PBOV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)4.73087180
2L-fucose metabolic process (GO:0042354)4.73087180
3L-fucose catabolic process (GO:0042355)4.73087180
4DNA deamination (GO:0045006)4.60127320
5behavioral response to nicotine (GO:0035095)4.57074218
6axoneme assembly (GO:0035082)4.36527710
7regulation of cilium movement (GO:0003352)4.07172117
8response to pheromone (GO:0019236)3.65530599
9respiratory chain complex IV assembly (GO:0008535)3.64131329
10protein complex biogenesis (GO:0070271)3.56440962
11rRNA catabolic process (GO:0016075)3.56321722
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52937562
13cellular ketone body metabolic process (GO:0046950)3.49342502
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43117855
15water-soluble vitamin biosynthetic process (GO:0042364)3.42366945
16mitochondrial respiratory chain complex assembly (GO:0033108)3.40565459
17glycerophospholipid catabolic process (GO:0046475)3.40466681
18protein polyglutamylation (GO:0018095)3.36427889
19cytochrome complex assembly (GO:0017004)3.35826965
20regulation of hexokinase activity (GO:1903299)3.35099441
21regulation of glucokinase activity (GO:0033131)3.35099441
22tryptophan catabolic process (GO:0006569)3.30988804
23indole-containing compound catabolic process (GO:0042436)3.30988804
24indolalkylamine catabolic process (GO:0046218)3.30988804
25piRNA metabolic process (GO:0034587)3.20683309
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19411776
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.19411776
28NADH dehydrogenase complex assembly (GO:0010257)3.19411776
29detection of light stimulus involved in sensory perception (GO:0050962)3.17628613
30detection of light stimulus involved in visual perception (GO:0050908)3.17628613
31ketone body metabolic process (GO:1902224)3.17146746
32indolalkylamine metabolic process (GO:0006586)3.14148074
33kynurenine metabolic process (GO:0070189)3.08048082
34preassembly of GPI anchor in ER membrane (GO:0016254)3.04620873
35platelet dense granule organization (GO:0060155)3.02547693
36protein-cofactor linkage (GO:0018065)3.00471197
37maturation of 5.8S rRNA (GO:0000460)2.99020183
38L-methionine salvage (GO:0071267)2.99007821
39L-methionine biosynthetic process (GO:0071265)2.99007821
40amino acid salvage (GO:0043102)2.99007821
41tryptophan metabolic process (GO:0006568)2.97811536
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96364560
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94812899
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94812899
45photoreceptor cell maintenance (GO:0045494)2.92775335
46branched-chain amino acid catabolic process (GO:0009083)2.92209937
47protein K11-linked deubiquitination (GO:0035871)2.91958122
48negative regulation of telomere maintenance (GO:0032205)2.88606361
49retinal cone cell development (GO:0046549)2.86667998
50epithelial cilium movement (GO:0003351)2.84243879
51protein prenylation (GO:0018342)2.83830468
52prenylation (GO:0097354)2.83830468
53cilium morphogenesis (GO:0060271)2.82658099
54behavioral response to ethanol (GO:0048149)2.82578936
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82272888
56GPI anchor metabolic process (GO:0006505)2.79338900
57signal peptide processing (GO:0006465)2.79307120
58adaptation of signaling pathway (GO:0023058)2.76877245
59mannosylation (GO:0097502)2.74812339
60nephron epithelium morphogenesis (GO:0072088)2.70520718
61nephron tubule morphogenesis (GO:0072078)2.70520718
62inositol phosphate catabolic process (GO:0071545)2.69899539
63S-adenosylmethionine metabolic process (GO:0046500)2.69845784
64nonmotile primary cilium assembly (GO:0035058)2.68631393
65DNA demethylation (GO:0080111)2.67694621
66inositol phosphate dephosphorylation (GO:0046855)2.67087265
67phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67087265
68DNA methylation involved in gamete generation (GO:0043046)2.66683032
69protein neddylation (GO:0045116)2.66656522
70Golgi to endosome transport (GO:0006895)2.66441221
71regulation of action potential (GO:0098900)2.65828155
72male meiosis (GO:0007140)2.62222170
73methionine biosynthetic process (GO:0009086)2.58226970
74cornea development in camera-type eye (GO:0061303)2.58171794
75replication fork processing (GO:0031297)2.58139232
76cytidine metabolic process (GO:0046087)2.56834002
77cytidine catabolic process (GO:0006216)2.56834002
78cytidine deamination (GO:0009972)2.56834002
79negative regulation of multicellular organism growth (GO:0040015)2.56667687
80polyol catabolic process (GO:0046174)2.56445735
81glycosphingolipid biosynthetic process (GO:0006688)2.55299657
82reflex (GO:0060004)2.54756335
83dopamine transport (GO:0015872)2.54438575
84pseudouridine synthesis (GO:0001522)2.53722188
85regulation of neurotransmitter uptake (GO:0051580)2.52956588
86positive regulation of mitochondrial fission (GO:0090141)2.52853612
87acrosome reaction (GO:0007340)2.52551632
88regulation of microtubule-based movement (GO:0060632)2.50857234
89brain morphogenesis (GO:0048854)2.49781521
90alanine transport (GO:0032328)2.46113133
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45449992
92protein import into peroxisome matrix (GO:0016558)2.45072647
93cilium or flagellum-dependent cell motility (GO:0001539)2.43396089
94positive regulation of fatty acid transport (GO:2000193)2.43170722
95photoreceptor cell development (GO:0042461)2.42897500
96single strand break repair (GO:0000012)2.42701482
97positive regulation of prostaglandin secretion (GO:0032308)2.42674901
98neuronal action potential (GO:0019228)2.42281595
99tRNA processing (GO:0008033)2.41903397
100regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.41798871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.81193888
2VDR_22108803_ChIP-Seq_LS180_Human3.46496025
3GBX2_23144817_ChIP-Seq_PC3_Human2.88939967
4IGF1R_20145208_ChIP-Seq_DFB_Human2.63440611
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59879027
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45350328
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34823701
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32334558
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.31863465
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27043705
11FUS_26573619_Chip-Seq_HEK293_Human2.13426294
12P300_19829295_ChIP-Seq_ESCs_Human2.05287202
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02568250
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98062149
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97136963
16EWS_26573619_Chip-Seq_HEK293_Human1.92934741
17ER_23166858_ChIP-Seq_MCF-7_Human1.91293981
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89908554
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87592665
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86511183
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84833668
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.82432121
23IRF1_19129219_ChIP-ChIP_H3396_Human1.79057205
24TAF15_26573619_Chip-Seq_HEK293_Human1.78228252
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77458552
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73449696
27CBP_20019798_ChIP-Seq_JUKART_Human1.63719141
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63719141
29* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62766860
30TP53_22573176_ChIP-Seq_HFKS_Human1.61912229
31BCAT_22108803_ChIP-Seq_LS180_Human1.59874776
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.59849378
33* PIAS1_25552417_ChIP-Seq_VCAP_Human1.59548043
34EZH2_22144423_ChIP-Seq_EOC_Human1.55623617
35STAT3_23295773_ChIP-Seq_U87_Human1.53938870
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49168295
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48230782
38SMAD4_21799915_ChIP-Seq_A2780_Human1.47433993
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.44882155
40* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44720756
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44099091
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.42298207
43* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41423735
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39435018
45TCF4_23295773_ChIP-Seq_U87_Human1.39280214
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38931552
47* TCF4_22108803_ChIP-Seq_LS180_Human1.38514818
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38315185
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37451988
50NANOG_19829295_ChIP-Seq_ESCs_Human1.34820121
51SOX2_19829295_ChIP-Seq_ESCs_Human1.34820121
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.32812764
53MYC_18940864_ChIP-ChIP_HL60_Human1.32358773
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32136562
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30775674
56* AR_25329375_ChIP-Seq_VCAP_Human1.30069310
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.29614321
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29191688
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28119189
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27486394
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26564117
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.26450737
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26450737
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25792423
65VDR_23849224_ChIP-Seq_CD4+_Human1.23895826
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23641822
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.23508794
68RUNX2_22187159_ChIP-Seq_PCA_Human1.23158475
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.22774548
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22732776
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22105646
72RNF2_27304074_Chip-Seq_NSC_Mouse1.21626249
73* SMAD4_21741376_ChIP-Seq_EPCs_Human1.20087525
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19871374
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17912153
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17358866
77CDX2_22108803_ChIP-Seq_LS180_Human1.16725160
78NCOR_22424771_ChIP-Seq_293T_Human1.16402829
79AR_20517297_ChIP-Seq_VCAP_Human1.16177044
80ELK1_19687146_ChIP-ChIP_HELA_Human1.15157775
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14922393
82REST_21632747_ChIP-Seq_MESCs_Mouse1.11501611
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10994759
84HTT_18923047_ChIP-ChIP_STHdh_Human1.10966696
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.10724105
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.08664036
87P53_22387025_ChIP-Seq_ESCs_Mouse1.08113964
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.07257619
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.07246364
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.05892081
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05431460
92HOXB7_26014856_ChIP-Seq_BT474_Human1.04833252
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04594626
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02755641
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02755641
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01789126
97EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00742464
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00730458
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99743366
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99415031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.78030838
2MP0003787_abnormal_imprinting3.05658627
3MP0003195_calcinosis2.95807374
4MP0002876_abnormal_thyroid_physiology2.91257339
5MP0005551_abnormal_eye_electrophysiolog2.59598514
6MP0002837_dystrophic_cardiac_calcinosis2.37665301
7MP0002102_abnormal_ear_morphology2.26326260
8MP0001968_abnormal_touch/_nociception2.22718286
9MP0009046_muscle_twitch2.18572261
10MP0002638_abnormal_pupillary_reflex2.17726732
11MP0006072_abnormal_retinal_apoptosis2.13186292
12MP0005253_abnormal_eye_physiology2.04007301
13MP0002163_abnormal_gland_morphology2.00986893
14MP0001984_abnormal_olfaction1.95971021
15MP0000372_irregular_coat_pigmentation1.95234547
16MP0002736_abnormal_nociception_after1.91457134
17MP0001986_abnormal_taste_sensitivity1.89403407
18MP0005645_abnormal_hypothalamus_physiol1.85144263
19MP0010386_abnormal_urinary_bladder1.84174004
20MP0005646_abnormal_pituitary_gland1.83264793
21MP0004043_abnormal_pH_regulation1.78481249
22MP0004147_increased_porphyrin_level1.74903101
23MP0001501_abnormal_sleep_pattern1.74302366
24MP0009745_abnormal_behavioral_response1.63325628
25MP0002272_abnormal_nervous_system1.61166559
26MP0005084_abnormal_gallbladder_morpholo1.60910154
27MP0008872_abnormal_physiological_respon1.60884027
28MP0005379_endocrine/exocrine_gland_phen1.58261770
29MP0000631_abnormal_neuroendocrine_gland1.58138018
30MP0003011_delayed_dark_adaptation1.57499249
31MP0003646_muscle_fatigue1.55834340
32MP0006292_abnormal_olfactory_placode1.55202635
33MP0004142_abnormal_muscle_tone1.53315581
34MP0001486_abnormal_startle_reflex1.52575890
35MP0004885_abnormal_endolymph1.52366503
36MP0003880_abnormal_central_pattern1.51665881
37MP0001764_abnormal_homeostasis1.43217523
38MP0004145_abnormal_muscle_electrophysio1.42200569
39MP0008058_abnormal_DNA_repair1.40855748
40MP0003786_premature_aging1.40517652
41MP0005075_abnormal_melanosome_morpholog1.40359054
42MP0000427_abnormal_hair_cycle1.38004854
43MP0001919_abnormal_reproductive_system1.34624019
44MP0002254_reproductive_system_inflammat1.34319717
45MP0003121_genomic_imprinting1.32815689
46MP0006276_abnormal_autonomic_nervous1.30835504
47MP0002693_abnormal_pancreas_physiology1.30600220
48MP0005389_reproductive_system_phenotype1.28785435
49MP0004019_abnormal_vitamin_homeostasis1.27542607
50MP0003186_abnormal_redox_activity1.26747111
51MP0004215_abnormal_myocardial_fiber1.24682284
52MP0006054_spinal_hemorrhage1.24482435
53MP0002938_white_spotting1.15261333
54MP0002138_abnormal_hepatobiliary_system1.14826151
55MP0008875_abnormal_xenobiotic_pharmacok1.12811371
56MP0004133_heterotaxia1.12082807
57MP0008995_early_reproductive_senescence1.11575606
58MP0003137_abnormal_impulse_conducting1.10636155
59MP0002572_abnormal_emotion/affect_behav1.10509271
60MP0003122_maternal_imprinting1.10395838
61MP0001970_abnormal_pain_threshold1.09594468
62MP0002229_neurodegeneration1.09575096
63MP0005332_abnormal_amino_acid1.09448166
64MP0001944_abnormal_pancreas_morphology1.09366980
65MP0005174_abnormal_tail_pigmentation1.09073238
66MP0001485_abnormal_pinna_reflex1.08564478
67MP0005386_behavior/neurological_phenoty1.08368168
68MP0004924_abnormal_behavior1.08368168
69MP0000538_abnormal_urinary_bladder1.08004581
70MP0002064_seizures1.07780312
71MP0002909_abnormal_adrenal_gland1.07692833
72MP0005310_abnormal_salivary_gland1.07690059
73MP0000569_abnormal_digit_pigmentation1.04736278
74MP0002234_abnormal_pharynx_morphology1.03911562
75MP0000613_abnormal_salivary_gland1.02037933
76MP0002557_abnormal_social/conspecific_i1.00257849
77MP0001529_abnormal_vocalization0.99250913
78MP0010329_abnormal_lipoprotein_level0.98581071
79MP0002160_abnormal_reproductive_system0.97509841
80MP0002735_abnormal_chemical_nociception0.97072895
81MP0001188_hyperpigmentation0.96812770
82MP0002734_abnormal_mechanical_nocicepti0.96776575
83MP0005085_abnormal_gallbladder_physiolo0.95250785
84MP0005195_abnormal_posterior_eye0.94531164
85MP0002733_abnormal_thermal_nociception0.93511603
86MP0002928_abnormal_bile_duct0.90865671
87MP0003718_maternal_effect0.90011211
88MP0005410_abnormal_fertilization0.89372381
89MP0000383_abnormal_hair_follicle0.88583391
90MP0002095_abnormal_skin_pigmentation0.85935080
91MP0002067_abnormal_sensory_capabilities0.84171943
92MP0005636_abnormal_mineral_homeostasis0.82272261
93MP0001502_abnormal_circadian_rhythm0.82015011
94MP0005220_abnormal_exocrine_pancreas0.82012353
95MP0005448_abnormal_energy_balance0.79428764
96MP0003698_abnormal_male_reproductive0.79387038
97MP0005167_abnormal_blood-brain_barrier0.79375851
98MP0002063_abnormal_learning/memory/cond0.78904639
99MP0001929_abnormal_gametogenesis0.78591626
100MP0001765_abnormal_ion_homeostasis0.77828932

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.12901186
2Congenital stationary night blindness (HP:0007642)4.01374410
3Pancreatic fibrosis (HP:0100732)3.59859974
4Abnormality of midbrain morphology (HP:0002418)3.47073107
5Molar tooth sign on MRI (HP:0002419)3.47073107
6Medial flaring of the eyebrow (HP:0010747)3.45299575
7True hermaphroditism (HP:0010459)3.39274577
8Nephronophthisis (HP:0000090)3.38494798
9Abnormality of the renal cortex (HP:0011035)3.22973020
10Chronic hepatic failure (HP:0100626)3.01058923
11Abnormality of the renal medulla (HP:0100957)2.97123458
12Progressive inability to walk (HP:0002505)2.94676058
13Abnormal drinking behavior (HP:0030082)2.93349490
14Polydipsia (HP:0001959)2.93349490
15Abnormal rod and cone electroretinograms (HP:0008323)2.92673758
16Hyperventilation (HP:0002883)2.85659824
17Type II lissencephaly (HP:0007260)2.85519758
18Tubular atrophy (HP:0000092)2.77112934
19Gaze-evoked nystagmus (HP:0000640)2.76846844
20Attenuation of retinal blood vessels (HP:0007843)2.72147121
21Large for gestational age (HP:0001520)2.69891884
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68999714
23Pendular nystagmus (HP:0012043)2.62817521
24Acute necrotizing encephalopathy (HP:0006965)2.54808990
25Gait imbalance (HP:0002141)2.41941075
26Congenital primary aphakia (HP:0007707)2.41859415
27Progressive macrocephaly (HP:0004481)2.40786933
28Hypothermia (HP:0002045)2.37817014
29Mitochondrial inheritance (HP:0001427)2.34733677
30Ketoacidosis (HP:0001993)2.34076609
31Abnormality of renal excretion (HP:0011036)2.33914509
32Abolished electroretinogram (ERG) (HP:0000550)2.32279309
33Cystic liver disease (HP:0006706)2.31595277
34Inability to walk (HP:0002540)2.29790432
35Nephrogenic diabetes insipidus (HP:0009806)2.29565443
36Polyuria (HP:0000103)2.29430275
37Keratoconus (HP:0000563)2.26105457
38Increased corneal curvature (HP:0100692)2.26105457
39Increased CSF lactate (HP:0002490)2.25400293
40Acute encephalopathy (HP:0006846)2.22071217
41Lissencephaly (HP:0001339)2.20218466
42Agitation (HP:0000713)2.19888750
43Decreased central vision (HP:0007663)2.18565450
44Aplasia/hypoplasia of the uterus (HP:0008684)2.16317296
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.14882532
46Hypoplasia of the fovea (HP:0007750)2.14882532
47Renal cortical cysts (HP:0000803)2.14528443
48Hypoplasia of the uterus (HP:0000013)2.12284869
49Abnormality of the pons (HP:0007361)2.11819152
50Ketosis (HP:0001946)2.11587758
51Abnormal mitochondria in muscle tissue (HP:0008316)2.11209945
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09626146
53Cerebellar dysplasia (HP:0007033)2.04335281
54Hypoplasia of the pons (HP:0012110)2.04216020
55Furrowed tongue (HP:0000221)2.04150838
56Volvulus (HP:0002580)2.03495141
57Congenital hepatic fibrosis (HP:0002612)2.03127321
58Broad-based gait (HP:0002136)2.02118432
59Intestinal atresia (HP:0011100)2.00493061
60Type 2 muscle fiber atrophy (HP:0003554)1.98119306
61Genetic anticipation (HP:0003743)1.96779806
62Abnormal protein glycosylation (HP:0012346)1.95247561
63Abnormal glycosylation (HP:0012345)1.95247561
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95247561
65Abnormal protein N-linked glycosylation (HP:0012347)1.95247561
66Abnormal urine output (HP:0012590)1.94011307
67Abnormal albumin level (HP:0012116)1.93427001
68Hypoalbuminemia (HP:0003073)1.93427001
69Hepatocellular necrosis (HP:0001404)1.92650974
70Abnormality of renal resorption (HP:0011038)1.92282561
71Hypoproteinemia (HP:0003075)1.91768005
72Constricted visual fields (HP:0001133)1.91200250
73Decreased circulating renin level (HP:0003351)1.90849547
74Pancreatic islet-cell hyperplasia (HP:0004510)1.90708655
75Genital tract atresia (HP:0001827)1.89403431
76Type I transferrin isoform profile (HP:0003642)1.88644879
77Colon cancer (HP:0003003)1.88264493
78Thyroiditis (HP:0100646)1.88169665
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.87169950
80Sclerocornea (HP:0000647)1.86984100
81Hemiparesis (HP:0001269)1.86539720
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84894776
83Abnormality of alanine metabolism (HP:0010916)1.84894776
84Hyperalaninemia (HP:0003348)1.84894776
85Abnormal biliary tract physiology (HP:0012439)1.83877773
86Bile duct proliferation (HP:0001408)1.83877773
87Abnormality of the fovea (HP:0000493)1.83571872
88Hepatic necrosis (HP:0002605)1.81705673
893-Methylglutaconic aciduria (HP:0003535)1.80394219
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.79869324
91Stomach cancer (HP:0012126)1.79726994
92Optic disc pallor (HP:0000543)1.79488363
93Disproportionate short-trunk short stature (HP:0003521)1.79314942
94Vaginal atresia (HP:0000148)1.78905121
95Dyskinesia (HP:0100660)1.77901658
96Hyperinsulinemic hypoglycemia (HP:0000825)1.76403062
97Polyphagia (HP:0002591)1.73658928
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.72946634
99Anencephaly (HP:0002323)1.72226067
100Progressive cerebellar ataxia (HP:0002073)1.71673245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.53683643
2ADRBK22.70017005
3MAP4K22.53833400
4WNK42.49624032
5WNK32.41920855
6CAMKK22.35246572
7GRK12.29325056
8BMPR1B2.25869638
9CASK2.15983092
10ACVR1B2.14293919
11ZAK1.96308570
12MAP3K41.93074073
13PINK11.91369973
14MAPK131.88141425
15MST41.82523500
16PIK3CA1.80784402
17STK391.77246348
18NUAK11.77230182
19OXSR11.73209089
20MAP2K71.64279858
21TRIM281.63438902
22DAPK21.54684645
23TXK1.54322461
24INSRR1.53113776
25EIF2AK31.52754227
26NTRK31.37756184
27TAOK31.36225744
28PIK3CG1.25538091
29NLK1.20142565
30TLK11.14321798
31MAPKAPK31.13272084
32PRKCE1.13253775
33AKT31.12940443
34CSNK1G11.12758640
35PAK31.10760643
36TNIK1.10610581
37MKNK21.10504126
38PLK21.07654066
39BCKDK1.01565373
40MUSK1.01117686
41PHKG11.01113696
42PHKG21.01113696
43FGFR20.99060830
44BRSK20.96087171
45STK38L0.95715898
46ADRBK10.88404592
47PRKCG0.87865219
48FER0.87272920
49TIE10.86642459
50CAMK1D0.84909497
51BCR0.83472345
52CSNK1G20.83310792
53CSNK1G30.82062772
54CAMK10.76559470
55EPHA30.76541516
56ERBB30.74918619
57PTK2B0.72931234
58CSNK1A1L0.72294938
59MAP2K60.70224754
60DYRK20.69489921
61TEC0.67035005
62CAMK1G0.66704021
63PLK40.64418237
64MARK10.58370635
65IKBKB0.57693209
66CSNK1A10.56390866
67ITK0.55750848
68CAMK2A0.52306766
69IRAK10.52169381
70VRK10.49503890
71EPHA40.48589968
72PLK30.48506386
73PRKACA0.47235379
74CDK30.45828856
75EIF2AK10.45788845
76RPS6KA50.45012947
77TSSK60.45001149
78SGK20.44111757
79NTRK20.42747379
80CAMK2D0.42701470
81STK110.42456673
82CAMK40.41653754
83CAMKK10.41148736
84TNK20.40646350
85PRKAA10.39299340
86PRKCQ0.39097055
87STK160.38151372
88GRK70.37575359
89PRKCI0.36442969
90CSNK1D0.36366928
91PLK10.35492562
92SGK2230.35144104
93SGK4940.35144104
94PRKCA0.35106065
95PRKAA20.33484489
96OBSCN0.32727304
97IGF1R0.32172033
98MKNK10.31722931
99PRKG10.31154713
100PDK20.30261263

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.75473210
2Phototransduction_Homo sapiens_hsa047442.72875927
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47099168
4Butanoate metabolism_Homo sapiens_hsa006502.41930988
5Selenocompound metabolism_Homo sapiens_hsa004502.34754502
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.34726847
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31667173
8Linoleic acid metabolism_Homo sapiens_hsa005912.23276985
9Protein export_Homo sapiens_hsa030602.19537430
10Oxidative phosphorylation_Homo sapiens_hsa001902.18767001
11Nitrogen metabolism_Homo sapiens_hsa009102.17717275
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09086150
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02668921
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98273231
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94083314
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94078745
17Ether lipid metabolism_Homo sapiens_hsa005651.93860636
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57988609
19Basal transcription factors_Homo sapiens_hsa030221.50867019
20Homologous recombination_Homo sapiens_hsa034401.50803334
21Nicotine addiction_Homo sapiens_hsa050331.48637422
22Propanoate metabolism_Homo sapiens_hsa006401.47415377
23Tryptophan metabolism_Homo sapiens_hsa003801.47166389
24RNA polymerase_Homo sapiens_hsa030201.44556547
25Parkinsons disease_Homo sapiens_hsa050121.43688570
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38251401
27Insulin secretion_Homo sapiens_hsa049111.37784670
28Caffeine metabolism_Homo sapiens_hsa002321.37083141
29RNA degradation_Homo sapiens_hsa030181.36398529
30Sulfur metabolism_Homo sapiens_hsa009201.33320940
31Fanconi anemia pathway_Homo sapiens_hsa034601.32231091
32Collecting duct acid secretion_Homo sapiens_hsa049661.31775043
33Peroxisome_Homo sapiens_hsa041461.30402228
34Proteasome_Homo sapiens_hsa030501.28237812
35ABC transporters_Homo sapiens_hsa020101.27457797
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20196189
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17628824
38Olfactory transduction_Homo sapiens_hsa047401.14359470
39Regulation of autophagy_Homo sapiens_hsa041401.13056185
40Taste transduction_Homo sapiens_hsa047421.12979105
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11904725
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10776295
43Non-homologous end-joining_Homo sapiens_hsa034501.08653676
44Huntingtons disease_Homo sapiens_hsa050161.03234505
45Arachidonic acid metabolism_Homo sapiens_hsa005901.02236985
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98983260
47Alzheimers disease_Homo sapiens_hsa050100.93817567
48beta-Alanine metabolism_Homo sapiens_hsa004100.93292823
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89688144
50One carbon pool by folate_Homo sapiens_hsa006700.89408554
51Chemical carcinogenesis_Homo sapiens_hsa052040.87542618
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85687346
53Retinol metabolism_Homo sapiens_hsa008300.85550672
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.83111261
55Type I diabetes mellitus_Homo sapiens_hsa049400.81836020
56Circadian rhythm_Homo sapiens_hsa047100.81477474
57Morphine addiction_Homo sapiens_hsa050320.80097228
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.79896322
59GABAergic synapse_Homo sapiens_hsa047270.77337538
60Metabolic pathways_Homo sapiens_hsa011000.76669588
61Cardiac muscle contraction_Homo sapiens_hsa042600.74971905
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74712072
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74506806
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73785134
65Fatty acid elongation_Homo sapiens_hsa000620.71708577
66Fat digestion and absorption_Homo sapiens_hsa049750.71153076
67Circadian entrainment_Homo sapiens_hsa047130.70358425
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69381612
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68484093
70Sphingolipid metabolism_Homo sapiens_hsa006000.66909586
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.66772952
72Synaptic vesicle cycle_Homo sapiens_hsa047210.64748437
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63685201
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62661123
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62001157
76Mineral absorption_Homo sapiens_hsa049780.61940641
77Purine metabolism_Homo sapiens_hsa002300.61340266
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61263099
79Serotonergic synapse_Homo sapiens_hsa047260.61153215
80Glutamatergic synapse_Homo sapiens_hsa047240.60751968
81Calcium signaling pathway_Homo sapiens_hsa040200.59944269
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59621255
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.58234051
84Histidine metabolism_Homo sapiens_hsa003400.57555697
85Fatty acid degradation_Homo sapiens_hsa000710.55958884
86Amphetamine addiction_Homo sapiens_hsa050310.53514357
87Steroid biosynthesis_Homo sapiens_hsa001000.52193075
88Salivary secretion_Homo sapiens_hsa049700.52169047
89Pyrimidine metabolism_Homo sapiens_hsa002400.50285308
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50099954
91Vitamin digestion and absorption_Homo sapiens_hsa049770.49676578
92Ovarian steroidogenesis_Homo sapiens_hsa049130.49061133
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.48166584
94Glycerolipid metabolism_Homo sapiens_hsa005610.47267109
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44780043
96Dopaminergic synapse_Homo sapiens_hsa047280.44499249
97Fatty acid metabolism_Homo sapiens_hsa012120.43764756
98Primary immunodeficiency_Homo sapiens_hsa053400.40866806
99Arginine and proline metabolism_Homo sapiens_hsa003300.40851647
100Asthma_Homo sapiens_hsa053100.37298212

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