PCBP2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mRNA cleavage (GO:0006379)6.54775130
2fatty acid elongation (GO:0030497)6.13110480
3response to muscle activity (GO:0014850)5.44834644
4rRNA methylation (GO:0031167)4.85695886
5positive regulation of catecholamine secretion (GO:0033605)4.82592367
6regulation of memory T cell differentiation (GO:0043380)4.77208603
7meiotic chromosome segregation (GO:0045132)4.71089938
8rRNA transcription (GO:0009303)4.46916109
9signal peptide processing (GO:0006465)4.32959419
10negative regulation of Rho protein signal transduction (GO:0035024)4.30521788
11coenzyme catabolic process (GO:0009109)4.26774507
12rRNA modification (GO:0000154)4.19663872
13negative regulation of defense response to virus (GO:0050687)3.91359869
14DNA strand renaturation (GO:0000733)3.89888328
15negative regulation of DNA recombination (GO:0045910)3.87778838
16regulation of meiosis I (GO:0060631)3.83836622
17synaptic transmission, cholinergic (GO:0007271)3.78130825
18germinal center formation (GO:0002467)3.75770521
19behavioral response to nicotine (GO:0035095)3.71869546
20response to acidic pH (GO:0010447)3.70936857
21negative regulation of viral entry into host cell (GO:0046597)3.68636309
22sulfate transport (GO:0008272)3.61402739
23regulation of germinal center formation (GO:0002634)3.55919126
24regulation of oxidative stress-induced neuron death (GO:1903203)3.55287911
25innate immune response in mucosa (GO:0002227)3.49969716
26negative regulation of B cell mediated immunity (GO:0002713)3.45087455
27negative regulation of immunoglobulin mediated immune response (GO:0002890)3.45087455
28positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.43064394
29growth hormone receptor signaling pathway (GO:0060396)3.39841993
30detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.36028181
31regulation of heat generation (GO:0031650)3.33094578
32peptidyl-histidine modification (GO:0018202)3.31960729
33DNA damage induced protein phosphorylation (GO:0006975)3.25982752
34cellular response to ATP (GO:0071318)3.24434187
35negative regulation of B cell apoptotic process (GO:0002903)3.23929660
36replication fork processing (GO:0031297)3.19452052
37mitotic sister chromatid segregation (GO:0000070)3.18695350
38detection of chemical stimulus involved in sensory perception (GO:0050907)3.13211140
39AMP metabolic process (GO:0046033)3.08928218
40motile cilium assembly (GO:0044458)3.08583057
41negative regulation of circadian rhythm (GO:0042754)3.08417051
42sensory perception of taste (GO:0050909)3.07573109
43cellular response to growth hormone stimulus (GO:0071378)3.02052202
44replicative senescence (GO:0090399)3.00067195
45histone H2B ubiquitination (GO:0033523)2.99164988
46negative regulation of thymocyte apoptotic process (GO:0070244)2.96066990
47regulation of viral entry into host cell (GO:0046596)2.96024271
48positive regulation of protein homodimerization activity (GO:0090073)2.95509543
49regulation of skeletal muscle contraction (GO:0014819)2.94866325
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93811270
51peptidyl-lysine trimethylation (GO:0018023)2.92821473
52iron ion import (GO:0097286)2.92177355
53mucosal immune response (GO:0002385)2.91672464
54sister chromatid segregation (GO:0000819)2.89751085
55phagocytosis, recognition (GO:0006910)2.89252722
56detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.89202108
57purinergic nucleotide receptor signaling pathway (GO:0035590)2.85988091
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85883328
59ADP metabolic process (GO:0046031)2.84160703
60regulation of hypersensitivity (GO:0002883)2.83965144
61monoubiquitinated protein deubiquitination (GO:0035520)2.81956090
62positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79364480
63IMP biosynthetic process (GO:0006188)2.78853159
64pseudouridine synthesis (GO:0001522)2.76197686
65multicellular organism reproduction (GO:0032504)2.75913890
66ribosome assembly (GO:0042255)2.73803527
67attachment of spindle microtubules to kinetochore (GO:0008608)2.71542387
68positive regulation of protein kinase C signaling (GO:0090037)2.71526823
69melanin metabolic process (GO:0006582)2.70398431
70folic acid-containing compound biosynthetic process (GO:0009396)2.69880639
71peptidyl-lysine methylation (GO:0018022)2.69065156
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69001200
73tetrahydrofolate metabolic process (GO:0046653)2.68665955
74sister chromatid cohesion (GO:0007062)2.67909820
75oxidative demethylation (GO:0070989)2.66721800
76transcription from RNA polymerase III promoter (GO:0006383)2.66007786
77myoblast migration (GO:0051451)2.62990837
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.62391972
79organ or tissue specific immune response (GO:0002251)2.59992611
80antibacterial humoral response (GO:0019731)2.59000117
81aspartate family amino acid catabolic process (GO:0009068)2.58070032
82RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.57438982
83histone H2A acetylation (GO:0043968)2.55069653
84melanin biosynthetic process (GO:0042438)2.54462866
85negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.53570369
86synaptonemal complex organization (GO:0070193)2.51580066
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.51104779
88DNA deamination (GO:0045006)2.51003248
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49199364
90negative regulation of T-helper cell differentiation (GO:0045623)2.49199364
91sulfate transmembrane transport (GO:1902358)2.48733162
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47985222
93muscle cell cellular homeostasis (GO:0046716)2.47870018
94negative regulation of JAK-STAT cascade (GO:0046426)2.47824651
95somite development (GO:0061053)2.47764642
96regulation of centrosome cycle (GO:0046605)2.47665013
97cellular response to pH (GO:0071467)2.47206831
98IMP metabolic process (GO:0046040)2.47201280
99regulation of centrosome duplication (GO:0010824)2.45895725
100tRNA modification (GO:0006400)2.44289004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.03622061
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.78663691
3NOTCH1_21737748_ChIP-Seq_TLL_Human4.37772128
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.24572376
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34247103
6CIITA_25753668_ChIP-Seq_RAJI_Human3.09374500
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02826264
8EWS_26573619_Chip-Seq_HEK293_Human2.62226866
9E2F7_22180533_ChIP-Seq_HELA_Human2.60436078
10ZNF274_21170338_ChIP-Seq_K562_Hela2.54503403
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46756343
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45397470
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34778394
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29588326
15ESR1_15608294_ChIP-ChIP_MCF-7_Human2.21854331
16VDR_23849224_ChIP-Seq_CD4+_Human2.20626197
17PKCTHETA_26484144_Chip-Seq_BREAST_Human2.19546742
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19500926
19GATA1_22025678_ChIP-Seq_K562_Human2.18054123
20VDR_22108803_ChIP-Seq_LS180_Human2.16101358
21DCP1A_22483619_ChIP-Seq_HELA_Human2.15878316
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.15830807
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.08885978
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02282534
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00951413
26FUS_26573619_Chip-Seq_HEK293_Human1.95381216
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93998300
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.90558411
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.87323744
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.81458268
31ELK1_19687146_ChIP-ChIP_HELA_Human1.77716306
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77581104
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74958643
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74829445
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61895602
36XRN2_22483619_ChIP-Seq_HELA_Human1.55006005
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50020139
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49714490
39E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45616965
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45492659
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45356063
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42739570
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42284034
44GBX2_23144817_ChIP-Seq_PC3_Human1.41861292
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41777931
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41662869
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41227911
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40374548
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40065161
50ER_23166858_ChIP-Seq_MCF-7_Human1.38371807
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.34351110
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32841948
53GABP_19822575_ChIP-Seq_HepG2_Human1.32799870
54TP53_22573176_ChIP-Seq_HFKS_Human1.32736983
55IGF1R_20145208_ChIP-Seq_DFB_Human1.30798595
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30023451
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22936205
58ERA_21632823_ChIP-Seq_H3396_Human1.21841940
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19021126
60CBP_20019798_ChIP-Seq_JUKART_Human1.19021126
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17749490
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17398185
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17062910
64AR_21572438_ChIP-Seq_LNCaP_Human1.15888529
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15689286
66FOXP3_21729870_ChIP-Seq_TREG_Human1.15347072
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14481426
68E2F1_20622854_ChIP-Seq_HELA_Human1.12102314
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.06461107
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.03054709
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02726930
72IRF1_19129219_ChIP-ChIP_H3396_Human0.98488636
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97833936
74POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96762107
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95899983
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95127354
77TTF2_22483619_ChIP-Seq_HELA_Human0.93956428
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92830142
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91296686
80GATA3_26560356_Chip-Seq_TH2_Human0.91000815
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90291913
82ESR1_20079471_ChIP-ChIP_T-47D_Human0.89644732
83BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.89358550
84THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88694006
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88235796
86ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88138434
87MYC_18940864_ChIP-ChIP_HL60_Human0.87712821
88MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86134814
89NANOG_20526341_ChIP-Seq_ESCs_Human0.84223546
90PHF8_20622854_ChIP-Seq_HELA_Human0.84208735
91CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82671427
92CHD1_26751641_Chip-Seq_LNCaP_Human0.81725558
93GATA6_25053715_ChIP-Seq_YYC3_Human0.81691726
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81512543
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.81125041
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78495614
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78376244
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77989870
99SOX9_26525672_Chip-Seq_HEART_Mouse0.77422529
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.77249051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.01781377
2MP0008057_abnormal_DNA_replication5.10433798
3MP0002138_abnormal_hepatobiliary_system5.07199318
4MP0004381_abnormal_hair_follicle4.28613433
5MP0003136_yellow_coat_color3.95696603
6MP0005171_absent_coat_pigmentation3.82879557
7MP0001986_abnormal_taste_sensitivity3.67318771
8MP0005174_abnormal_tail_pigmentation2.93926375
9MP0005423_abnormal_somatic_nervous2.42839552
10MP0003646_muscle_fatigue2.41831030
11MP0003693_abnormal_embryo_hatching2.38032082
12MP0004084_abnormal_cardiac_muscle2.34406620
13MP0002837_dystrophic_cardiac_calcinosis2.15356910
14MP0009697_abnormal_copulation2.12513039
15MP0000749_muscle_degeneration2.09661427
16MP0001188_hyperpigmentation2.05793173
17MP0001502_abnormal_circadian_rhythm1.86983780
18MP0004215_abnormal_myocardial_fiber1.85099204
19MP0010094_abnormal_chromosome_stability1.78847532
20MP0005075_abnormal_melanosome_morpholog1.71662959
21MP0003111_abnormal_nucleus_morphology1.71008655
22MP0000015_abnormal_ear_pigmentation1.64595247
23MP0002638_abnormal_pupillary_reflex1.61523008
24MP0001853_heart_inflammation1.58696997
25MP0004036_abnormal_muscle_relaxation1.58561549
26MP0004957_abnormal_blastocyst_morpholog1.56069158
27MP0005167_abnormal_blood-brain_barrier1.52344227
28MP0005266_abnormal_metabolism1.48019286
29MP0002254_reproductive_system_inflammat1.45898270
30MP0008875_abnormal_xenobiotic_pharmacok1.44534945
31MP0010234_abnormal_vibrissa_follicle1.43817967
32MP0004147_increased_porphyrin_level1.41059765
33MP0006054_spinal_hemorrhage1.35678519
34MP0008775_abnormal_heart_ventricle1.34851359
35MP0008007_abnormal_cellular_replicative1.31299778
36MP0005360_urolithiasis1.24481235
37MP0005083_abnormal_biliary_tract1.23706346
38MP0001968_abnormal_touch/_nociception1.22752184
39MP0002269_muscular_atrophy1.21030748
40MP0003077_abnormal_cell_cycle1.19102396
41MP0006036_abnormal_mitochondrial_physio1.16936503
42MP0003890_abnormal_embryonic-extraembry1.15352851
43MP0008058_abnormal_DNA_repair1.12839834
44MP0002006_tumorigenesis1.11779037
45MP0005330_cardiomyopathy1.11698034
46MP0005409_darkened_coat_color1.10318183
47MP0002166_altered_tumor_susceptibility1.06514877
48MP0002160_abnormal_reproductive_system1.05460728
49MP0000013_abnormal_adipose_tissue1.04983514
50MP0003786_premature_aging1.04523676
51MP0001984_abnormal_olfaction1.02056160
52MP0005646_abnormal_pituitary_gland1.01652004
53MP0001756_abnormal_urination1.00845910
54MP0005220_abnormal_exocrine_pancreas0.99360126
55MP0003879_abnormal_hair_cell0.97875404
56MP0008932_abnormal_embryonic_tissue0.96127467
57MP0000538_abnormal_urinary_bladder0.93909003
58MP0001835_abnormal_antigen_presentation0.92410874
59MP0003718_maternal_effect0.88581247
60MP0008770_decreased_survivor_rate0.88316193
61MP0004043_abnormal_pH_regulation0.86864657
62MP0002736_abnormal_nociception_after0.81139919
63MP0004233_abnormal_muscle_weight0.80485531
64MP0001929_abnormal_gametogenesis0.79397237
65MP0005187_abnormal_penis_morphology0.79039321
66MP0000569_abnormal_digit_pigmentation0.78323545
67MP0001542_abnormal_bone_strength0.76798765
68MP0001661_extended_life_span0.75179519
69MP0004858_abnormal_nervous_system0.73801454
70MP0002088_abnormal_embryonic_growth/wei0.73351083
71MP0003984_embryonic_growth_retardation0.72014968
72MP0005551_abnormal_eye_electrophysiolog0.69518321
73MP0008004_abnormal_stomach_pH0.68094377
74MP0006035_abnormal_mitochondrial_morpho0.67925918
75MP0003698_abnormal_male_reproductive0.67279545
76MP0003763_abnormal_thymus_physiology0.67076021
77MP0002332_abnormal_exercise_endurance0.66952959
78MP0005253_abnormal_eye_physiology0.66479718
79MP0005410_abnormal_fertilization0.65451806
80MP0001849_ear_inflammation0.65349742
81MP0001697_abnormal_embryo_size0.63766023
82MP0004085_abnormal_heartbeat0.63644104
83MP0000537_abnormal_urethra_morphology0.61699895
84MP0002115_abnormal_skeleton_extremities0.61197228
85MP0001672_abnormal_embryogenesis/_devel0.60082824
86MP0005380_embryogenesis_phenotype0.60082824
87MP0002210_abnormal_sex_determination0.59266554
88MP0004782_abnormal_surfactant_physiolog0.58567521
89MP0004197_abnormal_fetal_growth/weight/0.57327577
90MP0002132_abnormal_respiratory_system0.55286641
91MP0002084_abnormal_developmental_patter0.54253520
92MP0004145_abnormal_muscle_electrophysio0.53917003
93MP0009780_abnormal_chondrocyte_physiolo0.53873828
94MP0000613_abnormal_salivary_gland0.53558426
95MP0006276_abnormal_autonomic_nervous0.52420716
96MP0005376_homeostasis/metabolism_phenot0.51095459
97MP0008872_abnormal_physiological_respon0.50923797
98MP0005377_hearing/vestibular/ear_phenot0.50395186
99MP0003878_abnormal_ear_physiology0.50395186
100MP0000427_abnormal_hair_cycle0.50237902

Predicted human phenotypes

RankGene SetZ-score
1Clumsiness (HP:0002312)4.77936233
2Elevated erythrocyte sedimentation rate (HP:0003565)4.70455536
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.31017923
4Abnormality of alanine metabolism (HP:0010916)4.31017923
5Hyperalaninemia (HP:0003348)4.31017923
6Abnormality of the fingertips (HP:0001211)4.29555707
7Cerebellar dysplasia (HP:0007033)4.00085359
8Congenital stationary night blindness (HP:0007642)3.82480384
9Large eyes (HP:0001090)3.51371866
10Methylmalonic acidemia (HP:0002912)3.48935868
11Abnormality of the vitamin B12 metabolism (HP:0004341)3.36137334
12Hypoplasia of the pons (HP:0012110)3.35593273
13Clubbing of toes (HP:0100760)3.33790898
14Attenuation of retinal blood vessels (HP:0007843)3.25663775
15Sensory axonal neuropathy (HP:0003390)3.23040571
16Abnormality of the pons (HP:0007361)3.20368105
17Reduced subcutaneous adipose tissue (HP:0003758)3.14449755
18Abnormality of vitamin B metabolism (HP:0004340)3.04851852
19Methylmalonic aciduria (HP:0012120)2.96891758
203-Methylglutaconic aciduria (HP:0003535)2.94540856
21Small hand (HP:0200055)2.82164532
22Prominent nose (HP:0000448)2.81032012
23Testicular atrophy (HP:0000029)2.79066551
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78807816
25Chromsome breakage (HP:0040012)2.76339768
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76095986
27Ileus (HP:0002595)2.73266109
28Short chin (HP:0000331)2.69000829
29Poor head control (HP:0002421)2.66624265
30Reduced antithrombin III activity (HP:0001976)2.66024679
31Decreased circulating renin level (HP:0003351)2.63664666
32Facial hemangioma (HP:0000329)2.62725644
33Type II lissencephaly (HP:0007260)2.61064440
34Chronic otitis media (HP:0000389)2.60237198
35Squamous cell carcinoma (HP:0002860)2.57725574
36Flat occiput (HP:0005469)2.54275555
37Basal ganglia calcification (HP:0002135)2.46011852
38Chronic hepatic failure (HP:0100626)2.43082683
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.43000369
40Eosinophilia (HP:0001880)2.39301094
41Abnormality of the intrinsic pathway (HP:0010989)2.39153921
42Aplasia/Hypoplasia involving the musculature (HP:0001460)2.38834654
43Poikiloderma (HP:0001029)2.37545831
44Fetal akinesia sequence (HP:0001989)2.31697739
45Popliteal pterygium (HP:0009756)2.30908601
46Absent radius (HP:0003974)2.28215345
47Premature graying of hair (HP:0002216)2.27772407
48Absent thumb (HP:0009777)2.25199630
49Abnormality of homocysteine metabolism (HP:0010919)2.21748889
50Homocystinuria (HP:0002156)2.21748889
51Hypoplasia of the radius (HP:0002984)2.18160553
52Polydipsia (HP:0001959)2.17817536
53Abnormal drinking behavior (HP:0030082)2.17817536
54Dyschromatopsia (HP:0007641)2.15316240
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13887135
56Elbow flexion contracture (HP:0002987)2.13636546
57Aplasia involving forearm bones (HP:0009822)2.10227261
58Absent forearm bone (HP:0003953)2.10227261
59Hypoplasia of the ulna (HP:0003022)2.09998497
60Facial diplegia (HP:0001349)2.09217470
61Inability to walk (HP:0002540)2.09157274
62Rectal fistula (HP:0100590)2.07950680
63Rectovaginal fistula (HP:0000143)2.07950680
64Birth length less than 3rd percentile (HP:0003561)2.07849957
65Abnormality of the ileum (HP:0001549)2.07724976
66Congenital sensorineural hearing impairment (HP:0008527)2.07430880
67Pendular nystagmus (HP:0012043)2.07170273
68Horizontal nystagmus (HP:0000666)2.05509305
69Meckel diverticulum (HP:0002245)2.04885498
70Hypoalbuminemia (HP:0003073)2.04770195
71Abnormal albumin level (HP:0012116)2.04770195
72Abnormality of the shoulder girdle musculature (HP:0001435)2.04324750
73Aplastic anemia (HP:0001915)2.04093366
74Progressive external ophthalmoplegia (HP:0000590)1.98109022
75Wide intermamillary distance (HP:0006610)1.97999095
76Intestinal fistula (HP:0100819)1.97860352
77Capillary hemangiomas (HP:0005306)1.97854735
78Patellar aplasia (HP:0006443)1.95421203
79Chorioretinal atrophy (HP:0000533)1.94873703
80Abnormality of chromosome stability (HP:0003220)1.94110356
81Aplasia/Hypoplasia of the patella (HP:0006498)1.93736612
82Abnormality of the columella (HP:0009929)1.91243907
83Chronic sinusitis (HP:0011109)1.90181718
84Aplasia/Hypoplasia of the ulna (HP:0006495)1.88942554
85Abnormality of eosinophils (HP:0001879)1.87057948
86Short thumb (HP:0009778)1.86954967
87Cystic hygroma (HP:0000476)1.86020077
88Bony spicule pigmentary retinopathy (HP:0007737)1.85143644
89Aplasia of the musculature (HP:0100854)1.84544905
90Cleft eyelid (HP:0000625)1.84456865
91Abnormality of vitamin metabolism (HP:0100508)1.83199401
92Scapular winging (HP:0003691)1.82553708
93Non-midline cleft lip (HP:0100335)1.81363828
94Abnormality of the costochondral junction (HP:0000919)1.81066899
95Increased number of teeth (HP:0011069)1.80615695
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78635496
97Abnormal lung lobation (HP:0002101)1.78243134
98Rib fusion (HP:0000902)1.77887748
99Macroglossia (HP:0000158)1.77298063
100Atonic seizures (HP:0010819)1.77041853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.61176932
2FRK3.66065294
3ZAK3.43510026
4MARK33.15814017
5TLK12.94003672
6WNK42.88002887
7ACVR1B2.72887294
8DYRK32.54578592
9LATS12.27066523
10OBSCN2.18488857
11BMPR1B2.08862854
12NEK22.00089573
13PBK1.87984998
14SIK21.87305459
15EIF2AK31.82197833
16NEK11.81626512
17MST41.79244126
18SRPK11.76015988
19NLK1.74778563
20TXK1.61377904
21AKT31.60475681
22ADRBK21.58785802
23TSSK61.56181603
24NME21.48299276
25CDK121.47034208
26MKNK21.44483952
27IRAK21.42270010
28IRAK11.39282695
29MELK1.33285040
30BRD41.32085354
31EEF2K1.29034935
32MAPK151.27980785
33PDK21.22929475
34ATR1.22898787
35CHUK1.12590645
36CSNK1A1L1.11379023
37TAF11.11328540
38RPS6KA51.09665882
39CSNK1G11.09544077
40CSNK1G31.05475333
41MAP3K51.01193294
42PLK30.99593560
43MKNK10.93810806
44SGK20.91983724
45SGK2230.90004666
46SGK4940.90004666
47SCYL20.85860722
48MAP3K140.82871630
49NUAK10.82869110
50BUB10.80520547
51EPHA30.79335361
52STK38L0.76599959
53RPS6KB10.74217302
54PLK10.73685235
55IKBKB0.73422684
56AURKB0.73356953
57ATM0.72945175
58CCNB10.71787573
59CSNK1G20.70762199
60STK30.67834443
61TRPM70.65970737
62WEE10.65867073
63STK390.64402259
64AKT20.64012891
65PRKAA10.63777079
66MAPK110.63611187
67TGFBR10.61536429
68TNIK0.59507085
69TTK0.57109518
70MUSK0.56636707
71GRK10.56602550
72CHEK20.55729857
73CHEK10.55031620
74ALK0.54782841
75PKN10.54033149
76MAP3K90.53835050
77SGK30.52595990
78OXSR10.51171219
79MAPKAPK30.50337928
80ADRBK10.49248240
81RPS6KA10.49193728
82WNK10.48455568
83ERBB40.47608012
84STK40.47181190
85VRK10.45972374
86MAP4K10.44971626
87MAP3K10.43350701
88NEK90.42441808
89MAP3K80.40132910
90CSNK1D0.37582009
91MAP2K70.36862509
92LATS20.35984026
93PRKG20.35592872
94BRSK20.34242885
95MST1R0.34197717
96MAPKAPK50.33749629
97MAP2K30.33242301
98TIE10.32551121
99EIF2AK20.30843763
100ZAP700.30104705

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.18049854
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82299607
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.70771486
4Alcoholism_Homo sapiens_hsa050343.55302793
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.89242608
6Circadian rhythm_Homo sapiens_hsa047102.84919568
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.79932190
8Basal transcription factors_Homo sapiens_hsa030222.72163517
9One carbon pool by folate_Homo sapiens_hsa006702.58603667
10Nitrogen metabolism_Homo sapiens_hsa009102.38830822
11Olfactory transduction_Homo sapiens_hsa047402.34841283
12Viral carcinogenesis_Homo sapiens_hsa052032.34083178
13Fanconi anemia pathway_Homo sapiens_hsa034602.21776606
14RNA polymerase_Homo sapiens_hsa030202.18417665
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12270323
16Sulfur relay system_Homo sapiens_hsa041221.95368135
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94629395
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77308814
19RNA transport_Homo sapiens_hsa030131.62787497
20Lysine degradation_Homo sapiens_hsa003101.56718751
21Taste transduction_Homo sapiens_hsa047421.52974898
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38073927
23Homologous recombination_Homo sapiens_hsa034401.27898639
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27173881
25Propanoate metabolism_Homo sapiens_hsa006401.25721855
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15497332
27TGF-beta signaling pathway_Homo sapiens_hsa043501.14601562
28RNA degradation_Homo sapiens_hsa030181.14399687
29ABC transporters_Homo sapiens_hsa020101.12212155
30mRNA surveillance pathway_Homo sapiens_hsa030151.12193710
31Purine metabolism_Homo sapiens_hsa002301.11726431
32Proteasome_Homo sapiens_hsa030501.10197614
33p53 signaling pathway_Homo sapiens_hsa041151.09545517
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08192507
35DNA replication_Homo sapiens_hsa030301.07277904
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05595846
37Selenocompound metabolism_Homo sapiens_hsa004501.05040841
38Fatty acid elongation_Homo sapiens_hsa000621.04586336
39Pyrimidine metabolism_Homo sapiens_hsa002401.04217685
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99826686
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95005328
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91012016
43FoxO signaling pathway_Homo sapiens_hsa040680.85845158
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.85385025
45Antigen processing and presentation_Homo sapiens_hsa046120.83481156
46Hedgehog signaling pathway_Homo sapiens_hsa043400.81829564
47Chemical carcinogenesis_Homo sapiens_hsa052040.81678946
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77107372
49Cell cycle_Homo sapiens_hsa041100.74745102
50Non-homologous end-joining_Homo sapiens_hsa034500.73454774
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72551508
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70215157
53beta-Alanine metabolism_Homo sapiens_hsa004100.70059353
54Spliceosome_Homo sapiens_hsa030400.69359342
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67345718
56Herpes simplex infection_Homo sapiens_hsa051680.63658419
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.60369723
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.60177495
59Nucleotide excision repair_Homo sapiens_hsa034200.58978102
60Hippo signaling pathway_Homo sapiens_hsa043900.57931239
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53727801
62Base excision repair_Homo sapiens_hsa034100.50224326
63Arginine and proline metabolism_Homo sapiens_hsa003300.49424469
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47956141
65Mineral absorption_Homo sapiens_hsa049780.46384328
66Regulation of autophagy_Homo sapiens_hsa041400.44474989
67Dorso-ventral axis formation_Homo sapiens_hsa043200.43239924
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42873068
69Fructose and mannose metabolism_Homo sapiens_hsa000510.42869711
70Primary immunodeficiency_Homo sapiens_hsa053400.41075894
71Phototransduction_Homo sapiens_hsa047440.38144538
72Butanoate metabolism_Homo sapiens_hsa006500.37295074
73Calcium signaling pathway_Homo sapiens_hsa040200.36515636
74Pyruvate metabolism_Homo sapiens_hsa006200.35757096
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35126229
76Epstein-Barr virus infection_Homo sapiens_hsa051690.34156228
77Peroxisome_Homo sapiens_hsa041460.30975587
78Oocyte meiosis_Homo sapiens_hsa041140.30335320
79Prostate cancer_Homo sapiens_hsa052150.29455657
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27720421
81HTLV-I infection_Homo sapiens_hsa051660.25991009
82Protein digestion and absorption_Homo sapiens_hsa049740.25674758
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22084925
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20949141
85Glutathione metabolism_Homo sapiens_hsa004800.20228581
86Arginine biosynthesis_Homo sapiens_hsa002200.19522642
87Fatty acid biosynthesis_Homo sapiens_hsa000610.19387298
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19246206
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18861925
90Metabolic pathways_Homo sapiens_hsa011000.18169332
91AMPK signaling pathway_Homo sapiens_hsa041520.17435583
92Morphine addiction_Homo sapiens_hsa050320.17271406
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.16663213
94MAPK signaling pathway_Homo sapiens_hsa040100.16502033
95Oxytocin signaling pathway_Homo sapiens_hsa049210.15319422
96Linoleic acid metabolism_Homo sapiens_hsa005910.15008909
97Vitamin digestion and absorption_Homo sapiens_hsa049770.14232905
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13415828
99Sphingolipid metabolism_Homo sapiens_hsa006000.12105457
100Apoptosis_Homo sapiens_hsa042100.12060319

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