PCDH15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)9.61256033
2regulation of rhodopsin mediated signaling pathway (GO:0022400)9.49976391
3rhodopsin mediated signaling pathway (GO:0016056)9.36128504
4detection of light stimulus involved in sensory perception (GO:0050962)7.60817807
5detection of light stimulus involved in visual perception (GO:0050908)7.60817807
6photoreceptor cell development (GO:0042461)7.45569862
7eye photoreceptor cell development (GO:0042462)7.26841512
8* photoreceptor cell maintenance (GO:0045494)6.64337305
9retinal rod cell development (GO:0046548)6.57985400
10protein-chromophore linkage (GO:0018298)6.30244379
11phototransduction (GO:0007602)5.90510398
12detection of light stimulus (GO:0009583)5.78297207
13detection of visible light (GO:0009584)5.76362090
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.68593509
15phototransduction, visible light (GO:0007603)5.68386070
16neuron cell-cell adhesion (GO:0007158)5.49824277
17* visual perception (GO:0007601)5.21103380
18* sensory perception of light stimulus (GO:0050953)5.16642036
19positive regulation of guanylate cyclase activity (GO:0031284)5.10487276
20presynaptic membrane assembly (GO:0097105)4.96838849
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91033748
22eye photoreceptor cell differentiation (GO:0001754)4.87693737
23photoreceptor cell differentiation (GO:0046530)4.87693737
24protein localization to synapse (GO:0035418)4.58209811
25postsynaptic membrane organization (GO:0001941)4.52246002
26regulation of guanylate cyclase activity (GO:0031282)4.49847788
27neurotransmitter-gated ion channel clustering (GO:0072578)4.37336739
28GMP metabolic process (GO:0046037)4.36962489
29presynaptic membrane organization (GO:0097090)4.32274344
30regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31561423
31* detection of external stimulus (GO:0009581)4.25011623
32* detection of abiotic stimulus (GO:0009582)4.20004769
33regulation of axon regeneration (GO:0048679)4.17962554
34regulation of neuron projection regeneration (GO:0070570)4.17962554
35locomotory exploration behavior (GO:0035641)4.13286355
36regulation of meiosis I (GO:0060631)4.07898828
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03987848
38retina development in camera-type eye (GO:0060041)3.95096004
39vocalization behavior (GO:0071625)3.91008538
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87660618
41cellular response to light stimulus (GO:0071482)3.71352672
42membrane hyperpolarization (GO:0060081)3.70438647
43mechanosensory behavior (GO:0007638)3.63211995
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.60256752
45neuronal action potential propagation (GO:0019227)3.57305832
46regulation of synaptic vesicle exocytosis (GO:2000300)3.56209412
47axon ensheathment in central nervous system (GO:0032291)3.55342243
48central nervous system myelination (GO:0022010)3.55342243
49regulation of voltage-gated calcium channel activity (GO:1901385)3.55327613
50pyrimidine nucleobase catabolic process (GO:0006208)3.55187788
51retina layer formation (GO:0010842)3.50680432
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45110713
53synaptic vesicle exocytosis (GO:0016079)3.44612079
54auditory behavior (GO:0031223)3.44298516
55regulation of glutamate receptor signaling pathway (GO:1900449)3.41470519
56phosphorelay signal transduction system (GO:0000160)3.41093264
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.39086837
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38029560
59regulation of cGMP metabolic process (GO:0030823)3.35609233
60gamma-aminobutyric acid transport (GO:0015812)3.34068356
61synaptic vesicle maturation (GO:0016188)3.33101726
62membrane assembly (GO:0071709)3.32840864
63positive regulation of membrane potential (GO:0045838)3.30557999
64positive regulation of cGMP biosynthetic process (GO:0030828)3.30304094
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23657443
66synapse assembly (GO:0007416)3.21021775
67behavioral response to ethanol (GO:0048149)3.19204631
68regulation of collateral sprouting (GO:0048670)3.18020490
69dendritic spine morphogenesis (GO:0060997)3.16092548
70response to histamine (GO:0034776)3.15624307
71negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11242842
72positive regulation of neurotransmitter transport (GO:0051590)3.09961303
73neuron recognition (GO:0008038)3.09826365
74long-term synaptic potentiation (GO:0060291)3.08649397
75cAMP catabolic process (GO:0006198)3.06877876
76regulation of synaptic vesicle transport (GO:1902803)3.05651446
77limb bud formation (GO:0060174)3.04457585
78dermatan sulfate biosynthetic process (GO:0030208)3.04319493
79cellular potassium ion homeostasis (GO:0030007)3.03696490
80axonal fasciculation (GO:0007413)3.03298877
81regulation of cGMP biosynthetic process (GO:0030826)3.03256806
82innervation (GO:0060384)3.02196675
83glutamate secretion (GO:0014047)3.01118957
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00847820
85positive regulation of meiosis (GO:0045836)2.98857617
86central nervous system projection neuron axonogenesis (GO:0021952)2.97827187
87regulation of respiratory system process (GO:0044065)2.96366113
88negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.96102157
89regulation of neurotransmitter secretion (GO:0046928)2.95960706
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94086775
91response to pheromone (GO:0019236)2.93899170
92estrogen biosynthetic process (GO:0006703)2.93393697
93oligodendrocyte differentiation (GO:0048709)2.93383481
94cyclic nucleotide catabolic process (GO:0009214)2.92631161
95positive regulation of synapse assembly (GO:0051965)2.90819273
96regulation of postsynaptic membrane potential (GO:0060078)2.90745230
97nucleobase catabolic process (GO:0046113)2.90107392
98neuron-neuron synaptic transmission (GO:0007270)2.89957994
99* sensory perception (GO:0007600)2.89467320
100synaptic transmission, glutamatergic (GO:0035249)2.88830383
101regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.88765221
102positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.87562628
103neuronal action potential (GO:0019228)2.86116006
104short-term memory (GO:0007614)2.86111165
105detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.84554535
106astrocyte differentiation (GO:0048708)2.83722895
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82390343
108positive regulation of cGMP metabolic process (GO:0030825)2.82347569
109protein K11-linked deubiquitination (GO:0035871)2.82288636
110peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82238471
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.81134252
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.78041650
113regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78017799
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77966211
115glutamate receptor signaling pathway (GO:0007215)2.77326440
116positive regulation of meiotic cell cycle (GO:0051446)2.77147332
117exploration behavior (GO:0035640)2.76898920
118neuron development (GO:0048666)2.75192207
119amino acid import (GO:0043090)2.74527843
120C4-dicarboxylate transport (GO:0015740)2.73397350
121regulation of clathrin-mediated endocytosis (GO:2000369)2.72946222
122neurotransmitter transport (GO:0006836)2.71757980
123positive regulation of oligodendrocyte differentiation (GO:0048714)2.71753617
124membrane depolarization during action potential (GO:0086010)2.71013058
125dendrite morphogenesis (GO:0048813)2.70775847
126negative regulation of neurotransmitter transport (GO:0051589)2.69837619
127piRNA metabolic process (GO:0034587)2.69329805
128L-amino acid import (GO:0043092)2.68227516
129Sertoli cell development (GO:0060009)2.68135827
130transmission of nerve impulse (GO:0019226)2.67751776
131regulation of neurotransmitter transport (GO:0051588)2.65941717
132positive regulation of neurotransmitter secretion (GO:0001956)2.65904786
133dermatan sulfate metabolic process (GO:0030205)2.65881609
134central nervous system neuron axonogenesis (GO:0021955)2.65635079
135chemosensory behavior (GO:0007635)2.64373323
136calcium ion import (GO:0070509)2.63809336
137limb development (GO:0060173)2.63297103
138appendage development (GO:0048736)2.63297103
139neurotransmitter secretion (GO:0007269)2.62709661
140* nonmotile primary cilium assembly (GO:0035058)2.62326182
141* startle response (GO:0001964)2.61768739
142positive regulation of ERBB signaling pathway (GO:1901186)2.61704537
143establishment of protein localization to Golgi (GO:0072600)2.60226877
144potassium ion homeostasis (GO:0055075)2.59663609
145response to auditory stimulus (GO:0010996)2.58697852
146behavioral response to cocaine (GO:0048148)2.58286636
147behavioral response to nicotine (GO:0035095)2.57471915
148cellular response to sterol (GO:0036315)2.53485404
149positive regulation of neurological system process (GO:0031646)2.52685530
150synapse organization (GO:0050808)2.51149722
151positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.48548128
152action potential (GO:0001508)2.45597908
153negative regulation of neurotransmitter secretion (GO:0046929)2.45253266
154spinal cord motor neuron differentiation (GO:0021522)2.45039537
155microtubule polymerization or depolymerization (GO:0031109)2.44030807
156neural tube formation (GO:0001841)2.43789322
157glycosphingolipid biosynthetic process (GO:0006688)2.43777768
158gamma-aminobutyric acid signaling pathway (GO:0007214)2.43628026
159cerebral cortex radially oriented cell migration (GO:0021799)2.40605323
160negative regulation of axon extension (GO:0030517)2.37482095
161* detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.36820876
162* adult walking behavior (GO:0007628)2.35212105
163cilium or flagellum-dependent cell motility (GO:0001539)2.34080686
164positive regulation of cardiac muscle cell differentiation (GO:2000727)2.33659107
165regulation of timing of cell differentiation (GO:0048505)2.33586582
166negative regulation of inclusion body assembly (GO:0090084)2.32925352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GBX2_23144817_ChIP-Seq_PC3_Human4.09025463
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.49470708
3EZH2_22144423_ChIP-Seq_EOC_Human3.06913213
4AR_21572438_ChIP-Seq_LNCaP_Human2.54771510
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52882763
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50400814
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42824441
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37684861
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.18282163
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14668217
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13405231
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13405231
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10647518
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08746152
15TAF15_26573619_Chip-Seq_HEK293_Human2.06654481
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05181877
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02224755
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02218782
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00080215
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.99908704
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.95334723
22VDR_22108803_ChIP-Seq_LS180_Human1.94208980
23EWS_26573619_Chip-Seq_HEK293_Human1.94149245
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92190412
25DROSHA_22980978_ChIP-Seq_HELA_Human1.90879526
26ZNF274_21170338_ChIP-Seq_K562_Hela1.90784692
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89503539
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87157443
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87152036
30* REST_21632747_ChIP-Seq_MESCs_Mouse1.87021040
31IGF1R_20145208_ChIP-Seq_DFB_Human1.86981537
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85676582
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.82114235
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81474919
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.79788197
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.79521713
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75149274
38P300_19829295_ChIP-Seq_ESCs_Human1.70695396
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67420226
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.67018989
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.65551882
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.65177856
43BCAT_22108803_ChIP-Seq_LS180_Human1.63212193
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61349558
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55010405
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48596750
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46766260
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46319726
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.45411475
50ER_23166858_ChIP-Seq_MCF-7_Human1.45002926
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44813828
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43958618
53* STAT3_23295773_ChIP-Seq_U87_Human1.43273424
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.38422604
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35493587
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35446905
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35420293
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35222863
59FUS_26573619_Chip-Seq_HEK293_Human1.34765673
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33803380
61RNF2_27304074_Chip-Seq_NSC_Mouse1.33636814
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32965327
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32123913
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.31393964
65* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30916630
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28543532
67AR_25329375_ChIP-Seq_VCAP_Human1.27549003
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25583494
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24512800
70* TCF4_23295773_ChIP-Seq_U87_Human1.24033494
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.22561676
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22545029
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21557177
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.21229759
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20978428
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20932588
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20749433
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.20642964
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19908525
80CBP_20019798_ChIP-Seq_JUKART_Human1.19908525
81TP53_16413492_ChIP-PET_HCT116_Human1.19201802
82* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17769690
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17660319
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17660319
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17343832
86TCF4_22108803_ChIP-Seq_LS180_Human1.15341915
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15338702
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14969014
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.14607436
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14147171
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.12467568
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12286683
93* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12212135
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.12089302
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.12072992
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12010893
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11658953
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11149262
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.10368620
100AHR_22903824_ChIP-Seq_MCF-7_Human1.10145894
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.09540726
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.09449706
103P53_22387025_ChIP-Seq_ESCs_Mouse1.09197897
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08012914
105RUNX2_22187159_ChIP-Seq_PCA_Human1.07961574
106* AR_19668381_ChIP-Seq_PC3_Human1.07897826
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07495855
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07454764
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.05267448
110* KDM2B_26808549_Chip-Seq_REH_Human1.04779050
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04509876
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.02890402
113* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02711139
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01989935
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00913408
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.98864332
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98803034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.09039205
2MP0003011_delayed_dark_adaptation6.30093378
3MP0006072_abnormal_retinal_apoptosis4.80618549
4MP0005253_abnormal_eye_physiology4.74621782
5MP0003880_abnormal_central_pattern4.05402650
6MP0005423_abnormal_somatic_nervous3.88129812
7MP0005195_abnormal_posterior_eye2.80802317
8MP0002090_abnormal_vision2.55354820
9MP0003950_abnormal_plasma_membrane2.41926108
10MP0002638_abnormal_pupillary_reflex2.34751119
11* MP0001486_abnormal_startle_reflex2.30414846
12MP0004859_abnormal_synaptic_plasticity2.20281925
13* MP0002229_neurodegeneration2.19698403
14MP0001324_abnormal_eye_pigmentation2.19245016
15MP0004147_increased_porphyrin_level2.18751739
16MP0003635_abnormal_synaptic_transmissio2.15135478
17MP0001984_abnormal_olfaction2.13501570
18MP0005391_vision/eye_phenotype2.12500162
19MP0004270_analgesia2.10491358
20MP0008057_abnormal_DNA_replication2.09927397
21MP0001968_abnormal_touch/_nociception2.07715361
22MP0001502_abnormal_circadian_rhythm2.02176799
23MP0008877_abnormal_DNA_methylation1.96529221
24MP0005646_abnormal_pituitary_gland1.96308066
25MP0005645_abnormal_hypothalamus_physiol1.94889217
26MP0009745_abnormal_behavioral_response1.92407967
27MP0002272_abnormal_nervous_system1.90998727
28MP0006292_abnormal_olfactory_placode1.88432962
29MP0002064_seizures1.88039494
30MP0002734_abnormal_mechanical_nocicepti1.84902881
31MP0001986_abnormal_taste_sensitivity1.81079891
32* MP0002752_abnormal_somatic_nervous1.79146612
33MP0009046_muscle_twitch1.77686582
34MP0002063_abnormal_learning/memory/cond1.72440280
35MP0002572_abnormal_emotion/affect_behav1.71063054
36MP0002736_abnormal_nociception_after1.64370411
37* MP0002882_abnormal_neuron_morphology1.62052763
38MP0003195_calcinosis1.52358655
39MP0003183_abnormal_peptide_metabolism1.52003325
40* MP0002067_abnormal_sensory_capabilities1.50107421
41MP0001485_abnormal_pinna_reflex1.42245055
42MP0002653_abnormal_ependyma_morphology1.39547021
43MP0010386_abnormal_urinary_bladder1.29179108
44MP0000778_abnormal_nervous_system1.25292845
45MP0005386_behavior/neurological_phenoty1.22412547
46MP0004924_abnormal_behavior1.22412547
47MP0004885_abnormal_endolymph1.21783592
48MP0002557_abnormal_social/conspecific_i1.21673395
49MP0003136_yellow_coat_color1.20991614
50MP0000631_abnormal_neuroendocrine_gland1.20724947
51MP0001501_abnormal_sleep_pattern1.19757740
52MP0001188_hyperpigmentation1.19356796
53MP0002184_abnormal_innervation1.18354644
54MP0003634_abnormal_glial_cell1.18258024
55* MP0004742_abnormal_vestibular_system1.12365289
56MP0003172_abnormal_lysosome_physiology1.11518670
57MP0004142_abnormal_muscle_tone1.11260083
58MP0001970_abnormal_pain_threshold1.10782020
59MP0003283_abnormal_digestive_organ1.07862569
60MP0002751_abnormal_autonomic_nervous1.06684427
61MP0003121_genomic_imprinting1.05615528
62MP0006276_abnormal_autonomic_nervous1.04924777
63MP0003119_abnormal_digestive_system1.04223933
64* MP0001963_abnormal_hearing_physiology1.04110757
65MP0004043_abnormal_pH_regulation1.00180422
66MP0000920_abnormal_myelination1.00020626
67MP0005187_abnormal_penis_morphology0.97468423
68MP0002735_abnormal_chemical_nociception0.97002111
69MP0003718_maternal_effect0.96160462
70MP0001529_abnormal_vocalization0.94647746
71MP0008569_lethality_at_weaning0.94017955
72MP0002234_abnormal_pharynx_morphology0.92674303
73MP0002733_abnormal_thermal_nociception0.91052021
74MP0005409_darkened_coat_color0.88507068
75MP0008872_abnormal_physiological_respon0.87451572
76MP0001905_abnormal_dopamine_level0.86329572
77MP0004133_heterotaxia0.85265641
78MP0001440_abnormal_grooming_behavior0.84401737
79MP0009780_abnormal_chondrocyte_physiolo0.83718425
80* MP0002066_abnormal_motor_capabilities/c0.83032450
81MP0003890_abnormal_embryonic-extraembry0.82910787
82* MP0000026_abnormal_inner_ear0.81850830
83MP0001764_abnormal_homeostasis0.81067087
84MP0002102_abnormal_ear_morphology0.80751010
85MP0000955_abnormal_spinal_cord0.80658549
86MP0003879_abnormal_hair_cell0.79678376
87MP0003861_abnormal_nervous_system0.78212810
88MP0005171_absent_coat_pigmentation0.77535012
89MP0008004_abnormal_stomach_pH0.76405259
90MP0005174_abnormal_tail_pigmentation0.75607391
91MP0003698_abnormal_male_reproductive0.75268131
92MP0002210_abnormal_sex_determination0.74964983
93MP0001929_abnormal_gametogenesis0.74784696
94MP0005167_abnormal_blood-brain_barrier0.74650338
95MP0000639_abnormal_adrenal_gland0.74484821
96MP0003941_abnormal_skin_development0.73980198
97MP0003690_abnormal_glial_cell0.73505114
98MP0002909_abnormal_adrenal_gland0.71888168
99MP0000427_abnormal_hair_cycle0.71804360
100MP0003122_maternal_imprinting0.71768078
101MP0003787_abnormal_imprinting0.71075595
102MP0005394_taste/olfaction_phenotype0.70697590
103MP0005499_abnormal_olfactory_system0.70697590
104MP0003633_abnormal_nervous_system0.70079499
105MP0000049_abnormal_middle_ear0.69911926
106MP0002152_abnormal_brain_morphology0.68732264
107MP0004811_abnormal_neuron_physiology0.66902959
108MP0004782_abnormal_surfactant_physiolog0.65427579
109MP0001177_atelectasis0.64729217
110MP0004145_abnormal_muscle_electrophysio0.64430505
111MP0003631_nervous_system_phenotype0.63819637
112MP0004858_abnormal_nervous_system0.60884034
113MP0003632_abnormal_nervous_system0.60205599
114MP0005248_abnormal_Harderian_gland0.60002485
115MP0008260_abnormal_autophagy0.59938610
116MP0000569_abnormal_digit_pigmentation0.57559939
117MP0005197_abnormal_uvea_morphology0.57374147
118MP0002332_abnormal_exercise_endurance0.54539105
119MP0008789_abnormal_olfactory_epithelium0.49028983
120MP0005379_endocrine/exocrine_gland_phen0.48943675
121MP0002069_abnormal_eating/drinking_beha0.48347449
122MP0004085_abnormal_heartbeat0.48318517
123MP0004019_abnormal_vitamin_homeostasis0.46352569
124MP0001299_abnormal_eye_distance/0.43956061
125MP0004215_abnormal_myocardial_fiber0.43462218
126MP0005535_abnormal_body_temperature0.42429357
127MP0002277_abnormal_respiratory_mucosa0.42094254

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)8.80556818
2Dyschromatopsia (HP:0007641)8.72491892
3Abnormal rod and cone electroretinograms (HP:0008323)8.25317665
4Bony spicule pigmentary retinopathy (HP:0007737)8.20955257
5Central scotoma (HP:0000603)7.22351549
6Abnormality of macular pigmentation (HP:0008002)7.18747078
7Pigmentary retinal degeneration (HP:0001146)6.67654841
8Decreased central vision (HP:0007663)6.60704283
9Pendular nystagmus (HP:0012043)6.42722867
10Abolished electroretinogram (ERG) (HP:0000550)6.26594775
11Scotoma (HP:0000575)6.22521346
12Chorioretinal atrophy (HP:0000533)5.97143992
13Attenuation of retinal blood vessels (HP:0007843)5.96676480
14Severe visual impairment (HP:0001141)5.40585744
15Photophobia (HP:0000613)4.68905743
16Macular degeneration (HP:0000608)4.58672156
17Increased corneal curvature (HP:0100692)4.42035287
18Keratoconus (HP:0000563)4.42035287
19Vitreoretinal degeneration (HP:0000655)4.24896872
20Type II diabetes mellitus (HP:0005978)4.17962697
21Choroideremia (HP:0001139)4.13083071
22Constricted visual fields (HP:0001133)3.80207577
23Genetic anticipation (HP:0003743)3.75023028
24Cone-rod dystrophy (HP:0000548)3.62836783
25* Retinitis pigmentosa (HP:0000510)3.45419368
26Posterior subcapsular cataract (HP:0007787)3.12994283
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.07979827
28Hemiparesis (HP:0001269)2.93509813
29Abnormality of the labia minora (HP:0012880)2.93050402
30Epileptic encephalopathy (HP:0200134)2.91489276
31Abnormality of midbrain morphology (HP:0002418)2.86804388
32Molar tooth sign on MRI (HP:0002419)2.86804388
33Febrile seizures (HP:0002373)2.84652111
34Megalencephaly (HP:0001355)2.78845707
35Gait imbalance (HP:0002141)2.69850212
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.67457039
37Progressive visual loss (HP:0000529)2.67234022
38Focal motor seizures (HP:0011153)2.65970803
39Congenital primary aphakia (HP:0007707)2.58651246
40Retinal atrophy (HP:0001105)2.54124072
41Abnormality of the ischium (HP:0003174)2.53479882
42True hermaphroditism (HP:0010459)2.42155293
43Hepatoblastoma (HP:0002884)2.41620434
44Medial flaring of the eyebrow (HP:0010747)2.40525648
45Nephrogenic diabetes insipidus (HP:0009806)2.37091102
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37074133
47Optic disc pallor (HP:0000543)2.35851341
48Hyperventilation (HP:0002883)2.28157376
49Nephronophthisis (HP:0000090)2.24347428
50Supernumerary spleens (HP:0009799)2.22663053
51Hypoplastic labia majora (HP:0000059)2.21060251
52Pancreatic fibrosis (HP:0100732)2.19222584
53Oligodactyly (HP:0012165)2.17808128
54Aqueductal stenosis (HP:0002410)2.16326004
55Hypoplastic ischia (HP:0003175)2.12036257
56Alacrima (HP:0000522)2.09190051
57Oligodactyly (hands) (HP:0001180)2.08391637
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.08391090
59Progressive cerebellar ataxia (HP:0002073)2.06863783
60Intestinal atresia (HP:0011100)2.05933765
61Action tremor (HP:0002345)2.05758393
62Retinal dysplasia (HP:0007973)2.04012287
63* Congenital sensorineural hearing impairment (HP:0008527)2.03016543
64Cupped ear (HP:0000378)2.02948142
65Type II lissencephaly (HP:0007260)2.00766813
66Congenital stationary night blindness (HP:0007642)11.4679432
67Poor coordination (HP:0002370)1.99819673
68Limb dystonia (HP:0002451)1.99263446
69Septo-optic dysplasia (HP:0100842)1.98804886
70Labial hypoplasia (HP:0000066)1.98778206
71Dysdiadochokinesis (HP:0002075)1.98521013
72Anencephaly (HP:0002323)1.97935801
73Abnormality of the labia majora (HP:0012881)1.97490008
74Hemiplegia (HP:0002301)1.97396896
75Absent speech (HP:0001344)1.96399427
76Vaginal atresia (HP:0000148)1.96327535
77Gonadotropin excess (HP:0000837)1.95758914
78Wide nasal bridge (HP:0000431)1.94630802
79Abnormality of the renal medulla (HP:0100957)1.94277348
80Subcapsular cataract (HP:0000523)1.93809170
81Aplasia/Hypoplasia of the fovea (HP:0008060)1.93627445
82Hypoplasia of the fovea (HP:0007750)1.93627445
83Genital tract atresia (HP:0001827)1.93599691
84Epileptiform EEG discharges (HP:0011182)1.92437274
85Broad-based gait (HP:0002136)1.92101797
86Enlarged penis (HP:0000040)1.91133562
87Abnormal sex determination (HP:0012244)1.91082467
88Sex reversal (HP:0012245)1.91082467
89Polyphagia (HP:0002591)1.88903828
90Decreased circulating renin level (HP:0003351)1.86400947
91EEG with generalized epileptiform discharges (HP:0011198)1.85935934
92Polydipsia (HP:0001959)1.85003317
93Abnormal drinking behavior (HP:0030082)1.85003317
94Hypsarrhythmia (HP:0002521)1.84629580
95Facial hemangioma (HP:0000329)1.83314069
96Aplasia/Hypoplasia of the lens (HP:0008063)1.82424828
97Increased circulating renin level (HP:0000848)1.80268555
98Decreased lacrimation (HP:0000633)1.80066145
99Chronic hepatic failure (HP:0100626)1.78600951
100Abnormality of the fovea (HP:0000493)1.76558834
101Midline defect of the nose (HP:0004122)1.75873724
102Short tibia (HP:0005736)1.75820350
103Hypoplastic female external genitalia (HP:0012815)1.75319396
104Narrow forehead (HP:0000341)1.75179016
105Abnormality of the pubic bones (HP:0003172)1.72319685
106Tented upper lip vermilion (HP:0010804)1.71974512
107Male pseudohermaphroditism (HP:0000037)1.71089399
108Congenital hepatic fibrosis (HP:0002612)1.70385618
109Laryngomalacia (HP:0001601)1.69670487
110Pancreatic cysts (HP:0001737)1.68879232
111Postaxial foot polydactyly (HP:0001830)1.68553039
112Abnormality of the renal cortex (HP:0011035)1.68308233
113Abnormality of the corticospinal tract (HP:0002492)1.68254545
114Myokymia (HP:0002411)1.66260774
115Focal seizures (HP:0007359)1.65379157
116Visual hallucinations (HP:0002367)1.64209770
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.60512774
118Optic nerve hypoplasia (HP:0000609)1.55947802
119Gaze-evoked nystagmus (HP:0000640)1.54930399
120Peripheral hypomyelination (HP:0007182)1.49688256
121Severe Myopia (HP:0011003)1.45768685
122Macroorchidism (HP:0000053)1.45193740
123Chorioretinal coloboma (HP:0000567)1.44191149
124Blue irides (HP:0000635)1.44096152
125Astigmatism (HP:0000483)1.43797571
126Specific learning disability (HP:0001328)1.43133816
127Horizontal nystagmus (HP:0000666)1.40137635
128Generalized tonic-clonic seizures (HP:0002069)1.39667375
129Cystic liver disease (HP:0006706)1.39248531
130Absence seizures (HP:0002121)1.37185294
131Drooling (HP:0002307)1.35248951
132Excessive salivation (HP:0003781)1.35248951
133Optic atrophy (HP:0000648)1.33679649
134Poor eye contact (HP:0000817)1.33385432
135Protruding tongue (HP:0010808)1.31685267
136Atonic seizures (HP:0010819)1.29850619
137Inappropriate behavior (HP:0000719)1.29405465
138Synostosis involving the elbow (HP:0003938)1.27556531
139Humeroradial synostosis (HP:0003041)1.27556531
140Widely spaced teeth (HP:0000687)1.27443196
141Abnormality of the nasal septum (HP:0000419)1.25809762
142Sclerocornea (HP:0000647)1.25218163
143Short foot (HP:0001773)1.25049407
144Dialeptic seizures (HP:0011146)1.23336430
145Anxiety (HP:0000739)1.20188422
146Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19860303
147Absent septum pellucidum (HP:0001331)1.19225292
148Depression (HP:0000716)1.19032004
149Truncal ataxia (HP:0002078)1.18963641
150Supranuclear gaze palsy (HP:0000605)1.18304655
151Aplasia/Hypoplasia of the macula (HP:0008059)1.18241425
152Corneal dystrophy (HP:0001131)1.18026070
153Urinary bladder sphincter dysfunction (HP:0002839)1.17752145
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.17637121
155Postaxial hand polydactyly (HP:0001162)1.17592562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.28172461
2GRK14.99379260
3NTRK32.62676295
4MAP2K72.27447452
5PBK2.25755699
6TNIK2.24093036
7MAP3K42.19961806
8INSRR2.11632585
9MARK12.02776912
10ACVR1B1.88622437
11PHKG21.61645067
12PHKG11.61645067
13PINK11.57973869
14PRPF4B1.57275243
15EPHA41.53651923
16NTRK21.47560109
17IRAK21.47313557
18SGK2231.41650707
19SGK4941.41650707
20WEE11.38872773
21PAK31.35255490
22SGK21.29809718
23CAMK1G1.29551678
24PAK61.28178843
25MAPK131.26916565
26BMPR21.26464776
27AKT31.24846241
28ADRBK21.21018001
29PNCK1.20879843
30RIPK41.20479427
31MKNK21.19969542
32SIK21.18771188
33STK381.17876371
34PLK41.17585565
35NUAK11.16935665
36NEK61.14137035
37CDK31.13779127
38MAP3K131.12132699
39MAPK71.06133217
40MUSK1.04482801
41PKN11.04361135
42ADRBK10.98696796
43CAMK2G0.98171302
44GRK50.97666737
45PLK20.97392797
46CAMK2A0.95460458
47HIPK20.90164094
48YES10.90080659
49STK390.89396220
50CDK50.88601881
51TGFBR10.88064423
52MAP3K90.87305523
53CSNK1G20.87080752
54TNK20.83560311
55MAP2K40.82564332
56SGK30.82272888
57ERBB30.81919252
58GRK70.81896004
59CAMK2D0.81742247
60OXSR10.81367948
61DAPK20.80367913
62DYRK20.80335749
63FGFR20.80058632
64MAP3K120.80026686
65CAMK1D0.78074122
66DYRK1A0.78016507
67CSNK1G10.75450406
68NTRK10.74820948
69TIE10.71751198
70MAP4K20.69875287
71WNK10.68969739
72PRKCE0.68526738
73TYRO30.67927825
74FES0.67595836
75PRKCG0.67460968
76MAPK120.65150351
77MAPKAPK50.63693604
78SGK10.63641394
79PTK2B0.63590473
80BRD40.62823085
81MINK10.61301724
82STK38L0.60857427
83ERBB40.59235625
84CAMK10.58914405
85TRIM280.57965840
86BMPR1B0.57637222
87PRKAA20.57428803
88CAMKK10.56290018
89FER0.55755350
90CSNK1D0.55045193
91PRKCZ0.54958691
92MAP3K140.54556339
93PRKCH0.53745106
94PDGFRA0.52765882
95PDGFRB0.52318031
96ROCK10.51904568
97MET0.51202505
98ERBB20.50817966
99PRKCB0.50314576
100FGR0.48316660
101FRK0.47995730
102IRAK10.47267922
103MAPK150.47123137
104PRKG10.46904532
105TAOK30.46733055
106CSNK1G30.46381435
107BCR0.45986097
108RPS6KA30.45903239
109RPS6KB20.44745296
110STK110.44277447
111KSR10.44141210
112UHMK10.44116410
113ICK0.43876401
114CAMK2B0.43787366
115MKNK10.42007237
116WNK40.41770639
117PRKACA0.41281689
118RET0.41182300
119PRKACB0.40541344
120CSNK1A1L0.37645153
121MAPK100.37625976
122SIK30.36244033
123PRKD30.35986957
124WNK30.35169928
125MAP3K10.34725068
126CAMK40.34646903
127TSSK60.33881748
128CSNK1A10.32251067
129ROCK20.30943322
130RPS6KB10.30092177
131STK30.29191289
132DMPK0.28653616
133GSK3B0.28045669
134PRKCA0.27485641

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.71798034
2Nicotine addiction_Homo sapiens_hsa050332.59500016
3Olfactory transduction_Homo sapiens_hsa047402.37081363
4GABAergic synapse_Homo sapiens_hsa047272.27922230
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16452954
6Morphine addiction_Homo sapiens_hsa050322.15570673
7Phototransduction_Homo sapiens_hsa0474411.0632732
8Glutamatergic synapse_Homo sapiens_hsa047241.92490783
9Circadian entrainment_Homo sapiens_hsa047131.83768275
10Serotonergic synapse_Homo sapiens_hsa047261.64871636
11Butanoate metabolism_Homo sapiens_hsa006501.58302264
12Dopaminergic synapse_Homo sapiens_hsa047281.52433659
13Cholinergic synapse_Homo sapiens_hsa047251.51486735
14Insulin secretion_Homo sapiens_hsa049111.49841937
15Salivary secretion_Homo sapiens_hsa049701.20294505
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19439483
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.19392952
18Bile secretion_Homo sapiens_hsa049761.18620102
19Cocaine addiction_Homo sapiens_hsa050301.14975456
20Taste transduction_Homo sapiens_hsa047421.14683366
21Amphetamine addiction_Homo sapiens_hsa050311.13191373
22Circadian rhythm_Homo sapiens_hsa047101.12184835
23Nitrogen metabolism_Homo sapiens_hsa009101.11550309
24Renin secretion_Homo sapiens_hsa049241.09111620
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05335204
26Calcium signaling pathway_Homo sapiens_hsa040201.03773367
27Collecting duct acid secretion_Homo sapiens_hsa049661.01549776
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99762639
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99625613
30Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99166363
31Oxytocin signaling pathway_Homo sapiens_hsa049210.97397280
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95902206
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94555090
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93683124
35Gastric acid secretion_Homo sapiens_hsa049710.90628592
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90057074
37Long-term depression_Homo sapiens_hsa047300.88225261
38cAMP signaling pathway_Homo sapiens_hsa040240.87386248
39Oocyte meiosis_Homo sapiens_hsa041140.84283510
40Tryptophan metabolism_Homo sapiens_hsa003800.83945025
41Long-term potentiation_Homo sapiens_hsa047200.83220253
42Basal transcription factors_Homo sapiens_hsa030220.82873324
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81799758
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80838897
45Hippo signaling pathway_Homo sapiens_hsa043900.78101341
46Glycerolipid metabolism_Homo sapiens_hsa005610.77890962
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75299449
48Histidine metabolism_Homo sapiens_hsa003400.74964367
49Type II diabetes mellitus_Homo sapiens_hsa049300.74216329
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.72456248
51Ether lipid metabolism_Homo sapiens_hsa005650.71428164
52Rheumatoid arthritis_Homo sapiens_hsa053230.71398819
53beta-Alanine metabolism_Homo sapiens_hsa004100.71051117
54Dilated cardiomyopathy_Homo sapiens_hsa054140.70934072
55Axon guidance_Homo sapiens_hsa043600.70422736
56GnRH signaling pathway_Homo sapiens_hsa049120.69374771
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69080082
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68473066
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68116101
60Propanoate metabolism_Homo sapiens_hsa006400.66449920
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65602916
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65366646
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64201169
64Sphingolipid metabolism_Homo sapiens_hsa006000.64125446
65Protein export_Homo sapiens_hsa030600.63603015
66Type I diabetes mellitus_Homo sapiens_hsa049400.62491270
67Caffeine metabolism_Homo sapiens_hsa002320.62403191
68MAPK signaling pathway_Homo sapiens_hsa040100.62124741
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61976219
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61313428
71Cardiac muscle contraction_Homo sapiens_hsa042600.61145024
72Fanconi anemia pathway_Homo sapiens_hsa034600.60742890
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60208874
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.59305987
75Ovarian steroidogenesis_Homo sapiens_hsa049130.59148989
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57735820
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57372967
78Vibrio cholerae infection_Homo sapiens_hsa051100.55797329
79Gap junction_Homo sapiens_hsa045400.55347331
80ErbB signaling pathway_Homo sapiens_hsa040120.55076791
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53674614
82Ras signaling pathway_Homo sapiens_hsa040140.53084028
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52207291
84Basal cell carcinoma_Homo sapiens_hsa052170.49618312
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48527272
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48294281
87Rap1 signaling pathway_Homo sapiens_hsa040150.47760192
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47735619
89Chemokine signaling pathway_Homo sapiens_hsa040620.47332914
90Pancreatic secretion_Homo sapiens_hsa049720.46498180
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46062681
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44888411
93ABC transporters_Homo sapiens_hsa020100.44800452
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43940166
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43405972
96Fatty acid metabolism_Homo sapiens_hsa012120.43301043
97Choline metabolism in cancer_Homo sapiens_hsa052310.43222368
98Glioma_Homo sapiens_hsa052140.42517706
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.41027956
100PPAR signaling pathway_Homo sapiens_hsa033200.40869566
101MicroRNAs in cancer_Homo sapiens_hsa052060.40277724
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.39283797
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38370629
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37785012
105Inositol phosphate metabolism_Homo sapiens_hsa005620.35976931
106Dorso-ventral axis formation_Homo sapiens_hsa043200.35567063
107Melanogenesis_Homo sapiens_hsa049160.34010953
108African trypanosomiasis_Homo sapiens_hsa051430.31807612
109Mineral absorption_Homo sapiens_hsa049780.31805861
110Phagosome_Homo sapiens_hsa041450.31523539
111Graft-versus-host disease_Homo sapiens_hsa053320.30889179
112Estrogen signaling pathway_Homo sapiens_hsa049150.29581894
113Alcoholism_Homo sapiens_hsa050340.29530117
114Wnt signaling pathway_Homo sapiens_hsa043100.29374290
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.28313367
116Thyroid hormone synthesis_Homo sapiens_hsa049180.28166789
117Melanoma_Homo sapiens_hsa052180.28080427
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.26624283
119Other glycan degradation_Homo sapiens_hsa005110.26464499
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25920640
121Retinol metabolism_Homo sapiens_hsa008300.25021997
122Lysosome_Homo sapiens_hsa041420.23287693
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22574671
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21839195
125Renal cell carcinoma_Homo sapiens_hsa052110.21025683
126Autoimmune thyroid disease_Homo sapiens_hsa053200.20679519
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20220330
128Fatty acid elongation_Homo sapiens_hsa000620.19517530
129Linoleic acid metabolism_Homo sapiens_hsa005910.19034081
130Tight junction_Homo sapiens_hsa045300.17347755
131Hedgehog signaling pathway_Homo sapiens_hsa043400.15525586

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