PCBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.75957826
2nucleobase catabolic process (GO:0046113)4.66867700
3postsynaptic membrane organization (GO:0001941)4.62971845
4cell migration in hindbrain (GO:0021535)4.33045708
5layer formation in cerebral cortex (GO:0021819)4.18613939
6synaptic vesicle maturation (GO:0016188)4.01751537
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97196935
8negative regulation of microtubule polymerization (GO:0031115)3.92216123
9neuromuscular synaptic transmission (GO:0007274)3.76967190
10presynaptic membrane organization (GO:0097090)3.75619710
11auditory behavior (GO:0031223)3.71609002
12peptidyl-arginine omega-N-methylation (GO:0035247)3.67246228
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.63804877
14behavioral response to nicotine (GO:0035095)3.58321700
15response to pheromone (GO:0019236)3.55566324
16presynaptic membrane assembly (GO:0097105)3.53688982
17dendritic spine morphogenesis (GO:0060997)3.51133431
18axonal fasciculation (GO:0007413)3.49741024
19establishment of nucleus localization (GO:0040023)3.46482037
20neuron cell-cell adhesion (GO:0007158)3.45537090
21pre-miRNA processing (GO:0031054)3.35131967
22neurotransmitter-gated ion channel clustering (GO:0072578)3.33382109
23peptidyl-arginine methylation (GO:0018216)3.32173978
24peptidyl-arginine N-methylation (GO:0035246)3.32173978
25regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26722101
26pyrimidine nucleobase catabolic process (GO:0006208)3.24291480
27negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23057405
28locomotory exploration behavior (GO:0035641)3.20790467
29ganglion development (GO:0061548)3.19164934
30positive regulation of synapse maturation (GO:0090129)3.17873009
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16500166
32neuron recognition (GO:0008038)3.13840745
33cell communication by electrical coupling (GO:0010644)3.05806100
34histone arginine methylation (GO:0034969)3.04255915
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03249438
36establishment of mitochondrion localization (GO:0051654)3.01920588
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.01069866
38synaptic vesicle endocytosis (GO:0048488)2.99942628
39synapse assembly (GO:0007416)2.99611733
40glutamate secretion (GO:0014047)2.97921271
41synaptic vesicle exocytosis (GO:0016079)2.97218675
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.93228700
43substrate-independent telencephalic tangential migration (GO:0021826)2.93228700
44neuron projection extension (GO:1990138)2.93019711
45regulation of NFAT protein import into nucleus (GO:0051532)2.91505941
46cerebellar granule cell differentiation (GO:0021707)2.91171722
47protein localization to synapse (GO:0035418)2.87923326
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86836892
49mitochondrion transport along microtubule (GO:0047497)2.86836892
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85751692
51dendrite morphogenesis (GO:0048813)2.82396764
52spinal cord association neuron differentiation (GO:0021527)2.81729919
53olfactory bulb development (GO:0021772)2.80822029
54cranial nerve morphogenesis (GO:0021602)2.80392586
55positive regulation of dendritic spine morphogenesis (GO:0061003)2.80384815
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79127456
57positive regulation of synapse assembly (GO:0051965)2.78699116
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.77788531
59response to auditory stimulus (GO:0010996)2.77785663
60cell-cell junction maintenance (GO:0045217)2.76317834
61cerebellar Purkinje cell differentiation (GO:0021702)2.72798433
62mechanosensory behavior (GO:0007638)2.72056208
63transmission of nerve impulse (GO:0019226)2.71622505
64regulation of synaptic vesicle exocytosis (GO:2000300)2.71172621
65regulation of respiratory system process (GO:0044065)2.70704939
66central nervous system projection neuron axonogenesis (GO:0021952)2.70152310
67cellular potassium ion homeostasis (GO:0030007)2.69190505
68cerebellar Purkinje cell layer development (GO:0021680)2.68028600
69neuromuscular process controlling balance (GO:0050885)2.66871894
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65606180
71polarized epithelial cell differentiation (GO:0030859)2.64245825
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64208357
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64021653
74regulation of synapse maturation (GO:0090128)2.63851690
75negative regulation of axon extension involved in axon guidance (GO:0048843)2.63546345
76cerebral cortex neuron differentiation (GO:0021895)2.63442435
77apical protein localization (GO:0045176)2.62588090
78neuronal stem cell maintenance (GO:0097150)2.62525898
79central nervous system myelination (GO:0022010)2.62383607
80axon ensheathment in central nervous system (GO:0032291)2.62383607
81sodium ion export (GO:0071436)2.61804347
82neuronal ion channel clustering (GO:0045161)2.60821305
83adult walking behavior (GO:0007628)2.60183871
84negative regulation of catenin import into nucleus (GO:0035414)2.59919858
85synapse organization (GO:0050808)2.59547458
86ionotropic glutamate receptor signaling pathway (GO:0035235)2.58039056
87negative regulation of axon guidance (GO:1902668)2.55929479
88cerebellum development (GO:0021549)2.55771688
89ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.53731691
90neurofilament cytoskeleton organization (GO:0060052)2.53008218
91cell junction maintenance (GO:0034331)2.52840634
92positive regulation of dendritic spine development (GO:0060999)2.52497637
93regulation of posttranscriptional gene silencing (GO:0060147)2.52495322
94regulation of gene silencing by miRNA (GO:0060964)2.52495322
95regulation of gene silencing by RNA (GO:0060966)2.52495322
96regulation of axonogenesis (GO:0050770)2.52202975
97synaptic transmission, glutamatergic (GO:0035249)2.51858176
98positive regulation of membrane potential (GO:0045838)2.51721842
99vocalization behavior (GO:0071625)2.51484992
100spinal cord development (GO:0021510)2.51294957
101dendritic spine organization (GO:0097061)2.50931438
102neuroblast proliferation (GO:0007405)2.49606649
103cerebral cortex radially oriented cell migration (GO:0021799)2.49459251
104axon extension involved in axon guidance (GO:0048846)2.48483378
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.48483378
106establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47693915
107cell differentiation in hindbrain (GO:0021533)2.46758780
108regulation of synapse structural plasticity (GO:0051823)2.45976324
109positive regulation of gastrulation (GO:2000543)2.45851636
110negative regulation of axonogenesis (GO:0050771)2.45601626
111plasma membrane repair (GO:0001778)2.44599318
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.43684427
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42600618
114membrane hyperpolarization (GO:0060081)2.41946729
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.41188158
116acidic amino acid transport (GO:0015800)2.40855659
117establishment of tissue polarity (GO:0007164)2.40573510
118establishment of planar polarity (GO:0001736)2.40573510
119negative regulation of cell size (GO:0045792)2.40315482
120innervation (GO:0060384)2.39751513
121negative regulation of axon extension (GO:0030517)2.39615698
122dendrite development (GO:0016358)2.39129963
123embryonic foregut morphogenesis (GO:0048617)2.38686618
124exploration behavior (GO:0035640)2.37326192
125peptidyl-lysine dimethylation (GO:0018027)2.37117814
126regulation of neuronal synaptic plasticity (GO:0048168)2.36146005
127neurotransmitter secretion (GO:0007269)2.34732050
128protein-DNA complex disassembly (GO:0032986)2.34471982
129nucleosome disassembly (GO:0006337)2.34471982
130mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.31491217
131axon extension (GO:0048675)2.30908283
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.30237100
133negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.30174773
134regulation of synaptic vesicle transport (GO:1902803)2.28730549
135negative regulation of organelle assembly (GO:1902116)2.28299949
136ephrin receptor signaling pathway (GO:0048013)2.27921352
137mating behavior (GO:0007617)2.27425421
138nucleus localization (GO:0051647)2.26954170
139regulation of glutamate receptor signaling pathway (GO:1900449)2.25316329
140glial cell proliferation (GO:0014009)2.25204135
141retinal ganglion cell axon guidance (GO:0031290)2.24031827
142hippocampus development (GO:0021766)2.23189405
143Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.23072833
144neuronal action potential propagation (GO:0019227)2.22478292
145cochlea morphogenesis (GO:0090103)2.22216619
146regulation of axon extension involved in axon guidance (GO:0048841)2.21730899
147regulation of axon guidance (GO:1902667)2.21721803
148axon cargo transport (GO:0008088)2.20740518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71448350
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.06881563
3* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.97353454
4* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.68964995
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39277438
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31636141
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29902155
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29902155
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.26307694
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21704015
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21302959
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.17169223
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12914868
14* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.08773438
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.08701401
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.06126640
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06059881
18* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05468581
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02259771
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01362813
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99421015
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95748875
23* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.93071368
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.91341140
25KDM2B_26808549_Chip-Seq_K562_Human1.90422410
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89999824
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.85614738
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85312894
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84726712
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.84659759
31DROSHA_22980978_ChIP-Seq_HELA_Human1.75116074
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74264717
33* RING1B_27294783_Chip-Seq_NPCs_Mouse1.70318639
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64929669
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.63346050
36* RING1B_27294783_Chip-Seq_ESCs_Mouse1.63328867
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62796490
38* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62734957
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60665567
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.60421629
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60405643
42* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59274530
43REST_21632747_ChIP-Seq_MESCs_Mouse1.57871765
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57030523
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56665311
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54475889
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49299118
48* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48435694
49* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46741627
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45054782
51KDM2B_26808549_Chip-Seq_DND41_Human1.44900398
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43634309
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43332905
54RNF2_27304074_Chip-Seq_NSC_Mouse1.39278422
55LXR_22292898_ChIP-Seq_THP-1_Human1.38674428
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38254877
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36931748
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36697226
59CTCF_27219007_Chip-Seq_Bcells_Human1.32522221
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28514987
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27080726
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25240775
63CREB1_26743006_Chip-Seq_LNCaP_Human1.24187909
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23452956
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22758228
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.22448993
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20088587
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19866170
69* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19430621
70* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19397510
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18692057
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18396341
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.18392355
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17446150
75ZNF263_19887448_ChIP-Seq_K562_Human1.16177293
76GBX2_23144817_ChIP-Seq_PC3_Human1.16031324
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12201768
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11429620
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10335493
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09848616
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09403245
82POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08494155
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.08293014
84* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.05065444
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03869521
86* P68_20966046_ChIP-Seq_HELA_Human1.03117386
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02821704
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.02482657
89ZNF274_21170338_ChIP-Seq_K562_Hela1.02088466
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.02014518
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.01312603
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01206621
93* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99282326
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99209739
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98951252
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98750729
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98552566
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98112042
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97857042
100* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97788445
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95951957
102TRIM28_21343339_ChIP-Seq_HEK293_Human0.95217403
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94786688
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94272704
105* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93614224
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.93328399
107* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93159077
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.92283070
109* SMC4_20622854_ChIP-Seq_HELA_Human0.92196120
110TP53_22127205_ChIP-Seq_IMR90_Human0.90926313
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90155020
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89861391
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88506197
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88445344
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88392768
116* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88281329
117AR_19668381_ChIP-Seq_PC3_Human0.87078198
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86499073
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85983646
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85653638
121OCT4_19829295_ChIP-Seq_ESCs_Human0.85529349
122NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85229182
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85030407
124MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82049474
125IGF1R_20145208_ChIP-Seq_DFB_Human0.78910786
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78679625
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77828794
128AR_21572438_ChIP-Seq_LNCaP_Human0.74558283
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74299878
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.73110684
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.72198250
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71900802
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.71610734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.98119424
2MP0002822_catalepsy3.93195000
3MP0010030_abnormal_orbit_morphology3.28749060
4MP0004859_abnormal_synaptic_plasticity3.25553171
5MP0004270_analgesia2.39850952
6MP0000778_abnormal_nervous_system2.34527430
7MP0003283_abnormal_digestive_organ2.22133820
8MP0000537_abnormal_urethra_morphology2.20205906
9MP0001529_abnormal_vocalization2.11074170
10MP0003880_abnormal_central_pattern1.98670599
11MP0003122_maternal_imprinting1.92797913
12MP0003635_abnormal_synaptic_transmissio1.90850708
13MP0004858_abnormal_nervous_system1.90185227
14MP0005423_abnormal_somatic_nervous1.90133601
15MP0006072_abnormal_retinal_apoptosis1.86122985
16MP0005623_abnormal_meninges_morphology1.84994611
17MP0003787_abnormal_imprinting1.79106869
18MP0004133_heterotaxia1.74068670
19MP0005394_taste/olfaction_phenotype1.71239573
20MP0005499_abnormal_olfactory_system1.71239573
21MP0008789_abnormal_olfactory_epithelium1.71188045
22MP0002184_abnormal_innervation1.70092751
23MP0004233_abnormal_muscle_weight1.68082403
24MP0005551_abnormal_eye_electrophysiolog1.67123477
25MP0000955_abnormal_spinal_cord1.66144031
26MP0003119_abnormal_digestive_system1.62268001
27MP0003890_abnormal_embryonic-extraembry1.62178576
28MP0003861_abnormal_nervous_system1.59588353
29MP0002638_abnormal_pupillary_reflex1.55434989
30MP0002063_abnormal_learning/memory/cond1.53588405
31MP0002734_abnormal_mechanical_nocicepti1.53286603
32MP0002882_abnormal_neuron_morphology1.50182111
33MP0002234_abnormal_pharynx_morphology1.48654432
34MP0000534_abnormal_ureter_morphology1.46136203
35MP0004811_abnormal_neuron_physiology1.44554566
36MP0005253_abnormal_eye_physiology1.43209975
37MP0004145_abnormal_muscle_electrophysio1.42995545
38MP0000751_myopathy1.42838485
39MP0001188_hyperpigmentation1.36945921
40MP0001968_abnormal_touch/_nociception1.36838932
41MP0002752_abnormal_somatic_nervous1.36722027
42MP0001299_abnormal_eye_distance/1.36451156
43MP0002152_abnormal_brain_morphology1.33294349
44MP0002064_seizures1.30793955
45MP0002751_abnormal_autonomic_nervous1.30787721
46MP0003123_paternal_imprinting1.30283469
47MP0003385_abnormal_body_wall1.30200255
48MP0003942_abnormal_urinary_system1.29038166
49MP0004885_abnormal_endolymph1.28282313
50MP0003121_genomic_imprinting1.27987039
51MP0000049_abnormal_middle_ear1.25983124
52MP0002272_abnormal_nervous_system1.24523408
53MP0000733_abnormal_muscle_development1.24466030
54MP0001502_abnormal_circadian_rhythm1.24000052
55MP0009046_muscle_twitch1.21000800
56MP0005187_abnormal_penis_morphology1.20857503
57MP0003011_delayed_dark_adaptation1.19444386
58MP0000428_abnormal_craniofacial_morphol1.16870814
59MP0009745_abnormal_behavioral_response1.16124667
60MP0001486_abnormal_startle_reflex1.15615938
61MP0009053_abnormal_anal_canal1.13644684
62MP0002909_abnormal_adrenal_gland1.13568430
63MP0003115_abnormal_respiratory_system1.12925731
64MP0003705_abnormal_hypodermis_morpholog1.12671137
65MP0003137_abnormal_impulse_conducting1.12336922
66MP0002733_abnormal_thermal_nociception1.11157177
67MP0003879_abnormal_hair_cell1.10541405
68MP0006276_abnormal_autonomic_nervous1.10179203
69MP0001905_abnormal_dopamine_level1.09967125
70MP0002932_abnormal_joint_morphology1.08463162
71MP0002089_abnormal_postnatal_growth/wei1.06306390
72MP0005195_abnormal_posterior_eye1.06186608
73MP0002084_abnormal_developmental_patter1.05427064
74MP0000749_muscle_degeneration1.04123199
75MP0005391_vision/eye_phenotype1.04064156
76MP0002557_abnormal_social/conspecific_i1.03915475
77MP0005386_behavior/neurological_phenoty1.03532100
78MP0004924_abnormal_behavior1.03532100
79MP0002085_abnormal_embryonic_tissue1.01646179
80MP0002067_abnormal_sensory_capabilities1.01398773
81MP0000026_abnormal_inner_ear1.01031573
82MP0008569_lethality_at_weaning1.01001312
83MP0002572_abnormal_emotion/affect_behav1.00792807
84MP0003937_abnormal_limbs/digits/tail_de1.00357629
85MP0003315_abnormal_perineum_morphology0.99591005
86MP0005248_abnormal_Harderian_gland0.99517955
87MP0001293_anophthalmia0.98931108
88MP0005257_abnormal_intraocular_pressure0.98331771
89MP0002735_abnormal_chemical_nociception0.97865576
90MP0002697_abnormal_eye_size0.97253198
91MP0002233_abnormal_nose_morphology0.96819699
92MP0003938_abnormal_ear_development0.96767265
93MP0002249_abnormal_larynx_morphology0.96758772
94MP0003755_abnormal_palate_morphology0.96333847
95MP0001849_ear_inflammation0.96321906
96MP0001440_abnormal_grooming_behavior0.96036415
97MP0002116_abnormal_craniofacial_bone0.95302760
98MP0003634_abnormal_glial_cell0.95040182
99MP0002066_abnormal_motor_capabilities/c0.94712247
100MP0002081_perinatal_lethality0.94342469
101MP0000631_abnormal_neuroendocrine_gland0.94257207
102MP0001346_abnormal_lacrimal_gland0.94140696
103MP0003935_abnormal_craniofacial_develop0.91373970
104MP0003329_amyloid_beta_deposits0.90909114
105MP0008961_abnormal_basal_metabolism0.90266681
106MP0001984_abnormal_olfaction0.89664868
107MP0006292_abnormal_olfactory_placode0.89354782
108MP0000747_muscle_weakness0.88838552
109MP0001970_abnormal_pain_threshold0.87854191
110MP0002736_abnormal_nociception_after0.86547873
111MP0001348_abnormal_lacrimal_gland0.85143106
112MP0000759_abnormal_skeletal_muscle0.84759639
113MP0003633_abnormal_nervous_system0.83810196
114MP0005409_darkened_coat_color0.83406336
115MP0004197_abnormal_fetal_growth/weight/0.82921674
116MP0004142_abnormal_muscle_tone0.81928124
117MP0001730_embryonic_growth_arrest0.81548043
118MP0000566_synostosis0.81358883
119MP0002069_abnormal_eating/drinking_beha0.81215460
120MP0001963_abnormal_hearing_physiology0.81083544
121MP0010386_abnormal_urinary_bladder0.81077574
122MP0002282_abnormal_trachea_morphology0.80406020
123MP0004742_abnormal_vestibular_system0.80353556
124MP0001943_abnormal_respiration0.76039804
125MP0002229_neurodegeneration0.75260052
126MP0003631_nervous_system_phenotype0.74454925
127MP0000750_abnormal_muscle_regeneration0.70539408

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.25098070
2Renal duplication (HP:0000075)3.12547003
3Insomnia (HP:0100785)3.00084816
4Hyperacusis (HP:0010780)2.98894858
5Fetal akinesia sequence (HP:0001989)2.73762379
6Peripheral hypomyelination (HP:0007182)2.69789371
7Cortical dysplasia (HP:0002539)2.68683370
8Overriding aorta (HP:0002623)2.67500196
9Central scotoma (HP:0000603)2.61368213
10Polyphagia (HP:0002591)2.59841736
11Abnormality of the lower motor neuron (HP:0002366)2.57788509
12Elfin facies (HP:0004428)2.56103040
13Shallow orbits (HP:0000586)2.54230243
14Pointed chin (HP:0000307)2.50355208
15Termporal pattern (HP:0011008)2.47909469
16Insidious onset (HP:0003587)2.47909469
17Anomalous pulmonary venous return (HP:0010772)2.45713051
18Limb dystonia (HP:0002451)2.43184439
19Renovascular hypertension (HP:0100817)2.38128922
20Type 1 muscle fiber predominance (HP:0003803)2.38024945
21Action tremor (HP:0002345)2.36491547
22Ankle clonus (HP:0011448)2.34936142
23Pendular nystagmus (HP:0012043)2.33269332
24Focal motor seizures (HP:0011153)2.29406979
25Flat cornea (HP:0007720)2.29231101
26Scotoma (HP:0000575)2.26334128
27Abnormality of the intervertebral disk (HP:0005108)2.24428002
28Congenital stationary night blindness (HP:0007642)2.23463115
29Chorioretinal atrophy (HP:0000533)2.22647856
30Drooling (HP:0002307)2.22438401
31Supranuclear gaze palsy (HP:0000605)2.21605859
32Neoplasm of the heart (HP:0100544)2.20744075
33Epileptic encephalopathy (HP:0200134)2.20519401
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20401835
35Short 4th metacarpal (HP:0010044)2.20401835
36Lower limb amyotrophy (HP:0007210)2.19980877
37Abnormal eating behavior (HP:0100738)2.19313246
38Torticollis (HP:0000473)2.16275965
39Abnormality of the pulmonary veins (HP:0011718)2.15681429
40Sleep apnea (HP:0010535)2.15063206
41Bony spicule pigmentary retinopathy (HP:0007737)2.12552223
42Myotonia (HP:0002486)2.11445707
43Bowel diverticulosis (HP:0005222)2.09255342
44Retinal dysplasia (HP:0007973)2.04657860
45Astrocytoma (HP:0009592)2.03130578
46Abnormality of the astrocytes (HP:0100707)2.03130578
47Shoulder girdle muscle weakness (HP:0003547)2.02193588
48Bladder diverticulum (HP:0000015)2.01250384
49Anosmia (HP:0000458)2.01132201
50Exercise-induced muscle cramps (HP:0003710)1.99748904
51Cerebral hypomyelination (HP:0006808)1.99369901
52Excessive salivation (HP:0003781)1.97963399
53Rib fusion (HP:0000902)1.96033459
54Myopathic facies (HP:0002058)1.94362123
55Focal seizures (HP:0007359)1.94167427
56Megalencephaly (HP:0001355)1.93874987
57Obstructive sleep apnea (HP:0002870)1.93825821
58Akinesia (HP:0002304)1.93753880
59Megalocornea (HP:0000485)1.93014942
60Abnormality of the diencephalon (HP:0010662)1.90351238
61Vitreoretinal degeneration (HP:0000655)1.90334692
62Atonic seizures (HP:0010819)1.89877014
63Exotropia (HP:0000577)1.87018411
64Congenital malformation of the right heart (HP:0011723)1.86800581
65Double outlet right ventricle (HP:0001719)1.86800581
66Ependymoma (HP:0002888)1.86727699
67Hypoplasia of the brainstem (HP:0002365)1.85559024
68Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85559024
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85280123
70Urinary urgency (HP:0000012)1.85125515
71Distal upper limb amyotrophy (HP:0007149)1.85034747
72Upper limb amyotrophy (HP:0009129)1.85034747
73Lower limb muscle weakness (HP:0007340)1.84869108
74Aqueductal stenosis (HP:0002410)1.83790144
75Muscle fiber inclusion bodies (HP:0100299)1.83735604
76Gait imbalance (HP:0002141)1.83390018
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80796181
78Abnormality of the labia minora (HP:0012880)1.80401508
79Increased nuchal translucency (HP:0010880)1.80295208
80Trigonocephaly (HP:0000243)1.79402517
81Septo-optic dysplasia (HP:0100842)1.79216682
82Posterior subcapsular cataract (HP:0007787)1.77747221
83Turricephaly (HP:0000262)1.77207062
84Difficulty climbing stairs (HP:0003551)1.76120860
85Hammertoe (HP:0001765)1.74722883
86Anterior segment dysgenesis (HP:0007700)1.74652966
87Spastic gait (HP:0002064)1.73870650
88Febrile seizures (HP:0002373)1.73748155
89Poor suck (HP:0002033)1.73649824
90Mildly elevated creatine phosphokinase (HP:0008180)1.72493404
91Abnormality of the 4th metacarpal (HP:0010012)1.72428399
92Urinary bladder sphincter dysfunction (HP:0002839)1.71063582
93Round ear (HP:0100830)1.70405295
94Abnormality of the aortic arch (HP:0012303)1.70389703
95Abnormal rod and cone electroretinograms (HP:0008323)1.70057397
96Abnormality of the corticospinal tract (HP:0002492)1.69038493
97Nemaline bodies (HP:0003798)1.68695887
98Difficulty running (HP:0009046)1.68676649
99Anophthalmia (HP:0000528)1.68046185
100Spina bifida occulta (HP:0003298)1.68032049
101Progressive cerebellar ataxia (HP:0002073)1.67544707
102Pelvic girdle muscle weakness (HP:0003749)1.67290712
103Ulnar claw (HP:0001178)1.66074484
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65832150
105Hypoplasia of the corpus callosum (HP:0002079)1.65802532
106Visual hallucinations (HP:0002367)1.64787970
107Abnormality of abdominal situs (HP:0011620)1.64005841
108Abdominal situs inversus (HP:0003363)1.64005841
109High anterior hairline (HP:0009890)1.63976928
110Precocious puberty (HP:0000826)1.63940038
111Focal dystonia (HP:0004373)1.63920184
112Scapular winging (HP:0003691)1.62929113
113Spastic tetraplegia (HP:0002510)1.62901080
114Abnormality of the foot musculature (HP:0001436)1.62849028
115Amblyopia (HP:0000646)1.62765639
116Failure to thrive in infancy (HP:0001531)1.62762504
117Sacral dimple (HP:0000960)1.62677752
118Abnormality of macular pigmentation (HP:0008002)1.62102934
119Distal lower limb amyotrophy (HP:0008944)1.62026963
120Pachygyria (HP:0001302)1.61793957
121Amyotrophic lateral sclerosis (HP:0007354)1.61595647
122Neurofibrillary tangles (HP:0002185)1.61151629
123Incomplete penetrance (HP:0003829)1.61126483
124Hand muscle atrophy (HP:0009130)1.61081910
125Intention tremor (HP:0002080)1.60195743
126Down-sloping shoulders (HP:0200021)1.60101884
127Abnormality of the hip-girdle musculature (HP:0001445)1.59784199
128Abnormality of the musculature of the pelvis (HP:0001469)1.59784199
129Annular pancreas (HP:0001734)1.59542584
130Intestinal atresia (HP:0011100)1.59199143
131Adducted thumb (HP:0001181)1.58336727
132Rimmed vacuoles (HP:0003805)1.57938911
133Calcaneovalgus deformity (HP:0001848)1.57055400
134Specific learning disability (HP:0001328)1.56777594
135Spinal rigidity (HP:0003306)1.56766863
136Epileptiform EEG discharges (HP:0011182)1.55658997
137Depression (HP:0000716)1.55261950
138Abnormal number of incisors (HP:0011064)1.54685021
139Arnold-Chiari malformation (HP:0002308)1.54511672
140Deviation of the hallux (HP:0010051)1.54339867
141Esophageal atresia (HP:0002032)1.53570235
142Wrist flexion contracture (HP:0001239)1.53500135
143Deep palmar crease (HP:0006191)1.52954017
144Bronchomalacia (HP:0002780)1.52944119
145Coronal craniosynostosis (HP:0004440)1.52883878
146Hepatoblastoma (HP:0002884)1.52202625
147Hypoventilation (HP:0002791)1.52199312
148Protrusio acetabuli (HP:0003179)1.51530056
149Hallux valgus (HP:0001822)1.51350311
150Foot dorsiflexor weakness (HP:0009027)1.51027083
151Vertebral fusion (HP:0002948)1.50309723
152Impaired vibration sensation in the lower limbs (HP:0002166)1.49402018
153Hemivertebrae (HP:0002937)1.46820010
154Generalized hypotonia (HP:0001290)1.46586058
155Obsessive-compulsive behavior (HP:0000722)1.46156167
156Alacrima (HP:0000522)1.45535043
157Abolished electroretinogram (ERG) (HP:0000550)1.45233712
158Buphthalmos (HP:0000557)1.45171776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.14484866
2PAK62.59261365
3CASK2.58463406
4ICK2.48386205
5LATS22.42835426
6MAP3K92.36044876
7KSR12.27335264
8TYRO32.26668616
9UHMK12.24009592
10EPHB22.11250743
11LIMK12.02407638
12PRKD31.99470522
13MINK11.98869531
14MAP2K71.86940743
15MAP3K101.83808141
16NEK11.76773156
17TRIB31.74219969
18NTRK21.73128447
19KSR21.67167958
20PDGFRA1.62516574
21MAP4K21.59002131
22DDR21.55688772
23FGFR21.54665212
24NTRK31.50748529
25TESK21.50513479
26MAP3K41.45169958
27PHKG21.37948704
28PHKG11.37948704
29CDK181.31622882
30CDK141.31303361
31PKN21.31246562
32CDK151.30503165
33DYRK21.29516641
34NTRK11.27559622
35PNCK1.22501273
36EPHA31.22056142
37PAK31.21215969
38CDK11A1.19234145
39BCR1.19075425
40PINK11.16498783
41ALK1.13291673
42OBSCN1.11606043
43FGFR11.10368082
44ERBB21.06929339
45DYRK31.04547579
46ROCK21.02883649
47RPS6KA21.01124230
48CAMKK10.95432376
49CDK190.95030441
50TTN0.94545260
51EPHA40.94391944
52TESK10.93474636
53CDC42BPA0.92173425
54CDK50.91729926
55RET0.89330553
56EEF2K0.85980204
57SIK20.85343024
58DAPK20.85268794
59IRAK20.84764306
60CAMK2B0.83323665
61CAMK1G0.81808956
62CAMK10.81585273
63CDK120.81070097
64LMTK20.77873067
65PTK20.76706679
66DYRK1B0.76453046
67BRSK10.76254976
68ARAF0.75914895
69CAMK2G0.75790518
70MTOR0.75721777
71BMX0.75097730
72EPHB10.74458026
73PAK40.74420117
74BUB10.73394667
75STK380.72903130
76CDC70.72673275
77ILK0.72428208
78RIPK10.72379959
79PLK20.72360579
80MAP2K40.71271391
81CAMK40.69119721
82TRIM280.68572808
83MARK20.67904096
84PRKAA10.67410253
85MAP3K60.67284908
86ROCK10.66485009
87SGK2230.66063706
88SGK4940.66063706
89CSNK1G30.65074698
90MAPK130.63962765
91PRPF4B0.63716553
92CSNK1E0.63517606
93BRD40.62830341
94CAMK2A0.62755095
95DAPK30.62164283
96PRKD20.61851781
97PAK20.61419807
98CSNK1G20.61308654
99ERBB30.60864960
100PRKCH0.60838816
101CSNK1A1L0.60684777
102CSNK1G10.60433792
103SGK20.60140282
104PRKCZ0.59216168
105MKNK10.57802473
106PTK60.56387223
107SCYL20.56364848
108MAP3K70.54975615
109DMPK0.54755235
110SGK30.54432289
111STK110.53795013
112MAP3K110.53315857
113FER0.53277708
114AURKA0.53115281
115MAPK150.51533990
116WNK10.50784549
117DYRK1A0.50675419
118MAPK90.49790516
119PASK0.49505069
120AKT20.49214961
121MAPK100.48428509
122PRKCG0.48259322
123CAMK2D0.47490885
124PAK10.46706358
125PRKD10.46165486
126MOS0.45589444
127PKN10.44840569
128SIK30.44615079
129MUSK0.44400076
130NEK20.42335732
131CDK10.41766005
132BCKDK0.41557177
133MAPK80.34463499

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.74266609
2Synaptic vesicle cycle_Homo sapiens_hsa047212.36479366
3Basal cell carcinoma_Homo sapiens_hsa052172.22053803
4Hedgehog signaling pathway_Homo sapiens_hsa043402.14660897
5Axon guidance_Homo sapiens_hsa043602.11037049
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03484612
7Hippo signaling pathway_Homo sapiens_hsa043901.95592074
8GABAergic synapse_Homo sapiens_hsa047271.78940781
9Nicotine addiction_Homo sapiens_hsa050331.72824048
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68644750
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66483122
12Gap junction_Homo sapiens_hsa045401.65260828
13Circadian entrainment_Homo sapiens_hsa047131.63403313
14Glutamatergic synapse_Homo sapiens_hsa047241.63305003
15Dopaminergic synapse_Homo sapiens_hsa047281.60433760
16Notch signaling pathway_Homo sapiens_hsa043301.60191446
17Melanogenesis_Homo sapiens_hsa049161.50806114
18Oocyte meiosis_Homo sapiens_hsa041141.48118317
19Olfactory transduction_Homo sapiens_hsa047401.46769679
20Cholinergic synapse_Homo sapiens_hsa047251.42247412
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42105540
22Long-term potentiation_Homo sapiens_hsa047201.41387102
23Glioma_Homo sapiens_hsa052141.39224471
24Wnt signaling pathway_Homo sapiens_hsa043101.32735873
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31042587
26Tight junction_Homo sapiens_hsa045301.30782659
27mRNA surveillance pathway_Homo sapiens_hsa030151.29395986
28Morphine addiction_Homo sapiens_hsa050321.29221240
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28497115
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25198590
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23547625
32ErbB signaling pathway_Homo sapiens_hsa040121.23277555
33Dilated cardiomyopathy_Homo sapiens_hsa054141.19699031
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.19519469
35mTOR signaling pathway_Homo sapiens_hsa041501.19233938
36Oxytocin signaling pathway_Homo sapiens_hsa049211.19220765
37Endometrial cancer_Homo sapiens_hsa052131.17423602
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16473674
39Renal cell carcinoma_Homo sapiens_hsa052111.15991553
40Colorectal cancer_Homo sapiens_hsa052101.12506129
41Estrogen signaling pathway_Homo sapiens_hsa049151.11398534
42Insulin secretion_Homo sapiens_hsa049111.11265884
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10393150
44GnRH signaling pathway_Homo sapiens_hsa049121.08365343
45Cardiac muscle contraction_Homo sapiens_hsa042601.07270656
46Amphetamine addiction_Homo sapiens_hsa050311.04930700
47Long-term depression_Homo sapiens_hsa047301.04256918
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03939136
49Cocaine addiction_Homo sapiens_hsa050301.03682387
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02449187
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.02155762
52Vibrio cholerae infection_Homo sapiens_hsa051101.01920409
53Bladder cancer_Homo sapiens_hsa052191.01581408
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01083717
55Gastric acid secretion_Homo sapiens_hsa049711.00675358
56Alcoholism_Homo sapiens_hsa050340.99570726
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99439191
58Proteoglycans in cancer_Homo sapiens_hsa052050.99176850
59Spliceosome_Homo sapiens_hsa030400.98952816
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98413453
61VEGF signaling pathway_Homo sapiens_hsa043700.98301275
62Nitrogen metabolism_Homo sapiens_hsa009100.95973026
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95159333
64MicroRNAs in cancer_Homo sapiens_hsa052060.94473644
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93152120
66Arginine and proline metabolism_Homo sapiens_hsa003300.91222800
67Non-small cell lung cancer_Homo sapiens_hsa052230.90170957
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89244921
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87748815
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.86922650
71Chronic myeloid leukemia_Homo sapiens_hsa052200.85644883
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85558289
73Type II diabetes mellitus_Homo sapiens_hsa049300.82052749
74Salivary secretion_Homo sapiens_hsa049700.82040258
75Rap1 signaling pathway_Homo sapiens_hsa040150.81620285
76Melanoma_Homo sapiens_hsa052180.80806966
77Circadian rhythm_Homo sapiens_hsa047100.79915455
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79846182
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76903522
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75954478
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75243611
82Serotonergic synapse_Homo sapiens_hsa047260.74390882
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73349491
84Adherens junction_Homo sapiens_hsa045200.72922399
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71788795
86Renin secretion_Homo sapiens_hsa049240.71231295
87MAPK signaling pathway_Homo sapiens_hsa040100.71193482
88Endocytosis_Homo sapiens_hsa041440.70173958
89Insulin signaling pathway_Homo sapiens_hsa049100.68561003
90Biosynthesis of amino acids_Homo sapiens_hsa012300.67368565
91Focal adhesion_Homo sapiens_hsa045100.67263964
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66669132
93Taste transduction_Homo sapiens_hsa047420.66630535
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66124824
95RNA transport_Homo sapiens_hsa030130.65608037
96Bile secretion_Homo sapiens_hsa049760.64359804
97cAMP signaling pathway_Homo sapiens_hsa040240.64030547
98Steroid biosynthesis_Homo sapiens_hsa001000.63996735
99ECM-receptor interaction_Homo sapiens_hsa045120.63643785
100Pathways in cancer_Homo sapiens_hsa052000.63326416
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62778192
102Choline metabolism in cancer_Homo sapiens_hsa052310.62572970
103Dorso-ventral axis formation_Homo sapiens_hsa043200.62066771
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62022278
105Collecting duct acid secretion_Homo sapiens_hsa049660.60594278
106Cell cycle_Homo sapiens_hsa041100.60195909
107TGF-beta signaling pathway_Homo sapiens_hsa043500.59779053
108AMPK signaling pathway_Homo sapiens_hsa041520.58970053
109Ras signaling pathway_Homo sapiens_hsa040140.58484365
110Glucagon signaling pathway_Homo sapiens_hsa049220.58370518
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56909555
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56076361
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55892172
114Sulfur relay system_Homo sapiens_hsa041220.54740892
115Prion diseases_Homo sapiens_hsa050200.54294974
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54265242
117Inositol phosphate metabolism_Homo sapiens_hsa005620.53540456
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.53321669
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53128024
120Calcium signaling pathway_Homo sapiens_hsa040200.53043655
121Thyroid hormone synthesis_Homo sapiens_hsa049180.47215286
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46555520
123Fatty acid metabolism_Homo sapiens_hsa012120.45798952

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