ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	complement activation, alternative pathway (GO:0006957)	5.82934229
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.66906189
3	L-phenylalanine metabolic process (GO:0006558)	5.66906189
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.63454658
5	L-phenylalanine catabolic process (GO:0006559)	5.63454658
6	urea metabolic process (GO:0019627)	5.32272324
7	regulation of protein activation cascade (GO:2000257)	5.25397719
8	low-density lipoprotein particle clearance (GO:0034383)	5.02541913
9	protein carboxylation (GO:0018214)	5.02482371
10	peptidyl-glutamic acid carboxylation (GO:0017187)	5.02482371
11	regulation of complement activation (GO:0030449)	5.01448951
12	urea cycle (GO:0000050)	5.00509246
13	negative regulation of fibrinolysis (GO:0051918)	4.96470301
14	regulation of fibrinolysis (GO:0051917)	4.84732709
15	nitrogen cycle metabolic process (GO:0071941)	4.79407289
16	epoxygenase P450 pathway (GO:0019373)	4.73184479
17	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.63920086
18	omega-hydroxylase P450 pathway (GO:0097267)	4.63794172
19	ethanol oxidation (GO:0006069)	4.56260670
20	acylglycerol catabolic process (GO:0046464)	4.38052147
21	neutral lipid catabolic process (GO:0046461)	4.38052147
22	triglyceride catabolic process (GO:0019433)	4.36135759
23	exogenous drug catabolic process (GO:0042738)	4.32495045
24	plasma lipoprotein particle clearance (GO:0034381)	4.27809716
25	positive regulation of triglyceride lipase activity (GO:0061365)	4.23457453
26	positive regulation of lipoprotein lipase activity (GO:0051006)	4.23457453
27	regulation of cholesterol esterification (GO:0010872)	4.08536009
28	regulation of cholesterol biosynthetic process (GO:0045540)	4.06781023
29	alpha-linolenic acid metabolic process (GO:0036109)	4.01306181
30	glyoxylate metabolic process (GO:0046487)	4.00880389
31	drug catabolic process (GO:0042737)	3.99405830
32	regulation of plasminogen activation (GO:0010755)	3.93865660
33	fibrinolysis (GO:0042730)	3.86283974
34	fatty acid homeostasis (GO:0055089)	3.75475659
35	ethanol metabolic process (GO:0006067)	3.72801999
36	negative regulation of cholesterol transport (GO:0032375)	3.70683944
37	negative regulation of sterol transport (GO:0032372)	3.70683944
38	plasma lipoprotein particle remodeling (GO:0034369)	3.66727404
39	protein-lipid complex remodeling (GO:0034368)	3.66727404
40	macromolecular complex remodeling (GO:0034367)	3.66727404
41	very-low-density lipoprotein particle assembly (GO:0034379)	3.61999228
42	acylglycerol homeostasis (GO:0055090)	3.56920095
43	triglyceride homeostasis (GO:0070328)	3.56920095
44	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.56322064
45	acute-phase response (GO:0006953)	3.48267541
46	negative regulation of lipase activity (GO:0060192)	3.46912233
47	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.43864271
48	blood coagulation, intrinsic pathway (GO:0007597)	3.42655221
49	cholesterol efflux (GO:0033344)	3.42363771
50	regulation of triglyceride catabolic process (GO:0010896)	3.38728953
51	regulation of cholesterol homeostasis (GO:2000188)	3.38303984
52	phospholipid efflux (GO:0033700)	3.37492669
53	glutamate metabolic process (GO:0006536)	3.37000864
54	diacylglycerol metabolic process (GO:0046339)	3.32622683
55	NADH metabolic process (GO:0006734)	3.31463687
56	regulation of cholesterol metabolic process (GO:0090181)	3.26260479
57	positive regulation of lipid catabolic process (GO:0050996)	3.21253358
58	glycerolipid catabolic process (GO:0046503)	3.20615151
59	proline metabolic process (GO:0006560)	3.19859979
60	opsonization (GO:0008228)	3.18728560
61	protein activation cascade (GO:0072376)	3.14272224
62	aromatic amino acid family catabolic process (GO:0009074)	3.12289731
63	bile acid metabolic process (GO:0008206)	3.11783378
64	positive regulation of triglyceride metabolic process (GO:0090208)	3.10679209
65	high-density lipoprotein particle remodeling (GO:0034375)	3.10175372
66	negative regulation of blood coagulation (GO:0030195)	3.09100005
67	negative regulation of hemostasis (GO:1900047)	3.09100005
68	plasma lipoprotein particle assembly (GO:0034377)	3.08568240
69	regulation of apoptotic cell clearance (GO:2000425)	3.08399136
70	drug metabolic process (GO:0017144)	3.08202198
71	bile acid biosynthetic process (GO:0006699)	3.07482389
72	intestinal cholesterol absorption (GO:0030299)	3.05656943
73	dicarboxylic acid biosynthetic process (GO:0043650)	3.05573389
74	negative regulation of protein activation cascade (GO:2000258)	3.05536346
75	plasma lipoprotein particle organization (GO:0071827)	3.05209766
76	protein-lipid complex assembly (GO:0065005)	3.03562658
77	protein-lipid complex subunit organization (GO:0071825)	3.02682993
78	regulation of cholesterol storage (GO:0010885)	3.02214946
79	serine family amino acid catabolic process (GO:0009071)	2.98313842
80	glutamine family amino acid biosynthetic process (GO:0009084)	2.98011596
81	complement activation (GO:0006956)	2.97649129
82	triglyceride metabolic process (GO:0006641)	2.97425790
83	complement activation, classical pathway (GO:0006958)	2.92542355
84	acetyl-CoA metabolic process (GO:0006084)	2.92370557
85	regulation of triglyceride metabolic process (GO:0090207)	2.91151127
86	tricarboxylic acid metabolic process (GO:0072350)	2.87658337
87	negative regulation of lipid transport (GO:0032369)	2.87354631
88	tyrosine metabolic process (GO:0006570)	2.87077895
89	acylglycerol metabolic process (GO:0006639)	2.86679340
90	reverse cholesterol transport (GO:0043691)	2.84828063
91	neutral lipid metabolic process (GO:0006638)	2.81644562
92	negative regulation of coagulation (GO:0050819)	2.81276240
93	low-density lipoprotein particle remodeling (GO:0034374)	2.79755979
94	response to mercury ion (GO:0046689)	2.79527994
95	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.78737636
96	positive regulation of blood coagulation (GO:0030194)	2.77220675
97	positive regulation of hemostasis (GO:1900048)	2.77220675
98	regulation of fatty acid biosynthetic process (GO:0042304)	2.75870067
99	negative regulation of wound healing (GO:0061045)	2.74674168
100	positive regulation of steroid metabolic process (GO:0045940)	2.70972856

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.81591793
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.64214737
3	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.72148129
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.68515766
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.25148836
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.22335075
7	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.03986006
8	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.91150686
9	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.74445370
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.71607786
11	LXR_22292898_ChIP-Seq_THP-1_Human	2.59041992
12	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.52666745
13	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.46102144
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.34377368
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.29124258
16	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.26787214
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.19286468
18	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.15318685
19	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.97663484
20	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.97086767
21	RACK7_27058665_Chip-Seq_MCF-7_Human	1.87638446
22	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.85334479
23	* TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.72805165
24	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.71489003
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.70789815
26	* ELK3_25401928_ChIP-Seq_HUVEC_Human	1.69058782
27	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.65976157
28	KDM2B_26808549_Chip-Seq_K562_Human	1.62826686
29	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.62423064
30	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53730086
31	SMC4_20622854_ChIP-Seq_HELA_Human	1.51652875
32	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.50607122
33	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.47070900
34	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.45898084
35	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.44967471
36	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.44342115
37	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.43510630
38	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.43433397
39	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.42938726
40	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.42834707
41	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.41843216
42	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.39538130
43	P68_20966046_ChIP-Seq_HELA_Human	1.39299899
44	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.37490518
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.36497157
46	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.34810081
47	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.33607042
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.33321476
49	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.32761712
50	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.32009213
51	CTCF_27219007_Chip-Seq_Bcells_Human	1.30489239
52	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.27530276
53	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.25972822
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20843424
55	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.17849163
56	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.17231451
57	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.16504863
58	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.14124182
59	CREB1_26743006_Chip-Seq_LNCaP_Human	1.12860318
60	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12386278
61	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.11295327
62	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08424654
63	* P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.07542173
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05622039
65	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.04942686
66	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.04569886
67	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.04131333
68	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.00780088
69	KDM2B_26808549_Chip-Seq_DND41_Human	0.99765883
70	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.99068163
71	VDR_21846776_ChIP-Seq_THP-1_Human	0.97439342
72	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.97306691
73	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.95642947
74	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.95642947
75	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.95156351
76	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.94957210
77	* ATF3_27146783_Chip-Seq_COLON_Human	0.94804625
78	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.94615514
79	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.94555121
80	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.93826329
81	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.91726367
82	TCF7_22412390_ChIP-Seq_EML_Mouse	0.91472856
83	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.91145643
84	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.90791364
85	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.89599975
86	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.89558259
87	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.89224687
88	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.88558746
89	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.88202170
90	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.86750022
91	TP63_22573176_ChIP-Seq_HFKS_Human	0.86496873
92	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.86155786
93	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.85773701
94	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.85722194
95	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.85722194
96	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84945602
97	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.84869674
98	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.84859455
99	BCOR_27268052_Chip-Seq_Bcells_Human	0.84727462
100	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.84499302

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.32175416
2	MP0005360_urolithiasis	4.82043426
3	MP0005670_abnormal_white_adipose	4.20916991
4	MP0005365_abnormal_bile_salt	4.04847930
5	MP0005085_abnormal_gallbladder_physiolo	3.30547880
6	MP0009840_abnormal_foam_cell	3.11529802
7	MP0008875_abnormal_xenobiotic_pharmacok	3.07514218
8	MP0010329_abnormal_lipoprotein_level	3.03708866
9	MP0003191_abnormal_cellular_cholesterol	3.00226786
10	MP0003705_abnormal_hypodermis_morpholog	2.80587156
11	MP0005666_abnormal_adipose_tissue	2.73413558
12	MP0002971_abnormal_brown_adipose	2.32426446
13	MP0003868_abnormal_feces_composition	2.16829551
14	MP0003329_amyloid_beta_deposits	2.14819849
15	MP0005058_abnormal_lysosome_morphology	2.12178531
16	MP0004185_abnormal_adipocyte_glucose	2.08108430
17	MP0003195_calcinosis	2.06678216
18	MP0005375_adipose_tissue_phenotype	2.00072778
19	MP0004130_abnormal_muscle_cell	1.99282968
20	MP0005451_abnormal_body_composition	1.98540408
21	MP0002118_abnormal_lipid_homeostasis	1.91856978
22	MP0001666_abnormal_nutrient_absorption	1.84900811
23	MP0003879_abnormal_hair_cell	1.76793885
24	MP0005332_abnormal_amino_acid	1.72378050
25	MP0003690_abnormal_glial_cell	1.71112192
26	MP0009780_abnormal_chondrocyte_physiolo	1.66762060
27	MP0000604_amyloidosis	1.63460873
28	MP0000609_abnormal_liver_physiology	1.62559718
29	MP0008438_abnormal_cutaneous_collagen	1.60728191
30	MP0000566_synostosis	1.60336121
31	MP0001661_extended_life_span	1.48606408
32	MP0003252_abnormal_bile_duct	1.44380407
33	MP0000003_abnormal_adipose_tissue	1.43022805
34	MP0003566_abnormal_cell_adhesion	1.37256393
35	MP0004272_abnormal_basement_membrane	1.33590969
36	MP0005409_darkened_coat_color	1.33010171
37	MP0003075_altered_response_to	1.32232999
38	MP0000751_myopathy	1.28129657
39	MP0005334_abnormal_fat_pad	1.26321162
40	MP0002089_abnormal_postnatal_growth/wei	1.26040455
41	MP0004858_abnormal_nervous_system	1.24006162
42	MP0002970_abnormal_white_adipose	1.23760737
43	MP0005584_abnormal_enzyme/coenzyme_acti	1.23601024
44	MP0004019_abnormal_vitamin_homeostasis	1.20445447
45	MP0009115_abnormal_fat_cell	1.18188917
46	MP0010368_abnormal_lymphatic_system	1.16809911
47	MP0005083_abnormal_biliary_tract	1.15635329
48	MP0004859_abnormal_synaptic_plasticity	1.15025257
49	MP0002876_abnormal_thyroid_physiology	1.11133651
50	MP0005535_abnormal_body_temperature	1.10359760
51	MP0004270_analgesia	1.04988082
52	MP0001849_ear_inflammation	1.04740773
53	MP0010234_abnormal_vibrissa_follicle	1.02545805
54	MP0003453_abnormal_keratinocyte_physiol	0.98760805
55	MP0005076_abnormal_cell_differentiation	0.97932034
56	MP0005257_abnormal_intraocular_pressure	0.97143065
57	MP0002138_abnormal_hepatobiliary_system	0.96772441
58	MP0006138_congestive_heart_failure	0.95482540
59	MP0003959_abnormal_lean_body	0.94428323
60	MP0000920_abnormal_myelination	0.94132270
61	MP0002249_abnormal_larynx_morphology	0.93912289
62	MP0005448_abnormal_energy_balance	0.93567170
63	MP0008260_abnormal_autophagy	0.91438570
64	MP0001915_intracranial_hemorrhage	0.90813723
65	MP0000678_abnormal_parathyroid_gland	0.85662835
66	MP0002078_abnormal_glucose_homeostasis	0.84948429
67	MP0005167_abnormal_blood-brain_barrier	0.84755686
68	MP0005319_abnormal_enzyme/_coenzyme	0.83743601
69	MP0003634_abnormal_glial_cell	0.83687586
70	MP0009643_abnormal_urine_homeostasis	0.83438028
71	MP0002909_abnormal_adrenal_gland	0.81944997
72	MP0001764_abnormal_homeostasis	0.81686122
73	MP0005023_abnormal_wound_healing	0.81512572
74	MP0000579_abnormal_nail_morphology	0.78948048
75	MP0002896_abnormal_bone_mineralization	0.78307018
76	MP0003011_delayed_dark_adaptation	0.76847490
77	MP0003172_abnormal_lysosome_physiology	0.75774039
78	MP0003186_abnormal_redox_activity	0.73706188
79	MP0000467_abnormal_esophagus_morphology	0.73384837
80	MP0003123_paternal_imprinting	0.72536649
81	MP0002796_impaired_skin_barrier	0.72509889
82	MP0009672_abnormal_birth_weight	0.71324123
83	MP0000598_abnormal_liver_morphology	0.71180113
84	MP0005452_abnormal_adipose_tissue	0.71093773
85	MP0004233_abnormal_muscle_weight	0.70057959
86	MP0002060_abnormal_skin_morphology	0.69663893
87	MP0008874_decreased_physiological_sensi	0.67081924
88	MP0000013_abnormal_adipose_tissue	0.65727260
89	MP0000747_muscle_weakness	0.63334779
90	MP0005423_abnormal_somatic_nervous	0.62308050
91	MP0003633_abnormal_nervous_system	0.62273126
92	MP0009053_abnormal_anal_canal	0.61544657
93	MP0003632_abnormal_nervous_system	0.60302748
94	MP0003631_nervous_system_phenotype	0.57442130
95	MP0000762_abnormal_tongue_morphology	0.57408992
96	MP0004087_abnormal_muscle_fiber	0.54729192
97	MP0005647_abnormal_sex_gland	0.54203028
98	MP0002064_seizures	0.53984639
99	MP0003953_abnormal_hormone_level	0.53916126
100	MP0009642_abnormal_blood_homeostasis	0.52970312

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	6.82449163
2	Complement deficiency (HP:0004431)	6.71852241
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.10054483
4	Abnormality of complement system (HP:0005339)	5.57161213
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.52315527
6	Prolonged partial thromboplastin time (HP:0003645)	4.79567111
7	Xanthomatosis (HP:0000991)	4.49635879
8	Systemic lupus erythematosus (HP:0002725)	4.33147415
9	Hypobetalipoproteinemia (HP:0003563)	4.23113846
10	Joint hemorrhage (HP:0005261)	4.09153733
11	Conjugated hyperbilirubinemia (HP:0002908)	3.91383062
12	Glomerulonephritis (HP:0000099)	3.81591390
13	Hypercholesterolemia (HP:0003124)	3.54928556
14	Hyperlipoproteinemia (HP:0010980)	3.46631041
15	Intrahepatic cholestasis (HP:0001406)	3.36726332
16	Hemorrhage of the eye (HP:0011885)	3.30546702
17	Hypoalphalipoproteinemia (HP:0003233)	3.21238938
18	Hypolipoproteinemia (HP:0010981)	3.19079827
19	Abnormality of the common coagulation pathway (HP:0010990)	3.03344784
20	Mitral stenosis (HP:0001718)	2.90059754
21	Abnormality of the intrinsic pathway (HP:0010989)	2.83352118
22	Myocardial infarction (HP:0001658)	2.80475752
23	Neurofibrillary tangles (HP:0002185)	2.78208242
24	Cerebral inclusion bodies (HP:0100314)	2.74826940
25	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.74029525
26	Hypertriglyceridemia (HP:0002155)	2.70980038
27	Epidermoid cyst (HP:0200040)	2.70675786
28	Back pain (HP:0003418)	2.69146140
29	Nephritis (HP:0000123)	2.68224051
30	Skin nodule (HP:0200036)	2.55658050
31	Abnormality of the Achilles tendon (HP:0005109)	2.54101859
32	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.51683869
33	Axonal loss (HP:0003447)	2.51255955
34	Acanthosis nigricans (HP:0000956)	2.49920927
35	Vertebral compression fractures (HP:0002953)	2.47551852
36	Vascular calcification (HP:0004934)	2.45528835
37	Spontaneous abortion (HP:0005268)	2.43112729
38	Abnormality of pyrimidine metabolism (HP:0004353)	2.38212660
39	Abnormal gallbladder physiology (HP:0012438)	2.35934979
40	Cholecystitis (HP:0001082)	2.35934979
41	Protrusio acetabuli (HP:0003179)	2.35141125
42	Cardiovascular calcification (HP:0011915)	2.26681146
43	Fat malabsorption (HP:0002630)	2.21900302
44	Abnormality of carpal bone ossification (HP:0006257)	2.16498529
45	Amyloidosis (HP:0011034)	2.15009172
46	Premature rupture of membranes (HP:0001788)	2.13035017
47	Hyperammonemia (HP:0001987)	2.12503503
48	Neonatal onset (HP:0003623)	2.11833096
49	Cholelithiasis (HP:0001081)	2.09803192
50	Cerebral aneurysm (HP:0004944)	2.08526542
51	Achilles tendon contracture (HP:0001771)	2.03378845
52	Distal upper limb amyotrophy (HP:0007149)	1.97716531
53	Upper limb amyotrophy (HP:0009129)	1.97716531
54	Hepatocellular carcinoma (HP:0001402)	1.92435984
55	Myokymia (HP:0002411)	1.86583369
56	Abnormal ossification of hand bones (HP:0005921)	1.86055511
57	Ulnar bowing (HP:0003031)	1.85500992
58	Retinal atrophy (HP:0001105)	1.84307419
59	Rickets (HP:0002748)	1.84060505
60	Abnormal gallbladder morphology (HP:0012437)	1.82771248
61	Bronchomalacia (HP:0002780)	1.81720101
62	Short nail (HP:0001799)	1.78069401
63	Neonatal death (HP:0003811)	1.78035929
64	Recurrent gram-negative bacterial infections (HP:0005420)	1.76879532
65	Flat acetabular roof (HP:0003180)	1.75528798
66	Purpura (HP:0000979)	1.75500935
67	Mucopolysacchariduria (HP:0008155)	1.74304856
68	Urinary glycosaminoglycan excretion (HP:0003541)	1.74304856
69	Cervical subluxation (HP:0003308)	1.72533010
70	Abnormal delivery (HP:0001787)	1.72481985
71	Distal lower limb muscle weakness (HP:0009053)	1.71578813
72	Shallow orbits (HP:0000586)	1.70805697
73	Atrophic scars (HP:0001075)	1.70417505
74	Hyperacusis (HP:0010780)	1.69589556
75	Obstructive sleep apnea (HP:0002870)	1.68579607
76	Abnormality of polysaccharide metabolism (HP:0011012)	1.64960021
77	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.64960021
78	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.64960021
79	Atrioventricular block (HP:0001678)	1.64937668
80	Stridor (HP:0010307)	1.64897916
81	Growth hormone excess (HP:0000845)	1.64862145
82	Oligomenorrhea (HP:0000876)	1.64697906
83	Insulin resistance (HP:0000855)	1.63325798
84	Delayed CNS myelination (HP:0002188)	1.63017646
85	Pathologic fracture (HP:0002756)	1.62480243
86	Supranuclear gaze palsy (HP:0000605)	1.62465089
87	Elevated alkaline phosphatase (HP:0003155)	1.62320795
88	Steatorrhea (HP:0002570)	1.61311016
89	Advanced eruption of teeth (HP:0006288)	1.60848668
90	Reticulocytosis (HP:0001923)	1.60653367
91	Generalized aminoaciduria (HP:0002909)	1.60161068
92	Paraparesis (HP:0002385)	1.60062613
93	Turricephaly (HP:0000262)	1.59967949
94	Increased connective tissue (HP:0009025)	1.57094164
95	Hyperbilirubinemia (HP:0002904)	1.57012715
96	Esophageal varix (HP:0002040)	1.55943902
97	Hydroxyprolinuria (HP:0003080)	1.55069798
98	Abnormality of proline metabolism (HP:0010907)	1.55069798
99	Abnormality of the gallbladder (HP:0005264)	1.54598949
100	Abnormality of nucleobase metabolism (HP:0010932)	1.54426017

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.26188367
2	SIK1	3.69629163
3	RIPK1	3.40790508
4	ERN1	3.00538838
5	ICK	2.86219733
6	TESK1	2.28148615
7	PRPF4B	2.19835049
8	ARAF	2.19726960
9	MST1R	2.19329510
10	EPHA2	2.12155096
11	SMG1	2.07053161
12	IRAK3	2.02748769
13	LATS2	1.94674333
14	FGFR4	1.94522722
15	CAMK1D	1.94093666
16	EEF2K	1.66101919
17	NTRK1	1.58707943
18	NME2	1.56840857
19	PDGFRA	1.55917601
20	PRKD3	1.54073817
21	PIM2	1.48382287
22	PKN2	1.46672489
23	EPHA4	1.46544973
24	LMTK2	1.46322360
25	CAMK1G	1.32185587
26	DDR2	1.31583649
27	PTK2	1.30555159
28	PDPK1	1.30285440
29	EPHB2	1.28237357
30	PDK2	1.24180617
31	MET	1.21162316
32	ABL2	1.19221636
33	NTRK3	1.17849760
34	KSR2	1.14010257
35	MAP3K9	1.11190650
36	PAK6	1.05996684
37	MTOR	0.99542095
38	CAMKK1	0.99074913
39	PAK4	0.98292462
40	TAOK2	0.97833831
41	MAP3K11	0.96192835
42	PRKAA2	0.93537792
43	MAP3K6	0.93402893
44	CDK12	0.93252363
45	TYRO3	0.92106861
46	SCYL2	0.83249199
47	MARK2	0.81827731
48	DAPK2	0.81739774
49	BRAF	0.80393220
50	TESK2	0.80109981
51	CAMK2G	0.79651663
52	STK38	0.77744455
53	TTN	0.76471918
54	PTK6	0.75954398
55	CAMK1	0.75791120
56	RET	0.73403890
57	LIMK1	0.73001376
58	MAP3K1	0.70951855
59	BMX	0.70636586
60	CAMK2B	0.70542826
61	PHKG1	0.69168140
62	PHKG2	0.69168140
63	MAP3K3	0.68372132
64	MAPK12	0.68292584
65	MAPK11	0.66692761
66	MAPKAPK3	0.66580065
67	TGFBR2	0.66394358
68	PDK1	0.64371554
69	PRKG2	0.58948782
70	RPS6KA2	0.58711700
71	PRKAA1	0.58233243
72	AKT2	0.57393721
73	PRKD2	0.57019487
74	TAOK1	0.56576327
75	MAP3K2	0.55273113
76	NEK6	0.54238448
77	MAP2K1	0.54117159
78	SGK494	0.54086238
79	SGK223	0.54086238
80	CDK15	0.54084282
81	GRK5	0.52277460
82	SGK3	0.52263574
83	DAPK1	0.49600981
84	DAPK3	0.49558586
85	MARK1	0.48763040
86	CDK11A	0.48648631
87	MAPK4	0.47374017
88	CDK6	0.47322449
89	CAMKK2	0.46576521
90	CDK18	0.46380757
91	PRKACG	0.46166205
92	CDC42BPA	0.44913939
93	MAP2K4	0.44897800
94	UHMK1	0.44387320
95	PAK2	0.43156408
96	MOS	0.42801570
97	BRSK1	0.42356839
98	GSK3A	0.41707748
99	EPHB1	0.40014432
100	MAP2K2	0.39230471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.50820465
2	Complement and coagulation cascades_Homo sapiens_hsa04610	3.27421705
3	Phenylalanine metabolism_Homo sapiens_hsa00360	2.94869788
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.81555439
5	PPAR signaling pathway_Homo sapiens_hsa03320	2.52127065
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.51995146
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.38862175
8	Fatty acid degradation_Homo sapiens_hsa00071	2.26676397
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.24131043
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.21564528
11	Tyrosine metabolism_Homo sapiens_hsa00350	2.20341094
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.08371919
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.01357462
14	Histidine metabolism_Homo sapiens_hsa00340	2.01215380
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.00569803
16	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.99376489
17	Retinol metabolism_Homo sapiens_hsa00830	1.92169571
18	Bile secretion_Homo sapiens_hsa04976	1.89893378
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88071233
20	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.83563572
21	Prion diseases_Homo sapiens_hsa05020	1.79970564
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.77430406
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.73196672
24	Caffeine metabolism_Homo sapiens_hsa00232	1.72620637
25	* Pyruvate metabolism_Homo sapiens_hsa00620	1.67021122
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.67018776
27	* Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.59770521
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.59651418
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.56364471
30	* Biosynthesis of amino acids_Homo sapiens_hsa01230	1.56322045
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.53143686
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.42887302
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.39851812
34	Sulfur relay system_Homo sapiens_hsa04122	1.33794664
35	* Carbon metabolism_Homo sapiens_hsa01200	1.33469540
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.30978229
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.29762700
38	Arginine and proline metabolism_Homo sapiens_hsa00330	1.27246024
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15809174
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.09532306
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.09398217
42	Fatty acid elongation_Homo sapiens_hsa00062	1.07091721
43	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.02924187
44	Other glycan degradation_Homo sapiens_hsa00511	1.02256948
45	Butanoate metabolism_Homo sapiens_hsa00650	1.02094967
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99984883
47	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.96243339
48	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.95385545
49	Pentose phosphate pathway_Homo sapiens_hsa00030	0.94590145
50	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.92315570
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92151467
52	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.90746010
53	Propanoate metabolism_Homo sapiens_hsa00640	0.87616334
54	AMPK signaling pathway_Homo sapiens_hsa04152	0.83200732
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.81735806
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.79442879
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78979953
58	Peroxisome_Homo sapiens_hsa04146	0.78697938
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75610736
60	Galactose metabolism_Homo sapiens_hsa00052	0.75067066
61	ABC transporters_Homo sapiens_hsa02010	0.73015528
62	Glucagon signaling pathway_Homo sapiens_hsa04922	0.61481835
63	Insulin signaling pathway_Homo sapiens_hsa04910	0.59987179
64	Lysine degradation_Homo sapiens_hsa00310	0.54840147
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53155394
66	Insulin resistance_Homo sapiens_hsa04931	0.52748048
67	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.52001183
68	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.46816909
69	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.46063384
70	ECM-receptor interaction_Homo sapiens_hsa04512	0.45423908
71	Sulfur metabolism_Homo sapiens_hsa00920	0.43007498
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42359839
73	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42252282
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38581126
75	Folate biosynthesis_Homo sapiens_hsa00790	0.37901861
76	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.36854969
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36493261
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.31850480
79	Amoebiasis_Homo sapiens_hsa05146	0.30928470
80	* Metabolic pathways_Homo sapiens_hsa01100	0.30639733
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.29209383
82	Mineral absorption_Homo sapiens_hsa04978	0.28007784
83	Lysosome_Homo sapiens_hsa04142	0.25949601
84	Long-term potentiation_Homo sapiens_hsa04720	0.24259336
85	Vibrio cholerae infection_Homo sapiens_hsa05110	0.22992680
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22664998
87	Glutathione metabolism_Homo sapiens_hsa00480	0.22042714
88	Pertussis_Homo sapiens_hsa05133	0.20638025
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.20274958
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.18900400
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17904936
92	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.13761192
93	Focal adhesion_Homo sapiens_hsa04510	0.13256144
94	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.13225110
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.12296125
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.11661424
97	Estrogen signaling pathway_Homo sapiens_hsa04915	0.10632835
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.10582681
99	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.10434819
100	Protein digestion and absorption_Homo sapiens_hsa04974	0.10434766

PC

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »