PCBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)6.25117365
2detection of light stimulus involved in visual perception (GO:0050908)6.25117365
3response to pheromone (GO:0019236)6.09310725
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54451399
5retinal rod cell development (GO:0046548)5.32256744
6synaptic vesicle exocytosis (GO:0016079)5.09047131
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07022961
8synaptic vesicle maturation (GO:0016188)4.99867333
9rhodopsin mediated signaling pathway (GO:0016056)4.90393837
10regulation of rhodopsin mediated signaling pathway (GO:0022400)4.81907145
11retinal cone cell development (GO:0046549)4.70749202
12regulation of synaptic vesicle exocytosis (GO:2000300)4.70520277
13cellular potassium ion homeostasis (GO:0030007)4.67737049
14protein localization to synapse (GO:0035418)4.61786436
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.42774726
16photoreceptor cell development (GO:0042461)4.42403516
17innervation (GO:0060384)4.41930947
18sodium ion export (GO:0071436)4.34009753
19negative regulation of cytosolic calcium ion concentration (GO:0051481)4.24340285
20eye photoreceptor cell development (GO:0042462)4.21786306
21detection of temperature stimulus (GO:0016048)4.17444493
22cell migration in hindbrain (GO:0021535)4.16440237
23glutamate secretion (GO:0014047)4.10950176
24detection of temperature stimulus involved in sensory perception (GO:0050961)4.05309315
25detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.05309315
26regulation of synaptic vesicle transport (GO:1902803)3.97782029
27membrane depolarization during action potential (GO:0086010)3.96562762
28urinary tract smooth muscle contraction (GO:0014848)3.93643845
29potassium ion homeostasis (GO:0055075)3.89279239
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87522646
31photoreceptor cell maintenance (GO:0045494)3.82503062
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73435446
33acrosome reaction (GO:0007340)3.70340313
34synaptic vesicle endocytosis (GO:0048488)3.68708118
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.65426293
36axon cargo transport (GO:0008088)3.59751997
37positive regulation of synapse maturation (GO:0090129)3.58954533
38postsynaptic membrane organization (GO:0001941)3.52279327
39neurotransmitter secretion (GO:0007269)3.46239502
40cell communication by electrical coupling (GO:0010644)3.46082744
41piRNA metabolic process (GO:0034587)3.43833448
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42588743
43potassium ion export (GO:0071435)3.39064237
44transmission of nerve impulse (GO:0019226)3.38468319
45behavioral response to ethanol (GO:0048149)3.38240677
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.37027384
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36073021
48regulation of neurotransmitter secretion (GO:0046928)3.34003516
49gamma-aminobutyric acid transport (GO:0015812)3.32449295
50GMP metabolic process (GO:0046037)3.31650833
51neurofilament cytoskeleton organization (GO:0060052)3.31389734
52reflex (GO:0060004)3.28754334
53mating behavior (GO:0007617)3.25957822
54calcium ion-dependent exocytosis (GO:0017156)3.23418592
55membrane hyperpolarization (GO:0060081)3.21004875
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19601532
57neuron cell-cell adhesion (GO:0007158)3.19151398
58regulation of voltage-gated calcium channel activity (GO:1901385)3.18248606
59cerebellar Purkinje cell differentiation (GO:0021702)3.15611273
60pyrimidine nucleobase catabolic process (GO:0006208)3.14000693
61sperm motility (GO:0030317)3.13402470
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.12754884
63retinal ganglion cell axon guidance (GO:0031290)3.12130552
64DNA methylation involved in gamete generation (GO:0043046)3.11371983
65neurotransmitter transport (GO:0006836)3.10923236
66negative regulation of microtubule polymerization (GO:0031115)3.07330447
67regulation of neurotransmitter transport (GO:0051588)3.06445350
68detection of light stimulus (GO:0009583)3.05712070
69peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.05633255
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05472099
71visual perception (GO:0007601)3.02270601
72auditory behavior (GO:0031223)3.02130273
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02071394
74sensory perception of light stimulus (GO:0050953)3.01251823
75behavioral response to nicotine (GO:0035095)2.99719758
76synaptic vesicle transport (GO:0048489)2.99540584
77establishment of synaptic vesicle localization (GO:0097480)2.99540584
78positive regulation of amine transport (GO:0051954)2.99367093
79multicellular organism reproduction (GO:0032504)2.99321490
80protein K11-linked deubiquitination (GO:0035871)2.98946703
81regulation of neurotransmitter uptake (GO:0051580)2.97401025
82membrane repolarization (GO:0086009)2.95814770
83regulation of vesicle fusion (GO:0031338)2.92640114
84cilium or flagellum-dependent cell motility (GO:0001539)2.92074439
85sympathetic nervous system development (GO:0048485)2.91835704
86cellular sodium ion homeostasis (GO:0006883)2.90963027
87vocalization behavior (GO:0071625)2.90718705
88regulation of transmission of nerve impulse (GO:0051969)2.90454659
89retina development in camera-type eye (GO:0060041)2.90335443
90protein localization to cilium (GO:0061512)2.89560702
91detection of visible light (GO:0009584)2.89046209
92neuronal action potential (GO:0019228)2.88495714
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.88402864
94glycosphingolipid biosynthetic process (GO:0006688)2.87704398
95negative regulation of cation channel activity (GO:2001258)2.87133770
96synaptic transmission, glutamatergic (GO:0035249)2.86340654
97neuromuscular process controlling posture (GO:0050884)2.85147001
98tachykinin receptor signaling pathway (GO:0007217)2.84602341
99regulation of cilium movement (GO:0003352)2.84562484
100layer formation in cerebral cortex (GO:0021819)2.84371379
101glutamate receptor signaling pathway (GO:0007215)2.83609113
102neuromuscular synaptic transmission (GO:0007274)2.82903577
103neural tube formation (GO:0001841)2.82100114
104response to acidic pH (GO:0010447)2.81643074
105photoreceptor cell differentiation (GO:0046530)2.79908877
106eye photoreceptor cell differentiation (GO:0001754)2.79908877
107calcium ion import (GO:0070509)2.79809895
108protein polyglutamylation (GO:0018095)2.79443134
109aggressive behavior (GO:0002118)2.78937143
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77953501
111neuronal action potential propagation (GO:0019227)2.77589968
112proline transport (GO:0015824)2.76620285
113exploration behavior (GO:0035640)2.76172680
114regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.75910680
115regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.75910680
116neuron-neuron synaptic transmission (GO:0007270)2.75777146
117negative regulation of dendrite morphogenesis (GO:0050774)2.74811874
118nucleobase catabolic process (GO:0046113)2.74554552
119microtubule-based transport (GO:0010970)2.73797973
120protein-chromophore linkage (GO:0018298)2.73760301
121anterograde axon cargo transport (GO:0008089)2.73120678
122locomotory exploration behavior (GO:0035641)2.72854955
123synapse assembly (GO:0007416)2.72763106
124indolalkylamine metabolic process (GO:0006586)2.72620406
125establishment of vesicle localization (GO:0051650)2.71977270
126L-fucose catabolic process (GO:0042355)2.71352556
127fucose catabolic process (GO:0019317)2.71352556
128L-fucose metabolic process (GO:0042354)2.71352556
129central nervous system neuron axonogenesis (GO:0021955)2.68407624
130phototransduction (GO:0007602)2.67972893
131potassium ion transmembrane transport (GO:0071805)2.67898070
132indole-containing compound catabolic process (GO:0042436)2.67885163
133indolalkylamine catabolic process (GO:0046218)2.67885163
134tryptophan catabolic process (GO:0006569)2.67885163
135regulation of action potential (GO:0098900)2.65532106
136establishment of protein localization to Golgi (GO:0072600)2.65339521
137regulation of meiosis I (GO:0060631)2.63032530
138positive regulation of neurotransmitter transport (GO:0051590)2.62449470
139cellular ketone body metabolic process (GO:0046950)2.62376887
140presynaptic membrane assembly (GO:0097105)2.61931471
141ionotropic glutamate receptor signaling pathway (GO:0035235)2.60780368
142adult walking behavior (GO:0007628)2.60042943
143regulation of glutamate secretion (GO:0014048)2.59750630
144mechanosensory behavior (GO:0007638)2.59598283
145phosphorelay signal transduction system (GO:0000160)2.57994292
146auditory receptor cell stereocilium organization (GO:0060088)2.57636585
147startle response (GO:0001964)2.55620160
148regulation of female receptivity (GO:0045924)2.54708799
149membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54619501
150positive regulation of meiosis (GO:0045836)2.54567839
151kynurenine metabolic process (GO:0070189)2.53588417
152regulation of synaptic transmission, glutamatergic (GO:0051966)2.53290185
153DNA double-strand break processing (GO:0000729)2.52934749
154righting reflex (GO:0060013)2.52320040
155presynaptic membrane organization (GO:0097090)2.48954577
156central nervous system projection neuron axonogenesis (GO:0021952)2.48954404
157regulation of female gonad development (GO:2000194)2.48911138
158positive regulation of neurotransmitter secretion (GO:0001956)2.48085844
159negative regulation of cAMP-mediated signaling (GO:0043951)2.45342771
160positive regulation of amino acid transport (GO:0051957)2.44987783
161detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42272779
162male meiosis (GO:0007140)2.41542979
163seminiferous tubule development (GO:0072520)2.41243108
164regulation of translation, ncRNA-mediated (GO:0045974)2.40861817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05658552
2REST_21632747_ChIP-Seq_MESCs_Mouse3.04752465
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93048657
4GBX2_23144817_ChIP-Seq_PC3_Human2.89843733
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64427009
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51079811
7* REST_18959480_ChIP-ChIP_MESCs_Mouse2.51073654
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49490439
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41289848
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.34632997
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33525461
12SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27433460
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25925945
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21298710
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19281108
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.19155152
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13484817
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13484817
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10012658
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09261826
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07782632
22DROSHA_22980978_ChIP-Seq_HELA_Human2.06551906
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05584426
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02731784
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.97804572
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.95959976
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92887426
28ER_23166858_ChIP-Seq_MCF-7_Human1.90073275
29VDR_22108803_ChIP-Seq_LS180_Human1.83673824
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81981956
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80155700
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77746156
33CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.77006295
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.74064913
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72075079
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71771349
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70240987
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70110870
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69603437
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63125524
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.61224164
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59360392
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58852103
44ZNF274_21170338_ChIP-Seq_K562_Hela1.56906362
45FUS_26573619_Chip-Seq_HEK293_Human1.53643379
46SMAD4_21799915_ChIP-Seq_A2780_Human1.53268010
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52558036
48* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51102083
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50455304
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50455304
51IGF1R_20145208_ChIP-Seq_DFB_Human1.49272729
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43513337
53* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43024696
54TAF15_26573619_Chip-Seq_HEK293_Human1.41904803
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.41493419
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39436971
57RNF2_27304074_Chip-Seq_NSC_Mouse1.38954766
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37248619
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.36762928
60RUNX2_22187159_ChIP-Seq_PCA_Human1.36486002
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36189674
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34562633
63CTCF_27219007_Chip-Seq_Bcells_Human1.32599003
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32522438
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30866187
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29539246
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29507254
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.28042663
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26036770
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23187591
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23187540
72EWS_26573619_Chip-Seq_HEK293_Human1.22964615
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.22523279
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20878661
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19842084
76TP53_22573176_ChIP-Seq_HFKS_Human1.19429984
77TCF4_22108803_ChIP-Seq_LS180_Human1.17390579
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16873659
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16639107
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.16208664
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.14560210
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13859268
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13786791
84NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.13616576
85* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13546917
86STAT3_23295773_ChIP-Seq_U87_Human1.12598826
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.12188295
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11982311
89ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11967937
90AR_25329375_ChIP-Seq_VCAP_Human1.11321554
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10873503
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10438770
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10102070
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09272125
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.08812326
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07316356
97* AR_19668381_ChIP-Seq_PC3_Human1.07002548
98P300_19829295_ChIP-Seq_ESCs_Human1.06105084
99NANOG_19829295_ChIP-Seq_ESCs_Human1.05757260
100SOX2_19829295_ChIP-Seq_ESCs_Human1.05757260
101* EZH2_27294783_Chip-Seq_NPCs_Mouse1.05620355
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05501604
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05480545
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05003430
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04709671
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04354362
107* FLI1_21867929_ChIP-Seq_TH2_Mouse1.04121761
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04031933
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.03704242
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02958740
111CBP_20019798_ChIP-Seq_JUKART_Human1.02958740
112* ARNT_22903824_ChIP-Seq_MCF-7_Human1.02932581
113* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02815073
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01688346
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01228792
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99985225
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.99619271
118* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99592553
119* KDM2B_26808549_Chip-Seq_K562_Human0.99356631
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98562906
121IRF1_19129219_ChIP-ChIP_H3396_Human0.98315682
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98295606
123* TCF4_23295773_ChIP-Seq_U87_Human0.98052586
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96319806
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.95905414
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95550525
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.95382395
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91024294
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.90606893
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89610299
131BCAT_22108803_ChIP-Seq_LS180_Human0.89173516
132AR_21572438_ChIP-Seq_LNCaP_Human0.87939351
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87252307
134KDM2B_26808549_Chip-Seq_REH_Human0.86972665
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86889902
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86269387
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.85445443
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.84585971
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84341782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.56522624
2MP0006072_abnormal_retinal_apoptosis3.41969958
3MP0002735_abnormal_chemical_nociception3.36556337
4MP0001968_abnormal_touch/_nociception3.36454192
5MP0004270_analgesia3.20529053
6MP0004859_abnormal_synaptic_plasticity2.98225889
7MP0002638_abnormal_pupillary_reflex2.97098225
8MP0005253_abnormal_eye_physiology2.86381381
9MP0002734_abnormal_mechanical_nocicepti2.77454259
10MP0002736_abnormal_nociception_after2.72049497
11MP0001984_abnormal_olfaction2.65887922
12MP0005410_abnormal_fertilization2.64613224
13MP0002653_abnormal_ependyma_morphology2.52588985
14MP0004858_abnormal_nervous_system2.49556586
15MP0003635_abnormal_synaptic_transmissio2.48672827
16MP0005423_abnormal_somatic_nervous2.44794496
17MP0006276_abnormal_autonomic_nervous2.43474898
18MP0003011_delayed_dark_adaptation2.40750894
19MP0003880_abnormal_central_pattern2.27519544
20MP0001986_abnormal_taste_sensitivity2.23467350
21MP0010386_abnormal_urinary_bladder2.21335278
22MP0002090_abnormal_vision2.18260593
23MP0009046_muscle_twitch2.18053044
24MP0002272_abnormal_nervous_system2.16642453
25MP0002733_abnormal_thermal_nociception2.12974829
26MP0001502_abnormal_circadian_rhythm2.07075061
27MP0001970_abnormal_pain_threshold2.05248359
28MP0002184_abnormal_innervation2.05213459
29MP0004233_abnormal_muscle_weight2.00588386
30MP0002822_catalepsy2.00336667
31MP0002063_abnormal_learning/memory/cond1.92206665
32MP0002064_seizures1.88240163
33MP0009745_abnormal_behavioral_response1.86684457
34MP0002067_abnormal_sensory_capabilities1.80996493
35MP0005195_abnormal_posterior_eye1.78937593
36MP0002229_neurodegeneration1.74589637
37MP0002909_abnormal_adrenal_gland1.68207822
38MP0002751_abnormal_autonomic_nervous1.67934272
39MP0002572_abnormal_emotion/affect_behav1.67328172
40MP0002882_abnormal_neuron_morphology1.62109652
41MP0002752_abnormal_somatic_nervous1.60283703
42MP0002102_abnormal_ear_morphology1.58163620
43MP0004811_abnormal_neuron_physiology1.53478336
44MP0001486_abnormal_startle_reflex1.51225677
45MP0000955_abnormal_spinal_cord1.50813956
46MP0005499_abnormal_olfactory_system1.41337935
47MP0005394_taste/olfaction_phenotype1.41337935
48MP0003698_abnormal_male_reproductive1.35126373
49MP0008569_lethality_at_weaning1.29767377
50MP0001324_abnormal_eye_pigmentation1.27367541
51MP0005167_abnormal_blood-brain_barrier1.26831194
52MP0008877_abnormal_DNA_methylation1.23604246
53MP0001440_abnormal_grooming_behavior1.21671216
54MP0005391_vision/eye_phenotype1.20926449
55MP0000569_abnormal_digit_pigmentation1.19900342
56MP0006292_abnormal_olfactory_placode1.18669166
57MP0008789_abnormal_olfactory_epithelium1.18608942
58MP0000778_abnormal_nervous_system1.17942809
59MP0003195_calcinosis1.16760741
60MP0004381_abnormal_hair_follicle1.15920315
61MP0000427_abnormal_hair_cycle1.14742388
62MP0003329_amyloid_beta_deposits1.13617066
63MP0002557_abnormal_social/conspecific_i1.12178536
64MP0000534_abnormal_ureter_morphology1.11530549
65MP0000372_irregular_coat_pigmentation1.10881531
66MP0008057_abnormal_DNA_replication1.10302800
67MP0001529_abnormal_vocalization1.09797429
68MP0003122_maternal_imprinting1.08126597
69MP0004924_abnormal_behavior1.07340892
70MP0005386_behavior/neurological_phenoty1.07340892
71MP0003787_abnormal_imprinting1.06805659
72MP0003879_abnormal_hair_cell1.05712835
73MP0001485_abnormal_pinna_reflex1.05608961
74MP0005670_abnormal_white_adipose1.03725993
75MP0001501_abnormal_sleep_pattern1.03410520
76MP0004147_increased_porphyrin_level1.00776252
77MP0002837_dystrophic_cardiac_calcinosis0.99002977
78MP0003252_abnormal_bile_duct0.98679096
79MP0002876_abnormal_thyroid_physiology0.96473303
80MP0002066_abnormal_motor_capabilities/c0.96302447
81MP0004145_abnormal_muscle_electrophysio0.95272557
82MP0000631_abnormal_neuroendocrine_gland0.94363395
83MP0001270_distended_abdomen0.93028399
84MP0003718_maternal_effect0.92714536
85MP0003633_abnormal_nervous_system0.92603350
86MP0005646_abnormal_pituitary_gland0.90173199
87MP0005075_abnormal_melanosome_morpholog0.88765125
88MP0003634_abnormal_glial_cell0.88268731
89MP0001929_abnormal_gametogenesis0.87596264
90MP0005645_abnormal_hypothalamus_physiol0.86470717
91MP0002152_abnormal_brain_morphology0.85321772
92MP0000751_myopathy0.85052952
93MP0000230_abnormal_systemic_arterial0.82153194
94MP0000013_abnormal_adipose_tissue0.80759387
95MP0004142_abnormal_muscle_tone0.80500924
96MP0002928_abnormal_bile_duct0.80287921
97MP0004036_abnormal_muscle_relaxation0.79283442
98MP0003283_abnormal_digestive_organ0.78230559
99MP0003950_abnormal_plasma_membrane0.77551605
100MP0000538_abnormal_urinary_bladder0.76918188
101MP0001664_abnormal_digestion0.76525780
102MP0005174_abnormal_tail_pigmentation0.75607228
103MP0008961_abnormal_basal_metabolism0.74862662
104MP0004043_abnormal_pH_regulation0.74862357
105MP0009780_abnormal_chondrocyte_physiolo0.74789288
106MP0001905_abnormal_dopamine_level0.74550073
107MP0003631_nervous_system_phenotype0.73038669
108MP0002161_abnormal_fertility/fecundity0.72883532
109MP0000653_abnormal_sex_gland0.72871575
110MP0002234_abnormal_pharynx_morphology0.72038161
111MP0003045_fibrosis0.71651350
112MP0005647_abnormal_sex_gland0.70569440
113MP0002069_abnormal_eating/drinking_beha0.70551693
114MP0004085_abnormal_heartbeat0.69745793
115MP0008872_abnormal_physiological_respon0.69401738
116MP0003183_abnormal_peptide_metabolism0.69295915
117MP0004215_abnormal_myocardial_fiber0.69212591
118MP0001188_hyperpigmentation0.69164760
119MP0003137_abnormal_impulse_conducting0.68651091
120MP0004133_heterotaxia0.67080587
121MP0002210_abnormal_sex_determination0.67018630
122MP0005623_abnormal_meninges_morphology0.66562584
123MP0000026_abnormal_inner_ear0.65987381
124MP0003646_muscle_fatigue0.63689680
125MP0001963_abnormal_hearing_physiology0.61778834
126MP0004742_abnormal_vestibular_system0.61414388
127MP0002127_abnormal_cardiovascular_syste0.60317454
128MP0004885_abnormal_endolymph0.59077574

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.29894282
2Abnormal rod and cone electroretinograms (HP:0008323)6.09420534
3Bony spicule pigmentary retinopathy (HP:0007737)5.41895333
4Abnormality of macular pigmentation (HP:0008002)5.33355420
5Severe visual impairment (HP:0001141)5.12382774
6Absent rod-and cone-mediated responses on ERG (HP:0007688)5.03952058
7Genetic anticipation (HP:0003743)4.81598205
8Scotoma (HP:0000575)4.61917263
9Decreased central vision (HP:0007663)4.55358619
10Hyperventilation (HP:0002883)4.44405797
11Myokymia (HP:0002411)4.25002358
12Pendular nystagmus (HP:0012043)3.91122192
13Increased corneal curvature (HP:0100692)3.71238109
14Keratoconus (HP:0000563)3.71238109
15Febrile seizures (HP:0002373)3.65519762
16Epileptic encephalopathy (HP:0200134)3.43624454
17Attenuation of retinal blood vessels (HP:0007843)3.39539094
18Pancreatic cysts (HP:0001737)3.35216048
19Progressive cerebellar ataxia (HP:0002073)3.34495129
20Type II lissencephaly (HP:0007260)3.33466517
21Abolished electroretinogram (ERG) (HP:0000550)3.32516396
22Dyschromatopsia (HP:0007641)3.28002805
23Visual hallucinations (HP:0002367)3.20773702
24Chorioretinal atrophy (HP:0000533)3.18391880
25Action tremor (HP:0002345)3.11432654
26Molar tooth sign on MRI (HP:0002419)3.07974767
27Abnormality of midbrain morphology (HP:0002418)3.07974767
28Type II diabetes mellitus (HP:0005978)3.07591457
29Inability to walk (HP:0002540)3.05037959
30Pheochromocytoma (HP:0002666)3.03424589
31Abnormal gallbladder physiology (HP:0012438)2.95372964
32Cholecystitis (HP:0001082)2.95372964
33Pigmentary retinal degeneration (HP:0001146)2.95148687
34Absent speech (HP:0001344)2.88942114
35True hermaphroditism (HP:0010459)2.84920740
36Chronic hepatic failure (HP:0100626)2.79611161
37Focal seizures (HP:0007359)2.78894273
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76814944
39Absence seizures (HP:0002121)2.72951102
40Ulnar claw (HP:0001178)2.70395785
41Gait imbalance (HP:0002141)2.69395122
42Photophobia (HP:0000613)2.67779233
43Absent/shortened dynein arms (HP:0200106)2.66342914
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.66342914
45Focal motor seizures (HP:0011153)2.65616181
46Protruding tongue (HP:0010808)2.65162004
47Choroideremia (HP:0001139)2.63523062
48Neuroendocrine neoplasm (HP:0100634)2.62537518
49Atonic seizures (HP:0010819)2.62030359
50Intestinal atresia (HP:0011100)2.61728886
51Cerebellar dysplasia (HP:0007033)2.61231108
52Broad-based gait (HP:0002136)2.60658209
53Abnormality of the renal medulla (HP:0100957)2.54305142
54Congenital primary aphakia (HP:0007707)2.53164913
55Medial flaring of the eyebrow (HP:0010747)2.51746034
56Cystic liver disease (HP:0006706)2.51165454
57Thyroiditis (HP:0100646)2.48037445
58Abnormality of the lower motor neuron (HP:0002366)2.46731859
59Retinitis pigmentosa (HP:0000510)2.43103345
60Abnormality of the renal cortex (HP:0011035)2.41480765
61Supranuclear gaze palsy (HP:0000605)2.40566748
62Constricted visual fields (HP:0001133)2.39994710
63Progressive inability to walk (HP:0002505)2.38590626
64Congenital sensorineural hearing impairment (HP:0008527)2.37846308
65Ankle clonus (HP:0011448)2.35465322
66Postural instability (HP:0002172)2.34906240
67Cone-rod dystrophy (HP:0000548)2.34859655
68Genital tract atresia (HP:0001827)2.34641205
69Depression (HP:0000716)2.32836773
70Tubulointerstitial nephritis (HP:0001970)2.32252620
71Hypercortisolism (HP:0001578)2.32121366
72Hypoventilation (HP:0002791)2.30802768
73Dialeptic seizures (HP:0011146)2.29616079
74Vaginal atresia (HP:0000148)2.27717778
75Hypothermia (HP:0002045)2.26430126
76Nephrogenic diabetes insipidus (HP:0009806)2.25797874
77Clumsiness (HP:0002312)2.25209892
78Macular degeneration (HP:0000608)2.23851008
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.20458635
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19682155
81Lissencephaly (HP:0001339)2.18442325
82Posterior subcapsular cataract (HP:0007787)2.17803730
83Truncal ataxia (HP:0002078)2.16133302
84Amblyopia (HP:0000646)2.14006260
85Impaired smooth pursuit (HP:0007772)2.13547450
86Neoplasm of the heart (HP:0100544)2.09373607
87Abnormal drinking behavior (HP:0030082)2.07520665
88Polydipsia (HP:0001959)2.07520665
89Generalized tonic-clonic seizures (HP:0002069)2.06912830
90Hypsarrhythmia (HP:0002521)2.03749646
91Failure to thrive in infancy (HP:0001531)2.03154545
92Congenital stationary night blindness (HP:0007642)10.1005705
93Menstrual irregularities (HP:0000858)1.98852802
94Abnormality of the labia minora (HP:0012880)1.94668488
95Abnormal respiratory motile cilium physiology (HP:0012261)1.93604357
96Rhinitis (HP:0012384)1.93454623
97Aplasia/Hypoplasia of the fovea (HP:0008060)1.91829893
98Hypoplasia of the fovea (HP:0007750)1.91829893
99Hemiparesis (HP:0001269)1.91798505
100Impaired pain sensation (HP:0007328)1.88872202
101Abnormality of pain sensation (HP:0010832)1.88872202
102Abnormality of calcium-phosphate metabolism (HP:0100530)1.87677096
103Retinal dysplasia (HP:0007973)1.87356992
104Amyotrophic lateral sclerosis (HP:0007354)1.87093546
105Septo-optic dysplasia (HP:0100842)1.86480986
106Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86042571
107Abnormality of the fovea (HP:0000493)1.84130969
108Short foot (HP:0001773)1.83020884
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.82206976
110Fair hair (HP:0002286)1.82063565
111Poor coordination (HP:0002370)1.80919396
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80821907
113Hypoplasia of the brainstem (HP:0002365)1.80821907
114Dysdiadochokinesis (HP:0002075)1.79636782
115Tented upper lip vermilion (HP:0010804)1.79298989
116Agitation (HP:0000713)1.79293250
117Hemiplegia (HP:0002301)1.79045440
118Tubulointerstitial abnormality (HP:0001969)1.78253947
119Chronic bronchitis (HP:0004469)1.78093302
120Severe combined immunodeficiency (HP:0004430)1.78039210
121Abnormal respiratory motile cilium morphology (HP:0005938)1.77825381
122Abnormal respiratory epithelium morphology (HP:0012253)1.77825381
123Urinary bladder sphincter dysfunction (HP:0002839)1.77333411
124Aplasia/Hypoplasia of the lens (HP:0008063)1.77155738
125Diplopia (HP:0000651)1.75963966
126Abnormality of binocular vision (HP:0011514)1.75963966
127Occipital encephalocele (HP:0002085)1.75706695
128Abnormality of ocular smooth pursuit (HP:0000617)1.75449132
129Poor eye contact (HP:0000817)1.74734147
130Renal cortical cysts (HP:0000803)1.74397389
131EEG with generalized epileptiform discharges (HP:0011198)1.74123444
132Bile duct proliferation (HP:0001408)1.73473554
133Abnormal biliary tract physiology (HP:0012439)1.73473554
134Abnormality of dental color (HP:0011073)1.72662223
135Pancreatic fibrosis (HP:0100732)1.72402075
136Intellectual disability, severe (HP:0010864)1.71633801
137Specific learning disability (HP:0001328)1.71388488
138Highly arched eyebrow (HP:0002553)1.71321649
139Aplasia/Hypoplasia of the macula (HP:0008059)1.71124995
140Postaxial foot polydactyly (HP:0001830)1.71117523
141Dysautonomia (HP:0002459)1.70456968
142Ventricular fibrillation (HP:0001663)1.70424759
143Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70228667
144Termporal pattern (HP:0011008)1.69469109
145Insidious onset (HP:0003587)1.69469109
146Widely spaced teeth (HP:0000687)1.69248339
147Epileptiform EEG discharges (HP:0011182)1.68907234
148Hammertoe (HP:0001765)1.68574679
149Impaired vibratory sensation (HP:0002495)1.68335296
150Congenital hepatic fibrosis (HP:0002612)1.67548683
151Nephronophthisis (HP:0000090)1.67139027
152Limb dystonia (HP:0002451)1.66693563
153Thyroid carcinoma (HP:0002890)1.66244637
154Large for gestational age (HP:0001520)1.65836946
155Gaze-evoked nystagmus (HP:0000640)1.65143875
156Aganglionic megacolon (HP:0002251)1.64995735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.95599066
2MAP4K23.26241496
3NTRK13.18532266
4MAP3K93.15400529
5MINK13.08775425
6NTRK33.01147545
7PAK62.95546407
8PRKD32.83204012
9NEK12.78694972
10ADRBK22.69634161
11MAP3K42.66221962
12KSR22.38063634
13MARK12.33008603
14PDK42.06520495
15PDK32.06520495
16NUAK12.05403609
17ZAK2.02155572
18TESK11.90839969
19STK381.88207758
20GRK51.84588675
21LMTK21.83936913
22MAP2K71.81607404
23PHKG11.69402113
24PHKG21.69402113
25TNK21.65754953
26TAOK31.61783002
27TRIM281.50964499
28PINK11.50284293
29GRK11.46909235
30LATS21.44633905
31PLK41.40477317
32PRPF4B1.33994266
33OXSR11.33272043
34CAMKK11.33168623
35SGK2231.28865807
36SGK4941.28865807
37NLK1.27609043
38MAP2K41.26747701
39CSNK1G31.25713687
40RET1.23547794
41CSNK1A1L1.23240173
42EPHA31.22682620
43NTRK21.18666068
44TXK1.18299183
45ARAF1.17976108
46CSNK1G21.16244901
47CDK141.14774733
48ICK1.13854439
49MAP3K21.13810139
50CAMKK21.13178444
51CDK51.09471298
52WNK41.08436970
53PTK2B1.08314275
54CSNK1G11.08229247
55PNCK1.06443100
56MAPK131.06290988
57ACVR1B1.05916790
58PRKCG1.04909280
59MAP2K21.03077616
60DAPK21.02920601
61CASK1.02902400
62MAP3K71.01559564
63WNK11.01304358
64BCR1.01203726
65LIMK11.00738701
66DYRK1A1.00496371
67CDK180.98814962
68CDK150.96067943
69RIPK10.96052793
70UHMK10.92277104
71FER0.92118395
72KSR10.91985325
73MATK0.91894643
74CAMK40.90850864
75LATS10.90500837
76PKN10.87868583
77PDK20.87231570
78BRAF0.84888971
79CDK11A0.84717127
80EIF2AK30.84313310
81SIK20.83603649
82INSRR0.82700384
83CCNB10.81757872
84TAOK10.76114734
85CDK190.73383195
86PIK3CG0.72809470
87PAK30.71777842
88STK38L0.71773438
89FGFR20.70946921
90MAP3K10.70364923
91CAMK10.69732112
92SCYL20.69591219
93MAP2K10.69512367
94ADRBK10.69365724
95MUSK0.69245125
96SGK20.68418718
97SIK30.68100293
98CAMK2A0.67185753
99RPS6KA20.66344132
100MARK20.65679475
101MAPKAPK30.65355904
102PBK0.64237003
103CDK80.63405668
104PLK20.63060845
105TAOK20.62850416
106BMPR1B0.62544588
107MAP3K110.62516634
108MAP3K120.62467639
109PRKD20.60567887
110PRKAA10.59775333
111DYRK20.59103645
112CSNK1D0.57751767
113AKT30.56938506
114PRKCZ0.56784229
115PRKCH0.56741055
116IRAK20.55632691
117BRSK10.55408226
118PRKCQ0.54266882
119CAMK2D0.53495463
120MAPK100.52531371
121CDC42BPA0.52148721
122HIPK20.51909114
123DAPK10.51593004
124PTK20.51526125
125CAMK1G0.49830067
126PRKG10.49317650
127ERBB20.49314390
128EPHA40.47022949
129WNK30.46073568
130STK110.44939264
131NEK60.42724939
132PRKCE0.42638197
133CAMK2B0.41268346
134FES0.41141303
135SGK30.39562771
136DYRK1B0.39192353
137MAPK110.39140130
138RPS6KA30.38622436
139STK390.38250314
140PRKCB0.37372840
141PRKACA0.36324508
142VRK10.35339948
143CDK90.34281380
144CSNK1A10.33973276
145MKNK20.33968488
146MAP4K10.33085204
147IKBKB0.32819885
148PRKAA20.32184291
149TLK10.31019814
150VRK20.30326637

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.15252534
2Synaptic vesicle cycle_Homo sapiens_hsa047214.19974618
3Nicotine addiction_Homo sapiens_hsa050333.06451774
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.84776588
5GABAergic synapse_Homo sapiens_hsa047272.61086467
6Olfactory transduction_Homo sapiens_hsa047402.42282089
7Insulin secretion_Homo sapiens_hsa049112.35567031
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34936400
9Circadian entrainment_Homo sapiens_hsa047132.34242249
10Morphine addiction_Homo sapiens_hsa050322.28210626
11Butanoate metabolism_Homo sapiens_hsa006502.09590371
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07376895
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07314703
14Dopaminergic synapse_Homo sapiens_hsa047281.95706399
15Cholinergic synapse_Homo sapiens_hsa047251.95233978
16Glutamatergic synapse_Homo sapiens_hsa047241.82818384
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81019873
18Taste transduction_Homo sapiens_hsa047421.80169039
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72691120
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71812656
21Collecting duct acid secretion_Homo sapiens_hsa049661.69201314
22Salivary secretion_Homo sapiens_hsa049701.66633075
23ABC transporters_Homo sapiens_hsa020101.66368221
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65940872
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59856116
26Renin secretion_Homo sapiens_hsa049241.58617123
27Amphetamine addiction_Homo sapiens_hsa050311.57973754
28Serotonergic synapse_Homo sapiens_hsa047261.55923784
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55159216
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43412349
31Long-term potentiation_Homo sapiens_hsa047201.42788990
32Cardiac muscle contraction_Homo sapiens_hsa042601.42125952
33Circadian rhythm_Homo sapiens_hsa047101.39504355
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37110205
35Basal transcription factors_Homo sapiens_hsa030221.35572501
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32924918
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32377940
38Oxytocin signaling pathway_Homo sapiens_hsa049211.31755156
39Vibrio cholerae infection_Homo sapiens_hsa051101.26181324
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23500735
41Fructose and mannose metabolism_Homo sapiens_hsa000511.22386262
42Nitrogen metabolism_Homo sapiens_hsa009101.21749330
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.21549094
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.18357408
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17892219
46Type II diabetes mellitus_Homo sapiens_hsa049301.17424640
47Cocaine addiction_Homo sapiens_hsa050301.17092675
48Ether lipid metabolism_Homo sapiens_hsa005651.14260563
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14259926
50Fanconi anemia pathway_Homo sapiens_hsa034601.12852138
51Tryptophan metabolism_Homo sapiens_hsa003801.12722858
52Linoleic acid metabolism_Homo sapiens_hsa005911.10214129
53Calcium signaling pathway_Homo sapiens_hsa040201.09568796
54Oocyte meiosis_Homo sapiens_hsa041141.07351299
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06171725
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05237520
57Gap junction_Homo sapiens_hsa045401.03874770
58Gastric acid secretion_Homo sapiens_hsa049711.03406941
59Long-term depression_Homo sapiens_hsa047300.99933152
60GnRH signaling pathway_Homo sapiens_hsa049120.98658118
61Glucagon signaling pathway_Homo sapiens_hsa049220.89191797
62cAMP signaling pathway_Homo sapiens_hsa040240.87354593
63Fatty acid biosynthesis_Homo sapiens_hsa000610.86421843
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85818026
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.84931344
66Estrogen signaling pathway_Homo sapiens_hsa049150.84708950
67Fatty acid metabolism_Homo sapiens_hsa012120.84216609
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.81261326
69mTOR signaling pathway_Homo sapiens_hsa041500.79788879
70Dorso-ventral axis formation_Homo sapiens_hsa043200.78325174
71Ovarian steroidogenesis_Homo sapiens_hsa049130.75843666
72Selenocompound metabolism_Homo sapiens_hsa004500.75699209
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75543537
74Alcoholism_Homo sapiens_hsa050340.74146428
75Pancreatic secretion_Homo sapiens_hsa049720.72715480
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72644203
77Homologous recombination_Homo sapiens_hsa034400.72531801
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72178947
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71072739
80Thyroid hormone synthesis_Homo sapiens_hsa049180.70222439
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69547608
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69314687
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69183364
84Inositol phosphate metabolism_Homo sapiens_hsa005620.69103323
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65710531
86Dilated cardiomyopathy_Homo sapiens_hsa054140.64902999
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.64396502
88Glioma_Homo sapiens_hsa052140.62581725
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61249118
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.59574629
91Peroxisome_Homo sapiens_hsa041460.58649100
92Propanoate metabolism_Homo sapiens_hsa006400.58455243
93Primary immunodeficiency_Homo sapiens_hsa053400.56490492
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56129725
95Insulin signaling pathway_Homo sapiens_hsa049100.55589509
96Choline metabolism in cancer_Homo sapiens_hsa052310.53375440
97Axon guidance_Homo sapiens_hsa043600.52862369
98Endocytosis_Homo sapiens_hsa041440.52855560
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52541603
100Sphingolipid metabolism_Homo sapiens_hsa006000.52406949
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51778550
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51071997
103ErbB signaling pathway_Homo sapiens_hsa040120.50416419
104Lysine degradation_Homo sapiens_hsa003100.50133452
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.49723495
106Melanogenesis_Homo sapiens_hsa049160.49142089
107Retinol metabolism_Homo sapiens_hsa008300.48852462
108Mineral absorption_Homo sapiens_hsa049780.48818559
109MAPK signaling pathway_Homo sapiens_hsa040100.47401900
110Pyruvate metabolism_Homo sapiens_hsa006200.46876852
111Arachidonic acid metabolism_Homo sapiens_hsa005900.46771026
112VEGF signaling pathway_Homo sapiens_hsa043700.45130931
113Endometrial cancer_Homo sapiens_hsa052130.44957341
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44810256
115Chemical carcinogenesis_Homo sapiens_hsa052040.44216008
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43540689
117Galactose metabolism_Homo sapiens_hsa000520.42763059
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41927617
119Bile secretion_Homo sapiens_hsa049760.41757755
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.41548101
121beta-Alanine metabolism_Homo sapiens_hsa004100.39263686
122Biosynthesis of amino acids_Homo sapiens_hsa012300.38694869
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38664391
124Fatty acid elongation_Homo sapiens_hsa000620.35970983
125AMPK signaling pathway_Homo sapiens_hsa041520.34534936
126Melanoma_Homo sapiens_hsa052180.34418332
127HIF-1 signaling pathway_Homo sapiens_hsa040660.34329254
128RNA degradation_Homo sapiens_hsa030180.33565349
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33295282
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33029940
131Hedgehog signaling pathway_Homo sapiens_hsa043400.32895667
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31534850
133Ras signaling pathway_Homo sapiens_hsa040140.31432877
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31325720
135Regulation of autophagy_Homo sapiens_hsa041400.30942130
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29547909
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29410919
138Glycerolipid metabolism_Homo sapiens_hsa005610.27114445
139Thyroid cancer_Homo sapiens_hsa052160.26503929
140Colorectal cancer_Homo sapiens_hsa052100.25573947
141Huntingtons disease_Homo sapiens_hsa050160.25462366
142Prolactin signaling pathway_Homo sapiens_hsa049170.25165545

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