PCDH11Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.13441847
2gamma-aminobutyric acid transport (GO:0015812)4.25227666
3pyrimidine nucleobase catabolic process (GO:0006208)4.12827421
4fucose catabolic process (GO:0019317)3.76340910
5L-fucose metabolic process (GO:0042354)3.76340910
6L-fucose catabolic process (GO:0042355)3.76340910
7response to pheromone (GO:0019236)3.69262887
8nucleobase catabolic process (GO:0046113)3.59568132
9protein localization to cilium (GO:0061512)3.45464707
10water-soluble vitamin biosynthetic process (GO:0042364)3.44925390
11behavioral response to ethanol (GO:0048149)3.28666366
12postsynaptic membrane organization (GO:0001941)3.26406532
13neuron cell-cell adhesion (GO:0007158)3.22456684
14protein polyglutamylation (GO:0018095)3.20703633
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19967320
16presynaptic membrane assembly (GO:0097105)3.19885847
17primary amino compound metabolic process (GO:1901160)3.17788517
18intraciliary transport (GO:0042073)3.16557705
19piRNA metabolic process (GO:0034587)3.15212909
20serotonin metabolic process (GO:0042428)3.06330916
21neuronal action potential (GO:0019228)3.03664861
22protein localization to synapse (GO:0035418)3.03153867
23epithelial cilium movement (GO:0003351)3.02747482
24C4-dicarboxylate transport (GO:0015740)2.99510520
25presynaptic membrane organization (GO:0097090)2.94888880
26transmission of nerve impulse (GO:0019226)2.92846983
27vocalization behavior (GO:0071625)2.92699768
28negative regulation of telomere maintenance (GO:0032205)2.92123653
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88666402
30negative regulation of translation, ncRNA-mediated (GO:0040033)2.85924103
31regulation of translation, ncRNA-mediated (GO:0045974)2.85924103
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85924103
33negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84572503
34cornea development in camera-type eye (GO:0061303)2.84372221
35protein complex biogenesis (GO:0070271)2.81408267
36negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80150302
37indolalkylamine metabolic process (GO:0006586)2.80109085
38regulation of nuclear cell cycle DNA replication (GO:0033262)2.79349147
39proline transport (GO:0015824)2.77032511
40respiratory chain complex IV assembly (GO:0008535)2.76931167
41platelet dense granule organization (GO:0060155)2.76495873
42cilium organization (GO:0044782)2.76208406
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75301176
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.75301176
45NADH dehydrogenase complex assembly (GO:0010257)2.75301176
46neural tube formation (GO:0001841)2.74257007
47startle response (GO:0001964)2.73637793
48DNA methylation involved in gamete generation (GO:0043046)2.73125110
49retinal cone cell development (GO:0046549)2.72601466
50mechanosensory behavior (GO:0007638)2.72192287
51detection of light stimulus involved in sensory perception (GO:0050962)2.71890511
52detection of light stimulus involved in visual perception (GO:0050908)2.71890511
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71762211
54cilium assembly (GO:0042384)2.71456495
55negative regulation of mast cell activation (GO:0033004)2.70968791
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70589215
57mitochondrial respiratory chain complex assembly (GO:0033108)2.70483024
58DNA double-strand break processing (GO:0000729)2.70109138
59axoneme assembly (GO:0035082)2.68559041
60positive regulation of oligodendrocyte differentiation (GO:0048714)2.68537623
61neuronal action potential propagation (GO:0019227)2.66904331
62kynurenine metabolic process (GO:0070189)2.66562033
63regulation of mitotic spindle checkpoint (GO:1903504)2.65959369
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65959369
65nonmotile primary cilium assembly (GO:0035058)2.64023999
66indole-containing compound metabolic process (GO:0042430)2.63671000
67auditory behavior (GO:0031223)2.61902765
68synaptic transmission, glutamatergic (GO:0035249)2.61738712
69regulation of telomere maintenance (GO:0032204)2.59363184
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59093046
71kidney morphogenesis (GO:0060993)2.59056187
72protein-cofactor linkage (GO:0018065)2.59047474
73protein neddylation (GO:0045116)2.59002371
74calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58538568
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58273673
76cilium morphogenesis (GO:0060271)2.57986751
77indole-containing compound catabolic process (GO:0042436)2.56921643
78indolalkylamine catabolic process (GO:0046218)2.56921643
79tryptophan catabolic process (GO:0006569)2.56921643
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56636380
81regulation of action potential (GO:0098900)2.56433598
82cilium movement (GO:0003341)2.56116624
83regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51623947
84retinal ganglion cell axon guidance (GO:0031290)2.51249919
85cilium or flagellum-dependent cell motility (GO:0001539)2.51145105
86membrane depolarization during action potential (GO:0086010)2.49350415
87ubiquinone metabolic process (GO:0006743)2.47929743
88photoreceptor cell development (GO:0042461)2.47656233
89regulation of cilium movement (GO:0003352)2.47052183
90rhodopsin mediated signaling pathway (GO:0016056)2.42565819
91negative regulation of axon guidance (GO:1902668)2.41872525
92synaptic transmission, cholinergic (GO:0007271)2.41359883
93ubiquinone biosynthetic process (GO:0006744)2.41204013
94glycosphingolipid biosynthetic process (GO:0006688)2.40229729
95protein K11-linked deubiquitination (GO:0035871)2.40202656
96reflex (GO:0060004)2.39956903
97somite development (GO:0061053)2.39125468
98synapse assembly (GO:0007416)2.38422652
99cytochrome complex assembly (GO:0017004)2.38222956
100replication fork processing (GO:0031297)2.38194949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.72531746
2EZH2_22144423_ChIP-Seq_EOC_Human3.20930760
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05919142
4GBX2_23144817_ChIP-Seq_PC3_Human3.04967150
5VDR_22108803_ChIP-Seq_LS180_Human2.93193051
6* IGF1R_20145208_ChIP-Seq_DFB_Human2.82833380
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82044252
8TAF15_26573619_Chip-Seq_HEK293_Human2.70047915
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51721162
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36404730
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35515585
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24703919
13FUS_26573619_Chip-Seq_HEK293_Human2.18637531
14EWS_26573619_Chip-Seq_HEK293_Human2.17838105
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16181134
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16044007
17P300_19829295_ChIP-Seq_ESCs_Human2.14673158
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.11732474
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.03347674
20IRF1_19129219_ChIP-ChIP_H3396_Human1.93340147
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88164180
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84377935
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76222123
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72156813
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69288940
26REST_21632747_ChIP-Seq_MESCs_Mouse1.69176251
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63429447
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61758355
29ER_23166858_ChIP-Seq_MCF-7_Human1.61200124
30RNF2_27304074_Chip-Seq_NSC_Mouse1.59929259
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59752080
32SMAD4_21799915_ChIP-Seq_A2780_Human1.59488142
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.58341727
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.55911804
35BCAT_22108803_ChIP-Seq_LS180_Human1.54215227
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53033717
37STAT3_23295773_ChIP-Seq_U87_Human1.50217156
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49106993
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45606204
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45020043
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44513638
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44513638
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44501883
44AR_25329375_ChIP-Seq_VCAP_Human1.43977937
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43316275
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42470102
47TCF4_23295773_ChIP-Seq_U87_Human1.42259037
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41449147
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40932857
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.39181541
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39037035
52CBP_20019798_ChIP-Seq_JUKART_Human1.39037035
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38772429
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38638670
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38633722
56TP53_22573176_ChIP-Seq_HFKS_Human1.38313211
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36531927
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36068886
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31940158
60RUNX2_22187159_ChIP-Seq_PCA_Human1.28539209
61AR_21572438_ChIP-Seq_LNCaP_Human1.28134955
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.27964319
63TCF4_22108803_ChIP-Seq_LS180_Human1.25853344
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25807670
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25560993
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.23782573
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23158251
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21974003
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.21934866
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21550019
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21000969
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20541912
73SOX2_19829295_ChIP-Seq_ESCs_Human1.20400377
74NANOG_19829295_ChIP-Seq_ESCs_Human1.20400377
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19773263
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.19642034
77MYC_18940864_ChIP-ChIP_HL60_Human1.18420222
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.13279531
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.12693897
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.12325702
81GABP_17652178_ChIP-ChIP_JURKAT_Human1.11360850
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.09663143
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09157804
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07602559
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.07602559
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.06151662
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05813618
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05507493
89JUN_21703547_ChIP-Seq_K562_Human1.05319031
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.05110322
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.02747186
92NCOR_22424771_ChIP-Seq_293T_Human1.02614181
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.02179780
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01764116
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00557347
96P53_22387025_ChIP-Seq_ESCs_Mouse1.00313931
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99083631
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98588600
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98377527
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98070320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.07281450
2MP0003880_abnormal_central_pattern2.79839685
3MP0002102_abnormal_ear_morphology2.76793520
4MP0003787_abnormal_imprinting2.72839498
5MP0001968_abnormal_touch/_nociception2.70238477
6MP0006292_abnormal_olfactory_placode2.67715516
7MP0002736_abnormal_nociception_after2.58029699
8MP0005551_abnormal_eye_electrophysiolog2.25478981
9MP0009745_abnormal_behavioral_response2.21914313
10MP0009046_muscle_twitch2.06942561
11MP0006276_abnormal_autonomic_nervous2.06013501
12MP0002272_abnormal_nervous_system2.03908108
13MP0002735_abnormal_chemical_nociception1.96267964
14MP0004133_heterotaxia1.93101215
15MP0001486_abnormal_startle_reflex1.90667354
16MP0006072_abnormal_retinal_apoptosis1.87910018
17MP0003635_abnormal_synaptic_transmissio1.86861690
18MP0002653_abnormal_ependyma_morphology1.82803921
19MP0000569_abnormal_digit_pigmentation1.82027825
20MP0003121_genomic_imprinting1.81403884
21MP0003122_maternal_imprinting1.80997576
22MP0002572_abnormal_emotion/affect_behav1.74106259
23MP0001529_abnormal_vocalization1.73934553
24MP0000778_abnormal_nervous_system1.71029979
25MP0002063_abnormal_learning/memory/cond1.68467817
26MP0002064_seizures1.67483178
27MP0004147_increased_porphyrin_level1.65089170
28MP0004859_abnormal_synaptic_plasticity1.64428367
29MP0003195_calcinosis1.58412963
30MP0004142_abnormal_muscle_tone1.56996150
31MP0001485_abnormal_pinna_reflex1.56969147
32MP0002733_abnormal_thermal_nociception1.55045294
33MP0005253_abnormal_eye_physiology1.53995056
34MP0005646_abnormal_pituitary_gland1.53969169
35MP0003890_abnormal_embryonic-extraembry1.53089251
36MP0002734_abnormal_mechanical_nocicepti1.52121231
37MP0000427_abnormal_hair_cycle1.51841403
38MP0001501_abnormal_sleep_pattern1.51628636
39MP0003136_yellow_coat_color1.50256931
40MP0002638_abnormal_pupillary_reflex1.48858976
41MP0004043_abnormal_pH_regulation1.48643491
42MP0000631_abnormal_neuroendocrine_gland1.46700497
43MP0002557_abnormal_social/conspecific_i1.46400876
44MP0001970_abnormal_pain_threshold1.44633051
45MP0008872_abnormal_physiological_respon1.43590415
46MP0002837_dystrophic_cardiac_calcinosis1.42988226
47MP0004885_abnormal_endolymph1.42794029
48MP0002067_abnormal_sensory_capabilities1.41503268
49MP0005645_abnormal_hypothalamus_physiol1.41472596
50MP0004270_analgesia1.39897717
51MP0002938_white_spotting1.39093043
52MP0002184_abnormal_innervation1.38813768
53MP0004742_abnormal_vestibular_system1.38158285
54MP0001986_abnormal_taste_sensitivity1.32979238
55MP0002234_abnormal_pharynx_morphology1.32023175
56MP0001984_abnormal_olfaction1.31412960
57MP0002751_abnormal_autonomic_nervous1.23842964
58MP0008875_abnormal_xenobiotic_pharmacok1.17566308
59MP0003646_muscle_fatigue1.16854797
60MP0003011_delayed_dark_adaptation1.16519217
61MP0002752_abnormal_somatic_nervous1.16381537
62MP0004145_abnormal_muscle_electrophysio1.16368309
63MP0010386_abnormal_urinary_bladder1.15841444
64MP0004924_abnormal_behavior1.13382543
65MP0005386_behavior/neurological_phenoty1.13382543
66MP0001293_anophthalmia1.11393965
67MP0001188_hyperpigmentation1.09785179
68MP0005423_abnormal_somatic_nervous1.07548540
69MP0002822_catalepsy1.04612315
70MP0003567_abnormal_fetal_cardiomyocyte1.04098004
71MP0005084_abnormal_gallbladder_morpholo1.03832403
72MP0005195_abnormal_posterior_eye1.03603223
73MP0002876_abnormal_thyroid_physiology1.03443745
74MP0002882_abnormal_neuron_morphology1.03303458
75MP0000647_abnormal_sebaceous_gland1.01589364
76MP0001440_abnormal_grooming_behavior1.01016171
77MP0000955_abnormal_spinal_cord1.00989820
78MP0008789_abnormal_olfactory_epithelium1.00543656
79MP0001963_abnormal_hearing_physiology0.97434634
80MP0000372_irregular_coat_pigmentation0.97326584
81MP0004215_abnormal_myocardial_fiber0.97279456
82MP0002160_abnormal_reproductive_system0.97137413
83MP0002229_neurodegeneration0.96848449
84MP0003123_paternal_imprinting0.95542610
85MP0001905_abnormal_dopamine_level0.94924389
86MP0003718_maternal_effect0.93150407
87MP0008058_abnormal_DNA_repair0.92629584
88MP0003937_abnormal_limbs/digits/tail_de0.88936839
89MP0001324_abnormal_eye_pigmentation0.88658766
90MP0000026_abnormal_inner_ear0.87453488
91MP0003119_abnormal_digestive_system0.86070320
92MP0001502_abnormal_circadian_rhythm0.85970621
93MP0005499_abnormal_olfactory_system0.85803493
94MP0005394_taste/olfaction_phenotype0.85803493
95MP0005389_reproductive_system_phenotype0.83335823
96MP0005379_endocrine/exocrine_gland_phen0.82420617
97MP0002909_abnormal_adrenal_gland0.81417708
98MP0000383_abnormal_hair_follicle0.80657403
99MP0002152_abnormal_brain_morphology0.80582585
100MP0003698_abnormal_male_reproductive0.80057966

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.09459199
2Pancreatic cysts (HP:0001737)3.97369531
3Molar tooth sign on MRI (HP:0002419)3.86602094
4Abnormality of midbrain morphology (HP:0002418)3.86602094
5Nephronophthisis (HP:0000090)3.71421580
6True hermaphroditism (HP:0010459)3.69177927
7Congenital stationary night blindness (HP:0007642)3.50864435
8Medial flaring of the eyebrow (HP:0010747)3.39220124
9Hyperventilation (HP:0002883)3.30986415
10Abnormality of the renal medulla (HP:0100957)3.08424960
11Gait imbalance (HP:0002141)3.07805696
12Congenital primary aphakia (HP:0007707)2.83448522
13Focal motor seizures (HP:0011153)2.81275652
14Nephrogenic diabetes insipidus (HP:0009806)2.80405905
15Lissencephaly (HP:0001339)2.80077580
16Abnormality of the renal cortex (HP:0011035)2.75523834
17Type II lissencephaly (HP:0007260)2.68540493
18Abnormality of the labia minora (HP:0012880)2.66121153
19Genital tract atresia (HP:0001827)2.64595640
20Inability to walk (HP:0002540)2.64234149
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.63122973
22Cystic liver disease (HP:0006706)2.49806218
23Colon cancer (HP:0003003)2.47869885
24Progressive inability to walk (HP:0002505)2.45443747
25Vaginal atresia (HP:0000148)2.43842734
26Chronic hepatic failure (HP:0100626)2.41670756
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.41508229
28Progressive cerebellar ataxia (HP:0002073)2.36015105
29Hypothermia (HP:0002045)2.34262276
30Drooling (HP:0002307)2.33800135
31Sclerocornea (HP:0000647)2.33749655
32Febrile seizures (HP:0002373)2.32712102
33Methylmalonic acidemia (HP:0002912)2.31904229
34Focal seizures (HP:0007359)2.29877289
35Pachygyria (HP:0001302)2.29392088
36Tubular atrophy (HP:0000092)2.28884192
37Broad-based gait (HP:0002136)2.28238259
38Anencephaly (HP:0002323)2.27971181
39Postaxial foot polydactyly (HP:0001830)2.27730886
40Limb dystonia (HP:0002451)2.24911085
41Acute necrotizing encephalopathy (HP:0006965)2.22412249
42Renal cortical cysts (HP:0000803)2.22304043
43Genetic anticipation (HP:0003743)2.17422039
44Short tibia (HP:0005736)2.16942606
45Abnormal drinking behavior (HP:0030082)2.16708272
46Polydipsia (HP:0001959)2.16708272
47Attenuation of retinal blood vessels (HP:0007843)2.10089183
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09457312
49Progressive macrocephaly (HP:0004481)2.09131841
50Excessive salivation (HP:0003781)2.08295129
51Pendular nystagmus (HP:0012043)2.07531475
52Abnormal biliary tract physiology (HP:0012439)2.04842519
53Bile duct proliferation (HP:0001408)2.04842519
54Acute encephalopathy (HP:0006846)2.04767494
55Abolished electroretinogram (ERG) (HP:0000550)2.04576514
56Postaxial hand polydactyly (HP:0001162)2.04386996
57Supernumerary spleens (HP:0009799)2.03488794
58Protruding tongue (HP:0010808)2.03436660
59Poor coordination (HP:0002370)2.02537175
60Congenital hepatic fibrosis (HP:0002612)2.02419152
61Methylmalonic aciduria (HP:0012120)2.01520584
62Polyphagia (HP:0002591)2.01014673
63Optic nerve hypoplasia (HP:0000609)1.99786076
64Hyperglycinemia (HP:0002154)1.98791021
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98574695
66Abnormality of alanine metabolism (HP:0010916)1.98574695
67Hyperalaninemia (HP:0003348)1.98574695
68Dialeptic seizures (HP:0011146)1.98166713
69Increased CSF lactate (HP:0002490)1.97312079
70Gaze-evoked nystagmus (HP:0000640)1.96672619
71Hyperglycinuria (HP:0003108)1.92073617
72Mitochondrial inheritance (HP:0001427)1.88818108
73Absent speech (HP:0001344)1.87791438
74Amyotrophic lateral sclerosis (HP:0007354)1.87746752
75Dandy-Walker malformation (HP:0001305)1.86489470
76Male pseudohermaphroditism (HP:0000037)1.85927235
77Epileptic encephalopathy (HP:0200134)1.85650771
78Abnormal rod and cone electroretinograms (HP:0008323)1.85035520
79Intestinal atresia (HP:0011100)1.83805442
80Patellar aplasia (HP:0006443)1.82550961
81Abnormal mitochondria in muscle tissue (HP:0008316)1.81634216
82Polyuria (HP:0000103)1.79469100
83Abnormality of glycine metabolism (HP:0010895)1.78310461
84Abnormality of serine family amino acid metabolism (HP:0010894)1.78310461
85Dyskinesia (HP:0100660)1.77176676
86Specific learning disability (HP:0001328)1.77141966
87Narrow forehead (HP:0000341)1.76651858
88Aplasia/Hypoplasia of the patella (HP:0006498)1.75826171
89Preaxial hand polydactyly (HP:0001177)1.75526942
90Tachypnea (HP:0002789)1.75519902
91Retinal dysplasia (HP:0007973)1.73791695
92Large for gestational age (HP:0001520)1.73722499
93Furrowed tongue (HP:0000221)1.72964227
94Dynein arm defect of respiratory motile cilia (HP:0012255)1.72588408
95Absent/shortened dynein arms (HP:0200106)1.72588408
96Stomach cancer (HP:0012126)1.72021260
97Oligodactyly (hands) (HP:0001180)1.70524814
98Increased corneal curvature (HP:0100692)1.70283238
99Keratoconus (HP:0000563)1.70283238
100Decreased central vision (HP:0007663)1.69813146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.77185950
2CASK3.30057846
3WNK32.90296890
4MAPK132.69248508
5MAP4K22.58065866
6MARK12.50700431
7ADRBK22.42404469
8PINK12.40475875
9TRIM282.32636752
10TNIK2.22484525
11GRK12.20952484
12ZAK2.16706956
13ACVR1B2.13907494
14NUAK12.10496747
15BMPR1B1.93359807
16BCR1.91759051
17MAP3K41.87129840
18MKNK21.77405611
19INSRR1.72107907
20DYRK21.63510027
21EPHA41.54829546
22TLK11.54546118
23PAK31.52446148
24CSNK1G21.51366248
25WNK41.50152795
26STK38L1.44573064
27MAP2K71.41567576
28NTRK31.40102104
29DAPK21.39334278
30CAMKK21.34299694
31OXSR11.33896731
32MKNK11.26930650
33TAOK31.23303441
34PRKCG1.17178643
35CSNK1G11.13860892
36CSNK1G31.09136703
37PLK21.03863183
38AKT31.03296192
39PHKG11.01138179
40PHKG21.01138179
41TIE10.99320885
42CSNK1A1L0.94243453
43PRKCE0.91473240
44STK390.90655764
45PLK30.89604669
46MINK10.88579292
47NTRK20.86933751
48ADRBK10.83220637
49CAMK2A0.80349015
50VRK10.78795747
51PRKD30.78201140
52PLK40.78146691
53PIK3CA0.76040290
54TAF10.75256172
55BRSK20.73437130
56NEK10.73335475
57PNCK0.72500716
58DYRK1A0.72053804
59FER0.71594147
60DYRK30.70164570
61UHMK10.68038573
62VRK20.67412368
63ERBB30.66077554
64BCKDK0.63461785
65TSSK60.59418974
66TXK0.58885238
67CAMK10.58608937
68MUSK0.56847015
69STK160.54784059
70CSNK1A10.54655140
71PTK2B0.54227531
72MAPKAPK50.53830024
73NEK20.52239905
74TGFBR10.50694013
75NME10.49879500
76STK110.49644188
77SGK4940.49131227
78SGK2230.49131227
79CDK50.48995303
80CAMK40.47882683
81PRKACA0.46716764
82SGK20.44331987
83PKN10.44260724
84RPS6KA50.43237981
85FGFR20.43042819
86CAMK2B0.42503869
87PLK10.41877207
88CSNK1D0.41024018
89GRK70.40923310
90PRKCI0.40088300
91GRK50.39810900
92MAP2K40.38974394
93PRKAA10.38627875
94PRKCZ0.36300056
95TEC0.35714542
96EPHA30.34950162
97CSNK1E0.33681871
98ERBB20.32577101
99PRKCA0.32243495
100CDK190.31023282

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38678478
2Phototransduction_Homo sapiens_hsa047443.01562898
3Oxidative phosphorylation_Homo sapiens_hsa001902.16389349
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11557055
5Linoleic acid metabolism_Homo sapiens_hsa005912.10950844
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06744945
7Protein export_Homo sapiens_hsa030602.02330879
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98255861
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94005269
10GABAergic synapse_Homo sapiens_hsa047271.92140355
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89065659
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86889364
13Basal transcription factors_Homo sapiens_hsa030221.84595737
14Morphine addiction_Homo sapiens_hsa050321.83606879
15Propanoate metabolism_Homo sapiens_hsa006401.81064627
16Parkinsons disease_Homo sapiens_hsa050121.76714871
17Butanoate metabolism_Homo sapiens_hsa006501.75488200
18Fanconi anemia pathway_Homo sapiens_hsa034601.73446519
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71558161
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68403540
21Nitrogen metabolism_Homo sapiens_hsa009101.67813153
22Taste transduction_Homo sapiens_hsa047421.67189032
23Ether lipid metabolism_Homo sapiens_hsa005651.67119469
24Circadian entrainment_Homo sapiens_hsa047131.62667984
25RNA polymerase_Homo sapiens_hsa030201.61629805
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58210679
27Glutamatergic synapse_Homo sapiens_hsa047241.56875563
28Selenocompound metabolism_Homo sapiens_hsa004501.50720840
29Tryptophan metabolism_Homo sapiens_hsa003801.50202131
30Homologous recombination_Homo sapiens_hsa034401.45689988
31Olfactory transduction_Homo sapiens_hsa047401.45274276
32Serotonergic synapse_Homo sapiens_hsa047261.42115871
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38647524
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38003803
35Non-homologous end-joining_Homo sapiens_hsa034501.32324417
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.31569284
37Insulin secretion_Homo sapiens_hsa049111.27240254
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26208092
39Dopaminergic synapse_Homo sapiens_hsa047281.25102482
40Cardiac muscle contraction_Homo sapiens_hsa042601.22542165
41Huntingtons disease_Homo sapiens_hsa050161.20086207
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17450092
43RNA degradation_Homo sapiens_hsa030181.16111927
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14777434
45Alzheimers disease_Homo sapiens_hsa050101.10787185
46Caffeine metabolism_Homo sapiens_hsa002321.10711451
47Amphetamine addiction_Homo sapiens_hsa050311.09503960
48Cocaine addiction_Homo sapiens_hsa050301.06398702
49Steroid biosynthesis_Homo sapiens_hsa001001.01021037
50Synaptic vesicle cycle_Homo sapiens_hsa047210.97723494
51Peroxisome_Homo sapiens_hsa041460.96767255
52beta-Alanine metabolism_Homo sapiens_hsa004100.90940907
53Regulation of autophagy_Homo sapiens_hsa041400.88277685
54Collecting duct acid secretion_Homo sapiens_hsa049660.87161657
55Salivary secretion_Homo sapiens_hsa049700.86690891
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.85593901
57Histidine metabolism_Homo sapiens_hsa003400.85110957
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84834156
59Long-term depression_Homo sapiens_hsa047300.82531697
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.80094056
61Fatty acid elongation_Homo sapiens_hsa000620.79257845
62One carbon pool by folate_Homo sapiens_hsa006700.78031069
63Arachidonic acid metabolism_Homo sapiens_hsa005900.76272191
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74610317
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74353361
66Chemical carcinogenesis_Homo sapiens_hsa052040.72794610
67Retinol metabolism_Homo sapiens_hsa008300.72446408
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70832247
69Cholinergic synapse_Homo sapiens_hsa047250.69108454
70Calcium signaling pathway_Homo sapiens_hsa040200.68786573
71Purine metabolism_Homo sapiens_hsa002300.68465166
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.67775639
73Vitamin B6 metabolism_Homo sapiens_hsa007500.67508888
74Axon guidance_Homo sapiens_hsa043600.66715496
75Ovarian steroidogenesis_Homo sapiens_hsa049130.64731548
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64294372
77Circadian rhythm_Homo sapiens_hsa047100.59267145
78Fat digestion and absorption_Homo sapiens_hsa049750.58171848
79Metabolic pathways_Homo sapiens_hsa011000.57877349
80Hedgehog signaling pathway_Homo sapiens_hsa043400.57381188
81Arginine and proline metabolism_Homo sapiens_hsa003300.56023932
82Glycerolipid metabolism_Homo sapiens_hsa005610.52717052
83ABC transporters_Homo sapiens_hsa020100.51275508
84Fatty acid degradation_Homo sapiens_hsa000710.50367384
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49258809
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48844393
87Gastric acid secretion_Homo sapiens_hsa049710.48805386
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48707150
89Proteasome_Homo sapiens_hsa030500.48474653
90Sulfur metabolism_Homo sapiens_hsa009200.47088453
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46674053
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46491839
93cAMP signaling pathway_Homo sapiens_hsa040240.44901839
94Oxytocin signaling pathway_Homo sapiens_hsa049210.44702956
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43805979
96RNA transport_Homo sapiens_hsa030130.43757126
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42036493
98Fatty acid metabolism_Homo sapiens_hsa012120.41104028
99Mineral absorption_Homo sapiens_hsa049780.40298020
100Vitamin digestion and absorption_Homo sapiens_hsa049770.39156000

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