PBLD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.53833185
2exogenous drug catabolic process (GO:0042738)7.77037727
3drug catabolic process (GO:0042737)7.55036341
4drug metabolic process (GO:0017144)6.33139980
5omega-hydroxylase P450 pathway (GO:0097267)6.31011262
6cellular glucuronidation (GO:0052695)6.03861004
7uronic acid metabolic process (GO:0006063)5.85600753
8glucuronate metabolic process (GO:0019585)5.85600753
9angiotensin maturation (GO:0002003)5.81502032
10regulation of triglyceride catabolic process (GO:0010896)5.59650146
11ethanol oxidation (GO:0006069)5.54723799
12bile acid and bile salt transport (GO:0015721)5.37493185
13fat-soluble vitamin biosynthetic process (GO:0042362)5.30778528
14urea metabolic process (GO:0019627)5.10194542
15alkaloid metabolic process (GO:0009820)5.02713037
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.00126259
17intestinal absorption (GO:0050892)4.84444148
18bile acid metabolic process (GO:0008206)4.84148233
19glyoxylate metabolic process (GO:0046487)4.81284553
20nitrogen cycle metabolic process (GO:0071941)4.67218602
21oxidative demethylation (GO:0070989)4.66861511
22L-phenylalanine catabolic process (GO:0006559)4.60139697
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.60139697
24hormone catabolic process (GO:0042447)4.57298134
25urea cycle (GO:0000050)4.53386277
26flavonoid metabolic process (GO:0009812)4.51108981
27arginine metabolic process (GO:0006525)4.45330887
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45033367
29phenylpropanoid metabolic process (GO:0009698)4.38463350
30ethanol metabolic process (GO:0006067)4.38394703
31complement activation, alternative pathway (GO:0006957)4.30328291
32regulation of guanylate cyclase activity (GO:0031282)4.15100028
33L-phenylalanine metabolic process (GO:0006558)4.10124716
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.10124716
35lipoprotein transport (GO:0042953)4.09145538
36regulation of protein activation cascade (GO:2000257)4.07952254
37regulation of bile acid biosynthetic process (GO:0070857)4.04420361
38bile acid biosynthetic process (GO:0006699)3.98782321
39high-density lipoprotein particle remodeling (GO:0034375)3.95393377
40aromatic amino acid family catabolic process (GO:0009074)3.93210493
41regulation of fibrinolysis (GO:0051917)3.92372002
42regulation of complement activation (GO:0030449)3.90927964
43negative regulation of sterol transport (GO:0032372)3.80828396
44negative regulation of cholesterol transport (GO:0032375)3.80828396
45protein-lipid complex remodeling (GO:0034368)3.76095198
46macromolecular complex remodeling (GO:0034367)3.76095198
47plasma lipoprotein particle remodeling (GO:0034369)3.76095198
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.75060735
49heme transport (GO:0015886)3.72430394
50vitamin biosynthetic process (GO:0009110)3.68163863
51very-low-density lipoprotein particle assembly (GO:0034379)3.65958724
52fructose metabolic process (GO:0006000)3.63880399
53drug transmembrane transport (GO:0006855)3.59792920
54phospholipid efflux (GO:0033700)3.58144146
55amino-acid betaine metabolic process (GO:0006577)3.56825330
56cellular ketone body metabolic process (GO:0046950)3.56730521
57triglyceride homeostasis (GO:0070328)3.55514994
58acylglycerol homeostasis (GO:0055090)3.55514994
59reverse cholesterol transport (GO:0043691)3.55320305
60S-adenosylmethionine metabolic process (GO:0046500)3.53188794
61negative regulation of fibrinolysis (GO:0051918)3.50585296
62regulation of cholesterol esterification (GO:0010872)3.49705770
63positive regulation of triglyceride lipase activity (GO:0061365)3.48923388
64positive regulation of lipoprotein lipase activity (GO:0051006)3.48923388
65positive regulation of lipid catabolic process (GO:0050996)3.48287830
66NADH metabolic process (GO:0006734)3.47170756
67xenobiotic metabolic process (GO:0006805)3.45209197
68drug transport (GO:0015893)3.42558181
69lipoprotein metabolic process (GO:0042157)3.34012890
70diacylglycerol metabolic process (GO:0046339)3.33855053
71tryptophan catabolic process (GO:0006569)3.33717866
72indole-containing compound catabolic process (GO:0042436)3.33717866
73indolalkylamine catabolic process (GO:0046218)3.33717866
74regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.33542162
75endocrine process (GO:0050886)3.33542162
76regulation of systemic arterial blood pressure by hormone (GO:0001990)3.33542162
77complement activation, classical pathway (GO:0006958)3.32553386
78urate metabolic process (GO:0046415)3.27753743
79blood coagulation, intrinsic pathway (GO:0007597)3.23195497
80protein activation cascade (GO:0072376)3.22775159
81positive regulation of guanylate cyclase activity (GO:0031284)3.21747814
82renal system process involved in regulation of blood volume (GO:0001977)3.19349860
83negative regulation of blood coagulation (GO:0030195)3.18301324
84negative regulation of hemostasis (GO:1900047)3.18301324
85serine family amino acid catabolic process (GO:0009071)3.17224596
86cholesterol efflux (GO:0033344)3.16622268
87protein carboxylation (GO:0018214)3.14617726
88peptidyl-glutamic acid carboxylation (GO:0017187)3.14617726
89complement activation (GO:0006956)3.14140048
90ketone body metabolic process (GO:1902224)3.09741788
91vitamin transport (GO:0051180)3.09536334
92coenzyme catabolic process (GO:0009109)3.07174464
93phospholipid homeostasis (GO:0055091)3.07012998
94fibrinolysis (GO:0042730)3.06214078
95homocysteine metabolic process (GO:0050667)3.03531692
96glycerol metabolic process (GO:0006071)3.02660594
97primary alcohol metabolic process (GO:0034308)3.02288005
98cholesterol homeostasis (GO:0042632)3.01876097
99plasma lipoprotein particle organization (GO:0071827)3.01843198
100intestinal cholesterol absorption (GO:0030299)3.01014485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.04760346
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.08468842
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.43276677
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.23627019
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95111976
6CDX2_20551321_ChIP-Seq_CACO-2_Human2.82220902
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46171400
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28624707
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23600852
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01208355
11GATA4_25053715_ChIP-Seq_YYC3_Human1.99642052
12CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93404050
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91352839
14BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.89819334
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.81955029
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81853539
17VDR_22108803_ChIP-Seq_LS180_Human1.78803542
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71284183
19BCAT_22108803_ChIP-Seq_LS180_Human1.69166865
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58209158
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55436011
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54365003
23* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48126246
24CDX2_22108803_ChIP-Seq_LS180_Human1.45883531
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45647140
26* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43651404
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.43402740
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42650925
29HTT_18923047_ChIP-ChIP_STHdh_Human1.35361955
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32963878
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32555085
32SOX2_20726797_ChIP-Seq_SW620_Human1.30336438
33PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26951887
34ER_23166858_ChIP-Seq_MCF-7_Human1.25232833
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25203076
36AR_20517297_ChIP-Seq_VCAP_Human1.24703664
37* FOXA1_25552417_ChIP-Seq_VCAP_Human1.24176139
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23848450
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22721596
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22041603
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21937464
42* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21931894
43* FOXA2_19822575_ChIP-Seq_HepG2_Human1.21658887
44ZNF274_21170338_ChIP-Seq_K562_Hela1.20946550
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.20847671
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20784389
47GATA1_22025678_ChIP-Seq_K562_Human1.17741657
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17606669
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17299735
50GATA6_25053715_ChIP-Seq_YYC3_Human1.16936285
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15626282
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14286475
53TCF4_22108803_ChIP-Seq_LS180_Human1.13022592
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.12196203
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12196203
56GBX2_23144817_ChIP-Seq_PC3_Human1.08582494
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07780871
58P300_19829295_ChIP-Seq_ESCs_Human1.05685045
59CEBPB_22108803_ChIP-Seq_LS180_Human1.05538847
60IGF1R_20145208_ChIP-Seq_DFB_Human1.05311395
61* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03095378
62NCOR_22424771_ChIP-Seq_293T_Human1.01425253
63SOX2_19829295_ChIP-Seq_ESCs_Human1.00744564
64NANOG_19829295_ChIP-Seq_ESCs_Human1.00744564
65AR_25329375_ChIP-Seq_VCAP_Human1.00452251
66NFE2_27457419_Chip-Seq_LIVER_Mouse0.99230460
67NANOG_20526341_ChIP-Seq_ESCs_Human0.96919618
68TAF2_19829295_ChIP-Seq_ESCs_Human0.96868138
69IRF1_19129219_ChIP-ChIP_H3396_Human0.96095714
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95672207
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95625472
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94789701
73GATA3_21878914_ChIP-Seq_MCF-7_Human0.93406682
74EZH2_27294783_Chip-Seq_NPCs_Mouse0.93189599
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92905038
76STAT3_23295773_ChIP-Seq_U87_Human0.92692253
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92062022
78HNFA_21074721_ChIP-Seq_CACO-2_Human0.91940425
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91489771
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91378665
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91233274
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90941837
83CBP_20019798_ChIP-Seq_JUKART_Human0.90941837
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.90901652
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89957352
86TRIM28_21343339_ChIP-Seq_HEK293_Human0.89659978
87MYC_19829295_ChIP-Seq_ESCs_Human0.89612026
88* CBP_21632823_ChIP-Seq_H3396_Human0.88928270
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88904056
90PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88253701
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88162343
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88020339
93PHF8_20622853_ChIP-Seq_HELA_Human0.88016231
94DROSHA_22980978_ChIP-Seq_HELA_Human0.87364831
95NFYA_21822215_ChIP-Seq_K562_Human0.86721168
96RXR_22108803_ChIP-Seq_LS180_Human0.85984108
97ETV1_20927104_ChIP-Seq_GIST48_Human0.85588527
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.85058582
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84944477
100TCF4_23295773_ChIP-Seq_U87_Human0.84847940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.07265591
2MP0002139_abnormal_hepatobiliary_system6.87128794
3MP0005085_abnormal_gallbladder_physiolo5.85257123
4MP0005365_abnormal_bile_salt5.01948274
5MP0001666_abnormal_nutrient_absorption4.27175145
6MP0003195_calcinosis3.83692763
7MP0008875_abnormal_xenobiotic_pharmacok3.50317929
8MP0003252_abnormal_bile_duct3.29631571
9MP0004019_abnormal_vitamin_homeostasis3.12925699
10MP0010329_abnormal_lipoprotein_level2.96518200
11MP0002138_abnormal_hepatobiliary_system2.90814187
12MP0005332_abnormal_amino_acid2.68346514
13MP0003183_abnormal_peptide_metabolism2.60295647
14MP0003868_abnormal_feces_composition2.59214796
15MP0004147_increased_porphyrin_level2.47362255
16MP0002876_abnormal_thyroid_physiology2.40902891
17MP0009840_abnormal_foam_cell2.35044680
18MP0004043_abnormal_pH_regulation2.17840803
19MP0009643_abnormal_urine_homeostasis1.92822576
20MP0001764_abnormal_homeostasis1.92066078
21MP0002118_abnormal_lipid_homeostasis1.68740858
22MP0003806_abnormal_nucleotide_metabolis1.56045084
23MP0005636_abnormal_mineral_homeostasis1.51023061
24MP0005670_abnormal_white_adipose1.47332681
25MP0009379_abnormal_foot_pigmentation1.46544043
26MP0008872_abnormal_physiological_respon1.44418736
27MP0001756_abnormal_urination1.38604434
28MP0010155_abnormal_intestine_physiology1.36853470
29MP0000609_abnormal_liver_physiology1.31633370
30MP0004264_abnormal_extraembryonic_tissu1.28634372
31MP0003879_abnormal_hair_cell1.28620922
32MP0001664_abnormal_digestion1.26449433
33MP0001765_abnormal_ion_homeostasis1.25603994
34MP0000538_abnormal_urinary_bladder1.23944451
35MP0002136_abnormal_kidney_physiology1.18737343
36MP0003866_abnormal_defecation1.13233316
37MP0005535_abnormal_body_temperature1.12452452
38MP0009697_abnormal_copulation1.11339881
39MP0005448_abnormal_energy_balance1.07108639
40MP0001501_abnormal_sleep_pattern1.02372468
41MP0005584_abnormal_enzyme/coenzyme_acti1.02242303
42MP0005319_abnormal_enzyme/_coenzyme0.98755238
43MP0000230_abnormal_systemic_arterial0.98194424
44MP0002971_abnormal_brown_adipose0.97360920
45MP0003718_maternal_effect0.96752309
46MP0009642_abnormal_blood_homeostasis0.93748504
47MP0009764_decreased_sensitivity_to0.86452298
48MP0003011_delayed_dark_adaptation0.82997115
49MP0001663_abnormal_digestive_system0.79722720
50MP0003638_abnormal_response/metabolism_0.79673325
51MP0002078_abnormal_glucose_homeostasis0.79327763
52MP0008469_abnormal_protein_level0.71909123
53MP0003953_abnormal_hormone_level0.69162292
54MP0005376_homeostasis/metabolism_phenot0.68854032
55MP0005166_decreased_susceptibility_to0.65367145
56MP0005334_abnormal_fat_pad0.64772269
57MP0001485_abnormal_pinna_reflex0.64291453
58MP0001986_abnormal_taste_sensitivity0.64087399
59MP0005395_other_phenotype0.62161112
60MP0005409_darkened_coat_color0.61274482
61MP0005174_abnormal_tail_pigmentation0.60078456
62MP0010386_abnormal_urinary_bladder0.59552369
63MP0000477_abnormal_intestine_morphology0.59470242
64MP0005551_abnormal_eye_electrophysiolog0.59100658
65MP0003724_increased_susceptibility_to0.58490643
66MP0005381_digestive/alimentary_phenotyp0.58352698
67MP0002909_abnormal_adrenal_gland0.57481880
68MP0001845_abnormal_inflammatory_respons0.56820912
69MP0000598_abnormal_liver_morphology0.55176263
70MP0002822_catalepsy0.54683813
71MP0009785_altered_susceptibility_to0.54111551
72MP0000249_abnormal_blood_vessel0.53621791
73MP0003191_abnormal_cellular_cholesterol0.52421387
74MP0001188_hyperpigmentation0.49094475
75MP0002069_abnormal_eating/drinking_beha0.48041704
76MP0009115_abnormal_fat_cell0.47572545
77MP0002638_abnormal_pupillary_reflex0.46433584
78MP0009763_increased_sensitivity_to0.46370308
79MP0005408_hypopigmentation0.46036953
80MP0001873_stomach_inflammation0.45717444
81MP0000604_amyloidosis0.44829654
82MP0003283_abnormal_digestive_organ0.43325772
83MP0008775_abnormal_heart_ventricle0.43259008
84MP0005464_abnormal_platelet_physiology0.42691280
85MP0005266_abnormal_metabolism0.42298021
86MP0004782_abnormal_surfactant_physiolog0.41344098
87MP0002135_abnormal_kidney_morphology0.40967510
88MP0004885_abnormal_endolymph0.40524544
89MP0005645_abnormal_hypothalamus_physiol0.40390877
90MP0010234_abnormal_vibrissa_follicle0.39367677
91MP0009765_abnormal_xenobiotic_induced0.38063320
92MP0002098_abnormal_vibrissa_morphology0.36853840
93MP0000462_abnormal_digestive_system0.36485563
94MP0000566_synostosis0.35333810
95MP0000427_abnormal_hair_cycle0.34867067
96MP0000490_abnormal_crypts_of0.34410542
97MP0005367_renal/urinary_system_phenotyp0.33520528
98MP0000516_abnormal_urinary_system0.33520528
99MP0005187_abnormal_penis_morphology0.32163562
100MP0005084_abnormal_gallbladder_morpholo0.31889480

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.60619687
2Hypobetalipoproteinemia (HP:0003563)6.28489645
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.11389577
4Complement deficiency (HP:0004431)5.19590032
5Abnormality of proline metabolism (HP:0010907)4.98123095
6Hydroxyprolinuria (HP:0003080)4.98123095
7Systemic lupus erythematosus (HP:0002725)4.58095429
8Conjugated hyperbilirubinemia (HP:0002908)4.49315169
9Xanthomatosis (HP:0000991)4.32060658
10Prolonged partial thromboplastin time (HP:0003645)4.21774901
11Fat malabsorption (HP:0002630)4.17467389
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14840780
13Hyperlipoproteinemia (HP:0010980)4.11694434
14Abnormality of complement system (HP:0005339)4.07023069
15Hyperglycinuria (HP:0003108)4.01532767
16Abnormality of serine family amino acid metabolism (HP:0010894)3.87990599
17Abnormality of glycine metabolism (HP:0010895)3.87990599
18Metabolic alkalosis (HP:0200114)3.87360338
19Glycosuria (HP:0003076)3.81589122
20Abnormality of urine glucose concentration (HP:0011016)3.81589122
21Deep venous thrombosis (HP:0002625)3.73457586
22Alkalosis (HP:0001948)3.73450932
23Malnutrition (HP:0004395)3.68156245
24Abnormality of vitamin metabolism (HP:0100508)3.62946249
25Abnormality of the vitamin B12 metabolism (HP:0004341)3.52699620
26Abnormality of vitamin B metabolism (HP:0004340)3.50312586
27Proximal tubulopathy (HP:0000114)3.47437526
28Intrahepatic cholestasis (HP:0001406)3.39547123
29Glomerulonephritis (HP:0000099)3.36164546
30Hyperactive renin-angiotensin system (HP:0000841)3.31796931
31Generalized aminoaciduria (HP:0002909)3.30464459
32Hypolipoproteinemia (HP:0010981)3.23526622
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.19221456
34Epidermoid cyst (HP:0200040)3.10730459
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.10217438
36Hyperammonemia (HP:0001987)3.09773890
37Abnormality of pyrimidine metabolism (HP:0004353)3.02136605
38Widely patent fontanelles and sutures (HP:0004492)2.99568124
39Congenital sensorineural hearing impairment (HP:0008527)2.96489778
40Steatorrhea (HP:0002570)2.95283205
41Hyperglycinemia (HP:0002154)2.95057235
42Hyperphosphaturia (HP:0003109)2.94507980
43Decreased circulating renin level (HP:0003351)2.93453187
44Acanthocytosis (HP:0001927)2.93050044
45Potter facies (HP:0002009)2.92474815
46Facial shape deformation (HP:0011334)2.92474815
47Pigmentary retinal degeneration (HP:0001146)2.92323759
48Confusion (HP:0001289)2.91122664
49Abnormality of renin-angiotensin system (HP:0000847)2.91078260
50Delayed CNS myelination (HP:0002188)2.85077002
51Nephritis (HP:0000123)2.77592531
52Chronic diarrhea (HP:0002028)2.76856774
53Joint hemorrhage (HP:0005261)2.76743200
54Ileus (HP:0002595)2.76450836
55Nausea (HP:0002018)2.76237909
56Abnormality of nucleobase metabolism (HP:0010932)2.74761943
57Metabolic acidosis (HP:0001942)2.72866878
58Abnormality of purine metabolism (HP:0004352)2.62215223
59Abnormal urine phosphate concentration (HP:0012599)2.61383141
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.59636673
61Nephrolithiasis (HP:0000787)2.58701617
62Abnormality of magnesium homeostasis (HP:0004921)2.53710688
63Abnormality of serum amino acid levels (HP:0003112)2.46235284
64Vascular calcification (HP:0004934)2.41949453
65Increased circulating renin level (HP:0000848)2.40536600
66Rickets (HP:0002748)2.39294326
67Hyperuricemia (HP:0002149)2.37925234
68Increased purine levels (HP:0004368)2.37925234
69Hypokalemia (HP:0002900)2.33592486
70Cerebral palsy (HP:0100021)2.29415640
71Ketosis (HP:0001946)2.27569117
72Hyperaldosteronism (HP:0000859)2.24652354
73Hemorrhage of the eye (HP:0011885)2.24167869
74Hypophosphatemia (HP:0002148)2.24156725
75Lethargy (HP:0001254)2.22851123
76Hypomagnesemia (HP:0002917)2.21370208
77Megaloblastic anemia (HP:0001889)2.19530051
78Irritability (HP:0000737)2.18994935
79Focal segmental glomerulosclerosis (HP:0000097)2.16602264
80Poikilocytosis (HP:0004447)2.16202423
81Pancreatitis (HP:0001733)2.15661393
82Hypothermia (HP:0002045)2.15212046
83Abnormal urine output (HP:0012590)2.11074487
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08576485
85Dicarboxylic aciduria (HP:0003215)2.08576485
86Recurrent gram-negative bacterial infections (HP:0005420)2.08565950
87Cardiovascular calcification (HP:0011915)2.07216703
88Gout (HP:0001997)2.06425734
89Abnormality of renal excretion (HP:0011036)2.05030202
90Hyperventilation (HP:0002883)2.04808400
91Abnormality of chloride homeostasis (HP:0011422)2.04058680
92Abdominal distention (HP:0003270)1.99479693
93Hypophosphatemic rickets (HP:0004912)1.96585111
94Osteomalacia (HP:0002749)1.96158870
95Spontaneous abortion (HP:0005268)1.93642331
96Hypoglycemic coma (HP:0001325)1.91754483
97Fair hair (HP:0002286)1.90306626
98Renal cortical cysts (HP:0000803)1.89060204
99Vomiting (HP:0002013)1.87223675
100Ketoacidosis (HP:0001993)1.86525833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.02890777
2FRK3.47479357
3WNK33.36563802
4OXSR13.20333105
5STK392.72271544
6ERN12.14773005
7ADRBK22.13656189
8PIK3CA2.13159029
9WNK42.05035773
10TAOK32.03180135
11GRK11.99254850
12PRKG21.90196708
13INSRR1.88406406
14MST1R1.84148068
15MAP4K21.70513116
16BMPR1B1.58405972
17CASK1.54315239
18AKT31.53587831
19EPHA31.45308790
20MST41.34407630
21PINK11.28406077
22EPHB21.25785821
23DAPK21.23141292
24TNIK1.21783836
25MYLK1.16325384
26MAPKAPK31.15704376
27TYK21.08302709
28PRKAA21.06960851
29RIPK11.06817579
30CAMKK21.06595447
31MAP3K121.05277013
32PIK3CG1.04346099
33PRKACG1.03562899
34MAP2K61.01815335
35TXK1.00942564
36IRAK10.98051592
37MAP3K20.97191883
38ERBB20.96036455
39EPHA40.94868138
40EPHA20.92686877
41MUSK0.91987732
42NLK0.91515337
43MATK0.89238836
44GRK60.83869609
45SGK20.81708389
46MAP2K20.80547030
47PDK20.78942644
48PRKCZ0.77730605
49SGK4940.77722213
50SGK2230.77722213
51FER0.76453137
52ADRBK10.76036397
53TEC0.74778501
54STK240.74194129
55PRKCA0.73115579
56MET0.72356275
57PRKCE0.71878027
58MAPK130.71645595
59PAK30.69998928
60NUAK10.67274352
61NTRK30.66322920
62MAPK150.64699023
63PTK60.64496314
64MAP3K40.62834504
65CSF1R0.62702124
66IGF1R0.62414076
67PRKACA0.61434178
68MAPK110.61336997
69FGFR30.59679741
70TESK20.59192183
71PRKCQ0.57736178
72MAP4K10.57419013
73TLK10.56612674
74CAMK2D0.54844494
75DYRK1B0.52963108
76KIT0.51167495
77SYK0.50525354
78MAP2K40.49359270
79BMPR20.47190583
80PRKG10.47017694
81PTK2B0.46434033
82PRKAA10.46388944
83IKBKE0.45591029
84CSNK1A10.44795892
85ITK0.41487134
86PRKCG0.41424786
87FGFR40.40768909
88IKBKB0.40454534
89PDPK10.40399918
90BRSK20.39536414
91BCKDK0.38424451
92ABL20.37836529
93MAP2K10.37248433
94STK160.36756747
95CHUK0.36656921
96PIM10.36006642
97PRKCD0.35767581
98CAMK2A0.35463772
99PDK10.35002638
100MAP3K100.34454511

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.01371724
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45269488
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.33222322
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.17468929
5Retinol metabolism_Homo sapiens_hsa008303.09635369
6Chemical carcinogenesis_Homo sapiens_hsa052042.86731091
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71174546
8Fat digestion and absorption_Homo sapiens_hsa049752.71123173
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.69976777
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.57093653
11Linoleic acid metabolism_Homo sapiens_hsa005912.56508464
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.47351328
13Histidine metabolism_Homo sapiens_hsa003402.40467034
14Arginine biosynthesis_Homo sapiens_hsa002202.39548207
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.31191314
16Vitamin digestion and absorption_Homo sapiens_hsa049772.28913495
17Fatty acid degradation_Homo sapiens_hsa000712.15603965
18Starch and sucrose metabolism_Homo sapiens_hsa005002.06400990
19Tryptophan metabolism_Homo sapiens_hsa003802.04922880
20Complement and coagulation cascades_Homo sapiens_hsa046101.97181063
21Renin-angiotensin system_Homo sapiens_hsa046141.90826176
22Butanoate metabolism_Homo sapiens_hsa006501.88301626
23Bile secretion_Homo sapiens_hsa049761.86162806
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.80592567
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70738762
26Phenylalanine metabolism_Homo sapiens_hsa003601.68330004
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63946321
28PPAR signaling pathway_Homo sapiens_hsa033201.63663260
29Arachidonic acid metabolism_Homo sapiens_hsa005901.61456194
30Sulfur metabolism_Homo sapiens_hsa009201.56780412
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55068468
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50908036
33Tyrosine metabolism_Homo sapiens_hsa003501.50761473
34Mineral absorption_Homo sapiens_hsa049781.39603095
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36175807
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30890003
37Peroxisome_Homo sapiens_hsa041461.27940843
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26673945
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23097678
40Arginine and proline metabolism_Homo sapiens_hsa003301.19715618
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13910395
42Glycerolipid metabolism_Homo sapiens_hsa005611.05100385
43Protein digestion and absorption_Homo sapiens_hsa049741.02701287
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98646097
45beta-Alanine metabolism_Homo sapiens_hsa004100.95221502
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93598777
47Staphylococcus aureus infection_Homo sapiens_hsa051500.87948880
48Propanoate metabolism_Homo sapiens_hsa006400.87108531
49ABC transporters_Homo sapiens_hsa020100.81669108
50Fatty acid metabolism_Homo sapiens_hsa012120.78356181
51Fructose and mannose metabolism_Homo sapiens_hsa000510.76414767
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74372634
53Nitrogen metabolism_Homo sapiens_hsa009100.72336408
54Ether lipid metabolism_Homo sapiens_hsa005650.72302943
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67124930
56Galactose metabolism_Homo sapiens_hsa000520.66152290
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65562063
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59495046
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58450450
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56703220
61Pyruvate metabolism_Homo sapiens_hsa006200.55972153
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54616682
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47915082
64Metabolic pathways_Homo sapiens_hsa011000.46345104
65Glutathione metabolism_Homo sapiens_hsa004800.42871395
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.42738101
67Sulfur relay system_Homo sapiens_hsa041220.40678572
68Pancreatic secretion_Homo sapiens_hsa049720.37872122
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.36938317
70Serotonergic synapse_Homo sapiens_hsa047260.33065291
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.31370997
72Fatty acid biosynthesis_Homo sapiens_hsa000610.30844128
73Sphingolipid metabolism_Homo sapiens_hsa006000.30457245
74Asthma_Homo sapiens_hsa053100.29383644
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25908473
76Vitamin B6 metabolism_Homo sapiens_hsa007500.24826467
77Carbon metabolism_Homo sapiens_hsa012000.24523276
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24060705
79Biosynthesis of amino acids_Homo sapiens_hsa012300.24030935
80Insulin resistance_Homo sapiens_hsa049310.23392814
81Folate biosynthesis_Homo sapiens_hsa007900.22130375
82Fatty acid elongation_Homo sapiens_hsa000620.21537048
83Selenocompound metabolism_Homo sapiens_hsa004500.17215618
84One carbon pool by folate_Homo sapiens_hsa006700.12743558
85Ovarian steroidogenesis_Homo sapiens_hsa049130.12562247
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.12322385
87Insulin secretion_Homo sapiens_hsa049110.12174862
88Glucagon signaling pathway_Homo sapiens_hsa049220.08421311
89Pertussis_Homo sapiens_hsa051330.07790271
90Type I diabetes mellitus_Homo sapiens_hsa049400.06096428
91Allograft rejection_Homo sapiens_hsa053300.05642538
92Prion diseases_Homo sapiens_hsa050200.05479616
93Cocaine addiction_Homo sapiens_hsa050300.04082232
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03757886
95Graft-versus-host disease_Homo sapiens_hsa053320.03330738
96Autoimmune thyroid disease_Homo sapiens_hsa053200.02854455
97Renin secretion_Homo sapiens_hsa049240.02235166
98Thyroid hormone synthesis_Homo sapiens_hsa049180.02088873
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.01410738
100Lysine degradation_Homo sapiens_hsa00310-0.0474466

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