PBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.85937414
2mesenchymal-epithelial cell signaling (GO:0060638)5.16428669
3pyrimidine nucleobase catabolic process (GO:0006208)4.56705516
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.02097429
5presynaptic membrane organization (GO:0097090)3.97179240
6neuron cell-cell adhesion (GO:0007158)3.84908435
7craniofacial suture morphogenesis (GO:0097094)3.80582176
8central nervous system projection neuron axonogenesis (GO:0021952)3.78152421
9limb bud formation (GO:0060174)3.76381981
10regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.66019672
11sequestering of extracellular ligand from receptor (GO:0035581)3.64825172
12nucleobase catabolic process (GO:0046113)3.58655966
13cell proliferation involved in metanephros development (GO:0072203)3.47895880
14behavioral response to nicotine (GO:0035095)3.40495108
15vocalization behavior (GO:0071625)3.35768019
16cell proliferation involved in kidney development (GO:0072111)3.31387195
17prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.31075091
18axonal fasciculation (GO:0007413)3.30380146
19somite development (GO:0061053)3.29137643
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28677358
21neuron recognition (GO:0008038)3.23985038
22neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.21428508
23glutamate receptor signaling pathway (GO:0007215)3.20089707
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18499474
25dendritic spine morphogenesis (GO:0060997)3.17841829
26regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16258900
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16137857
28synapse assembly (GO:0007416)3.15485953
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.14844201
30mesenchymal cell proliferation (GO:0010463)3.14839334
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10422062
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.10422062
33regulation of translation, ncRNA-mediated (GO:0045974)3.10422062
34layer formation in cerebral cortex (GO:0021819)3.05230205
35positive regulation of dendritic spine morphogenesis (GO:0061003)3.01456359
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01152910
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00475665
38locomotory exploration behavior (GO:0035641)2.97210061
39central nervous system neuron axonogenesis (GO:0021955)2.93265469
40bone trabecula formation (GO:0060346)2.92508638
41negative regulation of catenin import into nucleus (GO:0035414)2.91914124
42postsynaptic membrane organization (GO:0001941)2.91765390
43branching involved in salivary gland morphogenesis (GO:0060445)2.88681220
44regulation of axon extension involved in axon guidance (GO:0048841)2.88530921
45regulation of short-term neuronal synaptic plasticity (GO:0048172)2.88161273
46dendrite morphogenesis (GO:0048813)2.86955024
47serotonin metabolic process (GO:0042428)2.86157349
48neurotransmitter-gated ion channel clustering (GO:0072578)2.85258075
49dendrite development (GO:0016358)2.83195118
50regulation of axon guidance (GO:1902667)2.80343276
51catecholamine biosynthetic process (GO:0042423)2.79759481
52catechol-containing compound biosynthetic process (GO:0009713)2.79759481
53keratinocyte proliferation (GO:0043616)2.79448365
54cell differentiation involved in kidney development (GO:0061005)2.79065796
55presynaptic membrane assembly (GO:0097105)2.78835954
56dermatan sulfate biosynthetic process (GO:0030208)2.78701210
57synaptic transmission, glutamatergic (GO:0035249)2.77588356
58regulation of glutamate receptor signaling pathway (GO:1900449)2.77048992
59neuronal ion channel clustering (GO:0045161)2.76214114
60innervation (GO:0060384)2.75174758
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74233486
62* proximal/distal pattern formation (GO:0009954)2.72170419
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71801040
64branching involved in prostate gland morphogenesis (GO:0060442)2.71728432
65kidney morphogenesis (GO:0060993)2.71687191
66membrane depolarization during action potential (GO:0086010)2.71686757
67exploration behavior (GO:0035640)2.69283353
68tachykinin receptor signaling pathway (GO:0007217)2.68828385
69mesenchymal cell differentiation (GO:0048762)2.68651704
70positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.67967075
71regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.67967075
72metanephric mesenchyme development (GO:0072075)2.67602453
73response to insecticide (GO:0017085)2.67256916
74urinary tract smooth muscle contraction (GO:0014848)2.67216725
75mechanosensory behavior (GO:0007638)2.65861346
76dopaminergic neuron differentiation (GO:0071542)2.65765490
77neuronal action potential (GO:0019228)2.65481921
78negative regulation of stem cell proliferation (GO:2000647)2.65081989
79negative regulation of axon extension involved in axon guidance (GO:0048843)2.64877737
80regulation of posttranscriptional gene silencing (GO:0060147)2.63521502
81regulation of gene silencing by miRNA (GO:0060964)2.63521502
82regulation of gene silencing by RNA (GO:0060966)2.63521502
83convergent extension (GO:0060026)2.63231176
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62689134
85short-term memory (GO:0007614)2.61908480
86radial glial cell differentiation (GO:0060019)2.61111355
87positive regulation of synapse assembly (GO:0051965)2.60620080
88epithelial cell differentiation involved in kidney development (GO:0035850)2.60383519
89retina layer formation (GO:0010842)2.60143086
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60103693
91synaptic vesicle exocytosis (GO:0016079)2.59944316
92glial cell migration (GO:0008347)2.58850441
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58784423
94head development (GO:0060322)2.58238395
95protein localization to synapse (GO:0035418)2.58106236
96synaptic vesicle maturation (GO:0016188)2.57497611
97prostate gland epithelium morphogenesis (GO:0060740)2.57213396
98dopamine biosynthetic process (GO:0042416)2.57153043
99negative regulation of axon guidance (GO:1902668)2.56524682
100cochlea development (GO:0090102)2.56482091
101synapse organization (GO:0050808)2.56315571
102mating behavior (GO:0007617)2.56280219
103axon extension involved in axon guidance (GO:0048846)2.56151363
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.56151363
105establishment of nucleus localization (GO:0040023)2.55276119
106startle response (GO:0001964)2.54521204
107dorsal/ventral axis specification (GO:0009950)2.54222956
108myelination in peripheral nervous system (GO:0022011)2.53779828
109peripheral nervous system axon ensheathment (GO:0032292)2.53779828
110dermatan sulfate metabolic process (GO:0030205)2.53708300
111hindbrain development (GO:0030902)2.53236249
112cerebral cortex radially oriented cell migration (GO:0021799)2.52946130
113regulation of keratinocyte proliferation (GO:0010837)2.52861259
114neuron maturation (GO:0042551)2.52586620
115hindlimb morphogenesis (GO:0035137)2.50552196
116mesonephros development (GO:0001823)2.50531851
117axon extension (GO:0048675)2.49830975
118regulation of pigment cell differentiation (GO:0050932)2.49719077
119ionotropic glutamate receptor signaling pathway (GO:0035235)2.48844431
120cranial suture morphogenesis (GO:0060363)2.48362368
121apical protein localization (GO:0045176)2.48291774
122embryonic forelimb morphogenesis (GO:0035115)2.47766994
123neuron-neuron synaptic transmission (GO:0007270)2.47496472
124kidney mesenchyme development (GO:0072074)2.47166556
125negative regulation of smoothened signaling pathway (GO:0045879)2.46397540
126establishment of mitochondrion localization (GO:0051654)2.46123655
127retinal ganglion cell axon guidance (GO:0031290)2.46122017
128glutamate secretion (GO:0014047)2.45803203
129outer ear morphogenesis (GO:0042473)2.45468988
130positive regulation of gastrulation (GO:2000543)2.43810644
131regulation of smoothened signaling pathway (GO:0008589)2.43701413
132negative regulation of osteoblast proliferation (GO:0033689)2.43657892
133regulation of synapse assembly (GO:0051963)2.43251249
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43119643
135synaptic vesicle docking involved in exocytosis (GO:0016081)2.42851048
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.42757685
137atrial cardiac muscle cell action potential (GO:0086014)2.41279697
138artery smooth muscle contraction (GO:0014824)2.41224264
139response to auditory stimulus (GO:0010996)2.40825896
140regulation of establishment of planar polarity (GO:0090175)2.40644311
141spinal cord development (GO:0021510)2.40519586
142cell migration in hindbrain (GO:0021535)2.39373766
143positive regulation of cardiac muscle cell differentiation (GO:2000727)2.39268426
144neuron migration (GO:0001764)2.38990964
145regulation of synapse structural plasticity (GO:0051823)2.38439468
146toxin metabolic process (GO:0009404)2.38133985
147chondrocyte proliferation (GO:0035988)2.37934590
148calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37220219
149positive regulation of dendritic spine development (GO:0060999)2.37001094
150midbrain development (GO:0030901)2.36554833
151cerebral cortex cell migration (GO:0021795)2.36549521
152glial cell proliferation (GO:0014009)2.35824852
153regulation of cAMP-dependent protein kinase activity (GO:2000479)2.35595728
154adaptation of signaling pathway (GO:0023058)2.35593669
155transmission of nerve impulse (GO:0019226)2.35233567
156negative regulation of axon extension (GO:0030517)2.34734350
157auditory behavior (GO:0031223)2.33787365
158axonogenesis (GO:0007409)2.33614062
159regulation of long-term neuronal synaptic plasticity (GO:0048169)2.33611491
160branching involved in labyrinthine layer morphogenesis (GO:0060670)2.33382066
161primary amino compound metabolic process (GO:1901160)2.33311567
162cartilage morphogenesis (GO:0060536)2.32710837
163regulation of collateral sprouting (GO:0048670)2.32121053
164spinal cord motor neuron differentiation (GO:0021522)2.31725726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68440212
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.97422782
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.60456140
4GBX2_23144817_ChIP-Seq_PC3_Human3.22029840
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88600897
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78281957
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.75634211
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75328499
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.74752080
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67666335
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67666335
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61289638
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53954286
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49525390
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49450306
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48039719
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41630529
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.23728897
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.18458906
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17111243
21AR_21572438_ChIP-Seq_LNCaP_Human2.11844494
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11123981
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99447758
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95328128
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.91522533
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.91295066
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90513838
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83034329
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75078541
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.73177189
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69339855
32P300_19829295_ChIP-Seq_ESCs_Human1.67944459
33* DROSHA_22980978_ChIP-Seq_HELA_Human1.65700915
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.63245636
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.62910446
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61876006
37TAF15_26573619_Chip-Seq_HEK293_Human1.58323059
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55678888
39* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54720601
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53550101
41ZNF274_21170338_ChIP-Seq_K562_Hela1.52236822
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51093124
43* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50836350
44* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50761972
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49680614
46FUS_26573619_Chip-Seq_HEK293_Human1.49458756
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.46899986
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.45946310
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44532773
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44499893
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44026290
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43043176
53* VDR_22108803_ChIP-Seq_LS180_Human1.41993609
54* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40983592
55AHR_22903824_ChIP-Seq_MCF-7_Human1.40405418
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40343486
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37778950
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37220299
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.36983699
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36074602
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35718010
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32836991
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32775150
64* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32055506
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.32037167
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.32003512
67IGF1R_20145208_ChIP-Seq_DFB_Human1.31722909
68TP53_18474530_ChIP-ChIP_U2OS_Human1.30298688
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.29948190
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.29920759
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29120983
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28923710
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28907565
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.27750277
75REST_21632747_ChIP-Seq_MESCs_Mouse1.27333675
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25611281
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25030425
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24918216
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24484894
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23926264
81RNF2_27304074_Chip-Seq_NSC_Mouse1.23872728
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23139455
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22150748
84* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22099250
85* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21125306
86* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21059971
87* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21059971
88AR_25329375_ChIP-Seq_VCAP_Human1.19443411
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.18627260
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16803442
91* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16741522
92TP53_16413492_ChIP-PET_HCT116_Human1.16468075
93EWS_26573619_Chip-Seq_HEK293_Human1.14302680
94* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13592900
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13328556
96STAT3_23295773_ChIP-Seq_U87_Human1.13286978
97SOX9_26525672_Chip-Seq_HEART_Mouse1.12981772
98* AR_19668381_ChIP-Seq_PC3_Human1.12255423
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11925214
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11840013
101RUNX2_22187159_ChIP-Seq_PCA_Human1.10844051
102* BCAT_22108803_ChIP-Seq_LS180_Human1.10785607
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.10234640
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09457624
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.08817402
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08056775
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06378361
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05858449
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.02736194
110CBP_20019798_ChIP-Seq_JUKART_Human1.02129540
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02129540
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01697394
113ER_23166858_ChIP-Seq_MCF-7_Human1.01597863
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.01523224
115TCF4_23295773_ChIP-Seq_U87_Human1.00180718
116* RARB_27405468_Chip-Seq_BRAIN_Mouse0.99654673
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99206597
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.99094305
119* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96492264
120* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96134593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.36325907
2MP0000566_synostosis2.84893544
3MP0002938_white_spotting2.79050120
4MP0003122_maternal_imprinting2.67109571
5MP0004859_abnormal_synaptic_plasticity2.61787348
6MP0005187_abnormal_penis_morphology2.58057704
7MP0000537_abnormal_urethra_morphology2.53425452
8MP0005503_abnormal_tendon_morphology2.50700656
9MP0003880_abnormal_central_pattern2.49780697
10MP0001299_abnormal_eye_distance/2.26507904
11MP0005248_abnormal_Harderian_gland2.20960587
12MP0003890_abnormal_embryonic-extraembry2.13339961
13MP0000778_abnormal_nervous_system2.11290587
14MP0010030_abnormal_orbit_morphology2.07389215
15MP0003385_abnormal_body_wall2.00931417
16MP0003635_abnormal_synaptic_transmissio1.99895877
17* MP0009250_abnormal_appendicular_skeleto1.96858821
18* MP0003942_abnormal_urinary_system1.87723538
19MP0002735_abnormal_chemical_nociception1.81575401
20MP0002282_abnormal_trachea_morphology1.76382842
21MP0000428_abnormal_craniofacial_morphol1.74184353
22MP0002736_abnormal_nociception_after1.65069710
23MP0004272_abnormal_basement_membrane1.64818345
24MP0004133_heterotaxia1.64476577
25MP0000534_abnormal_ureter_morphology1.62715272
26MP0006276_abnormal_autonomic_nervous1.60203607
27MP0003938_abnormal_ear_development1.58892810
28MP0002063_abnormal_learning/memory/cond1.54990871
29MP0003121_genomic_imprinting1.51118827
30MP0002822_catalepsy1.49999564
31MP0003755_abnormal_palate_morphology1.48194787
32MP0001346_abnormal_lacrimal_gland1.46739977
33MP0001188_hyperpigmentation1.44530421
34MP0002572_abnormal_emotion/affect_behav1.43686442
35MP0005409_darkened_coat_color1.43665780
36MP0000516_abnormal_urinary_system1.43576193
37MP0005367_renal/urinary_system_phenotyp1.43576193
38MP0004270_analgesia1.43374847
39MP0005423_abnormal_somatic_nervous1.42809731
40MP0009780_abnormal_chondrocyte_physiolo1.42738408
41* MP0000049_abnormal_middle_ear1.42400266
42MP0001529_abnormal_vocalization1.39758614
43MP0005257_abnormal_intraocular_pressure1.39152869
44MP0001486_abnormal_startle_reflex1.36943161
45MP0002102_abnormal_ear_morphology1.36823284
46MP0002184_abnormal_innervation1.36604079
47* MP0002116_abnormal_craniofacial_bone1.35404104
48MP0003283_abnormal_digestive_organ1.34521026
49* MP0003937_abnormal_limbs/digits/tail_de1.34313489
50MP0000631_abnormal_neuroendocrine_gland1.32970949
51MP0002557_abnormal_social/conspecific_i1.32916301
52MP0009745_abnormal_behavioral_response1.32194481
53* MP0003935_abnormal_craniofacial_develop1.29418520
54MP0002249_abnormal_larynx_morphology1.28804077
55MP0000751_myopathy1.27723241
56MP0002108_abnormal_muscle_morphology1.27469373
57MP0001293_anophthalmia1.26792122
58MP0010368_abnormal_lymphatic_system1.26483755
59MP0009053_abnormal_anal_canal1.25957420
60MP0003787_abnormal_imprinting1.24353510
61MP0004742_abnormal_vestibular_system1.23289456
62MP0002932_abnormal_joint_morphology1.23035325
63MP0003941_abnormal_skin_development1.21826110
64MP0003136_yellow_coat_color1.21669035
65MP0002233_abnormal_nose_morphology1.20876314
66MP0001177_atelectasis1.20105478
67MP0001440_abnormal_grooming_behavior1.20050764
68MP0009046_muscle_twitch1.17720866
69MP0002064_seizures1.16119633
70MP0001970_abnormal_pain_threshold1.14781924
71MP0002697_abnormal_eye_size1.14563379
72MP0002751_abnormal_autonomic_nervous1.14265608
73MP0002734_abnormal_mechanical_nocicepti1.12702971
74MP0002752_abnormal_somatic_nervous1.12228295
75MP0005551_abnormal_eye_electrophysiolog1.11947899
76MP0004134_abnormal_chest_morphology1.11920512
77MP0005646_abnormal_pituitary_gland1.11364777
78MP0001984_abnormal_olfaction1.10269830
79MP0005508_abnormal_skeleton_morphology1.09602501
80MP0003115_abnormal_respiratory_system1.08221787
81MP0003567_abnormal_fetal_cardiomyocyte1.07938701
82MP0001968_abnormal_touch/_nociception1.07879284
83MP0004885_abnormal_endolymph1.07682551
84MP0003861_abnormal_nervous_system1.07262549
85* MP0002177_abnormal_outer_ear1.06292888
86MP0006292_abnormal_olfactory_placode1.06191615
87MP0001485_abnormal_pinna_reflex1.06139533
88MP0000026_abnormal_inner_ear1.05115935
89MP0004142_abnormal_muscle_tone1.03653553
90MP0000955_abnormal_spinal_cord1.02700276
91MP0008789_abnormal_olfactory_epithelium1.02468254
92MP0003119_abnormal_digestive_system1.01432983
93MP0004811_abnormal_neuron_physiology1.00737037
94MP0002882_abnormal_neuron_morphology0.99332622
95MP0001340_abnormal_eyelid_morphology0.99035057
96MP0001286_abnormal_eye_development0.98075848
97MP0009379_abnormal_foot_pigmentation0.98070928
98MP0004924_abnormal_behavior0.97351489
99MP0005386_behavior/neurological_phenoty0.97351489
100MP0001905_abnormal_dopamine_level0.97344588
101MP0005499_abnormal_olfactory_system0.96791499
102MP0005394_taste/olfaction_phenotype0.96791499
103MP0004145_abnormal_muscle_electrophysio0.95512722
104MP0000762_abnormal_tongue_morphology0.95369726
105MP0008877_abnormal_DNA_methylation0.95348092
106MP0002152_abnormal_brain_morphology0.95216964
107* MP0002109_abnormal_limb_morphology0.94946434
108MP0003123_paternal_imprinting0.94946014
109MP0000432_abnormal_head_morphology0.92829429
110* MP0002066_abnormal_motor_capabilities/c0.90852467
111MP0002067_abnormal_sensory_capabilities0.90141958
112MP0002234_abnormal_pharynx_morphology0.89626408
113MP0000579_abnormal_nail_morphology0.89292722
114MP0002638_abnormal_pupillary_reflex0.88945046
115MP0000462_abnormal_digestive_system0.87988251
116MP0005623_abnormal_meninges_morphology0.87739473
117MP0002733_abnormal_thermal_nociception0.85879125
118MP0002081_perinatal_lethality0.85071978
119MP0002837_dystrophic_cardiac_calcinosis0.84782791
120MP0002272_abnormal_nervous_system0.84360218
121MP0002909_abnormal_adrenal_gland0.83791829
122MP0006072_abnormal_retinal_apoptosis0.79923221
123* MP0002114_abnormal_axial_skeleton0.79846634
124MP0002069_abnormal_eating/drinking_beha0.78918958
125MP0005195_abnormal_posterior_eye0.78826899
126MP0004215_abnormal_myocardial_fiber0.78679207
127MP0002896_abnormal_bone_mineralization0.78372497
128MP0001502_abnormal_circadian_rhythm0.78176347
129MP0004085_abnormal_heartbeat0.77658018
130MP0005645_abnormal_hypothalamus_physiol0.75927297
131MP0001963_abnormal_hearing_physiology0.75773978
132* MP0000163_abnormal_cartilage_morphology0.75218612

Predicted human phenotypes

RankGene SetZ-score
1Midline defect of the nose (HP:0004122)5.08986632
2Short 4th metacarpal (HP:0010044)4.89633666
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.89633666
4Abnormality of the parietal bone (HP:0002696)4.74629591
5Trigonocephaly (HP:0000243)3.79174108
6Hyperventilation (HP:0002883)3.57667371
7Abnormality of the 4th metacarpal (HP:0010012)3.53685369
8Shallow orbits (HP:0000586)3.30439652
9Nasolacrimal duct obstruction (HP:0000579)3.26824338
10Abnormality of the nasal septum (HP:0000419)3.15964854
11Abnormality of the lacrimal duct (HP:0011481)3.04490466
12Aplasia involving bones of the extremities (HP:0009825)3.02725164
13Aplasia involving bones of the upper limbs (HP:0009823)3.02725164
14Aplasia of the phalanges of the hand (HP:0009802)3.02725164
15Abnormality of the nasolacrimal system (HP:0000614)3.02697887
16Broad metatarsal (HP:0001783)3.00754016
17Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.87867605
18Anteriorly placed anus (HP:0001545)2.86070056
19Neoplasm of the heart (HP:0100544)2.82193442
20Coronal craniosynostosis (HP:0004440)2.74384752
21Alacrima (HP:0000522)2.73947595
22Humeroradial synostosis (HP:0003041)2.61134038
23Synostosis involving the elbow (HP:0003938)2.61134038
24Protruding tongue (HP:0010808)2.60792065
25Microglossia (HP:0000171)2.47538962
26Febrile seizures (HP:0002373)2.47476794
27Myokymia (HP:0002411)2.46265852
28Abnormality of the labia minora (HP:0012880)2.40384119
29Abnormality of the diencephalon (HP:0010662)2.39783216
30Exostoses (HP:0100777)2.38409261
31Vaginal atresia (HP:0000148)2.38398081
32Concave nail (HP:0001598)2.38280209
33Genital tract atresia (HP:0001827)2.37686447
34Limb dystonia (HP:0002451)2.37637302
35Vitreoretinal degeneration (HP:0000655)2.34406432
36Narrow palate (HP:0000189)2.34351497
37Hypoventilation (HP:0002791)2.32362149
38Anophthalmia (HP:0000528)2.31444362
39Hepatoblastoma (HP:0002884)2.30587986
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.28549603
41Aqueductal stenosis (HP:0002410)2.27329101
42Cutaneous finger syndactyly (HP:0010554)2.27286970
43Decreased lacrimation (HP:0000633)2.25349518
44Increased number of teeth (HP:0011069)2.24994878
45Preaxial foot polydactyly (HP:0001841)2.24598487
46Bronchomalacia (HP:0002780)2.22818770
47Gait imbalance (HP:0002141)2.21469495
48Bell-shaped thorax (HP:0001591)2.21057555
49Abnormality of incisor morphology (HP:0011063)2.17735148
50Infantile muscular hypotonia (HP:0008947)2.17075202
51Abnormality of the pubic bones (HP:0003172)2.15659949
52Abnormality of the ischium (HP:0003174)2.15525378
53Dialeptic seizures (HP:0011146)2.13971328
54Abnormality of the incisor (HP:0000676)2.13923071
55Abnormal number of incisors (HP:0011064)2.13676941
56Absent eyebrow (HP:0002223)2.13450214
57Partial duplication of the phalanx of hand (HP:0009999)2.12121537
58Progressive cerebellar ataxia (HP:0002073)2.10842027
59Morphological abnormality of the middle ear (HP:0008609)2.10576003
60Hypothermia (HP:0002045)2.10378727
61Short phalanx of the thumb (HP:0009660)2.09474529
62Chorioretinal atrophy (HP:0000533)2.08593332
63Broad toe (HP:0001837)2.08280228
64Shawl scrotum (HP:0000049)2.07456329
65Focal motor seizures (HP:0011153)2.06391242
66Nephronophthisis (HP:0000090)2.02837830
67Turricephaly (HP:0000262)2.02073421
68Atonic seizures (HP:0010819)2.01536816
69Aplasia cutis congenita (HP:0001057)1.99156002
70White forelock (HP:0002211)1.99093895
71Bilateral microphthalmos (HP:0007633)1.98181669
72Heterochromia iridis (HP:0001100)1.98032846
73Drooling (HP:0002307)1.97342987
74Excessive salivation (HP:0003781)1.97342987
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94950740
76Buphthalmos (HP:0000557)1.94525039
77Cutaneous syndactyly (HP:0012725)1.94323409
78Polyphagia (HP:0002591)1.92753299
79Myelomeningocele (HP:0002475)1.92001076
80Genetic anticipation (HP:0003743)1.91146914
81Broad hallux (HP:0010055)1.90989588
82Supernumerary ribs (HP:0005815)1.90929653
83Down-sloping shoulders (HP:0200021)1.90702034
84Septo-optic dysplasia (HP:0100842)1.90244913
85Lissencephaly (HP:0001339)1.89595961
86Renal hypoplasia (HP:0000089)1.89045643
87True hermaphroditism (HP:0010459)1.88668286
88Partial duplication of thumb phalanx (HP:0009944)1.88174473
89Hypoplasia of the maxilla (HP:0000327)1.87801695
90Hypoplastic labia majora (HP:0000059)1.87403904
91Abnormality of the middle phalanges of the hand (HP:0009833)1.87294759
92Inability to walk (HP:0002540)1.87077702
93Bicornuate uterus (HP:0000813)1.86393398
94Pancreatic cysts (HP:0001737)1.85745792
95Omphalocele (HP:0001539)1.84852086
96Pancreatic fibrosis (HP:0100732)1.84074814
97Volvulus (HP:0002580)1.83795445
98Gaze-evoked nystagmus (HP:0000640)1.83306421
99Epileptiform EEG discharges (HP:0011182)1.83068155
100Broad face (HP:0000283)1.83003775
101Broad-based gait (HP:0002136)1.82829897
102Intestinal atresia (HP:0011100)1.82690469
103Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.80719244
104Large earlobe (HP:0009748)1.80688044
105Abnormality of the proximal phalanges of the hand (HP:0009834)1.80059088
106Medial flaring of the eyebrow (HP:0010747)1.79790380
107Optic nerve hypoplasia (HP:0000609)1.79371957
108Bifid tongue (HP:0010297)1.78887656
109Generalized tonic-clonic seizures (HP:0002069)1.78816269
110EEG with generalized epileptiform discharges (HP:0011198)1.78773338
111Tented upper lip vermilion (HP:0010804)1.77851531
112Hypoplastic ischia (HP:0003175)1.77713337
113Focal seizures (HP:0007359)1.76309230
114Sparse lateral eyebrow (HP:0005338)1.76283611
115Short metatarsal (HP:0010743)1.76189135
116Hypsarrhythmia (HP:0002521)1.76036000
117Overgrowth (HP:0001548)1.75930887
118Renal duplication (HP:0000075)1.74845625
119Absent speech (HP:0001344)1.74771607
120Absence seizures (HP:0002121)1.74262583
121Cortical dysplasia (HP:0002539)1.74051429
122Abnormality of midbrain morphology (HP:0002418)1.73314131
123Molar tooth sign on MRI (HP:0002419)1.73314131
124Abnormality of the renal medulla (HP:0100957)1.73000147
125Pachygyria (HP:0001302)1.72995052
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.72914602
127Toxemia of pregnancy (HP:0100603)1.72660814
128Abnormality of the middle phalanges of the toes (HP:0010183)1.72530624
129Gastroesophageal reflux (HP:0002020)1.72004274
130Mixed hearing impairment (HP:0000410)1.71009259
131Agitation (HP:0000713)1.70808570
132Choanal stenosis (HP:0000452)1.70684516
133Action tremor (HP:0002345)1.69532963
134Cupped ear (HP:0000378)1.69506237
135Blue irides (HP:0000635)1.69466697
136Congenital primary aphakia (HP:0007707)1.69304794
137Pheochromocytoma (HP:0002666)1.67659158
138Supernumerary bones of the axial skeleton (HP:0009144)1.67608160
139Abnormality of the corticospinal tract (HP:0002492)1.67119531
140Dental malocclusion (HP:0000689)1.66989468
141Patchy hypopigmentation of hair (HP:0011365)1.66977896
142Micropenis (HP:0000054)1.66973019
143Epileptic encephalopathy (HP:0200134)1.66890825
144Accelerated skeletal maturation (HP:0005616)1.65846547
145Macroorchidism (HP:0000053)1.65829954
146Broad thumb (HP:0011304)1.65808275
147Abnormality of the labia majora (HP:0012881)1.65334416
148Poor coordination (HP:0002370)1.64966121
149Labial hypoplasia (HP:0000066)1.64874519
150Long nose (HP:0003189)1.64760095
151Telecanthus (HP:0000506)1.63750215
152Abnormal hair whorl (HP:0010721)1.63188945
153Exotropia (HP:0000577)1.63116317
154Abnormality of salivation (HP:0100755)1.62801284
155Patellar aplasia (HP:0006443)1.62105495
156High anterior hairline (HP:0009890)1.62053720
157Megalencephaly (HP:0001355)1.61691377
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59205251
159Postaxial hand polydactyly (HP:0001162)1.57107637
160Specific learning disability (HP:0001328)1.55474656
161Progressive inability to walk (HP:0002505)1.55232661
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.53313689
163Sleep apnea (HP:0010535)1.52389553
164Absent hair (HP:0002298)1.52253039
165Scrotal hypoplasia (HP:0000046)1.51075041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.98149075
2FGFR23.35675247
3CASK2.71856119
4EPHA42.64395992
5LATS12.52171141
6MAP3K42.49556712
7NTRK32.32386317
8EPHB22.20316476
9MAP2K72.11773497
10MAPK132.06472166
11DDR22.04416702
12NTRK21.99401915
13ERBB31.86039125
14CAMK1G1.81769550
15SIK21.74461475
16PNCK1.73922503
17MINK11.73449520
18PLK21.66630818
19LATS21.54175327
20MAP3K121.44778350
21KSR11.44726301
22PDGFRA1.44091289
23MAP3K91.38866193
24MAP2K41.37360648
25FGFR11.35939027
26DMPK1.35366751
27FER1.27523750
28CSNK1G21.19283804
29EPHA31.17191630
30DYRK21.16232793
31PAK61.15914898
32SGK21.13579512
33UHMK11.12672240
34SIK31.12483752
35ADRBK21.11014880
36OBSCN1.08414358
37PIK3CA1.06592291
38BMPR1B1.04184214
39CDK51.03450493
40TYRO31.02290224
41CSNK1G11.00875149
42WNK31.00534587
43CSNK1A1L0.99143282
44CSNK1G30.98791280
45CAMK1D0.97515762
46MAPK150.97474377
47SIK10.95472406
48DYRK30.93303897
49DAPK20.91860314
50PHKG10.91702979
51PHKG20.91702979
52RET0.90217785
53PINK10.89279513
54TAF10.86590647
55SGK2230.86587453
56SGK4940.86587453
57PKN10.86398512
58CAMK40.85048632
59TGFBR10.84505547
60SGK30.83568089
61PAK30.81856602
62INSRR0.81494054
63TRIM280.81437230
64TNIK0.80675938
65MARK20.79342602
66GRK10.78858671
67MAPKAPK50.78708420
68PRKD30.77588432
69STK38L0.76020899
70WEE10.74862966
71CAMK2A0.74590573
72ADRBK10.74452089
73DYRK1A0.73747498
74ROCK10.73439674
75OXSR10.73150067
76PRKCE0.72957542
77MKNK10.70921548
78FRK0.70896335
79PRKCG0.70550883
80CAMK10.69659494
81PTK2B0.67561468
82NUAK10.64561610
83PDGFRB0.64396386
84TIE10.61908804
85MKNK20.60710934
86CAMK2B0.60233678
87STK390.59194069
88PRKCH0.59128862
89BRD40.58754764
90STK110.58639213
91CDK30.58496296
92CDK180.57769815
93CDK140.57623625
94ERBB20.56896884
95ACVR1B0.55751447
96AKT30.53113992
97SGK10.53053566
98BCR0.52456544
99CDC42BPA0.52119843
100CDK150.52105327
101HIPK20.51325504
102CSNK1E0.50675279
103PLK30.50491113
104PRPF4B0.50366193
105NTRK10.49532054
106WNK40.49344239
107PRKCZ0.49337598
108PTK20.48432361
109WNK10.48122261
110STK380.47321357
111RPS6KA20.46443656
112CAMKK10.44957893
113CAMK2D0.44644531
114GRK50.44250490
115CDK190.44039087
116MAPK80.43872581
117MAP3K20.42007972
118CDK11A0.41914206
119MAP3K100.41626907
120PKN20.40225784
121PRKACB0.39668003
122CSNK1D0.39131421
123NEK20.37281148
124PRKG10.36037898
125GSK3B0.35014687
126PRKACA0.34996167
127CAMK2G0.34887065
128STK30.33483148

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.71230334
2Basal cell carcinoma_Homo sapiens_hsa052172.61600538
3Hedgehog signaling pathway_Homo sapiens_hsa043402.51842659
4Amphetamine addiction_Homo sapiens_hsa050312.17926054
5Cocaine addiction_Homo sapiens_hsa050302.06448738
6Circadian entrainment_Homo sapiens_hsa047132.06413087
7Axon guidance_Homo sapiens_hsa043601.98250357
8Dopaminergic synapse_Homo sapiens_hsa047281.90802771
9Glutamatergic synapse_Homo sapiens_hsa047241.84954895
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84178875
11Wnt signaling pathway_Homo sapiens_hsa043101.82474011
12Long-term potentiation_Homo sapiens_hsa047201.77897657
13GABAergic synapse_Homo sapiens_hsa047271.76125771
14Morphine addiction_Homo sapiens_hsa050321.73029892
15Olfactory transduction_Homo sapiens_hsa047401.67626941
16Renin secretion_Homo sapiens_hsa049241.65624201
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63771403
18Cholinergic synapse_Homo sapiens_hsa047251.62417786
19Synaptic vesicle cycle_Homo sapiens_hsa047211.62097584
20Melanogenesis_Homo sapiens_hsa049161.57746440
21Serotonergic synapse_Homo sapiens_hsa047261.55418005
22Gap junction_Homo sapiens_hsa045401.50447761
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48800810
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47249893
25Insulin secretion_Homo sapiens_hsa049111.47204728
26Taste transduction_Homo sapiens_hsa047421.44249457
27Long-term depression_Homo sapiens_hsa047301.42509588
28Dilated cardiomyopathy_Homo sapiens_hsa054141.41352800
29Salivary secretion_Homo sapiens_hsa049701.40975706
30Hippo signaling pathway_Homo sapiens_hsa043901.39412029
31Gastric acid secretion_Homo sapiens_hsa049711.36717056
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34054529
33cAMP signaling pathway_Homo sapiens_hsa040241.32470047
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28467997
35Melanoma_Homo sapiens_hsa052181.28440268
36Oxytocin signaling pathway_Homo sapiens_hsa049211.27995825
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25962420
38ErbB signaling pathway_Homo sapiens_hsa040121.22193800
39ECM-receptor interaction_Homo sapiens_hsa045121.21980092
40Phototransduction_Homo sapiens_hsa047441.20350778
41GnRH signaling pathway_Homo sapiens_hsa049121.20023574
42Calcium signaling pathway_Homo sapiens_hsa040201.19806922
43Glioma_Homo sapiens_hsa052141.19660342
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19272286
45Colorectal cancer_Homo sapiens_hsa052101.17252156
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15281645
47Endometrial cancer_Homo sapiens_hsa052131.14449596
48TGF-beta signaling pathway_Homo sapiens_hsa043501.12710847
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06457470
50Adherens junction_Homo sapiens_hsa045201.06274150
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06216034
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06047993
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05635932
54Rap1 signaling pathway_Homo sapiens_hsa040151.05205784
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05172959
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04934712
57Estrogen signaling pathway_Homo sapiens_hsa049151.03822534
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03820939
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00321407
60Proteoglycans in cancer_Homo sapiens_hsa052050.99841631
61Pathways in cancer_Homo sapiens_hsa052000.97857716
62Focal adhesion_Homo sapiens_hsa045100.96538054
63Type II diabetes mellitus_Homo sapiens_hsa049300.96489998
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94733232
65MAPK signaling pathway_Homo sapiens_hsa040100.91898006
66Linoleic acid metabolism_Homo sapiens_hsa005910.91369899
67Ether lipid metabolism_Homo sapiens_hsa005650.91308267
68Ras signaling pathway_Homo sapiens_hsa040140.90789738
69Steroid biosynthesis_Homo sapiens_hsa001000.89057587
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88790528
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88566099
72Butanoate metabolism_Homo sapiens_hsa006500.84578775
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.82951026
74MicroRNAs in cancer_Homo sapiens_hsa052060.80221771
75Renal cell carcinoma_Homo sapiens_hsa052110.79524864
76Nitrogen metabolism_Homo sapiens_hsa009100.77184637
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.76519836
78Dorso-ventral axis formation_Homo sapiens_hsa043200.76433978
79Oocyte meiosis_Homo sapiens_hsa041140.76262829
80Prostate cancer_Homo sapiens_hsa052150.75663285
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74128869
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72671746
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70189911
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68859307
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.68365212
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68320858
87Choline metabolism in cancer_Homo sapiens_hsa052310.68112015
88Histidine metabolism_Homo sapiens_hsa003400.67083604
89Ovarian steroidogenesis_Homo sapiens_hsa049130.66841712
90Basal transcription factors_Homo sapiens_hsa030220.66835546
91Alcoholism_Homo sapiens_hsa050340.65557977
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64616326
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64532159
94Cardiac muscle contraction_Homo sapiens_hsa042600.64421216
95Tryptophan metabolism_Homo sapiens_hsa003800.64153825
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.63369054
97Selenocompound metabolism_Homo sapiens_hsa004500.60402031
98Thyroid hormone synthesis_Homo sapiens_hsa049180.60097037
99Tight junction_Homo sapiens_hsa045300.59695350
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59606979
101Non-small cell lung cancer_Homo sapiens_hsa052230.59396964
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59155242
103Amoebiasis_Homo sapiens_hsa051460.57617954
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57043889
105Circadian rhythm_Homo sapiens_hsa047100.56792525
106Glucagon signaling pathway_Homo sapiens_hsa049220.55533571
107Chronic myeloid leukemia_Homo sapiens_hsa052200.55140417
108Insulin signaling pathway_Homo sapiens_hsa049100.54496705
109Viral myocarditis_Homo sapiens_hsa054160.53633427
110Lysine degradation_Homo sapiens_hsa003100.53457270
111Platelet activation_Homo sapiens_hsa046110.51746491
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50567979
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49816039
114Protein digestion and absorption_Homo sapiens_hsa049740.47497535
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47056559
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46211140
117Alzheimers disease_Homo sapiens_hsa050100.46079160
118Parkinsons disease_Homo sapiens_hsa050120.45716539
119Pancreatic secretion_Homo sapiens_hsa049720.44768717
120Prolactin signaling pathway_Homo sapiens_hsa049170.44510438
121Notch signaling pathway_Homo sapiens_hsa043300.44140947
122Tyrosine metabolism_Homo sapiens_hsa003500.42538890
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42120445
124Huntingtons disease_Homo sapiens_hsa050160.41879604

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