PCCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.60984445
2L-phenylalanine catabolic process (GO:0006559)6.60984445
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.39627617
4L-phenylalanine metabolic process (GO:0006558)6.39627617
5aromatic amino acid family catabolic process (GO:0009074)5.76438477
6lysine catabolic process (GO:0006554)5.68540579
7lysine metabolic process (GO:0006553)5.68540579
8glyoxylate metabolic process (GO:0046487)5.43406614
9cysteine metabolic process (GO:0006534)5.35246938
10sulfur amino acid catabolic process (GO:0000098)5.13612182
11alpha-linolenic acid metabolic process (GO:0036109)5.10739957
12indole-containing compound catabolic process (GO:0042436)5.02358416
13indolalkylamine catabolic process (GO:0046218)5.02358416
14tryptophan catabolic process (GO:0006569)5.02358416
15kynurenine metabolic process (GO:0070189)4.98651209
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90936099
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.89531039
18bile acid biosynthetic process (GO:0006699)4.85278651
19tryptophan metabolic process (GO:0006568)4.73918883
20serine family amino acid catabolic process (GO:0009071)4.67664976
21amino-acid betaine metabolic process (GO:0006577)4.66182070
22homocysteine metabolic process (GO:0050667)4.57128874
23cellular ketone body metabolic process (GO:0046950)4.54211713
24* fatty acid beta-oxidation (GO:0006635)4.47288440
25acetyl-CoA metabolic process (GO:0006084)4.44352738
26valine metabolic process (GO:0006573)4.41918122
27urea metabolic process (GO:0019627)4.41395360
28urea cycle (GO:0000050)4.41395360
29regulation of triglyceride catabolic process (GO:0010896)4.36718158
302-oxoglutarate metabolic process (GO:0006103)4.34560227
31alpha-amino acid catabolic process (GO:1901606)4.30502413
32* short-chain fatty acid metabolic process (GO:0046459)4.30362444
33aspartate family amino acid catabolic process (GO:0009068)4.26379818
34L-serine metabolic process (GO:0006563)4.24938330
35* fatty acid oxidation (GO:0019395)4.23553289
36complement activation, alternative pathway (GO:0006957)4.21383064
37aromatic amino acid family metabolic process (GO:0009072)4.19259983
38drug transmembrane transport (GO:0006855)4.17375690
39bile acid metabolic process (GO:0008206)4.16851527
40* lipid oxidation (GO:0034440)4.15474160
41cellular amino acid catabolic process (GO:0009063)4.15231679
42* fatty acid catabolic process (GO:0009062)4.12591222
43nitrogen cycle metabolic process (GO:0071941)4.11485080
44branched-chain amino acid catabolic process (GO:0009083)4.09782898
45protein carboxylation (GO:0018214)4.06802797
46peptidyl-glutamic acid carboxylation (GO:0017187)4.06802797
47high-density lipoprotein particle remodeling (GO:0034375)4.01949986
48cellular modified amino acid catabolic process (GO:0042219)4.00893234
49branched-chain amino acid metabolic process (GO:0009081)3.99232900
50acylglycerol homeostasis (GO:0055090)3.97627011
51triglyceride homeostasis (GO:0070328)3.97627011
52tyrosine metabolic process (GO:0006570)3.96427873
53* monocarboxylic acid catabolic process (GO:0072329)3.95964319
54ethanol oxidation (GO:0006069)3.93735174
55glutamate metabolic process (GO:0006536)3.93577212
56coenzyme catabolic process (GO:0009109)3.93520701
57regulation of protein activation cascade (GO:2000257)3.93446864
58ketone body metabolic process (GO:1902224)3.92429124
59negative regulation of fibrinolysis (GO:0051918)3.89637245
60* carboxylic acid catabolic process (GO:0046395)3.87301542
61* organic acid catabolic process (GO:0016054)3.87301542
62fatty acid transmembrane transport (GO:1902001)3.84746460
63carnitine metabolic process (GO:0009437)3.83827914
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.82098225
65drug catabolic process (GO:0042737)3.80951647
66serine family amino acid metabolic process (GO:0009069)3.78821659
67urate metabolic process (GO:0046415)3.78491599
68regulation of fibrinolysis (GO:0051917)3.72320214
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71276118
70regulation of complement activation (GO:0030449)3.70942657
71tricarboxylic acid metabolic process (GO:0072350)3.64213918
72carnitine shuttle (GO:0006853)3.63018575
73plasma lipoprotein particle clearance (GO:0034381)3.62372261
74tricarboxylic acid cycle (GO:0006099)3.58888364
75oxidative phosphorylation (GO:0006119)3.57846078
76regulation of mitochondrial translation (GO:0070129)3.56417900
77regulation of cholesterol homeostasis (GO:2000188)3.56308883
78positive regulation of lipid catabolic process (GO:0050996)3.55670062
79reverse cholesterol transport (GO:0043691)3.55497878
80indolalkylamine metabolic process (GO:0006586)3.54052050
81benzene-containing compound metabolic process (GO:0042537)3.51836959
82negative regulation of sterol transport (GO:0032372)3.51061144
83negative regulation of cholesterol transport (GO:0032375)3.51061144
84nucleobase biosynthetic process (GO:0046112)3.50959781
85plasma lipoprotein particle remodeling (GO:0034369)3.49946162
86protein-lipid complex remodeling (GO:0034368)3.49946162
87macromolecular complex remodeling (GO:0034367)3.49946162
88purine nucleobase biosynthetic process (GO:0009113)3.49639095
89* biotin metabolic process (GO:0006768)3.49571982
90cellular glucuronidation (GO:0052695)3.49417760
91dicarboxylic acid biosynthetic process (GO:0043650)3.49171710
92glycine metabolic process (GO:0006544)3.47495846
93bile acid and bile salt transport (GO:0015721)3.47189788
94regulation of cholesterol esterification (GO:0010872)3.44181593
95positive regulation of fatty acid oxidation (GO:0046321)3.43909357
96drug transport (GO:0015893)3.40290375
97regulation of sequestering of triglyceride (GO:0010889)3.35191390
98phospholipid homeostasis (GO:0055091)3.34743841
99response to mercury ion (GO:0046689)3.34331883
100exogenous drug catabolic process (GO:0042738)3.33534549
101cellular biogenic amine catabolic process (GO:0042402)3.33309185
102amine catabolic process (GO:0009310)3.33309185
103serine family amino acid biosynthetic process (GO:0009070)3.33151412
104regulation of cholesterol metabolic process (GO:0090181)3.31278968
105regulation of fatty acid beta-oxidation (GO:0031998)3.28465213
106* small molecule catabolic process (GO:0044282)3.25249642
107drug metabolic process (GO:0017144)3.24086923
108DNA strand elongation involved in DNA replication (GO:0006271)3.18494735
109tetrahydrofolate metabolic process (GO:0046653)3.07095860
110DNA strand elongation (GO:0022616)3.04132318
111proteasome assembly (GO:0043248)3.02128855
112telomere maintenance via semi-conservative replication (GO:0032201)3.00162490
113regulation of translational fidelity (GO:0006450)2.96532384
114ATP synthesis coupled proton transport (GO:0015986)2.96366391
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96366391
116L-methionine salvage (GO:0071267)2.94518772
117L-methionine biosynthetic process (GO:0071265)2.94518772
118amino acid salvage (GO:0043102)2.94518772
119oxaloacetate metabolic process (GO:0006107)2.91504419
120tRNA aminoacylation for protein translation (GO:0006418)2.90303812
121ribosome assembly (GO:0042255)2.88782631
122IMP biosynthetic process (GO:0006188)2.88384151
123mitochondrial RNA metabolic process (GO:0000959)2.87641235
124folic acid-containing compound biosynthetic process (GO:0009396)2.86985074
125sulfur amino acid biosynthetic process (GO:0000097)2.86801644
126tRNA aminoacylation (GO:0043039)2.85728427
127amino acid activation (GO:0043038)2.85728427
128establishment of integrated proviral latency (GO:0075713)2.85567690
129aldehyde catabolic process (GO:0046185)2.83162574
130DNA replication checkpoint (GO:0000076)2.81148265
131formation of translation preinitiation complex (GO:0001731)2.78300783
132rRNA modification (GO:0000154)2.78272430
133CENP-A containing nucleosome assembly (GO:0034080)2.78266656
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77927530
135chromatin remodeling at centromere (GO:0031055)2.73264049
136NADH metabolic process (GO:0006734)2.72448833
137cullin deneddylation (GO:0010388)2.69610836
138folic acid-containing compound metabolic process (GO:0006760)2.68629430
139pteridine-containing compound biosynthetic process (GO:0042559)2.66848423
140ubiquinone biosynthetic process (GO:0006744)2.64179378
141water-soluble vitamin biosynthetic process (GO:0042364)2.63005917
142protoporphyrinogen IX metabolic process (GO:0046501)2.62726329
143proline biosynthetic process (GO:0006561)2.62236137
144negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61477604
145ubiquinone metabolic process (GO:0006743)2.61257721
146methionine biosynthetic process (GO:0009086)2.61078107
147protoporphyrinogen IX biosynthetic process (GO:0006782)2.60304553
148respiratory electron transport chain (GO:0022904)2.59363047
149DNA unwinding involved in DNA replication (GO:0006268)2.59131187
150DNA ligation (GO:0006266)2.58723795
151DNA replication initiation (GO:0006270)2.57805311
152pseudouridine synthesis (GO:0001522)2.57290368
153respiratory chain complex IV assembly (GO:0008535)2.55676355
154methionine metabolic process (GO:0006555)2.55446128
155electron transport chain (GO:0022900)2.54744528
156IMP metabolic process (GO:0046040)2.54672270
157establishment of protein localization to mitochondrial membrane (GO:0090151)2.54134041
158pteridine-containing compound metabolic process (GO:0042558)2.53771252
159DNA replication-dependent nucleosome assembly (GO:0006335)2.53185872
160DNA replication-dependent nucleosome organization (GO:0034723)2.53185872
161telomere maintenance via recombination (GO:0000722)2.52817679
162aerobic respiration (GO:0009060)2.52641811
163aspartate family amino acid biosynthetic process (GO:0009067)2.52608742
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52492621
165mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51952687
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50658979
167somatic hypermutation of immunoglobulin genes (GO:0016446)2.50658979
168ribosome biogenesis (GO:0042254)2.50478226
169aspartate family amino acid metabolic process (GO:0009066)2.48767443
170alpha-amino acid biosynthetic process (GO:1901607)2.48214726
171mitotic recombination (GO:0006312)2.46498006
172anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46428114
173transcription from mitochondrial promoter (GO:0006390)2.45807000
174positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.42981403
175mitochondrial respiratory chain complex assembly (GO:0033108)2.41979493
176cholesterol biosynthetic process (GO:0006695)2.39463568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.26562069
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.92878734
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.26434212
4E2F7_22180533_ChIP-Seq_HELA_Human6.24901141
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.72273308
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.91981799
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.55560850
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54097692
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.89538826
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.86504301
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76361228
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.69262603
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.24514812
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24479797
15GABP_17652178_ChIP-ChIP_JURKAT_Human3.21278397
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09901684
17EST1_17652178_ChIP-ChIP_JURKAT_Human3.06930381
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02671343
19CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02184987
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96457433
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91015378
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.81306404
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.80283570
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72319708
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58136208
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52489309
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52378013
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33148983
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.29977113
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28455609
31* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27645885
32CLOCK_20551151_ChIP-Seq_293T_Human2.27581379
33AR_21909140_ChIP-Seq_LNCAP_Human2.26534422
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23339391
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20953159
36FOXM1_23109430_ChIP-Seq_U2OS_Human2.19290172
37* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09310577
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04444704
39DCP1A_22483619_ChIP-Seq_HELA_Human2.04037817
40ELK1_19687146_ChIP-ChIP_HELA_Human2.03484258
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01289535
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0360434
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.99463836
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96536962
45XRN2_22483619_ChIP-Seq_HELA_Human1.95534054
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94319432
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90510065
48TTF2_22483619_ChIP-Seq_HELA_Human1.87915874
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87783710
50* VDR_23849224_ChIP-Seq_CD4+_Human1.87528350
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85753229
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85644140
53* GABP_19822575_ChIP-Seq_HepG2_Human1.84547909
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.82551232
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81312301
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76851227
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74703171
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71739239
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69844896
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68875199
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.65334649
62KDM5A_27292631_Chip-Seq_BREAST_Human1.62154678
63* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59884227
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59323895
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.55572291
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48316342
67MYC_18940864_ChIP-ChIP_HL60_Human1.46296723
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44811221
69ZNF263_19887448_ChIP-Seq_K562_Human1.44247970
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43728352
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38688772
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.38601357
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37606454
74* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34408891
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33948720
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28515655
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25722432
78* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24856574
79GATA1_22025678_ChIP-Seq_K562_Human1.24544077
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20744780
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19931273
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10867806
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10654223
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10641091
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10260942
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.06761243
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04999725
88IRF1_19129219_ChIP-ChIP_H3396_Human1.04822751
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04780641
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.04468520
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.03528954
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03095353
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03063735
94GATA4_25053715_ChIP-Seq_YYC3_Human1.00751184
95HTT_18923047_ChIP-ChIP_STHdh_Human0.99066419
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98303521
97* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97207009
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.96969822
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96903291
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96361212
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96211717
102* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95799202
103TFEB_21752829_ChIP-Seq_HELA_Human0.93789224
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91501632
105TBX20_22328084_ChIP-Seq_HEART_Mouse0.91173222
106TBX20_22080862_ChIP-Seq_HEART_Mouse0.91173222
107ZNF274_21170338_ChIP-Seq_K562_Hela0.90763246
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.89823525
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.89411218
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89310003
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89187797
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88799361
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87622733
114RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87337798
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86798785
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86431318
117CHD1_26751641_Chip-Seq_LNCaP_Human0.86051803
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85556407
119* IGF1R_20145208_ChIP-Seq_DFB_Human0.85225845
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84553912
121CIITA_25753668_ChIP-Seq_RAJI_Human0.83875503
122LXR_22292898_ChIP-Seq_THP-1_Human0.83862246
123* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82039029
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81404378
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80176688
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80114408
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.79119453
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77106852
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77008870
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76655847
131* FOXO3_23340844_ChIP-Seq_DLD1_Human0.76545284
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76341409
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74595799
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74595799
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.74574023
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74030977
137EWS_26573619_Chip-Seq_HEK293_Human0.73733656
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73396601
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69845130
140RACK7_27058665_Chip-Seq_MCF-7_Human0.69110660
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68750683
142TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68721178
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.67974853
144TRIM28_21343339_ChIP-Seq_HEK293_Human0.67385555
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67362186
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66474616
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66214498
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.66123404
149EGR1_19032775_ChIP-ChIP_M12_Human0.65994218
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65789446
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65646541
152* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64810646
153* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63672753
154SOX2_20726797_ChIP-Seq_SW620_Human0.63549742
155PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62252066
156NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61644185
157GATA1_19941826_ChIP-Seq_K562_Human0.61595863
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.61048846
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60617413
160SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60050797
161GATA6_25053715_ChIP-Seq_YYC3_Human0.59869669
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58148206
163CEBPB_22108803_ChIP-Seq_LS180_Human0.57747228
164GATA3_24758297_ChIP-Seq_MCF-7_Human0.57171263
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.56752996
166STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56568424
167GATA2_19941826_ChIP-Seq_K562_Human0.56192077
168CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.55943585
169* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55111487
170BCAT_22108803_ChIP-Seq_LS180_Human0.53941337
171CREB1_26743006_Chip-Seq_LNCaP_Human0.52921051
172CTCF_27219007_Chip-Seq_Bcells_Human0.52727325
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52181142
174CBP_21632823_ChIP-Seq_H3396_Human0.52174767
175FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51988800
176ESET_19884257_ChIP-Seq_ESCs_Mouse0.50417838
177RARB_24833708_ChIP-Seq_LIVER_Mouse0.50009529
178AR_20517297_ChIP-Seq_VCAP_Human0.48134357
179* TAF2_19829295_ChIP-Seq_ESCs_Human0.48102963
180MYC_19915707_ChIP-ChIP_AK7_Human0.48070638
181OCT4_20526341_ChIP-Seq_ESCs_Human0.47449800
182ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.47130131
183PIAS1_25552417_ChIP-Seq_VCAP_Human0.47118776
184FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46639445
185BCOR_27268052_Chip-Seq_Bcells_Human0.46030032
186P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.45016102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.24371431
2MP0005360_urolithiasis6.90481986
3MP0005365_abnormal_bile_salt5.46685620
4MP0005085_abnormal_gallbladder_physiolo5.44339146
5MP0008875_abnormal_xenobiotic_pharmacok4.32560640
6MP0003806_abnormal_nucleotide_metabolis3.53091429
7MP0003252_abnormal_bile_duct3.47378213
8MP0010329_abnormal_lipoprotein_level3.31005324
9MP0005332_abnormal_amino_acid3.19641733
10MP0010094_abnormal_chromosome_stability3.09751404
11MP0003195_calcinosis3.03055552
12MP0008058_abnormal_DNA_repair2.99593063
13MP0003718_maternal_effect2.71861551
14MP0003693_abnormal_embryo_hatching2.69420256
15MP0004957_abnormal_blastocyst_morpholog2.67310797
16MP0001666_abnormal_nutrient_absorption2.60294053
17MP0005083_abnormal_biliary_tract2.56371364
18MP0009840_abnormal_foam_cell2.53244292
19MP0003111_abnormal_nucleus_morphology2.49919223
20MP0004147_increased_porphyrin_level2.39809648
21MP0004019_abnormal_vitamin_homeostasis2.36080528
22MP0002118_abnormal_lipid_homeostasis2.25583041
23MP0005670_abnormal_white_adipose2.17411404
24MP0003077_abnormal_cell_cycle2.14886134
25MP0003191_abnormal_cellular_cholesterol2.14501295
26MP0008877_abnormal_DNA_methylation2.04508455
27MP0002837_dystrophic_cardiac_calcinosis1.99575025
28MP0000609_abnormal_liver_physiology1.96054517
29MP0008057_abnormal_DNA_replication1.91103389
30MP0008932_abnormal_embryonic_tissue1.90726993
31MP0002138_abnormal_hepatobiliary_system1.90640005
32MP0004130_abnormal_muscle_cell1.90025335
33MP0004043_abnormal_pH_regulation1.87924144
34MP0009643_abnormal_urine_homeostasis1.85901944
35MP0005319_abnormal_enzyme/_coenzyme1.83507361
36MP0005584_abnormal_enzyme/coenzyme_acti1.71319714
37MP0003941_abnormal_skin_development1.70367936
38MP0005666_abnormal_adipose_tissue1.64940572
39MP0008995_early_reproductive_senescence1.62215375
40MP0006036_abnormal_mitochondrial_physio1.52722478
41MP0003868_abnormal_feces_composition1.52362237
42MP0008007_abnormal_cellular_replicative1.50903385
43MP0001764_abnormal_homeostasis1.48732932
44MP0003786_premature_aging1.46160368
45MP0001529_abnormal_vocalization1.42056916
46MP0004145_abnormal_muscle_electrophysio1.41991404
47MP0003123_paternal_imprinting1.37687309
48MP0003705_abnormal_hypodermis_morpholog1.36445381
49MP0003186_abnormal_redox_activity1.35719100
50MP0002938_white_spotting1.34519537
51MP0001756_abnormal_urination1.30351374
52MP0005451_abnormal_body_composition1.29971982
53MP0002971_abnormal_brown_adipose1.29761521
54MP0004233_abnormal_muscle_weight1.29546584
55MP0005636_abnormal_mineral_homeostasis1.27495363
56MP0000372_irregular_coat_pigmentation1.25194328
57MP0001730_embryonic_growth_arrest1.24909412
58MP0005535_abnormal_body_temperature1.24067683
59MP0001929_abnormal_gametogenesis1.23477351
60MP0009672_abnormal_birth_weight1.18658924
61MP0002090_abnormal_vision1.17081275
62MP0006292_abnormal_olfactory_placode1.15894134
63MP0002078_abnormal_glucose_homeostasis1.15446265
64MP0008789_abnormal_olfactory_epithelium1.11785110
65MP0000358_abnormal_cell_content/1.10239681
66MP0004185_abnormal_adipocyte_glucose1.07753446
67MP0005410_abnormal_fertilization1.06898213
68MP0002876_abnormal_thyroid_physiology1.05581755
69MP0003136_yellow_coat_color1.04509795
70MP0003646_muscle_fatigue1.03695769
71MP0001727_abnormal_embryo_implantation1.03203699
72MP0005334_abnormal_fat_pad1.02880259
73MP0005379_endocrine/exocrine_gland_phen1.02522437
74MP0005375_adipose_tissue_phenotype1.02182431
75MP0002210_abnormal_sex_determination1.02038550
76MP0002160_abnormal_reproductive_system1.01416031
77MP0001672_abnormal_embryogenesis/_devel1.00586902
78MP0005380_embryogenesis_phenotype1.00586902
79MP0001293_anophthalmia1.00466840
80MP0001697_abnormal_embryo_size1.00201629
81MP0000598_abnormal_liver_morphology0.98511925
82MP0003567_abnormal_fetal_cardiomyocyte0.97821549
83MP0002234_abnormal_pharynx_morphology0.95731920
84MP0000653_abnormal_sex_gland0.95200674
85MP0001145_abnormal_male_reproductive0.94078522
86MP0001661_extended_life_span0.93256602
87MP0001765_abnormal_ion_homeostasis0.92911978
88MP0003698_abnormal_male_reproductive0.91717682
89MP0006072_abnormal_retinal_apoptosis0.91494349
90MP0003656_abnormal_erythrocyte_physiolo0.90393442
91MP0000749_muscle_degeneration0.90087252
92MP0003984_embryonic_growth_retardation0.89810656
93MP0002088_abnormal_embryonic_growth/wei0.88609897
94MP0005647_abnormal_sex_gland0.88404204
95MP0005084_abnormal_gallbladder_morpholo0.87880277
96MP0009642_abnormal_blood_homeostasis0.86528017
97MP0003011_delayed_dark_adaptation0.85826056
98MP0005394_taste/olfaction_phenotype0.85754764
99MP0005499_abnormal_olfactory_system0.85754764
100MP0005187_abnormal_penis_morphology0.85750058
101MP0005395_other_phenotype0.85581720
102MP0002080_prenatal_lethality0.85343760
103MP0005330_cardiomyopathy0.83644255
104MP0005645_abnormal_hypothalamus_physiol0.83246070
105MP0002136_abnormal_kidney_physiology0.82490349
106MP0005220_abnormal_exocrine_pancreas0.82164110
107MP0001984_abnormal_olfaction0.81914223
108MP0005253_abnormal_eye_physiology0.81900747
109MP0000604_amyloidosis0.81317079
110MP0005448_abnormal_energy_balance0.78984321
111MP0000350_abnormal_cell_proliferation0.78720351
112MP0003121_genomic_imprinting0.78654444
113MP0002084_abnormal_developmental_patter0.77663053
114MP0000230_abnormal_systemic_arterial0.77621603
115MP0006035_abnormal_mitochondrial_morpho0.77449648
116MP0003315_abnormal_perineum_morphology0.76942900
117MP0010234_abnormal_vibrissa_follicle0.76586201
118MP0003329_amyloid_beta_deposits0.74652627
119MP0002163_abnormal_gland_morphology0.72297748
120MP0003690_abnormal_glial_cell0.72182650
121MP0010368_abnormal_lymphatic_system0.71809062
122MP0000313_abnormal_cell_death0.70938223
123MP0005551_abnormal_eye_electrophysiolog0.70613202
124MP0002161_abnormal_fertility/fecundity0.70316399
125MP0009115_abnormal_fat_cell0.69959045
126MP0005058_abnormal_lysosome_morphology0.69589072
127MP0009697_abnormal_copulation0.69284886
128MP0002085_abnormal_embryonic_tissue0.69253663
129MP0005376_homeostasis/metabolism_phenot0.68921445
130MP0009764_decreased_sensitivity_to0.68413713
131MP0005266_abnormal_metabolism0.67875979
132MP0003953_abnormal_hormone_level0.67452597
133MP0009763_increased_sensitivity_to0.65909690
134MP0004036_abnormal_muscle_relaxation0.64604678
135MP0003959_abnormal_lean_body0.64542270
136MP0008961_abnormal_basal_metabolism0.63568646
137MP0002970_abnormal_white_adipose0.61986930
138MP0002269_muscular_atrophy0.61131914
139MP0008469_abnormal_protein_level0.59918309
140MP0002254_reproductive_system_inflammat0.59230610
141MP0009780_abnormal_chondrocyte_physiolo0.57658242
142MP0000003_abnormal_adipose_tissue0.54541005
143MP0000751_myopathy0.53927834
144MP0000013_abnormal_adipose_tissue0.53790366
145MP0005408_hypopigmentation0.53291404
146MP0000747_muscle_weakness0.53080820
147MP0002822_catalepsy0.51457980
148MP0006138_congestive_heart_failure0.50604259
149MP0004087_abnormal_muscle_fiber0.50040415
150MP0002168_other_aberrant_phenotype0.48123366
151MP0002796_impaired_skin_barrier0.47969960
152MP0009765_abnormal_xenobiotic_induced0.47316745
153MP0005620_abnormal_muscle_contractility0.47157405
154MP0004215_abnormal_myocardial_fiber0.46720515
155MP0001944_abnormal_pancreas_morphology0.46669715
156MP0003638_abnormal_response/metabolism_0.45733459
157MP0001544_abnormal_cardiovascular_syste0.44950418
158MP0005385_cardiovascular_system_phenoty0.44950418
159MP0005452_abnormal_adipose_tissue0.44392412
160MP0008775_abnormal_heart_ventricle0.43448890
161MP0002972_abnormal_cardiac_muscle0.43319513
162MP0000538_abnormal_urinary_bladder0.42810871
163MP0002928_abnormal_bile_duct0.42563723
164MP0003221_abnormal_cardiomyocyte_apopto0.42168991

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.91872306
2Intrahepatic cholestasis (HP:0001406)5.59291493
3Deep venous thrombosis (HP:0002625)5.23365009
4Xanthomatosis (HP:0000991)5.13946234
5* Hyperglycinuria (HP:0003108)5.04843998
6Ketosis (HP:0001946)4.97376898
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.85834092
8* Abnormality of glycine metabolism (HP:0010895)4.64648250
9* Abnormality of serine family amino acid metabolism (HP:0010894)4.64648250
10Hypoglycemic coma (HP:0001325)4.63339643
11* Hyperammonemia (HP:0001987)4.59744855
12Ketoacidosis (HP:0001993)4.57594310
13Hyperlipoproteinemia (HP:0010980)4.41136550
14Abnormality of glycolysis (HP:0004366)4.39626505
15Abnormality of fatty-acid metabolism (HP:0004359)4.36584174
16Increased serum pyruvate (HP:0003542)4.26535874
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25749849
18Hypobetalipoproteinemia (HP:0003563)4.24133413
19Prolonged partial thromboplastin time (HP:0003645)4.16457092
20Complement deficiency (HP:0004431)4.08664676
21* Hyperglycinemia (HP:0002154)4.07093681
22Gout (HP:0001997)3.88639424
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60728487
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.60604145
25Dicarboxylic aciduria (HP:0003215)3.60604145
26* Acute encephalopathy (HP:0006846)3.59251399
27Hypolipoproteinemia (HP:0010981)3.59085125
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.56787438
29Epidermoid cyst (HP:0200040)3.54555959
30Hypoalphalipoproteinemia (HP:0003233)3.51008443
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.50502237
32Acute necrotizing encephalopathy (HP:0006965)3.44929857
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38425453
34Abnormal mitochondria in muscle tissue (HP:0008316)3.35750998
35Abnormality of purine metabolism (HP:0004352)3.33920024
36Generalized aminoaciduria (HP:0002909)3.25016413
37Fat malabsorption (HP:0002630)3.16643420
38Abnormality of the common coagulation pathway (HP:0010990)3.08034356
39Microvesicular hepatic steatosis (HP:0001414)3.02557259
40Delayed CNS myelination (HP:0002188)3.01913306
41* Metabolic acidosis (HP:0001942)3.00937924
42Increased CSF lactate (HP:0002490)2.99307475
43Joint hemorrhage (HP:0005261)2.97554903
44Abnormality of methionine metabolism (HP:0010901)2.97250543
45Abnormality of nucleobase metabolism (HP:0010932)2.96928536
46* Lethargy (HP:0001254)2.92047488
47Proximal tubulopathy (HP:0000114)2.87792491
48Abnormality of the anterior horn cell (HP:0006802)2.85492334
49Degeneration of anterior horn cells (HP:0002398)2.85492334
50Mitochondrial inheritance (HP:0001427)2.84694822
51Myoglobinuria (HP:0002913)2.84602739
52Increased purine levels (HP:0004368)2.84348096
53Hyperuricemia (HP:0002149)2.84348096
54Abnormality of the intrinsic pathway (HP:0010989)2.84126354
55Progressive macrocephaly (HP:0004481)2.81979576
56* Abnormality of serum amino acid levels (HP:0003112)2.80025838
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78533372
58Abnormality of alanine metabolism (HP:0010916)2.78533372
59Hyperalaninemia (HP:0003348)2.78533372
60Abnormality of complement system (HP:0005339)2.78325812
61Increased serum lactate (HP:0002151)2.77050502
62Cerebral edema (HP:0002181)2.75673333
63Conjugated hyperbilirubinemia (HP:0002908)2.75247672
64Hepatocellular necrosis (HP:0001404)2.71473837
65Lipid accumulation in hepatocytes (HP:0006561)2.70660961
66Hypoglycemic seizures (HP:0002173)2.70341909
67Hyperbilirubinemia (HP:0002904)2.69646260
68* Lactic acidosis (HP:0003128)2.67478827
69Hypercholesterolemia (HP:0003124)2.67144598
70Abnormality of proline metabolism (HP:0010907)2.62570731
71Hydroxyprolinuria (HP:0003080)2.62570731
72* Vomiting (HP:0002013)2.52888846
73Skin nodule (HP:0200036)2.50494138
74Increased hepatocellular lipid droplets (HP:0006565)2.50363838
75Hyperinsulinemic hypoglycemia (HP:0000825)2.49355263
76Alkalosis (HP:0001948)2.46777445
77Hepatocellular carcinoma (HP:0001402)2.42603832
78Late onset (HP:0003584)2.41424030
79Multiple enchondromatosis (HP:0005701)2.41031343
80Chromsome breakage (HP:0040012)2.39726891
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39321168
82Vascular calcification (HP:0004934)2.38396782
83Abnormality of urine glucose concentration (HP:0011016)2.38208144
84Glycosuria (HP:0003076)2.38208144
85Type I transferrin isoform profile (HP:0003642)2.36862340
86Neoplasm of the adrenal gland (HP:0100631)2.34494581
87Birth length less than 3rd percentile (HP:0003561)2.33302779
88Steatorrhea (HP:0002570)2.32860504
89Reduced antithrombin III activity (HP:0001976)2.30622856
90Irritability (HP:0000737)2.28928367
91Malnutrition (HP:0004395)2.24383931
92Abnormality of the labia minora (HP:0012880)2.23411934
93Abnormality of pyrimidine metabolism (HP:0004353)2.22945562
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19926688
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19926688
96Abnormality of cells of the erythroid lineage (HP:0012130)2.19736173
97Neonatal onset (HP:0003623)2.19627065
98Abnormal number of erythroid precursors (HP:0012131)2.18889114
99Sensorimotor neuropathy (HP:0007141)2.18021215
100Exercise intolerance (HP:0003546)2.17872906
101Abnormal gallbladder morphology (HP:0012437)2.15741624
102Increased intramyocellular lipid droplets (HP:0012240)2.15421790
103Cardiovascular calcification (HP:0011915)2.14347770
104Myocardial infarction (HP:0001658)2.13951782
105Cholelithiasis (HP:0001081)2.13242140
106Enlarged kidneys (HP:0000105)2.13061510
107Abnormal cartilage morphology (HP:0002763)2.11899624
108Hyperglycemia (HP:0003074)2.11705495
109Respiratory failure (HP:0002878)2.10784563
110Rhabdomyolysis (HP:0003201)2.08659870
111Progressive muscle weakness (HP:0003323)2.08452345
1123-Methylglutaconic aciduria (HP:0003535)2.07487154
113Hepatic necrosis (HP:0002605)2.06935655
114* Pancreatitis (HP:0001733)2.06355303
115Spastic diplegia (HP:0001264)2.06264219
116Increased muscle lipid content (HP:0009058)2.05806667
117Methylmalonic aciduria (HP:0012120)2.03967866
118Nausea (HP:0002018)2.02087282
119CNS demyelination (HP:0007305)2.00785253
120Ragged-red muscle fibers (HP:0003200)1.99324633
121Methylmalonic acidemia (HP:0002912)1.99239185
122Abnormal glycosylation (HP:0012345)1.98171678
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98171678
124Abnormal protein N-linked glycosylation (HP:0012347)1.98171678
125Abnormal protein glycosylation (HP:0012346)1.98171678
126Hypokalemic alkalosis (HP:0001949)1.97959457
127Testicular atrophy (HP:0000029)1.97756140
128Renal Fanconi syndrome (HP:0001994)1.97476724
129Brushfield spots (HP:0001088)1.95524457
130Exercise-induced muscle cramps (HP:0003710)1.94785161
131Hyperactive renin-angiotensin system (HP:0000841)1.92930433
132Systemic lupus erythematosus (HP:0002725)1.92091132
133Abnormal gallbladder physiology (HP:0012438)1.91906020
134Cholecystitis (HP:0001082)1.91906020
135Renal cortical cysts (HP:0000803)1.90227765
136Symptomatic seizures (HP:0011145)1.89509321
137Colon cancer (HP:0003003)1.88302222
138Reticulocytopenia (HP:0001896)1.87938014
139Increased circulating renin level (HP:0000848)1.86863008
140Cerebral palsy (HP:0100021)1.86698248
141Rickets (HP:0002748)1.83717978
142Abnormality of reticulocytes (HP:0004312)1.83179233
143Nephrolithiasis (HP:0000787)1.82026326
144Reticulocytosis (HP:0001923)1.80925073
145Meckel diverticulum (HP:0002245)1.79475322
146Abnormal enzyme/coenzyme activity (HP:0012379)1.79352218
147Exercise-induced myalgia (HP:0003738)1.78776944
148Spontaneous abortion (HP:0005268)1.76972312
149Metabolic alkalosis (HP:0200114)1.76075979
150Hypertriglyceridemia (HP:0002155)1.75710374
151Abnormality of the gallbladder (HP:0005264)1.73748675
152Abnormality of vitamin metabolism (HP:0100508)1.72620141
153Abnormality of the ileum (HP:0001549)1.67614712
154Leukodystrophy (HP:0002415)1.66139225
155Pancreatic islet-cell hyperplasia (HP:0004510)1.64631567
156Secondary amenorrhea (HP:0000869)1.63521120
157Abnormal lung lobation (HP:0002101)1.62451727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.62759884
2BUB13.59138584
3SIK13.37652515
4VRK23.35496290
5TRIB33.29581738
6EIF2AK13.25455694
7PBK3.02316985
8INSRR2.91014175
9WNK42.87826792
10CDC72.87478800
11ERN12.85973840
12TTK2.82337986
13TAOK32.67224457
14FGFR42.60709424
15PDK32.57480748
16PDK42.57480748
17EIF2AK32.49274754
18SRPK12.29617094
19TSSK62.18923997
20WNK32.17781622
21ZAK2.15695798
22PKN22.13267914
23MST1R2.00204082
24VRK11.96700761
25PDK21.90032490
26OXSR11.89516690
27MST41.78251817
28WEE11.77166400
29PLK41.76275033
30PLK31.72917184
31SCYL21.69275682
32FRK1.68570570
33PINK11.67547252
34TAF11.61955538
35LATS11.60319366
36NUAK11.54849186
37BRSK21.51686912
38PLK11.47994253
39MAP2K41.44498167
40CAMK1D1.43228339
41TIE11.41471235
42PIM21.41451362
43LMTK21.40485335
44STK38L1.39605005
45TRIM281.36836350
46STK391.35841987
47PTK61.34870702
48EEF2K1.33280196
49ERBB41.32978768
50NME11.32400862
51STK161.31495663
52PRKAA21.25639205
53PHKG21.22106426
54PHKG11.22106426
55ATR1.21857488
56BMPR1B1.21153786
57CSNK1G31.20435709
58MAPK111.17570658
59CHEK21.16388801
60NME21.16352618
61MKNK11.15617261
62RIPK11.14399125
63CSNK1G11.12924153
64MAP3K71.12246870
65CDK71.06700075
66MET1.04040483
67MKNK21.03920607
68FGFR21.03792855
69FLT31.03775129
70RPS6KB21.03192018
71AURKA1.02233629
72PIK3CG1.02029571
73CAMK1G1.01830576
74BRSK11.01547071
75PRKAA10.99707275
76MAP3K30.98052829
77TTN0.96420059
78NEK90.95891791
79AURKB0.95820953
80DAPK20.94609265
81MAP4K20.94571496
82MAP3K20.93949374
83EPHB10.93773821
84CSNK1G20.93153660
85CSNK1A1L0.92028174
86MYLK0.90018407
87PDPK10.87806051
88ACVR1B0.85808521
89EIF2AK20.83948342
90CCNB10.83030465
91PIK3CA0.82482077
92RAF10.82450667
93OBSCN0.82110555
94ATM0.81484252
95SGK4940.80939947
96SGK2230.80939947
97NEK10.80909307
98MAPK150.78790555
99CHEK10.77762959
100JAK20.77236026
101MUSK0.76303955
102ICK0.75023226
103SGK30.74405023
104EPHB20.74160921
105ABL20.73943719
106MAPK120.72781824
107GSK3A0.71388626
108NEK20.71302289
109BRAF0.70702918
110PRKACG0.69075830
111MAP2K10.68794163
112PDGFRA0.67933883
113CSNK2A20.67394481
114KSR20.66107476
115PRKCI0.65150347
116MAP2K30.65021565
117CSNK1E0.63394008
118PRKD30.63331880
119MAPKAPK30.60985561
120PLK20.60719679
121PNCK0.60715906
122CSNK2A10.60611201
123RET0.60491428
124TGFBR20.60265970
125PAK30.60258108
126CDK10.59659131
127BCR0.58305941
128PRKCZ0.58238419
129CAMK2G0.57995606
130DYRK20.57270286
131PDK10.56332448
132FER0.56170632
133GRK10.55745031
134MAP3K100.55641240
135ERBB20.55165757
136PRKD10.54843701
137STK40.54836422
138DAPK10.54205221
139MAP3K80.53847700
140CDK20.53684496
141MAP2K20.53678573
142PRKCH0.53292574
143SMG10.53000334
144MAP3K110.52986693
145PTK20.52478506
146MAPKAPK50.51556704
147STK380.49748648
148AKT20.49318684
149PRKDC0.48966594
150RPS6KA50.48232677
151STK30.48011902
152MAP3K10.46697650
153DYRK30.46518812
154CDK80.45952683
155ARAF0.44676188
156DYRK1B0.44075371
157TNIK0.43818075
158SGK20.42445666
159MAPK40.41003534
160WNK10.39398097
161PASK0.39056317
162CASK0.38890169
163ALK0.38821977
164MTOR0.38810570
165MAP3K120.38636433
166IRAK30.37565538
167ERBB30.37429825
168JAK10.37096019
169DAPK30.35892807
170CSNK1A10.35866994
171RPS6KB10.35738115
172GRK60.35709000
173AKT30.35645782
174KDR0.34874420
175FGFR30.33519753
176PKN10.33070877
177LATS20.32131432
178NTRK10.31568283
179MAP2K60.29941982
180TYK20.29665972
181EPHA30.27091604
182PRKACA0.26839234
183IGF1R0.26518149

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.50807593
2Nitrogen metabolism_Homo sapiens_hsa009103.15785810
3* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.07514394
4Fatty acid degradation_Homo sapiens_hsa000713.00858378
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93563943
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89042173
7* Propanoate metabolism_Homo sapiens_hsa006402.85095620
8* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81277927
9Butanoate metabolism_Homo sapiens_hsa006502.59810232
10Arginine biosynthesis_Homo sapiens_hsa002202.56537361
11Tryptophan metabolism_Homo sapiens_hsa003802.53932940
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43826832
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41472542
14Fatty acid metabolism_Homo sapiens_hsa012122.37957425
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22460065
16PPAR signaling pathway_Homo sapiens_hsa033202.17030725
17DNA replication_Homo sapiens_hsa030302.14373762
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12118000
19Peroxisome_Homo sapiens_hsa041462.10839173
20Proteasome_Homo sapiens_hsa030502.06587651
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03714799
22Mismatch repair_Homo sapiens_hsa034302.03119757
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00896349
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99991347
25Pyruvate metabolism_Homo sapiens_hsa006201.89501832
26beta-Alanine metabolism_Homo sapiens_hsa004101.86888115
27Complement and coagulation cascades_Homo sapiens_hsa046101.83589009
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70525672
29Sulfur metabolism_Homo sapiens_hsa009201.65464371
30* Carbon metabolism_Homo sapiens_hsa012001.56156730
31Base excision repair_Homo sapiens_hsa034101.55583374
32Histidine metabolism_Homo sapiens_hsa003401.54528764
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54165628
34Fatty acid elongation_Homo sapiens_hsa000621.53574694
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53298385
36Bile secretion_Homo sapiens_hsa049761.48531551
37Non-homologous end-joining_Homo sapiens_hsa034501.47898636
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45379252
39Chemical carcinogenesis_Homo sapiens_hsa052041.44372548
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41740750
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39524592
42RNA polymerase_Homo sapiens_hsa030201.39191285
43Homologous recombination_Homo sapiens_hsa034401.38728733
44Phenylalanine metabolism_Homo sapiens_hsa003601.38542205
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.36322589
46Starch and sucrose metabolism_Homo sapiens_hsa005001.35042570
47Caffeine metabolism_Homo sapiens_hsa002321.33467371
48Nucleotide excision repair_Homo sapiens_hsa034201.33261294
49Ribosome_Homo sapiens_hsa030101.32762310
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.28689563
51RNA transport_Homo sapiens_hsa030131.27222753
52Selenocompound metabolism_Homo sapiens_hsa004501.26093420
53Fat digestion and absorption_Homo sapiens_hsa049751.24845207
54Biosynthesis of amino acids_Homo sapiens_hsa012301.21560913
55Retinol metabolism_Homo sapiens_hsa008301.19867343
56Tyrosine metabolism_Homo sapiens_hsa003501.18716255
57Protein export_Homo sapiens_hsa030601.18356688
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17654017
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.12394696
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12120010
61Folate biosynthesis_Homo sapiens_hsa007901.09050881
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.08414894
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.06704761
64Fanconi anemia pathway_Homo sapiens_hsa034601.06209719
65Huntingtons disease_Homo sapiens_hsa050161.05085088
66Glycerolipid metabolism_Homo sapiens_hsa005611.03343481
67Staphylococcus aureus infection_Homo sapiens_hsa051501.00867047
68Pyrimidine metabolism_Homo sapiens_hsa002401.00783302
69Arginine and proline metabolism_Homo sapiens_hsa003300.99914594
70Basal transcription factors_Homo sapiens_hsa030220.99022686
71Fatty acid biosynthesis_Homo sapiens_hsa000610.98879503
72ABC transporters_Homo sapiens_hsa020100.95756308
73Spliceosome_Homo sapiens_hsa030400.95357526
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89636190
75Cell cycle_Homo sapiens_hsa041100.87362965
76Vitamin digestion and absorption_Homo sapiens_hsa049770.86915705
77RNA degradation_Homo sapiens_hsa030180.86460649
78Lysine degradation_Homo sapiens_hsa003100.86218768
79Sulfur relay system_Homo sapiens_hsa041220.83674675
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81719791
81Steroid biosynthesis_Homo sapiens_hsa001000.79669548
82Purine metabolism_Homo sapiens_hsa002300.74141949
83Vitamin B6 metabolism_Homo sapiens_hsa007500.70804562
84Glutathione metabolism_Homo sapiens_hsa004800.70023328
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61212963
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61166008
87Pentose phosphate pathway_Homo sapiens_hsa000300.55815811
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52107169
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.51543868
90N-Glycan biosynthesis_Homo sapiens_hsa005100.51376718
91* Metabolic pathways_Homo sapiens_hsa011000.50394028
92Insulin resistance_Homo sapiens_hsa049310.47311936
93mRNA surveillance pathway_Homo sapiens_hsa030150.46598551
94Fructose and mannose metabolism_Homo sapiens_hsa000510.46586808
95Oocyte meiosis_Homo sapiens_hsa041140.40100958
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37066296
97Galactose metabolism_Homo sapiens_hsa000520.36366425
98AMPK signaling pathway_Homo sapiens_hsa041520.35269544
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33325199
100Glucagon signaling pathway_Homo sapiens_hsa049220.31741074
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30226428
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.26911150
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23283129
104Oxidative phosphorylation_Homo sapiens_hsa001900.21178016
105Prion diseases_Homo sapiens_hsa050200.20547948
106Insulin signaling pathway_Homo sapiens_hsa049100.17835233
107Protein digestion and absorption_Homo sapiens_hsa049740.17215103
108Linoleic acid metabolism_Homo sapiens_hsa005910.16615855
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16296623
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14535840
111Parkinsons disease_Homo sapiens_hsa050120.12670885
112One carbon pool by folate_Homo sapiens_hsa006700.09287617
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08384807
114Thyroid hormone synthesis_Homo sapiens_hsa049180.05458120
115Alzheimers disease_Homo sapiens_hsa050100.04954805
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03204725
117Renin-angiotensin system_Homo sapiens_hsa046140.00909991
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0754492
119Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0675123
120Regulation of autophagy_Homo sapiens_hsa04140-0.0548796
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0404508
122Type II diabetes mellitus_Homo sapiens_hsa04930-0.0364937
123Cardiac muscle contraction_Homo sapiens_hsa04260-0.0184840
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0181067
125Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0180790
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0091699
127Mineral absorption_Homo sapiens_hsa04978-0.0090633

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »