PBX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.03435929
2cilium or flagellum-dependent cell motility (GO:0001539)6.82725333
3cilium movement (GO:0003341)6.09733026
4epithelial cilium movement (GO:0003351)6.01073801
5motile cilium assembly (GO:0044458)5.76286188
6tolerance induction (GO:0002507)5.72019723
7regulation of regulatory T cell differentiation (GO:0045589)5.61918777
8DNA deamination (GO:0045006)5.59889771
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.53690208
10regulation of isotype switching to IgG isotypes (GO:0048302)5.51928631
11negative T cell selection (GO:0043383)5.42758878
12sperm motility (GO:0030317)5.39390542
13acrosome reaction (GO:0007340)5.28637108
14regulation of chronic inflammatory response (GO:0002676)5.13349256
15negative thymic T cell selection (GO:0045060)5.10312485
16regulation of cilium movement (GO:0003352)5.09472389
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.02922140
18fusion of sperm to egg plasma membrane (GO:0007342)4.93558004
19negative regulation of cell killing (GO:0031342)4.92513948
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.92513948
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.83016700
22sperm-egg recognition (GO:0035036)4.72707116
23cellular response to interleukin-15 (GO:0071350)4.62667543
24T cell migration (GO:0072678)4.61211592
25binding of sperm to zona pellucida (GO:0007339)4.58788514
26GTP biosynthetic process (GO:0006183)4.54551486
27positive regulation of gamma-delta T cell activation (GO:0046645)4.54196186
28regulation of T cell tolerance induction (GO:0002664)4.50028298
29spermatid development (GO:0007286)4.39927624
30response to interleukin-15 (GO:0070672)4.36170957
31acrosome assembly (GO:0001675)4.36033471
32piRNA metabolic process (GO:0034587)4.33634779
33cell wall macromolecule metabolic process (GO:0044036)4.31588447
34cell wall macromolecule catabolic process (GO:0016998)4.31588447
35regulation of alpha-beta T cell proliferation (GO:0046640)4.30787253
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.27277696
37NIK/NF-kappaB signaling (GO:0038061)4.23850238
38UTP biosynthetic process (GO:0006228)4.17413204
39axoneme assembly (GO:0035082)4.16855466
40cell-cell recognition (GO:0009988)4.16587552
41thymic T cell selection (GO:0045061)4.13279312
42positive regulation of tolerance induction (GO:0002645)4.12776327
43T cell selection (GO:0045058)4.04940982
44positive regulation of alpha-beta T cell proliferation (GO:0046641)4.04287982
45cytidine deamination (GO:0009972)4.03997302
46cytidine metabolic process (GO:0046087)4.03997302
47cytidine catabolic process (GO:0006216)4.03997302
48telomere maintenance via semi-conservative replication (GO:0032201)4.03020248
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.02066106
50DNA replication initiation (GO:0006270)4.01866545
51DNA strand elongation involved in DNA replication (GO:0006271)4.00438784
52positive T cell selection (GO:0043368)3.99785530
53ribosomal small subunit assembly (GO:0000028)3.99670207
54male meiosis (GO:0007140)3.97412306
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.92924310
56regulation of interleukin-2 biosynthetic process (GO:0045076)3.91097439
57positive regulation of isotype switching (GO:0045830)3.89677290
58positive regulation of interleukin-2 production (GO:0032743)3.88755485
59protein polyglutamylation (GO:0018095)3.87293505
60positive regulation of interleukin-17 production (GO:0032740)3.86385692
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86310961
62microtubule depolymerization (GO:0007019)3.86126828
63pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.81002717
64DNA strand elongation (GO:0022616)3.80382987
65CTP biosynthetic process (GO:0006241)3.79131646
66CTP metabolic process (GO:0046036)3.79131646
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.77923383
68multicellular organism reproduction (GO:0032504)3.76467683
69dendritic cell chemotaxis (GO:0002407)3.76452276
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.75793944
71guanosine-containing compound biosynthetic process (GO:1901070)3.72636534
72plasma membrane fusion (GO:0045026)3.72501514
73UTP metabolic process (GO:0046051)3.71849045
74interferon-gamma production (GO:0032609)3.70961389
75ventricular system development (GO:0021591)3.64156063
76viral transcription (GO:0019083)3.64075567
77regulation of B cell receptor signaling pathway (GO:0050855)3.63773613
78myeloid dendritic cell differentiation (GO:0043011)3.62564814
79positive regulation of DNA recombination (GO:0045911)3.60910108
80regulation of tolerance induction (GO:0002643)3.58287870
81pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.56924896
82synaptonemal complex organization (GO:0070193)3.56397405
83positive regulation of T cell differentiation in thymus (GO:0033089)3.53971391
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.50485002
85translational termination (GO:0006415)3.50164238
86regulation of gamma-delta T cell activation (GO:0046643)3.48966947
87regulation of isotype switching (GO:0045191)3.47182457
88regulation of gamma-delta T cell differentiation (GO:0045586)3.44219146
89regulation of T cell receptor signaling pathway (GO:0050856)3.43119506
90signal complex assembly (GO:0007172)3.42249383
91regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.41755960
92telomere maintenance via recombination (GO:0000722)3.41750776
93T-helper cell differentiation (GO:0042093)3.40846346
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.40846346
95alpha-beta T cell differentiation (GO:0046632)3.39579181
96regulation of immunoglobulin secretion (GO:0051023)3.36873163
97regulation of natural killer cell mediated immunity (GO:0002715)3.33333931
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33333931
99alpha-beta T cell differentiation involved in immune response (GO:0002293)3.31538260
100alpha-beta T cell activation involved in immune response (GO:0002287)3.31538260
101T cell differentiation involved in immune response (GO:0002292)3.31538260
102T cell receptor signaling pathway (GO:0050852)3.30545986
103activated T cell proliferation (GO:0050798)3.29104342
104negative regulation of T cell mediated immunity (GO:0002710)3.28964104
105leukocyte aggregation (GO:0070486)3.28666066
106granulocyte activation (GO:0036230)3.26965424
107pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.26532295
108positive thymic T cell selection (GO:0045059)3.26512493
109nucleoside diphosphate phosphorylation (GO:0006165)3.25630858
110male meiosis I (GO:0007141)3.22949762
111platelet dense granule organization (GO:0060155)3.22850090
112protein localization to cilium (GO:0061512)3.22280623
113DNA methylation involved in gamete generation (GO:0043046)3.22104205
114translational elongation (GO:0006414)3.21925733
115synaptonemal complex assembly (GO:0007130)3.21360382
116intraciliary transport (GO:0042073)3.20854940
117myeloid dendritic cell activation (GO:0001773)3.20839915
118establishment of integrated proviral latency (GO:0075713)3.20489953
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19758717
120histone H2A acetylation (GO:0043968)3.18214152
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17981850
122viral mRNA export from host cell nucleus (GO:0046784)3.15331589
123regulation of interleukin-2 production (GO:0032663)3.14318833
124histone exchange (GO:0043486)3.13503543
125neutrophil activation (GO:0042119)3.12484692
126telomere maintenance via telomere lengthening (GO:0010833)3.11909596
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11128203
128alpha-beta T cell activation (GO:0046631)3.10565255
129mitotic recombination (GO:0006312)3.09961601
130negative regulation by host of viral transcription (GO:0043922)3.09866542
131negative regulation of T cell apoptotic process (GO:0070233)3.09364206
132positive regulation of granulocyte differentiation (GO:0030854)3.08976707
133meiosis I (GO:0007127)3.08918436
134DNA ligation (GO:0006266)3.08290848
135regulation of interleukin-12 biosynthetic process (GO:0045075)3.06671012
136positive regulation of T cell cytokine production (GO:0002726)3.06018534
137dendritic cell migration (GO:0036336)3.05714554
138single fertilization (GO:0007338)3.05637555
139chromatin remodeling at centromere (GO:0031055)3.05559044
140positive regulation of natural killer cell mediated immunity (GO:0002717)3.04226071
141positive regulation of interleukin-4 production (GO:0032753)3.04218031
142B cell homeostasis (GO:0001782)3.03661108
143CENP-A containing nucleosome assembly (GO:0034080)3.02577268
144negative regulation of alpha-beta T cell activation (GO:0046636)3.01962574
145positive regulation of calcium-mediated signaling (GO:0050850)3.01466856
146reproduction (GO:0000003)2.99881135
147negative regulation of T-helper cell differentiation (GO:0045623)2.99726312
148negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99726312
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99209824
150positive regulation of B cell mediated immunity (GO:0002714)2.99181472
151positive regulation of immunoglobulin mediated immune response (GO:0002891)2.99181472
152regulation of alpha-beta T cell activation (GO:0046634)2.98652171
153negative regulation of B cell activation (GO:0050869)2.96687791
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96308706
155cotranslational protein targeting to membrane (GO:0006613)2.95933252
156antigen receptor-mediated signaling pathway (GO:0050851)2.95811423
157cellular protein complex disassembly (GO:0043624)2.94869051
158chemokine-mediated signaling pathway (GO:0070098)2.94521700
159microtubule severing (GO:0051013)2.94052209
160nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93572950
161spliceosomal snRNP assembly (GO:0000387)2.92683018
162meiotic nuclear division (GO:0007126)2.92560668
163sequestering of actin monomers (GO:0042989)2.91344170
164pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90867423
165regulation of B cell differentiation (GO:0045577)2.90688174
166protein targeting to ER (GO:0045047)2.90184341
167regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88622698
168regulation of interleukin-4 production (GO:0032673)2.87590840
169pyrimidine nucleotide catabolic process (GO:0006244)2.86562721
170spermatid nucleus differentiation (GO:0007289)2.86334325
171regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.86145033
172regulation of microtubule-based movement (GO:0060632)2.85251422
173negative regulation of lymphocyte mediated immunity (GO:0002707)2.84174380
174intra-S DNA damage checkpoint (GO:0031573)2.84045816
175negative regulation of leukocyte mediated immunity (GO:0002704)2.83856634
176cilium organization (GO:0044782)2.82860192
177male gamete generation (GO:0048232)2.82756041
178T cell homeostasis (GO:0043029)2.82718342
179spermatogenesis (GO:0007283)2.82474690
180regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82258966
181CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.82091158
182ribosomal small subunit biogenesis (GO:0042274)2.82000152
183protein complex disassembly (GO:0043241)2.81227145
184natural killer cell differentiation (GO:0001779)2.80756030
185nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78618446
186regulation of cell killing (GO:0031341)2.78467502
187DNA replication-independent nucleosome organization (GO:0034724)2.77770603
188DNA replication-independent nucleosome assembly (GO:0006336)2.77770603
189positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.77385242
190left/right axis specification (GO:0070986)2.77326620
191protein localization to endoplasmic reticulum (GO:0070972)2.77048069
192translesion synthesis (GO:0019985)2.75939792
193protein localization to chromosome, centromeric region (GO:0071459)2.75357519
194cilium assembly (GO:0042384)2.73682055
195ribosomal large subunit biogenesis (GO:0042273)2.73674595
196maturation of SSU-rRNA (GO:0030490)2.71482091
197establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71131731
198proteasome assembly (GO:0043248)2.69098060
199pyrimidine nucleotide biosynthetic process (GO:0006221)2.68963834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.29887636
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.07527735
3E2F7_22180533_ChIP-Seq_HELA_Human5.87828772
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.83755790
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.19165014
6RUNX_20019798_ChIP-Seq_JUKART_Human3.35538353
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.18394088
8MYB_26560356_Chip-Seq_TH2_Human3.07496490
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06895255
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96243744
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84413081
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79359972
13EZH2_22144423_ChIP-Seq_EOC_Human2.76371035
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76238271
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75163775
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72166957
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70199111
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.67491920
19* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62840888
20MAF_26560356_Chip-Seq_TH1_Human2.61038934
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.58976939
22UTX_26944678_Chip-Seq_JUKART_Human2.58857339
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53786263
24MAF_26560356_Chip-Seq_TH2_Human2.52698354
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49531209
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46668134
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43125028
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38589667
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.37089171
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.31973298
31MYB_26560356_Chip-Seq_TH1_Human2.27885046
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.26843423
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24361187
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18744434
35* GATA3_27048872_Chip-Seq_THYMUS_Human2.15405690
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14847580
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14718587
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12459595
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01847202
40* VDR_23849224_ChIP-Seq_CD4+_Human1.97706259
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97459014
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94377570
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93782819
44XRN2_22483619_ChIP-Seq_HELA_Human1.92324823
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81245765
46FOXP3_21729870_ChIP-Seq_TREG_Human1.80978776
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80741074
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79575839
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78779257
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77217908
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75477052
52TTF2_22483619_ChIP-Seq_HELA_Human1.73706064
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70709793
54GABP_19822575_ChIP-Seq_HepG2_Human1.68857054
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.68798936
56KDM2B_26808549_Chip-Seq_DND41_Human1.67441171
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67027618
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.63228386
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62922779
60GATA3_26560356_Chip-Seq_TH2_Human1.62922668
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.61802565
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.61343791
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.61012673
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58680591
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.57881245
66DCP1A_22483619_ChIP-Seq_HELA_Human1.56747247
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.55655376
68* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55129614
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.52236718
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50882714
71SPI1_23547873_ChIP-Seq_NB4_Human1.49345703
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47865753
73SCL_19346495_ChIP-Seq_HPC-7_Human1.45927844
74BCL6_27268052_Chip-Seq_Bcells_Human1.44715654
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.44602041
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43943609
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43938647
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43727751
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38004167
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37165790
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35748998
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35642912
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35359871
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31167635
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29567967
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.27106875
87TCF7_22412390_ChIP-Seq_EML_Mouse1.26233814
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.25866550
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25700577
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25272743
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24050877
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.23589145
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23355853
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19232379
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.17168811
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16691505
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16236863
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15504083
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14761621
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14508501
101IRF1_19129219_ChIP-ChIP_H3396_Human1.14482241
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13921844
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13270236
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12187773
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11826224
106VDR_24763502_ChIP-Seq_THP-1_Human1.11798609
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10411654
108* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08961742
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07667218
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07662201
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07526103
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06385013
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05549290
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04828848
115* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04648475
116MYC_18940864_ChIP-ChIP_HL60_Human1.03874343
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03347042
118ELK3_25401928_ChIP-Seq_HUVEC_Human1.02306773
119SPI1_23127762_ChIP-Seq_K562_Human1.02263111
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02046298
121* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01870471
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01526691
123NCOR1_26117541_ChIP-Seq_K562_Human1.01383686
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01073811
125CIITA_25753668_ChIP-Seq_RAJI_Human1.00751555
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99963494
127BCOR_27268052_Chip-Seq_Bcells_Human0.99527370
128SOX2_22085726_ChIP-Seq_NPCs_Mouse0.98256385
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97830104
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96205294
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94793596
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94631979
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94482749
134MYC_22102868_ChIP-Seq_BL_Human0.94423680
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94247612
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94094172
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94033950
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93240039
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93152199
140GATA3_21867929_ChIP-Seq_CD8_Mouse0.90764999
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90064032
142VDR_21846776_ChIP-Seq_THP-1_Human0.89466287
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88980415
144PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88234470
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87458144
146P68_20966046_ChIP-Seq_HELA_Human0.87415335
147ELK1_19687146_ChIP-ChIP_HELA_Human0.87213523
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87156278
149KDM5A_27292631_Chip-Seq_BREAST_Human0.87085242
150RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86313112
151WDR5_24793694_ChIP-Seq_LNCAP_Human0.85732742
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85509685
153PHF8_20622854_ChIP-Seq_HELA_Human0.85453170
154RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85305770
155TET1_21451524_ChIP-Seq_MESCs_Mouse0.83400704
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83375042
157STAT1_20625510_ChIP-Seq_HELA_Human0.81622094
158REST_21632747_ChIP-Seq_MESCs_Mouse0.81201148
159SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81076131
160ELF1_20517297_ChIP-Seq_JURKAT_Human0.79754415
161CTCF_26484167_Chip-Seq_Bcells_Mouse0.79537579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.17629815
2MP0008877_abnormal_DNA_methylation3.59232662
3MP0009333_abnormal_splenocyte_physiolog3.22509510
4MP0003436_decreased_susceptibility_to3.21543230
5MP0010094_abnormal_chromosome_stability3.18729567
6MP0001835_abnormal_antigen_presentation3.16523795
7MP0005000_abnormal_immune_tolerance3.16154128
8MP0003698_abnormal_male_reproductive3.07422553
9MP0001800_abnormal_humoral_immune3.04995385
10MP0001929_abnormal_gametogenesis3.02668552
11MP0002148_abnormal_hypersensitivity_rea3.00923338
12MP0008058_abnormal_DNA_repair2.95969884
13MP0008057_abnormal_DNA_replication2.83906562
14MP0001790_abnormal_immune_system2.69173677
15MP0005387_immune_system_phenotype2.69173677
16MP0002396_abnormal_hematopoietic_system2.66734419
17MP0002723_abnormal_immune_serum2.66447688
18MP0002420_abnormal_adaptive_immunity2.44760382
19MP0001819_abnormal_immune_cell2.38120447
20MP0002210_abnormal_sex_determination2.38052367
21MP0003111_abnormal_nucleus_morphology2.34897436
22MP0001984_abnormal_olfaction2.31600246
23MP0000465_gastrointestinal_hemorrhage2.30606455
24MP0003880_abnormal_central_pattern2.28673253
25MP0002452_abnormal_antigen_presenting2.27882441
26MP0003693_abnormal_embryo_hatching2.27580786
27MP0003300_gastrointestinal_ulcer2.21189993
28MP0002277_abnormal_respiratory_mucosa2.18506757
29MP0002405_respiratory_system_inflammati2.17006497
30MP0009785_altered_susceptibility_to2.16137873
31MP0005025_abnormal_response_to2.10384172
32MP0005174_abnormal_tail_pigmentation2.06676387
33MP0002653_abnormal_ependyma_morphology2.06376639
34MP0003077_abnormal_cell_cycle2.02315304
35MP0010155_abnormal_intestine_physiology2.01210357
36MP0001145_abnormal_male_reproductive1.99919938
37MP0002822_catalepsy1.99635484
38MP0005075_abnormal_melanosome_morpholog1.98042877
39MP0005310_abnormal_salivary_gland1.97072141
40MP0003724_increased_susceptibility_to1.96176660
41MP0006276_abnormal_autonomic_nervous1.89662033
42MP0008007_abnormal_cellular_replicative1.89578182
43MP0002160_abnormal_reproductive_system1.88727879
44MP0006082_CNS_inflammation1.85348057
45MP0005464_abnormal_platelet_physiology1.81806867
46MP0004957_abnormal_blastocyst_morpholog1.81330745
47MP0008995_early_reproductive_senescence1.81289288
48MP0006292_abnormal_olfactory_placode1.81121631
49MP0003786_premature_aging1.80285262
50MP0001529_abnormal_vocalization1.75140004
51MP0004947_skin_inflammation1.74737424
52MP0002419_abnormal_innate_immunity1.74484361
53MP0002161_abnormal_fertility/fecundity1.74193217
54MP0001853_heart_inflammation1.72652069
55MP0005397_hematopoietic_system_phenotyp1.71786143
56MP0001545_abnormal_hematopoietic_system1.71786143
57MP0001188_hyperpigmentation1.71683670
58MP0000653_abnormal_sex_gland1.71300033
59MP0004808_abnormal_hematopoietic_stem1.69202154
60MP0004510_myositis1.66754125
61MP0000604_amyloidosis1.65082672
62MP0004133_heterotaxia1.64971079
63MP0003303_peritoneal_inflammation1.61882735
64MP0001845_abnormal_inflammatory_respons1.56037964
65MP0003763_abnormal_thymus_physiology1.51692972
66MP0009379_abnormal_foot_pigmentation1.46791674
67MP0002254_reproductive_system_inflammat1.39170967
68MP0008932_abnormal_embryonic_tissue1.35025206
69MP0003136_yellow_coat_color1.28191402
70MP0001873_stomach_inflammation1.26677670
71MP0002138_abnormal_hepatobiliary_system1.26468944
72MP0001968_abnormal_touch/_nociception1.26439357
73MP0009764_decreased_sensitivity_to1.26216299
74MP0001905_abnormal_dopamine_level1.24587686
75MP0002163_abnormal_gland_morphology1.22519823
76MP0002095_abnormal_skin_pigmentation1.19945076
77MP0000490_abnormal_crypts_of1.18489871
78MP0001348_abnormal_lacrimal_gland1.17891038
79MP0005423_abnormal_somatic_nervous1.17131253
80MP0006035_abnormal_mitochondrial_morpho1.14812096
81MP0005646_abnormal_pituitary_gland1.14242967
82MP0001919_abnormal_reproductive_system1.13290875
83MP0002398_abnormal_bone_marrow1.12953669
84MP0004381_abnormal_hair_follicle1.09410758
85MP0002638_abnormal_pupillary_reflex1.08341653
86MP0002928_abnormal_bile_duct1.08302843
87MP0002736_abnormal_nociception_after1.08250667
88MP0006036_abnormal_mitochondrial_physio1.06951629
89MP0001533_abnormal_skeleton_physiology1.06269209
90MP0003315_abnormal_perineum_morphology1.06066936
91MP0000703_abnormal_thymus_morphology1.05445819
92MP0005389_reproductive_system_phenotype1.05202217
93MP0004859_abnormal_synaptic_plasticity1.04512536
94MP0002102_abnormal_ear_morphology1.03120297
95MP0005409_darkened_coat_color1.00825588
96MP0004142_abnormal_muscle_tone1.00367105
97MP0005645_abnormal_hypothalamus_physiol0.97494316
98MP0003121_genomic_imprinting0.96709124
99MP0000358_abnormal_cell_content/0.96000459
100MP0005394_taste/olfaction_phenotype0.95878506
101MP0005499_abnormal_olfactory_system0.95878506
102MP0003635_abnormal_synaptic_transmissio0.95725752
103MP0000313_abnormal_cell_death0.94785665
104MP0009765_abnormal_xenobiotic_induced0.94533909
105MP0002272_abnormal_nervous_system0.93055949
106MP0006072_abnormal_retinal_apoptosis0.91740859
107MP0000015_abnormal_ear_pigmentation0.90627343
108MP0009745_abnormal_behavioral_response0.90566729
109MP0005671_abnormal_response_to0.89926783
110MP0008789_abnormal_olfactory_epithelium0.89870924
111MP0002132_abnormal_respiratory_system0.89007248
112MP0002019_abnormal_tumor_incidence0.88956614
113MP0008961_abnormal_basal_metabolism0.88824528
114MP0001986_abnormal_taste_sensitivity0.88073560
115MP0008469_abnormal_protein_level0.86867779
116MP0000631_abnormal_neuroendocrine_gland0.86030586
117MP0004147_increased_porphyrin_level0.85377690
118MP0008872_abnormal_physiological_respon0.85364675
119MP0000689_abnormal_spleen_morphology0.84893308
120MP0002557_abnormal_social/conspecific_i0.84384026
121MP0001663_abnormal_digestive_system0.84193757
122MP0003329_amyloid_beta_deposits0.83483037
123MP0002572_abnormal_emotion/affect_behav0.83038367
124MP0002722_abnormal_immune_system0.82848936
125MP0002938_white_spotting0.81221655
126MP0005379_endocrine/exocrine_gland_phen0.80685612
127MP0002429_abnormal_blood_cell0.80471540
128MP0000350_abnormal_cell_proliferation0.79228645
129MP0003448_altered_tumor_morphology0.78392140
130MP0000858_altered_metastatic_potential0.77305559
131MP0001851_eye_inflammation0.77135606
132MP0002063_abnormal_learning/memory/cond0.77031212
133MP0004811_abnormal_neuron_physiology0.76064730
134MP0000716_abnormal_immune_system0.74259764
135MP0004742_abnormal_vestibular_system0.74040270
136MP0009046_muscle_twitch0.73266342
137MP0003879_abnormal_hair_cell0.72989409
138MP0003943_abnormal_hepatobiliary_system0.72313161
139MP0008260_abnormal_autophagy0.72292452
140MP0000685_abnormal_immune_system0.71569198
141MP0002933_joint_inflammation0.71437430
142MP0002184_abnormal_innervation0.69043692
143MP0009763_increased_sensitivity_to0.66847922
144MP0008004_abnormal_stomach_pH0.66337645
145MP0001502_abnormal_circadian_rhythm0.65971417
146MP0002998_abnormal_bone_remodeling0.65612931
147MP0003866_abnormal_defecation0.65508546
148MP0002067_abnormal_sensory_capabilities0.64818237
149MP0001486_abnormal_startle_reflex0.64730985
150MP0001542_abnormal_bone_strength0.64728108
151MP0003122_maternal_imprinting0.63988283
152MP0002064_seizures0.63338048
153MP0003787_abnormal_imprinting0.62633460
154MP0002089_abnormal_postnatal_growth/wei0.62028813
155MP0002735_abnormal_chemical_nociception0.61652420
156MP0008874_decreased_physiological_sensi0.60342849
157MP0001346_abnormal_lacrimal_gland0.59189156
158MP0003221_abnormal_cardiomyocyte_apopto0.55074256
159MP0005058_abnormal_lysosome_morphology0.48556568
160MP0003795_abnormal_bone_structure0.46598711
161MP0000343_altered_response_to0.46149333
162MP0000372_irregular_coat_pigmentation0.42539665
163MP0000249_abnormal_blood_vessel0.42531438
164MP0005381_digestive/alimentary_phenotyp0.39512898
165MP0005390_skeleton_phenotype0.37421888
166MP0003938_abnormal_ear_development0.37299915

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.27171841
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.35112402
3Absent/shortened dynein arms (HP:0200106)7.35112402
4Abnormal respiratory motile cilium physiology (HP:0012261)7.12723626
5Abnormal respiratory motile cilium morphology (HP:0005938)6.67632861
6Abnormal respiratory epithelium morphology (HP:0012253)6.67632861
7Abnormal ciliary motility (HP:0012262)6.27066999
8Rhinitis (HP:0012384)5.86154743
9Stomatitis (HP:0010280)5.56669901
10T lymphocytopenia (HP:0005403)5.04034808
11Abnormality of T cell number (HP:0011839)4.68030866
12IgG deficiency (HP:0004315)4.57866632
13Chronic bronchitis (HP:0004469)4.56047202
14Abnormal number of erythroid precursors (HP:0012131)4.46183457
15Abnormality of cells of the erythroid lineage (HP:0012130)4.39111542
16Increased IgM level (HP:0003496)4.37134823
17Nasal polyposis (HP:0100582)4.30001408
18Infertility (HP:0000789)4.01959607
19Elevated erythrocyte sedimentation rate (HP:0003565)4.01585400
20Abnormality of macrophages (HP:0004311)3.95077580
21Abnormality of T cells (HP:0002843)3.91604579
22IgM deficiency (HP:0002850)3.88977245
23Mediastinal lymphadenopathy (HP:0100721)3.75046518
24Bronchiectasis (HP:0002110)3.68747198
25Severe combined immunodeficiency (HP:0004430)3.62061622
26True hermaphroditism (HP:0010459)3.58800996
27Pancreatic fibrosis (HP:0100732)3.57889620
28Lymphopenia (HP:0001888)3.56449352
29Abnormality of the nasal mucosa (HP:0000433)3.43339315
30Split foot (HP:0001839)3.39675935
31Combined immunodeficiency (HP:0005387)3.33650297
32Autoimmune hemolytic anemia (HP:0001890)3.31565863
33Supernumerary spleens (HP:0009799)3.30779935
34Eczematoid dermatitis (HP:0000976)3.27969267
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.27217739
36Chronic diarrhea (HP:0002028)3.22214671
37Tubulointerstitial nephritis (HP:0001970)3.16226069
38IgA deficiency (HP:0002720)3.12967401
39Bronchitis (HP:0012387)3.11680285
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.09533268
41Recurrent bacterial skin infections (HP:0005406)3.01094037
42Medial flaring of the eyebrow (HP:0010747)3.00962289
43Prolonged bleeding time (HP:0003010)2.99039599
44Aplastic anemia (HP:0001915)2.98312107
45Pustule (HP:0200039)2.98052016
46Abnormality of eosinophils (HP:0001879)2.93364753
47Oral leukoplakia (HP:0002745)2.89629790
48Panhypogammaglobulinemia (HP:0003139)2.88758511
49Encephalitis (HP:0002383)2.87066731
50Nephronophthisis (HP:0000090)2.84152799
51Pancreatic cysts (HP:0001737)2.82742493
52Molar tooth sign on MRI (HP:0002419)2.82179491
53Abnormality of midbrain morphology (HP:0002418)2.82179491
54Recurrent fungal infections (HP:0002841)2.78974026
55Cutaneous melanoma (HP:0012056)2.76098757
56Pulmonary infiltrates (HP:0002113)2.71145817
57Abnormality of T cell physiology (HP:0011840)2.69702790
58Basal cell carcinoma (HP:0002671)2.68170179
59Obstructive lung disease (HP:0006536)2.66598892
60Chronic obstructive pulmonary disease (HP:0006510)2.66598892
61Myositis (HP:0100614)2.66411560
62Meningitis (HP:0001287)2.60216362
63Vasculitis (HP:0002633)2.58807828
64Optic neuritis (HP:0100653)2.56466748
65Retrobulbar optic neuritis (HP:0100654)2.56466748
66Recurrent viral infections (HP:0004429)2.55196143
67Reticulocytopenia (HP:0001896)2.54740716
68Gait imbalance (HP:0002141)2.53982650
69Eosinophilia (HP:0001880)2.53973249
70Joint swelling (HP:0001386)2.52855987
71Occipital encephalocele (HP:0002085)2.51255126
72Congenital primary aphakia (HP:0007707)2.48767961
73Recurrent abscess formation (HP:0002722)2.48529009
74Granulocytopenia (HP:0001913)2.47369400
75Recurrent sinusitis (HP:0011108)2.46484267
76Male infertility (HP:0003251)2.44217276
77Asplenia (HP:0001746)2.43518848
78Leukocytosis (HP:0001974)2.42702559
79Postaxial foot polydactyly (HP:0001830)2.41732570
80Acute necrotizing encephalopathy (HP:0006965)2.40818336
81Chronic sinusitis (HP:0011109)2.40625179
82Alveolar cell carcinoma (HP:0006519)2.40529186
83Purpura (HP:0000979)2.39628575
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35533342
85Abnormal biliary tract physiology (HP:0012439)2.32086161
86Bile duct proliferation (HP:0001408)2.32086161
87Anencephaly (HP:0002323)2.27919613
88Abnormality of the heme biosynthetic pathway (HP:0010472)2.25220207
89Hypoplasia of the thymus (HP:0000778)2.25070749
90Nephrogenic diabetes insipidus (HP:0009806)2.24240657
91Orchitis (HP:0100796)2.20246322
92Broad distal phalanx of finger (HP:0009836)2.18890360
93Chronic otitis media (HP:0000389)2.18685335
94Lymphoma (HP:0002665)2.18635265
95Severe visual impairment (HP:0001141)2.17703928
96Hypergammaglobulinemia (HP:0010702)2.16396519
97Upper limb muscle weakness (HP:0003484)2.15936184
98Recurrent bronchitis (HP:0002837)2.15435674
99Recurrent otitis media (HP:0000403)2.15162077
100Pallor (HP:0000980)2.14331931
101Gastrointestinal stroma tumor (HP:0100723)2.14113533
102Amyotrophic lateral sclerosis (HP:0007354)2.13804893
103Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13417774
104Aplasia/Hypoplasia of the spleen (HP:0010451)2.13362882
105Supernumerary ribs (HP:0005815)2.12739964
106Verrucae (HP:0200043)2.12251045
107Papilloma (HP:0012740)2.12251045
108Autoimmune thrombocytopenia (HP:0001973)2.10962829
109Cystic liver disease (HP:0006706)2.10948191
110Microvesicular hepatic steatosis (HP:0001414)2.08805249
111Abnormal mitochondria in muscle tissue (HP:0008316)2.08556624
112Increased IgE level (HP:0003212)2.05873314
113Petechiae (HP:0000967)2.02651541
114Neoplasm of the tracheobronchial system (HP:0100552)2.02577647
115Lissencephaly (HP:0001339)2.01430739
116Inflammation of the large intestine (HP:0002037)2.00904650
117Mitochondrial inheritance (HP:0001427)1.98278879
118Abnormality of the anterior horn cell (HP:0006802)1.96604860
119Degeneration of anterior horn cells (HP:0002398)1.96604860
120Hepatosplenomegaly (HP:0001433)1.96308296
121Birth length less than 3rd percentile (HP:0003561)1.96119279
122Abnormal platelet volume (HP:0011876)1.95144553
123Supernumerary bones of the axial skeleton (HP:0009144)1.95108846
124Oligodactyly (hands) (HP:0001180)1.94651556
125Epistaxis (HP:0000421)1.93104315
126Sclerocornea (HP:0000647)1.92941674
12711 pairs of ribs (HP:0000878)1.91901171
128Microretrognathia (HP:0000308)1.91867027
129Trigonocephaly (HP:0000243)1.90892481
130Hypertensive crisis (HP:0100735)1.90819936
131Male pseudohermaphroditism (HP:0000037)1.89930391
132Parakeratosis (HP:0001036)1.88683777
133Pancytopenia (HP:0001876)1.88233514
134Progressive macrocephaly (HP:0004481)1.88084851
135Abnormality of the renal medulla (HP:0100957)1.88083449
136Deep palmar crease (HP:0006191)1.87892554
137Abnormal spermatogenesis (HP:0008669)1.87375454
138Oculomotor apraxia (HP:0000657)1.86758181
139Gastrointestinal inflammation (HP:0004386)1.85860990
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.85509953
141Muscle fiber atrophy (HP:0100295)1.84624095
142Facial cleft (HP:0002006)1.83544326
143Neonatal respiratory distress (HP:0002643)1.82635928
144Oligodactyly (HP:0012165)1.82604013
145Gonadotropin excess (HP:0000837)1.81903389
146Absent hand (HP:0004050)1.80976387
147Recurrent cutaneous fungal infections (HP:0011370)1.79940634
148Chronic mucocutaneous candidiasis (HP:0002728)1.79940634
149Preaxial hand polydactyly (HP:0001177)1.79811583
150Acute lymphatic leukemia (HP:0006721)1.79773679
151Neutropenia (HP:0001875)1.79574701
152Retinal dysplasia (HP:0007973)1.77243097
153Type I transferrin isoform profile (HP:0003642)1.75898488
154Colon cancer (HP:0003003)1.75767791
155Macrocytic anemia (HP:0001972)1.75728515
156Pulmonary fibrosis (HP:0002206)1.75651840
157Recurrent skin infections (HP:0001581)1.75477612
158Sloping forehead (HP:0000340)1.74823059
159Keratoconjunctivitis sicca (HP:0001097)1.74803685
160Bone marrow hypocellularity (HP:0005528)1.74551004
161Abnormality of the preputium (HP:0100587)1.73454143
162Abnormality of lateral ventricle (HP:0030047)1.73030046
163Median cleft lip (HP:0000161)1.72113139
164Acute encephalopathy (HP:0006846)1.70844217
165Postaxial hand polydactyly (HP:0001162)1.70399002
166Myelodysplasia (HP:0002863)1.70355594
167Congenital hepatic fibrosis (HP:0002612)1.69931334
168Type 2 muscle fiber atrophy (HP:0003554)1.66565460
169Thrombocytosis (HP:0001894)1.66045166
170Hypoplasia of the brainstem (HP:0002365)1.65433122
171Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65433122
172Optic disc pallor (HP:0000543)1.65005999
173Increased CSF lactate (HP:0002490)1.64821024
174Poor coordination (HP:0002370)1.64765598
175Atrophy/Degeneration involving motor neurons (HP:0007373)1.63159862
176Optic nerve coloboma (HP:0000588)1.60863265
177Type II lissencephaly (HP:0007260)1.58613328
178Decreased activity of mitochondrial respiratory chain (HP:0008972)1.57062891
179Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.57062891
180Hepatocellular necrosis (HP:0001404)1.55595882
181Aplasia/Hypoplasia of the lens (HP:0008063)1.55310952
182Hyperalaninemia (HP:0003348)1.55277548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.15115140
2WEE14.06300984
3TAOK33.56840773
4PDK43.19315815
5PDK33.19315815
6DYRK33.11647130
7MAP3K122.56905823
8BUB12.51991310
9TNIK2.51439174
10PNCK2.46321517
11PIM22.45151261
12MAP3K102.45149676
13TESK12.32859044
14CDK192.32538288
15CSK2.23750770
16BCR2.16143754
17VRK12.13132516
18CDC72.00564647
19ITK1.99910870
20IKBKB1.93570264
21MAP3K141.92104866
22CCNB11.92082068
23PRPF4B1.91409213
24TRIM281.90939883
25TYRO31.86499173
26FES1.84040082
27EEF2K1.81277244
28BCKDK1.79937971
29TAOK11.74945675
30NEK21.73708620
31KIT1.73309298
32MAPK151.69958012
33MST41.63876131
34ICK1.62011459
35LCK1.61138013
36IRAK41.56846710
37IKBKE1.47667356
38MARK31.47609316
39MUSK1.46273419
40SRPK11.37270781
41TAOK21.34716438
42STK101.33082493
43PDK21.32540469
44SIK31.30759487
45HCK1.30014757
46MAP2K71.28100798
47PASK1.27511757
48CDK81.26994423
49CAMKK11.22309406
50MAPKAPK51.20819579
51MAP4K11.20670168
52GRK71.18269178
53BRSK11.18030596
54ATR1.17507305
55TBK11.14860162
56LYN1.13853034
57MAPK131.11707543
58TSSK61.10463678
59NME21.10197636
60BRSK21.08859809
61BMX1.05637003
62CHUK1.03918491
63UHMK11.01902582
64TNK21.01741442
65FGR1.01432086
66PLK10.99404796
67JAK30.98835246
68PRKCQ0.96673191
69DAPK10.96165464
70CHEK20.92727492
71TLK10.91666034
72BTK0.91491068
73DYRK20.91324618
74CDK70.91312392
75RAF10.87761501
76BRAF0.86631676
77ARAF0.86399915
78TYK20.86000557
79SCYL20.84746692
80AURKA0.83886288
81RPS6KB20.81028667
82ACVR1B0.77891277
83SYK0.77488028
84MINK10.76094866
85EPHB10.73318466
86BMPR20.72665034
87CSF1R0.71642100
88CDK40.69686846
89RPS6KA40.69040226
90JAK20.67874390
91RIPK40.67767664
92MAPK40.66275146
93NME10.66110288
94BRD40.65814903
95CASK0.65534749
96BLK0.65524933
97MKNK10.64565154
98MAP4K20.64148121
99ADRBK20.63679496
100NLK0.63666057
101MAP3K30.63545809
102TTK0.63298644
103JAK10.63099576
104NTRK20.62807958
105TESK20.61658632
106MAP3K50.57079503
107DYRK1B0.56995455
108MARK10.55955669
109TGFBR10.54998617
110CAMK10.54906024
111MAP3K40.54568046
112CSNK2A10.53340011
113HIPK20.53277619
114CDK11A0.52219728
115MARK20.52192991
116CAMKK20.52037124
117PTK2B0.51474838
118CHEK10.50660989
119YES10.50457451
120MAP3K110.49962169
121NTRK30.49528761
122AURKB0.49220534
123PRKCG0.48970743
124MATK0.48914820
125MAP2K60.48785188
126EPHA30.48211472
127CSNK2A20.47555541
128CDK180.47326975
129ZAP700.47058321
130MAP3K70.46320656
131FYN0.46083320
132MAPKAPK30.45311283
133TEC0.44457268
134PLK40.44252769
135MAP2K20.43624680
136KDR0.43270180
137PIM10.42402098
138CDK150.42319843
139GRK60.42095065
140FLT30.41938049
141IRAK20.41893187
142PDGFRB0.41423033
143PINK10.40544340
144SIK20.40542971
145TXK0.37954704
146INSR0.37434080
147EGFR0.37378968
148RPS6KB10.36545949
149KSR10.35235631
150RPS6KA20.34932282
151PAK10.34540609
152CDK30.34035410
153CSNK1G30.34011414
154IRAK10.33065699
155PAK40.32230195
156MAP2K30.31449723
157MAPK110.31065455
158IRAK30.28919429
159LRRK20.27066784
160PAK60.26427893
161CAMK40.24763442
162PAK30.24604852
163PDK10.23823637

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04967922
2Ribosome_Homo sapiens_hsa030103.94233893
3Mismatch repair_Homo sapiens_hsa034303.75483581
4Base excision repair_Homo sapiens_hsa034103.71178031
5Pyrimidine metabolism_Homo sapiens_hsa002403.05263954
6Homologous recombination_Homo sapiens_hsa034403.04673628
7Spliceosome_Homo sapiens_hsa030403.00360592
8Allograft rejection_Homo sapiens_hsa053302.86386897
9Fanconi anemia pathway_Homo sapiens_hsa034602.79346352
10Nucleotide excision repair_Homo sapiens_hsa034202.73037011
11Proteasome_Homo sapiens_hsa030502.71162465
12Autoimmune thyroid disease_Homo sapiens_hsa053202.71018596
13Graft-versus-host disease_Homo sapiens_hsa053322.66010773
14RNA polymerase_Homo sapiens_hsa030202.60797070
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.53585535
16Huntingtons disease_Homo sapiens_hsa050162.22068417
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17864533
18Osteoclast differentiation_Homo sapiens_hsa043802.09550595
19RNA transport_Homo sapiens_hsa030132.09018943
20Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06485926
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04912662
22Parkinsons disease_Homo sapiens_hsa050121.98237130
23Cell cycle_Homo sapiens_hsa041101.94777877
24Oxidative phosphorylation_Homo sapiens_hsa001901.92386906
25Basal transcription factors_Homo sapiens_hsa030221.91900190
26Purine metabolism_Homo sapiens_hsa002301.89653464
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.89484315
28TNF signaling pathway_Homo sapiens_hsa046681.87430343
29RNA degradation_Homo sapiens_hsa030181.79471056
30Non-homologous end-joining_Homo sapiens_hsa034501.77952260
31Chemokine signaling pathway_Homo sapiens_hsa040621.76192777
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66722496
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66455288
34Type I diabetes mellitus_Homo sapiens_hsa049401.66167779
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.64004574
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63209980
37Rheumatoid arthritis_Homo sapiens_hsa053231.45683289
38Salmonella infection_Homo sapiens_hsa051321.43354398
39Apoptosis_Homo sapiens_hsa042101.41837726
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.39286300
41mRNA surveillance pathway_Homo sapiens_hsa030151.29647001
42Viral myocarditis_Homo sapiens_hsa054161.23223163
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19940698
44Alzheimers disease_Homo sapiens_hsa050101.19513155
45Nicotine addiction_Homo sapiens_hsa050331.16041123
46Oocyte meiosis_Homo sapiens_hsa041141.16040593
47Leishmaniasis_Homo sapiens_hsa051401.15389473
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14352103
49Protein export_Homo sapiens_hsa030601.12720848
50Primary immunodeficiency_Homo sapiens_hsa053401.08121433
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04634253
52Sulfur relay system_Homo sapiens_hsa041221.02640370
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98566804
54Tuberculosis_Homo sapiens_hsa051520.96331779
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95868936
56Pentose phosphate pathway_Homo sapiens_hsa000300.95818466
57Influenza A_Homo sapiens_hsa051640.95519198
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94028845
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93394686
60Asthma_Homo sapiens_hsa053100.93380237
61Systemic lupus erythematosus_Homo sapiens_hsa053220.92603953
62Olfactory transduction_Homo sapiens_hsa047400.92225929
63Epstein-Barr virus infection_Homo sapiens_hsa051690.91253551
64Cardiac muscle contraction_Homo sapiens_hsa042600.90593288
65Malaria_Homo sapiens_hsa051440.90393968
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88979368
67One carbon pool by folate_Homo sapiens_hsa006700.87441336
68Toxoplasmosis_Homo sapiens_hsa051450.87362584
69Hepatitis C_Homo sapiens_hsa051600.86965916
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86785495
71Notch signaling pathway_Homo sapiens_hsa043300.84791180
72VEGF signaling pathway_Homo sapiens_hsa043700.84107784
73Regulation of autophagy_Homo sapiens_hsa041400.83474731
74Antigen processing and presentation_Homo sapiens_hsa046120.82214943
75N-Glycan biosynthesis_Homo sapiens_hsa005100.81006768
76Alcoholism_Homo sapiens_hsa050340.80277604
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.80191509
78African trypanosomiasis_Homo sapiens_hsa051430.78538661
79MAPK signaling pathway_Homo sapiens_hsa040100.77431856
80Amphetamine addiction_Homo sapiens_hsa050310.76975332
81Synaptic vesicle cycle_Homo sapiens_hsa047210.74801426
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.74206172
83Endocytosis_Homo sapiens_hsa041440.72895968
84Chronic myeloid leukemia_Homo sapiens_hsa052200.72562654
85Non-small cell lung cancer_Homo sapiens_hsa052230.71462021
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71066837
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70702744
88Herpes simplex infection_Homo sapiens_hsa051680.66558962
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66532766
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65871904
91p53 signaling pathway_Homo sapiens_hsa041150.65300253
92Hematopoietic cell lineage_Homo sapiens_hsa046400.63209360
93Pancreatic cancer_Homo sapiens_hsa052120.62939113
94ErbB signaling pathway_Homo sapiens_hsa040120.62323621
95Choline metabolism in cancer_Homo sapiens_hsa052310.61611278
96Pyruvate metabolism_Homo sapiens_hsa006200.60892023
97Prolactin signaling pathway_Homo sapiens_hsa049170.58164469
98Platelet activation_Homo sapiens_hsa046110.57795794
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56271988
100Endometrial cancer_Homo sapiens_hsa052130.55947173
101Renal cell carcinoma_Homo sapiens_hsa052110.55258125
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.53418775
103FoxO signaling pathway_Homo sapiens_hsa040680.49078461
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.48759455
105HTLV-I infection_Homo sapiens_hsa051660.48293466
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48177535
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47705695
108Collecting duct acid secretion_Homo sapiens_hsa049660.47667051
109Phagosome_Homo sapiens_hsa041450.47634563
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46926666
111Pertussis_Homo sapiens_hsa051330.46311237
112Ras signaling pathway_Homo sapiens_hsa040140.44596955
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43691098
114Circadian entrainment_Homo sapiens_hsa047130.42340471
115Vitamin B6 metabolism_Homo sapiens_hsa007500.42233143
116Calcium signaling pathway_Homo sapiens_hsa040200.40031188
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.39874162
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39666136
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39622600
120Fatty acid biosynthesis_Homo sapiens_hsa000610.38772369
121Metabolic pathways_Homo sapiens_hsa011000.37960202
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37565825
123B cell receptor signaling pathway_Homo sapiens_hsa046620.35143564
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34953929
125Phototransduction_Homo sapiens_hsa047440.32401916
126Fructose and mannose metabolism_Homo sapiens_hsa000510.32176688
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31931231
128Dopaminergic synapse_Homo sapiens_hsa047280.31388438
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31159710
130Viral carcinogenesis_Homo sapiens_hsa052030.31027030
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30309081
132Long-term potentiation_Homo sapiens_hsa047200.29971231
133Biosynthesis of amino acids_Homo sapiens_hsa012300.29939658
134Lysosome_Homo sapiens_hsa041420.29508118
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29337633
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.29248659
137Taste transduction_Homo sapiens_hsa047420.29208070
138Glucagon signaling pathway_Homo sapiens_hsa049220.27934784
139Colorectal cancer_Homo sapiens_hsa052100.27676418
140Rap1 signaling pathway_Homo sapiens_hsa040150.27669275
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27039502
142Hepatitis B_Homo sapiens_hsa051610.26322364
143Acute myeloid leukemia_Homo sapiens_hsa052210.26022562
144Cocaine addiction_Homo sapiens_hsa050300.25235301
145Shigellosis_Homo sapiens_hsa051310.25077185
146Linoleic acid metabolism_Homo sapiens_hsa005910.24789047
147Cholinergic synapse_Homo sapiens_hsa047250.24720741
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24325244
149Prostate cancer_Homo sapiens_hsa052150.24022481
150Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23955361
151Glutamatergic synapse_Homo sapiens_hsa047240.23866451
152Morphine addiction_Homo sapiens_hsa050320.23788294
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23278409
154Hedgehog signaling pathway_Homo sapiens_hsa043400.22858538
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22848462
156Legionellosis_Homo sapiens_hsa051340.22175523
157Wnt signaling pathway_Homo sapiens_hsa043100.21875237
158Folate biosynthesis_Homo sapiens_hsa007900.21247131
159RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20173457
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18068893
161Measles_Homo sapiens_hsa051620.16816661
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.16687583
163Carbon metabolism_Homo sapiens_hsa012000.14831715
164Vibrio cholerae infection_Homo sapiens_hsa051100.12779284
165T cell receptor signaling pathway_Homo sapiens_hsa046600.11298060

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