PBX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.68514471
2positive regulation of gamma-delta T cell activation (GO:0046645)4.76321852
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62988830
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.62988830
5modulation by symbiont of host immune response (GO:0052553)4.62988830
6positive regulation by symbiont of host defense response (GO:0052509)4.62988830
7modulation by symbiont of host defense response (GO:0052031)4.62988830
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62988830
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26783252
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.26416345
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.11303356
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.09771053
13antigen processing and presentation of endogenous antigen (GO:0019883)4.07122867
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91029541
15detection of other organism (GO:0098543)3.88178997
16paraxial mesoderm development (GO:0048339)3.83015156
17peptidyl-lysine dimethylation (GO:0018027)3.78895609
18detection of bacterium (GO:0016045)3.75430551
19polarized epithelial cell differentiation (GO:0030859)3.71628880
20glucocorticoid receptor signaling pathway (GO:0042921)3.67172744
21regulation of gamma-delta T cell activation (GO:0046643)3.64715988
22heterochromatin organization (GO:0070828)3.64574370
23RNA stabilization (GO:0043489)3.60659923
24mRNA stabilization (GO:0048255)3.60659923
25establishment of apical/basal cell polarity (GO:0035089)3.52043336
26response to peptidoglycan (GO:0032494)3.51340700
27regulation of gamma-delta T cell differentiation (GO:0045586)3.47557173
28detection of external biotic stimulus (GO:0098581)3.41855842
29hippo signaling (GO:0035329)3.41159675
30detection of molecule of bacterial origin (GO:0032490)3.38073839
31response to muramyl dipeptide (GO:0032495)3.37604086
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.37504624
33maternal placenta development (GO:0001893)3.37382399
34macrophage activation involved in immune response (GO:0002281)3.33759639
35leukocyte aggregation (GO:0070486)3.30739775
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27469010
37regulation of B cell receptor signaling pathway (GO:0050855)3.26611899
38cytoplasmic mRNA processing body assembly (GO:0033962)3.26512303
39histone H3-K36 demethylation (GO:0070544)3.25765507
40outer ear morphogenesis (GO:0042473)3.23735586
41embryonic foregut morphogenesis (GO:0048617)3.23220402
42regulation of gene silencing by RNA (GO:0060966)3.21685635
43regulation of posttranscriptional gene silencing (GO:0060147)3.21685635
44regulation of gene silencing by miRNA (GO:0060964)3.21685635
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21182453
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20801038
47positive regulation of histone deacetylation (GO:0031065)3.20288052
48positive thymic T cell selection (GO:0045059)3.17199151
49neutrophil activation involved in immune response (GO:0002283)3.16366062
50insulin-like growth factor receptor signaling pathway (GO:0048009)3.15290258
51response to interleukin-15 (GO:0070672)3.13682682
52detection of biotic stimulus (GO:0009595)3.11493753
53cellular extravasation (GO:0045123)3.11054619
54mannose metabolic process (GO:0006013)3.07014605
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04131262
56response to host (GO:0075136)3.04131262
57response to host defenses (GO:0052200)3.04131262
58response to host immune response (GO:0052572)3.01559628
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01559628
60adherens junction assembly (GO:0034333)3.01077916
61thymic T cell selection (GO:0045061)2.99232470
62antigen processing and presentation via MHC class Ib (GO:0002475)2.99214723
63negative regulation of lymphocyte mediated immunity (GO:0002707)2.98965469
64B cell receptor signaling pathway (GO:0050853)2.97426902
65embryonic process involved in female pregnancy (GO:0060136)2.97100450
66intracellular estrogen receptor signaling pathway (GO:0030520)2.96669113
67establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.95992295
68positive regulation of SMAD protein import into nucleus (GO:0060391)2.95985332
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94326746
70NLS-bearing protein import into nucleus (GO:0006607)2.93615229
71germinal center formation (GO:0002467)2.92880420
72gastrulation with mouth forming second (GO:0001702)2.92060376
73regulation of histone H3-K27 methylation (GO:0061085)2.91519304
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91366917
75negative regulation of RNA splicing (GO:0033119)2.91237912
76regulation of stem cell maintenance (GO:2000036)2.90430223
77negative regulation of histone methylation (GO:0031061)2.89562801
78corticosteroid receptor signaling pathway (GO:0031958)2.87536147
79response to laminar fluid shear stress (GO:0034616)2.85169600
80regulation of interferon-beta biosynthetic process (GO:0045357)2.84965187
81negative regulation of DNA repair (GO:0045738)2.84848380
82establishment or maintenance of monopolar cell polarity (GO:0061339)2.84081516
83establishment of monopolar cell polarity (GO:0061162)2.84081516
84peptidyl-arginine omega-N-methylation (GO:0035247)2.82664530
85regulation of establishment of planar polarity (GO:0090175)2.82259058
86positive regulation of RNA splicing (GO:0033120)2.82253344
87regulation of leukocyte degranulation (GO:0043300)2.80758224
88regulation of sister chromatid cohesion (GO:0007063)2.79976621
89body morphogenesis (GO:0010171)2.79583024
90negative thymic T cell selection (GO:0045060)2.79380742
91Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77368510
92negative regulation of toll-like receptor signaling pathway (GO:0034122)2.77294296
93leukocyte migration involved in inflammatory response (GO:0002523)2.76143454
94negative regulation of leukocyte mediated immunity (GO:0002704)2.75449004
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75251715
96regulation of mRNA stability (GO:0043488)2.75242638
97dorsal/ventral axis specification (GO:0009950)2.75153628
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.74661350
99negative regulation of erythrocyte differentiation (GO:0045647)2.74351712
100modulation by virus of host process (GO:0019054)2.71943446
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.71108974
102T cell selection (GO:0045058)2.68330286
103negative regulation of mRNA processing (GO:0050686)2.68156801
104trophectodermal cell differentiation (GO:0001829)2.66675217
1053-UTR-mediated mRNA stabilization (GO:0070935)2.66664179
106regulation of mast cell degranulation (GO:0043304)2.66477967
107modulation by symbiont of host cellular process (GO:0044068)2.65971802
108respiratory burst (GO:0045730)2.65735203
109regulation of T-helper 2 cell differentiation (GO:0045628)2.65515584
110DNA unwinding involved in DNA replication (GO:0006268)2.63777845
111peptidyl-arginine N-methylation (GO:0035246)2.63104913
112peptidyl-arginine methylation (GO:0018216)2.63104913
113positive regulation of cellular amide metabolic process (GO:0034250)2.62760945
114non-canonical Wnt signaling pathway (GO:0035567)2.61902305
115negative regulation of GTPase activity (GO:0034260)2.61080318
116negative regulation of GTP catabolic process (GO:0033125)2.61080318
117cell-substrate adherens junction assembly (GO:0007045)2.60879733
118focal adhesion assembly (GO:0048041)2.60879733
119mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.60085972
120negative T cell selection (GO:0043383)2.59901412
121negative regulation of interleukin-12 production (GO:0032695)2.59603249
122nucleosome disassembly (GO:0006337)2.59360969
123protein-DNA complex disassembly (GO:0032986)2.59360969
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57330311
125embryonic hindlimb morphogenesis (GO:0035116)2.56951745
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.56584275
127hindlimb morphogenesis (GO:0035137)2.56192012
128histone H2A monoubiquitination (GO:0035518)2.55486760
129chromatin assembly (GO:0031497)2.55073944
130regulation of hippo signaling (GO:0035330)2.54988003
131histone lysine demethylation (GO:0070076)2.54701044
132negative regulation of mRNA metabolic process (GO:1903312)2.54593213
133regulation of B cell differentiation (GO:0045577)2.54574898
134regulation of translational fidelity (GO:0006450)2.54567679
135regulation of RNA stability (GO:0043487)2.54462389
136cochlea morphogenesis (GO:0090103)2.54365333
137positive regulation of B cell differentiation (GO:0045579)2.53912259
138head development (GO:0060322)2.52757219
139convergent extension (GO:0060026)2.52080034
140negative regulation of cell size (GO:0045792)2.51388895
141regulation of SMAD protein import into nucleus (GO:0060390)2.51174737
142regulation of heart morphogenesis (GO:2000826)2.51145767
143positive T cell selection (GO:0043368)2.50824151
144protein localization to endosome (GO:0036010)2.50224381
145negative regulation of Ras GTPase activity (GO:0034261)2.49696731
146negative regulation of phagocytosis (GO:0050765)2.49626474
147histone H3-K9 demethylation (GO:0033169)2.49486531
148regulation of necroptotic process (GO:0060544)2.49295320
149natural killer cell differentiation (GO:0001779)2.49241303
150negative regulation of cell killing (GO:0031342)2.49136335
151negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49136335
152megakaryocyte development (GO:0035855)2.48906987
153ectodermal placode formation (GO:0060788)2.47817459
154negative regulation of glial cell proliferation (GO:0060253)2.47743545
155negative regulation of nucleotide catabolic process (GO:0030812)2.47636603
156negative regulation of myotube differentiation (GO:0010832)2.47629345
157positive regulation of transcription regulatory region DNA binding (GO:2000679)2.47438158
158spliceosomal tri-snRNP complex assembly (GO:0000244)2.47335530
159regulation of RNA export from nucleus (GO:0046831)2.46856612
160coronary vasculature morphogenesis (GO:0060977)2.46697602
161neural tube closure (GO:0001843)2.46170515
162germ cell migration (GO:0008354)2.46169466
163anatomical structure regression (GO:0060033)2.45855988
164alternative mRNA splicing, via spliceosome (GO:0000380)2.44112332
165cellular response to virus (GO:0098586)2.43595735
166regulation of nucleobase-containing compound transport (GO:0032239)2.42766784
167respiratory tube development (GO:0030323)2.42654432
168negative regulation of T cell mediated immunity (GO:0002710)2.42511460
169regulation of ARF GTPase activity (GO:0032312)2.42388211
170tube closure (GO:0060606)2.41270396
171regulation of chromatin binding (GO:0035561)2.40374771
172neutrophil activation (GO:0042119)2.39911993
173apoptotic process involved in morphogenesis (GO:0060561)2.39462522
174cortical actin cytoskeleton organization (GO:0030866)2.39229224
175histone demethylation (GO:0016577)2.38648373
176regulation of NFAT protein import into nucleus (GO:0051532)2.38548772
177establishment or maintenance of bipolar cell polarity (GO:0061245)2.38436781
178establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38436781
179lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37962559
180negative regulation of type 2 immune response (GO:0002829)2.37757909
181signal complex assembly (GO:0007172)2.36715545
182pinocytosis (GO:0006907)2.36154345
183positive regulation of gene expression, epigenetic (GO:0045815)2.35711286
184regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35271211
185morphogenesis of an endothelium (GO:0003159)2.34515224
186endothelial tube morphogenesis (GO:0061154)2.34515224
187negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34302811
188stress fiber assembly (GO:0043149)2.33930855
189regulation of regulated secretory pathway (GO:1903305)2.33791479
190regulation of T cell tolerance induction (GO:0002664)2.33555391
191mitotic sister chromatid cohesion (GO:0007064)2.33287832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.88104979
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.62281041
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.57353037
4MYC_22102868_ChIP-Seq_BL_Human3.46400230
5E2F7_22180533_ChIP-Seq_HELA_Human3.43305318
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.13329756
7KDM2B_26808549_Chip-Seq_DND41_Human2.80195275
8* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.62025217
9VDR_21846776_ChIP-Seq_THP-1_Human2.61583566
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61111715
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.60714409
12TCF7_22412390_ChIP-Seq_EML_Mouse2.54834710
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.43875735
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42633342
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.39079291
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.38302074
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.32770805
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29729139
19* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.26298830
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22133083
21KDM2B_26808549_Chip-Seq_JURKAT_Human2.16745952
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15160246
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06933152
24* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.01375195
25KDM2B_26808549_Chip-Seq_K562_Human1.99458861
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.97461879
27* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92764586
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92225193
29LXR_22292898_ChIP-Seq_THP-1_Human1.91679339
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.91029374
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.90792014
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90362857
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87086611
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.85408248
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83782888
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.82939941
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81416205
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81218533
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78376757
40SPI1_23127762_ChIP-Seq_K562_Human1.76582599
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75959550
42CLOCK_20551151_ChIP-Seq_293T_Human1.72270491
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71153172
44RACK7_27058665_Chip-Seq_MCF-7_Human1.68403285
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.67497830
46UTX_26944678_Chip-Seq_JUKART_Human1.65879773
47SCL_19346495_ChIP-Seq_HPC-7_Human1.63830229
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61595845
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60247422
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60247422
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60247422
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58177479
53CREB1_26743006_Chip-Seq_LNCaP_Human1.55741556
54* MAF_26560356_Chip-Seq_TH1_Human1.53181846
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52286389
56* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49752231
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46207926
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45791297
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.43059255
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42319516
61* SPI1_23547873_ChIP-Seq_NB4_Human1.41811043
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.41581810
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41213827
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41207031
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41045004
66VDR_24763502_ChIP-Seq_THP-1_Human1.40414966
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38820835
68MYB_26560356_Chip-Seq_TH1_Human1.37892622
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37555325
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36603229
71NCOR1_26117541_ChIP-Seq_K562_Human1.36258851
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35942944
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.35423467
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34970640
75FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32311634
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.31099530
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31041555
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.28591582
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27738458
80RUNX_20019798_ChIP-Seq_JUKART_Human1.27632815
81MYB_26560356_Chip-Seq_TH2_Human1.25270006
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.25202681
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24311008
84ZNF263_19887448_ChIP-Seq_K562_Human1.23514574
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22468736
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22138335
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21554689
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21085252
89NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18373725
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17813747
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16693331
92* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16671416
93TP53_22127205_ChIP-Seq_IMR90_Human1.15535142
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15294254
95* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14840416
96CHD1_26751641_Chip-Seq_LNCaP_Human1.14392340
97ATF3_27146783_Chip-Seq_COLON_Human1.14036696
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13335283
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11397402
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10443984
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.10426259
102CIITA_25753668_ChIP-Seq_RAJI_Human1.08855858
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.08780367
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08756908
105* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08276949
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08156689
107* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07400497
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07147438
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07054173
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06033869
111SMC4_20622854_ChIP-Seq_HELA_Human1.05144712
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05039716
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04781426
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.04212611
115* MAF_26560356_Chip-Seq_TH2_Human1.03924574
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03860858
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02429682
118* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01223465
119SA1_27219007_Chip-Seq_ERYTHROID_Human1.00723372
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00168840
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00066316
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98536136
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97136192
124POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96308964
125KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96260173
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96212102
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96114991
128KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95837367
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95794558
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94886613
131* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94822751
132P68_20966046_ChIP-Seq_HELA_Human0.94536060
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.93936704
134GATA1_19941826_ChIP-Seq_K562_Human0.93747946
135TRIM28_21343339_ChIP-Seq_HEK293_Human0.92944778
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92538376
137CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91980741
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91237017
139UBF1/2_26484160_Chip-Seq_HMECs_Human0.91197601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.54170322
2MP0003436_decreased_susceptibility_to3.48578603
3MP0000537_abnormal_urethra_morphology3.23938883
4MP0009053_abnormal_anal_canal3.14062020
5MP0010030_abnormal_orbit_morphology3.00358118
6MP0003123_paternal_imprinting3.00225634
7MP0005076_abnormal_cell_differentiation2.92491278
8MP0003724_increased_susceptibility_to2.76690754
9MP0009278_abnormal_bone_marrow2.75256542
10MP0003122_maternal_imprinting2.64067972
11MP0005451_abnormal_body_composition2.59531306
12MP0002396_abnormal_hematopoietic_system2.46802156
13MP0003385_abnormal_body_wall2.42666755
14MP0008260_abnormal_autophagy2.26855638
15MP0001835_abnormal_antigen_presentation2.19959657
16MP0002419_abnormal_innate_immunity2.14388307
17MP0003119_abnormal_digestive_system2.10470683
18MP0003121_genomic_imprinting2.06270198
19MP0000685_abnormal_immune_system2.05196757
20MP0004185_abnormal_adipocyte_glucose2.04213210
21MP0003763_abnormal_thymus_physiology2.03727157
22MP0003303_peritoneal_inflammation2.02652645
23MP0003172_abnormal_lysosome_physiology1.97681719
24MP0005025_abnormal_response_to1.95853925
25MP0004272_abnormal_basement_membrane1.89816937
26MP0001800_abnormal_humoral_immune1.89777660
27MP0005623_abnormal_meninges_morphology1.85980473
28MP0004197_abnormal_fetal_growth/weight/1.84548682
29MP0010368_abnormal_lymphatic_system1.82772717
30MP0003191_abnormal_cellular_cholesterol1.80747248
31MP0001849_ear_inflammation1.80441790
32MP0005000_abnormal_immune_tolerance1.79552895
33MP0001790_abnormal_immune_system1.79402806
34MP0005387_immune_system_phenotype1.79402806
35MP0000428_abnormal_craniofacial_morphol1.78802289
36MP0002653_abnormal_ependyma_morphology1.78691515
37MP0004947_skin_inflammation1.77018847
38MP0005464_abnormal_platelet_physiology1.76984878
39MP0005187_abnormal_penis_morphology1.76955251
40MP0002420_abnormal_adaptive_immunity1.74439541
41MP0000534_abnormal_ureter_morphology1.74222564
42MP0010352_gastrointestinal_tract_polyps1.73933161
43MP0000733_abnormal_muscle_development1.73685393
44MP0003828_pulmonary_edema1.73655279
45MP0001819_abnormal_immune_cell1.73118988
46MP0003567_abnormal_fetal_cardiomyocyte1.72733838
47MP0002398_abnormal_bone_marrow1.72591405
48MP0002084_abnormal_developmental_patter1.71947168
49MP0003300_gastrointestinal_ulcer1.69915706
50MP0010234_abnormal_vibrissa_follicle1.69098905
51MP0002085_abnormal_embryonic_tissue1.67716220
52MP0003283_abnormal_digestive_organ1.67684026
53MP0008961_abnormal_basal_metabolism1.67240236
54MP0003115_abnormal_respiratory_system1.66853420
55MP0005409_darkened_coat_color1.65450207
56MP0002723_abnormal_immune_serum1.65355058
57MP0000858_altered_metastatic_potential1.65175236
58MP0000703_abnormal_thymus_morphology1.65022005
59MP0003942_abnormal_urinary_system1.64568314
60MP0003935_abnormal_craniofacial_develop1.62335224
61MP0005058_abnormal_lysosome_morphology1.62087734
62MP0002249_abnormal_larynx_morphology1.60721652
63MP0002452_abnormal_antigen_presenting1.59696561
64MP0002932_abnormal_joint_morphology1.56969058
65MP0003566_abnormal_cell_adhesion1.56565533
66MP0001730_embryonic_growth_arrest1.55196382
67MP0001533_abnormal_skeleton_physiology1.53568404
68MP0002132_abnormal_respiratory_system1.53526604
69MP0002405_respiratory_system_inflammati1.52056351
70MP0002086_abnormal_extraembryonic_tissu1.51873964
71MP0005380_embryogenesis_phenotype1.51319989
72MP0001672_abnormal_embryogenesis/_devel1.51319989
73MP0009333_abnormal_splenocyte_physiolog1.47641489
74MP0002925_abnormal_cardiovascular_devel1.47304242
75MP0009672_abnormal_birth_weight1.47003585
76MP0002282_abnormal_trachea_morphology1.45609445
77MP0000716_abnormal_immune_system1.45549781
78MP0002088_abnormal_embryonic_growth/wei1.45542170
79MP0003984_embryonic_growth_retardation1.44148180
80MP0003937_abnormal_limbs/digits/tail_de1.43635271
81MP0002722_abnormal_immune_system1.43514074
82MP0001697_abnormal_embryo_size1.43435500
83MP0004381_abnormal_hair_follicle1.42194466
84MP0002697_abnormal_eye_size1.40948672
85MP0009703_decreased_birth_body1.39264743
86MP0004233_abnormal_muscle_weight1.37324295
87MP0000516_abnormal_urinary_system1.36038483
88MP0005367_renal/urinary_system_phenotyp1.36038483
89MP0000049_abnormal_middle_ear1.33970668
90MP0005671_abnormal_response_to1.33556321
91MP0005248_abnormal_Harderian_gland1.31087631
92MP0002429_abnormal_blood_cell1.29449749
93MP0002998_abnormal_bone_remodeling1.29334087
94MP0010155_abnormal_intestine_physiology1.28473934
95MP0001851_eye_inflammation1.28096918
96MP0002009_preneoplasia1.26510911
97MP0000689_abnormal_spleen_morphology1.25202754
98MP0001879_abnormal_lymphatic_vessel1.25007981
99MP0002877_abnormal_melanocyte_morpholog1.23696055
100MP0009785_altered_susceptibility_to1.23246097
101MP0005167_abnormal_blood-brain_barrier1.21273934
102MP0003453_abnormal_keratinocyte_physiol1.19102298
103MP0000350_abnormal_cell_proliferation1.18608048
104MP0004808_abnormal_hematopoietic_stem1.13699230
105MP0002080_prenatal_lethality1.13050379
106MP0001915_intracranial_hemorrhage1.13012496
107MP0010630_abnormal_cardiac_muscle1.12142793
108MP0002166_altered_tumor_susceptibility1.11928743
109MP0002116_abnormal_craniofacial_bone1.09686368
110MP0009250_abnormal_appendicular_skeleto1.09448947
111MP0002092_abnormal_eye_morphology1.09270115
112MP0003755_abnormal_palate_morphology1.07920054
113MP0010307_abnormal_tumor_latency1.07426733
114MP0000266_abnormal_heart_morphology1.06455819
115MP0001293_anophthalmia1.05677643
116MP0003861_abnormal_nervous_system1.03574834
117MP0003183_abnormal_peptide_metabolism1.03368425
118MP0000767_abnormal_smooth_muscle1.03347163
119MP0006082_CNS_inflammation1.03233679
120MP0003111_abnormal_nucleus_morphology1.02763583
121MP0002111_abnormal_tail_morphology1.00933689
122MP0003315_abnormal_perineum_morphology1.00424416
123MP0003866_abnormal_defecation1.00159404
124MP0002089_abnormal_postnatal_growth/wei0.99315813
125MP0000432_abnormal_head_morphology0.98899739
126MP0004510_myositis0.98482639
127MP0005666_abnormal_adipose_tissue0.98065289
128MP0005375_adipose_tissue_phenotype0.97855943
129MP0001784_abnormal_fluid_regulation0.96927291
130MP0004957_abnormal_blastocyst_morpholog0.94439239
131MP0005023_abnormal_wound_healing0.94346244
132MP0001614_abnormal_blood_vessel0.94315468
133MP0000490_abnormal_crypts_of0.94193796
134MP0003890_abnormal_embryonic-extraembry0.93523078
135MP0001348_abnormal_lacrimal_gland0.93120016
136MP0001845_abnormal_inflammatory_respons0.92958188
137MP0000678_abnormal_parathyroid_gland0.92571672
138MP0003690_abnormal_glial_cell0.91781446
139MP0006054_spinal_hemorrhage0.90761834
140MP0004264_abnormal_extraembryonic_tissu0.90717279
141MP0003077_abnormal_cell_cycle0.90540445
142MP0003091_abnormal_cell_migration0.88389015
143MP0001340_abnormal_eyelid_morphology0.87948715
144MP0003221_abnormal_cardiomyocyte_apopto0.87768089
145MP0003656_abnormal_erythrocyte_physiolo0.86868629
146MP0000569_abnormal_digit_pigmentation0.86537275
147MP0002114_abnormal_axial_skeleton0.86007724
148MP0000465_gastrointestinal_hemorrhage0.85488514
149MP0005621_abnormal_cell_physiology0.85059446
150MP0000003_abnormal_adipose_tissue0.84787215
151MP0005397_hematopoietic_system_phenotyp0.82804668
152MP0001545_abnormal_hematopoietic_system0.82804668
153MP0008770_decreased_survivor_rate0.81892655
154MP0002109_abnormal_limb_morphology0.79074962
155MP0002081_perinatal_lethality0.78387919
156MP0004883_abnormal_blood_vessel0.78006614
157MP0003787_abnormal_imprinting0.77633668
158MP0002128_abnormal_blood_circulation0.76797022
159MP0004858_abnormal_nervous_system0.76753935
160MP0001286_abnormal_eye_development0.76086705
161MP0002933_joint_inflammation0.75058151
162MP0005390_skeleton_phenotype0.74118423
163MP0008469_abnormal_protein_level0.72655267
164MP0003329_amyloid_beta_deposits0.70915718
165MP0001873_stomach_inflammation0.70761586
166MP0002148_abnormal_hypersensitivity_rea0.70652365
167MP0001958_emphysema0.70230305

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.52130663
2Renal duplication (HP:0000075)3.76708781
3Short 4th metacarpal (HP:0010044)3.51642850
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.51642850
5Hyperacusis (HP:0010780)3.48795123
6Recurrent abscess formation (HP:0002722)3.35433207
7Shallow orbits (HP:0000586)3.33354297
8Recurrent bacterial skin infections (HP:0005406)3.29158864
9Cerebral aneurysm (HP:0004944)3.25702850
10Abnormality of the 4th metacarpal (HP:0010012)3.15710722
11Abnormality of macrophages (HP:0004311)3.07514176
12Gastrointestinal infarctions (HP:0005244)3.00069446
13Myositis (HP:0100614)2.97537105
14Recurrent gram-negative bacterial infections (HP:0005420)2.90994587
15Metaphyseal cupping (HP:0003021)2.85272921
16Cellulitis (HP:0100658)2.83570175
17Increased IgE level (HP:0003212)2.81979334
18Orchitis (HP:0100796)2.79778274
19Spontaneous hematomas (HP:0007420)2.79617909
20Obstructive lung disease (HP:0006536)2.62917162
21Chronic obstructive pulmonary disease (HP:0006510)2.62917162
22Lymphangioma (HP:0100764)2.54396475
23Broad thumb (HP:0011304)2.54276773
24Elfin facies (HP:0004428)2.53963052
25Gingivitis (HP:0000230)2.53153180
26Annular pancreas (HP:0001734)2.49768435
27Renovascular hypertension (HP:0100817)2.48616538
28Meningitis (HP:0001287)2.47371413
29Overriding aorta (HP:0002623)2.46898938
30Macroorchidism (HP:0000053)2.45723160
31Turricephaly (HP:0000262)2.43844986
32Mitral valve prolapse (HP:0001634)2.41679118
33Prolonged bleeding time (HP:0003010)2.41235806
34Optic neuritis (HP:0100653)2.41139688
35Retrobulbar optic neuritis (HP:0100654)2.41139688
36Pointed chin (HP:0000307)2.39132808
37Insomnia (HP:0100785)2.38658937
38Arnold-Chiari malformation (HP:0002308)2.37460628
39Pseudobulbar signs (HP:0002200)2.35913107
40Ulnar bowing (HP:0003031)2.35514201
41Midline defect of the nose (HP:0004122)2.33221221
42Obstructive sleep apnea (HP:0002870)2.32049144
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31536764
44Deviation of the hallux (HP:0010051)2.31397390
45Increased nuchal translucency (HP:0010880)2.30363623
46Deep venous thrombosis (HP:0002625)2.29725438
47Recurrent fungal infections (HP:0002841)2.28742764
48Peritonitis (HP:0002586)2.27866054
49Mediastinal lymphadenopathy (HP:0100721)2.27649442
50Segmental peripheral demyelination/remyelination (HP:0003481)2.24225584
51Colitis (HP:0002583)2.22678879
52Gastrointestinal inflammation (HP:0004386)2.21789992
53Hallux valgus (HP:0001822)2.21404685
54Hematochezia (HP:0002573)2.20487687
55Ependymoma (HP:0002888)2.20296515
56Recurrent skin infections (HP:0001581)2.17086952
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.16394473
58Flat acetabular roof (HP:0003180)2.15010233
59Buphthalmos (HP:0000557)2.14693450
60Disproportionate tall stature (HP:0001519)2.13619319
61Polycythemia (HP:0001901)2.12812508
62Abnormality of the peritoneum (HP:0002585)2.12414608
63Abnormality of the fingertips (HP:0001211)2.12374201
64Aortic aneurysm (HP:0004942)2.08588756
65Supernumerary ribs (HP:0005815)2.08370561
66Chest pain (HP:0100749)2.08039112
67Broad toe (HP:0001837)2.07964479
68Trigonocephaly (HP:0000243)2.06951078
69Hemorrhage of the eye (HP:0011885)2.05577723
70Broad phalanges of the hand (HP:0009768)2.04085810
71Bladder diverticulum (HP:0000015)2.02767178
72Arterial thrombosis (HP:0004420)2.02623254
73Inflammation of the large intestine (HP:0002037)2.01627522
74Viral hepatitis (HP:0006562)2.01292506
75Bicuspid aortic valve (HP:0001647)2.01201699
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.00744025
77Asymmetry of the thorax (HP:0001555)2.00623153
78Polygenic inheritance (HP:0010982)2.00496277
79Broad metatarsal (HP:0001783)2.00371480
80Neoplasm of striated muscle (HP:0009728)1.98453675
81Epistaxis (HP:0000421)1.98447239
82Subacute progressive viral hepatitis (HP:0006572)1.97574772
83Deep palmar crease (HP:0006191)1.97552430
84Broad finger (HP:0001500)1.96892278
85Fibrous tissue neoplasm (HP:0012316)1.96728403
86Short phalanx of the thumb (HP:0009660)1.96227033
87Enlarged penis (HP:0000040)1.95791019
88Protrusio acetabuli (HP:0003179)1.95752053
89Bowel diverticulosis (HP:0005222)1.95026477
90Aneurysm (HP:0002617)1.94865220
91Skull defect (HP:0001362)1.94476064
92Short 5th finger (HP:0009237)1.94332225
93Fibroma (HP:0010614)1.93301237
94Syringomyelia (HP:0003396)1.93295964
95Spinal cord lesions (HP:0100561)1.93295964
96Urticaria (HP:0001025)1.93163793
97Hypochromic anemia (HP:0001931)1.93150036
98Broad palm (HP:0001169)1.92458241
99Coronal craniosynostosis (HP:0004440)1.91766338
100Vasculitis (HP:0002633)1.91566464
101Rectal prolapse (HP:0002035)1.91052715
102Astrocytoma (HP:0009592)1.90595214
103Abnormality of the astrocytes (HP:0100707)1.90595214
104Ankyloglossia (HP:0010296)1.90517231
105Slow saccadic eye movements (HP:0000514)1.90267535
106Chronic mucocutaneous candidiasis (HP:0002728)1.90193668
107Recurrent cutaneous fungal infections (HP:0011370)1.90193668
108Abnormality of the diencephalon (HP:0010662)1.89899394
109Skin tags (HP:0010609)1.89587638
110Dilatation of the ascending aorta (HP:0005111)1.88725979
111Recurrent viral infections (HP:0004429)1.88513968
112Malignant gastrointestinal tract tumors (HP:0006749)1.88136771
113Gastrointestinal carcinoma (HP:0002672)1.88136771
114Neoplasm of the heart (HP:0100544)1.87598298
115Gingival bleeding (HP:0000225)1.87347700
116Keratoconjunctivitis sicca (HP:0001097)1.85959019
117Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85754044
118Short 1st metacarpal (HP:0010034)1.85754044
119Back pain (HP:0003418)1.83941332
120Narrow palate (HP:0000189)1.83801105
121Abnormality of the parietal bone (HP:0002696)1.82583695
122Obsessive-compulsive behavior (HP:0000722)1.82468102
123Broad hallux (HP:0010055)1.82453854
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81314401
125Flat cornea (HP:0007720)1.79674678
126Shawl scrotum (HP:0000049)1.79445605
127Osteomyelitis (HP:0002754)1.79396953
128Sacral dimple (HP:0000960)1.79235432
129Abnormal vertebral ossification (HP:0100569)1.78654393
130Basal cell carcinoma (HP:0002671)1.77325964
131Encephalitis (HP:0002383)1.76650638
132Heterotopia (HP:0002282)1.76469837
133Increased density of long bones (HP:0006392)1.74542171
134Achilles tendon contracture (HP:0001771)1.74123366
135Genu recurvatum (HP:0002816)1.73693134
136Broad face (HP:0000283)1.73649896
137Dislocated radial head (HP:0003083)1.73239407
138Proximal placement of thumb (HP:0009623)1.73105490
139Pulmonary embolism (HP:0002204)1.72712927
140Exostoses (HP:0100777)1.72650457
141Broad phalanx (HP:0006009)1.72086220
142Deviation of the thumb (HP:0009603)1.71956709
143Striae distensae (HP:0001065)1.70958647
144Elevated erythrocyte sedimentation rate (HP:0003565)1.70532963
145Long palpebral fissure (HP:0000637)1.70364849
146Camptodactyly of toe (HP:0001836)1.70260707
147Increased connective tissue (HP:0009025)1.69982594
148Increased variability in muscle fiber diameter (HP:0003557)1.69209267
149Abnormal platelet volume (HP:0011876)1.68951247
150High pitched voice (HP:0001620)1.68824253
151Pustule (HP:0200039)1.67415542
152Thin ribs (HP:0000883)1.66707060
153Long toe (HP:0010511)1.66145606
154Hepatoblastoma (HP:0002884)1.66076126
155Bronchomalacia (HP:0002780)1.66044873
156Vertebral fusion (HP:0002948)1.65232949
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.64933535
158Supernumerary bones of the axial skeleton (HP:0009144)1.64761679
159Abnormality of the thoracic spine (HP:0100711)1.64622893
160Thin bony cortex (HP:0002753)1.64260007
161Selective tooth agenesis (HP:0001592)1.63556302
162Rib fusion (HP:0000902)1.62805299
163Urethral obstruction (HP:0000796)1.62419374
164Amyloidosis (HP:0011034)1.62189092
165Abnormality of oral frenula (HP:0000190)1.61337317
166Broad long bones (HP:0005622)1.61230409
167Broad distal phalanx of finger (HP:0009836)1.61017113
168Bladder carcinoma (HP:0002862)1.60560696
169Abnormality of skeletal muscle fiber size (HP:0012084)1.60275775
170Gastrointestinal stroma tumor (HP:0100723)1.57798782
171Abnormality of the lumbar spine (HP:0100712)1.57083622
172Bowel incontinence (HP:0002607)1.57012842
173Menorrhagia (HP:0000132)1.56497487
174Abnormality of the radial head (HP:0003995)1.56030075
175Difficulty running (HP:0009046)1.55781407
176Dysmetric saccades (HP:0000641)1.55329674
177Emphysema (HP:0002097)1.55293510
178Purpura (HP:0000979)1.55069090
179Fatigue (HP:0012378)1.54341286
180Abnormality of the common coagulation pathway (HP:0010990)1.53866911
181Abnormality of cells of the lymphoid lineage (HP:0012140)1.52986830
182Keratoconjunctivitis (HP:0001096)1.52901482
183Episodic fever (HP:0001954)1.52594662
184Onion bulb formation (HP:0003383)1.52588696
185Hypertensive crisis (HP:0100735)1.52492485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.32383798
2MAP3K103.89050294
3PKN23.46491664
4CDK123.35605090
5PRPF4B3.34938561
6RIPK43.29672026
7EEF2K3.27105023
8SMG12.65968576
9PDGFRA2.27476686
10MAP2K32.19557185
11ICK2.16670725
12RIPK12.05331113
13PTK61.97586186
14LATS11.92508462
15IRAK41.75610870
16TYK21.72986314
17EPHB21.70174384
18LATS21.69791146
19PAK41.67181780
20MAP3K131.65319309
21BLK1.62786295
22TYRO31.62254956
23ALK1.60012425
24ERN11.54578504
25LRRK21.52080009
26ZAP701.50199567
27FES1.46918125
28NEK21.45828885
29BMX1.45581010
30KSR21.40502157
31CAMK1G1.38207587
32SIK21.31672138
33CDK61.27008017
34MTOR1.25779945
35PRKD31.23166156
36JAK31.22737659
37TTN1.21834292
38DMPK1.20766465
39BTK1.18764518
40MAP3K11.18161897
41MAP3K141.17937924
42SIK11.16875544
43CAMK1D1.16406159
44SIK31.16277869
45CDC71.15379360
46STK101.14886616
47EPHB11.10125117
48PTK21.10113500
49TLK11.08425797
50DDR21.04508930
51TGFBR21.04339354
52BRD41.03751378
53RET1.02778434
54SCYL21.02653375
55FGFR21.02450936
56TNK21.01963918
57PAK21.01507472
58PDGFRB1.01461611
59CLK11.00954330
60YES11.00102884
61MAP3K80.99900564
62MAP3K30.98743927
63CDK40.94635376
64STK30.93709932
65MAP4K10.93270997
66FGFR10.91836674
67TAOK10.91136403
68ILK0.90337756
69PDPK10.87594902
70GRK60.86248407
71FLT30.83099335
72MAP3K60.82020571
73UHMK10.81910835
74JAK10.79970436
75TGFBR10.76785834
76PRKD20.75886188
77CDK90.75450795
78MAP3K110.75365517
79DYRK1B0.74587210
80PDK10.74286038
81HIPK20.73825191
82SGK30.73710285
83FGR0.71803762
84RPS6KB20.71493961
85TAOK20.71297234
86CDK70.71216237
87SYK0.70858562
88MAP3K90.69222593
89FGFR40.68769118
90KSR10.68661972
91ERBB20.66979989
92CSK0.66788327
93CSF1R0.66276401
94FGFR30.65697447
95MAPK120.63982056
96ITK0.62527687
97TBK10.62360462
98CDC42BPA0.62071745
99PASK0.61561922
100IRAK20.61540701
101MKNK20.61083705
102PRKD10.58747203
103LCK0.57893768
104LYN0.57459948
105PAK60.55198924
106MKNK10.54753025
107IKBKE0.53064974
108MAP3K70.51649549
109PRKCH0.50272563
110MAPK70.50270728
111MARK20.50130691
112CDK20.49595708
113IRAK30.49046681
114MAP2K20.46828839
115RPS6KA10.46560799
116STK110.45486799
117MATK0.45112019
118JAK20.43030786
119CHEK10.42975672
120RPS6KA60.42541384
121HCK0.42462750
122FYN0.41901438
123EGFR0.40865698
124CSNK1E0.39870887
125IRAK10.39833622
126RPS6KA20.39652828
127STK380.38603085
128WNK10.38001791
129GSK3A0.37725986
130AKT10.37680214
131MAP3K20.37551298
132MAPK110.37475673
133CAMKK10.37291758
134CAMK40.37177464
135FER0.37158234
136CSNK1D0.36625913
137NEK10.36428467
138MARK30.36411700
139RPS6KC10.35901433
140RPS6KL10.35901433
141STK40.35322651
142AKT20.35248526

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34865053
2Basal cell carcinoma_Homo sapiens_hsa052172.11857453
3Chronic myeloid leukemia_Homo sapiens_hsa052202.11244659
4Leishmaniasis_Homo sapiens_hsa051401.93613363
5Hippo signaling pathway_Homo sapiens_hsa043901.84906136
6Notch signaling pathway_Homo sapiens_hsa043301.84804130
7Adherens junction_Homo sapiens_hsa045201.78921979
8mTOR signaling pathway_Homo sapiens_hsa041501.75485622
9Proteoglycans in cancer_Homo sapiens_hsa052051.75395156
10Non-small cell lung cancer_Homo sapiens_hsa052231.72813418
11Hedgehog signaling pathway_Homo sapiens_hsa043401.68126643
12Lysine degradation_Homo sapiens_hsa003101.62974255
13MicroRNAs in cancer_Homo sapiens_hsa052061.61791446
14Glioma_Homo sapiens_hsa052141.57928555
15Bladder cancer_Homo sapiens_hsa052191.57715904
16Endometrial cancer_Homo sapiens_hsa052131.55002579
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53434566
18Other glycan degradation_Homo sapiens_hsa005111.52723448
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50953309
20mRNA surveillance pathway_Homo sapiens_hsa030151.47377633
21Staphylococcus aureus infection_Homo sapiens_hsa051501.47336697
22VEGF signaling pathway_Homo sapiens_hsa043701.46965492
23Colorectal cancer_Homo sapiens_hsa052101.46941267
24Dorso-ventral axis formation_Homo sapiens_hsa043201.46557181
25Renal cell carcinoma_Homo sapiens_hsa052111.41825141
26Focal adhesion_Homo sapiens_hsa045101.40740928
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40313070
28Thyroid cancer_Homo sapiens_hsa052161.40025849
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35856452
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.35187637
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33094060
32Estrogen signaling pathway_Homo sapiens_hsa049151.30948927
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30613617
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30460664
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30199799
36Measles_Homo sapiens_hsa051621.29742420
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.28347916
38Small cell lung cancer_Homo sapiens_hsa052221.28306636
39Tuberculosis_Homo sapiens_hsa051521.27730991
40Wnt signaling pathway_Homo sapiens_hsa043101.26821379
41Melanogenesis_Homo sapiens_hsa049161.25973878
42Acute myeloid leukemia_Homo sapiens_hsa052211.23579305
43Pancreatic cancer_Homo sapiens_hsa052121.22680842
44Influenza A_Homo sapiens_hsa051641.22353239
45TGF-beta signaling pathway_Homo sapiens_hsa043501.19316275
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17834872
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.15818083
48Prostate cancer_Homo sapiens_hsa052151.14943019
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.11712925
50HTLV-I infection_Homo sapiens_hsa051661.10760326
51Pathways in cancer_Homo sapiens_hsa052001.10520025
52Herpes simplex infection_Homo sapiens_hsa051681.10138789
53Spliceosome_Homo sapiens_hsa030401.08939069
54Hepatitis C_Homo sapiens_hsa051601.08585602
55B cell receptor signaling pathway_Homo sapiens_hsa046621.08465220
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08350168
57Rap1 signaling pathway_Homo sapiens_hsa040151.08269029
58Malaria_Homo sapiens_hsa051441.07978292
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07727101
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03965579
61Tight junction_Homo sapiens_hsa045301.02763856
62Insulin resistance_Homo sapiens_hsa049311.01583417
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98024720
64Platelet activation_Homo sapiens_hsa046110.97200124
65TNF signaling pathway_Homo sapiens_hsa046680.97132475
66Type II diabetes mellitus_Homo sapiens_hsa049300.96865432
67Axon guidance_Homo sapiens_hsa043600.96567313
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95648603
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95616531
70Apoptosis_Homo sapiens_hsa042100.94666235
71Oocyte meiosis_Homo sapiens_hsa041140.94269602
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93971160
73Insulin signaling pathway_Homo sapiens_hsa049100.93870193
74Primary immunodeficiency_Homo sapiens_hsa053400.92886212
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91626587
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91388568
77Cell cycle_Homo sapiens_hsa041100.91342811
78ErbB signaling pathway_Homo sapiens_hsa040120.90366095
79Gap junction_Homo sapiens_hsa045400.90296736
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.88789003
81Nitrogen metabolism_Homo sapiens_hsa009100.88564661
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88238485
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.88109363
84Viral carcinogenesis_Homo sapiens_hsa052030.87952729
85Viral myocarditis_Homo sapiens_hsa054160.87877163
86ECM-receptor interaction_Homo sapiens_hsa045120.86699276
87Inositol phosphate metabolism_Homo sapiens_hsa005620.86278381
88Amoebiasis_Homo sapiens_hsa051460.86153161
89Shigellosis_Homo sapiens_hsa051310.85757423
90AMPK signaling pathway_Homo sapiens_hsa041520.85399707
91Prolactin signaling pathway_Homo sapiens_hsa049170.82771830
92Graft-versus-host disease_Homo sapiens_hsa053320.80996723
93Prion diseases_Homo sapiens_hsa050200.80675969
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79955069
95Endocytosis_Homo sapiens_hsa041440.79515788
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79377626
97Allograft rejection_Homo sapiens_hsa053300.79008603
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78066327
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.77703673
100GnRH signaling pathway_Homo sapiens_hsa049120.77247761
101FoxO signaling pathway_Homo sapiens_hsa040680.76886216
102HIF-1 signaling pathway_Homo sapiens_hsa040660.76326179
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75372083
104Hepatitis B_Homo sapiens_hsa051610.75354386
105Autoimmune thyroid disease_Homo sapiens_hsa053200.74315654
106Melanoma_Homo sapiens_hsa052180.73471651
107MAPK signaling pathway_Homo sapiens_hsa040100.72396913
108Osteoclast differentiation_Homo sapiens_hsa043800.71863709
109Long-term potentiation_Homo sapiens_hsa047200.70488496
110Hematopoietic cell lineage_Homo sapiens_hsa046400.70473022
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70110651
112Choline metabolism in cancer_Homo sapiens_hsa052310.68753983
113Dilated cardiomyopathy_Homo sapiens_hsa054140.68521810
114T cell receptor signaling pathway_Homo sapiens_hsa046600.66840543
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66747990
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66480951
117Salmonella infection_Homo sapiens_hsa051320.64991104
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64520724
119Glucagon signaling pathway_Homo sapiens_hsa049220.63349749
120Legionellosis_Homo sapiens_hsa051340.63088491
121RNA transport_Homo sapiens_hsa030130.62887529
122African trypanosomiasis_Homo sapiens_hsa051430.62599188
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62297952
124Toxoplasmosis_Homo sapiens_hsa051450.61113993
125Chemokine signaling pathway_Homo sapiens_hsa040620.59131751
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58959580
127Epstein-Barr virus infection_Homo sapiens_hsa051690.58198010
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58076961
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58015446
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57919594
131Pertussis_Homo sapiens_hsa051330.57470741
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.54505372
133Oxytocin signaling pathway_Homo sapiens_hsa049210.54390106
134Alcoholism_Homo sapiens_hsa050340.53518465
135Antigen processing and presentation_Homo sapiens_hsa046120.53417371

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