo sapiens_hsa001000.85823455
76Pancreatic cancer_Homo sapiens_hsa052120.85675301
77MicroRNAs in cancer_Homo sapiens_hsa052060.85257600
78Cholinergic synapse_Homo sapiens_hsa047250.83088426
79Amphetamine addiction_Homo sapiens_hsa050310.83059172
80FoxO signaling pathway_Homo sapiens_hsa040680.82735269
81Phototransduction_Homo sapiens_hsa047440.82419772
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82267790
83HTLV-I infection_Homo sapiens_hsa051660.82167364
84Dopaminergic synapse_Homo sapiens_hsa047280.81311331
85Homologous recombination_Homo sapiens_hsa034400.81064915
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78413755
87Hippo signaling pathway_Homo sapiens_hsa043900.78185867
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78141836
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77017444
90mTOR signaling pathway_Homo sapiens_hsa041500.76006877
91Salivary secretion_Homo sapiens_hsa049700.75808502
92Calcium signaling pathway_Homo sapiens_hsa040200.75563870
93Inositol phosphate metabolism_Homo sapiens_hsa005620.75520241
94Renin secretion_Homo sapiens_hsa049240.75379580
95Oxytocin signaling pathway_Homo sapiens_hsa049210.75359588
96Small cell lung cancer_Homo sapiens_hsa052220.75247143
97Prolactin signaling pathway_Homo sapiens_hsa049170.74980339
98Butanoate metabolism_Homo sapiens_hsa006500.74382262
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.73383624
100Platelet activation_Homo sapiens_hsa046110.73320145
101Non-small cell lung cancer_Homo sapiens_hsa052230.73003027
102Axon guidance_Homo sapiens_hsa043600.72612132
103Ether lipid metabolism_Homo sapiens_hsa005650.71445014
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71061027
105Wnt signaling pathway_Homo sapiens_hsa043100.70659100
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70522518
107Tuberculosis_Homo sapiens_hsa051520.69264589
108Fatty acid biosynthesis_Homo sapiens_hsa000610.68928849
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68654101
110Endometrial cancer_Homo sapiens_hsa052130.68423950
111Viral myocarditis_Homo sapiens_hsa054160.67383450
112Choline metabolism in cancer_Homo sapiens_hsa052310.67120947
113Notch signaling pathway_Homo sapiens_hsa043300.65080536
114Apoptosis_Homo sapiens_hsa042100.64990088
115Glioma_Homo sapiens_hsa052140.64582989
116RNA degradation_Homo sapiens_hsa030180.64443029
117Circadian rhythm_Homo sapiens_hsa047100.64186376
118Type I diabetes mellitus_Homo sapiens_hsa049400.63498347
119Cell cycle_Homo sapiens_hsa041100.63225538
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62770583
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62652065
122RNA polymerase_Homo sapiens_hsa030200.62310214
123Prostate cancer_Homo sapiens_hsa052150.62189364
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61228667
125Antigen processing and presentation_Homo sapiens_hsa046120.61020877
126Gastric acid secretion_Homo sapiens_hsa049710.60878935
127Melanoma_Homo sapiens_hsa052180.60680421
128Viral carcinogenesis_Homo sapiens_hsa052030.60541693
129Shigellosis_Homo sapiens_hsa051310.60285666
130Alcoholism_Homo sapiens_hsa050340.59798949
131Rap1 signaling pathway_Homo sapiens_hsa040150.59611529
132Serotonergic synapse_Homo sapiens_hsa047260.59319211
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59078958
134Adherens junction_Homo sapiens_hsa045200.58258594
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57984848
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57975700
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56965011
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54876164
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54314023
140Purine metabolism_Homo sapiens_hsa002300.53014074
141Nitrogen metabolism_Homo sapiens_hsa009100.51303946
142Thyroid cancer_Homo sapiens_hsa052160.48564847
143Fatty acid metabolism_Homo sapiens_hsa012120.48238195
144Protein export_Homo sapiens_hsa030600.45148950
145Pyrimidine metabolism_Homo sapiens_hsa002400.39112325
146Melanogenesis_Homo sapiens_hsa049160.35769415
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33105426
148Glucagon signaling pathway_Homo sapiens_hsa049220.29372744
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27995005
150Linoleic acid metabolism_Homo sapiens_hsa005910.27512441
151Pathways in cancer_Homo sapiens_hsa052000.26611968
152Pyruvate metabolism_Homo sapiens_hsa006200.25455672
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23571353
154Renal cell carcinoma_Homo sapiens_hsa052110.21395664
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.21195726

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »