PBRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.32578087
2mitotic sister chromatid cohesion (GO:0007064)5.29972591
3DNA topological change (GO:0006265)4.88081300
4pyrimidine nucleobase catabolic process (GO:0006208)4.60067825
5histone H3-K4 trimethylation (GO:0080182)4.42744349
6regulation of DNA endoreduplication (GO:0032875)4.34872521
7kinetochore organization (GO:0051383)4.23500438
8nuclear pore complex assembly (GO:0051292)4.10797323
9nuclear pore organization (GO:0006999)3.72610474
10cerebral cortex radially oriented cell migration (GO:0021799)3.65590942
11DNA unwinding involved in DNA replication (GO:0006268)3.61049296
12microtubule anchoring (GO:0034453)3.60188856
13peptidyl-lysine trimethylation (GO:0018023)3.52831235
14artery development (GO:0060840)3.46839294
15presynaptic membrane assembly (GO:0097105)3.43332577
16nucleobase catabolic process (GO:0046113)3.30703254
17central nervous system projection neuron axonogenesis (GO:0021952)3.29117922
18olfactory bulb development (GO:0021772)3.25283713
19kinetochore assembly (GO:0051382)3.24572387
20sister chromatid segregation (GO:0000819)3.22795789
21nucleus localization (GO:0051647)3.21950048
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.21871296
23mitotic chromosome condensation (GO:0007076)3.18807036
24forebrain neuron differentiation (GO:0021879)3.18127557
25DNA ligation (GO:0006266)3.15026211
26protein localization to microtubule cytoskeleton (GO:0072698)3.14391501
27cytoplasmic mRNA processing body assembly (GO:0033962)3.07552048
28regulation of meiosis I (GO:0060631)3.03082164
29establishment of nucleus localization (GO:0040023)3.02739595
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.02102168
31pore complex assembly (GO:0046931)3.01908433
32negative regulation of fibroblast apoptotic process (GO:2000270)3.00480398
33monoubiquitinated protein deubiquitination (GO:0035520)2.96942430
34presynaptic membrane organization (GO:0097090)2.96104509
35interkinetic nuclear migration (GO:0022027)2.94552631
36central nervous system neuron axonogenesis (GO:0021955)2.94408026
37dosage compensation (GO:0007549)2.93111813
38microtubule depolymerization (GO:0007019)2.89631393
39protein localization to kinetochore (GO:0034501)2.84508605
40mitotic recombination (GO:0006312)2.84344882
41histone H3-K4 methylation (GO:0051568)2.82288567
42regulation of histone H3-K9 methylation (GO:0051570)2.80959788
43positive regulation of cell cycle checkpoint (GO:1901978)2.80342322
44meiotic chromosome segregation (GO:0045132)2.79004387
45positive regulation of histone H3-K4 methylation (GO:0051571)2.78463258
46CENP-A containing nucleosome assembly (GO:0034080)2.77969827
47chromatin remodeling at centromere (GO:0031055)2.77876928
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76326304
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76326304
50positive regulation of mitotic sister chromatid separation (GO:1901970)2.76326304
51peptidyl-lysine methylation (GO:0018022)2.75631767
52DNA replication-independent nucleosome assembly (GO:0006336)2.75556369
53DNA replication-independent nucleosome organization (GO:0034724)2.75556369
54V(D)J recombination (GO:0033151)2.74754536
55sister chromatid cohesion (GO:0007062)2.74720858
56replication fork processing (GO:0031297)2.74167842
57ATP-dependent chromatin remodeling (GO:0043044)2.73435058
58histone lysine methylation (GO:0034968)2.72778192
59definitive hemopoiesis (GO:0060216)2.71389434
60pre-miRNA processing (GO:0031054)2.70931356
61cell proliferation in forebrain (GO:0021846)2.70254523
62regulation of telomere maintenance (GO:0032204)2.70114585
63renal system development (GO:0072001)2.69098053
64head development (GO:0060322)2.68334456
65regulation of sister chromatid cohesion (GO:0007063)2.66967219
66negative regulation of histone methylation (GO:0031061)2.65491641
67regulation of RNA export from nucleus (GO:0046831)2.65092301
68microtubule organizing center organization (GO:0031023)2.64436231
69retinal ganglion cell axon guidance (GO:0031290)2.63880208
70cerebral cortex cell migration (GO:0021795)2.60351340
71gastrulation with mouth forming second (GO:0001702)2.60242137
72DNA double-strand break processing (GO:0000729)2.59776640
73protein localization to cytoskeleton (GO:0044380)2.59397573
74positive regulation of developmental pigmentation (GO:0048087)2.59390577
75regulation of double-strand break repair via homologous recombination (GO:0010569)2.58749566
76behavioral response to nicotine (GO:0035095)2.58722471
77non-recombinational repair (GO:0000726)2.57611965
78double-strand break repair via nonhomologous end joining (GO:0006303)2.57611965
79metaphase plate congression (GO:0051310)2.57041689
80neuron recognition (GO:0008038)2.56889467
81regulation of DNA damage checkpoint (GO:2000001)2.56179504
82DNA duplex unwinding (GO:0032508)2.54977317
83spindle checkpoint (GO:0031577)2.54823115
84axonal fasciculation (GO:0007413)2.54573592
85limb bud formation (GO:0060174)2.54336034
86DNA geometric change (GO:0032392)2.53491649
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53121369
88myelin assembly (GO:0032288)2.52140346
89centrosome duplication (GO:0051298)2.51412895
90postsynaptic membrane organization (GO:0001941)2.50337181
91mitotic sister chromatid segregation (GO:0000070)2.50040436
92protein localization to chromosome, centromeric region (GO:0071459)2.49356270
93neural tube formation (GO:0001841)2.48642333
94microtubule nucleation (GO:0007020)2.48189705
95dorsal/ventral axis specification (GO:0009950)2.47390994
96regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46608796
97regulation of mitotic spindle checkpoint (GO:1903504)2.46608796
98positive regulation of DNA-templated transcription, initiation (GO:2000144)2.46399943
99spinal cord development (GO:0021510)2.46157664
100intra-S DNA damage checkpoint (GO:0031573)2.46036926
101negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.44995457
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.44995457
103regulation of translation, ncRNA-mediated (GO:0045974)2.44995457
104alternative mRNA splicing, via spliceosome (GO:0000380)2.44962977
105mRNA splice site selection (GO:0006376)2.44788336
106response to X-ray (GO:0010165)2.44491173
107spliceosomal complex assembly (GO:0000245)2.44271209
108ganglion development (GO:0061548)2.43567060
109attachment of spindle microtubules to kinetochore (GO:0008608)2.42875782
110histone H3-K9 methylation (GO:0051567)2.42850173
111sympathetic nervous system development (GO:0048485)2.41771589
112regulation of histone H3-K4 methylation (GO:0051569)2.41477946
113regulation of double-strand break repair (GO:2000779)2.40048779
114telomere maintenance via recombination (GO:0000722)2.39858804
115DNA strand renaturation (GO:0000733)2.39806441
116histone H3-K9 modification (GO:0061647)2.39722057
117negative regulation of DNA repair (GO:0045738)2.39645979
118double-strand break repair via homologous recombination (GO:0000724)2.39469142
119regulation of mitotic metaphase/anaphase transition (GO:0030071)2.39349307
120DNA conformation change (GO:0071103)2.39093171
121spindle assembly checkpoint (GO:0071173)2.37838469
122recombinational repair (GO:0000725)2.37693934
123protein localization to chromosome (GO:0034502)2.37684842
124mitotic metaphase plate congression (GO:0007080)2.37271658
125regulation of pigment cell differentiation (GO:0050932)2.37120872
126limb development (GO:0060173)2.37002477
127appendage development (GO:0048736)2.37002477
128regulation of centriole replication (GO:0046599)2.36918240
129negative regulation of RNA splicing (GO:0033119)2.35852093
130hippo signaling (GO:0035329)2.35792772
131establishment of chromosome localization (GO:0051303)2.35525262
132neuronal stem cell maintenance (GO:0097150)2.35438681
133protein-DNA complex disassembly (GO:0032986)2.34015367
134nucleosome disassembly (GO:0006337)2.34015367
135chromatin assembly (GO:0031497)2.34003072
136centrosome organization (GO:0051297)2.32202240
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.31623951
138regulation of mitotic sister chromatid separation (GO:0010965)2.31607886
139regulation of mitotic sister chromatid segregation (GO:0033047)2.31607886
140regulation of sister chromatid segregation (GO:0033045)2.31607886
141chromatin assembly or disassembly (GO:0006333)2.31590184
142acrosome assembly (GO:0001675)2.30918571
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30766236
144glucocorticoid receptor signaling pathway (GO:0042921)2.30692675
145RNA stabilization (GO:0043489)2.30317514
146mRNA stabilization (GO:0048255)2.30317514
147mitotic spindle checkpoint (GO:0071174)2.30214881
148histone mRNA catabolic process (GO:0071044)2.29656225
149kidney morphogenesis (GO:0060993)2.29302221
150translesion synthesis (GO:0019985)2.28680192
151centriole replication (GO:0007099)2.28633748
152histone H2A acetylation (GO:0043968)2.27324910
153inner ear receptor cell development (GO:0060119)2.27320178
154regulation of DNA-templated transcription, initiation (GO:2000142)2.26471488
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.25692528
156regulation of centrosome duplication (GO:0010824)2.25460152
157positive regulation of chromosome segregation (GO:0051984)2.25441956
158telomere maintenance via semi-conservative replication (GO:0032201)2.25371448
159nucleotide-excision repair, DNA gap filling (GO:0006297)2.23951912
160regulation of histone methylation (GO:0031060)2.23773440
161metanephric mesenchyme development (GO:0072075)2.23610317
162DNA strand elongation involved in DNA replication (GO:0006271)2.22793454
163histone exchange (GO:0043486)2.22623416
164mitotic spindle assembly checkpoint (GO:0007094)2.21720096
165chromosome segregation (GO:0007059)2.21179609
166negative regulation of mitotic sister chromatid separation (GO:2000816)2.20501265
167negative regulation of mitotic sister chromatid segregation (GO:0033048)2.20501265
168negative regulation of sister chromatid segregation (GO:0033046)2.20501265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.09652203
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.01758451
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.54478701
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36290327
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16946795
6RBPJ_22232070_ChIP-Seq_NCS_Mouse4.12004196
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.09711355
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99943324
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94503580
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.92691879
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.79012096
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.70243234
13GBX2_23144817_ChIP-Seq_PC3_Human2.69699537
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.62435221
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.25968221
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.18063240
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.16818512
18ELK1_19687146_ChIP-ChIP_HELA_Human2.10232324
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03937842
20EWS_26573619_Chip-Seq_HEK293_Human2.03903935
21VDR_22108803_ChIP-Seq_LS180_Human1.99511157
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95922036
23ZNF274_21170338_ChIP-Seq_K562_Hela1.93323969
24AR_21572438_ChIP-Seq_LNCaP_Human1.89199048
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87120516
26FUS_26573619_Chip-Seq_HEK293_Human1.86948372
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.81377042
28SMAD4_21799915_ChIP-Seq_A2780_Human1.80958532
29EZH2_22144423_ChIP-Seq_EOC_Human1.74869634
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69356512
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63439655
32STAT3_23295773_ChIP-Seq_U87_Human1.61590023
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61480862
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.58767758
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58638771
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58226299
37AR_21909140_ChIP-Seq_LNCAP_Human1.56334976
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.54414832
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54239578
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49124403
41* TCF4_23295773_ChIP-Seq_U87_Human1.48271354
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43567042
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43567042
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42731253
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40745195
46FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39360665
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39284361
48* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38266527
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35336838
50* CBP_20019798_ChIP-Seq_JUKART_Human1.35014717
51* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35014717
52ER_23166858_ChIP-Seq_MCF-7_Human1.34397316
53AR_25329375_ChIP-Seq_VCAP_Human1.33689247
54* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30749735
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28808493
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27705504
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27588076
58BRD4_25478319_ChIP-Seq_HGPS_Human1.25522128
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25339113
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25169100
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24572242
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.23743173
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23491141
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.21883596
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21261564
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20413739
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20314648
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17933539
69P53_22387025_ChIP-Seq_ESCs_Mouse1.17193765
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16718796
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16239814
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14806281
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12688118
74CIITA_25753668_ChIP-Seq_RAJI_Human1.12614324
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.12396817
76IRF1_19129219_ChIP-ChIP_H3396_Human1.11810662
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10852903
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10645138
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10189593
80RUNX2_22187159_ChIP-Seq_PCA_Human1.09759578
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09283966
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09246980
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09222072
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.08858158
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08098284
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08000514
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.07863741
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07659382
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07472295
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07310143
91JUN_21703547_ChIP-Seq_K562_Human1.07095436
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07091994
93BCAT_22108803_ChIP-Seq_LS180_Human1.06757692
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05932633
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03503493
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02771437
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02487932
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01948013
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01560094
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01506342
101CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01292959
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.00965392
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00246095
104RXR_22108803_ChIP-Seq_LS180_Human1.00199713
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.99711024
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.99291417
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98417820
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98145418
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97559729
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97248570
111IGF1R_20145208_ChIP-Seq_DFB_Human0.97054559
112TP53_16413492_ChIP-PET_HCT116_Human0.95928385
113MYC_18555785_ChIP-Seq_MESCs_Mouse0.94005356
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.91792646
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89397923
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89397923
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88668164
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88426724
119TP53_18474530_ChIP-ChIP_U2OS_Human0.88000305
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87480800
121* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85846438
122BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85698741
123P300_19829295_ChIP-Seq_ESCs_Human0.85053164
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83397254
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83152649
126SOX9_26525672_Chip-Seq_HEART_Mouse0.82664843
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80901135
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.78830739
129TAF15_26573619_Chip-Seq_HEK293_Human0.78316847
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77818868
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77368879
132MYC_18940864_ChIP-ChIP_HL60_Human0.76941179
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.76210932
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.75976536
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75304499
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74978224
137VDR_23849224_ChIP-Seq_CD4+_Human0.74674975
138RNF2_27304074_Chip-Seq_NSC_Mouse0.74474133
139EST1_17652178_ChIP-ChIP_JURKAT_Human0.74427060
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.74372916
141CHD1_26751641_Chip-Seq_LNCaP_Human0.73782290
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73635629
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.72773453
144* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72540591
145MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.72526848
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.72148468
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.71728376
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71264901
149* TTF2_22483619_ChIP-Seq_HELA_Human0.70972372
150AHR_22903824_ChIP-Seq_MCF-7_Human0.70910570
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.70479062
152GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70453874
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.70434040
154GF1B_26923725_Chip-Seq_HPCs_Mouse0.69827808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.15826808
2MP0000569_abnormal_digit_pigmentation2.60035982
3MP0003121_genomic_imprinting2.57613287
4MP0000566_synostosis2.47951431
5MP0003941_abnormal_skin_development2.47811668
6MP0010094_abnormal_chromosome_stability2.30735852
7MP0003787_abnormal_imprinting2.24371049
8MP0000778_abnormal_nervous_system2.24057303
9MP0002938_white_spotting2.12778281
10MP0003123_paternal_imprinting2.10205923
11MP0002009_preneoplasia2.07422806
12MP0005187_abnormal_penis_morphology2.06674129
13MP0006054_spinal_hemorrhage1.93505770
14MP0003937_abnormal_limbs/digits/tail_de1.82972683
15MP0003385_abnormal_body_wall1.78288574
16MP0003077_abnormal_cell_cycle1.76309832
17MP0003111_abnormal_nucleus_morphology1.74631873
18MP0003122_maternal_imprinting1.74094457
19MP0003890_abnormal_embryonic-extraembry1.73961484
20MP0000537_abnormal_urethra_morphology1.72287363
21MP0008007_abnormal_cellular_replicative1.64312174
22MP0003567_abnormal_fetal_cardiomyocyte1.60677241
23MP0010352_gastrointestinal_tract_polyps1.60365952
24MP0006276_abnormal_autonomic_nervous1.58561017
25MP0002822_catalepsy1.56898076
26MP0005076_abnormal_cell_differentiation1.52332351
27MP0004742_abnormal_vestibular_system1.52069832
28MP0002102_abnormal_ear_morphology1.50617655
29MP0000383_abnormal_hair_follicle1.45311294
30MP0003693_abnormal_embryo_hatching1.44265189
31MP0008058_abnormal_DNA_repair1.42400815
32MP0008877_abnormal_DNA_methylation1.41928018
33MP0009250_abnormal_appendicular_skeleto1.41193453
34MP0002877_abnormal_melanocyte_morpholog1.37977738
35MP0008932_abnormal_embryonic_tissue1.37956674
36MP0003861_abnormal_nervous_system1.37706567
37MP0003935_abnormal_craniofacial_develop1.36442349
38MP0010030_abnormal_orbit_morphology1.35064716
39MP0000049_abnormal_middle_ear1.34394658
40MP0003942_abnormal_urinary_system1.32671371
41MP0004957_abnormal_blastocyst_morpholog1.32069025
42MP0002396_abnormal_hematopoietic_system1.31344552
43MP0003755_abnormal_palate_morphology1.29208150
44MP0005503_abnormal_tendon_morphology1.28333497
45MP0006072_abnormal_retinal_apoptosis1.27732764
46MP0004197_abnormal_fetal_growth/weight/1.27497222
47MP0005409_darkened_coat_color1.27139044
48MP0010307_abnormal_tumor_latency1.24771467
49MP0010678_abnormal_skin_adnexa1.24678912
50MP0001485_abnormal_pinna_reflex1.24289666
51MP0009053_abnormal_anal_canal1.24243418
52MP0005367_renal/urinary_system_phenotyp1.23360893
53MP0000516_abnormal_urinary_system1.23360893
54MP0000428_abnormal_craniofacial_morphol1.22835592
55MP0004134_abnormal_chest_morphology1.22456124
56MP0004808_abnormal_hematopoietic_stem1.22047710
57MP0001879_abnormal_lymphatic_vessel1.21003428
58MP0000427_abnormal_hair_cycle1.20184959
59MP0000955_abnormal_spinal_cord1.19932966
60MP0000432_abnormal_head_morphology1.16866703
61MP0009703_decreased_birth_body1.16605435
62MP0002234_abnormal_pharynx_morphology1.16197094
63MP0009379_abnormal_foot_pigmentation1.15533986
64MP0000647_abnormal_sebaceous_gland1.13659238
65MP0002184_abnormal_innervation1.13042220
66MP0002177_abnormal_outer_ear1.12921644
67MP0002751_abnormal_autonomic_nervous1.11971683
68MP0001286_abnormal_eye_development1.11884019
69MP0002163_abnormal_gland_morphology1.11492705
70MP0003950_abnormal_plasma_membrane1.11073478
71MP0001293_anophthalmia1.10989497
72MP0002084_abnormal_developmental_patter1.08816471
73MP0002166_altered_tumor_susceptibility1.08261308
74MP0005174_abnormal_tail_pigmentation1.07462183
75MP0000350_abnormal_cell_proliferation1.07094586
76MP0005253_abnormal_eye_physiology1.06877014
77MP0002085_abnormal_embryonic_tissue1.06055428
78MP0002098_abnormal_vibrissa_morphology1.05562161
79MP0002735_abnormal_chemical_nociception1.05548179
80MP0006292_abnormal_olfactory_placode1.05367024
81MP0008789_abnormal_olfactory_epithelium1.04433843
82MP0009697_abnormal_copulation1.04091735
83MP0002095_abnormal_skin_pigmentation1.03420355
84MP0002697_abnormal_eye_size1.03360432
85MP0001188_hyperpigmentation1.02329640
86MP0004272_abnormal_basement_membrane1.02176555
87MP0005380_embryogenesis_phenotype1.01797891
88MP0001672_abnormal_embryogenesis/_devel1.01797891
89MP0005248_abnormal_Harderian_gland1.01514504
90MP0002109_abnormal_limb_morphology1.01474601
91MP0002006_tumorigenesis1.00848046
92MP0002116_abnormal_craniofacial_bone1.00249758
93MP0003115_abnormal_respiratory_system0.99968185
94MP0002088_abnormal_embryonic_growth/wei0.99204091
95MP0002081_perinatal_lethality0.98841264
96MP0005499_abnormal_olfactory_system0.98160632
97MP0005394_taste/olfaction_phenotype0.98160632
98MP0003984_embryonic_growth_retardation0.98076995
99MP0005171_absent_coat_pigmentation0.97861658
100MP0005391_vision/eye_phenotype0.97171363
101MP0000733_abnormal_muscle_development0.96826985
102MP0003763_abnormal_thymus_physiology0.95563846
103MP0005195_abnormal_posterior_eye0.95463431
104MP0008995_early_reproductive_senescence0.95439254
105MP0001697_abnormal_embryo_size0.95335640
106MP0002152_abnormal_brain_morphology0.94989076
107MP0002233_abnormal_nose_morphology0.94700914
108MP0003943_abnormal_hepatobiliary_system0.93734753
109MP0000534_abnormal_ureter_morphology0.92682994
110MP0004924_abnormal_behavior0.92087846
111MP0005386_behavior/neurological_phenoty0.92087846
112MP0002925_abnormal_cardiovascular_devel0.90886758
113MP0001346_abnormal_lacrimal_gland0.89969628
114MP0003136_yellow_coat_color0.89672522
115MP0001324_abnormal_eye_pigmentation0.89626268
116MP0002752_abnormal_somatic_nervous0.88656274
117* MP0002086_abnormal_extraembryonic_tissu0.87791043
118MP0002932_abnormal_joint_morphology0.87131050
119MP0000490_abnormal_crypts_of0.86532849
120MP0004145_abnormal_muscle_electrophysio0.86507654
121MP0002092_abnormal_eye_morphology0.85589863
122MP0001730_embryonic_growth_arrest0.85502881
123MP0002638_abnormal_pupillary_reflex0.85456377
124MP0009672_abnormal_birth_weight0.85337718
125MP0002882_abnormal_neuron_morphology0.84971119
126MP0000631_abnormal_neuroendocrine_gland0.84135121
127MP0000015_abnormal_ear_pigmentation0.82464026
128MP0004142_abnormal_muscle_tone0.82383071
129MP0004811_abnormal_neuron_physiology0.82008623
130MP0004885_abnormal_endolymph0.81114647
131MP0003119_abnormal_digestive_system0.80044542
132MP0004043_abnormal_pH_regulation0.79786813
133MP0002114_abnormal_axial_skeleton0.79378744
134MP0008438_abnormal_cutaneous_collagen0.78180274
135MP0001984_abnormal_olfaction0.77984986
136MP0001299_abnormal_eye_distance/0.77852089
137MP0000703_abnormal_thymus_morphology0.77495031
138MP0005623_abnormal_meninges_morphology0.76636088
139MP0003315_abnormal_perineum_morphology0.76535686
140MP0000372_irregular_coat_pigmentation0.76218398
141MP0004270_analgesia0.76083354

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.09230791
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.84425157
3Short 4th metacarpal (HP:0010044)3.84425157
4Abnormality of the labia minora (HP:0012880)3.55973692
5Lip pit (HP:0100267)3.13923867
6Abnormality of the fingertips (HP:0001211)3.10218319
7Cortical dysplasia (HP:0002539)2.99995507
8Abnormality of the nasal septum (HP:0000419)2.83342839
9Hyperventilation (HP:0002883)2.75113372
10Ectopic kidney (HP:0000086)2.73272607
11Birth length less than 3rd percentile (HP:0003561)2.72460141
12Deep philtrum (HP:0002002)2.68692662
13Chromsome breakage (HP:0040012)2.55928162
14Abnormality of the 4th metacarpal (HP:0010012)2.54731944
15Spinal cord lesions (HP:0100561)2.50120575
16Syringomyelia (HP:0003396)2.50120575
17Gastrointestinal atresia (HP:0002589)2.46296483
18Nephroblastoma (Wilms tumor) (HP:0002667)2.46023036
19Drooling (HP:0002307)2.44697520
20Asymmetry of the thorax (HP:0001555)2.42024788
21Patellar aplasia (HP:0006443)2.39106162
22Protruding tongue (HP:0010808)2.39088157
23Morphological abnormality of the middle ear (HP:0008609)2.36544952
24Acute lymphatic leukemia (HP:0006721)2.35854914
25Shawl scrotum (HP:0000049)2.34709054
26Embryonal renal neoplasm (HP:0011794)2.33210191
2711 pairs of ribs (HP:0000878)2.33034074
28Long eyelashes (HP:0000527)2.32164315
29Abnormality of the incisor (HP:0000676)2.29317168
30Colon cancer (HP:0003003)2.28640063
31Oligodactyly (hands) (HP:0001180)2.28105863
32Abnormality of incisor morphology (HP:0011063)2.27296155
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18821641
34Abnormality of the ischium (HP:0003174)2.17159986
35Excessive salivation (HP:0003781)2.16312264
36Midline defect of the nose (HP:0004122)2.16263869
37Progressive cerebellar ataxia (HP:0002073)2.14739089
38Oligodactyly (HP:0012165)2.13546292
39Abnormal lung lobation (HP:0002101)2.12489285
40Abnormality of chromosome stability (HP:0003220)2.12292307
41Papillary thyroid carcinoma (HP:0002895)2.12132804
42Hypoplastic ischia (HP:0003175)2.10904719
43Chronic hepatic failure (HP:0100626)2.10527201
44Cystic hygroma (HP:0000476)2.09328021
45Abnormal number of incisors (HP:0011064)2.08468111
46Deviation of the thumb (HP:0009603)2.07854151
47Aplasia/Hypoplasia of the patella (HP:0006498)2.06826171
48Subacute progressive viral hepatitis (HP:0006572)2.05022480
49Small hand (HP:0200055)2.03548526
50Heterotopia (HP:0002282)2.01267312
51High anterior hairline (HP:0009890)2.01195810
52Increased nuchal translucency (HP:0010880)1.99200810
53Hypoplastic labia majora (HP:0000059)1.97116005
54Proximal placement of thumb (HP:0009623)1.96351547
55Increased number of teeth (HP:0011069)1.93368664
56Abnormality of the aortic arch (HP:0012303)1.93090618
57Abnormality of the parietal bone (HP:0002696)1.90847574
58Hypoplastic iliac wings (HP:0002866)1.90344966
59Submucous cleft hard palate (HP:0000176)1.89675663
60Medulloblastoma (HP:0002885)1.89056200
61Hepatoblastoma (HP:0002884)1.88839826
62Abnormality of the nasolacrimal system (HP:0000614)1.87002195
63Long clavicles (HP:0000890)1.86987786
64Abnormality of the renal collecting system (HP:0004742)1.86098731
65Broad-based gait (HP:0002136)1.85976169
66Mesomelia (HP:0003027)1.85369255
67Cutaneous finger syndactyly (HP:0010554)1.84862857
68Labial hypoplasia (HP:0000066)1.83596842
69Rectal prolapse (HP:0002035)1.82820627
70Absent frontal sinuses (HP:0002688)1.82762411
71Esophageal atresia (HP:0002032)1.82710925
72Absent eyebrow (HP:0002223)1.82142600
73Cystic liver disease (HP:0006706)1.81810986
74Abnormality of the labia majora (HP:0012881)1.81247195
75Partial agenesis of the corpus callosum (HP:0001338)1.79455265
76Vertebral arch anomaly (HP:0008438)1.78231159
77Renal duplication (HP:0000075)1.78024327
78Cutaneous syndactyly (HP:0012725)1.77532632
79Abnormality of the intervertebral disk (HP:0005108)1.77252502
80Supernumerary ribs (HP:0005815)1.75870181
81Meckel diverticulum (HP:0002245)1.75587700
82Abnormality of the pubic bones (HP:0003172)1.75222769
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.74950694
84Micropenis (HP:0000054)1.74801817
85Facial hemangioma (HP:0000329)1.73658462
86Tented upper lip vermilion (HP:0010804)1.73034466
87Highly arched eyebrow (HP:0002553)1.72821181
88Cutis marmorata (HP:0000965)1.72337283
89Abnormality of the ileum (HP:0001549)1.70898332
90Optic nerve hypoplasia (HP:0000609)1.69920045
91Renal hypoplasia (HP:0000089)1.69624801
92Short middle phalanx of the 5th finger (HP:0004220)1.69510793
93Abnormality of the duodenum (HP:0002246)1.69181773
94Skull defect (HP:0001362)1.68939968
95Neoplasm of the oral cavity (HP:0100649)1.68398921
96Gastroesophageal reflux (HP:0002020)1.67107857
97Transitional cell carcinoma of the bladder (HP:0006740)1.67011870
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.66788330
99Genetic anticipation (HP:0003743)1.66775442
100Hypoplasia of the maxilla (HP:0000327)1.66702859
101Truncal obesity (HP:0001956)1.66462823
102Hypoplastic female external genitalia (HP:0012815)1.66365296
103Lissencephaly (HP:0001339)1.66232122
104Large earlobe (HP:0009748)1.66073269
105Neonatal hypoglycemia (HP:0001998)1.65915139
106Pancreatic fibrosis (HP:0100732)1.65469030
107Abnormality of the antihelix (HP:0009738)1.65409806
108Abnormality of chromosome segregation (HP:0002916)1.64950523
109Abnormality of the lacrimal duct (HP:0011481)1.63932133
110Back pain (HP:0003418)1.63753102
111Nephronophthisis (HP:0000090)1.63499552
112Thick eyebrow (HP:0000574)1.63251296
113Intestinal atresia (HP:0011100)1.62802243
114Narrow forehead (HP:0000341)1.62661997
115Acute myeloid leukemia (HP:0004808)1.62280735
116Malignant gastrointestinal tract tumors (HP:0006749)1.62164377
117Gastrointestinal carcinoma (HP:0002672)1.62164377
118Prominent nose (HP:0000448)1.62121008
119Pachygyria (HP:0001302)1.61927213
120Neoplasm of the adrenal cortex (HP:0100641)1.61478800
121Abnormality of the carotid arteries (HP:0005344)1.60703099
122Rhabdomyosarcoma (HP:0002859)1.60528580
123Trigonocephaly (HP:0000243)1.60512441
124Sloping forehead (HP:0000340)1.60391481
125Absent radius (HP:0003974)1.60190018
126Intestinal malrotation (HP:0002566)1.59917722
127Abnormality of the phalanges of the hallux (HP:0010057)1.59300870
128Broad thumb (HP:0011304)1.57943097
129Aqueductal stenosis (HP:0002410)1.57720637
130Atresia of the external auditory canal (HP:0000413)1.57559963
131Abnormality of the right ventricle (HP:0001707)1.57120755
132Narrow palate (HP:0000189)1.55282660
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.55075473
134Cupped ear (HP:0000378)1.54272031
135Aplasia cutis congenita (HP:0001057)1.54120423
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52441830
137Duodenal stenosis (HP:0100867)1.52154095
138Small intestinal stenosis (HP:0012848)1.52154095
139Duplicated collecting system (HP:0000081)1.51684752
140Thyroid carcinoma (HP:0002890)1.51409637
141Supernumerary bones of the axial skeleton (HP:0009144)1.51368962
142Low anterior hairline (HP:0000294)1.50535691
143Missing ribs (HP:0000921)1.50111666
144Microtia (HP:0008551)1.49642748
145Bladder neoplasm (HP:0009725)1.49328294
146Bladder carcinoma (HP:0002862)1.49328294
147Dislocated radial head (HP:0003083)1.49240791
148Abnormality of the columella (HP:0009929)1.48946705
149Leiomyosarcoma (HP:0100243)1.48868066
150Uterine leiomyosarcoma (HP:0002891)1.48868066
151Optic nerve coloboma (HP:0000588)1.47622158
152Tubulointerstitial nephritis (HP:0001970)1.47077510
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.47056825
154Embryonal neoplasm (HP:0002898)1.45207632
155Myelodysplasia (HP:0002863)1.44827542
156Abnormality of the preputium (HP:0100587)1.44616213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.22076556
2CASK4.21854359
3MARK13.35769732
4WNK33.21508135
5MKNK12.92591353
6ERBB32.92039252
7SRPK12.80997279
8MKNK22.68544144
9BRD42.54469847
10MAP3K42.49973159
11FRK2.34313621
12ZAK2.34197375
13TNIK2.27695666
14NUAK12.26876567
15CDK122.21885522
16SIK21.98248547
17CLK11.98035304
18TAF11.93212282
19PASK1.79127581
20TRPM71.77676655
21STK31.63460456
22PLK31.57533182
23LATS11.54745366
24ATR1.49345692
25STK41.45275282
26BRSK21.44212048
27TLK11.42918583
28CDK61.42475493
29CSNK1A1L1.36131557
30CDK91.35823258
31BCR1.33937296
32TTK1.33233578
33MAP3K91.32417003
34AURKB1.31222771
35PLK41.30489578
36MAP2K71.27993289
37NEK21.26827261
38STK38L1.24496780
39SGK2231.22896827
40SGK4941.22896827
41YES11.22058452
42* ATM1.19176833
43PAK31.16578922
44CHEK11.15180420
45CHEK21.12180708
46KSR11.08014723
47EEF2K1.03992599
48EPHA31.03088802
49INSRR1.02946319
50SGK31.02857153
51BMPR1B1.01906499
52AKT31.01499300
53DYRK21.00682480
54VRK10.99541008
55NTRK20.97829945
56STK240.97321675
57PLK10.97224062
58FGFR30.96240593
59FGFR20.95763415
60TGFBR10.95499887
61MELK0.94756665
62CSNK1G20.91080906
63CHUK0.89866830
64RPS6KB20.89372111
65CDK80.87513396
66CDK70.82262712
67FGFR10.81594358
68PTK60.80358787
69CSNK1G30.79731497
70CSNK1G10.79627896
71HIPK20.79230553
72WNK10.78875808
73RPS6KA40.76330386
74CDK10.76170778
75CAMK1G0.75709733
76MAP3K140.75067017
77NLK0.74714482
78BUB10.74027270
79NEK90.73804998
80RPS6KA50.73466450
81MAP4K20.72938695
82EIF2AK20.72402608
83MAPK130.71966147
84MAP3K100.71318199
85TEC0.69551156
86* CDK20.69359811
87PDGFRB0.68346794
88ACVR1B0.68041484
89TXK0.67507938
90CDK40.66828293
91PRKD30.66468299
92PIK3CG0.65351651
93TRIM280.64821521
94MINK10.62944757
95STK100.62882812
96RPS6KB10.62745832
97MTOR0.60925790
98DYRK30.60845662
99ITK0.60292840
100PNCK0.59515213
101MST40.59313547
102IRAK10.58953137
103PRKDC0.58130398
104WNK40.57841736
105CDK30.56909586
106PDGFRA0.56864910
107MAPK140.55704951
108CSNK1D0.55645269
109SGK20.53916889
110MAP3K60.53160521
111TTN0.52610087
112UHMK10.52355604
113PIK3CA0.51436606
114TSSK60.51195743
115WEE10.50740942
116CSNK1E0.50183119
117CAMK1D0.50042086
118CAMK40.48810116
119DYRK1B0.48627591
120PIM10.48606315
121AKT10.47877223
122MAP2K40.47467714
123EPHB20.47260033
124PBK0.46555178
125RPS6KA60.43744413
126STK110.43387079
127PRKAA20.43194933
128DMPK0.43133382
129ERBB20.42969494
130GSK3B0.41971851
131PLK20.40641933
132CAMKK20.39725475
133SGK10.38893459
134EIF2AK30.35866097
135PRKAA10.35815537

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.54201339
2DNA replication_Homo sapiens_hsa030302.51932981
3Mismatch repair_Homo sapiens_hsa034302.50727986
4Cell cycle_Homo sapiens_hsa041102.38613518
5Fanconi anemia pathway_Homo sapiens_hsa034602.34148341
6Non-homologous end-joining_Homo sapiens_hsa034502.29332677
7Spliceosome_Homo sapiens_hsa030401.88970351
8mRNA surveillance pathway_Homo sapiens_hsa030151.75268191
9Nucleotide excision repair_Homo sapiens_hsa034201.68815884
10RNA degradation_Homo sapiens_hsa030181.68256652
11MicroRNAs in cancer_Homo sapiens_hsa052061.63487148
12Nicotine addiction_Homo sapiens_hsa050331.62089228
13Systemic lupus erythematosus_Homo sapiens_hsa053221.61618997
14Adherens junction_Homo sapiens_hsa045201.61022307
15Basal cell carcinoma_Homo sapiens_hsa052171.56442595
16Base excision repair_Homo sapiens_hsa034101.46458880
17Prostate cancer_Homo sapiens_hsa052151.43253103
18Small cell lung cancer_Homo sapiens_hsa052221.42787329
19RNA transport_Homo sapiens_hsa030131.41609436
20Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39733118
21Protein export_Homo sapiens_hsa030601.35054977
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34757162
23p53 signaling pathway_Homo sapiens_hsa041151.33403387
24Long-term depression_Homo sapiens_hsa047301.26306686
25Viral myocarditis_Homo sapiens_hsa054161.25665631
26Viral carcinogenesis_Homo sapiens_hsa052031.24491098
27TGF-beta signaling pathway_Homo sapiens_hsa043501.18696189
28Colorectal cancer_Homo sapiens_hsa052101.18328059
29HTLV-I infection_Homo sapiens_hsa051661.17522479
30Chronic myeloid leukemia_Homo sapiens_hsa052201.17491903
31Hippo signaling pathway_Homo sapiens_hsa043901.16768064
32One carbon pool by folate_Homo sapiens_hsa006701.16301066
33Wnt signaling pathway_Homo sapiens_hsa043101.14705606
34Basal transcription factors_Homo sapiens_hsa030221.13793849
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11534718
36Taste transduction_Homo sapiens_hsa047421.10431892
37Hedgehog signaling pathway_Homo sapiens_hsa043401.09837981
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.09184671
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08975061
40Herpes simplex infection_Homo sapiens_hsa051681.07555702
41Thyroid cancer_Homo sapiens_hsa052161.06461955
42Endometrial cancer_Homo sapiens_hsa052131.06254713
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04318038
44Hepatitis B_Homo sapiens_hsa051611.02737330
45Alcoholism_Homo sapiens_hsa050341.01376615
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01262499
47Cholinergic synapse_Homo sapiens_hsa047251.00577536
48ECM-receptor interaction_Homo sapiens_hsa045120.98942893
49Pathways in cancer_Homo sapiens_hsa052000.96373799
50Proteoglycans in cancer_Homo sapiens_hsa052050.95907201
51Pancreatic cancer_Homo sapiens_hsa052120.95458743
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94578102
53Dopaminergic synapse_Homo sapiens_hsa047280.92217626
54RNA polymerase_Homo sapiens_hsa030200.91688358
55Propanoate metabolism_Homo sapiens_hsa006400.90899787
56Prolactin signaling pathway_Homo sapiens_hsa049170.90852431
57Focal adhesion_Homo sapiens_hsa045100.90829854
58Primary immunodeficiency_Homo sapiens_hsa053400.89556917
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88338781
60Measles_Homo sapiens_hsa051620.88304438
61Melanoma_Homo sapiens_hsa052180.87522174
62Axon guidance_Homo sapiens_hsa043600.86727022
63ErbB signaling pathway_Homo sapiens_hsa040120.85309082
64Epstein-Barr virus infection_Homo sapiens_hsa051690.84868520
65Glutamatergic synapse_Homo sapiens_hsa047240.84540530
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.83651022
67FoxO signaling pathway_Homo sapiens_hsa040680.83457546
68Morphine addiction_Homo sapiens_hsa050320.82408931
69Hematopoietic cell lineage_Homo sapiens_hsa046400.81867964
70Antigen processing and presentation_Homo sapiens_hsa046120.81837759
71Lysine degradation_Homo sapiens_hsa003100.81074765
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80278436
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80129065
74ABC transporters_Homo sapiens_hsa020100.78522781
75Circadian rhythm_Homo sapiens_hsa047100.78272987
76Tight junction_Homo sapiens_hsa045300.77154255
77Inositol phosphate metabolism_Homo sapiens_hsa005620.76969103
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76154240
79Serotonergic synapse_Homo sapiens_hsa047260.75858892
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75751633
81Gap junction_Homo sapiens_hsa045400.75132396
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74657027
83Circadian entrainment_Homo sapiens_hsa047130.73863464
84T cell receptor signaling pathway_Homo sapiens_hsa046600.73714770
85Cocaine addiction_Homo sapiens_hsa050300.72996133
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72940575
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72736470
88Oocyte meiosis_Homo sapiens_hsa041140.71946765
89Non-small cell lung cancer_Homo sapiens_hsa052230.71620599
90Ribosome_Homo sapiens_hsa030100.71414160
91Fatty acid biosynthesis_Homo sapiens_hsa000610.71179642
92Notch signaling pathway_Homo sapiens_hsa043300.70824444
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70146669
94GABAergic synapse_Homo sapiens_hsa047270.69377382
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68487962
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68076912
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67027657
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66800504
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66785017
100Toxoplasmosis_Homo sapiens_hsa051450.66629265
101cAMP signaling pathway_Homo sapiens_hsa040240.66461063
102Phototransduction_Homo sapiens_hsa047440.66234387
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66178396
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65504943
105Ether lipid metabolism_Homo sapiens_hsa005650.65369222
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65237331
107Estrogen signaling pathway_Homo sapiens_hsa049150.64318353
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.63216838
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63207358
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62989787
111Renal cell carcinoma_Homo sapiens_hsa052110.60882705
112Autoimmune thyroid disease_Homo sapiens_hsa053200.59813030
113Pyrimidine metabolism_Homo sapiens_hsa002400.59576159
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59492599
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.58333857
116B cell receptor signaling pathway_Homo sapiens_hsa046620.56980367
117Ras signaling pathway_Homo sapiens_hsa040140.56608347
118Type II diabetes mellitus_Homo sapiens_hsa049300.56156312
119Dilated cardiomyopathy_Homo sapiens_hsa054140.56016002
120N-Glycan biosynthesis_Homo sapiens_hsa005100.55840226
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54530957
122Platelet activation_Homo sapiens_hsa046110.54379499
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53916348
124Selenocompound metabolism_Homo sapiens_hsa004500.53745962
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52766668
126Acute myeloid leukemia_Homo sapiens_hsa052210.52713315
127Melanogenesis_Homo sapiens_hsa049160.52656617
128mTOR signaling pathway_Homo sapiens_hsa041500.51850996
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51716362
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51663982
131Oxytocin signaling pathway_Homo sapiens_hsa049210.51500264
132Influenza A_Homo sapiens_hsa051640.50343655
133Dorso-ventral axis formation_Homo sapiens_hsa043200.49541534
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48593507
135Glioma_Homo sapiens_hsa052140.48418159
136Graft-versus-host disease_Homo sapiens_hsa053320.48279442
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48217738
138Choline metabolism in cancer_Homo sapiens_hsa052310.48175499
139Apoptosis_Homo sapiens_hsa042100.47342114
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.46479771
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.44407514
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44373621
143Leishmaniasis_Homo sapiens_hsa051400.42976738

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