PCBD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.05178824
2viral transcription (GO:0019083)5.71003736
3ribosomal small subunit assembly (GO:0000028)5.51951281
4translational termination (GO:0006415)5.51645885
5negative regulation of cytosolic calcium ion concentration (GO:0051481)5.19682086
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.00130956
7ribosomal small subunit biogenesis (GO:0042274)4.91237445
8translational elongation (GO:0006414)4.89240611
9cotranslational protein targeting to membrane (GO:0006613)4.87568263
10protein targeting to ER (GO:0045047)4.87321376
11protein localization to endoplasmic reticulum (GO:0070972)4.64578536
12piRNA metabolic process (GO:0034587)4.63038109
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.60148565
14behavioral response to nicotine (GO:0035095)4.44791556
15ribosomal large subunit biogenesis (GO:0042273)4.28121203
16tryptophan metabolic process (GO:0006568)4.20381167
17viral life cycle (GO:0019058)4.13438670
18indolalkylamine metabolic process (GO:0006586)4.12187086
19cellular protein complex disassembly (GO:0043624)4.09714173
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.97764586
21kynurenine metabolic process (GO:0070189)3.96862496
22vascular smooth muscle contraction (GO:0014829)3.90536961
23translational initiation (GO:0006413)3.87655322
24water-soluble vitamin biosynthetic process (GO:0042364)3.86624509
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84270485
26histone mRNA catabolic process (GO:0071044)3.80667466
27pre-miRNA processing (GO:0031054)3.76650974
28inositol phosphate catabolic process (GO:0071545)3.73128385
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71210975
30response to pheromone (GO:0019236)3.68064528
31regulation of energy homeostasis (GO:2000505)3.54761474
32ncRNA catabolic process (GO:0034661)3.51016096
33protein complex disassembly (GO:0043241)3.46498375
34neural tube formation (GO:0001841)3.46062769
35DNA methylation involved in gamete generation (GO:0043046)3.44352311
36polyol catabolic process (GO:0046174)3.43116205
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43094072
38heme biosynthetic process (GO:0006783)3.41630444
39L-phenylalanine metabolic process (GO:0006558)3.40661411
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.40661411
41kidney morphogenesis (GO:0060993)3.39815800
42hyperosmotic salinity response (GO:0042538)3.39505063
43detection of light stimulus involved in visual perception (GO:0050908)3.38241489
44detection of light stimulus involved in sensory perception (GO:0050962)3.38241489
45oxidative phosphorylation (GO:0006119)3.38077092
46axoneme assembly (GO:0035082)3.34700742
47spinal cord motor neuron differentiation (GO:0021522)3.33691864
48respiratory electron transport chain (GO:0022904)3.32578318
49fucose catabolic process (GO:0019317)3.32553307
50L-fucose metabolic process (GO:0042354)3.32553307
51L-fucose catabolic process (GO:0042355)3.32553307
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30409712
53macromolecular complex disassembly (GO:0032984)3.24376934
54protein targeting to membrane (GO:0006612)3.24054699
55electron transport chain (GO:0022900)3.24010143
56protein K11-linked deubiquitination (GO:0035871)3.22714828
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21722992
58microtubule polymerization or depolymerization (GO:0031109)3.21675874
59translation (GO:0006412)3.20558766
60maturation of SSU-rRNA (GO:0030490)3.17712302
61telomere maintenance via semi-conservative replication (GO:0032201)3.14562256
62calcium ion import (GO:0070509)3.10488567
63ATP synthesis coupled proton transport (GO:0015986)3.09742319
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09742319
65protein complex biogenesis (GO:0070271)3.09558960
66heme metabolic process (GO:0042168)3.08724240
67regulation of respiratory burst (GO:0060263)3.06552022
68photoreceptor cell maintenance (GO:0045494)3.05875269
69amine catabolic process (GO:0009310)3.05526030
70cellular biogenic amine catabolic process (GO:0042402)3.05526030
71neuronal action potential (GO:0019228)3.03887915
72mitochondrial respiratory chain complex assembly (GO:0033108)3.02862601
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01876277
74cellular ketone body metabolic process (GO:0046950)2.98838362
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97820904
76L-phenylalanine catabolic process (GO:0006559)2.97820904
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.96101447
78ubiquinone biosynthetic process (GO:0006744)2.95688578
79response to caffeine (GO:0031000)2.94342361
80sulfation (GO:0051923)2.93183570
81negative regulation of telomere maintenance (GO:0032205)2.92004165
82fatty acid transmembrane transport (GO:1902001)2.91979723
83sulfur amino acid catabolic process (GO:0000098)2.90226193
84meiotic chromosome segregation (GO:0045132)2.87037413
85regulation of hexokinase activity (GO:1903299)2.85621721
86regulation of glucokinase activity (GO:0033131)2.85621721
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85566963
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85563087
89gamma-aminobutyric acid transport (GO:0015812)2.84749735
90nuclear-transcribed mRNA catabolic process (GO:0000956)2.84403225
91indole-containing compound metabolic process (GO:0042430)2.83203808
92pentose metabolic process (GO:0019321)2.83136023
93nonmotile primary cilium assembly (GO:0035058)2.81193325
94protein-cofactor linkage (GO:0018065)2.78869287
95response to interferon-beta (GO:0035456)2.78129503
96proline biosynthetic process (GO:0006561)2.77078356
97platelet dense granule organization (GO:0060155)2.76158788
98ketone body metabolic process (GO:1902224)2.75763001
99positive regulation of glycolytic process (GO:0045821)2.75314587
100limb bud formation (GO:0060174)2.74975392
101histone-serine phosphorylation (GO:0035404)2.74543769
102mRNA catabolic process (GO:0006402)2.73643924
103regulation of timing of cell differentiation (GO:0048505)2.73506910
104protein polyglutamylation (GO:0018095)2.73113668
105cytochrome complex assembly (GO:0017004)2.72735065
106replication fork processing (GO:0031297)2.72725215
107telomere maintenance via recombination (GO:0000722)2.71404075
108DNA strand elongation involved in DNA replication (GO:0006271)2.70210839
109epithelial cilium movement (GO:0003351)2.68700309
110double-strand break repair via homologous recombination (GO:0000724)2.68415050
111ubiquinone metabolic process (GO:0006743)2.68414674
112cysteine metabolic process (GO:0006534)2.68292171
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67991113
114recombinational repair (GO:0000725)2.67789115
115glyoxylate metabolic process (GO:0046487)2.66998337
116ribonucleoprotein complex biogenesis (GO:0022613)2.66929408
117oxidative demethylation (GO:0070989)2.66457875
118histone H2A acetylation (GO:0043968)2.66136867
119histone mRNA metabolic process (GO:0008334)2.65407291
120DNA demethylation (GO:0080111)2.64628483
121kinetochore assembly (GO:0051382)2.64137313
122proline transport (GO:0015824)2.62756421
123photoreceptor cell development (GO:0042461)2.61826899
124DNA strand elongation (GO:0022616)2.60204633
125* pteridine-containing compound biosynthetic process (GO:0042559)2.59443004
126RNA catabolic process (GO:0006401)2.58799731
127mitochondrial calcium ion transport (GO:0006851)2.58444489
128DNA double-strand break processing (GO:0000729)2.57399477
129deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56545678
130regulation of cilium movement (GO:0003352)2.55888381
131proteasome assembly (GO:0043248)2.55696432
132cornea development in camera-type eye (GO:0061303)2.55444359
133rRNA methylation (GO:0031167)2.55194875
134meiotic cell cycle (GO:0051321)2.54257018
135porphyrin-containing compound biosynthetic process (GO:0006779)2.53521210
136aromatic amino acid family catabolic process (GO:0009074)2.52695813
137low-density lipoprotein particle remodeling (GO:0034374)2.51959595
138multicellular organism reproduction (GO:0032504)2.51490871
139relaxation of cardiac muscle (GO:0055119)2.51119270
140relaxation of smooth muscle (GO:0044557)2.50618637
141synaptic transmission, cholinergic (GO:0007271)2.49394902
142L-methionine salvage (GO:0071267)2.49166185
143L-methionine biosynthetic process (GO:0071265)2.49166185
144amino acid salvage (GO:0043102)2.49166185
145cell differentiation in spinal cord (GO:0021515)2.48427118
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48296068
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48296068
148rRNA modification (GO:0000154)2.48141313
149regulation of skeletal muscle contraction (GO:0014819)2.47422810
150regulation of hydrogen peroxide metabolic process (GO:0010310)2.46749400
151signal peptide processing (GO:0006465)2.45716027
152pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44173438
153cellular response to zinc ion (GO:0071294)2.41909660
154kinetochore organization (GO:0051383)2.40861067
155positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40328799
156respiratory chain complex IV assembly (GO:0008535)2.40078009
157pseudouridine synthesis (GO:0001522)2.39767352
158glycine metabolic process (GO:0006544)2.38847916
159cellular component biogenesis (GO:0044085)2.38672039
160disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.38242440
161killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.38242440
162pentose-phosphate shunt (GO:0006098)2.38136728
163flavonoid metabolic process (GO:0009812)2.37459812
164aldehyde catabolic process (GO:0046185)2.36534586
165aerobic respiration (GO:0009060)2.35879812
166proline metabolic process (GO:0006560)2.35756032
167GDP-mannose metabolic process (GO:0019673)2.34829865
168porphyrin-containing compound metabolic process (GO:0006778)2.34244450
169negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.33101454
170mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.31248403
171mitochondrial respiratory chain complex I assembly (GO:0032981)2.31248403
172NADH dehydrogenase complex assembly (GO:0010257)2.31248403
173positive regulation of protein homooligomerization (GO:0032464)2.31022623
174valine metabolic process (GO:0006573)2.29123777
175ethanol oxidation (GO:0006069)2.26004425
176regulation of cholesterol esterification (GO:0010872)2.25989746
177tetrapyrrole biosynthetic process (GO:0033014)2.24310200
178amino-acid betaine metabolic process (GO:0006577)2.24065600
179indolalkylamine catabolic process (GO:0046218)2.23702477
180tryptophan catabolic process (GO:0006569)2.23702477
181indole-containing compound catabolic process (GO:0042436)2.23702477
182mitotic recombination (GO:0006312)2.23296825
183formation of translation preinitiation complex (GO:0001731)2.21856979
184rRNA processing (GO:0006364)2.21410080
185establishment of protein localization to membrane (GO:0090150)2.21320904
186inner mitochondrial membrane organization (GO:0007007)2.21069508
187protein targeting (GO:0006605)2.20795664
188response to nitrosative stress (GO:0051409)2.18447196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74947305
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63795516
3ZNF274_21170338_ChIP-Seq_K562_Hela3.50183306
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.27835715
5E2F7_22180533_ChIP-Seq_HELA_Human3.18574638
6VDR_22108803_ChIP-Seq_LS180_Human3.17652618
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.04630680
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04600554
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.02458758
10GBX2_23144817_ChIP-Seq_PC3_Human2.84392231
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77739532
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52183928
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.47359870
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45521621
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39163030
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37657479
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36590607
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.35531059
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34845423
20FUS_26573619_Chip-Seq_HEK293_Human2.34283680
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33226339
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.31209815
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28932266
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28919002
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.27769183
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18257755
27EWS_26573619_Chip-Seq_HEK293_Human2.15583558
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.14132112
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.13606623
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12129106
31EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11852631
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.04775900
33TAF15_26573619_Chip-Seq_HEK293_Human1.98149070
34P300_19829295_ChIP-Seq_ESCs_Human1.97204141
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95500890
36ER_23166858_ChIP-Seq_MCF-7_Human1.94625798
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94543833
38* IGF1R_20145208_ChIP-Seq_DFB_Human1.94315371
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93901080
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92326982
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90277959
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89704207
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86769882
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86411132
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83961515
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82248413
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79474268
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78129683
49* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76908351
50EZH2_22144423_ChIP-Seq_EOC_Human1.76711422
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76584454
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76384856
53VDR_21846776_ChIP-Seq_THP-1_Human1.73933963
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73389891
55VDR_23849224_ChIP-Seq_CD4+_Human1.72448579
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71121747
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71121747
58XRN2_22483619_ChIP-Seq_HELA_Human1.70818574
59DCP1A_22483619_ChIP-Seq_HELA_Human1.69748884
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68253202
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63663371
62* TP53_22573176_ChIP-Seq_HFKS_Human1.62084476
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61129834
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61077316
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60557114
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58463479
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57594596
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.57273839
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54892771
70CBP_20019798_ChIP-Seq_JUKART_Human1.54892771
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53152789
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52322577
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51664103
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.50759957
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50190138
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49740902
77LXR_22158963_ChIP-Seq_LIVER_Mouse1.49533979
78* BCAT_22108803_ChIP-Seq_LS180_Human1.48681923
79FOXP3_21729870_ChIP-Seq_TREG_Human1.48428411
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47886597
81* STAT3_23295773_ChIP-Seq_U87_Human1.47744096
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.47263963
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46458450
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45262235
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45219411
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44623223
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44032903
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43904900
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42915959
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40128955
91HTT_18923047_ChIP-ChIP_STHdh_Human1.39818962
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39096083
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38794632
94* SPI1_23547873_ChIP-Seq_NB4_Human1.38681927
95* TCF4_23295773_ChIP-Seq_U87_Human1.38623585
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38426868
97GABP_19822575_ChIP-Seq_HepG2_Human1.38266622
98NANOG_19829295_ChIP-Seq_ESCs_Human1.37854644
99SOX2_19829295_ChIP-Seq_ESCs_Human1.37854644
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37751798
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37592201
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.36733255
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.36570334
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36263131
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36121919
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35517117
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34777000
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34165979
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.32384943
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32384943
111TTF2_22483619_ChIP-Seq_HELA_Human1.32248272
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32094012
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31616908
114AR_25329375_ChIP-Seq_VCAP_Human1.31109835
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30438209
116* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30246224
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28185667
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.27907228
119IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27252797
120MYC_18940864_ChIP-ChIP_HL60_Human1.25468678
121RUNX2_22187159_ChIP-Seq_PCA_Human1.24583038
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.24577600
123SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23132415
124IRF1_19129219_ChIP-ChIP_H3396_Human1.22905372
125NCOR_22424771_ChIP-Seq_293T_Human1.22587987
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.22294590
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22129157
128* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21064339
129* MYC_22102868_ChIP-Seq_BL_Human1.20887931
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20769905
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20273398
132STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19777365
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.18967241
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18221880
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17539257
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17322170
137SCL_19346495_ChIP-Seq_HPC-7_Human1.16491983
138THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14904899
139FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14202626
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12697796
141CRX_20693478_ChIP-Seq_RETINA_Mouse1.12544096
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.12232806
143FLI1_21867929_ChIP-Seq_TH2_Mouse1.11944659
144IRF8_21731497_ChIP-ChIP_J774_Mouse1.10826866
145MAF_26560356_Chip-Seq_TH1_Human1.10735216
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10246571
147RUNX1_22412390_ChIP-Seq_EML_Mouse1.10194438
148VDR_24763502_ChIP-Seq_THP-1_Human1.09800481
149GATA1_22025678_ChIP-Seq_K562_Human1.09570158
150AR_20517297_ChIP-Seq_VCAP_Human1.09203522
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09124166
152GATA3_21878914_ChIP-Seq_MCF-7_Human1.09057036
153NOTCH1_21737748_ChIP-Seq_TLL_Human1.08987091
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07872095
155TCF4_22108803_ChIP-Seq_LS180_Human1.07741874
156* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07336547
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06330568
158BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05730509
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05104204
160* HOXB7_26014856_ChIP-Seq_BT474_Human1.04444587
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03275399
162REST_21632747_ChIP-Seq_MESCs_Mouse1.01789197
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01730689
164NANOG_18555785_Chip-Seq_ESCs_Mouse1.01400167
165MAF_26560356_Chip-Seq_TH2_Human1.00516719
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99711287
167LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99193487
168POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98603776
169RNF2_27304074_Chip-Seq_NSC_Mouse0.98298529
170ELK1_19687146_ChIP-ChIP_HELA_Human0.98064038
171* CTCF_26484167_Chip-Seq_Bcells_Mouse0.97863090
172PRDM14_20953172_ChIP-Seq_ESCs_Human0.96966370
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96565356
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96347591
175UTX_26944678_Chip-Seq_JUKART_Human0.95987254
176ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95868148
177MYC_19829295_ChIP-Seq_ESCs_Human0.95828078
178CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95606520
179ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95458094
180P53_22387025_ChIP-Seq_ESCs_Mouse0.94869296
181SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94409406
182STAT1_20625510_ChIP-Seq_HELA_Human0.94396600
183TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93393216
184STAT3_18555785_Chip-Seq_ESCs_Mouse0.93258106
185BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93160017
186DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93157363
187PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92330368
188EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92115990
189NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91331645
190E2F1_21310950_ChIP-Seq_MCF-7_Human0.91118635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.91129402
2MP0005360_urolithiasis3.79715209
3MP0002139_abnormal_hepatobiliary_system3.77011547
4MP0005423_abnormal_somatic_nervous3.71180525
5MP0003806_abnormal_nucleotide_metabolis3.43974211
6MP0000569_abnormal_digit_pigmentation3.21543890
7MP0005085_abnormal_gallbladder_physiolo3.11512114
8MP0005365_abnormal_bile_salt3.05396958
9MP0003724_increased_susceptibility_to2.74861969
10MP0005551_abnormal_eye_electrophysiolog2.66986595
11MP0003186_abnormal_redox_activity2.54070715
12MP0001986_abnormal_taste_sensitivity2.52569092
13MP0008875_abnormal_xenobiotic_pharmacok2.52082601
14MP0006072_abnormal_retinal_apoptosis2.22585833
15MP0003656_abnormal_erythrocyte_physiolo2.18132609
16MP0001835_abnormal_antigen_presentation2.17698175
17MP0004133_heterotaxia2.17052616
18MP0009840_abnormal_foam_cell2.16647810
19MP0004145_abnormal_muscle_electrophysio2.15534740
20MP0002837_dystrophic_cardiac_calcinosis2.14741989
21MP0003693_abnormal_embryo_hatching2.11639350
22MP0002735_abnormal_chemical_nociception2.09474857
23MP0002876_abnormal_thyroid_physiology2.08992299
24MP0000685_abnormal_immune_system2.03783681
25MP0002102_abnormal_ear_morphology2.02077553
26MP0006292_abnormal_olfactory_placode1.99979218
27MP0009785_altered_susceptibility_to1.99454617
28MP0008872_abnormal_physiological_respon1.97093824
29MP0008877_abnormal_DNA_methylation1.94903526
30MP0000490_abnormal_crypts_of1.93059998
31MP0003950_abnormal_plasma_membrane1.90529585
32MP0005253_abnormal_eye_physiology1.86069696
33MP0000015_abnormal_ear_pigmentation1.83802958
34MP0006036_abnormal_mitochondrial_physio1.83753226
35MP0003436_decreased_susceptibility_to1.83131912
36MP0005083_abnormal_biliary_tract1.79713734
37MP0004043_abnormal_pH_regulation1.78439978
38MP0000372_irregular_coat_pigmentation1.74634104
39MP0005671_abnormal_response_to1.71053548
40MP0001968_abnormal_touch/_nociception1.70393124
41MP0005025_abnormal_response_to1.69505374
42MP0004957_abnormal_blastocyst_morpholog1.69282747
43MP0004084_abnormal_cardiac_muscle1.69102024
44MP0005332_abnormal_amino_acid1.66693865
45MP0006276_abnormal_autonomic_nervous1.63877377
46MP0002638_abnormal_pupillary_reflex1.61831951
47MP0005397_hematopoietic_system_phenotyp1.61554972
48MP0001545_abnormal_hematopoietic_system1.61554972
49MP0009379_abnormal_foot_pigmentation1.58947453
50MP0010155_abnormal_intestine_physiology1.58525407
51MP0009745_abnormal_behavioral_response1.54705811
52MP0002166_altered_tumor_susceptibility1.54192962
53MP0001666_abnormal_nutrient_absorption1.53588440
54MP0003890_abnormal_embryonic-extraembry1.50921843
55MP0002396_abnormal_hematopoietic_system1.50262273
56MP0002138_abnormal_hepatobiliary_system1.50047864
57MP0002736_abnormal_nociception_after1.49807613
58MP0005319_abnormal_enzyme/_coenzyme1.48938420
59MP0002148_abnormal_hypersensitivity_rea1.47378135
60MP0003195_calcinosis1.47190139
61MP0005645_abnormal_hypothalamus_physiol1.45284970
62MP0005451_abnormal_body_composition1.44309861
63MP0003252_abnormal_bile_duct1.44220548
64MP0008775_abnormal_heart_ventricle1.43370790
65MP0004142_abnormal_muscle_tone1.43240639
66MP0009333_abnormal_splenocyte_physiolog1.42218909
67MP0003868_abnormal_feces_composition1.41017986
68MP0001485_abnormal_pinna_reflex1.40702345
69MP0003763_abnormal_thymus_physiology1.39597991
70MP0008469_abnormal_protein_level1.38047843
71MP0001800_abnormal_humoral_immune1.37681790
72MP0001764_abnormal_homeostasis1.35496668
73MP0005000_abnormal_immune_tolerance1.34399706
74MP0001853_heart_inflammation1.33727409
75MP0000609_abnormal_liver_physiology1.33474209
76MP0003136_yellow_coat_color1.33238308
77MP0010329_abnormal_lipoprotein_level1.32709917
78MP0010094_abnormal_chromosome_stability1.29957284
79MP0009643_abnormal_urine_homeostasis1.29806553
80MP0006082_CNS_inflammation1.28755873
81MP0009046_muscle_twitch1.28330505
82MP0003866_abnormal_defecation1.27628539
83MP0002398_abnormal_bone_marrow1.27528881
84MP0001845_abnormal_inflammatory_respons1.27114683
85MP0006035_abnormal_mitochondrial_morpho1.26795579
86MP0005464_abnormal_platelet_physiology1.26646112
87MP0002419_abnormal_innate_immunity1.26216326
88MP0005646_abnormal_pituitary_gland1.26207394
89MP0003191_abnormal_cellular_cholesterol1.26130230
90MP0004130_abnormal_muscle_cell1.25946350
91MP0002734_abnormal_mechanical_nocicepti1.25824099
92MP0002723_abnormal_immune_serum1.25239156
93MP0002452_abnormal_antigen_presenting1.24044874
94MP0002163_abnormal_gland_morphology1.23311736
95MP0000689_abnormal_spleen_morphology1.23028610
96MP0002405_respiratory_system_inflammati1.21873655
97MP0002938_white_spotting1.19865963
98MP0002006_tumorigenesis1.19830694
99MP0000383_abnormal_hair_follicle1.19527453
100MP0002420_abnormal_adaptive_immunity1.18695877
101MP0001819_abnormal_immune_cell1.18165503
102MP0002722_abnormal_immune_system1.17282227
103MP0004215_abnormal_myocardial_fiber1.17259664
104MP0005075_abnormal_melanosome_morpholog1.17172586
105MP0005584_abnormal_enzyme/coenzyme_acti1.16535817
106MP0004036_abnormal_muscle_relaxation1.16113479
107MP0009697_abnormal_copulation1.13284967
108MP0002272_abnormal_nervous_system1.12637880
109MP0000631_abnormal_neuroendocrine_gland1.11743860
110MP0000716_abnormal_immune_system1.11551610
111MP0003646_muscle_fatigue1.10740111
112MP0005058_abnormal_lysosome_morphology1.09691118
113MP0001486_abnormal_startle_reflex1.09612203
114MP0002429_abnormal_blood_cell1.08870301
115MP0005636_abnormal_mineral_homeostasis1.08716463
116MP0005387_immune_system_phenotype1.07884130
117MP0001790_abnormal_immune_system1.07884130
118MP0009763_increased_sensitivity_to1.05923673
119MP0001970_abnormal_pain_threshold1.05334690
120MP0008058_abnormal_DNA_repair1.05145172
121MP0004885_abnormal_endolymph1.04837080
122MP0001501_abnormal_sleep_pattern1.04549330
123MP0009764_decreased_sensitivity_to1.04271276
124MP0008057_abnormal_DNA_replication1.02968351
125MP0002095_abnormal_skin_pigmentation1.02785444
126MP0002019_abnormal_tumor_incidence1.02501414
127MP0000427_abnormal_hair_cycle1.01808138
128MP0001873_stomach_inflammation1.00652115
129MP0003718_maternal_effect1.00183351
130MP0000598_abnormal_liver_morphology0.99941133
131MP0000343_altered_response_to0.97748581
132MP0004019_abnormal_vitamin_homeostasis0.97482800
133MP0005379_endocrine/exocrine_gland_phen0.96702863
134MP0002118_abnormal_lipid_homeostasis0.95824091
135MP0005084_abnormal_gallbladder_morpholo0.95206941
136MP0004924_abnormal_behavior0.94126941
137MP0005386_behavior/neurological_phenoty0.94126941
138MP0002132_abnormal_respiratory_system0.92697551
139MP0004147_increased_porphyrin_level0.92064404
140MP0002160_abnormal_reproductive_system0.91744854
141MP0003011_delayed_dark_adaptation0.91342840
142MP0003077_abnormal_cell_cycle0.90829745
143MP0003878_abnormal_ear_physiology0.90649617
144MP0005377_hearing/vestibular/ear_phenot0.90649617
145MP0002693_abnormal_pancreas_physiology0.89430213
146MP0001529_abnormal_vocalization0.89313762
147MP0005174_abnormal_tail_pigmentation0.88454328
148MP0005220_abnormal_exocrine_pancreas0.87714601
149MP0003787_abnormal_imprinting0.87178690
150MP0000516_abnormal_urinary_system0.86595052
151MP0005367_renal/urinary_system_phenotyp0.86595052
152MP0004085_abnormal_heartbeat0.86534129
153MP0008961_abnormal_basal_metabolism0.86219001
154MP0005266_abnormal_metabolism0.85826255
155MP0002653_abnormal_ependyma_morphology0.85032798
156MP0002064_seizures0.84624785
157MP0005448_abnormal_energy_balance0.84312992
158MP0010386_abnormal_urinary_bladder0.83695518
159MP0001984_abnormal_olfaction0.83419364
160MP0004742_abnormal_vestibular_system0.82783529
161MP0005195_abnormal_posterior_eye0.82637435
162MP0002067_abnormal_sensory_capabilities0.82483584
163MP0002234_abnormal_pharynx_morphology0.81382253
164MP0002572_abnormal_emotion/affect_behav0.80985537
165MP0001663_abnormal_digestive_system0.80642905
166MP0005389_reproductive_system_phenotype0.80323909
167MP0001533_abnormal_skeleton_physiology0.79716488
168MP0000477_abnormal_intestine_morphology0.79523504
169MP0006054_spinal_hemorrhage0.79465908
170MP0000858_altered_metastatic_potential0.78584008
171MP0000465_gastrointestinal_hemorrhage0.77567225
172MP0001324_abnormal_eye_pigmentation0.75722514
173MP0005620_abnormal_muscle_contractility0.75614412
174MP0005670_abnormal_white_adipose0.75163012
175MP0004947_skin_inflammation0.75039235
176MP0008007_abnormal_cellular_replicative0.75002049
177MP0003453_abnormal_keratinocyte_physiol0.74607327
178MP0002090_abnormal_vision0.74417933
179MP0005171_absent_coat_pigmentation0.74211630
180MP0000538_abnormal_urinary_bladder0.73985867
181MP0005376_homeostasis/metabolism_phenot0.73891596
182MP0003698_abnormal_male_reproductive0.73539383
183MP0000749_muscle_degeneration0.71552805
184MP0002277_abnormal_respiratory_mucosa0.71280824
185MP0001929_abnormal_gametogenesis0.71034646

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.00694634
2Abnormality of cells of the erythroid lineage (HP:0012130)4.96202811
3Reticulocytopenia (HP:0001896)4.22197440
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.13491007
5Hip dysplasia (HP:0001385)4.00416973
6Pancreatic cysts (HP:0001737)3.93095789
7Hepatic necrosis (HP:0002605)3.87628216
8Carpal bone hypoplasia (HP:0001498)3.82333389
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81110018
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81110018
11Fetal akinesia sequence (HP:0001989)3.77117134
12Pancreatic fibrosis (HP:0100732)3.70446334
13Acute necrotizing encephalopathy (HP:0006965)3.66883537
14Molar tooth sign on MRI (HP:0002419)3.66243578
15Abnormality of midbrain morphology (HP:0002418)3.66243578
16Hip contracture (HP:0003273)3.60365832
17True hermaphroditism (HP:0010459)3.56062333
18Mitochondrial inheritance (HP:0001427)3.50836461
19Abnormal mitochondria in muscle tissue (HP:0008316)3.50463076
20Aplasia of the musculature (HP:0100854)3.49828986
21Hepatocellular necrosis (HP:0001404)3.46871516
22Acute encephalopathy (HP:0006846)3.46359594
23Generalized aminoaciduria (HP:0002909)3.42574755
24Congenital stationary night blindness (HP:0007642)3.35641312
25Nephronophthisis (HP:0000090)3.34684026
26Pallor (HP:0000980)3.28477459
27Increased CSF lactate (HP:0002490)3.28114053
28Macrocytic anemia (HP:0001972)3.25651546
29Aplasia/Hypoplasia involving the musculature (HP:0001460)3.23931399
30Hypoglycemic coma (HP:0001325)3.22309583
31Lipid accumulation in hepatocytes (HP:0006561)3.12980304
32Spinal muscular atrophy (HP:0007269)3.09428725
33Increased muscle lipid content (HP:0009058)3.08423247
34Abnormality of the renal medulla (HP:0100957)3.08058464
35Increased intramyocellular lipid droplets (HP:0012240)3.07232983
36Broad-based gait (HP:0002136)3.06689889
37Poikiloderma (HP:0001029)3.06659272
38Abnormality of the renal cortex (HP:0011035)3.03709423
39Muscle fiber splitting (HP:0003555)3.01344751
40Methylmalonic acidemia (HP:0002912)3.01009429
41Exertional dyspnea (HP:0002875)3.00040892
42Increased hepatocellular lipid droplets (HP:0006565)2.99761763
43Cerebral edema (HP:0002181)2.98430871
44Progressive macrocephaly (HP:0004481)2.90552604
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.89877316
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.84806160
47Abnormality of fatty-acid metabolism (HP:0004359)2.84729930
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83872008
49Disproportionate short-trunk short stature (HP:0003521)2.83582827
50Abnormality of the middle phalanges of the toes (HP:0010183)2.76853617
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72364334
52Lactic acidosis (HP:0003128)2.70157223
53Diaphragmatic weakness (HP:0009113)2.68724241
54Attenuation of retinal blood vessels (HP:0007843)2.65043221
55Pustule (HP:0200039)2.62989186
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62549897
57Dicarboxylic aciduria (HP:0003215)2.62549897
58Nausea (HP:0002018)2.60793750
59Increased serum lactate (HP:0002151)2.60536307
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59686037
61Renal Fanconi syndrome (HP:0001994)2.57914480
62Anencephaly (HP:0002323)2.57450327
63Short tibia (HP:0005736)2.54849346
64Methylmalonic aciduria (HP:0012120)2.54752189
65Stridor (HP:0010307)2.54683799
66Renal cortical cysts (HP:0000803)2.54180108
67Aplastic anemia (HP:0001915)2.53940296
68Supernumerary spleens (HP:0009799)2.51990242
69Abnormal hemoglobin (HP:0011902)2.51925803
70Small hand (HP:0200055)2.50166745
71Lethargy (HP:0001254)2.48698813
72Abnormality of urine glucose concentration (HP:0011016)2.48080559
73Glycosuria (HP:0003076)2.48080559
74Intrahepatic cholestasis (HP:0001406)2.46026412
75Recurrent bacterial skin infections (HP:0005406)2.45965463
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43943195
77Xanthomatosis (HP:0000991)2.43498140
78Respiratory failure (HP:0002878)2.43368331
79Hyperammonemia (HP:0001987)2.43194099
80Limited hip movement (HP:0008800)2.43109913
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39835982
82Barrel-shaped chest (HP:0001552)2.39541533
83Type II lissencephaly (HP:0007260)2.37309108
84Abnormal rod and cone electroretinograms (HP:0008323)2.36664091
85Hyperbilirubinemia (HP:0002904)2.35735963
86Tubular atrophy (HP:0000092)2.34998013
87Cystic liver disease (HP:0006706)2.34121005
88Hypoplasia of the pons (HP:0012110)2.32404484
89Prolonged partial thromboplastin time (HP:0003645)2.32024629
90Progressive inability to walk (HP:0002505)2.31649757
91Hypothermia (HP:0002045)2.30777464
92Hyperventilation (HP:0002883)2.29997076
93Abnormal drinking behavior (HP:0030082)2.29834848
94Polydipsia (HP:0001959)2.29834848
95Abnormality of the pons (HP:0007361)2.29313513
96Gaze-evoked nystagmus (HP:0000640)2.28793373
97Exercise intolerance (HP:0003546)2.25710158
98Increased serum ferritin (HP:0003281)2.25379194
99Reduced antithrombin III activity (HP:0001976)2.24752755
100Hypobetalipoproteinemia (HP:0003563)2.23768713
101Nonprogressive disorder (HP:0003680)2.22757321
102Pendular nystagmus (HP:0012043)2.22268601
103Abnormality of reticulocytes (HP:0004312)2.22096681
104Medial flaring of the eyebrow (HP:0010747)2.21941361
105Abolished electroretinogram (ERG) (HP:0000550)2.21383143
106Chronic hepatic failure (HP:0100626)2.20463445
107Ketosis (HP:0001946)2.19725299
108Difficulty running (HP:0009046)2.19689821
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18959535
110Abnormality of pyrimidine metabolism (HP:0004353)2.18694527
111Inability to walk (HP:0002540)2.17539456
112Abnormality of the vocal cords (HP:0008777)2.17008830
113Recurrent abscess formation (HP:0002722)2.14512747
114Hyperphosphaturia (HP:0003109)2.14161557
115Recurrent gram-negative bacterial infections (HP:0005420)2.12670876
116Decreased central vision (HP:0007663)2.11870201
117Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11596741
118Congenital, generalized hypertrichosis (HP:0004540)2.11439240
119Metabolic acidosis (HP:0001942)2.11165485
120Abnormality of the calf musculature (HP:0001430)2.08867805
121Vacuolated lymphocytes (HP:0001922)2.08786881
122Thrombocytosis (HP:0001894)2.06766821
123Elevated erythrocyte sedimentation rate (HP:0003565)2.06614051
124Sclerocornea (HP:0000647)2.06078167
125Hypoplasia of the odontoid process (HP:0003311)2.05162148
126Abnormality of T cell physiology (HP:0011840)2.03544177
127Furrowed tongue (HP:0000221)2.03454941
128Aplasia/Hypoplasia of the tongue (HP:0010295)2.03353065
1293-Methylglutaconic aciduria (HP:0003535)2.02304065
130Ketoacidosis (HP:0001993)2.00991072
131Respiratory difficulties (HP:0002880)2.00706346
132Congenital hepatic fibrosis (HP:0002612)2.00297238
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98530119
134Abnormality of alanine metabolism (HP:0010916)1.98530119
135Hyperalaninemia (HP:0003348)1.98530119
136Hyperlipoproteinemia (HP:0010980)1.98100650
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97789037
138Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96992830
139Microcytic anemia (HP:0001935)1.96112352
140Hyperglycinuria (HP:0003108)1.95779614
141Eczematoid dermatitis (HP:0000976)1.94025120
142Abnormality of iron homeostasis (HP:0011031)1.93976717
143Proximal tubulopathy (HP:0000114)1.93074114
144Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.92972530
145Absent/shortened dynein arms (HP:0200106)1.92880752
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.92880752
147Gowers sign (HP:0003391)1.92046773
148Type I transferrin isoform profile (HP:0003642)1.91774810
149Tubulointerstitial nephritis (HP:0001970)1.90384857
150Petechiae (HP:0000967)1.89222725
151Limb-girdle muscle atrophy (HP:0003797)1.89125938
152Ragged-red muscle fibers (HP:0003200)1.88739473
153Large for gestational age (HP:0001520)1.88709474
154Polyuria (HP:0000103)1.88535461
155Deep venous thrombosis (HP:0002625)1.87570349
156Abnormality of vitamin B metabolism (HP:0004340)1.87528776
157Optic disc pallor (HP:0000543)1.86985515
158IgM deficiency (HP:0002850)1.86598543
159Polycythemia (HP:0001901)1.85744300
160Vomiting (HP:0002013)1.83958569
161Hypolipoproteinemia (HP:0010981)1.82992687
162Abnormal biliary tract physiology (HP:0012439)1.81325010
163Bile duct proliferation (HP:0001408)1.81325010
164Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81006723
165Hypokinesia (HP:0002375)1.80581126
166Abnormality of serine family amino acid metabolism (HP:0010894)1.80055684
167Abnormality of glycine metabolism (HP:0010895)1.80055684
168Oral leukoplakia (HP:0002745)1.79411980
169Calf muscle hypertrophy (HP:0008981)1.79241635
170Muscle hypertrophy of the lower extremities (HP:0008968)1.78477700
171Fat malabsorption (HP:0002630)1.78426846
172Abnormality of transition element cation homeostasis (HP:0011030)1.77820223
173Recurrent skin infections (HP:0001581)1.76693585
174Abnormality of methionine metabolism (HP:0010901)1.76690947
175Hand muscle atrophy (HP:0009130)1.76237964
176Postaxial foot polydactyly (HP:0001830)1.76190447
177CNS demyelination (HP:0007305)1.75198444
178Down-sloping shoulders (HP:0200021)1.75174713
179Increased corneal curvature (HP:0100692)1.75096617
180Keratoconus (HP:0000563)1.75096617
181Abnormality of nucleobase metabolism (HP:0010932)1.74890166
182Urticaria (HP:0001025)1.74636906
183Abnormality of the intrinsic pathway (HP:0010989)1.74310985
184Poor head control (HP:0002421)1.74292961
185Prolonged bleeding time (HP:0003010)1.73182444
186Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72966074
187Abnormality of sulfur amino acid metabolism (HP:0004339)1.70591277
188Delayed CNS myelination (HP:0002188)1.70346340
189Chronic otitis media (HP:0000389)1.69951859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.24870140
2NME24.77387220
3BMPR1B3.19995244
4PIM22.89891311
5ADRBK22.84594506
6BCKDK2.80030600
7NUAK12.68543923
8STK392.57474631
9ZAK2.53443761
10WNK42.52815742
11TESK22.43594864
12MAP3K112.34349544
13OXSR12.32864277
14ACVR1B2.19885858
15TAOK32.19577530
16MAP4K22.19273220
17TLK12.17480395
18FLT32.16555816
19OBSCN2.16410988
20STK162.16126743
21ERN12.15457979
22GRK12.13767056
23MAP4K12.13263921
24INSRR2.02099723
25KDR1.99430227
26TEC1.96404725
27TNIK1.94383431
28WNK31.93558279
29TBK11.90630073
30KIT1.77176571
31WEE11.76587226
32TYK21.69823741
33EIF2AK11.63437776
34JAK31.59860319
35MAPK151.59695236
36BUB11.56938348
37RPS6KB21.55983672
38BRSK21.48559307
39MAP3K41.47347494
40PHKG11.43368457
41PHKG21.43368457
42MKNK21.39574865
43IKBKE1.38796423
44MAP3K71.37349036
45MARK11.34819879
46MAPK131.33142238
47MAP3K61.32339323
48RPS6KA41.30551269
49LRRK21.25690391
50CLK11.22657870
51MAPK111.19104523
52BTK1.17655578
53PIM11.17090361
54NEK91.16596472
55STK31.13679604
56MATK1.13241878
57PKN21.12884565
58PINK11.10445366
59ZAP701.09731193
60STK241.09713301
61TRIM281.09376140
62FER1.09251209
63TESK11.07883245
64VRK11.05634712
65VRK21.05104577
66IRAK41.04957734
67CDK191.04386930
68MAPKAPK31.04167619
69PBK1.02761872
70IKBKB1.01368061
71BLK1.01188750
72ABL20.99516597
73PLK20.98868701
74PNCK0.98550253
75EPHA30.96958848
76NEK20.95753303
77SCYL20.94785270
78DYRK30.94280181
79STK100.91153397
80PAK30.91068489
81PRKCE0.89572750
82FGFR20.88028516
83CCNB10.87954023
84DAPK20.86848681
85DYRK1B0.86668367
86STK110.86566158
87ADRBK10.86035439
88MST40.83552951
89TRIB30.83100520
90IRAK30.82959739
91PRKAA20.82692981
92FGFR40.82129858
93LYN0.81248488
94MAP2K30.79220033
95CDK80.78480657
96ILK0.77876202
97AURKB0.77230925
98MAP2K20.76113254
99DAPK30.75770909
100PIK3CG0.75763621
101MUSK0.75480100
102SYK0.75266374
103MYLK0.74981625
104EIF2AK30.74799093
105MAP3K30.74591018
106CSK0.73108500
107CASK0.72137521
108PRKAA10.71454904
109MAP2K70.70035334
110CSNK1G10.69913714
111MAP3K140.69194356
112NME10.69085852
113DYRK20.68645438
114MAP3K120.68483163
115IRAK10.67259666
116PLK10.65142431
117PRKG20.64376694
118PRKCG0.64033360
119GRK60.63815309
120CDK70.63546772
121AURKA0.63530989
122TNK20.63512691
123MAP2K60.62506857
124BRAF0.62085716
125JAK20.61778979
126PLK30.61664069
127CDK40.61023343
128TGFBR10.60700343
129TXK0.60690134
130TAOK10.60131369
131RPS6KA50.59689979
132ERBB30.59627406
133MAP3K80.58368171
134CSNK2A10.58084815
135STK40.57755569
136CSNK1G20.56929336
137PLK40.56860225
138MAPK40.56580937
139TIE10.54199651
140CAMKK20.53604074
141PKN10.53516786
142MKNK10.52464138
143TGFBR20.52396156
144HIPK20.51683129
145PAK40.50216851
146TRPM70.49817121
147PRKACA0.49226975
148MST1R0.49208553
149STK38L0.48732301
150LATS10.47886522
151RAF10.47512478
152NLK0.47153616
153PTK2B0.46458843
154CAMK10.46363006
155LCK0.46307359
156MOS0.46307050
157ARAF0.45974732
158MAP3K100.45485985
159CSNK1G30.44933391
160CAMK2A0.44817770
161CDK60.44204331
162CHEK20.43666954
163CDC70.42831900
164TTK0.41894947
165PRKCQ0.41530884
166TAF10.41053998
167SGK10.40831099
168PIK3CA0.38680200
169PRKCA0.38418094
170CDK30.37439819
171ATM0.35289722
172CSNK1A10.34298347
173CSNK1A1L0.34039722

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38004332
2DNA replication_Homo sapiens_hsa030302.62556821
3Oxidative phosphorylation_Homo sapiens_hsa001902.55975776
4Parkinsons disease_Homo sapiens_hsa050122.47186762
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25415168
6Phototransduction_Homo sapiens_hsa047442.24755266
7Folate biosynthesis_Homo sapiens_hsa007902.23597746
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11191745
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10639905
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05689873
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01168107
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00096292
13Sulfur relay system_Homo sapiens_hsa041221.97968269
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.94683948
15Mismatch repair_Homo sapiens_hsa034301.93334180
16Nitrogen metabolism_Homo sapiens_hsa009101.89646983
17Homologous recombination_Homo sapiens_hsa034401.84320545
18Regulation of autophagy_Homo sapiens_hsa041401.84206518
19Protein export_Homo sapiens_hsa030601.84021872
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78469329
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76521816
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.74993198
23Proteasome_Homo sapiens_hsa030501.74427395
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.73147059
25Basal transcription factors_Homo sapiens_hsa030221.69437111
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65917867
27Huntingtons disease_Homo sapiens_hsa050161.57779701
28Fatty acid degradation_Homo sapiens_hsa000711.53933818
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53405330
30Base excision repair_Homo sapiens_hsa034101.52870023
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52577548
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.52340232
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51497620
34Pentose phosphate pathway_Homo sapiens_hsa000301.50810093
35Sulfur metabolism_Homo sapiens_hsa009201.50668733
36Alzheimers disease_Homo sapiens_hsa050101.50043803
37Pyrimidine metabolism_Homo sapiens_hsa002401.48725826
38Peroxisome_Homo sapiens_hsa041461.46803643
39Selenocompound metabolism_Homo sapiens_hsa004501.45283508
40Nicotine addiction_Homo sapiens_hsa050331.38964656
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38056904
42Circadian rhythm_Homo sapiens_hsa047101.34223790
43Ether lipid metabolism_Homo sapiens_hsa005651.32256875
44Chemical carcinogenesis_Homo sapiens_hsa052041.30723808
45ABC transporters_Homo sapiens_hsa020101.30422500
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.28715596
47Tryptophan metabolism_Homo sapiens_hsa003801.28410158
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27189325
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25892784
50Non-homologous end-joining_Homo sapiens_hsa034501.22580790
51Glutathione metabolism_Homo sapiens_hsa004801.21907398
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21870677
53RNA polymerase_Homo sapiens_hsa030201.21455642
54Olfactory transduction_Homo sapiens_hsa047401.20491821
55Nucleotide excision repair_Homo sapiens_hsa034201.19299044
56Dorso-ventral axis formation_Homo sapiens_hsa043201.17938959
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14628691
58Taste transduction_Homo sapiens_hsa047421.10331445
59Carbon metabolism_Homo sapiens_hsa012001.08680514
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08247214
61Propanoate metabolism_Homo sapiens_hsa006401.07476207
62One carbon pool by folate_Homo sapiens_hsa006701.07402609
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.07360893
64Caffeine metabolism_Homo sapiens_hsa002321.05388163
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00590695
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99603974
67Mineral absorption_Homo sapiens_hsa049780.96936087
68Histidine metabolism_Homo sapiens_hsa003400.94803853
69Pyruvate metabolism_Homo sapiens_hsa006200.93858507
70Primary immunodeficiency_Homo sapiens_hsa053400.93812222
71Biosynthesis of amino acids_Homo sapiens_hsa012300.92213663
72beta-Alanine metabolism_Homo sapiens_hsa004100.91035432
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90828094
74Complement and coagulation cascades_Homo sapiens_hsa046100.90366866
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89578529
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87798901
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84592245
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84231257
79Glycerolipid metabolism_Homo sapiens_hsa005610.83396349
80Arginine biosynthesis_Homo sapiens_hsa002200.83045441
81Starch and sucrose metabolism_Homo sapiens_hsa005000.82960043
82Staphylococcus aureus infection_Homo sapiens_hsa051500.82256619
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80406230
84Linoleic acid metabolism_Homo sapiens_hsa005910.79036677
85Fat digestion and absorption_Homo sapiens_hsa049750.77864872
86PPAR signaling pathway_Homo sapiens_hsa033200.76603897
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74606023
88Retinol metabolism_Homo sapiens_hsa008300.74601377
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.74565998
90Metabolic pathways_Homo sapiens_hsa011000.73839155
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72697877
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71010041
93Fatty acid elongation_Homo sapiens_hsa000620.70849988
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70605041
95Galactose metabolism_Homo sapiens_hsa000520.69056594
96Fatty acid metabolism_Homo sapiens_hsa012120.68587204
97Antigen processing and presentation_Homo sapiens_hsa046120.65206730
98Arginine and proline metabolism_Homo sapiens_hsa003300.63447483
99p53 signaling pathway_Homo sapiens_hsa041150.62325896
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62270695
101Spliceosome_Homo sapiens_hsa030400.62164316
102Butanoate metabolism_Homo sapiens_hsa006500.61793445
103Thyroid cancer_Homo sapiens_hsa052160.60957057
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60174607
105Calcium signaling pathway_Homo sapiens_hsa040200.59793511
106Herpes simplex infection_Homo sapiens_hsa051680.57980963
107Tyrosine metabolism_Homo sapiens_hsa003500.57760440
108Legionellosis_Homo sapiens_hsa051340.57088749
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.56317973
110Arachidonic acid metabolism_Homo sapiens_hsa005900.56006245
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55707884
112Serotonergic synapse_Homo sapiens_hsa047260.54695186
113Systemic lupus erythematosus_Homo sapiens_hsa053220.54385547
114GABAergic synapse_Homo sapiens_hsa047270.53701644
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.53534184
116Morphine addiction_Homo sapiens_hsa050320.52628124
117Insulin secretion_Homo sapiens_hsa049110.52091700
118Asthma_Homo sapiens_hsa053100.51159382
119Fructose and mannose metabolism_Homo sapiens_hsa000510.51003631
120Ovarian steroidogenesis_Homo sapiens_hsa049130.49109528
121Fanconi anemia pathway_Homo sapiens_hsa034600.47423089
122Phenylalanine metabolism_Homo sapiens_hsa003600.46952522
123Cardiac muscle contraction_Homo sapiens_hsa042600.46403516
124Leishmaniasis_Homo sapiens_hsa051400.45305243
125Purine metabolism_Homo sapiens_hsa002300.44546639
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43948859
127Cell cycle_Homo sapiens_hsa041100.43833307
128RNA degradation_Homo sapiens_hsa030180.42049781
129RNA transport_Homo sapiens_hsa030130.40585428
130Allograft rejection_Homo sapiens_hsa053300.39907279
131Glutamatergic synapse_Homo sapiens_hsa047240.38783838
132Collecting duct acid secretion_Homo sapiens_hsa049660.35021854
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34565947
134Measles_Homo sapiens_hsa051620.34182516
135Other glycan degradation_Homo sapiens_hsa005110.33771804
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33329576
137Type I diabetes mellitus_Homo sapiens_hsa049400.31724004
138Salivary secretion_Homo sapiens_hsa049700.31418306
139N-Glycan biosynthesis_Homo sapiens_hsa005100.30692824
140Lysine degradation_Homo sapiens_hsa003100.30544210

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