PCDH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47891374
2neuron cell-cell adhesion (GO:0007158)5.41996656
3vocalization behavior (GO:0071625)5.28389090
4locomotory exploration behavior (GO:0035641)5.22445615
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21896090
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08206519
7synaptic vesicle maturation (GO:0016188)5.03863858
8synaptic vesicle exocytosis (GO:0016079)4.75559181
9regulation of glutamate receptor signaling pathway (GO:1900449)4.61905576
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.56668653
11protein localization to synapse (GO:0035418)4.53193015
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52761929
13glutamate secretion (GO:0014047)4.45350168
14dendritic spine morphogenesis (GO:0060997)4.43949072
15regulation of synaptic vesicle exocytosis (GO:2000300)4.37066830
16presynaptic membrane assembly (GO:0097105)4.27184611
17gamma-aminobutyric acid transport (GO:0015812)4.21639954
18neurotransmitter-gated ion channel clustering (GO:0072578)4.20512644
19exploration behavior (GO:0035640)4.20111497
20layer formation in cerebral cortex (GO:0021819)4.16003832
21neuronal action potential propagation (GO:0019227)4.15657887
22glutamate receptor signaling pathway (GO:0007215)4.12751087
23regulation of synapse structural plasticity (GO:0051823)4.12330955
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.10122304
25synaptic transmission, glutamatergic (GO:0035249)4.01570806
26neurotransmitter secretion (GO:0007269)3.97760441
27neuron recognition (GO:0008038)3.96043894
28postsynaptic membrane organization (GO:0001941)3.94932583
29regulation of neuronal synaptic plasticity (GO:0048168)3.94599866
30neuron-neuron synaptic transmission (GO:0007270)3.94445009
31presynaptic membrane organization (GO:0097090)3.87769145
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85875285
33auditory behavior (GO:0031223)3.82939505
34transmission of nerve impulse (GO:0019226)3.81676413
35regulation of synaptic vesicle transport (GO:1902803)3.78972630
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.73762170
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66442676
38proline transport (GO:0015824)3.62919236
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61341342
40response to auditory stimulus (GO:0010996)3.61244070
41positive regulation of membrane potential (GO:0045838)3.59397568
42axonal fasciculation (GO:0007413)3.56989442
43long-term memory (GO:0007616)3.56737617
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55338659
45regulation of dendritic spine morphogenesis (GO:0061001)3.47066184
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.46029812
47L-amino acid import (GO:0043092)3.45151831
48positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44203411
49prepulse inhibition (GO:0060134)3.42999033
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.42732281
51dendrite morphogenesis (GO:0048813)3.41862386
52neurotransmitter transport (GO:0006836)3.40378232
53regulation of postsynaptic membrane potential (GO:0060078)3.39924140
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39361804
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.38815982
56pyrimidine nucleobase catabolic process (GO:0006208)3.37951903
57sodium ion export (GO:0071436)3.35318369
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35100735
59synapse assembly (GO:0007416)3.29021709
60establishment of mitochondrion localization (GO:0051654)3.27590815
61response to histamine (GO:0034776)3.27589007
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24873578
63long-term synaptic potentiation (GO:0060291)3.21546108
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21404854
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20797983
66cellular potassium ion homeostasis (GO:0030007)3.19228680
67regulation of synaptic plasticity (GO:0048167)3.18461065
68regulation of neurotransmitter levels (GO:0001505)3.17874545
69mechanosensory behavior (GO:0007638)3.16791838
70regulation of neurotransmitter secretion (GO:0046928)3.12232896
71membrane hyperpolarization (GO:0060081)3.11671298
72neuronal ion channel clustering (GO:0045161)3.10302019
73positive regulation of synapse assembly (GO:0051965)3.09371460
74regulation of dendritic spine development (GO:0060998)3.07354677
75activation of protein kinase A activity (GO:0034199)3.06696994
76regulation of axon extension involved in axon guidance (GO:0048841)3.05913747
77startle response (GO:0001964)3.05597717
78positive regulation of dendritic spine development (GO:0060999)3.03627519
79regulation of axon guidance (GO:1902667)3.03318192
80neuromuscular process controlling balance (GO:0050885)3.01562701
81learning (GO:0007612)3.00097556
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99257820
83synapse organization (GO:0050808)2.97764814
84membrane depolarization (GO:0051899)2.96101327
85regulation of synaptic transmission, GABAergic (GO:0032228)2.95449292
86central nervous system myelination (GO:0022010)2.94734692
87axon ensheathment in central nervous system (GO:0032291)2.94734692
88regulation of vesicle fusion (GO:0031338)2.94654219
89central nervous system projection neuron axonogenesis (GO:0021952)2.94419036
90cell migration in hindbrain (GO:0021535)2.94148169
91regulation of neurotransmitter transport (GO:0051588)2.93204180
92synaptic vesicle endocytosis (GO:0048488)2.93041244
93regulation of respiratory system process (GO:0044065)2.92317190
94adult walking behavior (GO:0007628)2.92060069
95amino acid import (GO:0043090)2.91224260
96cell communication by electrical coupling (GO:0010644)2.90940047
97behavioral defense response (GO:0002209)2.89113337
98behavioral fear response (GO:0001662)2.89113337
99glycine transport (GO:0015816)2.88231827
100regulation of synapse assembly (GO:0051963)2.87787714
101positive regulation of neurotransmitter transport (GO:0051590)2.87598678
102innervation (GO:0060384)2.87427721
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87248087
104negative regulation of neurotransmitter transport (GO:0051589)2.84590642
105behavioral response to cocaine (GO:0048148)2.83746213
106axon extension (GO:0048675)2.83632533
107dendritic spine organization (GO:0097061)2.82697073
108cerebellar granule cell differentiation (GO:0021707)2.82548357
109positive regulation of neurotransmitter secretion (GO:0001956)2.82340912
110positive regulation of synaptic transmission (GO:0050806)2.81535709
111membrane depolarization during action potential (GO:0086010)2.75221754
112potassium ion homeostasis (GO:0055075)2.66444532
113nucleobase catabolic process (GO:0046113)2.65632546
114dermatan sulfate biosynthetic process (GO:0030208)2.65357600
115lymphangiogenesis (GO:0001946)2.64592347
116membrane assembly (GO:0071709)2.63170378
117negative regulation of axon extension (GO:0030517)2.62542879
118acidic amino acid transport (GO:0015800)2.61703189
119suckling behavior (GO:0001967)2.61067178
120negative regulation of axonogenesis (GO:0050771)2.59906557
121potassium ion import (GO:0010107)2.58429801
122regulation of synapse organization (GO:0050807)2.56564091
123mitochondrion transport along microtubule (GO:0047497)2.54773052
124establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.54773052
125negative regulation of axon guidance (GO:1902668)2.52524441
126regulation of voltage-gated calcium channel activity (GO:1901385)2.52494851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95532377
2GBX2_23144817_ChIP-Seq_PC3_Human3.87733509
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09484120
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06256016
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01256882
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65960064
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65960064
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.64852954
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60413978
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57335304
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52828712
12REST_21632747_ChIP-Seq_MESCs_Mouse2.45906830
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45389621
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43454531
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39595272
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.35266392
17DROSHA_22980978_ChIP-Seq_HELA_Human2.21673605
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21541095
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19312381
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.16928556
21AR_21572438_ChIP-Seq_LNCaP_Human2.13975730
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.09291143
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04384906
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99528159
25* TAF15_26573619_Chip-Seq_HEK293_Human1.98969541
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.92661221
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90625295
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89906073
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89502475
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.82848222
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78129585
32* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71824560
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62038026
34SMAD4_21799915_ChIP-Seq_A2780_Human1.60973490
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60407943
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59816896
37* CBX2_27304074_Chip-Seq_ESCs_Mouse1.58676362
38* P300_19829295_ChIP-Seq_ESCs_Human1.54585598
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52693535
40* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48753073
41* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48539938
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47743393
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47239366
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47025753
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.44151378
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43770570
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.40128990
48ZNF274_21170338_ChIP-Seq_K562_Hela1.39231714
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39107303
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38020038
51* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34128852
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.33322554
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.33152890
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32732884
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31153192
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30884905
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30482809
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29565046
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26469529
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25405528
61STAT3_23295773_ChIP-Seq_U87_Human1.25372012
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.25167567
63* RNF2_27304074_Chip-Seq_NSC_Mouse1.24938195
64AR_25329375_ChIP-Seq_VCAP_Human1.24780617
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23805447
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22830912
67* FUS_26573619_Chip-Seq_HEK293_Human1.22076746
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20476409
69* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20239116
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18634189
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.18418253
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.13018840
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12972843
74ER_23166858_ChIP-Seq_MCF-7_Human1.12855097
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12540464
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11942810
77IGF1R_20145208_ChIP-Seq_DFB_Human1.11904270
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11560181
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11560181
80AR_19668381_ChIP-Seq_PC3_Human1.11016625
81TCF4_23295773_ChIP-Seq_U87_Human1.09714271
82* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09660422
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09423294
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07893060
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07093618
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07093618
87* TP53_20018659_ChIP-ChIP_R1E_Mouse1.07069516
88AHR_22903824_ChIP-Seq_MCF-7_Human1.06987803
89* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06791382
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06613674
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.06032330
92* SOX9_26525672_Chip-Seq_HEART_Mouse1.04242856
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04100875
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03650887
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03554221
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03527169
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02343616
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02230726
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01669211
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01618246
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01541243
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01324268
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01244821
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00132347
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98837812
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98703707
107* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98491031
108JUN_21703547_ChIP-Seq_K562_Human0.97370343
109TP53_18474530_ChIP-ChIP_U2OS_Human0.97177752
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.96003924
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.93365958
112TP53_16413492_ChIP-PET_HCT116_Human0.91440617
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90459042
114BCAT_22108803_ChIP-Seq_LS180_Human0.89806437
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.89345297
116VDR_22108803_ChIP-Seq_LS180_Human0.86767257
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85913647
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.84983471
119KDM2B_26808549_Chip-Seq_REH_Human0.83221913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.57358159
2MP0003880_abnormal_central_pattern5.01298891
3MP0003635_abnormal_synaptic_transmissio3.90091515
4MP0004270_analgesia3.82017937
5MP0009745_abnormal_behavioral_response3.38626878
6MP0005423_abnormal_somatic_nervous3.29251050
7MP0002063_abnormal_learning/memory/cond3.11733451
8MP0002064_seizures3.11101119
9MP0002822_catalepsy2.94516380
10MP0009046_muscle_twitch2.88076464
11MP0001486_abnormal_startle_reflex2.80475090
12MP0002572_abnormal_emotion/affect_behav2.80309580
13MP0001968_abnormal_touch/_nociception2.70488465
14MP0002734_abnormal_mechanical_nocicepti2.63218414
15MP0002272_abnormal_nervous_system2.56409506
16MP0000778_abnormal_nervous_system2.23370985
17MP0001440_abnormal_grooming_behavior2.20435015
18MP0001501_abnormal_sleep_pattern2.02626472
19MP0002733_abnormal_thermal_nociception2.01843624
20MP0001529_abnormal_vocalization2.01207398
21MP0002736_abnormal_nociception_after1.99897070
22MP0002067_abnormal_sensory_capabilities1.93918203
23MP0002735_abnormal_chemical_nociception1.92683333
24MP0004924_abnormal_behavior1.90055961
25MP0005386_behavior/neurological_phenoty1.90055961
26MP0005646_abnormal_pituitary_gland1.89898180
27MP0001970_abnormal_pain_threshold1.89094512
28MP0002557_abnormal_social/conspecific_i1.83958625
29MP0006276_abnormal_autonomic_nervous1.83385084
30MP0003329_amyloid_beta_deposits1.81746547
31MP0002184_abnormal_innervation1.76546197
32MP0004133_heterotaxia1.74007588
33MP0010368_abnormal_lymphatic_system1.73456986
34MP0001984_abnormal_olfaction1.72720687
35MP0008569_lethality_at_weaning1.70683778
36MP0004885_abnormal_endolymph1.69319564
37MP0001905_abnormal_dopamine_level1.67376435
38MP0004858_abnormal_nervous_system1.62807442
39MP0000955_abnormal_spinal_cord1.60890528
40MP0004811_abnormal_neuron_physiology1.55364670
41MP0009780_abnormal_chondrocyte_physiolo1.55260214
42MP0005187_abnormal_penis_morphology1.55185625
43MP0005645_abnormal_hypothalamus_physiol1.53059607
44MP0002882_abnormal_neuron_morphology1.49953462
45MP0005409_darkened_coat_color1.47881851
46MP0002066_abnormal_motor_capabilities/c1.43744609
47MP0004142_abnormal_muscle_tone1.43251170
48MP0003890_abnormal_embryonic-extraembry1.39737479
49MP0001188_hyperpigmentation1.36786769
50MP0004742_abnormal_vestibular_system1.35647737
51MP0003690_abnormal_glial_cell1.34674871
52MP0001502_abnormal_circadian_rhythm1.33180606
53MP0003787_abnormal_imprinting1.30972553
54MP0001879_abnormal_lymphatic_vessel1.30095987
55MP0000920_abnormal_myelination1.29706737
56MP0002909_abnormal_adrenal_gland1.29517598
57MP0003879_abnormal_hair_cell1.25705497
58MP0003633_abnormal_nervous_system1.24491849
59MP0004272_abnormal_basement_membrane1.21510644
60MP0003634_abnormal_glial_cell1.20478392
61* MP0002152_abnormal_brain_morphology1.18354192
62MP0003119_abnormal_digestive_system1.17545312
63MP0008438_abnormal_cutaneous_collagen1.16800086
64MP0003122_maternal_imprinting1.16652805
65MP0005551_abnormal_eye_electrophysiolog1.14208825
66MP0003631_nervous_system_phenotype1.13882095
67MP0000631_abnormal_neuroendocrine_gland1.12565416
68MP0000534_abnormal_ureter_morphology1.11748193
69MP0005503_abnormal_tendon_morphology1.10917069
70MP0000049_abnormal_middle_ear1.10012810
71MP0001485_abnormal_pinna_reflex1.09155316
72MP0003279_aneurysm1.07038704
73MP0003385_abnormal_body_wall1.06070027
74MP0002229_neurodegeneration1.04907034
75MP0001963_abnormal_hearing_physiology0.98693048
76MP0009384_cardiac_valve_regurgitation0.97188165
77MP0003632_abnormal_nervous_system0.96777808
78MP0010030_abnormal_orbit_morphology0.96161673
79MP0000537_abnormal_urethra_morphology0.95958112
80MP0009250_abnormal_appendicular_skeleto0.95429899
81MP0001177_atelectasis0.92860533
82MP0003136_yellow_coat_color0.92710348
83MP0002752_abnormal_somatic_nervous0.92234094
84MP0002069_abnormal_eating/drinking_beha0.89552809
85MP0000462_abnormal_digestive_system0.88712052
86MP0003937_abnormal_limbs/digits/tail_de0.87860169
87MP0001958_emphysema0.86775594
88MP0000751_myopathy0.85250091
89MP0003121_genomic_imprinting0.85035578
90MP0005394_taste/olfaction_phenotype0.84784117
91MP0005499_abnormal_olfactory_system0.84784117
92MP0000569_abnormal_digit_pigmentation0.84605280
93MP0003942_abnormal_urinary_system0.84246389
94MP0003935_abnormal_craniofacial_develop0.81657653
95MP0008872_abnormal_physiological_respon0.81362756
96MP0001299_abnormal_eye_distance/0.80349314
97MP0008874_decreased_physiological_sensi0.79541636
98MP0002090_abnormal_vision0.77365063
99MP0003755_abnormal_palate_morphology0.76541254
100MP0000026_abnormal_inner_ear0.76333480
101MP0004145_abnormal_muscle_electrophysio0.75608696
102MP0004085_abnormal_heartbeat0.75136788
103MP0005171_absent_coat_pigmentation0.74510539
104MP0002081_perinatal_lethality0.74431013
105MP0000604_amyloidosis0.73350479
106MP0002751_abnormal_autonomic_nervous0.73309884
107MP0000428_abnormal_craniofacial_morphol0.73298730
108MP0003137_abnormal_impulse_conducting0.71948297
109MP0002638_abnormal_pupillary_reflex0.71402932
110MP0005595_abnormal_vascular_smooth0.71112441
111MP0003861_abnormal_nervous_system0.68017269
112MP0003283_abnormal_digestive_organ0.67414590
113MP0005535_abnormal_body_temperature0.67363795
114MP0003075_altered_response_to0.65270516
115MP0006072_abnormal_retinal_apoptosis0.63619225
116MP0001664_abnormal_digestion0.63167063
117MP0003938_abnormal_ear_development0.62346425
118MP0001943_abnormal_respiration0.62119515
119MP0010386_abnormal_urinary_bladder0.61464885
120MP0002102_abnormal_ear_morphology0.60343539
121MP0002653_abnormal_ependyma_morphology0.54738694
122MP0002876_abnormal_thyroid_physiology0.54441959
123MP0005253_abnormal_eye_physiology0.53618803
124MP0005623_abnormal_meninges_morphology0.52873381
125* MP0010769_abnormal_survival0.52338323
126* MP0010770_preweaning_lethality0.52230718
127* MP0002082_postnatal_lethality0.52230718
128MP0004215_abnormal_myocardial_fiber0.50618839

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.03083923
2Myokymia (HP:0002411)6.06787799
3Focal seizures (HP:0007359)5.33265620
4Epileptic encephalopathy (HP:0200134)4.67146213
5Atonic seizures (HP:0010819)4.64081714
6Visual hallucinations (HP:0002367)4.16813609
7Febrile seizures (HP:0002373)4.07520696
8Absence seizures (HP:0002121)3.90784095
9Progressive cerebellar ataxia (HP:0002073)3.88803707
10Dialeptic seizures (HP:0011146)3.63238823
11Supranuclear gaze palsy (HP:0000605)3.63161249
12Generalized tonic-clonic seizures (HP:0002069)3.59012959
13Broad-based gait (HP:0002136)3.57516275
14Action tremor (HP:0002345)3.55887425
15Hyperventilation (HP:0002883)3.47710783
16Neurofibrillary tangles (HP:0002185)3.45942802
17Ankle clonus (HP:0011448)3.36473587
18Abnormality of the corticospinal tract (HP:0002492)3.10670779
19Limb dystonia (HP:0002451)3.08230817
20Dysdiadochokinesis (HP:0002075)3.04064348
21Urinary bladder sphincter dysfunction (HP:0002839)3.03845528
22Cerebral inclusion bodies (HP:0100314)3.02136174
23Impaired vibration sensation in the lower limbs (HP:0002166)2.96383798
24Dysmetria (HP:0001310)2.95587204
25Mutism (HP:0002300)2.95569259
26Drooling (HP:0002307)2.93575123
27Excessive salivation (HP:0003781)2.93575123
28Gaze-evoked nystagmus (HP:0000640)2.90996031
29Hemiparesis (HP:0001269)2.87723325
30Abnormal eating behavior (HP:0100738)2.85429859
31Poor eye contact (HP:0000817)2.85164462
32Termporal pattern (HP:0011008)2.82422959
33Insidious onset (HP:0003587)2.82422959
34Megalencephaly (HP:0001355)2.82242077
35Spastic gait (HP:0002064)2.81485214
36Truncal ataxia (HP:0002078)2.81351197
37Aplasia involving bones of the upper limbs (HP:0009823)2.78518337
38Aplasia of the phalanges of the hand (HP:0009802)2.78518337
39Aplasia involving bones of the extremities (HP:0009825)2.78518337
40Anxiety (HP:0000739)2.76723742
41Progressive inability to walk (HP:0002505)2.75678453
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.74183662
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.74183662
44Postural instability (HP:0002172)2.74059971
45Depression (HP:0000716)2.72747893
46Pheochromocytoma (HP:0002666)2.66980407
47Abnormality of binocular vision (HP:0011514)2.65802996
48Diplopia (HP:0000651)2.65802996
49Impaired social interactions (HP:0000735)2.55969017
50Abnormal social behavior (HP:0012433)2.55969017
51Polyphagia (HP:0002591)2.52490437
52Amblyopia (HP:0000646)2.52170942
53Urinary urgency (HP:0000012)2.47938017
54Papilledema (HP:0001085)2.46000039
55Akinesia (HP:0002304)2.45206189
56Lower limb muscle weakness (HP:0007340)2.43722570
57Intention tremor (HP:0002080)2.42722026
58Absent speech (HP:0001344)2.37532429
59Neuroendocrine neoplasm (HP:0100634)2.36694446
60Fetal akinesia sequence (HP:0001989)2.35474553
61Torticollis (HP:0000473)2.35440903
62Genetic anticipation (HP:0003743)2.34920141
63Scanning speech (HP:0002168)2.29902627
64Blue irides (HP:0000635)2.29258353
65Broad metatarsal (HP:0001783)2.23190761
66Peripheral hypomyelination (HP:0007182)2.22371091
67Premature rupture of membranes (HP:0001788)2.22036760
68Bradykinesia (HP:0002067)2.20042773
69Epileptiform EEG discharges (HP:0011182)2.19313608
70Generalized myoclonic seizures (HP:0002123)2.15999193
71EEG with generalized epileptiform discharges (HP:0011198)2.13388720
72Inability to walk (HP:0002540)2.13337147
73Stereotypic behavior (HP:0000733)2.12983826
74Hemiplegia (HP:0002301)2.11339253
75Focal dystonia (HP:0004373)2.09627606
76Absent/shortened dynein arms (HP:0200106)2.07482906
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.07482906
78Abnormality of salivation (HP:0100755)2.04509100
79Hypsarrhythmia (HP:0002521)2.04220739
80Shallow orbits (HP:0000586)2.01752028
81Overgrowth (HP:0001548)2.00795433
82Gait imbalance (HP:0002141)1.99955025
83Impaired vibratory sensation (HP:0002495)1.98777674
84Agitation (HP:0000713)1.95641821
85Clumsiness (HP:0002312)1.95368664
86Craniofacial dystonia (HP:0012179)1.92641382
87Impaired smooth pursuit (HP:0007772)1.91282814
88Status epilepticus (HP:0002133)1.89243556
89Sleep apnea (HP:0010535)1.85448999
90Arterial tortuosity (HP:0005116)1.82715120
91Vascular tortuosity (HP:0004948)1.82021339
92Morphological abnormality of the pyramidal tract (HP:0002062)1.81319573
93Specific learning disability (HP:0001328)1.81142292
94Retinal dysplasia (HP:0007973)1.80321815
95Pulmonic stenosis (HP:0001642)1.79851243
96Cortical dysplasia (HP:0002539)1.78894508
97Shawl scrotum (HP:0000049)1.78512829
98Abnormal ciliary motility (HP:0012262)1.77055348
99Protrusio acetabuli (HP:0003179)1.75757601
100Soft skin (HP:0000977)1.75146483
101Neuronal loss in central nervous system (HP:0002529)1.75079449
102Coronal craniosynostosis (HP:0004440)1.74791020
103Abnormality of ocular smooth pursuit (HP:0000617)1.73889213
104Hypoventilation (HP:0002791)1.73578004
105Psychosis (HP:0000709)1.72831245
106Split foot (HP:0001839)1.72731413
107Neonatal short-limb short stature (HP:0008921)1.72594327
108Abnormality of the ischium (HP:0003174)1.72562239
109Incomplete penetrance (HP:0003829)1.71585252
110Bowel diverticulosis (HP:0005222)1.71484093
111Gait ataxia (HP:0002066)1.71399735
112Aqueductal stenosis (HP:0002410)1.71119609
113Cutaneous finger syndactyly (HP:0010554)1.71029029
114Protruding tongue (HP:0010808)1.70891768
115Clonus (HP:0002169)1.70808267
116Narrow nasal bridge (HP:0000446)1.70383356
117Thickened helices (HP:0000391)1.69736263
118Aortic dissection (HP:0002647)1.69624120
119Inappropriate behavior (HP:0000719)1.69332710
120Bowel incontinence (HP:0002607)1.68466170
121Neoplasm of the peripheral nervous system (HP:0100007)1.67962065
122Hammertoe (HP:0001765)1.67581291
123Amyotrophic lateral sclerosis (HP:0007354)1.66238998
124Congenital primary aphakia (HP:0007707)1.63600770
125Abnormality of dentin (HP:0010299)1.60708877
126Spastic tetraplegia (HP:0002510)1.59978649
127Vaginal atresia (HP:0000148)1.59800612
128Vitreoretinal degeneration (HP:0000655)1.59748238
129Bladder diverticulum (HP:0000015)1.59319758
130Wide anterior fontanel (HP:0000260)1.58874340
131Genital tract atresia (HP:0001827)1.58670808
132Nephrogenic diabetes insipidus (HP:0009806)1.57994102
133Short 4th metacarpal (HP:0010044)1.57047712
134Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.57047712
135Myotonia (HP:0002486)1.56413934
136Hypoplasia of the iris (HP:0007676)1.56157644
137Obstructive sleep apnea (HP:0002870)1.55683901
138Infantile muscular hypotonia (HP:0008947)1.55570163
139Abnormality of the lower motor neuron (HP:0002366)1.55505000
140Esotropia (HP:0000565)1.54795852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.19188922
2MARK13.93824687
3NTRK33.76570048
4TNIK3.57378840
5CASK2.97188871
6MAP3K42.90380579
7MAP3K92.83624463
8NTRK22.64851295
9MAP2K72.53682840
10TIE12.34525486
11MINK12.25692427
12PAK62.02091575
13DAPK21.96422802
14AKT31.90689358
15NTRK11.86097587
16MAPK131.76767120
17PNCK1.74960420
18EPHB21.55893095
19CDK51.53363543
20MAP2K41.51453932
21MAP3K121.46041635
22CDK191.40408779
23PHKG21.38286400
24PHKG11.38286400
25PLK21.36786221
26RIPK41.36457427
27KSR21.36431104
28OXSR11.36326510
29PINK11.36009963
30SIK21.34784783
31PRKD31.34559370
32KSR11.32884316
33STK391.27509255
34UHMK11.26709479
35CAMKK11.23941622
36GRK51.22609349
37PRKCG1.19996234
38FES1.15980404
39PRPF4B1.11200517
40TYRO31.09179959
41CAMK2A1.06167994
42CSNK1G21.01341763
43LIMK10.99063087
44PAK30.97440933
45SGK4940.95050631
46SGK2230.95050631
47DAPK10.91330334
48CDK180.90949358
49CDK150.90684431
50CDK140.89724675
51STK110.89270676
52CAMK2B0.88542715
53NEK60.86143504
54BMPR1B0.84985486
55MAP3K20.82179244
56ERBB40.82044663
57GRK70.81705970
58CDK11A0.80677658
59LATS20.80585153
60MUSK0.79448823
61CAMKK20.79319866
62FGR0.78769562
63MKNK20.78411982
64MARK20.78041712
65PKN10.77814471
66PDGFRA0.76216196
67FGFR20.76098499
68PAK20.74943405
69TAOK10.73976785
70DYRK1A0.72525304
71CAMK1G0.72463109
72CAMK10.71153639
73PRKCE0.70471358
74SGK10.70241815
75ARAF0.69284960
76BCR0.68264130
77PTK20.67961453
78SGK20.66887888
79RET0.66787127
80BMPR20.66748115
81ROCK10.65526559
82WNK30.65389086
83STK380.64995046
84CSNK1G30.62812580
85PRKCH0.62430126
86WNK40.62126837
87LMTK20.58864153
88MAP3K130.57480929
89CAMK2D0.55873979
90ROCK20.54515506
91WNK10.54503206
92TRIM280.54130622
93MAPK150.53474338
94FYN0.52014531
95TNK20.50466611
96PRKCZ0.49498083
97ADRBK10.48403111
98RAF10.48179569
99CAMK2G0.47676732
100RPS6KA30.47447268
101SGK30.47005465
102CSNK1A1L0.46877316
103MAPKAPK50.45976195
104TSSK60.45929022
105DDR20.44590696
106ADRBK20.44099287
107DYRK20.44022754
108EPHA30.43588778
109CAMK40.43495332
110PDPK10.43174743
111MAPK120.43058377
112ERBB30.42570022
113MAPK100.40909994
114CSNK1G10.40433073
115PTK2B0.39872766
116MAP3K60.39666873
117RPS6KA20.39164106
118RIPK10.37567495
119PDK10.37175942
120PRKG10.36317815
121BRD40.35122796
122CSNK1D0.34079779
123MAP4K20.29091924
124PDGFRB0.27151383

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.89873901
2Synaptic vesicle cycle_Homo sapiens_hsa047212.96104259
3GABAergic synapse_Homo sapiens_hsa047272.89461573
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74270989
5Glutamatergic synapse_Homo sapiens_hsa047242.73143801
6Olfactory transduction_Homo sapiens_hsa047402.66219392
7Morphine addiction_Homo sapiens_hsa050322.62797050
8Circadian entrainment_Homo sapiens_hsa047132.58352003
9Long-term potentiation_Homo sapiens_hsa047202.30438573
10Amphetamine addiction_Homo sapiens_hsa050312.28534287
11Dopaminergic synapse_Homo sapiens_hsa047282.13782015
12Salivary secretion_Homo sapiens_hsa049702.10887463
13Serotonergic synapse_Homo sapiens_hsa047261.92732588
14Cholinergic synapse_Homo sapiens_hsa047251.91085103
15Cocaine addiction_Homo sapiens_hsa050301.90279711
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88728114
17Insulin secretion_Homo sapiens_hsa049111.82207690
18Gastric acid secretion_Homo sapiens_hsa049711.80415671
19Taste transduction_Homo sapiens_hsa047421.77633804
20Long-term depression_Homo sapiens_hsa047301.74415947
21Renin secretion_Homo sapiens_hsa049241.67382108
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56552936
23Axon guidance_Homo sapiens_hsa043601.54464115
24Calcium signaling pathway_Homo sapiens_hsa040201.53324801
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52984748
26Oxytocin signaling pathway_Homo sapiens_hsa049211.49632262
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39538787
28Gap junction_Homo sapiens_hsa045401.38912508
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36178910
30Collecting duct acid secretion_Homo sapiens_hsa049661.33987158
31GnRH signaling pathway_Homo sapiens_hsa049121.33492636
32Hippo signaling pathway_Homo sapiens_hsa043901.33032263
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22456454
34cAMP signaling pathway_Homo sapiens_hsa040241.20710604
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12314978
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11091862
37Cardiac muscle contraction_Homo sapiens_hsa042601.10883717
38ErbB signaling pathway_Homo sapiens_hsa040121.07748882
39Melanogenesis_Homo sapiens_hsa049161.03686419
40Phototransduction_Homo sapiens_hsa047441.02945882
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02318419
42Estrogen signaling pathway_Homo sapiens_hsa049151.01966555
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99741374
44Dorso-ventral axis formation_Homo sapiens_hsa043200.99050969
45Basal cell carcinoma_Homo sapiens_hsa052170.96981286
46Glioma_Homo sapiens_hsa052140.96595944
47Nitrogen metabolism_Homo sapiens_hsa009100.94300320
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.93098007
49Type II diabetes mellitus_Homo sapiens_hsa049300.92875889
50ECM-receptor interaction_Homo sapiens_hsa045120.91725029
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90774645
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89409542
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87504471
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.87065473
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86469203
56Vibrio cholerae infection_Homo sapiens_hsa051100.85244409
57TGF-beta signaling pathway_Homo sapiens_hsa043500.83922282
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83295254
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82360662
60Dilated cardiomyopathy_Homo sapiens_hsa054140.81222336
61Pancreatic secretion_Homo sapiens_hsa049720.80151565
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75746672
63Tight junction_Homo sapiens_hsa045300.75259212
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74441309
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71297494
66Focal adhesion_Homo sapiens_hsa045100.70700905
67MAPK signaling pathway_Homo sapiens_hsa040100.70123567
68Choline metabolism in cancer_Homo sapiens_hsa052310.69462057
69Vitamin B6 metabolism_Homo sapiens_hsa007500.69419160
70Ras signaling pathway_Homo sapiens_hsa040140.69254306
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68602652
72Thyroid hormone synthesis_Homo sapiens_hsa049180.67907747
73Protein digestion and absorption_Homo sapiens_hsa049740.66863889
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63870931
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63839349
76Oocyte meiosis_Homo sapiens_hsa041140.63632450
77Alzheimers disease_Homo sapiens_hsa050100.63614979
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.63129734
79Adherens junction_Homo sapiens_hsa045200.63037831
80Alcoholism_Homo sapiens_hsa050340.61873802
81Melanoma_Homo sapiens_hsa052180.57125294
82Oxidative phosphorylation_Homo sapiens_hsa001900.54546746
83Renal cell carcinoma_Homo sapiens_hsa052110.53191893
84Ovarian steroidogenesis_Homo sapiens_hsa049130.52974502
85Rap1 signaling pathway_Homo sapiens_hsa040150.52741135
86Wnt signaling pathway_Homo sapiens_hsa043100.51789976
87Ether lipid metabolism_Homo sapiens_hsa005650.50904116
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50901062
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50706440
90African trypanosomiasis_Homo sapiens_hsa051430.49366380
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49215926
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46200510
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44917174
94Butanoate metabolism_Homo sapiens_hsa006500.44862065
95Parkinsons disease_Homo sapiens_hsa050120.44249312
96Type I diabetes mellitus_Homo sapiens_hsa049400.43424956
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43242210
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43204979
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42528565
100Colorectal cancer_Homo sapiens_hsa052100.42088091
101Fatty acid biosynthesis_Homo sapiens_hsa000610.42064024
102Bile secretion_Homo sapiens_hsa049760.42025367
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41134010
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41050532
105Endocytosis_Homo sapiens_hsa041440.40958659
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40839568
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.40127447
108Prion diseases_Homo sapiens_hsa050200.39766796
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39466574
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37970187
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36967869
112VEGF signaling pathway_Homo sapiens_hsa043700.35840338
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35134041
114Hedgehog signaling pathway_Homo sapiens_hsa043400.34813910
115Inositol phosphate metabolism_Homo sapiens_hsa005620.34609492
116Glucagon signaling pathway_Homo sapiens_hsa049220.34508933
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.34416864
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33623319
119Chemokine signaling pathway_Homo sapiens_hsa040620.32974585
120Circadian rhythm_Homo sapiens_hsa047100.31494634

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