PCBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51154414
2* L-phenylalanine catabolic process (GO:0006559)7.51154414
3* erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18990451
4* L-phenylalanine metabolic process (GO:0006558)7.18990451
5* aromatic amino acid family catabolic process (GO:0009074)6.52208830
6tryptophan catabolic process (GO:0006569)5.77249117
7indole-containing compound catabolic process (GO:0042436)5.77249117
8indolalkylamine catabolic process (GO:0046218)5.77249117
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.72836689
10glyoxylate metabolic process (GO:0046487)5.67118081
11bile acid biosynthetic process (GO:0006699)5.58567004
12kynurenine metabolic process (GO:0070189)5.57711982
13cysteine metabolic process (GO:0006534)5.55795551
14tryptophan metabolic process (GO:0006568)5.54764505
15sulfur amino acid catabolic process (GO:0000098)5.24201390
16alpha-linolenic acid metabolic process (GO:0036109)5.18948816
17urea metabolic process (GO:0019627)5.15064122
18urea cycle (GO:0000050)5.15064122
19high-density lipoprotein particle remodeling (GO:0034375)5.08057531
20negative regulation of fibrinolysis (GO:0051918)4.96231003
21serine family amino acid catabolic process (GO:0009071)4.95370659
22tyrosine metabolic process (GO:0006570)4.89722786
23peptidyl-glutamic acid carboxylation (GO:0017187)4.87437977
24protein carboxylation (GO:0018214)4.87437977
25* aromatic amino acid family metabolic process (GO:0009072)4.82343901
26bile acid metabolic process (GO:0008206)4.79682052
27regulation of fibrinolysis (GO:0051917)4.79576650
28nitrogen cycle metabolic process (GO:0071941)4.78404466
29lysine metabolic process (GO:0006553)4.78101156
30lysine catabolic process (GO:0006554)4.78101156
31homocysteine metabolic process (GO:0050667)4.74467157
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71477626
33complement activation, alternative pathway (GO:0006957)4.61297869
34cellular ketone body metabolic process (GO:0046950)4.58470011
35regulation of protein activation cascade (GO:2000257)4.57044875
36* alpha-amino acid catabolic process (GO:1901606)4.50513794
37reverse cholesterol transport (GO:0043691)4.46768149
38regulation of cholesterol esterification (GO:0010872)4.44546274
39coenzyme catabolic process (GO:0009109)4.43028888
40acylglycerol homeostasis (GO:0055090)4.38003981
41triglyceride homeostasis (GO:0070328)4.38003981
42amino-acid betaine metabolic process (GO:0006577)4.36510622
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33855072
44indolalkylamine metabolic process (GO:0006586)4.32942482
45protein-lipid complex remodeling (GO:0034368)4.30911045
46macromolecular complex remodeling (GO:0034367)4.30911045
47plasma lipoprotein particle remodeling (GO:0034369)4.30911045
48regulation of triglyceride catabolic process (GO:0010896)4.30148160
49regulation of complement activation (GO:0030449)4.24397720
50* cellular amino acid catabolic process (GO:0009063)4.23726204
51bile acid and bile salt transport (GO:0015721)4.23399457
52cellular modified amino acid catabolic process (GO:0042219)4.22942792
53aldehyde catabolic process (GO:0046185)4.22210249
54phospholipid efflux (GO:0033700)4.17957130
55negative regulation of cholesterol transport (GO:0032375)4.14806390
56negative regulation of sterol transport (GO:0032372)4.14806390
57regulation of mitochondrial translation (GO:0070129)4.14077901
58glutamate metabolic process (GO:0006536)4.10139188
59serine family amino acid metabolic process (GO:0009069)4.09221563
60drug catabolic process (GO:0042737)4.09004262
61glycine metabolic process (GO:0006544)4.08339208
62intestinal cholesterol absorption (GO:0030299)4.04221226
63benzene-containing compound metabolic process (GO:0042537)4.02925435
64cellular biogenic amine catabolic process (GO:0042402)4.02029090
65amine catabolic process (GO:0009310)4.02029090
66imidazole-containing compound metabolic process (GO:0052803)3.96786494
67ketone body metabolic process (GO:1902224)3.96325928
68epoxygenase P450 pathway (GO:0019373)3.94710812
69short-chain fatty acid metabolic process (GO:0046459)3.91342845
70cellular glucuronidation (GO:0052695)3.90506323
71drug transmembrane transport (GO:0006855)3.83974056
72phenylpropanoid metabolic process (GO:0009698)3.83898523
73plasma lipoprotein particle clearance (GO:0034381)3.83301051
74serine family amino acid biosynthetic process (GO:0009070)3.79918428
75* organic acid catabolic process (GO:0016054)3.78593748
76* carboxylic acid catabolic process (GO:0046395)3.78593748
77cholesterol efflux (GO:0033344)3.78014370
78ATP synthesis coupled proton transport (GO:0015986)3.77282025
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77282025
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76438544
81arginine metabolic process (GO:0006525)3.70685064
82respiratory electron transport chain (GO:0022904)3.67214676
83cofactor catabolic process (GO:0051187)3.66090972
84urate metabolic process (GO:0046415)3.65237547
85uronic acid metabolic process (GO:0006063)3.64963510
86glucuronate metabolic process (GO:0019585)3.64963510
87daunorubicin metabolic process (GO:0044597)3.63592686
88polyketide metabolic process (GO:0030638)3.63592686
89doxorubicin metabolic process (GO:0044598)3.63592686
90ethanol oxidation (GO:0006069)3.62721942
91aspartate family amino acid catabolic process (GO:0009068)3.61916516
92electron transport chain (GO:0022900)3.61915626
93monocarboxylic acid catabolic process (GO:0072329)3.56826494
94plasma lipoprotein particle assembly (GO:0034377)3.54833991
95fibrinolysis (GO:0042730)3.51832231
96dicarboxylic acid biosynthetic process (GO:0043650)3.50664927
97acetyl-CoA metabolic process (GO:0006084)3.49758213
98regulation of bile acid biosynthetic process (GO:0070857)3.49075153
99fatty acid oxidation (GO:0019395)3.48016955
100low-density lipoprotein particle remodeling (GO:0034374)3.47808325
101drug metabolic process (GO:0017144)3.47688556
102fatty acid beta-oxidation (GO:0006635)3.47110560
103regulation of cholesterol homeostasis (GO:2000188)3.46498200
104exogenous drug catabolic process (GO:0042738)3.45892603
105blood coagulation, intrinsic pathway (GO:0007597)3.45453375
106positive regulation of triglyceride lipase activity (GO:0061365)3.44231836
107positive regulation of lipoprotein lipase activity (GO:0051006)3.44231836
108fatty acid catabolic process (GO:0009062)3.43009924
109cholesterol homeostasis (GO:0042632)3.41775761
110lipid oxidation (GO:0034440)3.40768280
111flavonoid metabolic process (GO:0009812)3.38340168
112sterol homeostasis (GO:0055092)3.37343960
113NADH metabolic process (GO:0006734)3.34178426
114aminoglycoside antibiotic metabolic process (GO:0030647)3.22183779
115xenobiotic catabolic process (GO:0042178)3.18088908
116branched-chain amino acid catabolic process (GO:0009083)3.16468096
117ethanol metabolic process (GO:0006067)3.14106951
118proline metabolic process (GO:0006560)3.12581005
119water-soluble vitamin biosynthetic process (GO:0042364)3.10468135
120protein complex biogenesis (GO:0070271)3.09303269
121oxaloacetate metabolic process (GO:0006107)3.07605004
122cellular aldehyde metabolic process (GO:0006081)3.03787831
123omega-hydroxylase P450 pathway (GO:0097267)3.02859548
124oxidative phosphorylation (GO:0006119)3.01756699
125tricarboxylic acid cycle (GO:0006099)2.99463075
126L-serine metabolic process (GO:0006563)2.89854451
127heme transport (GO:0015886)2.89155666
128mitochondrial respiratory chain complex assembly (GO:0033108)2.82694580
129protein maturation by protein folding (GO:0022417)2.81003441
130regulation of plasminogen activation (GO:0010755)2.78750394
131gluconeogenesis (GO:0006094)2.78266531
132ribosomal small subunit biogenesis (GO:0042274)2.77920694
133biotin metabolic process (GO:0006768)2.77455346
134primary alcohol catabolic process (GO:0034310)2.76854200
135cytochrome complex assembly (GO:0017004)2.75160762
136L-ascorbic acid metabolic process (GO:0019852)2.73399168
137positive regulation of cellular amine metabolic process (GO:0033240)2.71583138
138regulation of oxidative phosphorylation (GO:0002082)2.69258269
139primary alcohol metabolic process (GO:0034308)2.68093573
140hexose biosynthetic process (GO:0019319)2.67736509
141fatty acid homeostasis (GO:0055089)2.66633727
142monosaccharide biosynthetic process (GO:0046364)2.64954059
143fructose metabolic process (GO:0006000)2.63733418
144proline biosynthetic process (GO:0006561)2.63550657
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63110364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.03523916
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.86318616
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.51733752
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.17903593
5* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10853446
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08313649
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.54230995
8* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91923268
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.65696701
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31519062
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91924381
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75374001
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.69896400
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.63531112
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58234588
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45024533
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44718414
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36989237
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28591941
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27724708
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.21982762
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04786775
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01936976
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3726715
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98449084
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.95265830
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92424963
28DCP1A_22483619_ChIP-Seq_HELA_Human1.80547624
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75755489
30GATA1_22025678_ChIP-Seq_K562_Human1.72527566
31XRN2_22483619_ChIP-Seq_HELA_Human1.69666321
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68975007
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65601600
34GABP_19822575_ChIP-Seq_HepG2_Human1.62967374
35HTT_18923047_ChIP-ChIP_STHdh_Human1.61579774
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59598798
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58237265
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57750148
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57735051
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56098718
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47038721
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.46251567
43CLOCK_20551151_ChIP-Seq_293T_Human1.42758598
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41907661
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.38622306
46AR_21909140_ChIP-Seq_LNCAP_Human1.35179348
47TTF2_22483619_ChIP-Seq_HELA_Human1.33786394
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26556144
49CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25356954
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24409961
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22711200
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20757538
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20193023
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19469118
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15262085
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14508649
57TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14187514
58RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13566762
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.11221945
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10401560
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10062469
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.09930707
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09305437
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07243836
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.05493836
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04236617
67KDM5A_27292631_Chip-Seq_BREAST_Human1.03512577
68GATA4_25053715_ChIP-Seq_YYC3_Human1.00729173
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00466260
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00012337
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99674425
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97894691
73SOX17_20123909_ChIP-Seq_XEN_Mouse0.97496376
74VDR_23849224_ChIP-Seq_CD4+_Human0.96797399
75KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96344344
76FOXP3_21729870_ChIP-Seq_TREG_Human0.95127331
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94633337
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94285597
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93974497
80EOMES_21245162_ChIP-Seq_HESCs_Human0.92645485
81NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92318240
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92090714
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91747202
84TFEB_21752829_ChIP-Seq_HELA_Human0.91491630
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91366303
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89195829
87ATF3_27146783_Chip-Seq_COLON_Human0.88345660
88TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87697080
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87633784
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87210319
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86973469
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85807481
93* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85703658
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81787287
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81324550
96AR_20517297_ChIP-Seq_VCAP_Human0.80270030
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.77094980
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75989169
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75555310
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74938184
101RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74893750
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.73459125
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73319209
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72908314
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72447206
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68969357
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66615342
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.66519906
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.66115738
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65787984
111TAF15_26573619_Chip-Seq_HEK293_Human0.65517510
112RARB_24833708_ChIP-Seq_LIVER_Mouse0.64306831
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63786047
114* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62942117
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62842896
116ERG_20517297_ChIP-Seq_VCAP_Human0.62676161
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.61438795
118* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61411281
119ZNF263_19887448_ChIP-Seq_K562_Human0.60212712
120* ESET_19884257_ChIP-Seq_ESCs_Mouse0.60013577
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.59465930
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.57628907
123MYC_19915707_ChIP-ChIP_AK7_Human0.57457377
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56638820
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55981336
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55981336
127BCAT_22108803_ChIP-Seq_LS180_Human0.55549649
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.54674880
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54661986
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.54645535
131* P53_21459846_ChIP-Seq_SAOS-2_Human0.54478572
132SOX2_20726797_ChIP-Seq_SW620_Human0.54185066
133GATA6_25053715_ChIP-Seq_YYC3_Human0.52189119
134PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.52170602
135NCOR_22424771_ChIP-Seq_293T_Human0.51461324
136STAT1_17558387_ChIP-Seq_HELA_Human0.51392224
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.51171660
138CEBPB_22108803_ChIP-Seq_LS180_Human0.50914176
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50050145
140* TAF2_19829295_ChIP-Seq_ESCs_Human0.48692900
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.48661094
142LXR_22292898_ChIP-Seq_THP-1_Human0.48253904
143* CBP_21632823_ChIP-Seq_H3396_Human0.48083061
144SOX2_22085726_ChIP-Seq_NPCs_Mouse0.46746489
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46400042
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.44699074
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44392668
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.43748446
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.43212519
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42598458
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.42560435
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.42519609
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.42283339
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42191288
155OCT4_20526341_ChIP-Seq_ESCs_Human0.42189662
156NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.41318725
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.40839265
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.39959162
159IRF1_19129219_ChIP-ChIP_H3396_Human0.39810426
160* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.39566013
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38338117
162SPI1_26923725_Chip-Seq_HPCs_Mouse0.38016015
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.37543143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.07948772
2MP0005360_urolithiasis7.18545463
3MP0005365_abnormal_bile_salt6.23946280
4MP0005085_abnormal_gallbladder_physiolo6.19003953
5MP0008875_abnormal_xenobiotic_pharmacok4.82111149
6MP0003806_abnormal_nucleotide_metabolis3.86348533
7MP0003252_abnormal_bile_duct3.74254985
8MP0005083_abnormal_biliary_tract3.58446104
9MP0003195_calcinosis3.28276917
10MP0010329_abnormal_lipoprotein_level3.24458816
11MP0001666_abnormal_nutrient_absorption3.11956342
12* MP0005332_abnormal_amino_acid2.89233233
13MP0009840_abnormal_foam_cell2.68502325
14MP0010234_abnormal_vibrissa_follicle2.48918760
15MP0004019_abnormal_vitamin_homeostasis2.34412056
16MP0003868_abnormal_feces_composition2.29718226
17MP0002138_abnormal_hepatobiliary_system2.29714646
18MP0002118_abnormal_lipid_homeostasis2.06025854
19MP0003123_paternal_imprinting1.99251564
20MP0000609_abnormal_liver_physiology1.95833761
21MP0003191_abnormal_cellular_cholesterol1.84521683
22MP0001764_abnormal_homeostasis1.82554498
23MP0005319_abnormal_enzyme/_coenzyme1.73292562
24* MP0009643_abnormal_urine_homeostasis1.60714946
25MP0005220_abnormal_exocrine_pancreas1.59014644
26MP0005584_abnormal_enzyme/coenzyme_acti1.50010598
27MP0005084_abnormal_gallbladder_morpholo1.49707719
28MP0009697_abnormal_copulation1.48027390
29MP0002132_abnormal_respiratory_system1.44154160
30MP0005451_abnormal_body_composition1.35018193
31MP0003186_abnormal_redox_activity1.34607886
32MP0005636_abnormal_mineral_homeostasis1.34329453
33MP0002163_abnormal_gland_morphology1.24122578
34MP0006036_abnormal_mitochondrial_physio1.21840885
35MP0004043_abnormal_pH_regulation1.16133639
36MP0001756_abnormal_urination1.14741646
37* MP0002078_abnormal_glucose_homeostasis1.14075045
38MP0002876_abnormal_thyroid_physiology1.11265268
39MP0000598_abnormal_liver_morphology1.04892284
40MP0002837_dystrophic_cardiac_calcinosis1.03869017
41MP0001727_abnormal_embryo_implantation1.03350656
42MP0003011_delayed_dark_adaptation1.03283167
43MP0005330_cardiomyopathy1.02345900
44MP0002822_catalepsy0.99883328
45MP0003656_abnormal_erythrocyte_physiolo0.97795111
46MP0005535_abnormal_body_temperature0.96588787
47MP0003122_maternal_imprinting0.96072804
48* MP0009642_abnormal_blood_homeostasis0.93181657
49MP0001881_abnormal_mammary_gland0.90548901
50MP0001944_abnormal_pancreas_morphology0.89343964
51MP0003879_abnormal_hair_cell0.87215538
52MP0005647_abnormal_sex_gland0.86437579
53MP0002928_abnormal_bile_duct0.80226356
54MP0003283_abnormal_digestive_organ0.79969321
55MP0000604_amyloidosis0.79430578
56MP0009763_increased_sensitivity_to0.79108011
57MP0010030_abnormal_orbit_morphology0.77420703
58MP0008469_abnormal_protein_level0.77415178
59MP0005448_abnormal_energy_balance0.76690628
60MP0005376_homeostasis/metabolism_phenot0.76540658
61MP0009764_decreased_sensitivity_to0.76390178
62MP0002693_abnormal_pancreas_physiology0.75655429
63MP0000678_abnormal_parathyroid_gland0.74880113
64MP0004233_abnormal_muscle_weight0.73896397
65MP0006035_abnormal_mitochondrial_morpho0.73315440
66MP0000639_abnormal_adrenal_gland0.71258565
67* MP0003953_abnormal_hormone_level0.71149467
68MP0009765_abnormal_xenobiotic_induced0.70879527
69MP0000516_abnormal_urinary_system0.70768723
70MP0005367_renal/urinary_system_phenotyp0.70768723
71MP0005334_abnormal_fat_pad0.70348641
72MP0005670_abnormal_white_adipose0.68996117
73MP0005666_abnormal_adipose_tissue0.68824077
74MP0000538_abnormal_urinary_bladder0.68111239
75MP0000003_abnormal_adipose_tissue0.68003415
76MP0003786_premature_aging0.67479819
77MP0003638_abnormal_response/metabolism_0.67143404
78MP0001661_extended_life_span0.66608572
79MP0001765_abnormal_ion_homeostasis0.66483705
80MP0004264_abnormal_extraembryonic_tissu0.65128130
81MP0003959_abnormal_lean_body0.64441055
82MP0002971_abnormal_brown_adipose0.62662327
83MP0005266_abnormal_metabolism0.62521966
84MP0005379_endocrine/exocrine_gland_phen0.61150523
85MP0005375_adipose_tissue_phenotype0.60887445
86MP0002136_abnormal_kidney_physiology0.60845668
87MP0001905_abnormal_dopamine_level0.59973195
88MP0003075_altered_response_to0.58355943
89MP0008872_abnormal_physiological_respon0.57884000
90MP0003693_abnormal_embryo_hatching0.57052747
91MP0000681_abnormal_thyroid_gland0.56610743
92MP0010368_abnormal_lymphatic_system0.56498428
93MP0010386_abnormal_urinary_bladder0.56414783
94MP0000230_abnormal_systemic_arterial0.56395937
95MP0002254_reproductive_system_inflammat0.55130279
96MP0004185_abnormal_adipocyte_glucose0.55074475
97MP0000013_abnormal_adipose_tissue0.54306733
98MP0000343_altered_response_to0.53906142
99MP0002160_abnormal_reproductive_system0.53554643
100MP0003705_abnormal_hypodermis_morpholog0.53482090
101MP0002234_abnormal_pharynx_morphology0.53250101
102MP0003646_muscle_fatigue0.53224894
103MP0002269_muscular_atrophy0.52368754
104MP0000358_abnormal_cell_content/0.52206621
105MP0003941_abnormal_skin_development0.51788196
106MP0005187_abnormal_penis_morphology0.51630584
107MP0003329_amyloid_beta_deposits0.50632621
108MP0006276_abnormal_autonomic_nervous0.50141685
109* MP0005408_hypopigmentation0.49469607
110MP0003315_abnormal_perineum_morphology0.49206586
111MP0005410_abnormal_fertilization0.48985823
112MP0005058_abnormal_lysosome_morphology0.48433819
113MP0000566_synostosis0.48412188
114MP0002909_abnormal_adrenal_gland0.45511771
115MP0004782_abnormal_surfactant_physiolog0.45073297
116MP0004130_abnormal_muscle_cell0.43737415
117MP0005395_other_phenotype0.42442197
118MP0003724_increased_susceptibility_to0.39084567
119MP0003183_abnormal_peptide_metabolism0.38596959
120MP0009672_abnormal_birth_weight0.38203135
121MP0003718_maternal_effect0.36129966
122MP0008873_increased_physiological_sensi0.35255753
123MP0005646_abnormal_pituitary_gland0.35044677
124MP0008874_decreased_physiological_sensi0.33106966
125MP0002970_abnormal_white_adipose0.32404951
126MP0002069_abnormal_eating/drinking_beha0.32282072
127MP0008961_abnormal_basal_metabolism0.31887979
128MP0009053_abnormal_anal_canal0.31647111
129MP0003690_abnormal_glial_cell0.30063667
130MP0002168_other_aberrant_phenotype0.29985768
131MP0009379_abnormal_foot_pigmentation0.29674863
132MP0009780_abnormal_chondrocyte_physiolo0.29641651
133MP0005452_abnormal_adipose_tissue0.27625310
134MP0002135_abnormal_kidney_morphology0.26242589
135MP0002090_abnormal_vision0.26196100

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of aromatic amino acid family metabolism (HP:0004338)7.22843573
2Intrahepatic cholestasis (HP:0001406)6.51690702
3Deep venous thrombosis (HP:0002625)6.20007146
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.98129858
5Prolonged partial thromboplastin time (HP:0003645)5.75275235
6Hypobetalipoproteinemia (HP:0003563)5.62471752
7Xanthomatosis (HP:0000991)5.47796059
8Hypoglycemic coma (HP:0001325)4.68037970
9Hyperlipoproteinemia (HP:0010980)4.65064524
10Ketosis (HP:0001946)4.64627744
11Hyperammonemia (HP:0001987)4.31888242
12Complement deficiency (HP:0004431)4.30953989
13Hyperglycinemia (HP:0002154)4.30298349
14Abnormality of the common coagulation pathway (HP:0010990)4.15137823
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09435685
16Joint hemorrhage (HP:0005261)4.08809596
17Hypolipoproteinemia (HP:0010981)4.07935047
18Hyperglycinuria (HP:0003108)4.05259110
19Fat malabsorption (HP:0002630)4.04674233
20Abnormality of the intrinsic pathway (HP:0010989)3.94795251
21Conjugated hyperbilirubinemia (HP:0002908)3.94520227
22Ketoacidosis (HP:0001993)3.92263356
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.89600745
24Abnormality of serine family amino acid metabolism (HP:0010894)3.85366451
25Abnormality of glycine metabolism (HP:0010895)3.85366451
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.84004006
27Acute necrotizing encephalopathy (HP:0006965)3.77006425
28Abnormality of methionine metabolism (HP:0010901)3.70555122
29Epidermoid cyst (HP:0200040)3.69719204
30Abnormal mitochondria in muscle tissue (HP:0008316)3.65350113
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64872577
32Gout (HP:0001997)3.63630261
33Hypoglycemic seizures (HP:0002173)3.50144741
34Abnormality of fatty-acid metabolism (HP:0004359)3.48170272
35Mitochondrial inheritance (HP:0001427)3.46549624
36Hypoalphalipoproteinemia (HP:0003233)3.43108337
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37600057
38Abnormality of pyrimidine metabolism (HP:0004353)3.30177653
39Hepatocellular necrosis (HP:0001404)3.25250868
40Hyperbilirubinemia (HP:0002904)3.21068251
41Progressive macrocephaly (HP:0004481)3.18535035
42Abnormality of nucleobase metabolism (HP:0010932)3.17965502
43Increased CSF lactate (HP:0002490)3.17132077
44Abnormality of purine metabolism (HP:0004352)3.11859427
45Steatorrhea (HP:0002570)3.07377018
46Hyperinsulinemic hypoglycemia (HP:0000825)3.06839155
47Delayed CNS myelination (HP:0002188)3.03025028
48Abnormality of complement system (HP:0005339)3.02736995
49Increased hepatocellular lipid droplets (HP:0006565)3.00915941
50Cerebral edema (HP:0002181)3.00317334
51Lipid accumulation in hepatocytes (HP:0006561)2.96586119
52Metabolic acidosis (HP:0001942)2.94940267
53Lethargy (HP:0001254)2.93544237
54Renal Fanconi syndrome (HP:0001994)2.92378849
55Hypercholesterolemia (HP:0003124)2.91947543
56Abnormality of serum amino acid levels (HP:0003112)2.89918720
57Abnormality of glycolysis (HP:0004366)2.89555695
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87181876
59Dicarboxylic aciduria (HP:0003215)2.87181876
60Generalized aminoaciduria (HP:0002909)2.85614903
61Late onset (HP:0003584)2.84783641
62Increased serum pyruvate (HP:0003542)2.79230830
63Symptomatic seizures (HP:0011145)2.72173567
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71828672
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71828672
66Increased intramyocellular lipid droplets (HP:0012240)2.68728823
67Reduced antithrombin III activity (HP:0001976)2.67794101
68Hepatocellular carcinoma (HP:0001402)2.64568343
69Increased muscle lipid content (HP:0009058)2.58240168
70Irritability (HP:0000737)2.57449599
71Skin nodule (HP:0200036)2.56356513
72Lactic acidosis (HP:0003128)2.55574151
73Abnormality of urine glucose concentration (HP:0011016)2.53117763
74Glycosuria (HP:0003076)2.53117763
75Respiratory failure (HP:0002878)2.51984977
76Proximal tubulopathy (HP:0000114)2.43773712
77Enlarged kidneys (HP:0000105)2.43191079
78Alkalosis (HP:0001948)2.41680810
79Vomiting (HP:0002013)2.36389881
80Hyperglycemia (HP:0003074)2.34223944
81Brushfield spots (HP:0001088)2.34171880
82Spontaneous abortion (HP:0005268)2.33916624
83Hyperuricemia (HP:0002149)2.32103044
84Increased purine levels (HP:0004368)2.32103044
85Hypokinesia (HP:0002375)2.31192885
86Abnormal gallbladder morphology (HP:0012437)2.30440928
87Vascular calcification (HP:0004934)2.30076272
88Pancreatitis (HP:0001733)2.29999637
89Increased serum lactate (HP:0002151)2.29170166
90Neonatal onset (HP:0003623)2.29117645
91Malnutrition (HP:0004395)2.28122835
92Type I transferrin isoform profile (HP:0003642)2.27903892
93Exercise intolerance (HP:0003546)2.27696674
94Hypochromic microcytic anemia (HP:0004840)2.18873871
95Testicular atrophy (HP:0000029)2.18300899
96Abnormal urine phosphate concentration (HP:0012599)2.18154187
97Acute encephalopathy (HP:0006846)2.17381836
98Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15431179
99Myocardial infarction (HP:0001658)2.12111202
100Sensorimotor neuropathy (HP:0007141)2.11686437
101Cholelithiasis (HP:0001081)2.09253991
102Abnormal gallbladder physiology (HP:0012438)2.08815544
103Cholecystitis (HP:0001082)2.08815544
104Congenital malformation of the right heart (HP:0011723)2.08211016
105Double outlet right ventricle (HP:0001719)2.08211016
106Systemic lupus erythematosus (HP:0002725)2.06828286
107Abnormality of the pancreatic islet cells (HP:0006476)2.06730957
108Abnormality of endocrine pancreas physiology (HP:0012093)2.06730957
109Acanthocytosis (HP:0001927)2.06384636
110Opisthotonus (HP:0002179)2.04738344
111Reticulocytopenia (HP:0001896)2.03646820
112Mitral stenosis (HP:0001718)2.02852368
113Spastic diplegia (HP:0001264)2.02630197
114Rickets (HP:0002748)2.02160746
115Menorrhagia (HP:0000132)2.01025128
116Macrocytic anemia (HP:0001972)2.00591658
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98390787
118Cardiovascular calcification (HP:0011915)1.97757082
119Hepatic necrosis (HP:0002605)1.96653393
120Vacuolated lymphocytes (HP:0001922)1.96347219
121Hyperphosphaturia (HP:0003109)1.96086589
122CNS demyelination (HP:0007305)1.95584145
123Degeneration of anterior horn cells (HP:0002398)1.95421319
124Abnormality of the anterior horn cell (HP:0006802)1.95421319
125Methylmalonic aciduria (HP:0012120)1.92702415
126Glomerulonephritis (HP:0000099)1.92668392
127Abnormal enzyme/coenzyme activity (HP:0012379)1.90879219
128Abnormality of vitamin metabolism (HP:0100508)1.90356002
129Hydroxyprolinuria (HP:0003080)1.89513566
130Abnormality of proline metabolism (HP:0010907)1.89513566
131Abnormality of renal resorption (HP:0011038)1.88066719
132Renal cortical cysts (HP:0000803)1.88046997
133Abnormality of the gallbladder (HP:0005264)1.86279221
134Prolonged neonatal jaundice (HP:0006579)1.85520316
135Amyloidosis (HP:0011034)1.84845760
136Acute hepatic failure (HP:0006554)1.82053549
137Hypophosphatemic rickets (HP:0004912)1.75331073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.55183214
2INSRR4.36022423
3VRK23.95678483
4ERN13.93699188
5EPHA23.60195610
6FGFR43.38840462
7TAOK33.34810588
8SIK13.30611467
9MAPK153.06532428
10WNK32.84206401
11MAP3K122.83630562
12MST42.78788197
13PIK3CG2.68007743
14EIF2AK12.67257275
15FRK2.49754462
16WNK42.44996873
17ERBB42.24089835
18FLT32.15938445
19PBK2.14334727
20PDK22.11050969
21NME12.08557066
22MAP2K42.04982459
23TESK11.98539644
24MST1R1.93698914
25BUB11.67923479
26LMTK21.65171831
27PHKG11.64066184
28PHKG21.64066184
29ILK1.55750079
30NEK11.54629865
31LIMK11.47781414
32PKN21.43408682
33MAPK111.38549538
34PIM21.37785435
35LRRK21.34336151
36MAP3K21.29262337
37PAK41.29196144
38STK38L1.29097529
39VRK11.28541658
40MAPKAPK31.26902150
41DAPK21.21054837
42PTK61.14998885
43TRIM281.13157102
44ABL21.11637642
45MAP2K21.09638312
46DAPK31.06240072
47PINK11.05550535
48IRAK31.04365232
49SCYL21.04347499
50DAPK11.03874251
51RPS6KB21.00396337
52NTRK10.99967016
53STK160.96898004
54PRKCI0.96250082
55LATS10.95419493
56NEK90.94522855
57MUSK0.93270262
58ZAK0.92399207
59SMG10.89217199
60STK390.87991981
61JAK20.87336666
62GRK50.86984545
63PRKD30.86561277
64TYK20.86400777
65PTK20.85845762
66MAP2K60.85679567
67MAP3K30.84652442
68PRKAA20.83268875
69MAP2K10.82424765
70CAMK2D0.79951035
71DYRK1B0.79479175
72STK240.78673794
73MAP3K10.78492445
74AKT20.78461401
75PASK0.75221959
76TTK0.74720313
77OBSCN0.74713761
78PRKG20.73889048
79PRKCZ0.73498209
80BRSK10.73427437
81MET0.73368513
82EPHA30.73162864
83PRKACG0.73029668
84TRIB30.72858916
85EPHB20.72133563
86CAMK2G0.71198245
87MAP4K20.68689678
88GSK3A0.68086628
89PLK30.67461784
90GRK60.67447756
91ERBB20.67423256
92TAOK20.65398978
93CSNK2A20.64621432
94IRAK10.63927579
95MAPK40.63567259
96AURKA0.63530619
97TSSK60.62515372
98PRKAA10.62400404
99ARAF0.62372756
100MAP3K110.61965960
101SGK4940.61722977
102SGK2230.61722977
103MAP2K30.60150379
104OXSR10.59550616
105CSNK1G10.57812267
106KDR0.57481573
107PAK30.56973372
108NME20.55924916
109CSNK2A10.54927342
110GRK70.54349667
111STK40.54144040
112PLK10.53484502
113FGFR20.51278799
114TLK10.50243481
115NTRK30.49124358
116SGK20.48613732
117CSNK1G30.48611177
118CSNK1A1L0.47956251
119MAP3K70.47315876
120RET0.46199180
121TIE10.45020170
122ICK0.44597235
123BRSK20.43918742
124TBK10.43754463
125MYLK0.42706666
126IRAK20.41815331
127EIF2AK30.41701584
128GRK10.41460346
129CSNK1G20.41199643
130JAK10.41083704
131KSR20.40912907
132BRAF0.40505153
133AURKB0.40395680
134PRKCG0.39890694
135HIPK20.38714906
136IGF1R0.38519697
137CSNK1A10.38357591
138CDK80.36802099
139PRKACA0.36782917
140TAF10.35423212
141CSNK1E0.35274970
142AKT30.34971634
143MAPKAPK50.34639569
144FER0.34457130
145SGK30.34384913
146PAK10.33971438
147PRKCE0.32687002
148PRKCA0.31844588
149ZAP700.30959927
150PDPK10.30415223
151PDK30.30220971
152PDK40.30220971
153PIK3CA0.30132291
154ADRBK20.29893498
155CSK0.26883949
156MAP3K40.25807568
157ADRBK10.25395781
158PRKCQ0.24712499
159MAP3K50.23713566
160RPS6KB10.23616417
161RIPK10.22997853
162BMPR1B0.21785788
163MAPK120.21571263
164MAP3K60.19902257

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15785418
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31068776
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03743546
4Nitrogen metabolism_Homo sapiens_hsa009102.98865019
5Tryptophan metabolism_Homo sapiens_hsa003802.77264586
6Arginine biosynthesis_Homo sapiens_hsa002202.75531159
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61209925
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58504214
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55258023
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51335134
11Fatty acid degradation_Homo sapiens_hsa000712.44090572
12Complement and coagulation cascades_Homo sapiens_hsa046102.32275318
13Butanoate metabolism_Homo sapiens_hsa006502.31160893
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24560298
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.22524412
16Peroxisome_Homo sapiens_hsa041462.12330184
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10131547
18Propanoate metabolism_Homo sapiens_hsa006402.04887985
19Histidine metabolism_Homo sapiens_hsa003401.97814384
20Sulfur metabolism_Homo sapiens_hsa009201.89850328
21Ribosome_Homo sapiens_hsa030101.82417325
22Chemical carcinogenesis_Homo sapiens_hsa052041.80288486
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78521236
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74698495
25Fatty acid metabolism_Homo sapiens_hsa012121.72897072
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71450699
27Proteasome_Homo sapiens_hsa030501.71272139
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.70552098
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.69717108
30Phenylalanine metabolism_Homo sapiens_hsa003601.69607346
31beta-Alanine metabolism_Homo sapiens_hsa004101.67811065
32Selenocompound metabolism_Homo sapiens_hsa004501.64734680
33PPAR signaling pathway_Homo sapiens_hsa033201.64205636
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59947151
35Folate biosynthesis_Homo sapiens_hsa007901.59286730
36Tyrosine metabolism_Homo sapiens_hsa003501.56606938
37Pyruvate metabolism_Homo sapiens_hsa006201.54534440
38Retinol metabolism_Homo sapiens_hsa008301.51111575
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49237714
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45456660
41Bile secretion_Homo sapiens_hsa049761.42547137
42Fat digestion and absorption_Homo sapiens_hsa049751.38388261
43Fatty acid elongation_Homo sapiens_hsa000621.37747211
44Caffeine metabolism_Homo sapiens_hsa002321.34404507
45Starch and sucrose metabolism_Homo sapiens_hsa005001.33427351
46Staphylococcus aureus infection_Homo sapiens_hsa051501.25350480
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.21416086
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.14016589
49Carbon metabolism_Homo sapiens_hsa012001.13871126
50Steroid biosynthesis_Homo sapiens_hsa001001.13376743
51Biosynthesis of amino acids_Homo sapiens_hsa012301.10733657
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09900914
53ABC transporters_Homo sapiens_hsa020101.09802155
54Arginine and proline metabolism_Homo sapiens_hsa003301.09208750
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96410289
56Vitamin digestion and absorption_Homo sapiens_hsa049770.92277241
57Sulfur relay system_Homo sapiens_hsa041220.91870292
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89836490
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89691260
60Glycerolipid metabolism_Homo sapiens_hsa005610.78515779
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77949765
62RNA polymerase_Homo sapiens_hsa030200.76292424
63Glutathione metabolism_Homo sapiens_hsa004800.75354755
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75275034
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72895149
66Lysine degradation_Homo sapiens_hsa003100.70903741
67Protein export_Homo sapiens_hsa030600.69037390
68Vitamin B6 metabolism_Homo sapiens_hsa007500.68433671
69Vibrio cholerae infection_Homo sapiens_hsa051100.66557363
70Cardiac muscle contraction_Homo sapiens_hsa042600.65693790
71Collecting duct acid secretion_Homo sapiens_hsa049660.63930558
72Pyrimidine metabolism_Homo sapiens_hsa002400.62794322
73One carbon pool by folate_Homo sapiens_hsa006700.62318232
74Metabolic pathways_Homo sapiens_hsa011000.59915499
75Pentose phosphate pathway_Homo sapiens_hsa000300.53166141
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50217261
77Mineral absorption_Homo sapiens_hsa049780.50074817
78N-Glycan biosynthesis_Homo sapiens_hsa005100.49896461
79Oxidative phosphorylation_Homo sapiens_hsa001900.47759590
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42896291
81Fructose and mannose metabolism_Homo sapiens_hsa000510.42003682
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39209233
83Galactose metabolism_Homo sapiens_hsa000520.39019121
84Sphingolipid metabolism_Homo sapiens_hsa006000.37966743
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36628477
86Base excision repair_Homo sapiens_hsa034100.36330277
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34825664
88Linoleic acid metabolism_Homo sapiens_hsa005910.34022171
89Parkinsons disease_Homo sapiens_hsa050120.33443344
90Purine metabolism_Homo sapiens_hsa002300.31948799
91DNA replication_Homo sapiens_hsa030300.31747549
92Mismatch repair_Homo sapiens_hsa034300.31362120
93Prion diseases_Homo sapiens_hsa050200.31196829
94Lysosome_Homo sapiens_hsa041420.30273512
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24919763
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23699775
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19692586
98Insulin resistance_Homo sapiens_hsa049310.18608432
99Glucagon signaling pathway_Homo sapiens_hsa049220.18318179
100Alzheimers disease_Homo sapiens_hsa050100.17020187
101Fatty acid biosynthesis_Homo sapiens_hsa000610.15567889
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.15155332
103Regulation of autophagy_Homo sapiens_hsa041400.12198904
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.09052661
105Pancreatic secretion_Homo sapiens_hsa049720.08297602
106Protein digestion and absorption_Homo sapiens_hsa049740.07424557
107Huntingtons disease_Homo sapiens_hsa050160.00744958
108Other glycan degradation_Homo sapiens_hsa00511-0.1046227
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0993161
110Insulin signaling pathway_Homo sapiens_hsa04910-0.0845635
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0828180
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0696883
113Insulin secretion_Homo sapiens_hsa04911-0.0619100
114Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0395614
115AMPK signaling pathway_Homo sapiens_hsa04152-0.0390659
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0204674
117Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0121340
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0031076

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