PCBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.77210286
2DNA unwinding involved in DNA replication (GO:0006268)4.70053090
3negative regulation of erythrocyte differentiation (GO:0045647)4.61964302
4viral transcription (GO:0019083)4.38841070
5negative regulation of cell killing (GO:0031342)4.34811020
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34811020
7DNA deamination (GO:0045006)4.33351019
8positive regulation of gamma-delta T cell activation (GO:0046645)4.32794361
9translational termination (GO:0006415)4.31423118
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.20158155
11DNA strand elongation involved in DNA replication (GO:0006271)4.19660192
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18585191
13folic acid-containing compound biosynthetic process (GO:0009396)4.09527810
14antigen processing and presentation of endogenous antigen (GO:0019883)4.07538512
15translational initiation (GO:0006413)4.07288429
16modulation by symbiont of host immune response (GO:0052553)4.04369702
17positive regulation by symbiont of host defense response (GO:0052509)4.04369702
18modulation by symbiont of host defense response (GO:0052031)4.04369702
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04369702
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04369702
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.04369702
22protein localization to kinetochore (GO:0034501)4.00841374
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99425590
24translational elongation (GO:0006414)3.96635142
25DNA strand elongation (GO:0022616)3.93327915
26negative regulation of RNA splicing (GO:0033119)3.81758074
27DNA replication initiation (GO:0006270)3.80957393
28maturation of SSU-rRNA (GO:0030490)3.80545970
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79842500
30detection of bacterium (GO:0016045)3.63148390
31telomere maintenance via semi-conservative replication (GO:0032201)3.60791540
32negative regulation of mRNA processing (GO:0050686)3.60537653
33nucleobase biosynthetic process (GO:0046112)3.57458617
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56947164
35ribosomal small subunit assembly (GO:0000028)3.55434179
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53797849
37heterochromatin organization (GO:0070828)3.51912432
38ribosomal small subunit biogenesis (GO:0042274)3.51183729
39response to peptidoglycan (GO:0032494)3.49214433
40detection of other organism (GO:0098543)3.47087228
41ribosome assembly (GO:0042255)3.45338360
42protein targeting to ER (GO:0045047)3.44774068
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42882766
44mitotic nuclear envelope disassembly (GO:0007077)3.42223289
45viral life cycle (GO:0019058)3.41633993
46cotranslational protein targeting to membrane (GO:0006613)3.40958193
47DNA replication checkpoint (GO:0000076)3.38138072
48protein localization to chromosome, centromeric region (GO:0071459)3.34692294
49thymic T cell selection (GO:0045061)3.34194782
50ribosome biogenesis (GO:0042254)3.32921485
51cellular protein complex disassembly (GO:0043624)3.30132099
52ribonucleoprotein complex biogenesis (GO:0022613)3.29271147
53ribosomal large subunit biogenesis (GO:0042273)3.29231319
54negative regulation of mRNA metabolic process (GO:1903312)3.27994029
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26803077
56regulation of translational fidelity (GO:0006450)3.22757193
57modulation by virus of host process (GO:0019054)3.22506430
58positive thymic T cell selection (GO:0045059)3.22369805
59peptidyl-arginine omega-N-methylation (GO:0035247)3.21569994
60protein localization to endoplasmic reticulum (GO:0070972)3.20333498
61membrane disassembly (GO:0030397)3.19385255
62nuclear envelope disassembly (GO:0051081)3.19385255
63regulation of gamma-delta T cell activation (GO:0046643)3.18745246
64folic acid metabolic process (GO:0046655)3.17519977
65protein complex disassembly (GO:0043241)3.17448178
663-UTR-mediated mRNA stabilization (GO:0070935)3.16290031
67dosage compensation (GO:0007549)3.13587161
68purine nucleobase biosynthetic process (GO:0009113)3.09645702
69negative regulation of phagocytosis (GO:0050765)3.08948973
70regulation of translational termination (GO:0006449)3.07652045
71modulation by symbiont of host cellular process (GO:0044068)3.03619127
72regulation of early endosome to late endosome transport (GO:2000641)3.00356409
73* mRNA splicing, via spliceosome (GO:0000398)2.97547955
74* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.97547955
75telomere maintenance via recombination (GO:0000722)2.97488111
76leukocyte aggregation (GO:0070486)2.97245136
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96451139
78* RNA splicing, via transesterification reactions (GO:0000375)2.96282229
79IMP biosynthetic process (GO:0006188)2.95426854
80regulation of gamma-delta T cell differentiation (GO:0045586)2.95232721
81mitotic metaphase plate congression (GO:0007080)2.94943198
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94223159
83macromolecular complex disassembly (GO:0032984)2.93608127
84immunoglobulin mediated immune response (GO:0016064)2.93187642
85spliceosomal snRNP assembly (GO:0000387)2.93035463
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.92989756
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92749842
88regulation of B cell receptor signaling pathway (GO:0050855)2.92683385
89pinocytosis (GO:0006907)2.90898127
90DNA replication-dependent nucleosome organization (GO:0034723)2.90490587
91DNA replication-dependent nucleosome assembly (GO:0006335)2.90490587
92regulation of spindle organization (GO:0090224)2.89513040
93rRNA processing (GO:0006364)2.88487386
94regulation of chromatin binding (GO:0035561)2.87644992
95telomere maintenance via telomere lengthening (GO:0010833)2.86265103
96NIK/NF-kappaB signaling (GO:0038061)2.85641305
97maternal placenta development (GO:0001893)2.85455371
98regulation of posttranscriptional gene silencing (GO:0060147)2.84663016
99regulation of gene silencing by miRNA (GO:0060964)2.84663016
100regulation of gene silencing by RNA (GO:0060966)2.84663016
101neutrophil activation involved in immune response (GO:0002283)2.84379143
102T cell apoptotic process (GO:0070231)2.83840015
103histone arginine methylation (GO:0034969)2.83051749
104positive regulation of Cdc42 GTPase activity (GO:0043089)2.82682149
105pre-miRNA processing (GO:0031054)2.82269174
106termination of RNA polymerase II transcription (GO:0006369)2.81557242
107RNA catabolic process (GO:0006401)2.80884412
108negative thymic T cell selection (GO:0045060)2.80730624
109T cell selection (GO:0045058)2.80369317
110apoptotic process involved in morphogenesis (GO:0060561)2.79952209
111translation (GO:0006412)2.79917422
112rRNA metabolic process (GO:0016072)2.78572779
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78031120
114mitotic recombination (GO:0006312)2.77882195
115nuclear envelope organization (GO:0006998)2.77349570
116mRNA catabolic process (GO:0006402)2.76800941
117mannose metabolic process (GO:0006013)2.75275551
118response to muramyl dipeptide (GO:0032495)2.74487981
119protein localization to chromosome (GO:0034502)2.72950699
120peptidyl-arginine methylation (GO:0018216)2.72752979
121peptidyl-arginine N-methylation (GO:0035246)2.72752979
122cellular response to interleukin-4 (GO:0071353)2.69125000
123macrophage activation involved in immune response (GO:0002281)2.68957193
124pteridine-containing compound biosynthetic process (GO:0042559)2.68639080
125mitotic chromosome condensation (GO:0007076)2.68472458
126DNA duplex unwinding (GO:0032508)2.68147257
127intracellular estrogen receptor signaling pathway (GO:0030520)2.67942570
128mitotic G1 DNA damage checkpoint (GO:0031571)2.66789142
129B cell receptor signaling pathway (GO:0050853)2.66186024
130DNA geometric change (GO:0032392)2.64478204
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64384938
132mitochondrial DNA metabolic process (GO:0032042)2.64319708
133mitotic sister chromatid segregation (GO:0000070)2.63986296
134negative T cell selection (GO:0043383)2.62186296
135respiratory burst (GO:0045730)2.62016530
136detection of external biotic stimulus (GO:0098581)2.61332989
137negative regulation of interleukin-12 production (GO:0032695)2.61323685
138pentose-phosphate shunt (GO:0006098)2.60926489
139positive regulation of chromosome segregation (GO:0051984)2.60622207
140IMP metabolic process (GO:0046040)2.60505634
141negative regulation of necroptotic process (GO:0060546)2.59948698
142RNA stabilization (GO:0043489)2.59606826
143mRNA stabilization (GO:0048255)2.59606826
144trophectodermal cell differentiation (GO:0001829)2.59347103
145cellular hyperosmotic response (GO:0071474)2.59297014
146regulation of mast cell degranulation (GO:0043304)2.59029700
147negative regulation of translational initiation (GO:0045947)2.57870829
148response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57249253
149response to host immune response (GO:0052572)2.57249253
150regulation of protein heterodimerization activity (GO:0043497)2.57235331
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.56599123
152embryonic process involved in female pregnancy (GO:0060136)2.56375362
153antigen processing and presentation via MHC class Ib (GO:0002475)2.55619086
154regulation of mitotic spindle organization (GO:0060236)2.55213781
155negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55159545
156protein complex localization (GO:0031503)2.54515714
157positive regulation of B cell differentiation (GO:0045579)2.54465090
158base-excision repair (GO:0006284)2.54348354
159regulation of translational initiation (GO:0006446)2.54325508
160response to host (GO:0075136)2.54258744
161response to host defenses (GO:0052200)2.54258744
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54258744
163regulation of superoxide anion generation (GO:0032928)2.54217410
164tolerance induction (GO:0002507)2.54153882
165histone H3-K36 demethylation (GO:0070544)2.51750554
166response to interleukin-4 (GO:0070670)2.50713346
167regulation of leukocyte degranulation (GO:0043300)2.50615101
168regulation of B cell differentiation (GO:0045577)2.45853110
169positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.45724608
170regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44625219
171negative regulation of lymphocyte mediated immunity (GO:0002707)2.44145921
172myeloid dendritic cell differentiation (GO:0043011)2.43247679
173NADPH regeneration (GO:0006740)2.42833999
174B cell mediated immunity (GO:0019724)2.41621583
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39798205
176response to interleukin-15 (GO:0070672)2.38270000
177Peyers patch development (GO:0048541)2.38139662
178mucosal-associated lymphoid tissue development (GO:0048537)2.38139662
179lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36727334
180regulation of defense response to virus by virus (GO:0050690)2.36426110
181negative regulation of leukocyte mediated immunity (GO:0002704)2.35343779
182regulation of histone H3-K27 methylation (GO:0061085)2.35168732
183detection of biotic stimulus (GO:0009595)2.34920688
184proline biosynthetic process (GO:0006561)2.33809201
185regulation of interferon-beta biosynthetic process (GO:0045357)2.33509223
186regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32778509
187regulation of interleukin-2 biosynthetic process (GO:0045076)2.32648307
188signal complex assembly (GO:0007172)2.32531744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.92110360
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88569052
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.73799591
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.23916555
5MYC_22102868_ChIP-Seq_BL_Human2.75057568
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73798288
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45032029
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37295380
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34236049
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29026164
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.25792153
12* XRN2_22483619_ChIP-Seq_HELA_Human2.24903154
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.14491250
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.08833166
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02080312
16* VDR_24763502_ChIP-Seq_THP-1_Human2.00505697
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99411052
18VDR_21846776_ChIP-Seq_THP-1_Human1.98134022
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93649315
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89789602
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.87311622
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86798278
23* GABP_17652178_ChIP-ChIP_JURKAT_Human1.74380646
24AR_21909140_ChIP-Seq_LNCAP_Human1.70746394
25* GABP_19822575_ChIP-Seq_HepG2_Human1.66606513
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66220388
27ZNF263_19887448_ChIP-Seq_K562_Human1.65026369
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64296746
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64197800
30* DCP1A_22483619_ChIP-Seq_HELA_Human1.63268982
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61490421
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61083429
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59932671
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59700351
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.59559290
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58331928
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57385096
38CIITA_25753668_ChIP-Seq_RAJI_Human1.56865926
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55901742
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54068454
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52893261
42* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52219194
43TTF2_22483619_ChIP-Seq_HELA_Human1.52054646
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51718517
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51144808
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49991558
47VDR_23849224_ChIP-Seq_CD4+_Human1.49891638
48* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49766939
49* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48733006
50KDM5A_27292631_Chip-Seq_BREAST_Human1.48512848
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45167099
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44703266
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44682134
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.43662702
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43142713
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41884771
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.41215985
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40440350
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40119656
60NCOR1_26117541_ChIP-Seq_K562_Human1.39912302
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39466956
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39443699
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38678489
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37263566
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36710027
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36638602
67* FOXP3_21729870_ChIP-Seq_TREG_Human1.36507451
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36466354
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36068899
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35504582
71SPI1_23547873_ChIP-Seq_NB4_Human1.33857432
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.32265792
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32162795
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31804323
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.31119594
76P68_20966046_ChIP-Seq_HELA_Human1.28880486
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.27542776
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25051701
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24439099
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.24326791
81KDM2B_26808549_Chip-Seq_K562_Human1.23373757
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23157977
83* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21400828
84TFEB_21752829_ChIP-Seq_HELA_Human1.21217380
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20913423
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20753126
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.19993164
88* ATF3_27146783_Chip-Seq_COLON_Human1.19283509
89* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18576757
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17983649
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17706597
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16842500
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16688361
94* YY1_21170310_ChIP-Seq_MESCs_Mouse1.16673604
95* TCF7_22412390_ChIP-Seq_EML_Mouse1.15657832
96MYB_26560356_Chip-Seq_TH1_Human1.15419043
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14610372
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14418606
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.14340797
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12748218
101SCL_19346495_ChIP-Seq_HPC-7_Human1.11759182
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11701845
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10721620
104* MYB_26560356_Chip-Seq_TH2_Human1.09752030
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09559259
106KDM2B_26808549_Chip-Seq_DND41_Human1.08990344
107LXR_22292898_ChIP-Seq_THP-1_Human1.08631045
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08117261
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08078945
110BCOR_27268052_Chip-Seq_Bcells_Human1.07580183
111* MAF_26560356_Chip-Seq_TH1_Human1.07503697
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.07410543
113* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06834866
114CLOCK_20551151_ChIP-Seq_293T_Human1.06762335
115UTX_26944678_Chip-Seq_JUKART_Human1.06453656
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06449068
117SPI1_23127762_ChIP-Seq_K562_Human1.06002647
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05657025
119OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05583143
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04995069
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04708538
122* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04010796
123* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03571614
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02804308
125RACK7_27058665_Chip-Seq_MCF-7_Human1.02250189
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02003045
127NANOG_21062744_ChIP-ChIP_HESCs_Human1.01729392
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01665822
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01162568
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00879142
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00769777
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00769777
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00769777
134* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00738985
135SMC4_20622854_ChIP-Seq_HELA_Human1.00140218
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98277555
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95959562
138* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95767514
139MAF_26560356_Chip-Seq_TH2_Human0.95569193
140CHD1_26751641_Chip-Seq_LNCaP_Human0.95353749
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95278538
142FOXP1_21924763_ChIP-Seq_HESCs_Human0.93572698
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93462899
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93067458
145* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92506672
146GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91796654
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90890599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.12962548
2MP0004957_abnormal_blastocyst_morpholog3.86914828
3MP0003111_abnormal_nucleus_morphology3.37064854
4MP0005451_abnormal_body_composition3.26773062
5MP0003077_abnormal_cell_cycle2.92202889
6MP0010094_abnormal_chromosome_stability2.75288901
7MP0010352_gastrointestinal_tract_polyps2.74042883
8MP0010030_abnormal_orbit_morphology2.60802449
9MP0003705_abnormal_hypodermis_morpholog2.52925921
10MP0008057_abnormal_DNA_replication2.45986229
11MP0008260_abnormal_autophagy2.39969802
12MP0001835_abnormal_antigen_presentation2.39921869
13MP0001730_embryonic_growth_arrest2.35615981
14MP0005058_abnormal_lysosome_morphology2.24552817
15MP0003123_paternal_imprinting2.22767089
16MP0005076_abnormal_cell_differentiation2.13189130
17MP0005025_abnormal_response_to2.08701593
18MP0000350_abnormal_cell_proliferation2.06826534
19MP0005000_abnormal_immune_tolerance2.06788902
20MP0001790_abnormal_immune_system2.06762968
21MP0005387_immune_system_phenotype2.06762968
22MP0000490_abnormal_crypts_of2.02483712
23MP0008932_abnormal_embryonic_tissue2.02020043
24MP0001800_abnormal_humoral_immune2.00039716
25MP0005671_abnormal_response_to1.98892035
26MP0002419_abnormal_innate_immunity1.97704582
27MP0009278_abnormal_bone_marrow1.94730031
28MP0008007_abnormal_cellular_replicative1.91982437
29MP0002420_abnormal_adaptive_immunity1.87340663
30MP0002396_abnormal_hematopoietic_system1.85016040
31MP0001819_abnormal_immune_cell1.84529771
32MP0001697_abnormal_embryo_size1.83111986
33MP0002653_abnormal_ependyma_morphology1.81162971
34MP0005464_abnormal_platelet_physiology1.79054445
35MP0005380_embryogenesis_phenotype1.77442740
36MP0001672_abnormal_embryogenesis/_devel1.77442740
37MP0002723_abnormal_immune_serum1.74098738
38MP0002452_abnormal_antigen_presenting1.72078809
39MP0002085_abnormal_embryonic_tissue1.68935066
40MP0003984_embryonic_growth_retardation1.68675682
41MP0002080_prenatal_lethality1.66986604
42MP0002088_abnormal_embryonic_growth/wei1.66477682
43MP0009785_altered_susceptibility_to1.64328368
44MP0003567_abnormal_fetal_cardiomyocyte1.64147641
45MP0004197_abnormal_fetal_growth/weight/1.62012139
46MP0000678_abnormal_parathyroid_gland1.61921332
47MP0002084_abnormal_developmental_patter1.61175483
48MP0002086_abnormal_extraembryonic_tissu1.60725542
49MP0009840_abnormal_foam_cell1.58186319
50MP0000537_abnormal_urethra_morphology1.57260787
51MP0000716_abnormal_immune_system1.57257841
52MP0009333_abnormal_splenocyte_physiolog1.57016943
53MP0005397_hematopoietic_system_phenotyp1.51879329
54MP0001545_abnormal_hematopoietic_system1.51879329
55MP0004947_skin_inflammation1.50296670
56MP0003172_abnormal_lysosome_physiology1.49001028
57MP0008058_abnormal_DNA_repair1.47543822
58MP0001849_ear_inflammation1.44038687
59MP0004858_abnormal_nervous_system1.40923528
60MP0010155_abnormal_intestine_physiology1.38974560
61MP0002148_abnormal_hypersensitivity_rea1.37456035
62MP0003724_increased_susceptibility_to1.37385744
63MP0003119_abnormal_digestive_system1.36724375
64MP0009053_abnormal_anal_canal1.36634127
65MP0004381_abnormal_hair_follicle1.30826894
66MP0000313_abnormal_cell_death1.29186085
67MP0002019_abnormal_tumor_incidence1.28299321
68MP0010307_abnormal_tumor_latency1.27977171
69MP0003566_abnormal_cell_adhesion1.27730385
70MP0002877_abnormal_melanocyte_morpholog1.22158351
71MP0005666_abnormal_adipose_tissue1.21926208
72MP0001533_abnormal_skeleton_physiology1.18411968
73MP0004808_abnormal_hematopoietic_stem1.18338893
74MP0001873_stomach_inflammation1.14487183
75MP0003828_pulmonary_edema1.11908538
76MP0003303_peritoneal_inflammation1.09676557
77MP0001845_abnormal_inflammatory_respons1.09466718
78MP0005023_abnormal_wound_healing1.09428268
79MP0002166_altered_tumor_susceptibility1.09233476
80MP0002998_abnormal_bone_remodeling1.08565532
81MP0009672_abnormal_birth_weight1.07406699
82MP0001853_heart_inflammation1.06360243
83MP0004510_myositis1.06104195
84MP0006054_spinal_hemorrhage1.05875225
85MP0004264_abnormal_extraembryonic_tissu1.05681675
86MP0000703_abnormal_thymus_morphology1.05362751
87MP0003806_abnormal_nucleotide_metabolis1.05171750
88MP0000477_abnormal_intestine_morphology1.03917676
89MP0006082_CNS_inflammation1.01802649
90MP0003786_premature_aging1.01773640
91MP0000733_abnormal_muscle_development1.01369690
92MP0003221_abnormal_cardiomyocyte_apopto1.00647305
93MP0003656_abnormal_erythrocyte_physiolo1.00134926
94MP0004185_abnormal_adipocyte_glucose0.99833076
95MP0000858_altered_metastatic_potential0.99678331
96MP0000685_abnormal_immune_system0.97794576
97MP0001293_anophthalmia0.97493532
98MP0005501_abnormal_skin_physiology0.93865096
99MP0008469_abnormal_protein_level0.93711451
100MP0003283_abnormal_digestive_organ0.93632230
101MP0002722_abnormal_immune_system0.93314371
102MP0001348_abnormal_lacrimal_gland0.93199113
103MP0003183_abnormal_peptide_metabolism0.92417955
104MP0003763_abnormal_thymus_physiology0.91803509
105MP0001915_intracranial_hemorrhage0.90912615
106MP0004133_heterotaxia0.90598007
107MP0002398_abnormal_bone_marrow0.90490138
108MP0002111_abnormal_tail_morphology0.88135850
109MP0004233_abnormal_muscle_weight0.88035016
110MP0000689_abnormal_spleen_morphology0.85246081
111MP0003191_abnormal_cellular_cholesterol0.84218799
112MP0002089_abnormal_postnatal_growth/wei0.84005511
113MP0003091_abnormal_cell_migration0.83066808
114MP0005220_abnormal_exocrine_pancreas0.82882416
115MP0010234_abnormal_vibrissa_follicle0.82776998
116MP0005310_abnormal_salivary_gland0.82501283
117MP0002092_abnormal_eye_morphology0.82482712
118MP0000358_abnormal_cell_content/0.81945260
119MP0000428_abnormal_craniofacial_morphol0.81333272
120MP0010630_abnormal_cardiac_muscle0.80923647
121MP0000750_abnormal_muscle_regeneration0.78791678
122MP0003453_abnormal_keratinocyte_physiol0.78111444
123MP0005375_adipose_tissue_phenotype0.77980030
124MP0000759_abnormal_skeletal_muscle0.76707254
125MP0002249_abnormal_larynx_morphology0.76389795
126MP0003115_abnormal_respiratory_system0.75385231
127MP0008770_decreased_survivor_rate0.75073282
128MP0001851_eye_inflammation0.73588026
129MP0000598_abnormal_liver_morphology0.73392395
130MP0002429_abnormal_blood_cell0.72522057
131MP0008961_abnormal_basal_metabolism0.71160410
132MP0003718_maternal_effect0.70621086
133MP0002932_abnormal_joint_morphology0.70254667
134MP0003300_gastrointestinal_ulcer0.69280936
135MP0000465_gastrointestinal_hemorrhage0.68889430
136MP0005621_abnormal_cell_physiology0.68517195
137MP0002925_abnormal_cardiovascular_devel0.67447750
138MP0009703_decreased_birth_body0.66470042
139MP0005384_cellular_phenotype0.65830423
140MP0003890_abnormal_embryonic-extraembry0.65136812
141MP0002405_respiratory_system_inflammati0.64713449
142MP0002697_abnormal_eye_size0.64362436
143MP0002796_impaired_skin_barrier0.63341214
144MP0002132_abnormal_respiratory_system0.62258444
145MP0002282_abnormal_trachea_morphology0.61955351
146MP0003436_decreased_susceptibility_to0.61349755
147MP0009931_abnormal_skin_appearance0.60823706
148MP0003866_abnormal_defecation0.59772514

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.17230199
2Eczematoid dermatitis (HP:0000976)4.15690221
3Abnormal number of erythroid precursors (HP:0012131)3.88076803
4Multiple enchondromatosis (HP:0005701)3.69435578
5Selective tooth agenesis (HP:0001592)3.56547180
6Trismus (HP:0000211)3.43137401
7Abnormality of macrophages (HP:0004311)3.41629786
8Reticulocytopenia (HP:0001896)3.30320689
9Breast hypoplasia (HP:0003187)3.12540052
10Recurrent abscess formation (HP:0002722)3.06294629
11Abnormal gallbladder physiology (HP:0012438)3.05877854
12Cholecystitis (HP:0001082)3.05877854
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.97968015
14Recurrent bacterial skin infections (HP:0005406)2.97510893
15Increased IgE level (HP:0003212)2.97064509
16Ependymoma (HP:0002888)2.96493602
17Cellulitis (HP:0100658)2.94855004
18Degeneration of anterior horn cells (HP:0002398)2.92710264
19Abnormality of the anterior horn cell (HP:0006802)2.92710264
20Myopathic facies (HP:0002058)2.92351798
21Chronic obstructive pulmonary disease (HP:0006510)2.91913663
22Obstructive lung disease (HP:0006536)2.91913663
23Gastrointestinal stroma tumor (HP:0100723)2.90981232
24Meningitis (HP:0001287)2.88998104
25Oral leukoplakia (HP:0002745)2.88719116
26Birth length less than 3rd percentile (HP:0003561)2.83067836
27Patellar aplasia (HP:0006443)2.65420821
28Protrusio acetabuli (HP:0003179)2.64437707
29Urticaria (HP:0001025)2.61756537
30Gastrointestinal infarctions (HP:0005244)2.59977065
31Microretrognathia (HP:0000308)2.58853639
32Carpal bone hypoplasia (HP:0001498)2.57167422
33Macrocytic anemia (HP:0001972)2.56519876
34Aplasia/Hypoplasia of the patella (HP:0006498)2.56361659
35Overlapping toe (HP:0001845)2.55147101
36Myositis (HP:0100614)2.51422557
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50135519
38Rough bone trabeculation (HP:0100670)2.49713293
39Mediastinal lymphadenopathy (HP:0100721)2.46405965
40Long palpebral fissure (HP:0000637)2.45671342
41Increased IgM level (HP:0003496)2.44881080
42Colon cancer (HP:0003003)2.42586112
43Hyperacusis (HP:0010780)2.41655272
44Agammaglobulinemia (HP:0004432)2.39833018
45Proximal placement of thumb (HP:0009623)2.38950433
46Recurrent viral infections (HP:0004429)2.37924545
47Vasculitis (HP:0002633)2.37867103
48Basal cell carcinoma (HP:0002671)2.37610107
49Abnormality of skeletal muscle fiber size (HP:0012084)2.37393898
50Gastrointestinal inflammation (HP:0004386)2.36196075
51Recurrent fungal infections (HP:0002841)2.35242769
52Reticulocytosis (HP:0001923)2.33746847
53Atresia of the external auditory canal (HP:0000413)2.33622271
54Pallor (HP:0000980)2.32823624
55Hypertensive crisis (HP:0100735)2.32354252
56Exercise-induced myalgia (HP:0003738)2.32021348
57Recurrent gram-negative bacterial infections (HP:0005420)2.29267815
58Increased connective tissue (HP:0009025)2.27113425
59Progressive muscle weakness (HP:0003323)2.26878412
60Neoplasm of the pancreas (HP:0002894)2.25923712
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.25368336
62Abnormal number of incisors (HP:0011064)2.24008185
63Deviation of the thumb (HP:0009603)2.22881906
64Spontaneous hematomas (HP:0007420)2.22545764
65Increased variability in muscle fiber diameter (HP:0003557)2.22228498
66Genu recurvatum (HP:0002816)2.22074331
67Hypochromic anemia (HP:0001931)2.20936728
68Orchitis (HP:0100796)2.19843938
69Purpura (HP:0000979)2.19126261
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.18792622
71Adenoma sebaceum (HP:0009720)2.18270562
72Angiofibromas (HP:0010615)2.18270562
73Elevated erythrocyte sedimentation rate (HP:0003565)2.18141857
74Renal duplication (HP:0000075)2.15896132
75Ankle contracture (HP:0006466)2.14671452
76Lymphopenia (HP:0001888)2.13868948
77Absent thumb (HP:0009777)2.13519333
78Petechiae (HP:0000967)2.11489878
79Segmental peripheral demyelination/remyelination (HP:0003481)2.10870682
80Polygenic inheritance (HP:0010982)2.08998203
81Increased nuchal translucency (HP:0010880)2.08940097
82Abnormality of reticulocytes (HP:0004312)2.08901418
83Prolonged bleeding time (HP:0003010)2.08842633
84Slender long bone (HP:0003100)2.07502397
85Recurrent skin infections (HP:0001581)2.07144033
86Deep palmar crease (HP:0006191)2.06661955
87Distal lower limb muscle weakness (HP:0009053)2.06495410
88Aplastic anemia (HP:0001915)2.05286568
89Increased serum ferritin (HP:0003281)2.05227007
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04881844
91Encephalitis (HP:0002383)2.03620100
92Inflammation of the large intestine (HP:0002037)2.03543548
93Abnormality of the umbilical cord (HP:0010881)2.02830420
94Thoracic kyphosis (HP:0002942)2.02761051
95Osteomyelitis (HP:0002754)2.02499940
96Colitis (HP:0002583)2.01717295
97Facial hemangioma (HP:0000329)2.00056986
98Premature ovarian failure (HP:0008209)1.99862713
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.99730541
100Easy fatigability (HP:0003388)1.99723262
101Absent radius (HP:0003974)1.99722471
102Hypercortisolism (HP:0001578)1.99698387
103Granulocytopenia (HP:0001913)1.99093690
104Ragged-red muscle fibers (HP:0003200)1.98874765
105Panhypogammaglobulinemia (HP:0003139)1.97656983
106Rhabdomyosarcoma (HP:0002859)1.96911724
107Abnormality of the thoracic spine (HP:0100711)1.96131297
108Cerebral hypomyelination (HP:0006808)1.95652728
109Metaphyseal cupping (HP:0003021)1.94908272
110Fatigue (HP:0012378)1.93492657
111Diaphragmatic weakness (HP:0009113)1.91405043
112Rib fusion (HP:0000902)1.91166606
113Deep venous thrombosis (HP:0002625)1.90974208
114Abnormality of the fingertips (HP:0001211)1.90940185
115Polycythemia (HP:0001901)1.90656322
116Obstructive sleep apnea (HP:0002870)1.89290860
117Distal lower limb amyotrophy (HP:0008944)1.88366234
118Preauricular skin tag (HP:0000384)1.87581877
119Abnormality of the calcaneus (HP:0008364)1.86977914
120Squamous cell carcinoma (HP:0002860)1.86959064
121Recurrent cutaneous fungal infections (HP:0011370)1.86914327
122Chronic mucocutaneous candidiasis (HP:0002728)1.86914327
123Cholelithiasis (HP:0001081)1.86770443
124Spastic diplegia (HP:0001264)1.86617681
125Papilloma (HP:0012740)1.86281551
126Verrucae (HP:0200043)1.86281551
127Aplasia involving forearm bones (HP:0009822)1.85659147
128Absent forearm bone (HP:0003953)1.85659147
129Medulloblastoma (HP:0002885)1.85454053
130Glossoptosis (HP:0000162)1.85342340
131Hemorrhage of the eye (HP:0011885)1.84872707
132Rectal prolapse (HP:0002035)1.83976319
133Skin tags (HP:0010609)1.83814070
134Neoplasm of striated muscle (HP:0009728)1.83576482
135Disproportionate tall stature (HP:0001519)1.82970869
136Emphysema (HP:0002097)1.82809443
137Bulbar palsy (HP:0001283)1.81781795
138Pelvic girdle muscle weakness (HP:0003749)1.81585832
139Calcaneovalgus deformity (HP:0001848)1.81387172
140Optic neuritis (HP:0100653)1.79897710
141Retrobulbar optic neuritis (HP:0100654)1.79897710
142Increased density of long bones (HP:0006392)1.78975898
143Thrombocytosis (HP:0001894)1.78882726
144Muscle stiffness (HP:0003552)1.78867270
145Pseudobulbar signs (HP:0002200)1.78106338
146Gingivitis (HP:0000230)1.77820844
147Rhabdomyolysis (HP:0003201)1.77128023
148Slow saccadic eye movements (HP:0000514)1.76902430
149Ulnar bowing (HP:0003031)1.75763029
150Pustule (HP:0200039)1.74661091
151Chest pain (HP:0100749)1.74332702
152Microcytic anemia (HP:0001935)1.73983732
153Epistaxis (HP:0000421)1.72909950
154Achilles tendon contracture (HP:0001771)1.72616629
155Missing ribs (HP:0000921)1.72576244
156Gastrointestinal dysmotility (HP:0002579)1.72485373
157Restrictive lung disease (HP:0002091)1.69877597
158Difficulty climbing stairs (HP:0003551)1.68978077
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.67808863
160Shallow orbits (HP:0000586)1.67085562
161Short 5th finger (HP:0009237)1.66172272
162Abnormal cartilage morphology (HP:0002763)1.65415645
163Short 4th metacarpal (HP:0010044)1.65204834
164Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65204834
165Cerebral aneurysm (HP:0004944)1.64719000
166Hypertriglyceridemia (HP:0002155)1.64479939
167Hypergammaglobulinemia (HP:0010702)1.64081287
168Tracheoesophageal fistula (HP:0002575)1.63552099
169Deformed tarsal bones (HP:0008119)1.63504746
170High pitched voice (HP:0001620)1.62838785
171Abnormality of the peritoneum (HP:0002585)1.62700991
172Astrocytoma (HP:0009592)1.61176127
173Abnormality of the astrocytes (HP:0100707)1.61176127
174Abnormal neuron morphology (HP:0012757)1.61094039
175Abnormality of the motor neurons (HP:0002450)1.61094039
176Poikiloderma (HP:0001029)1.61067939
177Abnormality of the distal phalanges of the toes (HP:0010182)1.61041662
178Aplasia/hypoplasia of the humerus (HP:0006507)1.60692963
179Sparse lateral eyebrow (HP:0005338)1.60377006
180Abnormality of the Achilles tendon (HP:0005109)1.56874689
181Overriding aorta (HP:0002623)1.56428441
182Abnormal trabecular bone morphology (HP:0100671)1.56095995
183Hypoplasia of the radius (HP:0002984)1.55822150
184Prominent nose (HP:0000448)1.55723076
185Broad palm (HP:0001169)1.55391324
186Hallux valgus (HP:0001822)1.54836560
187Premature rupture of membranes (HP:0001788)1.54536399
188Abnormal umbilical cord blood vessels (HP:0011403)1.54528669
189Single umbilical artery (HP:0001195)1.54528669
190Abnormality of the fetal cardiovascular system (HP:0010948)1.54528669
191Cellular immunodeficiency (HP:0005374)1.54165347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.91857280
2SMG13.46808180
3TRIB33.41327177
4MAP3K103.11941837
5BUB13.10786437
6EEF2K2.97631463
7RIPK42.74556273
8PKN22.74357347
9WEE12.65306342
10MAP3K132.58828346
11NEK22.57188539
12NME22.51861867
13CDC72.47196001
14ERN12.28245304
15TESK22.21356080
16PASK2.05044384
17CDK122.00641129
18DYRK31.97053783
19ARAF1.87658626
20IRAK41.86077833
21PAK41.85547258
22MAP3K111.82388013
23RPS6KA41.68349994
24KSR21.65951903
25CDK71.62597175
26RPS6KB21.59547804
27EIF2AK11.58522430
28ICK1.58292328
29MAP4K11.57115165
30CDK41.56724396
31MAP3K91.54896841
32SCYL21.52582127
33MAP3K11.48178581
34TTK1.48148325
35NEK11.47189376
36MAP3K81.46177066
37STK101.44359924
38TYK21.44157750
39PIM21.42954540
40IRAK31.41191899
41LRRK21.35523475
42EPHB11.30328336
43TSSK61.30020272
44EPHA21.29250997
45CSK1.22081987
46PLK11.19734458
47MAP3K141.13427880
48ACVR1B1.10466577
49SIK31.10136351
50KDR1.09528379
51PTK61.09151489
52MAP2K21.08228587
53MAP2K31.07827483
54AURKA1.04791512
55ALK1.03832572
56JAK31.00675026
57AURKB0.99764019
58MAPKAPK30.99706496
59BCKDK0.98927167
60LATS20.98775251
61RIPK10.97898898
62BRAF0.97799917
63TGFBR10.97402200
64MTOR0.97278056
65MARK30.96577696
66TAOK10.96207219
67CDK190.94034911
68BRSK20.93920764
69MOS0.93234646
70FES0.92606257
71CDK60.90705231
72ZAP700.89365696
73TNK20.87547697
74TESK10.84506043
75EIF2AK30.83887086
76ILK0.83202119
77BMX0.83178563
78TAOK20.83148233
79ATR0.82899071
80GRK60.82742117
81PDPK10.80915117
82CHEK10.80716275
83FLT30.80562441
84PIM10.79813110
85MAPK120.79490484
86MKNK10.76884372
87PAK20.76222723
88PDGFRA0.74828523
89VRK20.74647809
90MARK20.74369668
91DYRK1B0.74041941
92CDC42BPA0.73492862
93CHEK20.72871976
94TYRO30.71038251
95PRKD20.68490982
96BRSK10.64469324
97SIK20.63722027
98IRAK20.63228990
99FGR0.63084681
100SRPK10.62777780
101HCK0.62457487
102MAPK110.60741328
103IKBKE0.60727608
104* PAK10.60596925
105RPS6KC10.60171847
106RPS6KL10.60171847
107* CDK20.60155050
108MAP3K30.60151373
109PDK10.58370682
110SYK0.57351676
111BLK0.55805119
112RAF10.55663200
113MKNK20.53839558
114SIK10.53211195
115FGFR40.52386973
116CSF1R0.51804170
117PRKCI0.51588100
118DDR20.50685630
119UHMK10.50656316
120RPS6KA10.48210444
121BTK0.48066894
122CDK90.47484082
123STK30.46914946
124FGFR30.46710452
125LYN0.45647734
126DMPK0.45487540
127CSNK2A20.44210995
128RPS6KA20.43672769
129FGFR10.42609376
130MATK0.42572494
131ITK0.42279806
132DYRK20.41863277
133PRKG20.41390214
134JAK20.41291914
135MAPKAPK20.40124658
136BRD40.39453816
137CSNK2A10.39075592
138STK40.38920894
139EPHB20.38812890
140CLK10.38552109
141PTK20.38006501
142YES10.37910224
143CDK80.36895389
144STK160.35976425
145TTN0.34276025
146* AKT20.31193262
147CSNK1E0.29744155
148HIPK20.29704132
149TBK10.29417113
150CDK10.29395366

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48538768
2Ribosome_Homo sapiens_hsa030103.54740942
3Mismatch repair_Homo sapiens_hsa034303.32993497
4* Spliceosome_Homo sapiens_hsa030403.25814615
5Base excision repair_Homo sapiens_hsa034103.06851640
6RNA transport_Homo sapiens_hsa030133.04504483
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89310133
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.73534186
9Cell cycle_Homo sapiens_hsa041102.44027876
10Proteasome_Homo sapiens_hsa030502.30712357
11One carbon pool by folate_Homo sapiens_hsa006702.30034442
12RNA polymerase_Homo sapiens_hsa030202.17816065
13Nucleotide excision repair_Homo sapiens_hsa034202.14495986
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91081448
15Pyrimidine metabolism_Homo sapiens_hsa002401.90870631
16Osteoclast differentiation_Homo sapiens_hsa043801.89898552
17mRNA surveillance pathway_Homo sapiens_hsa030151.88053494
18Homologous recombination_Homo sapiens_hsa034401.79522114
19Sulfur relay system_Homo sapiens_hsa041221.67923576
20T cell receptor signaling pathway_Homo sapiens_hsa046601.64811887
21Allograft rejection_Homo sapiens_hsa053301.62831379
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59404092
23p53 signaling pathway_Homo sapiens_hsa041151.55614966
24Autoimmune thyroid disease_Homo sapiens_hsa053201.50267399
25Folate biosynthesis_Homo sapiens_hsa007901.49525890
26Measles_Homo sapiens_hsa051621.49025628
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.48162762
28Other glycan degradation_Homo sapiens_hsa005111.43328516
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43202788
30Influenza A_Homo sapiens_hsa051641.41584253
31Biosynthesis of amino acids_Homo sapiens_hsa012301.38400200
32Graft-versus-host disease_Homo sapiens_hsa053321.38204602
33Tuberculosis_Homo sapiens_hsa051521.34027908
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.28598412
35Pentose phosphate pathway_Homo sapiens_hsa000301.25165949
36Thyroid cancer_Homo sapiens_hsa052161.24149638
37Staphylococcus aureus infection_Homo sapiens_hsa051501.22613561
38Bladder cancer_Homo sapiens_hsa052191.22051028
39RNA degradation_Homo sapiens_hsa030181.20709055
40Notch signaling pathway_Homo sapiens_hsa043301.15647033
41Hepatitis C_Homo sapiens_hsa051601.10029125
42Epstein-Barr virus infection_Homo sapiens_hsa051691.09734655
43Chronic myeloid leukemia_Homo sapiens_hsa052201.08884817
44Toxoplasmosis_Homo sapiens_hsa051451.08822718
45Chemokine signaling pathway_Homo sapiens_hsa040621.07487690
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06187321
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.04304902
48Selenocompound metabolism_Homo sapiens_hsa004501.01122721
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98859057
50Basal transcription factors_Homo sapiens_hsa030220.98064269
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97786127
52Hippo signaling pathway_Homo sapiens_hsa043900.97166879
53HTLV-I infection_Homo sapiens_hsa051660.96867520
54Prion diseases_Homo sapiens_hsa050200.95811617
55Insulin signaling pathway_Homo sapiens_hsa049100.95780858
56Antigen processing and presentation_Homo sapiens_hsa046120.95423889
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92907571
58Herpes simplex infection_Homo sapiens_hsa051680.92412258
59Acute myeloid leukemia_Homo sapiens_hsa052210.92238038
60Small cell lung cancer_Homo sapiens_hsa052220.91792460
61Basal cell carcinoma_Homo sapiens_hsa052170.91554265
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91444262
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.90949366
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90748782
65Carbon metabolism_Homo sapiens_hsa012000.90608106
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89928054
67Malaria_Homo sapiens_hsa051440.89822192
68Type I diabetes mellitus_Homo sapiens_hsa049400.89600058
69Shigellosis_Homo sapiens_hsa051310.85717881
70MicroRNAs in cancer_Homo sapiens_hsa052060.84428989
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.83754300
72TNF signaling pathway_Homo sapiens_hsa046680.83740587
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83585499
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82801760
75Hematopoietic cell lineage_Homo sapiens_hsa046400.80763430
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80656953
77Fanconi anemia pathway_Homo sapiens_hsa034600.80341515
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78984335
79Viral carcinogenesis_Homo sapiens_hsa052030.78642708
80Vitamin B6 metabolism_Homo sapiens_hsa007500.77013486
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76550553
82mTOR signaling pathway_Homo sapiens_hsa041500.75365486
83Legionellosis_Homo sapiens_hsa051340.74969146
84N-Glycan biosynthesis_Homo sapiens_hsa005100.74912350
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72011620
86Colorectal cancer_Homo sapiens_hsa052100.71873264
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70584895
88Phagosome_Homo sapiens_hsa041450.70325546
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.70225947
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.69533915
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69341641
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69135835
93Apoptosis_Homo sapiens_hsa042100.68468500
94Endocytosis_Homo sapiens_hsa041440.68387295
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.67098782
96Prolactin signaling pathway_Homo sapiens_hsa049170.66889415
97Salmonella infection_Homo sapiens_hsa051320.66410186
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64819117
99Purine metabolism_Homo sapiens_hsa002300.64105907
100Oocyte meiosis_Homo sapiens_hsa041140.63942068
101Adherens junction_Homo sapiens_hsa045200.62809673
102Hedgehog signaling pathway_Homo sapiens_hsa043400.62662482
103ErbB signaling pathway_Homo sapiens_hsa040120.60158882
104Glutathione metabolism_Homo sapiens_hsa004800.58857344
105Asthma_Homo sapiens_hsa053100.58201550
106FoxO signaling pathway_Homo sapiens_hsa040680.56813041
107Glioma_Homo sapiens_hsa052140.56309091
108Non-homologous end-joining_Homo sapiens_hsa034500.55931360
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55560097
110Hepatitis B_Homo sapiens_hsa051610.55434155
111GnRH signaling pathway_Homo sapiens_hsa049120.54854923
112Pertussis_Homo sapiens_hsa051330.52883627
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52494104
114Insulin resistance_Homo sapiens_hsa049310.51757169
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51277818
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51069258
117VEGF signaling pathway_Homo sapiens_hsa043700.50896462
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50253997
119TGF-beta signaling pathway_Homo sapiens_hsa043500.50018077
120Choline metabolism in cancer_Homo sapiens_hsa052310.49221734
121Platelet activation_Homo sapiens_hsa046110.49172284
122Galactose metabolism_Homo sapiens_hsa000520.48468689
123Arginine and proline metabolism_Homo sapiens_hsa003300.48092870
124Proteoglycans in cancer_Homo sapiens_hsa052050.47666153
125Viral myocarditis_Homo sapiens_hsa054160.47640160
126Non-small cell lung cancer_Homo sapiens_hsa052230.47242974
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.44589750
128Fructose and mannose metabolism_Homo sapiens_hsa000510.44342811
129Endometrial cancer_Homo sapiens_hsa052130.43473918
130Lysine degradation_Homo sapiens_hsa003100.43471086
131HIF-1 signaling pathway_Homo sapiens_hsa040660.41967733
132Pathways in cancer_Homo sapiens_hsa052000.40951270
133Pancreatic cancer_Homo sapiens_hsa052120.39558912
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39339139
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38217510
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37443169
137Fat digestion and absorption_Homo sapiens_hsa049750.34469242
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.34157428
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33582855
140B cell receptor signaling pathway_Homo sapiens_hsa046620.33191171
141Primary immunodeficiency_Homo sapiens_hsa053400.32776460
142Prostate cancer_Homo sapiens_hsa052150.31163322
143AMPK signaling pathway_Homo sapiens_hsa041520.31108285
144Renal cell carcinoma_Homo sapiens_hsa052110.30134743
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.30130985
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29752998
147Leishmaniasis_Homo sapiens_hsa051400.28265382
148Tight junction_Homo sapiens_hsa045300.27129717

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