PBXIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.85218023
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.85218023
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62124456
4muscle filament sliding (GO:0030049)5.55063273
5actin-myosin filament sliding (GO:0033275)5.55063273
6regulation of skeletal muscle contraction (GO:0014819)5.22060558
7actin-mediated cell contraction (GO:0070252)4.64143793
8negative thymic T cell selection (GO:0045060)4.45452404
9plasma membrane repair (GO:0001778)4.44675747
10negative T cell selection (GO:0043383)4.40481016
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31728047
12regulation of gamma-delta T cell activation (GO:0046643)4.29955718
13sarcomere organization (GO:0045214)4.23915041
14regulation of B cell receptor signaling pathway (GO:0050855)3.97329800
15thymic T cell selection (GO:0045061)3.95662682
16actin filament-based movement (GO:0030048)3.93654300
17T cell migration (GO:0072678)3.88832642
18negative regulation of erythrocyte differentiation (GO:0045647)3.84606811
19positive T cell selection (GO:0043368)3.83483635
20skeletal muscle contraction (GO:0003009)3.82006273
21response to interleukin-15 (GO:0070672)3.77637405
22leukocyte aggregation (GO:0070486)3.74315306
23T cell selection (GO:0045058)3.73143365
24skeletal muscle adaptation (GO:0043501)3.71575015
25tolerance induction (GO:0002507)3.70891592
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.47864322
27detection of other organism (GO:0098543)3.42479420
28detection of bacterium (GO:0016045)3.41504475
29negative regulation of leukocyte mediated immunity (GO:0002704)3.39068501
30B cell receptor signaling pathway (GO:0050853)3.35024436
31myofibril assembly (GO:0030239)3.34981789
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.34758868
33cellular response to interleukin-15 (GO:0071350)3.34497076
34regulation of T cell tolerance induction (GO:0002664)3.28992213
35response to muramyl dipeptide (GO:0032495)3.27314619
36neutrophil activation involved in immune response (GO:0002283)3.27191499
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25012307
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.25012307
39modulation by symbiont of host immune response (GO:0052553)3.25012307
40positive regulation by symbiont of host defense response (GO:0052509)3.25012307
41modulation by symbiont of host defense response (GO:0052031)3.25012307
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25012307
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20060962
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19767065
45actomyosin structure organization (GO:0031032)3.19015894
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.18073589
47cellular extravasation (GO:0045123)3.14183668
48negative regulation of T cell mediated immunity (GO:0002710)3.12943657
49positive regulation of B cell differentiation (GO:0045579)3.12885475
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.12221223
51cardiac myofibril assembly (GO:0055003)3.12055906
52regulation of B cell differentiation (GO:0045577)3.08956879
53striated muscle contraction (GO:0006941)3.08724015
54regulation of regulatory T cell differentiation (GO:0045589)3.06052094
55regulation of tolerance induction (GO:0002643)3.05528204
56regulation of p38MAPK cascade (GO:1900744)3.04300561
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99306285
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99306285
59striated muscle atrophy (GO:0014891)2.98767232
60antigen processing and presentation via MHC class Ib (GO:0002475)2.98156432
61germinal center formation (GO:0002467)2.97837402
62growth hormone receptor signaling pathway (GO:0060396)2.96508751
63negative regulation of cardiac muscle tissue growth (GO:0055022)2.94114175
64negative regulation of heart growth (GO:0061117)2.94114175
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.93731074
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93593283
67positive regulation of histone deacetylation (GO:0031065)2.92503296
68negative regulation of potassium ion transmembrane transport (GO:1901380)2.90545402
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86664777
70regulation of T cell mediated cytotoxicity (GO:0001914)2.85517323
71detection of external biotic stimulus (GO:0098581)2.84992373
72regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84059330
73regulation of natural killer cell mediated immunity (GO:0002715)2.82863266
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82863266
75antigen processing and presentation of endogenous antigen (GO:0019883)2.82033101
76cardiac muscle contraction (GO:0060048)2.81344605
77regulation of alpha-beta T cell proliferation (GO:0046640)2.79448302
78skeletal muscle fiber development (GO:0048741)2.78784581
79response to type I interferon (GO:0034340)2.77881252
80type I interferon signaling pathway (GO:0060337)2.77827964
81cellular response to type I interferon (GO:0071357)2.77827964
82activated T cell proliferation (GO:0050798)2.77410132
83muscle contraction (GO:0006936)2.76962293
84immunoglobulin mediated immune response (GO:0016064)2.75776103
85negative regulation of fatty acid transport (GO:2000192)2.74527361
86negative regulation of innate immune response (GO:0045824)2.74450057
87vascular endothelial growth factor signaling pathway (GO:0038084)2.74406451
88macrophage activation involved in immune response (GO:0002281)2.74134723
89positive regulation of myotube differentiation (GO:0010831)2.73302182
90positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73116367
91endodermal cell differentiation (GO:0035987)2.71748532
92neutrophil activation (GO:0042119)2.71636064
93positive regulation of p38MAPK cascade (GO:1900745)2.71285280
94antigen receptor-mediated signaling pathway (GO:0050851)2.69970245
95creatine metabolic process (GO:0006600)2.69223681
96epithelial cell-cell adhesion (GO:0090136)2.67792748
97negative regulation of T-helper cell differentiation (GO:0045623)2.66747505
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66747505
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66049355
100positive regulation of granulocyte differentiation (GO:0030854)2.65914610
101lymphocyte migration (GO:0072676)2.65593348
102negative regulation of type 2 immune response (GO:0002829)2.64522045
103regulation of T-helper 2 cell differentiation (GO:0045628)2.63549867
104mannose metabolic process (GO:0006013)2.62340882
105response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.60569799
106T cell receptor signaling pathway (GO:0050852)2.59955446
107apoptotic cell clearance (GO:0043277)2.58814396
108cellular response to growth hormone stimulus (GO:0071378)2.58579018
109negative regulation of glycoprotein biosynthetic process (GO:0010561)2.58335669
110positive regulation of Rap GTPase activity (GO:0032854)2.58282186
111dendritic cell chemotaxis (GO:0002407)2.57355052
112regulation of actin filament-based movement (GO:1903115)2.56461521
113regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55772113
114regulation of leukocyte degranulation (GO:0043300)2.55693019
115regulation of mast cell degranulation (GO:0043304)2.54237157
116muscle system process (GO:0003012)2.53040043
117Peyers patch development (GO:0048541)2.52985843
118mucosal-associated lymphoid tissue development (GO:0048537)2.52985843
119positive regulation of glycogen biosynthetic process (GO:0045725)2.52130106
120regulation of relaxation of muscle (GO:1901077)2.51343009
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.51132713
122granulocyte activation (GO:0036230)2.50187075
123negative regulation of interleukin-12 production (GO:0032695)2.49791118
124cell-substrate junction assembly (GO:0007044)2.49320185
125potassium ion import (GO:0010107)2.48647906
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.48442178
127negative regulation of stress fiber assembly (GO:0051497)2.48371669
128stress fiber assembly (GO:0043149)2.48295318
129positive thymic T cell selection (GO:0045059)2.47740237
130signal complex assembly (GO:0007172)2.46816452
131regulation of interferon-beta biosynthetic process (GO:0045357)2.46252055
132interferon-gamma-mediated signaling pathway (GO:0060333)2.45454447
133regulation of granulocyte differentiation (GO:0030852)2.45163830
134regulation of leukocyte mediated cytotoxicity (GO:0001910)2.44673081
135basement membrane organization (GO:0071711)2.44454420
136regulation of interleukin-2 biosynthetic process (GO:0045076)2.43778999
137B cell homeostasis (GO:0001782)2.43746884
138myeloid cell activation involved in immune response (GO:0002275)2.43208341
139detection of biotic stimulus (GO:0009595)2.42829138
140negative regulation of interleukin-6 production (GO:0032715)2.41662469
141regulation of extracellular matrix disassembly (GO:0010715)2.41226920
142detection of molecule of bacterial origin (GO:0032490)2.40598693
143regulation of necroptotic process (GO:0060544)2.40396079
144muscle atrophy (GO:0014889)2.39756335
145regulation of defense response to virus by virus (GO:0050690)2.39561595
146respiratory burst (GO:0045730)2.39044743
147carnitine shuttle (GO:0006853)2.38953659
148striated muscle adaptation (GO:0014888)2.38760775
149negative regulation of cell size (GO:0045792)2.38031949
150glomerular basement membrane development (GO:0032836)2.34327138
151muscle fiber development (GO:0048747)2.33428504
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32614854
153glomerular epithelial cell development (GO:0072310)2.31134735
154cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30608705
155positive regulation of tolerance induction (GO:0002645)2.29971651
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29651906
157positive regulation of myoblast differentiation (GO:0045663)2.28964608
158positive regulation of natural killer cell differentiation (GO:0032825)2.28910128
159myotube cell development (GO:0014904)2.28371905
160positive regulation of astrocyte differentiation (GO:0048711)2.27138099
161regulation of striated muscle contraction (GO:0006942)2.26971879
162cell adhesion mediated by integrin (GO:0033627)2.24474329
163collagen fibril organization (GO:0030199)2.22298422
164response to muscle activity (GO:0014850)2.22255618
165regulation of macrophage cytokine production (GO:0010935)2.22250694
166protein heterotrimerization (GO:0070208)2.20945024
167focal adhesion assembly (GO:0048041)2.20572540
168cell-substrate adherens junction assembly (GO:0007045)2.20572540
169relaxation of cardiac muscle (GO:0055119)2.20468658
170keratan sulfate catabolic process (GO:0042340)2.20137449
171cardiac muscle cell development (GO:0055013)2.20124581
172response to inactivity (GO:0014854)2.19859957
173syncytium formation (GO:0006949)2.19672803
174positive regulation of gamma-delta T cell activation (GO:0046645)2.19475072
175positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19280733
176glycogen catabolic process (GO:0005980)2.17927490
177positive regulation of blood vessel endothelial cell migration (GO:0043536)2.16591055
178pyrimidine ribonucleoside catabolic process (GO:0046133)2.16511922
179JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.14838089
180cardiac cell development (GO:0055006)2.14413292
181adherens junction assembly (GO:0034333)2.14201699
182regulation of cell communication by electrical coupling (GO:0010649)2.12726811
183heart trabecula formation (GO:0060347)2.12150460
184positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.11716135
185response to fluid shear stress (GO:0034405)2.11154156
186regulation of gamma-delta T cell differentiation (GO:0045586)2.10154673
187regulation of interleukin-12 biosynthetic process (GO:0045075)2.08701170
188muscle adaptation (GO:0043500)2.07658377
189regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.07154732
190regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.06802948
191sodium ion export (GO:0071436)2.06046909
192adhesion of symbiont to host cell (GO:0044650)2.05988216
193virion attachment to host cell (GO:0019062)2.05988216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.26120592
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.12978305
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.04954368
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81244106
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78823473
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.57168415
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30944120
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27399046
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26522156
10CLOCK_20551151_ChIP-Seq_293T_Human2.26273871
11SCL_19346495_ChIP-Seq_HPC-7_Human2.17050665
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11139938
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.06058450
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.03386790
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99643969
16TBX20_22080862_ChIP-Seq_HEART_Mouse1.98366946
17TBX20_22328084_ChIP-Seq_HEART_Mouse1.98366946
18RUNX1_22412390_ChIP-Seq_EML_Mouse1.95971820
19* MYB_26560356_Chip-Seq_TH2_Human1.95872032
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79433282
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.77002651
22* MAF_26560356_Chip-Seq_TH2_Human1.76975267
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.74668288
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73881155
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73011645
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72844064
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72748846
28* MYB_26560356_Chip-Seq_TH1_Human1.70946540
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.70463708
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.69546163
31* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65610211
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.64964482
33KDM2B_26808549_Chip-Seq_DND41_Human1.64849279
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64025318
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.63061989
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58584835
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57541361
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56766426
39RUNX_20019798_ChIP-Seq_JUKART_Human1.53022554
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48122841
41SPI1_23547873_ChIP-Seq_NB4_Human1.47642132
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47121788
43LXR_22292898_ChIP-Seq_THP-1_Human1.45727157
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45505496
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45046596
46TCF7_22412390_ChIP-Seq_EML_Mouse1.44686455
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44348421
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.44030657
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43271479
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.41800239
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40735709
52CJUN_26792858_Chip-Seq_BT549_Human1.36278160
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.34796959
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33598713
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33119563
56RACK7_27058665_Chip-Seq_MCF-7_Human1.32982642
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.31818836
58SPI1_23127762_ChIP-Seq_K562_Human1.31446023
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30808062
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30009396
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28007584
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27502415
63* MAF_26560356_Chip-Seq_TH1_Human1.26858389
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26570713
65VDR_21846776_ChIP-Seq_THP-1_Human1.26253153
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25711859
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25044930
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23999399
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.22961700
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22266519
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.22186703
72* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21908567
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.21545426
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21215975
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20803906
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20270366
77KDM2B_26808549_Chip-Seq_K562_Human1.19942304
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19892499
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.19732564
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19490601
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18733715
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17627247
83SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15051623
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14678269
85VDR_24787735_ChIP-Seq_THP-1_Human1.13378969
86* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13249592
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13176340
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13091843
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12989489
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.12817547
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12409281
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11647593
93DROSHA_22980978_ChIP-Seq_HELA_Human1.11155377
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10562640
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10451163
96* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10329153
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10285702
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09988782
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08829075
100* BCL6_27268052_Chip-Seq_Bcells_Human1.08400416
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07478523
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07462257
103BCOR_27268052_Chip-Seq_Bcells_Human1.07440736
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06268114
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06193864
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03520053
107UTX_26944678_Chip-Seq_JUKART_Human1.03264197
108VDR_24763502_ChIP-Seq_THP-1_Human1.03049409
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01843699
110GATA2_19941826_ChIP-Seq_K562_Human1.01705446
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01401440
112* P68_20966046_ChIP-Seq_HELA_Human1.01201963
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01028490
114DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00777718
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99520303
116PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99029821
117* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98909243
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98512014
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98031276
120* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97936399
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.97632990
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97476834
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97054612
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96616254
125SMC4_20622854_ChIP-Seq_HELA_Human0.96449859
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95883424
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95883424
128PU_27001747_Chip-Seq_BMDM_Mouse0.95583504
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95492081
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94218625
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94146279
132NCOR1_26117541_ChIP-Seq_K562_Human0.93898069
133SOX2_20726797_ChIP-Seq_SW620_Human0.93690964
134* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93643215
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92923927
136ZNF263_19887448_ChIP-Seq_K562_Human0.92805039
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92628217
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.92529804
139MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92482463
140MYC_22102868_ChIP-Seq_BL_Human0.92461093
141GATA1_19941826_ChIP-Seq_K562_Human0.91358276
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91153376
143* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90711060
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90279241
145BRD4_25478319_ChIP-Seq_HGPS_Human0.89631946
146CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87913728
147RXR_22158963_ChIP-Seq_LIVER_Mouse0.87375613
148* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86696191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.70647109
2MP0000751_myopathy3.65343196
3MP0008438_abnormal_cutaneous_collagen3.41711875
4MP0002837_dystrophic_cardiac_calcinosis3.40258584
5MP0000749_muscle_degeneration3.22582417
6MP0003763_abnormal_thymus_physiology3.20122427
7MP0005671_abnormal_response_to2.78710767
8MP0004084_abnormal_cardiac_muscle2.67895588
9MP0001800_abnormal_humoral_immune2.65497962
10MP0005000_abnormal_immune_tolerance2.64511462
11MP0003279_aneurysm2.62728277
12MP0004036_abnormal_muscle_relaxation2.61931765
13MP0003300_gastrointestinal_ulcer2.54213472
14MP0004145_abnormal_muscle_electrophysio2.51233437
15MP0005464_abnormal_platelet_physiology2.49753697
16MP0000750_abnormal_muscle_regeneration2.46431734
17MP0005025_abnormal_response_to2.43694062
18MP0002419_abnormal_innate_immunity2.40488638
19MP0004087_abnormal_muscle_fiber2.40477901
20MP0002723_abnormal_immune_serum2.31880641
21MP0002420_abnormal_adaptive_immunity2.29655528
22MP0003646_muscle_fatigue2.28834988
23MP0001819_abnormal_immune_cell2.26730419
24MP0001958_emphysema2.24211785
25MP0000747_muscle_weakness2.18469302
26MP0002452_abnormal_antigen_presenting2.16454221
27MP0004130_abnormal_muscle_cell2.15694525
28MP0003705_abnormal_hypodermis_morpholog2.13907493
29MP0002106_abnormal_muscle_physiology2.13742921
30MP0000733_abnormal_muscle_development2.11544636
31MP0000465_gastrointestinal_hemorrhage2.06911587
32MP0005275_abnormal_skin_tensile2.05577441
33MP0010155_abnormal_intestine_physiology1.99946572
34MP0002148_abnormal_hypersensitivity_rea1.98778730
35MP0003566_abnormal_cell_adhesion1.97756937
36MP0003191_abnormal_cellular_cholesterol1.96888973
37MP0009785_altered_susceptibility_to1.96027978
38MP0000759_abnormal_skeletal_muscle1.93915479
39MP0003866_abnormal_defecation1.92535855
40MP0005620_abnormal_muscle_contractility1.90804977
41MP0004947_skin_inflammation1.87636823
42MP0000013_abnormal_adipose_tissue1.86420109
43MP0009333_abnormal_splenocyte_physiolog1.84391723
44MP0005330_cardiomyopathy1.83165713
45MP0002398_abnormal_bone_marrow1.82735461
46MP0005369_muscle_phenotype1.79019062
47MP0000716_abnormal_immune_system1.78927647
48MP0003172_abnormal_lysosome_physiology1.77823070
49MP0005623_abnormal_meninges_morphology1.77305574
50MP0002405_respiratory_system_inflammati1.76910252
51MP0003045_fibrosis1.75955856
52MP0006082_CNS_inflammation1.73811123
53MP0002269_muscular_atrophy1.63863677
54MP0003303_peritoneal_inflammation1.60735192
55MP0008260_abnormal_autophagy1.60686870
56MP0004215_abnormal_myocardial_fiber1.58363118
57MP0005503_abnormal_tendon_morphology1.57943238
58MP0002972_abnormal_cardiac_muscle1.55426225
59MP0010630_abnormal_cardiac_muscle1.54267381
60MP0000703_abnormal_thymus_morphology1.52086586
61MP0001845_abnormal_inflammatory_respons1.51952809
62MP0001851_eye_inflammation1.50083227
63MP0004510_myositis1.49205083
64MP0009384_cardiac_valve_regurgitation1.48238038
65MP0002722_abnormal_immune_system1.47788242
66MP0005670_abnormal_white_adipose1.47434732
67MP0000689_abnormal_spleen_morphology1.45750911
68MP0004272_abnormal_basement_membrane1.44746734
69MP0009840_abnormal_foam_cell1.41634578
70MP0005451_abnormal_body_composition1.40852007
71MP0002877_abnormal_melanocyte_morpholog1.40634371
72MP0002132_abnormal_respiratory_system1.40517041
73MP0003183_abnormal_peptide_metabolism1.40452182
74MP0002429_abnormal_blood_cell1.38507299
75MP0003091_abnormal_cell_migration1.37617301
76MP0005666_abnormal_adipose_tissue1.37599589
77MP0005058_abnormal_lysosome_morphology1.36893519
78MP0002396_abnormal_hematopoietic_system1.33438895
79MP0000343_altered_response_to1.31799757
80MP0002108_abnormal_muscle_morphology1.29503543
81MP0005375_adipose_tissue_phenotype1.25715054
82MP0001544_abnormal_cardiovascular_syste1.23183933
83MP0005385_cardiovascular_system_phenoty1.23183933
84MP0002166_altered_tumor_susceptibility1.23109218
85MP0004185_abnormal_adipocyte_glucose1.22986736
86MP0003828_pulmonary_edema1.21823667
87MP0004381_abnormal_hair_follicle1.21446891
88MP0006054_spinal_hemorrhage1.19560919
89MP0001873_stomach_inflammation1.17783699
90MP0000685_abnormal_immune_system1.17301047
91MP0002254_reproductive_system_inflammat1.16683476
92MP0003690_abnormal_glial_cell1.16491144
93MP0008004_abnormal_stomach_pH1.16482087
94MP0004484_altered_response_of1.15556111
95MP0008469_abnormal_protein_level1.13688627
96MP0004233_abnormal_muscle_weight1.13456312
97MP0008775_abnormal_heart_ventricle1.13303375
98MP0000767_abnormal_smooth_muscle1.12446653
99MP0002933_joint_inflammation1.11791996
100MP0000604_amyloidosis1.11629612
101MP0004883_abnormal_blood_vessel1.10493550
102MP0009780_abnormal_chondrocyte_physiolo1.07964856
103MP0005166_decreased_susceptibility_to1.07525268
104MP0000003_abnormal_adipose_tissue1.06984882
105MP0001879_abnormal_lymphatic_vessel1.05703645
106MP0008961_abnormal_basal_metabolism1.04847771
107MP0003329_amyloid_beta_deposits1.04351516
108MP0002009_preneoplasia1.04000880
109MP0009278_abnormal_bone_marrow1.02556832
110MP0009764_decreased_sensitivity_to0.97172482
111MP0003950_abnormal_plasma_membrane0.97016473
112MP0002168_other_aberrant_phenotype0.95997571
113MP0005076_abnormal_cell_differentiation0.95913250
114MP0005377_hearing/vestibular/ear_phenot0.95888557
115MP0003878_abnormal_ear_physiology0.95888557
116MP0002998_abnormal_bone_remodeling0.95521252
117MP0010352_gastrointestinal_tract_polyps0.95493612
118MP0005023_abnormal_wound_healing0.94849588
119MP0001533_abnormal_skeleton_physiology0.94528904
120MP0005257_abnormal_intraocular_pressure0.94496128
121MP0005310_abnormal_salivary_gland0.91250899
122MP0004858_abnormal_nervous_system0.89389368
123MP0002896_abnormal_bone_mineralization0.88721239
124MP0006138_congestive_heart_failure0.88147029
125MP0001790_abnormal_immune_system0.87773026
126MP0005387_immune_system_phenotype0.87773026
127MP0005167_abnormal_blood-brain_barrier0.87520406
128MP0002971_abnormal_brown_adipose0.87033966
129MP0003436_decreased_susceptibility_to0.86927376
130MP0001545_abnormal_hematopoietic_system0.84899526
131MP0005397_hematopoietic_system_phenotyp0.84899526
132MP0005164_abnormal_response_to0.84762936
133MP0002006_tumorigenesis0.84437556
134MP0001663_abnormal_digestive_system0.84020984
135MP0005165_increased_susceptibility_to0.83329891
136MP0002128_abnormal_blood_circulation0.80946635
137MP0000858_altered_metastatic_potential0.79523988
138MP0005508_abnormal_skeleton_morphology0.79501641
139MP0001299_abnormal_eye_distance/0.79124727
140MP0003075_altered_response_to0.78830581
141MP0003795_abnormal_bone_structure0.78136610
142MP0003137_abnormal_impulse_conducting0.77881451
143MP0008874_decreased_physiological_sensi0.77275883
144MP0002060_abnormal_skin_morphology0.77208318
145MP0003448_altered_tumor_morphology0.74555091
146MP0000266_abnormal_heart_morphology0.73699113
147MP0001835_abnormal_antigen_presentation0.72565771
148MP0002089_abnormal_postnatal_growth/wei0.72221224
149MP0005390_skeleton_phenotype0.70767929
150MP0009763_increased_sensitivity_to0.70716039
151MP0002295_abnormal_pulmonary_circulatio0.69921892
152MP0002234_abnormal_pharynx_morphology0.68726940
153MP0001853_heart_inflammation0.68397664
154MP0002138_abnormal_hepatobiliary_system0.68170757
155MP0010368_abnormal_lymphatic_system0.68094039
156MP0001765_abnormal_ion_homeostasis0.67892756
157MP0000249_abnormal_blood_vessel0.66881729
158MP0005075_abnormal_melanosome_morpholog0.66515860
159MP0002909_abnormal_adrenal_gland0.65381136
160MP0000681_abnormal_thyroid_gland0.62881596
161MP0004808_abnormal_hematopoietic_stem0.62765296
162MP0000920_abnormal_myelination0.61877896
163MP0002277_abnormal_respiratory_mucosa0.58961565
164MP0008569_lethality_at_weaning0.57207518
165MP0003453_abnormal_keratinocyte_physiol0.56727514

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)5.59159566
2Eczematoid dermatitis (HP:0000976)5.42813660
3Muscle fiber inclusion bodies (HP:0100299)5.24092499
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.19670147
5Exercise-induced myalgia (HP:0003738)4.92450748
6Exercise-induced muscle cramps (HP:0003710)4.64567518
7Nemaline bodies (HP:0003798)4.63467560
8Myositis (HP:0100614)4.43315563
9Muscle fiber splitting (HP:0003555)4.23160929
10Round ear (HP:0100830)4.19454054
11Distal arthrogryposis (HP:0005684)4.17389370
12Ulnar deviation of the wrist (HP:0003049)4.08004713
13Hyporeflexia of lower limbs (HP:0002600)4.02146191
14Difficulty running (HP:0009046)3.94975414
15Increased connective tissue (HP:0009025)3.92829478
16Calf muscle hypertrophy (HP:0008981)3.86812340
17Muscle hypertrophy of the lower extremities (HP:0008968)3.77423832
18Elevated erythrocyte sedimentation rate (HP:0003565)3.74932617
19Orchitis (HP:0100796)3.74257060
20Recurrent abscess formation (HP:0002722)3.71462084
21Recurrent bacterial skin infections (HP:0005406)3.68016310
22Myopathic facies (HP:0002058)3.67301283
23Abnormality of macrophages (HP:0004311)3.64847068
24Abnormality of the calf musculature (HP:0001430)3.55242525
25Prolonged bleeding time (HP:0003010)3.52494280
26Aortic aneurysm (HP:0004942)3.49847825
27Spontaneous hematomas (HP:0007420)3.49502020
28Retrobulbar optic neuritis (HP:0100654)3.44083014
29Optic neuritis (HP:0100653)3.44083014
30Cerebral aneurysm (HP:0004944)3.43962771
31Abnormality of skeletal muscle fiber size (HP:0012084)3.40467892
32EMG: myopathic abnormalities (HP:0003458)3.40466813
33Stomatitis (HP:0010280)3.32766785
34Asymmetric septal hypertrophy (HP:0001670)3.29964198
35Aortic dissection (HP:0002647)3.28693931
36Increased variability in muscle fiber diameter (HP:0003557)3.28668381
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.28564057
38Increased IgE level (HP:0003212)3.23878202
39Sudden death (HP:0001699)3.22108212
40Pustule (HP:0200039)3.15891641
41T lymphocytopenia (HP:0005403)3.15685546
42Meningitis (HP:0001287)3.15224053
43Gastrointestinal infarctions (HP:0005244)3.11942343
44Broad metatarsal (HP:0001783)3.11098971
45Recurrent gram-negative bacterial infections (HP:0005420)3.10203597
46Myoglobinuria (HP:0002913)3.05170027
47Protrusio acetabuli (HP:0003179)3.04587705
48Recurrent fungal infections (HP:0002841)3.04373099
49Frequent falls (HP:0002359)3.02046223
50Facial diplegia (HP:0001349)3.01807334
51Chronic obstructive pulmonary disease (HP:0006510)3.01666597
52Obstructive lung disease (HP:0006536)3.01666597
53Difficulty climbing stairs (HP:0003551)3.01445968
54Abnormality of the left ventricular outflow tract (HP:0011103)3.00962333
55Subaortic stenosis (HP:0001682)3.00962333
56Mediastinal lymphadenopathy (HP:0100721)2.98015464
57Mildly elevated creatine phosphokinase (HP:0008180)2.97088289
58Abnormality of T cell number (HP:0011839)2.95761909
59Vasculitis (HP:0002633)2.94289811
60Epistaxis (HP:0000421)2.92748200
61Premature rupture of membranes (HP:0001788)2.90720868
62Cellulitis (HP:0100658)2.82722513
63Ventricular tachycardia (HP:0004756)2.80704864
64Calcaneovalgus deformity (HP:0001848)2.77465661
65Scapular winging (HP:0003691)2.77358094
66Gastrointestinal inflammation (HP:0004386)2.71418718
67Right ventricular cardiomyopathy (HP:0011663)2.70007312
68Purpura (HP:0000979)2.69811102
69Gingivitis (HP:0000230)2.69310135
70Inflammation of the large intestine (HP:0002037)2.68210633
71Encephalitis (HP:0002383)2.65984984
72Gingival bleeding (HP:0000225)2.65001216
73Panhypogammaglobulinemia (HP:0003139)2.61010547
74Deformed tarsal bones (HP:0008119)2.60733420
75Chest pain (HP:0100749)2.59863608
76Pulmonary infiltrates (HP:0002113)2.58612486
77Increased density of long bones (HP:0006392)2.57385207
78Abnormality of T cells (HP:0002843)2.55471349
79Colitis (HP:0002583)2.53830663
80Papilledema (HP:0001085)2.53204904
81Recurrent skin infections (HP:0001581)2.52510103
82Keratoconjunctivitis sicca (HP:0001097)2.51456206
83Spinal rigidity (HP:0003306)2.49661821
84Absent phalangeal crease (HP:0006109)2.49347762
85Dysostosis multiplex (HP:0000943)2.45202915
86Granulocytopenia (HP:0001913)2.44038781
87Agammaglobulinemia (HP:0004432)2.43101641
88Malignant hyperthermia (HP:0002047)2.42459235
89Ankle contracture (HP:0006466)2.42096951
90Gastrointestinal stroma tumor (HP:0100723)2.38525844
91Neck muscle weakness (HP:0000467)2.38146465
92Shallow orbits (HP:0000586)2.37032502
93Petechiae (HP:0000967)2.35344750
94Myotonia (HP:0002486)2.33653643
95Chronic mucocutaneous candidiasis (HP:0002728)2.33064685
96Recurrent cutaneous fungal infections (HP:0011370)2.33064685
97Muscle stiffness (HP:0003552)2.31192569
98Recurrent viral infections (HP:0004429)2.30695345
99Autoimmune hemolytic anemia (HP:0001890)2.29812102
100Recurrent bronchitis (HP:0002837)2.29297772
101Urticaria (HP:0001025)2.24434152
102Keratoconjunctivitis (HP:0001096)2.24309830
103Leukocytosis (HP:0001974)2.23494546
104Aneurysm (HP:0002617)2.23327427
105Lipoatrophy (HP:0100578)2.22919543
106Increased IgM level (HP:0003496)2.21447413
107Gowers sign (HP:0003391)2.21422597
108Slender build (HP:0001533)2.20848392
109Interstitial pulmonary disease (HP:0006530)2.20664856
110Lymphopenia (HP:0001888)2.18696722
111Hypergammaglobulinemia (HP:0010702)2.17513151
112Pulmonary embolism (HP:0002204)2.17013725
113Hemoptysis (HP:0002105)2.16492859
114IgM deficiency (HP:0002850)2.16240520
115Rhabdomyolysis (HP:0003201)2.15836381
116Distal lower limb muscle weakness (HP:0009053)2.15024440
117Distal lower limb amyotrophy (HP:0008944)2.14051381
118Abnormal finger flexion creases (HP:0006143)2.13708741
119Arterial tortuosity (HP:0005116)2.13456702
120Vascular tortuosity (HP:0004948)2.11849564
121Papilloma (HP:0012740)2.11408990
122Verrucae (HP:0200043)2.11408990
123Abnormality of the calcaneus (HP:0008364)2.10486506
124Abnormality of T cell physiology (HP:0011840)2.10006264
125Tarsal synostosis (HP:0008368)2.09897381
126Systemic lupus erythematosus (HP:0002725)2.09380731
127Hypoplastic ischia (HP:0003175)2.08161241
128Generalized muscle weakness (HP:0003324)2.06284593
129Abnormal platelet volume (HP:0011876)2.04618044
130Emphysema (HP:0002097)2.03794397
131Centrally nucleated skeletal muscle fibers (HP:0003687)2.03172263
132Atrial fibrillation (HP:0005110)2.02935594
133Abnormality of cells of the lymphoid lineage (HP:0012140)2.02880445
134Episodic fever (HP:0001954)2.02342547
135Arterial thrombosis (HP:0004420)2.02342204
136Limb-girdle muscle atrophy (HP:0003797)2.02132678
137Eosinophilia (HP:0001880)2.01493861
138Fatigable weakness (HP:0003473)2.00528150
139Abnormality of the neuromuscular junction (HP:0003398)2.00528150
140Restrictive lung disease (HP:0002091)1.98057571
141Amyloidosis (HP:0011034)1.95880651
142Dilatation of the ascending aorta (HP:0005111)1.95703069
143Mitral valve prolapse (HP:0001634)1.95305018
144Obstructive sleep apnea (HP:0002870)1.94541418
145Atrophic scars (HP:0001075)1.92848028
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90267883
147Hypochromic anemia (HP:0001931)1.90257849
148Osteomyelitis (HP:0002754)1.89719629
149Slow saccadic eye movements (HP:0000514)1.89292549
150Synostosis involving bones of the lower limbs (HP:0009138)1.87968806
151Synostosis involving bones of the feet (HP:0009140)1.87968806
152Primary atrial arrhythmia (HP:0001692)1.87917024
153Bulbar palsy (HP:0001283)1.87229470
154Hematochezia (HP:0002573)1.87032440
155Menorrhagia (HP:0000132)1.86593482
156Premature loss of primary teeth (HP:0006323)1.86523535
157Cervical subluxation (HP:0003308)1.85719288
158Hip contracture (HP:0003273)1.84766210
159Acne (HP:0001061)1.84031554
160Abnormality of glycolipid metabolism (HP:0010969)1.83982400
161Abnormality of liposaccharide metabolism (HP:0010968)1.83982400
162Abnormality of glycosphingolipid metabolism (HP:0004343)1.83982400
163Dilated cardiomyopathy (HP:0001644)1.83624521
164Polygenic inheritance (HP:0010982)1.81954391
165Joint swelling (HP:0001386)1.81891708
166Glomerulopathy (HP:0100820)1.81486637
167Abnormality of eosinophils (HP:0001879)1.81238377
168Glomerulonephritis (HP:0000099)1.79863897
169Spondylolisthesis (HP:0003302)1.79681684
170Bundle branch block (HP:0011710)1.79451599
171Hyperkalemia (HP:0002153)1.78825358
172Hyperlipoproteinemia (HP:0010980)1.78156078
173Urinary glycosaminoglycan excretion (HP:0003541)1.78101108
174Mucopolysacchariduria (HP:0008155)1.78101108
175Loss of speech (HP:0002371)1.78018252
176Supraventricular arrhythmia (HP:0005115)1.77442969
177Supraventricular tachycardia (HP:0004755)1.73360023
178Proximal amyotrophy (HP:0007126)1.72354575
179Peritonitis (HP:0002586)1.71739162
180Abnormality of the ischium (HP:0003174)1.68210762
181Lower limb amyotrophy (HP:0007210)1.66675678
182Abnormality of the nasal mucosa (HP:0000433)1.65395432
183Muscular dystrophy (HP:0003560)1.63632087
184Easy fatigability (HP:0003388)1.63090271
185Bladder diverticulum (HP:0000015)1.61938970
186Ventricular arrhythmia (HP:0004308)1.61914880
187Fragile skin (HP:0001030)1.61297795
188Prolonged QT interval (HP:0001657)1.61294489
189Mesomelia (HP:0003027)1.60562113
190Wrist flexion contracture (HP:0001239)1.59950995
191Weak cry (HP:0001612)1.59618736
192Radial bowing (HP:0002986)1.58911213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.23753042
2TRIB34.52355681
3PRPF4B3.10918099
4RIPK42.99763285
5OBSCN2.82500584
6PKN22.67907022
7PHKG12.54074973
8PHKG22.54074973
9PIK3CG2.53888724
10DMPK2.44885315
11FES2.42358350
12ERN12.13249780
13MYLK2.12775531
14TAOK32.08125957
15LMTK22.07114544
16TXK2.03262984
17TNK21.95138705
18EPHB11.91254620
19SIK11.90247035
20TGFBR21.90113921
21PTK61.69976978
22RIPK11.64535787
23PDGFRA1.57630843
24LRRK21.53811043
25MAP3K101.52843566
26JAK11.52626437
27SYK1.49494416
28IRAK41.45678883
29MARK21.35891501
30EEF2K1.32559894
31PIK3CA1.30228972
32TYK21.29818179
33FGFR41.27610421
34MAP4K11.25662530
35MAP3K111.22154332
36MAP3K71.20483553
37MAP2K31.19048656
38LCK1.18924047
39FGFR31.15944566
40TRPM71.15570964
41SIK31.14807044
42EPHA31.14399990
43MAP3K11.12759165
44CAMKK11.07988754
45DDR21.07734224
46LYN1.01304427
47JAK30.98069616
48MAPK120.97421783
49MAPK70.97377574
50TBK10.97196814
51SIK20.96217772
52NEK90.96098607
53ILK0.95974878
54PDK10.94504454
55STK100.93508776
56MOS0.93433794
57BMX0.92427239
58TEC0.91807945
59ROCK10.90709070
60SMG10.89821446
61PAK30.89068190
62KSR20.88132368
63EPHB20.87242020
64DYRK1B0.84251658
65CAMK1G0.83706921
66TAOK10.82787328
67PRKCH0.82535302
68PAK20.81667804
69MAPKAPK30.80095300
70PAK40.79786075
71CAMK1D0.77655499
72PRKD10.76764157
73CSK0.75260671
74MAP2K20.73504897
75MAP3K130.72459772
76FGR0.69257765
77ITK0.69245841
78ROCK20.69174259
79HCK0.68846271
80PDGFRB0.67763484
81MAPK150.66029167
82CDC42BPA0.65826498
83TESK20.65590622
84PRKAA20.65011123
85PTK20.64580360
86STK380.64178596
87JAK20.63192034
88PRKCQ0.62568335
89MUSK0.61883537
90PDK40.61525766
91PDK30.61525766
92LATS10.60282689
93FYN0.60118071
94RET0.59787851
95FER0.58617561
96TAOK20.58586231
97ZAP700.58221014
98CAMKK20.57405944
99TIE10.57176184
100IRAK30.56156995
101RPS6KL10.55907314
102RPS6KC10.55907314
103PRKD20.55683204
104FRK0.54569326
105PIM10.53488112
106MAPK110.53223164
107MAP3K30.52297338
108PTK2B0.50788731
109HIPK20.50728027
110CHUK0.49859629
111STK240.49842191
112CDK120.49420010
113MAPK40.48699273
114KIT0.48457483
115FLT30.48363967
116BLK0.47517414
117TYRO30.46403638
118IKBKE0.45884510
119KDR0.45432014
120PDK20.45347439
121MTOR0.45271491
122SGK30.44462589
123ARAF0.44407475
124BTK0.43598503
125IRAK10.43465115
126RPS6KA60.42598948
127YES10.41282039
128MAP3K140.40940234
129FGFR10.40301679
130SGK20.39682267
131MAP2K10.39644479
132GRK60.39471810
133CSF1R0.39329274
134PDPK10.38606523
135PRKAA10.37825464
136CDK60.37497928
137DAPK30.36716666
138ICK0.35173388
139FGFR20.35079937
140IKBKB0.34706680
141PRKD30.34615652
142NLK0.34370214
143MARK30.34169347
144GRK50.33748435
145RPS6KA20.32043906

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.67001210
2Dilated cardiomyopathy_Homo sapiens_hsa054142.62025170
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31686746
4Autoimmune thyroid disease_Homo sapiens_hsa053202.14395962
5Allograft rejection_Homo sapiens_hsa053302.02853222
6Graft-versus-host disease_Homo sapiens_hsa053322.01400709
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97285958
8Focal adhesion_Homo sapiens_hsa045101.92062068
9Staphylococcus aureus infection_Homo sapiens_hsa051501.91754348
10Viral myocarditis_Homo sapiens_hsa054161.83163492
11ECM-receptor interaction_Homo sapiens_hsa045121.75302975
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.63137278
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.57531789
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.56592977
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51102742
16Proteoglycans in cancer_Homo sapiens_hsa052051.40765751
17Insulin resistance_Homo sapiens_hsa049311.39696678
18Osteoclast differentiation_Homo sapiens_hsa043801.35908254
19Leishmaniasis_Homo sapiens_hsa051401.32327383
20Amoebiasis_Homo sapiens_hsa051461.32269347
21Antigen processing and presentation_Homo sapiens_hsa046121.30241700
22Type I diabetes mellitus_Homo sapiens_hsa049401.29779194
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.27438772
24Toxoplasmosis_Homo sapiens_hsa051451.27146596
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25589445
26Chronic myeloid leukemia_Homo sapiens_hsa052201.23384393
27Cardiac muscle contraction_Homo sapiens_hsa042601.22113589
28B cell receptor signaling pathway_Homo sapiens_hsa046621.21795993
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21419087
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.15998567
31Gastric acid secretion_Homo sapiens_hsa049711.15249715
32Adherens junction_Homo sapiens_hsa045201.14539865
33Platelet activation_Homo sapiens_hsa046111.13740289
34Small cell lung cancer_Homo sapiens_hsa052221.11342101
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09727861
36Other glycan degradation_Homo sapiens_hsa005111.08767959
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07140245
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06818885
39Influenza A_Homo sapiens_hsa051641.05000516
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04876424
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03522891
42Insulin signaling pathway_Homo sapiens_hsa049101.03431943
43Lysosome_Homo sapiens_hsa041421.03310382
44Malaria_Homo sapiens_hsa051441.02099145
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00785422
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99607885
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99110999
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98375560
49Hepatitis C_Homo sapiens_hsa051600.95943330
50Hepatitis B_Homo sapiens_hsa051610.95899615
51Pancreatic cancer_Homo sapiens_hsa052120.94677612
52Herpes simplex infection_Homo sapiens_hsa051680.92407178
53Oxytocin signaling pathway_Homo sapiens_hsa049210.92196171
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91858196
55Asthma_Homo sapiens_hsa053100.90693523
56Acute myeloid leukemia_Homo sapiens_hsa052210.89607882
57VEGF signaling pathway_Homo sapiens_hsa043700.89259891
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.89257912
59Endocytosis_Homo sapiens_hsa041440.88078710
60HIF-1 signaling pathway_Homo sapiens_hsa040660.88031199
61Choline metabolism in cancer_Homo sapiens_hsa052310.85712140
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83012967
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.82961911
64Renal cell carcinoma_Homo sapiens_hsa052110.82321463
65Glucagon signaling pathway_Homo sapiens_hsa049220.82227910
66Protein digestion and absorption_Homo sapiens_hsa049740.82148896
67Bladder cancer_Homo sapiens_hsa052190.81909279
68TNF signaling pathway_Homo sapiens_hsa046680.80652398
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80601104
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80032683
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79864513
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.79322954
73Fatty acid degradation_Homo sapiens_hsa000710.79283444
74Inositol phosphate metabolism_Homo sapiens_hsa005620.78666673
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78322245
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78004432
77Tight junction_Homo sapiens_hsa045300.77660987
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77637519
79Tuberculosis_Homo sapiens_hsa051520.76765671
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75982688
81mTOR signaling pathway_Homo sapiens_hsa041500.75080110
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74988632
83AMPK signaling pathway_Homo sapiens_hsa041520.74479195
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74065953
85Renin secretion_Homo sapiens_hsa049240.73045891
86Glioma_Homo sapiens_hsa052140.72817197
87FoxO signaling pathway_Homo sapiens_hsa040680.72244757
88Prolactin signaling pathway_Homo sapiens_hsa049170.72082010
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71018063
90Phagosome_Homo sapiens_hsa041450.70361672
91Notch signaling pathway_Homo sapiens_hsa043300.70272798
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.69258288
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68829845
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.68464400
95Chemokine signaling pathway_Homo sapiens_hsa040620.68198069
96Pertussis_Homo sapiens_hsa051330.67226240
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66902261
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.66398440
99Salmonella infection_Homo sapiens_hsa051320.64966629
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64715787
101Starch and sucrose metabolism_Homo sapiens_hsa005000.64388788
102Measles_Homo sapiens_hsa051620.64369865
103Shigellosis_Homo sapiens_hsa051310.63795545
104Dorso-ventral axis formation_Homo sapiens_hsa043200.63773509
105T cell receptor signaling pathway_Homo sapiens_hsa046600.63629235
106Primary immunodeficiency_Homo sapiens_hsa053400.62953821
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.62603456
108Thyroid hormone synthesis_Homo sapiens_hsa049180.62597607
109Rap1 signaling pathway_Homo sapiens_hsa040150.61099500
110Rheumatoid arthritis_Homo sapiens_hsa053230.61057391
111HTLV-I infection_Homo sapiens_hsa051660.60984212
112Fatty acid biosynthesis_Homo sapiens_hsa000610.60200607
113Non-small cell lung cancer_Homo sapiens_hsa052230.60123484
114Fatty acid metabolism_Homo sapiens_hsa012120.60056602
115Type II diabetes mellitus_Homo sapiens_hsa049300.59859712
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59807466
117GnRH signaling pathway_Homo sapiens_hsa049120.59717646
118MAPK signaling pathway_Homo sapiens_hsa040100.59291918
119Colorectal cancer_Homo sapiens_hsa052100.58860241
120MicroRNAs in cancer_Homo sapiens_hsa052060.58559110
121Long-term potentiation_Homo sapiens_hsa047200.58384958
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58381935
123Endometrial cancer_Homo sapiens_hsa052130.58136494
124African trypanosomiasis_Homo sapiens_hsa051430.58135455
125Nitrogen metabolism_Homo sapiens_hsa009100.58135042
126Apoptosis_Homo sapiens_hsa042100.57509799
127Estrogen signaling pathway_Homo sapiens_hsa049150.57508532
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.57352752
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57160049
130Hematopoietic cell lineage_Homo sapiens_hsa046400.57036691
131Circadian rhythm_Homo sapiens_hsa047100.57023324
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55626580
133ErbB signaling pathway_Homo sapiens_hsa040120.53905387
134Legionellosis_Homo sapiens_hsa051340.52782590
135Viral carcinogenesis_Homo sapiens_hsa052030.52597687
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51285231
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51002893
138Prion diseases_Homo sapiens_hsa050200.49684692
139Ras signaling pathway_Homo sapiens_hsa040140.46214236

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