ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	vascular endothelial growth factor signaling pathway (GO:0038084)	6.44244697
2	lymph vessel development (GO:0001945)	6.10050025
3	angiogenesis involved in wound healing (GO:0060055)	5.67489645
4	Notch signaling involved in heart development (GO:0061314)	5.66352259
5	endothelium development (GO:0003158)	5.42602187
6	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	5.23852616
7	glomerular visceral epithelial cell development (GO:0072015)	5.21810615
8	ventricular trabecula myocardium morphogenesis (GO:0003222)	5.10910032
9	retina vasculature morphogenesis in camera-type eye (GO:0061299)	4.89070511
10	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	4.81626254
11	lymphangiogenesis (GO:0001946)	4.59271030
12	glomerular epithelial cell development (GO:0072310)	4.58584520
13	heart trabecula morphogenesis (GO:0061384)	4.48857869
14	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.44145678
15	glomerular basement membrane development (GO:0032836)	4.42009007
16	cell migration involved in sprouting angiogenesis (GO:0002042)	4.30016787
17	positive regulation of protein kinase C signaling (GO:0090037)	4.26423264
18	surfactant homeostasis (GO:0043129)	4.19919482
19	trabecula morphogenesis (GO:0061383)	4.12608501
20	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	4.05890156
21	positive regulation of vasculogenesis (GO:2001214)	4.02211657
22	hyaluronan catabolic process (GO:0030214)	3.98425209
23	blood vessel endothelial cell migration (GO:0043534)	3.96421212
24	regulation of blood vessel endothelial cell migration (GO:0043535)	3.96145026
25	positive regulation of endothelial cell differentiation (GO:0045603)	3.92916919
26	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	3.85574937
27	blood vessel maturation (GO:0001955)	3.78863070
28	lysine metabolic process (GO:0006553)	3.73340866
29	lysine catabolic process (GO:0006554)	3.73340866
30	patterning of blood vessels (GO:0001569)	3.72231050
31	fatty acid transmembrane transport (GO:1902001)	3.68064936
32	cardiac myofibril assembly (GO:0055003)	3.65411049
33	heart trabecula formation (GO:0060347)	3.63374088
34	basement membrane organization (GO:0071711)	3.63253268
35	transcytosis (GO:0045056)	3.61346246
36	gap junction assembly (GO:0016264)	3.53347295
37	heart valve formation (GO:0003188)	3.50594482
38	semaphorin-plexin signaling pathway (GO:0071526)	3.48758236
39	negative regulation of epithelial cell migration (GO:0010633)	3.48612630
40	renal filtration (GO:0097205)	3.45882012
41	wound healing, spreading of epidermal cells (GO:0035313)	3.41877313
42	endothelial cell morphogenesis (GO:0001886)	3.41011778
43	regulation of vasculogenesis (GO:2001212)	3.38593352
44	chemical homeostasis within a tissue (GO:0048875)	3.38367019
45	venous blood vessel morphogenesis (GO:0048845)	3.38176927
46	glomerular filtration (GO:0003094)	3.37263534
47	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.35781023
48	L-phenylalanine catabolic process (GO:0006559)	3.35781023
49	Notch receptor processing (GO:0007220)	3.35098281
50	negative regulation of angiogenesis (GO:0016525)	3.35024266
51	glyoxylate metabolic process (GO:0046487)	3.34156705
52	endothelial cell proliferation (GO:0001935)	3.32701750
53	regulation of endothelial cell migration (GO:0010594)	3.31405814
54	coronary vasculature morphogenesis (GO:0060977)	3.31146417
55	negative regulation of fibrinolysis (GO:0051918)	3.30706726
56	L-phenylalanine metabolic process (GO:0006558)	3.29792231
57	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.29792231
58	establishment of endothelial barrier (GO:0061028)	3.28464295
59	regulation of endothelial cell differentiation (GO:0045601)	3.28110250
60	plasma membrane repair (GO:0001778)	3.27863256
61	adenosine receptor signaling pathway (GO:0001973)	3.27648001
62	sprouting angiogenesis (GO:0002040)	3.23886097
63	carnitine shuttle (GO:0006853)	3.23215046
64	negative regulation of blood vessel morphogenesis (GO:2000181)	3.21078238
65	nephron epithelium development (GO:0072009)	3.14581121
66	sarcomere organization (GO:0045214)	3.14300770
67	regulation of fibrinolysis (GO:0051917)	3.12426665
68	endothelial cell chemotaxis (GO:0035767)	3.12026972
69	regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)	3.11056857
70	positive regulation of odontogenesis (GO:0042482)	3.10394223
71	angiogenesis (GO:0001525)	3.09911603
72	alpha-linolenic acid metabolic process (GO:0036109)	3.09062820
73	mRNA transcription from RNA polymerase II promoter (GO:0042789)	3.08511904
74	myofibril assembly (GO:0030239)	3.06909564
75	protein localization to endosome (GO:0036010)	3.06378854
76	morphogenesis of an endothelium (GO:0003159)	3.04358738
77	endothelial tube morphogenesis (GO:0061154)	3.04358738
78	glomerulus development (GO:0032835)	3.02556477
79	negative regulation of vasculature development (GO:1901343)	3.01409385
80	cAMP biosynthetic process (GO:0006171)	2.99910484
81	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.98897892
82	fatty acid beta-oxidation (GO:0006635)	2.98473450
83	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.98135524
84	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.97144733
85	aorta morphogenesis (GO:0035909)	2.97014302
86	phospholipid homeostasis (GO:0055091)	2.96439701
87	kynurenine metabolic process (GO:0070189)	2.95609430
88	2-oxoglutarate metabolic process (GO:0006103)	2.95092561
89	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.94499682
90	axon extension involved in axon guidance (GO:0048846)	2.94499682
91	regulation of protein activation cascade (GO:2000257)	2.94254736
92	endothelial cell differentiation (GO:0045446)	2.93900419
93	peptidyl-glutamic acid carboxylation (GO:0017187)	2.90674147
94	protein carboxylation (GO:0018214)	2.90674147
95	aromatic amino acid family catabolic process (GO:0009074)	2.90572749
96	protein kinase C signaling (GO:0070528)	2.89585950
97	endothelial cell migration (GO:0043542)	2.89352633
98	positive regulation of Rap GTPase activity (GO:0032854)	2.85606458
99	aspartate family amino acid catabolic process (GO:0009068)	2.84386531
100	negative regulation of Rho protein signal transduction (GO:0035024)	2.84275969
101	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.84089930
102	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.83847009
103	positive regulation of urine volume (GO:0035810)	2.83736259
104	regulation of complement activation (GO:0030449)	2.83636835
105	ovulation from ovarian follicle (GO:0001542)	2.81529544
106	negative regulation of blood vessel endothelial cell migration (GO:0043537)	2.81447391
107	vasculogenesis (GO:0001570)	2.80386967
108	negative regulation of hemostasis (GO:1900047)	2.79557697
109	negative regulation of blood coagulation (GO:0030195)	2.79557697
110	positive regulation of fatty acid oxidation (GO:0046321)	2.79254788
111	high-density lipoprotein particle remodeling (GO:0034375)	2.79105665
112	fatty acid oxidation (GO:0019395)	2.77420509
113	regulation of triglyceride catabolic process (GO:0010896)	2.77104031
114	regulation of sequestering of triglyceride (GO:0010889)	2.76275313
115	positive regulation of endothelial cell proliferation (GO:0001938)	2.75027765
116	positive regulation of receptor recycling (GO:0001921)	2.72519910
117	negative regulation of focal adhesion assembly (GO:0051895)	2.71065105
118	negative regulation of cell junction assembly (GO:1901889)	2.71065105
119	negative regulation of adherens junction organization (GO:1903392)	2.71065105
120	amino-acid betaine metabolic process (GO:0006577)	2.70927939
121	lipid oxidation (GO:0034440)	2.70735795
122	blood vessel remodeling (GO:0001974)	2.70149290
123	cellular ketone body metabolic process (GO:0046950)	2.69179964
124	negative regulation of platelet activation (GO:0010544)	2.68933527
125	low-density lipoprotein particle clearance (GO:0034383)	2.66727774
126	plasma lipoprotein particle clearance (GO:0034381)	2.66616894
127	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.65756764
128	negative regulation of endothelial cell migration (GO:0010596)	2.65607733
129	substrate-dependent cell migration (GO:0006929)	2.65515198
130	artery development (GO:0060840)	2.65061614
131	positive regulation of endothelial cell migration (GO:0010595)	2.64694989
132	blood vessel morphogenesis (GO:0048514)	2.64657281
133	bile acid biosynthetic process (GO:0006699)	2.64656747
134	triglyceride homeostasis (GO:0070328)	2.64473557
135	acylglycerol homeostasis (GO:0055090)	2.64473557
136	acetyl-CoA metabolic process (GO:0006084)	2.64062772
137	regulation of fatty acid oxidation (GO:0046320)	2.63883497
138	embryonic heart tube development (GO:0035050)	2.63816259
139	cell adhesion mediated by integrin (GO:0033627)	2.63810906
140	cell migration involved in heart development (GO:0060973)	2.63014463
141	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	2.62358436
142	regulation of vascular permeability (GO:0043114)	2.62299005
143	negative regulation of vascular permeability (GO:0043116)	2.61625194
144	Rap protein signal transduction (GO:0032486)	2.61570305
145	mRNA transcription (GO:0009299)	2.60482100
146	regulation of epithelial cell migration (GO:0010632)	2.60351485
147	neuron remodeling (GO:0016322)	2.58650815
148	regulation of angiogenesis (GO:0045765)	2.49714453
149	regulation of synapse maturation (GO:0090128)	2.47709649
150	ganglion development (GO:0061548)	2.47350825
151	positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)	2.46487750
152	atrioventricular valve morphogenesis (GO:0003181)	2.46427809
153	negative regulation of endothelial cell apoptotic process (GO:2000352)	2.43701622
154	endocardial cushion morphogenesis (GO:0003203)	2.42788245
155	regulation of vasculature development (GO:1901342)	2.42250094
156	endothelial cell development (GO:0001885)	2.39653334
157	positive regulation of adherens junction organization (GO:1903393)	2.37408569
158	regulation of endothelial cell proliferation (GO:0001936)	2.37082927
159	positive regulation of cell junction assembly (GO:1901890)	2.36446585

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.92535892
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.17659410
3	* RXR_22158963_ChIP-Seq_LIVER_Mouse	4.05221452
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.69268906
5	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.60730124
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.02788688
7	CLOCK_20551151_ChIP-Seq_293T_Human	3.00139859
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.94482777
9	* NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.75785281
10	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.64413342
11	GATA2_21666600_ChIP-Seq_HMVEC_Human	2.63526790
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.40062651
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.18917155
14	ZNF263_19887448_ChIP-Seq_K562_Human	2.14378284
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.13217393
16	* TBX20_22080862_ChIP-Seq_HEART_Mouse	2.01459279
17	* TBX20_22328084_ChIP-Seq_HEART_Mouse	2.01459279
18	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.96119486
19	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.95643678
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.90053024
21	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.86477491
22	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.79607867
23	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.76061314
24	GATA1_22025678_ChIP-Seq_K562_Human	1.72417058
25	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.70505995
26	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.67861660
27	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.66880349
28	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.65254380
29	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.60657998
30	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.57716929
31	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.57102950
32	DROSHA_22980978_ChIP-Seq_HELA_Human	1.54968213
33	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.54042029
34	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.53984439
35	KDM2B_26808549_Chip-Seq_DND41_Human	1.53359423
36	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.48550320
37	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.44018010
38	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.41373724
39	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.41175529
40	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.39761365
41	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.37307819
42	SCL_19346495_ChIP-Seq_HPC-7_Human	1.34646175
43	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.33925117
44	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33410664
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33279005
46	GATA1_19941826_ChIP-Seq_K562_Human	1.32783630
47	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.32168549
48	CTCF_27219007_Chip-Seq_Bcells_Human	1.30851013
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30174261
50	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.28679192
51	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.28268646
52	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.28199797
53	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.27033071
54	TCF7_22412390_ChIP-Seq_EML_Mouse	1.23520687
55	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.23050883
56	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.22585889
57	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22541478
58	CJUN_26792858_Chip-Seq_BT549_Human	1.20380377
59	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.18784440
60	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.17987043
61	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17159215
62	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.16330286
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.14737172
64	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.14612475
65	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.14478915
66	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.11324093
67	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.10932934
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09665316
69	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.08859254
70	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.07887617
71	SPI1_23127762_ChIP-Seq_K562_Human	1.06025113
72	AHR_22903824_ChIP-Seq_MCF-7_Human	1.05121881
73	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.04491235
74	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.04367949
75	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.03359409
76	* SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.03178355
77	VDR_21846776_ChIP-Seq_THP-1_Human	1.02458481
78	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00375461
79	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99123338
80	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99123338
81	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98973556
82	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.98825770
83	* SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.98597140
84	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.98472150
85	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.97721536
86	SOX2_20726797_ChIP-Seq_SW620_Human	0.97571684
87	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.96963332
88	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.96842527
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96167958
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95926613
91	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.95764756
92	* GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.95626319
93	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.95197328
94	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.95079656
95	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94610827
96	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.94220034
97	RUNX_20019798_ChIP-Seq_JUKART_Human	0.94197486
98	GATA2_19941826_ChIP-Seq_K562_Human	0.93822236
99	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.93776552
100	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93011552
101	TP53_22127205_ChIP-Seq_IMR90_Human	0.92629776
102	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.91658093
103	* TP53_23651856_ChIP-Seq_MEFs_Mouse	0.91397498
104	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.90773664
105	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.90773664
106	* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.89718322
107	VDR_24763502_ChIP-Seq_THP-1_Human	0.89577101
108	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.89573697
109	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.88259993
110	GATA4_25053715_ChIP-Seq_YYC3_Human	0.87578269
111	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.87187690
112	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.85560404
113	LXR_22292898_ChIP-Seq_THP-1_Human	0.85408968
114	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.85405257
115	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.85294388
116	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.85271280
117	KDM2B_26808549_Chip-Seq_K562_Human	0.85199342
118	SMC4_20622854_ChIP-Seq_HELA_Human	0.85014084
119	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.84793009
120	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.84686152
121	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.83714798
122	* P68_20966046_ChIP-Seq_HELA_Human	0.83613398
123	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.82395113
124	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.81899497
125	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.81695891
126	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.81594993
127	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.81524710
128	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.81381155
129	BCAT_22108803_ChIP-Seq_LS180_Human	0.81274153
130	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.81187200
131	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.80733055
132	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.80582913
133	RACK7_27058665_Chip-Seq_MCF-7_Human	0.80089284
134	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.79350048
135	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.79144859
136	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.78924420
137	* NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.78793285
138	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.78144907
139	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.78036336
140	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.77233094
141	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.76859967
142	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.76501382
143	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.74857329
144	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.74180088
145	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.73799210
146	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.73708286
147	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.73650450

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	6.55221757
2	MP0001879_abnormal_lymphatic_vessel	4.68008376
3	MP0004272_abnormal_basement_membrane	4.50866701
4	MP0004084_abnormal_cardiac_muscle	3.75818540
5	MP0005360_urolithiasis	3.40538812
6	MP0005409_darkened_coat_color	2.99683806
7	MP0002139_abnormal_hepatobiliary_system	2.95578401
8	MP0005167_abnormal_blood-brain_barrier	2.95265401
9	MP0002837_dystrophic_cardiac_calcinosis	2.86995098
10	MP0004215_abnormal_myocardial_fiber	2.72205601
11	MP0005085_abnormal_gallbladder_physiolo	2.66460545
12	MP0004036_abnormal_muscle_relaxation	2.55152898
13	MP0000465_gastrointestinal_hemorrhage	2.54317278
14	MP0005365_abnormal_bile_salt	2.38682079
15	MP0003705_abnormal_hypodermis_morpholog	2.15076818
16	MP0006138_congestive_heart_failure	2.08755134
17	MP0005330_cardiomyopathy	2.07869559
18	MP0003828_pulmonary_edema	2.06287164
19	MP0000751_myopathy	2.06174462
20	MP0004130_abnormal_muscle_cell	1.92230826
21	MP0008775_abnormal_heart_ventricle	1.90197107
22	MP0003724_increased_susceptibility_to	1.83741361
23	MP0003252_abnormal_bile_duct	1.83467034
24	MP0002972_abnormal_cardiac_muscle	1.81115815
25	MP0001544_abnormal_cardiovascular_syste	1.78992549
26	MP0005385_cardiovascular_system_phenoty	1.78992549
27	MP0002138_abnormal_hepatobiliary_system	1.76604674
28	MP0008875_abnormal_xenobiotic_pharmacok	1.76244972
29	MP0010630_abnormal_cardiac_muscle	1.72343686
30	MP0000013_abnormal_adipose_tissue	1.72031166
31	MP0006054_spinal_hemorrhage	1.71278987
32	MP0003279_aneurysm	1.69867875
33	MP0010329_abnormal_lipoprotein_level	1.67839334
34	MP0000767_abnormal_smooth_muscle	1.61208947
35	MP0004782_abnormal_surfactant_physiolog	1.59516515
36	MP0005165_increased_susceptibility_to	1.55217857
37	MP0004085_abnormal_heartbeat	1.47955376
38	MP0005620_abnormal_muscle_contractility	1.47803457
39	MP0005623_abnormal_meninges_morphology	1.46628425
40	MP0004484_altered_response_of	1.46079755
41	MP0004087_abnormal_muscle_fiber	1.45499178
42	MP0002933_joint_inflammation	1.44867029
43	MP0002332_abnormal_exercise_endurance	1.44099446
44	MP0005332_abnormal_amino_acid	1.41571294
45	MP0002127_abnormal_cardiovascular_syste	1.41540913
46	MP0003566_abnormal_cell_adhesion	1.40485641
47	MP0002128_abnormal_blood_circulation	1.40129781
48	MP0005670_abnormal_white_adipose	1.36068430
49	MP0000749_muscle_degeneration	1.33102830
50	MP0000230_abnormal_systemic_arterial	1.26542995
51	MP0003646_muscle_fatigue	1.22129080
52	MP0003191_abnormal_cellular_cholesterol	1.17528258
53	MP0000750_abnormal_muscle_regeneration	1.16689012
54	MP0005595_abnormal_vascular_smooth	1.15730394
55	MP0005275_abnormal_skin_tensile	1.15424965
56	MP0002295_abnormal_pulmonary_circulatio	1.15349132
57	MP0004147_increased_porphyrin_level	1.13871070
58	MP0005083_abnormal_biliary_tract	1.08962971
59	MP0003300_gastrointestinal_ulcer	1.07971660
60	MP0000343_altered_response_to	1.07862500
61	MP0003806_abnormal_nucleotide_metabolis	1.07677835
62	MP0003137_abnormal_impulse_conducting	1.06654698
63	MP0005319_abnormal_enzyme/_coenzyme	1.06564702
64	MP0001614_abnormal_blood_vessel	1.04861944
65	MP0000249_abnormal_blood_vessel	1.04722145
66	MP0005666_abnormal_adipose_tissue	1.04267441
67	MP0009643_abnormal_urine_homeostasis	1.03677326
68	MP0004510_myositis	1.03219211
69	MP0002925_abnormal_cardiovascular_devel	1.01544674
70	MP0000003_abnormal_adipose_tissue	1.00206646
71	MP0000266_abnormal_heart_morphology	0.99030453
72	MP0005187_abnormal_penis_morphology	0.98862064
73	MP0002118_abnormal_lipid_homeostasis	0.98231086
74	MP0005503_abnormal_tendon_morphology	0.97208354
75	MP0000609_abnormal_liver_physiology	0.93784852
76	MP0001661_extended_life_span	0.91658355
77	MP0004185_abnormal_adipocyte_glucose	0.90716307
78	MP0009840_abnormal_foam_cell	0.90602294
79	MP0005375_adipose_tissue_phenotype	0.90556047
80	MP0001849_ear_inflammation	0.86514548
81	MP0002269_muscular_atrophy	0.85853618
82	MP0002106_abnormal_muscle_physiology	0.83649129
83	MP0008438_abnormal_cutaneous_collagen	0.81638917
84	MP0001915_intracranial_hemorrhage	0.81390471
85	MP0009697_abnormal_copulation	0.79805415
86	MP0001756_abnormal_urination	0.79056063
87	MP0001666_abnormal_nutrient_absorption	0.77768290
88	MP0003567_abnormal_fetal_cardiomyocyte	0.77304659
89	MP0001958_emphysema	0.74515303
90	MP0002133_abnormal_respiratory_system	0.74321032
91	MP0005388_respiratory_system_phenotype	0.74321032
92	MP0005084_abnormal_gallbladder_morpholo	0.74311307
93	MP0002108_abnormal_muscle_morphology	0.73365547
94	MP0003195_calcinosis	0.71029813
95	MP0003091_abnormal_cell_migration	0.70395728
96	MP0001986_abnormal_taste_sensitivity	0.70381821
97	MP0001784_abnormal_fluid_regulation	0.68219986
98	MP0003950_abnormal_plasma_membrane	0.66997669
99	MP0005369_muscle_phenotype	0.66133241
100	MP0002998_abnormal_bone_remodeling	0.65781246
101	MP0003948_abnormal_gas_homeostasis	0.65458471
102	MP0005164_abnormal_response_to	0.63491948
103	MP0000747_muscle_weakness	0.62850114
104	MP0003221_abnormal_cardiomyocyte_apopto	0.62530016
105	MP0004019_abnormal_vitamin_homeostasis	0.61760666
106	MP0000759_abnormal_skeletal_muscle	0.60961788
107	MP0005023_abnormal_wound_healing	0.60827508
108	MP0009780_abnormal_chondrocyte_physiolo	0.60799093
109	MP0002136_abnormal_kidney_physiology	0.60728056
110	MP0005058_abnormal_lysosome_morphology	0.60071439
111	MP0000598_abnormal_liver_morphology	0.59382968
112	MP0002971_abnormal_brown_adipose	0.57835276
113	MP0009384_cardiac_valve_regurgitation	0.57228335
114	MP0004145_abnormal_muscle_electrophysio	0.56387088
115	MP0003303_peritoneal_inflammation	0.56149996
116	MP0005584_abnormal_enzyme/coenzyme_acti	0.54873098
117	MP0002896_abnormal_bone_mineralization	0.53362482
118	MP0001533_abnormal_skeleton_physiology	0.52044612
119	MP0002638_abnormal_pupillary_reflex	0.50917195
120	MP0003045_fibrosis	0.47775878
121	MP0000733_abnormal_muscle_development	0.46919085
122	MP0002877_abnormal_melanocyte_morpholog	0.45529714
123	MP0008874_decreased_physiological_sensi	0.45139855
124	MP0002086_abnormal_extraembryonic_tissu	0.44683123
125	MP0005508_abnormal_skeleton_morphology	0.44623572
126	MP0008004_abnormal_stomach_pH	0.43548010
127	MP0005451_abnormal_body_composition	0.41476520
128	MP0003943_abnormal_hepatobiliary_system	0.40891149
129	MP0001175_abnormal_lung_morphology	0.39858526
130	MP0003638_abnormal_response/metabolism_	0.38045890
131	MP0003935_abnormal_craniofacial_develop	0.37460118
132	MP0004883_abnormal_blood_vessel	0.36097689
133	MP0005390_skeleton_phenotype	0.35545512
134	MP0003283_abnormal_digestive_organ	0.35058040

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	5.28152129
2	Polycythemia (HP:0001901)	4.85883638
3	Sudden death (HP:0001699)	4.58811644
4	Ventricular tachycardia (HP:0004756)	4.49036767
5	Hemiplegia (HP:0002301)	4.12429449
6	Lymphangioma (HP:0100764)	4.08725407
7	Muscle fiber splitting (HP:0003555)	3.96204827
8	Right ventricular cardiomyopathy (HP:0011663)	3.95062736
9	Esophageal varix (HP:0002040)	3.88614335
10	Porencephaly (HP:0002132)	3.84916832
11	Hyporeflexia of lower limbs (HP:0002600)	3.74309773
12	Adactyly (HP:0009776)	3.70706754
13	Tetraparesis (HP:0002273)	3.63701779
14	Hematochezia (HP:0002573)	3.60578389
15	Capillary hemangiomas (HP:0005306)	3.52257108
16	Hypoglycemic coma (HP:0001325)	3.50736755
17	Spontaneous hematomas (HP:0007420)	3.49807031
18	Mesangial abnormality (HP:0001966)	3.45208985
19	Intrahepatic cholestasis (HP:0001406)	3.45151461
20	Skull defect (HP:0001362)	3.41611202
21	Atrial fibrillation (HP:0005110)	3.40159979
22	Increased connective tissue (HP:0009025)	3.26553479
23	Xanthomatosis (HP:0000991)	3.25759399
24	Abnormality of the hepatic vasculature (HP:0006707)	3.24983279
25	Broad metatarsal (HP:0001783)	3.24607816
26	Supraventricular arrhythmia (HP:0005115)	3.19150513
27	Cerebral hemorrhage (HP:0001342)	3.17658727
28	Arterial tortuosity (HP:0005116)	3.13746965
29	Primary atrial arrhythmia (HP:0001692)	3.11669124
30	Focal segmental glomerulosclerosis (HP:0000097)	3.08075121
31	Visceral angiomatosis (HP:0100761)	3.07921355
32	Lipoatrophy (HP:0100578)	3.06960871
33	Wrist flexion contracture (HP:0001239)	3.06845207
34	Nonimmune hydrops fetalis (HP:0001790)	3.06026322
35	Hypoalphalipoproteinemia (HP:0003233)	3.00215793
36	Absent hand (HP:0004050)	2.99197399
37	Prolonged partial thromboplastin time (HP:0003645)	2.96493369
38	Ketoacidosis (HP:0001993)	2.96298887
39	Atrioventricular block (HP:0001678)	2.95772090
40	Hyperlipoproteinemia (HP:0010980)	2.94835190
41	Supraventricular tachycardia (HP:0004755)	2.94642323
42	Difficulty running (HP:0009046)	2.94308090
43	Abnormality of skeletal muscle fiber size (HP:0012084)	2.93866695
44	Ketosis (HP:0001946)	2.92103665
45	Hypoplasia of the iris (HP:0007676)	2.87621942
46	Hemangiomatosis (HP:0007461)	2.85943500
47	Hyperammonemia (HP:0001987)	2.84681100
48	Cerebral aneurysm (HP:0004944)	2.84026279
49	Vascular tortuosity (HP:0004948)	2.83387180
50	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.81473462
51	Spinal rigidity (HP:0003306)	2.80118946
52	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.77997103
53	Systemic lupus erythematosus (HP:0002725)	2.73816024
54	Hemorrhage of the eye (HP:0011885)	2.73006207
55	Premature rupture of membranes (HP:0001788)	2.71368984
56	Syncope (HP:0001279)	2.71102801
57	Exercise-induced muscle cramps (HP:0003710)	2.69225205
58	Calf muscle hypertrophy (HP:0008981)	2.69084765
59	Abnormality of fatty-acid metabolism (HP:0004359)	2.68946726
60	Myoglobinuria (HP:0002913)	2.68508081
61	Aortic aneurysm (HP:0004942)	2.67267575
62	Cavernous hemangioma (HP:0001048)	2.64295889
63	Distal arthrogryposis (HP:0005684)	2.59973599
64	Exercise-induced myalgia (HP:0003738)	2.59918622
65	Dilated cardiomyopathy (HP:0001644)	2.59145891
66	Abnormality of the intrinsic pathway (HP:0010989)	2.56717287
67	Hyperglycinuria (HP:0003108)	2.56708563
68	Joint hemorrhage (HP:0005261)	2.55684160
69	Conjunctival telangiectasia (HP:0000524)	2.53005883
70	Hypolipoproteinemia (HP:0010981)	2.52209574
71	Overgrowth (HP:0001548)	2.51716673
72	Glomerulosclerosis (HP:0000096)	2.51263677
73	Heart block (HP:0012722)	2.46861228
74	Aneurysm (HP:0002617)	2.46380283
75	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.41991504
76	Abnormality of the common coagulation pathway (HP:0010990)	2.39815610
77	Complement deficiency (HP:0004431)	2.39720100
78	Nephritis (HP:0000123)	2.38889036
79	Palpitations (HP:0001962)	2.36654845
80	Lymphedema (HP:0001004)	2.35625235
81	Muscle hypertrophy of the lower extremities (HP:0008968)	2.32199352
82	Abnormal atrioventricular conduction (HP:0005150)	2.31035047
83	Round ear (HP:0100830)	2.30253994
84	Venous insufficiency (HP:0005293)	2.29463426
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.28033479
86	Dicarboxylic aciduria (HP:0003215)	2.28033479
87	Abnormality of serine family amino acid metabolism (HP:0010894)	2.25801934
88	Abnormality of glycine metabolism (HP:0010895)	2.25801934
89	Abnormality of complement system (HP:0005339)	2.25150709
90	Neonatal death (HP:0003811)	2.25078133
91	Hypobetalipoproteinemia (HP:0003563)	2.23407678
92	Abnormality of the calf musculature (HP:0001430)	2.22860012
93	EMG: myopathic abnormalities (HP:0003458)	2.22382067
94	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.20583734
95	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.19359182
96	Asymmetric septal hypertrophy (HP:0001670)	2.17511378
97	Cardiovascular calcification (HP:0011915)	2.16546579
98	Abnormality of the ischium (HP:0003174)	2.15591976
99	Joint stiffness (HP:0001387)	2.13185852
100	Pulmonary hypertension (HP:0002092)	2.12952421
101	Hypoplastic ischia (HP:0003175)	2.12902368
102	Hip contracture (HP:0003273)	2.12801869
103	Interstitial pulmonary disease (HP:0006530)	2.12587843
104	Rhabdomyolysis (HP:0003201)	2.11407742
105	Venous abnormality (HP:0002624)	2.10549325
106	Shallow orbits (HP:0000586)	2.10511726
107	Stroke (HP:0001297)	2.10418081
108	Exotropia (HP:0000577)	2.10008089
109	Abnormality of the nasal mucosa (HP:0000433)	2.08255044
110	Vascular calcification (HP:0004934)	2.07551880
111	Prolonged QT interval (HP:0001657)	2.07135457
112	Short 4th metacarpal (HP:0010044)	2.06302427
113	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.06302427
114	Nuclear cataract (HP:0100018)	2.06218086
115	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.05339654
116	Abnormality of the left ventricular outflow tract (HP:0011103)	2.05191323
117	Subaortic stenosis (HP:0001682)	2.05191323
118	Skin nodule (HP:0200036)	2.05150684
119	Epidermoid cyst (HP:0200040)	2.05095632
120	Portal hypertension (HP:0001409)	2.04732981
121	Glomerulonephritis (HP:0000099)	2.03020865
122	Aortic dissection (HP:0002647)	2.02778722
123	Hyperinsulinemic hypoglycemia (HP:0000825)	2.01832741
124	Bundle branch block (HP:0011710)	1.99491685
125	Increased variability in muscle fiber diameter (HP:0003557)	1.99314777
126	Protrusio acetabuli (HP:0003179)	1.98419470
127	Distal lower limb muscle weakness (HP:0009053)	1.97173411
128	Myotonia (HP:0002486)	1.97160118
129	Delayed CNS myelination (HP:0002188)	1.97079774
130	Hyperglycinemia (HP:0002154)	1.95922817
131	Ulnar deviation of the wrist (HP:0003049)	1.95664697
132	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.95255356
133	Ventricular arrhythmia (HP:0004308)	1.94865768
134	Difficulty climbing stairs (HP:0003551)	1.94073136
135	Potter facies (HP:0002009)	1.93679338
136	Facial shape deformation (HP:0011334)	1.93679338
137	Limited hip movement (HP:0008800)	1.93635602
138	Hypercholesterolemia (HP:0003124)	1.90435778
139	Type 1 muscle fiber predominance (HP:0003803)	1.88665586
140	Malignant hyperthermia (HP:0002047)	1.88531045
141	Myocardial infarction (HP:0001658)	1.85891700
142	Abnormal vertebral ossification (HP:0100569)	1.82691459
143	Mask-like facies (HP:0000298)	1.80824740
144	Polygenic inheritance (HP:0010982)	1.80159440
145	Ectopia lentis (HP:0001083)	1.80014254
146	Striae distensae (HP:0001065)	1.74951697
147	Abnormality of the peritoneum (HP:0002585)	1.73273905
148	Rapidly progressive (HP:0003678)	1.71827091
149	Joint contractures involving the joints of the feet (HP:0100492)	1.71514542
150	Flexion contracture of toe (HP:0005830)	1.71514542
151	Absent eyebrow (HP:0002223)	1.70132365
152	Limb dystonia (HP:0002451)	1.70007154
153	Abnormality of the periventricular white matter (HP:0002518)	1.66483637
154	Axonal loss (HP:0003447)	1.66397679
155	Bulbous nose (HP:0000414)	1.64643286

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	8.89749567
2	KDR	7.02321825
3	TGFBR2	3.50402518
4	FES	2.66637058
5	TGFBR1	2.32277241
6	MYLK	2.28755123
7	TTN	2.23400675
8	TRIB3	2.18691116
9	EPHB2	2.15052681
10	PKN2	2.07644210
11	RIPK1	1.97240549
12	BCKDK	1.71438354
13	FGFR4	1.68859562
14	PDGFRA	1.64499564
15	ERN1	1.61418904
16	PTK2B	1.53128784
17	DMPK	1.48741406
18	PTK6	1.40730602
19	PDK2	1.33137448
20	SIK1	1.31334561
21	WNK4	1.29985137
22	EPHB1	1.28023617
23	FER	1.24370344
24	INSRR	1.23966706
25	LATS1	1.19682727
26	NTRK1	1.19326447
27	LMTK2	1.17841450
28	OBSCN	1.17309918
29	PDK3	1.16937499
30	PDK4	1.16937499
31	PHKG1	1.13984415
32	PHKG2	1.13984415
33	FGFR2	1.08976306
34	MAP2K3	1.05538419
35	MAP3K13	1.03537695
36	MAPK12	1.02055180
37	PRKD1	0.98751885
38	MAP3K3	0.97438029
39	ICK	0.94080787
40	GRK1	0.91741696
41	ZAP70	0.91393936
42	MARK2	0.88959130
43	PRKG2	0.86304015
44	MAP4K1	0.82162995
45	FGFR3	0.80372475
46	PRKD3	0.79118804
47	PRKD2	0.78037066
48	PAK3	0.77704021
49	LRRK2	0.76521769
50	PRKAA2	0.76487636
51	RPS6KA2	0.75212345
52	PIK3CG	0.74838584
53	MOS	0.74112450
54	PTK2	0.73660413
55	BLK	0.72116360
56	PIK3CA	0.71679557
57	STK39	0.70812771
58	ARAF	0.69509500
59	MAP3K7	0.68726813
60	MAPK15	0.67661860
61	ROCK1	0.65715621
62	TYRO3	0.64859940
63	MET	0.64436579
64	PAK4	0.63715711
65	PDGFRB	0.63434441
66	RET	0.60325477
67	PRKCH	0.57342537
68	GSK3A	0.56286242
69	EEF2K	0.56249958
70	MAP3K9	0.55471535
71	PDPK1	0.55428130
72	JAK1	0.54972082
73	CAMK4	0.52240476
74	HCK	0.51710537
75	FLT3	0.50578650
76	MAP3K6	0.50524842
77	PAK2	0.49946082
78	CSK	0.48546169
79	MAP3K10	0.48141989
80	JAK3	0.47790245
81	DYRK1B	0.47357646
82	EPHA3	0.47300793
83	NEK9	0.46543464
84	PRKAA1	0.44805945
85	ITK	0.44154494
86	JAK2	0.44015112
87	ROCK2	0.43582087
88	DDR2	0.43188261
89	MAP3K1	0.42873282
90	IGF1R	0.41088741
91	MAPK7	0.40775367
92	ILK	0.39837778
93	MAP3K11	0.39684779
94	MAP2K1	0.38716023
95	KSR2	0.38332766
96	CAMK1D	0.38076355
97	LATS2	0.37859973
98	MTOR	0.37685835
99	SGK2	0.36362220
100	TYK2	0.36296614
101	SGK494	0.36145462
102	SGK223	0.36145462
103	STK10	0.35511471
104	FRK	0.35215024
105	PRKCE	0.35030785
106	SRC	0.34267532
107	EGFR	0.33280351
108	CAMK1G	0.32672140
109	CDC42BPA	0.29990611
110	GRK5	0.29946517
111	SGK3	0.29809538
112	ABL2	0.29594607
113	OXSR1	0.29323770
114	MAPK11	0.29127053
115	FGFR1	0.28783991
116	PRKACG	0.27632998
117	TEC	0.27553803
118	PRKACB	0.27500450
119	LCK	0.27135744
120	AKT2	0.26948565
121	MARK3	0.26784166
122	PDK1	0.26722944
123	AKT3	0.26585507
124	MAP2K4	0.25321474
125	MAPKAPK3	0.25302046
126	TBK1	0.24922867
127	MAP2K2	0.23871830
128	ADRBK1	0.23675029
129	MAPK4	0.22105619
130	KIT	0.22020868
131	TRPM7	0.21192453
132	RPS6KC1	0.20714990
133	RPS6KL1	0.20714990
134	STK24	0.20219229
135	PINK1	0.20213212
136	TNK2	0.19390212
137	ERBB4	0.18985746
138	BMX	0.18408598
139	TESK1	0.16803307
140	LYN	0.15853451
141	RPS6KA6	0.15797877

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.27732166
2	Fatty acid degradation_Homo sapiens_hsa00071	3.00971869
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.92219767
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.73927688
5	Propanoate metabolism_Homo sapiens_hsa00640	2.68308506
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.63979476
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.57574026
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.56576721
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.48218371
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.38864414
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.38779091
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.25735230
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.24991620
14	PPAR signaling pathway_Homo sapiens_hsa03320	2.21226501
15	Fatty acid metabolism_Homo sapiens_hsa01212	2.17035368
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.14955066
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.13468263
18	Butanoate metabolism_Homo sapiens_hsa00650	1.92553027
19	Prion diseases_Homo sapiens_hsa05020	1.83915212
20	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.78342569
21	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.78337221
22	ECM-receptor interaction_Homo sapiens_hsa04512	1.76289467
23	Bile secretion_Homo sapiens_hsa04976	1.68034179
24	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.60836084
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.54499059
26	Peroxisome_Homo sapiens_hsa04146	1.45220339
27	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.43767877
28	Malaria_Homo sapiens_hsa05144	1.40604580
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.38610608
30	Focal adhesion_Homo sapiens_hsa04510	1.35210147
31	Pertussis_Homo sapiens_hsa05133	1.34014693
32	Ras signaling pathway_Homo sapiens_hsa04014	1.31883531
33	Other glycan degradation_Homo sapiens_hsa00511	1.31132033
34	Carbon metabolism_Homo sapiens_hsa01200	1.30719198
35	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.30394100
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30055634
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.29474788
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.28564971
39	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.25244046
40	Caffeine metabolism_Homo sapiens_hsa00232	1.22120101
41	Lysine degradation_Homo sapiens_hsa00310	1.21678878
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.21242071
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.20623926
44	Fatty acid elongation_Homo sapiens_hsa00062	1.17146115
45	ABC transporters_Homo sapiens_hsa02010	1.17034216
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.10844811
47	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.10297128
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.07005099
49	Phenylalanine metabolism_Homo sapiens_hsa00360	1.03782627
50	Adherens junction_Homo sapiens_hsa04520	1.01192077
51	GnRH signaling pathway_Homo sapiens_hsa04912	1.00129409
52	Insulin resistance_Homo sapiens_hsa04931	1.00009620
53	Histidine metabolism_Homo sapiens_hsa00340	0.97907364
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97129294
55	Endocytosis_Homo sapiens_hsa04144	0.96614108
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91828170
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.91410180
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87366691
59	Amoebiasis_Homo sapiens_hsa05146	0.87276503
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86903215
61	Estrogen signaling pathway_Homo sapiens_hsa04915	0.86041930
62	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.85202379
63	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.84750659
64	Small cell lung cancer_Homo sapiens_hsa05222	0.83969210
65	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.82988140
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81664202
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80668800
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.80546071
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78892988
70	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.77627314
71	Gap junction_Homo sapiens_hsa04540	0.77496276
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.77433040
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77155410
74	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.76986374
75	Pathways in cancer_Homo sapiens_hsa05200	0.75523103
76	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.75415722
77	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.74982608
78	Retinol metabolism_Homo sapiens_hsa00830	0.74486037
79	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.73410651
80	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.72652931
81	Protein digestion and absorption_Homo sapiens_hsa04974	0.71993417
82	Lysosome_Homo sapiens_hsa04142	0.71504023
83	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70705543
84	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.68817481
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.67785852
86	Gastric acid secretion_Homo sapiens_hsa04971	0.67101127
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.67072068
88	Osteoclast differentiation_Homo sapiens_hsa04380	0.66569492
89	MAPK signaling pathway_Homo sapiens_hsa04010	0.65505132
90	Glioma_Homo sapiens_hsa05214	0.64945744
91	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.64940380
92	Viral myocarditis_Homo sapiens_hsa05416	0.64689169
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63507329
94	Rap1 signaling pathway_Homo sapiens_hsa04015	0.62365720
95	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.62240683
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.61675134
97	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60210159
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59528088
99	Pancreatic cancer_Homo sapiens_hsa05212	0.59397647
100	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.57779681
101	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57451177
102	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56683857
103	Sulfur metabolism_Homo sapiens_hsa00920	0.56204530
104	Tight junction_Homo sapiens_hsa04530	0.55488233
105	Leishmaniasis_Homo sapiens_hsa05140	0.55292307
106	Prolactin signaling pathway_Homo sapiens_hsa04917	0.55029774
107	Chemokine signaling pathway_Homo sapiens_hsa04062	0.54458535
108	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53422240
109	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.52739103
110	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52344375
111	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51739706
112	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.51577714
113	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51209706
114	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.51097599
115	Proteoglycans in cancer_Homo sapiens_hsa05205	0.50518531
116	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.49723935
117	Phagosome_Homo sapiens_hsa04145	0.49670904
118	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49459652
119	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48206018
120	Salmonella infection_Homo sapiens_hsa05132	0.47394695
121	Melanogenesis_Homo sapiens_hsa04916	0.46838768
122	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46418293
123	mTOR signaling pathway_Homo sapiens_hsa04150	0.45965565
124	Calcium signaling pathway_Homo sapiens_hsa04020	0.45842405
125	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.45762822
126	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45438042
127	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45351297
128	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45320992
129	Long-term potentiation_Homo sapiens_hsa04720	0.45296106
130	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.44861485
131	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44688991
132	MicroRNAs in cancer_Homo sapiens_hsa05206	0.44336833
133	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43770467
134	Notch signaling pathway_Homo sapiens_hsa04330	0.43352881
135	Glucagon signaling pathway_Homo sapiens_hsa04922	0.43277978
136	Platelet activation_Homo sapiens_hsa04611	0.42952324
137	Morphine addiction_Homo sapiens_hsa05032	0.42504049
138	Rheumatoid arthritis_Homo sapiens_hsa05323	0.42371083
139	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42102740
140	FoxO signaling pathway_Homo sapiens_hsa04068	0.41465654
141	Long-term depression_Homo sapiens_hsa04730	0.41214467
142	Axon guidance_Homo sapiens_hsa04360	0.40884574
143	Bladder cancer_Homo sapiens_hsa05219	0.40258124
144	AMPK signaling pathway_Homo sapiens_hsa04152	0.39334295
145	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.37901386
146	VEGF signaling pathway_Homo sapiens_hsa04370	0.35526382
147	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35495456
148	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34928402
149	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32489710
150	Renin secretion_Homo sapiens_hsa04924	0.31587433
151	Renin-angiotensin system_Homo sapiens_hsa04614	0.31458531
152	Renal cell carcinoma_Homo sapiens_hsa05211	0.30302897
153	Insulin signaling pathway_Homo sapiens_hsa04910	0.29137755
154	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28845413
155	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.25499289
156	Toxoplasmosis_Homo sapiens_hsa05145	0.24853415
157	African trypanosomiasis_Homo sapiens_hsa05143	0.24834887
158	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.23754104
159	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.22849163
160	Folate biosynthesis_Homo sapiens_hsa00790	0.21581747

PCDH12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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