PAXIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.13857965
2nuclear pore complex assembly (GO:0051292)5.02089120
3DNA unwinding involved in DNA replication (GO:0006268)4.89828660
4nuclear pore organization (GO:0006999)4.79987228
5DNA replication checkpoint (GO:0000076)4.67263823
6DNA replication initiation (GO:0006270)4.44924813
7protein localization to chromosome, centromeric region (GO:0071459)4.28928285
8regulation of DNA methylation (GO:0044030)4.28630163
9DNA strand elongation involved in DNA replication (GO:0006271)4.24873711
10mitotic sister chromatid segregation (GO:0000070)4.18349232
11mitotic sister chromatid cohesion (GO:0007064)4.11355685
12telomere maintenance via semi-conservative replication (GO:0032201)4.10169966
13sister chromatid segregation (GO:0000819)4.09174853
14DNA strand elongation (GO:0022616)4.08108084
15histone H4-K12 acetylation (GO:0043983)4.01132718
16regulation of centriole replication (GO:0046599)3.99392694
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.96904171
18regulation of centrosome cycle (GO:0046605)3.92719628
19mitotic nuclear envelope disassembly (GO:0007077)3.88615343
20DNA duplex unwinding (GO:0032508)3.87334532
21DNA geometric change (GO:0032392)3.86284895
22* positive regulation of histone H3-K4 methylation (GO:0051571)3.85851928
23mitotic chromosome condensation (GO:0007076)3.85457519
24telomere maintenance via recombination (GO:0000722)3.85297244
25mitotic recombination (GO:0006312)3.84636279
26kinetochore organization (GO:0051383)3.81277865
27pore complex assembly (GO:0046931)3.80609154
28translesion synthesis (GO:0019985)3.80036755
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73160259
30DNA replication-dependent nucleosome organization (GO:0034723)3.71240667
31DNA replication-dependent nucleosome assembly (GO:0006335)3.71240667
32meiotic cell cycle (GO:0051321)3.69460551
33pre-miRNA processing (GO:0031054)3.61794073
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61247971
35nuclear envelope disassembly (GO:0051081)3.58665153
36membrane disassembly (GO:0030397)3.58665153
37heterochromatin organization (GO:0070828)3.53325569
38sister chromatid cohesion (GO:0007062)3.53289263
39mitotic metaphase plate congression (GO:0007080)3.53173624
40* regulation of histone H3-K4 methylation (GO:0051569)3.48774789
41kinetochore assembly (GO:0051382)3.48165367
42DNA topological change (GO:0006265)3.46943370
43DNA synthesis involved in DNA repair (GO:0000731)3.40537957
44DNA replication-independent nucleosome organization (GO:0034724)3.40286976
45DNA replication-independent nucleosome assembly (GO:0006336)3.40286976
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.39769826
47folic acid-containing compound biosynthetic process (GO:0009396)3.39442038
48centriole replication (GO:0007099)3.38300212
49histone H4-K5 acetylation (GO:0043981)3.36231556
50histone H4-K8 acetylation (GO:0043982)3.36231556
51regulation of sister chromatid cohesion (GO:0007063)3.32620498
52telomere maintenance via telomere lengthening (GO:0010833)3.29626346
53chromatin remodeling at centromere (GO:0031055)3.29494620
54chromatin assembly or disassembly (GO:0006333)3.29379030
55CENP-A containing nucleosome assembly (GO:0034080)3.28609736
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28301912
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28301912
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.28301912
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27534945
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26476473
61metaphase plate congression (GO:0051310)3.25760513
62DNA strand renaturation (GO:0000733)3.25344811
63glucocorticoid receptor signaling pathway (GO:0042921)3.23226099
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.22675178
65DNA conformation change (GO:0071103)3.22531791
66regulation of mitotic sister chromatid separation (GO:0010965)3.22504457
67regulation of mitotic sister chromatid segregation (GO:0033047)3.22504457
68regulation of sister chromatid segregation (GO:0033045)3.22504457
69regulation of centrosome duplication (GO:0010824)3.20629083
70regulation of RNA export from nucleus (GO:0046831)3.20196134
71* regulation of histone methylation (GO:0031060)3.19908669
72chromatin assembly (GO:0031497)3.19151738
73positive regulation of chromosome segregation (GO:0051984)3.18955025
74regulation of spindle checkpoint (GO:0090231)3.18224885
75protein localization to chromosome (GO:0034502)3.14919484
76ribosome assembly (GO:0042255)3.12330648
77mitotic spindle checkpoint (GO:0071174)3.12140556
78dosage compensation (GO:0007549)3.11648264
79chromosome condensation (GO:0030261)3.10929335
80mitotic G2/M transition checkpoint (GO:0044818)3.10660033
81inner cell mass cell proliferation (GO:0001833)3.09350744
82IMP biosynthetic process (GO:0006188)3.07770540
83double-strand break repair via homologous recombination (GO:0000724)3.07050387
84meiotic chromosome segregation (GO:0045132)3.06938034
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05867863
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.05867863
87negative regulation of sister chromatid segregation (GO:0033046)3.05867863
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05867863
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05867863
90attachment of spindle microtubules to kinetochore (GO:0008608)3.05285016
91gene silencing by RNA (GO:0031047)3.04614716
92histone-serine phosphorylation (GO:0035404)3.04517938
93establishment of chromosome localization (GO:0051303)3.03668820
94ATP-dependent chromatin remodeling (GO:0043044)3.03333589
95recombinational repair (GO:0000725)3.03036453
96intra-S DNA damage checkpoint (GO:0031573)3.02715876
97* positive regulation of histone methylation (GO:0031062)3.01755064
98regulation of histone H3-K9 methylation (GO:0051570)3.01259964
99negative regulation of histone methylation (GO:0031061)3.00459934
100DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.98462215
101regulation of DNA endoreduplication (GO:0032875)2.97131164
102histone H4-K16 acetylation (GO:0043984)2.94142983
103negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.93913854
104nucleosome disassembly (GO:0006337)2.93774296
105protein-DNA complex disassembly (GO:0032986)2.93774296
106negative regulation of mRNA processing (GO:0050686)2.93177421
107regulation of DNA-dependent DNA replication (GO:0090329)2.93114759
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92652167
109chromosome segregation (GO:0007059)2.92207368
110spindle assembly checkpoint (GO:0071173)2.91634028
111postreplication repair (GO:0006301)2.91203369
112negative regulation of cell cycle G2/M phase transition (GO:1902750)2.90175703
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.90132499
114regulation of chromosome segregation (GO:0051983)2.90035488
115negative regulation of RNA splicing (GO:0033119)2.89281039
116spindle checkpoint (GO:0031577)2.88204961
117replication fork processing (GO:0031297)2.87876825
118telomere maintenance (GO:0000723)2.87745797
119regulation of double-strand break repair via homologous recombination (GO:0010569)2.87529887
120negative regulation of chromosome segregation (GO:0051985)2.86817122
121DNA damage response, signal transduction resulting in transcription (GO:0042772)2.86316918
122regulation of spindle organization (GO:0090224)2.85431440
123positive regulation of DNA-dependent DNA replication (GO:2000105)2.85127106
124telomere organization (GO:0032200)2.84929969
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84121190
126nucleobase biosynthetic process (GO:0046112)2.84039023
127regulation of telomere maintenance via telomerase (GO:0032210)2.83356845
128mismatch repair (GO:0006298)2.82960877
129histone exchange (GO:0043486)2.80419362
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80135533
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.80135533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.66206780
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49310334
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.74335065
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.99290528
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.88188775
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63097132
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.61171274
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.51961416
9MYC_22102868_ChIP-Seq_BL_Human2.45396015
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36170541
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35654467
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32059799
13CIITA_25753668_ChIP-Seq_RAJI_Human2.27705241
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19767114
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19465108
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14287539
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03669629
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01798835
19E2F7_22180533_ChIP-Seq_HELA_Human12.3991174
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88467177
21EZH2_22144423_ChIP-Seq_EOC_Human1.87627736
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.86387293
23AR_21909140_ChIP-Seq_LNCAP_Human1.82871973
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82097623
25XRN2_22483619_ChIP-Seq_HELA_Human1.81514318
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70396862
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69217543
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63774609
29FOXP3_21729870_ChIP-Seq_TREG_Human1.62624972
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61675320
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61048159
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58549923
33KDM5A_27292631_Chip-Seq_BREAST_Human1.50776141
34VDR_23849224_ChIP-Seq_CD4+_Human1.50674019
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.49193705
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45784801
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44803718
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43366071
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42423853
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41159509
41VDR_21846776_ChIP-Seq_THP-1_Human1.40577038
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39920841
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.39738853
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39352576
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37504472
46TTF2_22483619_ChIP-Seq_HELA_Human1.37217723
47* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37032534
48GABP_19822575_ChIP-Seq_HepG2_Human1.35741584
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33392727
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31019674
51* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29854871
52EWS_26573619_Chip-Seq_HEK293_Human1.29292232
53MYC_18940864_ChIP-ChIP_HL60_Human1.28914652
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28289151
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27524884
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.26310201
57DCP1A_22483619_ChIP-Seq_HELA_Human1.25436488
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24677875
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23451571
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.22982070
61* ELK1_19687146_ChIP-ChIP_HELA_Human1.21406048
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21128779
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20682509
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20391115
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18683448
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18438747
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18145493
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17999585
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17454510
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17104842
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16882419
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14842737
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.13334510
74SCL_19346495_ChIP-Seq_HPC-7_Human1.12451851
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.10274617
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09389218
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08767330
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08048688
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07568465
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07269427
81TFEB_21752829_ChIP-Seq_HELA_Human1.06290375
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03251199
83* TCF7_22412390_ChIP-Seq_EML_Mouse1.02944420
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02835285
85* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00438011
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99840154
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99006988
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98752956
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98333801
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93159449
91IRF1_19129219_ChIP-ChIP_H3396_Human0.92203923
92FUS_26573619_Chip-Seq_HEK293_Human0.91625427
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90860530
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90480047
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89773231
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89478529
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86557708
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86201698
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85520144
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85520144
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85520144
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85102890
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84424597
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82069909
105MYB_26560356_Chip-Seq_TH2_Human0.81558219
106* MYB_26560356_Chip-Seq_TH1_Human0.81546564
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81399066
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78707001
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77243488
110UTX_26944678_Chip-Seq_JUKART_Human0.77208233
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.76999916
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76374450
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75815466
114SPI1_23547873_ChIP-Seq_NB4_Human0.75720458
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75699118
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74363863
117ZNF274_21170338_ChIP-Seq_K562_Hela0.71246285
118CHD1_26751641_Chip-Seq_LNCaP_Human0.69446281
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.65906565
120GATA1_22025678_ChIP-Seq_K562_Human0.63055627
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.57712074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.25187295
2MP0003693_abnormal_embryo_hatching4.17445750
3MP0003111_abnormal_nucleus_morphology4.02523071
4* MP0008057_abnormal_DNA_replication3.89448333
5MP0003718_maternal_effect3.74986264
6* MP0003077_abnormal_cell_cycle3.40393874
7MP0004957_abnormal_blastocyst_morpholog3.19596067
8* MP0008058_abnormal_DNA_repair2.68952977
9MP0003890_abnormal_embryonic-extraembry2.67550410
10MP0002396_abnormal_hematopoietic_system2.61247498
11MP0003121_genomic_imprinting2.50029757
12MP0006292_abnormal_olfactory_placode2.23424594
13MP0005076_abnormal_cell_differentiation2.21026799
14MP0003123_paternal_imprinting2.13875086
15* MP0000350_abnormal_cell_proliferation2.04448523
16MP0008007_abnormal_cellular_replicative2.03490979
17MP0003283_abnormal_digestive_organ2.03092154
18MP0000569_abnormal_digit_pigmentation2.02032686
19MP0010352_gastrointestinal_tract_polyps2.00919109
20MP0003122_maternal_imprinting1.97226286
21MP0004264_abnormal_extraembryonic_tissu1.85850466
22* MP0001730_embryonic_growth_arrest1.84491552
23* MP0008932_abnormal_embryonic_tissue1.83234035
24* MP0005380_embryogenesis_phenotype1.80218421
25* MP0001672_abnormal_embryogenesis/_devel1.80218421
26MP0001293_anophthalmia1.74739945
27MP0003950_abnormal_plasma_membrane1.74147155
28MP0008877_abnormal_DNA_methylation1.69433225
29* MP0002085_abnormal_embryonic_tissue1.69061083
30* MP0002084_abnormal_developmental_patter1.66446191
31* MP0003984_embryonic_growth_retardation1.64796365
32MP0000490_abnormal_crypts_of1.64706724
33MP0003787_abnormal_imprinting1.63556010
34MP0004197_abnormal_fetal_growth/weight/1.62655654
35* MP0002088_abnormal_embryonic_growth/wei1.61388115
36MP0010307_abnormal_tumor_latency1.60215023
37MP0004808_abnormal_hematopoietic_stem1.58272606
38* MP0001697_abnormal_embryo_size1.52360615
39MP0000678_abnormal_parathyroid_gland1.46207462
40MP0003119_abnormal_digestive_system1.43572501
41MP0004133_heterotaxia1.41956001
42* MP0002086_abnormal_extraembryonic_tissu1.41472518
43MP0002877_abnormal_melanocyte_morpholog1.40302758
44MP0005395_other_phenotype1.39879745
45MP0009697_abnormal_copulation1.37988314
46MP0003699_abnormal_female_reproductive1.37189488
47MP0004147_increased_porphyrin_level1.36938835
48* MP0002080_prenatal_lethality1.36819136
49MP0003763_abnormal_thymus_physiology1.36781474
50MP0009703_decreased_birth_body1.36531141
51MP0002009_preneoplasia1.35988065
52MP0010030_abnormal_orbit_morphology1.35519535
53MP0000703_abnormal_thymus_morphology1.33267043
54* MP0000313_abnormal_cell_death1.31472268
55MP0003786_premature_aging1.24932407
56MP0000653_abnormal_sex_gland1.19983653
57MP0003941_abnormal_skin_development1.18550039
58MP0009672_abnormal_birth_weight1.15491196
59MP0008961_abnormal_basal_metabolism1.15228934
60MP0009053_abnormal_anal_canal1.14935859
61MP0002019_abnormal_tumor_incidence1.14699077
62MP0001119_abnormal_female_reproductive1.09782160
63MP0004233_abnormal_muscle_weight1.06478169
64MP0002160_abnormal_reproductive_system1.04796203
65MP0008995_early_reproductive_senescence1.02389918
66MP0002938_white_spotting1.02199945
67MP0003935_abnormal_craniofacial_develop1.00803611
68MP0000428_abnormal_craniofacial_morphol1.00292952
69MP0002398_abnormal_bone_marrow0.97937438
70MP0005075_abnormal_melanosome_morpholog0.96520673
71MP0010678_abnormal_skin_adnexa0.94750284
72MP0003646_muscle_fatigue0.94531678
73MP0001286_abnormal_eye_development0.94199265
74MP0003942_abnormal_urinary_system0.93290335
75MP0000537_abnormal_urethra_morphology0.93193277
76MP0002092_abnormal_eye_morphology0.92616511
77MP0002161_abnormal_fertility/fecundity0.91773739
78MP0005499_abnormal_olfactory_system0.91070898
79MP0005394_taste/olfaction_phenotype0.91070898
80MP0002932_abnormal_joint_morphology0.90424114
81MP0002751_abnormal_autonomic_nervous0.90308397
82MP0003567_abnormal_fetal_cardiomyocyte0.89621430
83MP0002653_abnormal_ependyma_morphology0.88144077
84MP0003115_abnormal_respiratory_system0.86912730
85MP0000631_abnormal_neuroendocrine_gland0.86907333
86MP0003698_abnormal_male_reproductive0.86297868
87MP0000432_abnormal_head_morphology0.85330627
88MP0003937_abnormal_limbs/digits/tail_de0.84550736
89MP0006054_spinal_hemorrhage0.84236571
90MP0004185_abnormal_adipocyte_glucose0.83449258
91MP0002210_abnormal_sex_determination0.82628188
92MP0002722_abnormal_immune_system0.82557447
93MP0000427_abnormal_hair_cycle0.82090885
94MP0009278_abnormal_bone_marrow0.79043525
95MP0002697_abnormal_eye_size0.78827316
96MP0002111_abnormal_tail_morphology0.78588928
97MP0002116_abnormal_craniofacial_bone0.77184110
98MP0000049_abnormal_middle_ear0.77168839
99MP0003861_abnormal_nervous_system0.76917674
100MP0003755_abnormal_palate_morphology0.75774708
101MP0001849_ear_inflammation0.75579294
102MP0000358_abnormal_cell_content/0.75383284
103MP0003943_abnormal_hepatobiliary_system0.74926609
104* MP0005384_cellular_phenotype0.74631492
105MP0002234_abnormal_pharynx_morphology0.74555664
106MP0002075_abnormal_coat/hair_pigmentati0.74434987
107* MP0002925_abnormal_cardiovascular_devel0.74201048
108MP0001145_abnormal_male_reproductive0.72666932
109* MP0005621_abnormal_cell_physiology0.71731012
110MP0003315_abnormal_perineum_morphology0.71625669
111MP0005389_reproductive_system_phenotype0.71291291
112MP0001545_abnormal_hematopoietic_system0.70590407
113MP0005397_hematopoietic_system_phenotyp0.70590407
114MP0001929_abnormal_gametogenesis0.70477508
115MP0003656_abnormal_erythrocyte_physiolo0.69982040
116MP0000371_diluted_coat_color0.69211982
117MP0005174_abnormal_tail_pigmentation0.69161045
118MP0000689_abnormal_spleen_morphology0.68484242
119MP0006035_abnormal_mitochondrial_morpho0.68401930
120MP0000383_abnormal_hair_follicle0.67902201
121MP0001919_abnormal_reproductive_system0.67848775
122MP0005647_abnormal_sex_gland0.64822182
123MP0002163_abnormal_gland_morphology0.64613475
124MP0000613_abnormal_salivary_gland0.64509168
125MP0001186_pigmentation_phenotype0.64414444
126MP0004381_abnormal_hair_follicle0.63438378
127MP0001346_abnormal_lacrimal_gland0.63296393
128MP0002138_abnormal_hepatobiliary_system0.62731357
129MP0002429_abnormal_blood_cell0.62528569
130MP0000566_synostosis0.62383805
131MP0002233_abnormal_nose_morphology0.60722653
132MP0002006_tumorigenesis0.60138195
133MP0003136_yellow_coat_color0.59155774
134MP0000372_irregular_coat_pigmentation0.56740261
135MP0004043_abnormal_pH_regulation0.56512402
136MP0008789_abnormal_olfactory_epithelium0.55974155
137MP0005310_abnormal_salivary_gland0.55341608

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25337030
2Chromsome breakage (HP:0040012)4.23376328
3Volvulus (HP:0002580)3.63345091
4Ependymoma (HP:0002888)3.35473359
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.31474050
6Abnormal number of incisors (HP:0011064)3.29381839
7Abnormality of the fingertips (HP:0001211)3.14153436
8Abnormality of chromosome stability (HP:0003220)3.08348602
9Medulloblastoma (HP:0002885)2.95170552
10Ectopic kidney (HP:0000086)2.93609991
11Long eyelashes (HP:0000527)2.89502376
12Clubbing of toes (HP:0100760)2.84486301
13Birth length less than 3rd percentile (HP:0003561)2.81086078
14Patellar aplasia (HP:0006443)2.77554096
15Meckel diverticulum (HP:0002245)2.76848607
16Increased nuchal translucency (HP:0010880)2.74425000
17Abnormality of the ileum (HP:0001549)2.73218598
18Abnormality of the labia minora (HP:0012880)2.67725053
19Duplicated collecting system (HP:0000081)2.66347858
20Prominent nose (HP:0000448)2.62380667
21Absent forearm bone (HP:0003953)2.60140426
22Facial hemangioma (HP:0000329)2.55007019
23Renal duplication (HP:0000075)2.53914797
24Aplasia/Hypoplasia of the patella (HP:0006498)2.51411324
25Premature ovarian failure (HP:0008209)2.48680555
26Nephroblastoma (Wilms tumor) (HP:0002667)2.46127525
27Acute myeloid leukemia (HP:0004808)2.45492725
28Glioma (HP:0009733)2.45201891
29Impulsivity (HP:0100710)2.43945139
30Short thumb (HP:0009778)2.41335040
31Duodenal stenosis (HP:0100867)2.41127842
32Small intestinal stenosis (HP:0012848)2.41127842
33Astrocytoma (HP:0009592)2.38555435
34Abnormality of the astrocytes (HP:0100707)2.38555435
35Absent thumb (HP:0009777)2.38326054
36Myelodysplasia (HP:0002863)2.36844326
37Urethral obstruction (HP:0000796)2.36629608
38Rhabdomyosarcoma (HP:0002859)2.34863830
39Short middle phalanx of the 5th finger (HP:0004220)2.34530740
40Dysmetric saccades (HP:0000641)2.33369307
41Abnormality of chromosome segregation (HP:0002916)2.31191734
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30859493
43Short 4th metacarpal (HP:0010044)2.30859493
44Abnormality of the preputium (HP:0100587)2.30664557
45Abnormality of the anterior horn cell (HP:0006802)2.30480828
46Degeneration of anterior horn cells (HP:0002398)2.30480828
47Anal stenosis (HP:0002025)2.29660010
48Intestinal atresia (HP:0011100)2.27929217
49Neoplasm of striated muscle (HP:0009728)2.27374129
50Embryonal renal neoplasm (HP:0011794)2.25342641
51Selective tooth agenesis (HP:0001592)2.25314653
52Horseshoe kidney (HP:0000085)2.22283325
53Abnormality of abdominal situs (HP:0011620)2.21567550
54Abdominal situs inversus (HP:0003363)2.21567550
55Triphalangeal thumb (HP:0001199)2.21099335
56Microvesicular hepatic steatosis (HP:0001414)2.18035265
57Neoplasm of the oral cavity (HP:0100649)2.17709951
58Embryonal neoplasm (HP:0002898)2.16425632
59Abnormality of the duodenum (HP:0002246)2.15182283
60Rib fusion (HP:0000902)2.14722400
61Abnormality of the carotid arteries (HP:0005344)2.14544105
62Choanal atresia (HP:0000453)2.13946861
63Abnormality of the pons (HP:0007361)2.12743144
64Bilateral microphthalmos (HP:0007633)2.09979136
65Limb hypertonia (HP:0002509)2.09651257
66Acute lymphatic leukemia (HP:0006721)2.06995899
67Arteriovenous malformation (HP:0100026)2.05824256
68Deviation of the thumb (HP:0009603)2.05559865
69Sloping forehead (HP:0000340)2.02505276
70Skin tags (HP:0010609)2.01851089
71Capillary hemangiomas (HP:0005306)2.01245534
72Deep philtrum (HP:0002002)2.00996410
73Cafe-au-lait spot (HP:0000957)2.00972949
74Broad thumb (HP:0011304)2.00544207
75Optic nerve coloboma (HP:0000588)2.00419570
76Preauricular skin tag (HP:0000384)2.00217290
77Abnormality of the incisor (HP:0000676)1.99418446
7811 pairs of ribs (HP:0000878)1.98838568
79Abnormality of DNA repair (HP:0003254)1.98775396
80Short 5th finger (HP:0009237)1.97609841
81Trigonocephaly (HP:0000243)1.96912848
82Hypoplasia of the pons (HP:0012110)1.96747636
83Proximal placement of thumb (HP:0009623)1.96608819
84Missing ribs (HP:0000921)1.95974643
85Abnormality of homocysteine metabolism (HP:0010919)1.95309437
86Homocystinuria (HP:0002156)1.95309437
87Reticulocytopenia (HP:0001896)1.94872760
88Abnormality of endocrine pancreas physiology (HP:0012093)1.94410266
89Abnormality of the pancreatic islet cells (HP:0006476)1.94410266
90Spinal muscular atrophy (HP:0007269)1.93561654
91Abnormality of the septum pellucidum (HP:0007375)1.92848000
92Poikiloderma (HP:0001029)1.92258949
93Multiple enchondromatosis (HP:0005701)1.91228088
94Septate vagina (HP:0001153)1.90263449
95Abnormal lung lobation (HP:0002101)1.88581947
96Hypoplastic labia majora (HP:0000059)1.87758938
97Prominent metopic ridge (HP:0005487)1.87597275
98Intestinal fistula (HP:0100819)1.87475053
99Spinal cord lesions (HP:0100561)1.86585742
100Syringomyelia (HP:0003396)1.86585742
101Hypochromic microcytic anemia (HP:0004840)1.86319295
102Neoplasm of the adrenal cortex (HP:0100641)1.86080663
103Breast hypoplasia (HP:0003187)1.86014642
104Gonadotropin excess (HP:0000837)1.85806817
105Hepatoblastoma (HP:0002884)1.85279055
106Abnormality of the renal collecting system (HP:0004742)1.83582276
107Abnormality of cochlea (HP:0000375)1.83349646
108Abnormality of the metopic suture (HP:0005556)1.83126124
109Short philtrum (HP:0000322)1.82052334
110Pancreatic islet-cell hyperplasia (HP:0004510)1.81821967
111Sandal gap (HP:0001852)1.79961590
112Supernumerary spleens (HP:0009799)1.78729420
113Progressive inability to walk (HP:0002505)1.78309514
114Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77750550
115Absent radius (HP:0003974)1.77644271
116Supernumerary ribs (HP:0005815)1.76604511
117Bone marrow hypocellularity (HP:0005528)1.76260457
118Atresia of the external auditory canal (HP:0000413)1.76067699
119Progressive external ophthalmoplegia (HP:0000590)1.75671879
120Supernumerary bones of the axial skeleton (HP:0009144)1.73475282
121Colon cancer (HP:0003003)1.71322991
122Cleft eyelid (HP:0000625)1.71197704
123Broad phalanges of the hand (HP:0009768)1.71086167
124Basal cell carcinoma (HP:0002671)1.71030112
125Tracheoesophageal fistula (HP:0002575)1.69893592
126Broad palm (HP:0001169)1.69342309
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.69136933
128Long palpebral fissure (HP:0000637)1.69053741
129High pitched voice (HP:0001620)1.68985635
130Heterotopia (HP:0002282)1.68611891
131Facial cleft (HP:0002006)1.68088582
132Truncal obesity (HP:0001956)1.67996444
133High anterior hairline (HP:0009890)1.67891147
134Protruding tongue (HP:0010808)1.67846897
135Macroorchidism (HP:0000053)1.67830126
136Absent septum pellucidum (HP:0001331)1.67580820
137Deep palmar crease (HP:0006191)1.67524111
138Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67340572
139Aplastic anemia (HP:0001915)1.66852960
140Papillary thyroid carcinoma (HP:0002895)1.66836555
141Lip pit (HP:0100267)1.66424072
142Abnormality of the intervertebral disk (HP:0005108)1.66381264
143Hyperacusis (HP:0010780)1.65596212
144Obsessive-compulsive behavior (HP:0000722)1.65371283
145Oligodactyly (hands) (HP:0001180)1.65133244
146Aplasia involving forearm bones (HP:0009822)1.65011371
147Duplication of thumb phalanx (HP:0009942)1.64284642
148Ureteral duplication (HP:0000073)1.62129717
149Fair hair (HP:0002286)1.61917428
150Skull defect (HP:0001362)1.58681804
151Secondary amenorrhea (HP:0000869)1.57602836
152Squamous cell carcinoma (HP:0002860)1.57112990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.91858484
2CDC74.38497422
3SIK33.48321363
4NEK22.61697609
5PASK2.61552799
6WEE12.45258253
7TTK2.33223317
8MAP3K92.21692101
9BRD42.20832199
10MAP3K102.15478958
11ATR2.08420790
12BRSK22.03163303
13CDK71.90283957
14PLK11.85633156
15BUB11.84200480
16VRK21.83201635
17STK101.79463771
18MAP3K131.74085669
19ACVR1B1.73720944
20CAMK1G1.72656646
21SRPK11.69229237
22BRSK11.68641371
23CHEK21.66142600
24SMG11.57842149
25CHEK11.54311103
26EEF2K1.50932250
27FRK1.48312739
28BMPR1B1.47082655
29TLK11.44612707
30NUAK11.42754777
31PBK1.42685532
32KSR11.42388053
33AURKB1.41376634
34PLK41.39697256
35TAF11.38220858
36CDK41.36114723
37TSSK61.26477591
38ATM1.24195011
39TRIM281.23291202
40EIF2AK31.20528588
41ERN11.19714137
42CDK21.14513147
43PLK31.13431215
44ZAK1.12673395
45MAP3K81.10095178
46MTOR1.09697214
47BRAF1.06547164
48UHMK11.04771032
49STK41.04333778
50ICK1.00506589
51TAOK21.00162367
52MELK0.98527534
53PNCK0.98069046
54BCR0.97326720
55CHUK0.94616090
56MST40.94487635
57WNK10.94440519
58DYRK30.94088809
59EIF2AK10.92754175
60VRK10.89553845
61RPS6KB20.89227201
62CDK10.88813509
63PRPF4B0.88527186
64TNIK0.87563379
65STK30.86962209
66PIM10.83970488
67WNK40.81630778
68MAP4K10.81274882
69ALK0.78927647
70NEK60.77926679
71NME10.77498993
72AURKA0.76682475
73PDGFRA0.76189034
74RPS6KA40.74557733
75IRAK40.74267578
76MKNK10.73355469
77CDK60.71783691
78RAF10.71396498
79GRK60.70207133
80LATS10.69209339
81PAK40.68227099
82HIPK20.67869350
83CCNB10.67051702
84NEK10.65692992
85CLK10.64355425
86JAK30.64056091
87MUSK0.62727943
88MAPK140.62710879
89EPHA20.61382142
90AKT30.61376534
91PRKD30.61328474
92TRIB30.57671759
93STK390.57013852
94FLT30.55261335
95MKNK20.54993104
96CSF1R0.54457045
97BTK0.52392531
98AKT10.51728303
99TAOK30.51204254
100IRAK30.50486964
101PRKDC0.50148047
102CAMK1D0.50094472
103MAPK110.49868685
104AKT20.47396010
105TGFBR10.47011785
106ERBB20.46774699
107GSK3B0.45752203
108CDC42BPA0.44863841
109ITK0.44803559
110MAPKAPK20.44085528
111CDK90.42540543
112EIF2AK20.41767745
113CDK80.41721704
114PDK20.40717191
115NLK0.39303119
116RPS6KB10.39186992
117MATK0.38801350
118IRAK10.38525750
119CDK30.38221950
120ZAP700.38176487
121CSNK1D0.38118056
122CSNK1E0.38018657
123MAPK10.37882512
124PRKCI0.36600646
125KSR20.36413560
126INSRR0.35870041
127CSNK1G10.35292295
128TYRO30.34756195
129DMPK0.34072282
130CSNK2A20.33066825
131DAPK10.32427063
132CSNK2A10.30358456
133MAPK100.29201821

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60663254
2Mismatch repair_Homo sapiens_hsa034303.75489599
3Cell cycle_Homo sapiens_hsa041103.14118408
4Base excision repair_Homo sapiens_hsa034102.94590288
5Spliceosome_Homo sapiens_hsa030402.75305789
6RNA transport_Homo sapiens_hsa030132.72649830
7Homologous recombination_Homo sapiens_hsa034402.67265450
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66373427
9Fanconi anemia pathway_Homo sapiens_hsa034602.50962336
10One carbon pool by folate_Homo sapiens_hsa006702.43064826
11mRNA surveillance pathway_Homo sapiens_hsa030152.32416060
12Non-homologous end-joining_Homo sapiens_hsa034502.27789211
13Nucleotide excision repair_Homo sapiens_hsa034202.27160192
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91053887
15RNA degradation_Homo sapiens_hsa030181.85810632
16RNA polymerase_Homo sapiens_hsa030201.78076965
17Pyrimidine metabolism_Homo sapiens_hsa002401.70261257
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.62240262
19p53 signaling pathway_Homo sapiens_hsa041151.55248566
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.51190478
21Basal transcription factors_Homo sapiens_hsa030221.33730367
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30663832
23MicroRNAs in cancer_Homo sapiens_hsa052061.30361801
24Basal cell carcinoma_Homo sapiens_hsa052171.25685827
25Herpes simplex infection_Homo sapiens_hsa051681.25592721
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24552610
27Oocyte meiosis_Homo sapiens_hsa041141.20312840
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17409564
29Viral carcinogenesis_Homo sapiens_hsa052031.16379639
30HTLV-I infection_Homo sapiens_hsa051661.16273706
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13764590
32Notch signaling pathway_Homo sapiens_hsa043301.12422403
33Epstein-Barr virus infection_Homo sapiens_hsa051691.08904086
34N-Glycan biosynthesis_Homo sapiens_hsa005101.02815978
35Chronic myeloid leukemia_Homo sapiens_hsa052201.02577167
36Lysine degradation_Homo sapiens_hsa003101.01265633
37Systemic lupus erythematosus_Homo sapiens_hsa053221.00017970
38Primary immunodeficiency_Homo sapiens_hsa053400.95390611
39Antigen processing and presentation_Homo sapiens_hsa046120.93497615
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93018448
41Proteasome_Homo sapiens_hsa030500.90481305
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.89648724
43Thyroid cancer_Homo sapiens_hsa052160.88665932
44Purine metabolism_Homo sapiens_hsa002300.88610774
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88206744
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88168745
47Hedgehog signaling pathway_Homo sapiens_hsa043400.88006311
48Propanoate metabolism_Homo sapiens_hsa006400.84051849
49Hippo signaling pathway_Homo sapiens_hsa043900.84017981
50Hepatitis B_Homo sapiens_hsa051610.82560123
51Ribosome_Homo sapiens_hsa030100.80309657
52Small cell lung cancer_Homo sapiens_hsa052220.79718340
53mTOR signaling pathway_Homo sapiens_hsa041500.78314310
54Adherens junction_Homo sapiens_hsa045200.76252841
55Colorectal cancer_Homo sapiens_hsa052100.75113994
56Wnt signaling pathway_Homo sapiens_hsa043100.73475656
57Prostate cancer_Homo sapiens_hsa052150.73400409
58Non-small cell lung cancer_Homo sapiens_hsa052230.73350403
59Fatty acid biosynthesis_Homo sapiens_hsa000610.73059037
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70760433
61Measles_Homo sapiens_hsa051620.70667729
62Alcoholism_Homo sapiens_hsa050340.70291521
63Folate biosynthesis_Homo sapiens_hsa007900.67197021
64Acute myeloid leukemia_Homo sapiens_hsa052210.66286452
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64252065
66Pancreatic cancer_Homo sapiens_hsa052120.63539327
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.62498973
68Selenocompound metabolism_Homo sapiens_hsa004500.61788809
69Protein export_Homo sapiens_hsa030600.59664859
70Pathways in cancer_Homo sapiens_hsa052000.58240377
71Apoptosis_Homo sapiens_hsa042100.57701052
72Endometrial cancer_Homo sapiens_hsa052130.56112020
73Type I diabetes mellitus_Homo sapiens_hsa049400.54124752
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53547264
75Influenza A_Homo sapiens_hsa051640.53426528
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52749125
77TGF-beta signaling pathway_Homo sapiens_hsa043500.52157604
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50360476
79Pyruvate metabolism_Homo sapiens_hsa006200.49986338
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48627973
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48396366
82T cell receptor signaling pathway_Homo sapiens_hsa046600.48262775
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47821708
84Viral myocarditis_Homo sapiens_hsa054160.46713905
85Bladder cancer_Homo sapiens_hsa052190.46279250
86Inositol phosphate metabolism_Homo sapiens_hsa005620.46231490
87Ovarian steroidogenesis_Homo sapiens_hsa049130.45980970
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44110762
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43823666
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43385266
91Vitamin B6 metabolism_Homo sapiens_hsa007500.43184927
92B cell receptor signaling pathway_Homo sapiens_hsa046620.42650917
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41328003
94Glioma_Homo sapiens_hsa052140.41125737
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40807443
96Proteoglycans in cancer_Homo sapiens_hsa052050.40360351
97Steroid biosynthesis_Homo sapiens_hsa001000.40168147
98Prolactin signaling pathway_Homo sapiens_hsa049170.39703795
99Phototransduction_Homo sapiens_hsa047440.38728029
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37056507
101Legionellosis_Homo sapiens_hsa051340.36149262
102FoxO signaling pathway_Homo sapiens_hsa040680.35584501
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.35284271
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34925119
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33173013
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31842524
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.31362365
108ABC transporters_Homo sapiens_hsa020100.31196470
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30657362
110Hematopoietic cell lineage_Homo sapiens_hsa046400.30403176
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29986627
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28902097
113Renal cell carcinoma_Homo sapiens_hsa052110.27914943
114Type II diabetes mellitus_Homo sapiens_hsa049300.27705914
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25754521
116Leishmaniasis_Homo sapiens_hsa051400.24720123
117Biosynthesis of amino acids_Homo sapiens_hsa012300.24699052
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24553332
119ErbB signaling pathway_Homo sapiens_hsa040120.24025157
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.23908994
121Olfactory transduction_Homo sapiens_hsa047400.22942010
122Dorso-ventral axis formation_Homo sapiens_hsa043200.22533405
123Circadian rhythm_Homo sapiens_hsa047100.21408460
124Melanoma_Homo sapiens_hsa052180.21267031
125Galactose metabolism_Homo sapiens_hsa000520.21209861
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20270014
127MAPK signaling pathway_Homo sapiens_hsa040100.19960700
128HIF-1 signaling pathway_Homo sapiens_hsa040660.16766682
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14136183

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