PCDH11X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.42558059
2presynaptic membrane assembly (GO:0097105)5.13763031
3vocalization behavior (GO:0071625)4.89583079
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83637156
5presynaptic membrane organization (GO:0097090)4.73574381
6neuron recognition (GO:0008038)4.58007280
7locomotory exploration behavior (GO:0035641)4.56992767
8postsynaptic membrane organization (GO:0001941)4.50924611
9dendritic spine morphogenesis (GO:0060997)4.48946932
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.43837174
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41752385
12protein localization to synapse (GO:0035418)4.32901987
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.30207304
14regulation of glutamate receptor signaling pathway (GO:1900449)4.09452909
15transmission of nerve impulse (GO:0019226)4.07367848
16negative regulation of synaptic transmission, GABAergic (GO:0032229)4.02169757
17axonal fasciculation (GO:0007413)3.97335814
18glutamate receptor signaling pathway (GO:0007215)3.96221788
19exploration behavior (GO:0035640)3.95253482
20axon ensheathment in central nervous system (GO:0032291)3.95139276
21central nervous system myelination (GO:0022010)3.95139276
22pyrimidine nucleobase catabolic process (GO:0006208)3.93007649
23regulation of synaptic vesicle exocytosis (GO:2000300)3.92571838
24positive regulation of synapse assembly (GO:0051965)3.90843329
25piRNA metabolic process (GO:0034587)3.88802451
26behavioral response to nicotine (GO:0035095)3.86692624
27layer formation in cerebral cortex (GO:0021819)3.83525558
28synaptic vesicle exocytosis (GO:0016079)3.82181274
29neurotransmitter-gated ion channel clustering (GO:0072578)3.81913404
30synaptic transmission, glutamatergic (GO:0035249)3.77207925
31glutamate secretion (GO:0014047)3.74589229
32synaptic vesicle maturation (GO:0016188)3.69978794
33negative regulation of telomere maintenance (GO:0032205)3.66244183
34dendrite morphogenesis (GO:0048813)3.65681351
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59700068
36gamma-aminobutyric acid transport (GO:0015812)3.58132394
37neuron-neuron synaptic transmission (GO:0007270)3.56463390
38L-fucose catabolic process (GO:0042355)3.55506375
39fucose catabolic process (GO:0019317)3.55506375
40L-fucose metabolic process (GO:0042354)3.55506375
41regulation of DNA methylation (GO:0044030)3.55153941
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.53838839
43retinal cone cell development (GO:0046549)3.53693087
44negative regulation of neurotransmitter transport (GO:0051589)3.47376641
45neuronal action potential propagation (GO:0019227)3.45852713
46auditory behavior (GO:0031223)3.45245653
47negative regulation of neurotransmitter secretion (GO:0046929)3.44961960
48cerebral cortex radially oriented cell migration (GO:0021799)3.44711545
49long-chain fatty acid biosynthetic process (GO:0042759)3.43978065
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43543961
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.42887743
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.42887743
53regulation of translation, ncRNA-mediated (GO:0045974)3.42887743
54regulation of synaptic vesicle transport (GO:1902803)3.41295179
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40558573
56establishment of mitochondrion localization (GO:0051654)3.38662658
57regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.36613075
58regulation of meiosis I (GO:0060631)3.32654496
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31309120
60DNA methylation involved in gamete generation (GO:0043046)3.30248476
61proline transport (GO:0015824)3.29044778
62regulation of helicase activity (GO:0051095)3.28841080
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27077104
64startle response (GO:0001964)3.25639964
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25556831
66neurotransmitter secretion (GO:0007269)3.20479085
67behavioral response to ethanol (GO:0048149)3.18980642
68synapse assembly (GO:0007416)3.18468390
69central nervous system projection neuron axonogenesis (GO:0021952)3.18035416
70regulation of synapse assembly (GO:0051963)3.14776794
71cell migration in hindbrain (GO:0021535)3.14319381
72cerebellar granule cell differentiation (GO:0021707)3.14131920
73nucleobase catabolic process (GO:0046113)3.14101481
74dendrite development (GO:0016358)3.13017316
75neuronal action potential (GO:0019228)3.11284513
76regulation of telomere maintenance via telomerase (GO:0032210)3.10542878
77L-amino acid import (GO:0043092)3.10161123
78regulation of synapse structural plasticity (GO:0051823)3.09224912
79regulation of neuronal synaptic plasticity (GO:0048168)3.08916364
80regulation of axon regeneration (GO:0048679)3.08500291
81regulation of neuron projection regeneration (GO:0070570)3.08500291
82regulation of telomere maintenance (GO:0032204)3.07679996
83regulation of nuclear cell cycle DNA replication (GO:0033262)3.07400122
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06566584
85positive regulation of membrane potential (GO:0045838)3.04533086
86response to auditory stimulus (GO:0010996)3.03983319
87regulation of acrosome reaction (GO:0060046)3.03937724
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02848858
89regulation of mitotic spindle checkpoint (GO:1903504)3.02848858
90regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02676390
91response to histamine (GO:0034776)3.01534738
92mechanosensory behavior (GO:0007638)2.98793543
93regulation of synaptic transmission, glutamatergic (GO:0051966)2.97623157
94synapse organization (GO:0050808)2.97242151
95centriole replication (GO:0007099)2.96758877
96regulation of dendritic spine morphogenesis (GO:0061001)2.96680927
97amino acid import (GO:0043090)2.96466520
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96122136
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95555941
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94912492
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94576604
102protein localization to cilium (GO:0061512)2.94245596
103regulation of respiratory system process (GO:0044065)2.93117586
104regulation of synaptic transmission, GABAergic (GO:0032228)2.92913069
105multicellular organism reproduction (GO:0032504)2.92817717
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91464753
107regulation of postsynaptic membrane potential (GO:0060078)2.91368009
108long-term memory (GO:0007616)2.90352007
109long-term synaptic potentiation (GO:0060291)2.88466571
110detection of light stimulus involved in visual perception (GO:0050908)2.87062716
111detection of light stimulus involved in sensory perception (GO:0050962)2.87062716
112neurotransmitter transport (GO:0006836)2.86938832
113positive regulation of dendritic spine development (GO:0060999)2.86786098
114neuronal ion channel clustering (GO:0045161)2.85800293
115membrane assembly (GO:0071709)2.85367167
116positive regulation of action potential (GO:0045760)2.82235112
117regulation of dendritic spine development (GO:0060998)2.80998734
118response to pheromone (GO:0019236)2.79992220
119myelination (GO:0042552)2.79859863
120membrane hyperpolarization (GO:0060081)2.78795413
121regulation of glutamate secretion (GO:0014048)2.78403630
122regulation of vesicle fusion (GO:0031338)2.78070698
123epithelial cilium movement (GO:0003351)2.77703506
124fatty acid elongation (GO:0030497)2.76416661
125establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75367775
126mitochondrion transport along microtubule (GO:0047497)2.75367775
127DNA double-strand break processing (GO:0000729)2.75211159
128adult walking behavior (GO:0007628)2.74937383
129apical protein localization (GO:0045176)2.73787813
130regulation of synapse organization (GO:0050807)2.73688148
131learning (GO:0007612)2.72502847
132axon ensheathment (GO:0008366)2.71907149
133ensheathment of neurons (GO:0007272)2.71907149
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.71818586
135DNA damage response, detection of DNA damage (GO:0042769)2.71230285
136oligodendrocyte differentiation (GO:0048709)2.70047812
137protein polyglutamylation (GO:0018095)2.69197282
138DNA damage induced protein phosphorylation (GO:0006975)2.68804203
139limb bud formation (GO:0060174)2.68048811
140regulation of action potential (GO:0098900)2.67860013
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67815988
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.66493664
143replication fork processing (GO:0031297)2.65172945
144nonmotile primary cilium assembly (GO:0035058)2.61860012
145chromatin remodeling at centromere (GO:0031055)2.60197831
146neural tube formation (GO:0001841)2.58265875
147telomere maintenance via telomerase (GO:0007004)2.56182595
148single strand break repair (GO:0000012)2.51745021
149meiotic cell cycle (GO:0051321)2.50526835
150regulation of feeding behavior (GO:0060259)2.50476796
151cilium morphogenesis (GO:0060271)2.49430335
152male meiosis (GO:0007140)2.48645169
153olfactory bulb development (GO:0021772)2.47346142
154kidney morphogenesis (GO:0060993)2.45978481
155water-soluble vitamin biosynthetic process (GO:0042364)2.45176708
156gene silencing by RNA (GO:0031047)2.43517059
157glycerophospholipid catabolic process (GO:0046475)2.42666145
158photoreceptor cell development (GO:0042461)2.42409994
159CENP-A containing nucleosome assembly (GO:0034080)2.40750636
160reciprocal meiotic recombination (GO:0007131)2.39149316
161reciprocal DNA recombination (GO:0035825)2.39149316
162male meiosis I (GO:0007141)2.37681169
163sympathetic nervous system development (GO:0048485)2.37291915
164regulation of collateral sprouting (GO:0048670)2.36802156
165synapsis (GO:0007129)2.34143664
166reflex (GO:0060004)2.32825585
167regulation of calcium ion-dependent exocytosis (GO:0017158)2.30583805
168somite development (GO:0061053)2.29649281
169kynurenine metabolic process (GO:0070189)2.29494708
170central nervous system neuron axonogenesis (GO:0021955)2.29424535
171intraciliary transport (GO:0042073)2.26623432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16103275
2GBX2_23144817_ChIP-Seq_PC3_Human4.11570458
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99291481
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97548966
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85147396
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.68302531
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56835897
8AR_21572438_ChIP-Seq_LNCaP_Human2.54440445
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52542697
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.52346393
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48686868
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47281687
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47281687
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.46388670
15* TAF15_26573619_Chip-Seq_HEK293_Human2.45071691
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42410658
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40092032
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29019058
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24178217
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23345893
21REST_21632747_ChIP-Seq_MESCs_Mouse2.17927332
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17585401
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16323397
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.15402074
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13755740
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06919895
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.06866924
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01952575
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00674022
30* CBX2_27304074_Chip-Seq_ESCs_Mouse1.98068501
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88002062
32DROSHA_22980978_ChIP-Seq_HELA_Human1.85144665
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79314979
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78519491
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77835798
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77130392
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77118928
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75458085
39* P300_19829295_ChIP-Seq_ESCs_Human1.73180470
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70011935
41IRF1_19129219_ChIP-ChIP_H3396_Human1.68197211
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68134783
43FUS_26573619_Chip-Seq_HEK293_Human1.65537446
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64995840
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.64648659
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63006376
47SMAD4_21799915_ChIP-Seq_A2780_Human1.61296136
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.61094046
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.57180390
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55160006
51* RNF2_27304074_Chip-Seq_NSC_Mouse1.54989980
52ZNF274_21170338_ChIP-Seq_K562_Hela1.53802900
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.53120706
54* RARB_27405468_Chip-Seq_BRAIN_Mouse1.51727572
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51140960
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50640494
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49656825
58CBP_20019798_ChIP-Seq_JUKART_Human1.48907501
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48907501
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45680731
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45400935
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44013041
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40924882
64ER_23166858_ChIP-Seq_MCF-7_Human1.40718483
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38855555
66TP53_22573176_ChIP-Seq_HFKS_Human1.37869079
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35613488
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32653750
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.30349634
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30251897
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.30073899
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.29319826
73IGF1R_20145208_ChIP-Seq_DFB_Human1.26971257
74STAT3_23295773_ChIP-Seq_U87_Human1.26962339
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26586741
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26323454
77* BCAT_22108803_ChIP-Seq_LS180_Human1.26311269
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26082124
79MYC_18940864_ChIP-ChIP_HL60_Human1.23561814
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22646105
81AR_25329375_ChIP-Seq_VCAP_Human1.21845554
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21237049
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19272019
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18437595
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17771163
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.17297579
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15957236
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.15425956
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.15389605
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15362160
91* TCF4_22108803_ChIP-Seq_LS180_Human1.15256563
92TCF4_23295773_ChIP-Seq_U87_Human1.15055183
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.14877318
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13602798
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.13424010
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12515820
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12400251
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11897799
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11048804
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.10487714
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08587874
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08002367
103NANOG_19829295_ChIP-Seq_ESCs_Human1.07884615
104SOX2_19829295_ChIP-Seq_ESCs_Human1.07884615
105AHR_22903824_ChIP-Seq_MCF-7_Human1.07797704
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07730930
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.06077951
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.05495548
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03943153
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.03159301
111TP53_18474530_ChIP-ChIP_U2OS_Human1.03071869
112JUN_21703547_ChIP-Seq_K562_Human1.03032950
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.02855160
114VDR_22108803_ChIP-Seq_LS180_Human1.01702642
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01483808
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01052301
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01052301
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00447117
119* AR_19668381_ChIP-Seq_PC3_Human0.99580640
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98667353
121EWS_26573619_Chip-Seq_HEK293_Human0.98070149
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97974444
123FLI1_21867929_ChIP-Seq_TH2_Mouse0.97662287
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96424417
125GABP_17652178_ChIP-ChIP_JURKAT_Human0.96159737
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95620356
127NCOR_22424771_ChIP-Seq_293T_Human0.95467234
128KDM2B_26808549_Chip-Seq_REH_Human0.94846282
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94785690
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93490151
131* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93395856
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.92726031
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.92577095
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.92260581
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92123911
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92106486
137TP53_16413492_ChIP-PET_HCT116_Human0.91163154
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89017092
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88934324
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87190924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.89337051
2MP0004859_abnormal_synaptic_plasticity4.21261265
3MP0003635_abnormal_synaptic_transmissio3.42608273
4MP0008877_abnormal_DNA_methylation3.39450357
5MP0004270_analgesia3.36896675
6MP0009745_abnormal_behavioral_response2.92128676
7MP0001968_abnormal_touch/_nociception2.86668248
8MP0001486_abnormal_startle_reflex2.80607341
9MP0005423_abnormal_somatic_nervous2.75623601
10MP0002063_abnormal_learning/memory/cond2.75161107
11MP0002064_seizures2.74610025
12MP0000778_abnormal_nervous_system2.69548489
13MP0009046_muscle_twitch2.59322714
14MP0005645_abnormal_hypothalamus_physiol2.55772001
15MP0002572_abnormal_emotion/affect_behav2.52191199
16MP0002736_abnormal_nociception_after2.51745065
17MP0003718_maternal_effect2.50171241
18MP0002734_abnormal_mechanical_nocicepti2.46375036
19MP0002272_abnormal_nervous_system2.39647518
20MP0001529_abnormal_vocalization2.38553656
21MP0001440_abnormal_grooming_behavior2.17723536
22MP0006276_abnormal_autonomic_nervous2.16496085
23MP0003136_yellow_coat_color2.03227947
24MP0002067_abnormal_sensory_capabilities2.01653195
25MP0003122_maternal_imprinting2.00980353
26MP0004133_heterotaxia1.99262643
27MP0002557_abnormal_social/conspecific_i1.97513123
28MP0002733_abnormal_thermal_nociception1.95901323
29MP0004142_abnormal_muscle_tone1.93785087
30MP0002184_abnormal_innervation1.93197964
31MP0005386_behavior/neurological_phenoty1.90490216
32MP0004924_abnormal_behavior1.90490216
33MP0002735_abnormal_chemical_nociception1.87796443
34MP0005646_abnormal_pituitary_gland1.87636025
35MP0001970_abnormal_pain_threshold1.81968116
36MP0001986_abnormal_taste_sensitivity1.81454656
37MP0004885_abnormal_endolymph1.79780854
38MP0000920_abnormal_myelination1.76586270
39MP0003890_abnormal_embryonic-extraembry1.74674053
40MP0004742_abnormal_vestibular_system1.71212657
41MP0003329_amyloid_beta_deposits1.68258954
42MP0001905_abnormal_dopamine_level1.67151386
43MP0001501_abnormal_sleep_pattern1.64122818
44MP0001984_abnormal_olfaction1.62606813
45MP0000955_abnormal_spinal_cord1.59773591
46MP0002234_abnormal_pharynx_morphology1.57931499
47MP0005171_absent_coat_pigmentation1.57178510
48MP0002882_abnormal_neuron_morphology1.54288351
49MP0002066_abnormal_motor_capabilities/c1.45610622
50MP0003690_abnormal_glial_cell1.44785445
51MP0005409_darkened_coat_color1.40855184
52MP0008058_abnormal_DNA_repair1.39565269
53MP0008569_lethality_at_weaning1.39238185
54MP0004811_abnormal_neuron_physiology1.38364246
55MP0003634_abnormal_glial_cell1.38216876
56MP0008057_abnormal_DNA_replication1.37097527
57MP0001502_abnormal_circadian_rhythm1.36308566
58MP0003119_abnormal_digestive_system1.35744422
59MP0003195_calcinosis1.34868045
60MP0001188_hyperpigmentation1.33853163
61MP0001293_anophthalmia1.30647551
62MP0000427_abnormal_hair_cycle1.30315797
63MP0000569_abnormal_digit_pigmentation1.29341538
64MP0000631_abnormal_neuroendocrine_gland1.28495601
65MP0002152_abnormal_brain_morphology1.24229822
66MP0009780_abnormal_chondrocyte_physiolo1.22436010
67MP0001963_abnormal_hearing_physiology1.22309301
68MP0003693_abnormal_embryo_hatching1.21900758
69MP0005174_abnormal_tail_pigmentation1.15123282
70MP0001485_abnormal_pinna_reflex1.14625275
71MP0005253_abnormal_eye_physiology1.14048177
72MP0002653_abnormal_ependyma_morphology1.13846032
73MP0000566_synostosis1.12320275
74MP0005551_abnormal_eye_electrophysiolog1.10423466
75MP0002752_abnormal_somatic_nervous1.10293980
76MP0002229_neurodegeneration1.06406352
77MP0000026_abnormal_inner_ear1.05902366
78MP0002160_abnormal_reproductive_system1.04776280
79MP0004858_abnormal_nervous_system1.03455876
80MP0004147_increased_porphyrin_level1.01369008
81MP0008875_abnormal_xenobiotic_pharmacok1.00659700
82MP0001299_abnormal_eye_distance/1.00630133
83MP0004043_abnormal_pH_regulation1.00602463
84MP0002822_catalepsy0.99872464
85MP0000647_abnormal_sebaceous_gland0.98668479
86MP0001929_abnormal_gametogenesis0.97692324
87MP0002210_abnormal_sex_determination0.97455964
88MP0004134_abnormal_chest_morphology0.95916421
89MP0003632_abnormal_nervous_system0.95679729
90MP0003631_nervous_system_phenotype0.94067998
91MP0003938_abnormal_ear_development0.93935667
92MP0000462_abnormal_digestive_system0.93526907
93MP0005395_other_phenotype0.92259510
94MP0002102_abnormal_ear_morphology0.91505510
95MP0003698_abnormal_male_reproductive0.91122747
96MP0003633_abnormal_nervous_system0.90221185
97MP0002233_abnormal_nose_morphology0.87942947
98MP0000653_abnormal_sex_gland0.86403118
99MP0002069_abnormal_eating/drinking_beha0.85246618
100MP0003861_abnormal_nervous_system0.85076456
101MP0002909_abnormal_adrenal_gland0.83942491
102MP0001324_abnormal_eye_pigmentation0.83801478
103MP0005499_abnormal_olfactory_system0.83492933
104MP0005394_taste/olfaction_phenotype0.83492933
105MP0000383_abnormal_hair_follicle0.83150447
106MP0003385_abnormal_body_wall0.82178012
107MP0005410_abnormal_fertilization0.82112902
108MP0003937_abnormal_limbs/digits/tail_de0.80105933
109MP0009250_abnormal_appendicular_skeleto0.79428214
110MP0001177_atelectasis0.79104255
111MP0006072_abnormal_retinal_apoptosis0.78228772
112MP0003567_abnormal_fetal_cardiomyocyte0.77990103
113MP0002751_abnormal_autonomic_nervous0.77636102
114MP0005389_reproductive_system_phenotype0.77570831
115MP0005187_abnormal_penis_morphology0.77278028
116MP0003121_genomic_imprinting0.76483181
117MP0001943_abnormal_respiration0.75454594
118MP0000751_myopathy0.74873834
119MP0004085_abnormal_heartbeat0.73073724
120MP0003879_abnormal_hair_cell0.71830242
121MP0004145_abnormal_muscle_electrophysio0.71811485
122MP0009379_abnormal_foot_pigmentation0.69526358
123MP0006292_abnormal_olfactory_placode0.66945959
124MP0002876_abnormal_thyroid_physiology0.66043040
125MP0002638_abnormal_pupillary_reflex0.64839392
126MP0008872_abnormal_physiological_respon0.63369821
127MP0003137_abnormal_impulse_conducting0.63337082
128MP0000604_amyloidosis0.62538011
129MP0002938_white_spotting0.61163226
130MP0008789_abnormal_olfactory_epithelium0.60667747
131MP0000534_abnormal_ureter_morphology0.60503706
132MP0005195_abnormal_posterior_eye0.60170038
133MP0010770_preweaning_lethality0.58230455
134MP0002082_postnatal_lethality0.58230455
135MP0005535_abnormal_body_temperature0.58085400
136MP0003787_abnormal_imprinting0.57501316

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.12714355
2Septo-optic dysplasia (HP:0100842)4.68432881
3Myokymia (HP:0002411)4.35359399
4Focal seizures (HP:0007359)4.05300260
5Abnormality of the corticospinal tract (HP:0002492)4.02065647
6Epileptic encephalopathy (HP:0200134)3.99874395
7Pancreatic cysts (HP:0001737)3.73384189
8Neurofibrillary tangles (HP:0002185)3.71121462
9Abnormality of midbrain morphology (HP:0002418)3.68441969
10Molar tooth sign on MRI (HP:0002419)3.68441969
11Atonic seizures (HP:0010819)3.64407223
12Polyphagia (HP:0002591)3.63992410
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.55677409
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.55677409
15Pancreatic fibrosis (HP:0100732)3.54732553
16Broad-based gait (HP:0002136)3.54038719
17Supranuclear gaze palsy (HP:0000605)3.38810239
18Visual hallucinations (HP:0002367)3.38469546
19Progressive cerebellar ataxia (HP:0002073)3.27675451
20Optic nerve hypoplasia (HP:0000609)3.26475431
21Mutism (HP:0002300)3.23266182
22Hyperventilation (HP:0002883)3.14722968
23Nephronophthisis (HP:0000090)3.13767803
24True hermaphroditism (HP:0010459)3.10308218
25Cerebral inclusion bodies (HP:0100314)3.09520589
26Akinesia (HP:0002304)3.08021627
27Absent septum pellucidum (HP:0001331)3.07036064
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.02493250
29Abnormal eating behavior (HP:0100738)3.00686444
30Drooling (HP:0002307)2.98394998
31Excessive salivation (HP:0003781)2.98394998
32Retinal dysplasia (HP:0007973)2.97438252
33Congenital stationary night blindness (HP:0007642)2.94568313
34Supernumerary spleens (HP:0009799)2.90604898
35Absence seizures (HP:0002121)2.89503470
36Limb dystonia (HP:0002451)2.88215888
37Abnormality of the septum pellucidum (HP:0007375)2.84559810
38Chronic hepatic failure (HP:0100626)2.83760374
39Blue irides (HP:0000635)2.81473358
40Ankle clonus (HP:0011448)2.80172320
41Spastic gait (HP:0002064)2.78550583
42Dialeptic seizures (HP:0011146)2.68594097
43Febrile seizures (HP:0002373)2.68261884
44Colon cancer (HP:0003003)2.66230647
45Medial flaring of the eyebrow (HP:0010747)2.65442000
46Abnormality of the renal medulla (HP:0100957)2.61350833
47Insidious onset (HP:0003587)2.60041827
48Termporal pattern (HP:0011008)2.60041827
49Gait imbalance (HP:0002141)2.55919607
50Generalized tonic-clonic seizures (HP:0002069)2.55655127
51Abnormal biliary tract physiology (HP:0012439)2.54925008
52Bile duct proliferation (HP:0001408)2.54925008
53Attenuation of retinal blood vessels (HP:0007843)2.52989657
54Dysmetria (HP:0001310)2.52018860
55Hemiparesis (HP:0001269)2.50734339
56Absent speech (HP:0001344)2.50717243
57Type II lissencephaly (HP:0007260)2.50019477
58Urinary urgency (HP:0000012)2.48128321
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.44093217
60Hypoplasia of the brainstem (HP:0002365)2.44093217
61Sleep apnea (HP:0010535)2.42502333
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.40010704
63Partial agenesis of the corpus callosum (HP:0001338)2.37106705
64Abnormal hair whorl (HP:0010721)2.36471957
65Truncal ataxia (HP:0002078)2.36076621
66Urinary bladder sphincter dysfunction (HP:0002839)2.34920591
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.34218832
68Aplasia involving bones of the upper limbs (HP:0009823)2.33935373
69Aplasia of the phalanges of the hand (HP:0009802)2.33935373
70Aplasia involving bones of the extremities (HP:0009825)2.33935373
71Lissencephaly (HP:0001339)2.33662577
72Abnormality of binocular vision (HP:0011514)2.33353759
73Diplopia (HP:0000651)2.33353759
74Peripheral hypomyelination (HP:0007182)2.32302686
75Inability to walk (HP:0002540)2.30396772
76Pendular nystagmus (HP:0012043)2.29508410
77Esotropia (HP:0000565)2.29081699
78Narrow nasal bridge (HP:0000446)2.28434529
79Cystic liver disease (HP:0006706)2.28350139
80Stomach cancer (HP:0012126)2.27369737
81Gaze-evoked nystagmus (HP:0000640)2.26688457
82Myelomeningocele (HP:0002475)2.26268609
83Action tremor (HP:0002345)2.25898137
84Sensory axonal neuropathy (HP:0003390)2.23272424
85Papilledema (HP:0001085)2.23087759
86Anencephaly (HP:0002323)2.23009040
87Abnormality of the renal cortex (HP:0011035)2.22888074
88Dysdiadochokinesis (HP:0002075)2.21099319
89Parakeratosis (HP:0001036)2.19331947
90Megalencephaly (HP:0001355)2.19129199
91Amyotrophic lateral sclerosis (HP:0007354)2.18754455
92Progressive inability to walk (HP:0002505)2.18302709
93Abnormal ciliary motility (HP:0012262)2.17714979
94Failure to thrive in infancy (HP:0001531)2.16087275
95Protruding tongue (HP:0010808)2.15952298
96Congenital primary aphakia (HP:0007707)2.15795724
97Anteriorly placed anus (HP:0001545)2.14943919
98Impaired vibration sensation in the lower limbs (HP:0002166)2.14239370
99Sclerocornea (HP:0000647)2.12757890
100Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.12292325
101Patellar aplasia (HP:0006443)2.11382292
102Synostosis involving the elbow (HP:0003938)2.11016873
103Humeroradial synostosis (HP:0003041)2.11016873
104Abnormality of salivation (HP:0100755)2.10620223
105Poor eye contact (HP:0000817)2.09473351
106Split foot (HP:0001839)2.09106384
107Short tibia (HP:0005736)2.08301650
108Morphological abnormality of the pyramidal tract (HP:0002062)2.07922167
109Pheochromocytoma (HP:0002666)2.07561642
110Oligodactyly (hands) (HP:0001180)2.07535122
111Nephrogenic diabetes insipidus (HP:0009806)2.04130945
112Fetal akinesia sequence (HP:0001989)2.02559184
113Agitation (HP:0000713)2.01833495
114Abnormality of the labia minora (HP:0012880)2.01615988
115Amblyopia (HP:0000646)2.01596860
116Lower limb muscle weakness (HP:0007340)1.99998809
117Growth hormone deficiency (HP:0000824)1.99695611
118Epileptiform EEG discharges (HP:0011182)1.99033625
119Pachygyria (HP:0001302)1.98537211
120Alacrima (HP:0000522)1.98355986
121Specific learning disability (HP:0001328)1.97807167
122Postaxial hand polydactyly (HP:0001162)1.97069200
123Fair hair (HP:0002286)1.96827111
124Generalized myoclonic seizures (HP:0002123)1.95379899
125Aplasia/Hypoplasia of the patella (HP:0006498)1.95288217
126Intention tremor (HP:0002080)1.94633454
127Abnormal respiratory motile cilium morphology (HP:0005938)1.94324573
128Abnormal respiratory epithelium morphology (HP:0012253)1.94324573
129Preaxial hand polydactyly (HP:0001177)1.94264986
130Gastrointestinal atresia (HP:0002589)1.94207436
131EEG with generalized epileptiform discharges (HP:0011198)1.94078588
132Anxiety (HP:0000739)1.93452285
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.92932051
134Absent/shortened dynein arms (HP:0200106)1.92932051
135Scanning speech (HP:0002168)1.90611974
136Polydipsia (HP:0001959)1.89921608
137Abnormal drinking behavior (HP:0030082)1.89921608
138Facial hemangioma (HP:0000329)1.88896383
139Tubular atrophy (HP:0000092)1.88196562
140Postaxial foot polydactyly (HP:0001830)1.87947031
141Vaginal atresia (HP:0000148)1.87664403
142Abolished electroretinogram (ERG) (HP:0000550)1.87566974
143Depression (HP:0000716)1.87285199
144Intestinal atresia (HP:0011100)1.86980484
145Hypsarrhythmia (HP:0002521)1.86740680
146Bifid tongue (HP:0010297)1.86312762
147Torticollis (HP:0000473)1.85048484
148Renal cortical cysts (HP:0000803)1.84848689
149Genital tract atresia (HP:0001827)1.84337951
150Dandy-Walker malformation (HP:0001305)1.77190787
151Bony spicule pigmentary retinopathy (HP:0007737)1.75969868
152Decreased central vision (HP:0007663)1.75802658
153Narrow forehead (HP:0000341)1.75405105
154Chorioretinal atrophy (HP:0000533)1.74738671
155Methylmalonic acidemia (HP:0002912)1.73206542
156Anophthalmia (HP:0000528)1.72314283
157Rib fusion (HP:0000902)1.72159616
158Bilateral microphthalmos (HP:0007633)1.72076933
159Small hand (HP:0200055)1.70945213
160Occipital encephalocele (HP:0002085)1.68572519
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.65051624
162Hypothermia (HP:0002045)1.64552542
163Furrowed tongue (HP:0000221)1.64279149
164Congenital hepatic fibrosis (HP:0002612)1.61704480
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.60921953
166Hypoplasia of the fovea (HP:0007750)1.60921953
167Male pseudohermaphroditism (HP:0000037)1.60278732
168Neoplasm of the adrenal cortex (HP:0100641)1.57831176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.47136372
2CASK3.89162015
3TNIK2.97911587
4MAP4K22.96692588
5FRK2.93668649
6NTRK32.85458125
7MAP3K42.75198155
8NUAK12.72901523
9MAP2K72.64491970
10TLK12.64255556
11NTRK22.50451448
12ZAK2.48368014
13MAPK132.42340515
14MAP3K92.29303548
15EPHA42.21334939
16STK392.09346278
17MAP3K122.03703481
18PNCK1.98862424
19MINK11.96585426
20TRIM281.95239203
21OXSR11.92437808
22PRPF4B1.83817503
23PHKG21.78755546
24PHKG11.78755546
25MKNK21.74258973
26PINK11.68178030
27MAP2K41.58827338
28PAK61.58737056
29CDK191.56278127
30PKN11.56025432
31UHMK11.51377819
32DYRK21.45796334
33BCR1.42249689
34ACVR1B1.41681053
35PAK31.36861266
36GRK11.32273480
37CSNK1G21.31397612
38NTRK11.28915698
39TYRO31.25903145
40INSRR1.23560324
41MUSK1.22332789
42CDK51.21808034
43MAP2K61.17351310
44CDC71.15530777
45FGR1.14006020
46MKNK11.11074427
47FES1.10920623
48VRK11.09767809
49CSNK1G31.07779345
50PLK21.07334347
51KSR11.05641799
52CAMK2A0.99952035
53PLK30.99865829
54CSNK1A1L0.98402282
55TAOK30.97012852
56NEK60.94647739
57SIK20.94517343
58CAMK2B0.92677196
59VRK20.92453107
60FGFR20.91520604
61LATS20.90212417
62PRKCG0.87875633
63PRKCE0.84615027
64TTK0.84230058
65DAPK20.83488704
66GRK50.83197115
67TAOK20.83050267
68TGFBR10.82033982
69SRPK10.80235418
70GRK70.79847259
71CDK140.77655630
72CSNK1G10.77477815
73CAMK1G0.77254595
74WNK40.77242960
75MARK20.75898746
76CDK180.75017099
77DYRK1A0.73998099
78SGK2230.73582626
79SGK4940.73582626
80WNK30.72367359
81CDK150.72262035
82MAP3K50.71599301
83TAF10.69751660
84STK110.69678879
85ERBB30.68958354
86PLK10.67484576
87BMPR1B0.67138982
88TIE10.66411632
89PDGFRA0.66235694
90MAPK120.65931767
91IRAK20.65818550
92CDK11A0.65775336
93DYRK30.62856103
94LIMK10.61095635
95EIF2AK30.60303526
96PRKD30.59050685
97PRKCH0.58458695
98STK38L0.58268685
99PRKCI0.57895352
100BCKDK0.57150872
101ROCK20.57000356
102MAPK150.56489365
103MAP3K60.56283643
104KSR20.54926592
105FYN0.54644676
106BRSK20.52292918
107AKT30.51988395
108CAMK2D0.51444086
109SGK10.51394107
110PLK40.50733483
111TSSK60.50107702
112STK160.49637285
113ATR0.49416802
114PDGFRB0.49333064
115DDR20.48814769
116ATM0.48422681
117PRKCZ0.48382069
118NLK0.48266807
119BUB10.47570984
120ERBB40.47262713
121NME10.46942634
122WNK10.43393246
123MAP3K20.42210780
124PRKG10.41957256
125STK30.41747948
126ADRBK10.41043657
127CSNK1D0.40613467
128CHEK20.40455004
129ADRBK20.40401578
130CAMKK10.40319097
131MAPKAPK50.39396919
132EPHB20.38319003
133CSNK1E0.38296280
134CAMKK20.38252091
135CAMK2G0.37935265
136PIK3CA0.37634348
137LATS10.37407649
138CAMK10.37219593
139RPS6KA30.36602234
140EPHB10.36331670
141RIPK40.35975894
142PRKACA0.35886258
143AURKA0.35869523
144CSNK1A10.35594909
145MAPK100.35204854
146ICK0.34491085

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11200313
2GABAergic synapse_Homo sapiens_hsa047272.81832185
3Basal transcription factors_Homo sapiens_hsa030222.69391711
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68020821
5Synaptic vesicle cycle_Homo sapiens_hsa047212.59944284
6Glutamatergic synapse_Homo sapiens_hsa047242.53692943
7Morphine addiction_Homo sapiens_hsa050322.45539304
8Circadian entrainment_Homo sapiens_hsa047132.25472918
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10540283
10Axon guidance_Homo sapiens_hsa043602.07489647
11Serotonergic synapse_Homo sapiens_hsa047262.02595684
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01438417
13Homologous recombination_Homo sapiens_hsa034401.95711697
14Amphetamine addiction_Homo sapiens_hsa050311.95662365
15Dopaminergic synapse_Homo sapiens_hsa047281.94773178
16Olfactory transduction_Homo sapiens_hsa047401.92392784
17Long-term potentiation_Homo sapiens_hsa047201.87293956
18Fanconi anemia pathway_Homo sapiens_hsa034601.87281578
19RNA degradation_Homo sapiens_hsa030181.87102224
20Cocaine addiction_Homo sapiens_hsa050301.82840166
21Long-term depression_Homo sapiens_hsa047301.81304555
22Selenocompound metabolism_Homo sapiens_hsa004501.77675367
23RNA polymerase_Homo sapiens_hsa030201.77223692
24Oxidative phosphorylation_Homo sapiens_hsa001901.65114405
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64745911
26Salivary secretion_Homo sapiens_hsa049701.63126860
27Collecting duct acid secretion_Homo sapiens_hsa049661.61748694
28Steroid biosynthesis_Homo sapiens_hsa001001.61730502
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60095520
30Cholinergic synapse_Homo sapiens_hsa047251.59657831
31Renin secretion_Homo sapiens_hsa049241.57888541
32Linoleic acid metabolism_Homo sapiens_hsa005911.56115458
33Caffeine metabolism_Homo sapiens_hsa002321.55714205
34Taste transduction_Homo sapiens_hsa047421.51537161
35Insulin secretion_Homo sapiens_hsa049111.51029776
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49976396
37Non-homologous end-joining_Homo sapiens_hsa034501.49972518
38Gap junction_Homo sapiens_hsa045401.48980804
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45562047
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41096210
41Gastric acid secretion_Homo sapiens_hsa049711.40869717
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38763023
43Cardiac muscle contraction_Homo sapiens_hsa042601.36704392
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36632471
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32212275
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32167818
47Oxytocin signaling pathway_Homo sapiens_hsa049211.31480482
48Mismatch repair_Homo sapiens_hsa034301.31169263
49Propanoate metabolism_Homo sapiens_hsa006401.29933442
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27811329
51Nitrogen metabolism_Homo sapiens_hsa009101.27348873
52Alzheimers disease_Homo sapiens_hsa050101.26596428
53Calcium signaling pathway_Homo sapiens_hsa040201.25331987
54ErbB signaling pathway_Homo sapiens_hsa040121.23600405
55Protein export_Homo sapiens_hsa030601.21911484
56Parkinsons disease_Homo sapiens_hsa050121.19567286
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19549353
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19489076
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15907669
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.15461513
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14855001
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13947111
63RNA transport_Homo sapiens_hsa030131.13934549
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13023571
65Circadian rhythm_Homo sapiens_hsa047101.10314775
66Phototransduction_Homo sapiens_hsa047441.09104617
67Ether lipid metabolism_Homo sapiens_hsa005651.07198225
68GnRH signaling pathway_Homo sapiens_hsa049121.06789343
69Vibrio cholerae infection_Homo sapiens_hsa051101.04187473
70Estrogen signaling pathway_Homo sapiens_hsa049151.02619590
71Maturity onset diabetes of the young_Homo sapiens_hsa049501.00987918
72Tryptophan metabolism_Homo sapiens_hsa003800.99642164
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96037834
74Renal cell carcinoma_Homo sapiens_hsa052110.94941694
75cAMP signaling pathway_Homo sapiens_hsa040240.94626823
76Melanogenesis_Homo sapiens_hsa049160.93996976
77Glioma_Homo sapiens_hsa052140.93478177
78Regulation of autophagy_Homo sapiens_hsa041400.92845671
79Butanoate metabolism_Homo sapiens_hsa006500.90208796
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89682716
81Fatty acid elongation_Homo sapiens_hsa000620.83703501
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82951665
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.82560617
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82416857
85Purine metabolism_Homo sapiens_hsa002300.82209091
86Huntingtons disease_Homo sapiens_hsa050160.78825385
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78266698
88Base excision repair_Homo sapiens_hsa034100.77724800
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77261744
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.75766759
91Nucleotide excision repair_Homo sapiens_hsa034200.75483109
92Dorso-ventral axis formation_Homo sapiens_hsa043200.74903518
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.73538654
94Ras signaling pathway_Homo sapiens_hsa040140.73353712
95Sphingolipid metabolism_Homo sapiens_hsa006000.71510205
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71282076
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70941953
98Choline metabolism in cancer_Homo sapiens_hsa052310.70382225
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69544166
100MAPK signaling pathway_Homo sapiens_hsa040100.69164049
101Type II diabetes mellitus_Homo sapiens_hsa049300.69118661
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.68431800
103Peroxisome_Homo sapiens_hsa041460.67485639
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66991828
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.66400733
106Wnt signaling pathway_Homo sapiens_hsa043100.65929212
107Retinol metabolism_Homo sapiens_hsa008300.65686493
108One carbon pool by folate_Homo sapiens_hsa006700.64298026
109Cell cycle_Homo sapiens_hsa041100.64229844
110Alcoholism_Homo sapiens_hsa050340.62886846
111Dilated cardiomyopathy_Homo sapiens_hsa054140.62598871
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60937693
113ABC transporters_Homo sapiens_hsa020100.60678082
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57758348
115Prion diseases_Homo sapiens_hsa050200.57348457
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56477512
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56118714
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55189171
119Proteasome_Homo sapiens_hsa030500.53656930
120Chemical carcinogenesis_Homo sapiens_hsa052040.53350512
121mRNA surveillance pathway_Homo sapiens_hsa030150.53118616
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52832314
123Hippo signaling pathway_Homo sapiens_hsa043900.52814827
124Metabolic pathways_Homo sapiens_hsa011000.51455721
125Pancreatic secretion_Homo sapiens_hsa049720.50513562
126Ovarian steroidogenesis_Homo sapiens_hsa049130.49733074
127Pyrimidine metabolism_Homo sapiens_hsa002400.49586924
128Vitamin digestion and absorption_Homo sapiens_hsa049770.48949175
129Thyroid hormone synthesis_Homo sapiens_hsa049180.48605164
130Basal cell carcinoma_Homo sapiens_hsa052170.46176492
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45085455
132Hedgehog signaling pathway_Homo sapiens_hsa043400.44208820
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44120882
134Rap1 signaling pathway_Homo sapiens_hsa040150.42450769
135Tight junction_Homo sapiens_hsa045300.42412916
136Rheumatoid arthritis_Homo sapiens_hsa053230.41254690
137Fatty acid biosynthesis_Homo sapiens_hsa000610.41123734
138Sulfur metabolism_Homo sapiens_hsa009200.40102970
139p53 signaling pathway_Homo sapiens_hsa041150.39222855
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38563725
141DNA replication_Homo sapiens_hsa030300.38441363
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37850713
143Melanoma_Homo sapiens_hsa052180.36315050
144TGF-beta signaling pathway_Homo sapiens_hsa043500.35189707
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34834720
146beta-Alanine metabolism_Homo sapiens_hsa004100.34668714
147Oocyte meiosis_Homo sapiens_hsa041140.34359391
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33946455
149Phagosome_Homo sapiens_hsa041450.33292463
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32295368
151African trypanosomiasis_Homo sapiens_hsa051430.30626281
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30478649
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29955768
154Type I diabetes mellitus_Homo sapiens_hsa049400.29395754
155Sulfur relay system_Homo sapiens_hsa041220.27615955
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25667112

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