PCDH17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.65372767
2axon ensheathment in central nervous system (GO:0032291)5.25595361
3central nervous system myelination (GO:0022010)5.25595361
4presynaptic membrane assembly (GO:0097105)4.80695123
5transmission of nerve impulse (GO:0019226)4.74116458
6presynaptic membrane organization (GO:0097090)4.34835602
7locomotory exploration behavior (GO:0035641)4.22018423
8neuron recognition (GO:0008038)4.13103382
9vocalization behavior (GO:0071625)3.96163923
10myelination (GO:0042552)3.95484232
11axon ensheathment (GO:0008366)3.90421396
12ensheathment of neurons (GO:0007272)3.90421396
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87112348
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.87072501
15fatty acid elongation (GO:0030497)3.80132816
16gamma-aminobutyric acid signaling pathway (GO:0007214)3.78878168
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.76156724
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76096899
19neuronal ion channel clustering (GO:0045161)3.74963138
20long-chain fatty acid biosynthetic process (GO:0042759)3.74048708
21pyrimidine nucleobase catabolic process (GO:0006208)3.72820063
22negative regulation of neurotransmitter secretion (GO:0046929)3.72652600
23axonal fasciculation (GO:0007413)3.71485264
24righting reflex (GO:0060013)3.66782533
25glutamate receptor signaling pathway (GO:0007215)3.66181769
26protein localization to synapse (GO:0035418)3.64836254
27dendritic spine morphogenesis (GO:0060997)3.60571114
28neuronal action potential propagation (GO:0019227)3.59940112
29negative regulation of neurotransmitter transport (GO:0051589)3.55784210
30L-amino acid import (GO:0043092)3.51236738
31nucleobase catabolic process (GO:0046113)3.48196512
32synaptic vesicle exocytosis (GO:0016079)3.47066432
33exploration behavior (GO:0035640)3.43061107
34behavioral response to nicotine (GO:0035095)3.42297001
35synaptic transmission, glutamatergic (GO:0035249)3.38880931
36nonmotile primary cilium assembly (GO:0035058)3.36221053
37negative regulation of axon extension (GO:0030517)3.34169377
38substantia nigra development (GO:0021762)3.33578162
39serotonin metabolic process (GO:0042428)3.31659283
40negative regulation of cytosolic calcium ion concentration (GO:0051481)3.31457365
41neuron-neuron synaptic transmission (GO:0007270)3.31412684
42mechanosensory behavior (GO:0007638)3.30562910
43positive regulation of synapse assembly (GO:0051965)3.27332214
44negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.25098350
45gamma-aminobutyric acid transport (GO:0015812)3.24799496
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.23133440
47regulation of glutamate receptor signaling pathway (GO:1900449)3.22911904
48regulation of synaptic vesicle exocytosis (GO:2000300)3.16896836
49glycerophospholipid catabolic process (GO:0046475)3.15673080
50postsynaptic membrane organization (GO:0001941)3.15571198
51cerebellar granule cell differentiation (GO:0021707)3.14128734
52layer formation in cerebral cortex (GO:0021819)3.12958620
53cellular response to epinephrine stimulus (GO:0071872)3.07924022
54positive regulation of action potential (GO:0045760)3.06984025
55dendrite morphogenesis (GO:0048813)3.04240347
56glutamate secretion (GO:0014047)3.03073762
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00559860
58regulation of synapse structural plasticity (GO:0051823)3.00286293
59neuronal action potential (GO:0019228)3.00019102
60cerebral cortex radially oriented cell migration (GO:0021799)2.99665030
61membrane depolarization during action potential (GO:0086010)2.98769118
62neurotransmitter-gated ion channel clustering (GO:0072578)2.98697270
63negative regulation of axonogenesis (GO:0050771)2.97904549
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96890818
65cellular potassium ion homeostasis (GO:0030007)2.96687557
66synapse assembly (GO:0007416)2.95318664
67neuron remodeling (GO:0016322)2.94730256
68positive regulation of membrane potential (GO:0045838)2.94368150
69synaptic vesicle maturation (GO:0016188)2.93867414
70C4-dicarboxylate transport (GO:0015740)2.92689081
71dendrite development (GO:0016358)2.92447754
72membrane assembly (GO:0071709)2.92133198
73primary amino compound metabolic process (GO:1901160)2.91054228
74adult walking behavior (GO:0007628)2.90773638
75response to epinephrine (GO:0071871)2.89917389
76synapse organization (GO:0050808)2.87702947
77oligodendrocyte differentiation (GO:0048709)2.87619576
78regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87321301
79mating behavior (GO:0007617)2.86566287
80neurotransmitter catabolic process (GO:0042135)2.85823538
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83951277
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82664872
83regulation of respiratory system process (GO:0044065)2.81713840
84regulation of collateral sprouting (GO:0048670)2.81199464
85cerebellar Purkinje cell layer development (GO:0021680)2.80929072
86response to auditory stimulus (GO:0010996)2.80844182
87reflex (GO:0060004)2.79770788
88amino acid import (GO:0043090)2.78399496
89regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76843663
90response to histamine (GO:0034776)2.76766701
91regulation of dendritic spine morphogenesis (GO:0061001)2.76026297
92regulation of dendrite morphogenesis (GO:0048814)2.75490332
93positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.75425014
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74966346
95regulation of neuronal synaptic plasticity (GO:0048168)2.73591814
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71998576
97membrane hyperpolarization (GO:0060081)2.71934025
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70384838
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.70283254
100long-term memory (GO:0007616)2.70166689
101adaptation of signaling pathway (GO:0023058)2.69848981
102long-term synaptic potentiation (GO:0060291)2.69447535
103myelination in peripheral nervous system (GO:0022011)2.68993379
104peripheral nervous system axon ensheathment (GO:0032292)2.68993379
105dopamine biosynthetic process (GO:0042416)2.68790446
106startle response (GO:0001964)2.68263401
107neurotransmitter secretion (GO:0007269)2.68257181
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65495062
109regulation of postsynaptic membrane potential (GO:0060078)2.64921748
110regulation of synaptic vesicle transport (GO:1902803)2.62218683
111adult behavior (GO:0030534)2.61441041
112limb bud formation (GO:0060174)2.61229179
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.60638171
114cellular response to monoamine stimulus (GO:0071868)2.60008009
115cellular response to catecholamine stimulus (GO:0071870)2.60008009
116protein polyglutamylation (GO:0018095)2.59832452
117neurotransmitter transport (GO:0006836)2.59512802
118regulation of glutamate secretion (GO:0014048)2.59323284
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58251486
120positive regulation of dendritic spine development (GO:0060999)2.56945056
121regulation of synapse assembly (GO:0051963)2.56219872
122regulation of dendritic spine development (GO:0060998)2.55668514
123action potential (GO:0001508)2.54490019
124regulation of neurotransmitter uptake (GO:0051580)2.54403072
125auditory behavior (GO:0031223)2.54260504
126membrane depolarization (GO:0051899)2.53700651
127adult locomotory behavior (GO:0008344)2.51985101
128potassium ion homeostasis (GO:0055075)2.51178727
129potassium ion import (GO:0010107)2.50890086
130negative regulation of dendrite development (GO:2000171)2.50177324
131inner ear receptor stereocilium organization (GO:0060122)2.50002119
132detection of calcium ion (GO:0005513)2.49974577
133response to amphetamine (GO:0001975)2.49848932
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.49381826
135cochlea development (GO:0090102)2.46798049
136insulin secretion (GO:0030073)2.44214672
137central nervous system projection neuron axonogenesis (GO:0021952)2.44154763
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43148372
139regulation of respiratory gaseous exchange (GO:0043576)2.42167758
140regulation of calcium ion-dependent exocytosis (GO:0017158)2.41210671
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.40240451
142retina layer formation (GO:0010842)2.38887236
143synaptic vesicle docking involved in exocytosis (GO:0016081)2.38501254
144limb development (GO:0060173)2.38061781
145appendage development (GO:0048736)2.38061781
146short-term memory (GO:0007614)2.36889209
147kidney morphogenesis (GO:0060993)2.36415370
148response to dietary excess (GO:0002021)2.33523800
149positive regulation of meiosis (GO:0045836)2.33231939
150atrial cardiac muscle cell action potential (GO:0086014)2.32789834
151behavioral response to ethanol (GO:0048149)2.32082290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50177742
2GBX2_23144817_ChIP-Seq_PC3_Human3.78790523
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92916591
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90046478
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89950917
6TAF15_26573619_Chip-Seq_HEK293_Human2.72852624
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.55465560
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46697186
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46697186
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46094676
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.42765635
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41479622
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39691686
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33904868
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28811648
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19151923
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16694568
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12975182
19AR_21572438_ChIP-Seq_LNCaP_Human2.12767545
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12134920
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07412065
22* REST_21632747_ChIP-Seq_MESCs_Mouse2.07165709
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04399794
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03620335
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99970850
26DROSHA_22980978_ChIP-Seq_HELA_Human1.98659714
27* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96571723
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.96089144
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86045229
30* CBX2_27304074_Chip-Seq_ESCs_Mouse1.82735746
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75281796
32P300_19829295_ChIP-Seq_ESCs_Human1.74999878
33* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73775765
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68753999
35* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66862574
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65397088
37FUS_26573619_Chip-Seq_HEK293_Human1.63577172
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.62876167
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62656551
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61470725
41* SMAD3_21741376_ChIP-Seq_EPCs_Human1.61240862
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60445399
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60026235
44VDR_22108803_ChIP-Seq_LS180_Human1.58958456
45SMAD4_21799915_ChIP-Seq_A2780_Human1.58846561
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55892145
47* REST_18959480_ChIP-ChIP_MESCs_Mouse1.53431324
48* RARB_27405468_Chip-Seq_BRAIN_Mouse1.49902065
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49874980
50ER_23166858_ChIP-Seq_MCF-7_Human1.49110239
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48787584
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48402125
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44686096
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44213785
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43643177
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42328065
57* RNF2_27304074_Chip-Seq_NSC_Mouse1.36557569
58ZNF274_21170338_ChIP-Seq_K562_Hela1.34222298
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28599730
60STAT3_23295773_ChIP-Seq_U87_Human1.23946781
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.23141962
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22558435
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21436793
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21167317
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19758780
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19508435
67* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18707587
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18586465
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.18513408
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.17761919
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16260213
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15802990
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.15315564
74* AR_25329375_ChIP-Seq_VCAP_Human1.14623725
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14033259
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.12588663
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.12316388
78TCF4_23295773_ChIP-Seq_U87_Human1.12154006
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09981013
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09981013
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09848949
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09542858
83TCF4_22108803_ChIP-Seq_LS180_Human1.09446651
84TP53_18474530_ChIP-ChIP_U2OS_Human1.09235273
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.08299100
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08072947
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08034671
88CBP_20019798_ChIP-Seq_JUKART_Human1.08034671
89P53_22387025_ChIP-Seq_ESCs_Mouse1.07594475
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06723887
91AHR_22903824_ChIP-Seq_MCF-7_Human1.05580244
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.05376536
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05243821
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04119437
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02888915
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02874936
97* FLI1_21867929_ChIP-Seq_TH2_Mouse1.02087886
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01572169
99KDM2B_26808549_Chip-Seq_REH_Human1.01181128
100IGF1R_20145208_ChIP-Seq_DFB_Human1.00584698
101* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99977272
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98601278
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98341600
104SMAD4_21741376_ChIP-Seq_EPCs_Human0.98044268
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97614172
106* JUN_21703547_ChIP-Seq_K562_Human0.97353708
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96963177
108* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96911405
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.96129839
110* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95458576
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95023931
112EWS_26573619_Chip-Seq_HEK293_Human0.94837837
113CMYC_18555785_Chip-Seq_ESCs_Mouse0.94111884
114* AR_19668381_ChIP-Seq_PC3_Human0.93575217
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.90565579
116TP53_16413492_ChIP-PET_HCT116_Human0.89977136
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.87253916
118BCAT_22108803_ChIP-Seq_LS180_Human0.86583609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.28412112
2MP0004859_abnormal_synaptic_plasticity4.08571807
3MP0004270_analgesia3.26405549
4MP0003635_abnormal_synaptic_transmissio3.22544245
5MP0009745_abnormal_behavioral_response2.96969770
6MP0002064_seizures2.93932067
7MP0005423_abnormal_somatic_nervous2.82118937
8MP0001486_abnormal_startle_reflex2.78326544
9MP0009046_muscle_twitch2.78179198
10MP0002272_abnormal_nervous_system2.65127188
11MP0001529_abnormal_vocalization2.51818017
12MP0002063_abnormal_learning/memory/cond2.50972105
13MP0001440_abnormal_grooming_behavior2.42234540
14MP0000778_abnormal_nervous_system2.41234605
15MP0002572_abnormal_emotion/affect_behav2.40924892
16MP0000920_abnormal_myelination2.40024394
17MP0001968_abnormal_touch/_nociception2.29184039
18MP0002734_abnormal_mechanical_nocicepti2.27461079
19MP0004885_abnormal_endolymph2.18760213
20MP0006276_abnormal_autonomic_nervous2.15877738
21MP0000569_abnormal_digit_pigmentation2.08014037
22MP0003690_abnormal_glial_cell2.07697540
23MP0001905_abnormal_dopamine_level2.05904858
24MP0004742_abnormal_vestibular_system2.05108579
25MP0003329_amyloid_beta_deposits1.96276627
26MP0002067_abnormal_sensory_capabilities1.92214317
27MP0004142_abnormal_muscle_tone1.90113770
28MP0002736_abnormal_nociception_after1.88583094
29MP0003283_abnormal_digestive_organ1.87971878
30MP0001501_abnormal_sleep_pattern1.87807546
31MP0001984_abnormal_olfaction1.87285961
32MP0005171_absent_coat_pigmentation1.82761325
33MP0002735_abnormal_chemical_nociception1.82654044
34MP0005409_darkened_coat_color1.79920884
35MP0002733_abnormal_thermal_nociception1.72952828
36MP0001485_abnormal_pinna_reflex1.69251089
37MP0005386_behavior/neurological_phenoty1.67387594
38MP0004924_abnormal_behavior1.67387594
39MP0001970_abnormal_pain_threshold1.63400410
40MP0002184_abnormal_innervation1.60910659
41MP0002909_abnormal_adrenal_gland1.58178688
42MP0008877_abnormal_DNA_methylation1.56770581
43MP0004133_heterotaxia1.56391520
44MP0002882_abnormal_neuron_morphology1.55554240
45MP0005645_abnormal_hypothalamus_physiol1.52660387
46MP0002557_abnormal_social/conspecific_i1.52363013
47MP0003634_abnormal_glial_cell1.51938567
48MP0002638_abnormal_pupillary_reflex1.48396331
49MP0003121_genomic_imprinting1.46411524
50MP0005551_abnormal_eye_electrophysiolog1.45595301
51MP0003136_yellow_coat_color1.44752970
52MP0000955_abnormal_spinal_cord1.44521300
53MP0002066_abnormal_motor_capabilities/c1.41273964
54MP0003122_maternal_imprinting1.40895670
55MP0008569_lethality_at_weaning1.37482365
56MP0002822_catalepsy1.37248252
57MP0003195_calcinosis1.33889449
58MP0001188_hyperpigmentation1.33314426
59MP0010386_abnormal_urinary_bladder1.32446307
60MP0005187_abnormal_penis_morphology1.31431671
61MP0002229_neurodegeneration1.30613252
62MP0001502_abnormal_circadian_rhythm1.27086641
63MP0002163_abnormal_gland_morphology1.25543434
64MP0005623_abnormal_meninges_morphology1.21241264
65MP0005646_abnormal_pituitary_gland1.20617071
66MP0006292_abnormal_olfactory_placode1.20332969
67MP0001963_abnormal_hearing_physiology1.19778669
68MP0002876_abnormal_thyroid_physiology1.18785257
69MP0000462_abnormal_digestive_system1.18538556
70MP0002752_abnormal_somatic_nervous1.17964366
71MP0003632_abnormal_nervous_system1.15506491
72MP0001944_abnormal_pancreas_morphology1.11237956
73MP0002152_abnormal_brain_morphology1.10478519
74MP0000566_synostosis1.07674080
75MP0002938_white_spotting1.07243391
76MP0004811_abnormal_neuron_physiology1.06774912
77MP0009780_abnormal_chondrocyte_physiolo1.06092300
78MP0006072_abnormal_retinal_apoptosis1.05507791
79MP0003123_paternal_imprinting1.02901016
80MP0003631_nervous_system_phenotype1.00994116
81MP0004145_abnormal_muscle_electrophysio1.00230806
82MP0000026_abnormal_inner_ear0.95701989
83MP0004858_abnormal_nervous_system0.95536541
84MP0003633_abnormal_nervous_system0.95252456
85MP0001177_atelectasis0.94438448
86MP0001299_abnormal_eye_distance/0.94346816
87MP0003119_abnormal_digestive_system0.93207429
88MP0000631_abnormal_neuroendocrine_gland0.93075795
89MP0003890_abnormal_embryonic-extraembry0.91092000
90MP0004043_abnormal_pH_regulation0.89282131
91MP0000751_myopathy0.88892333
92MP0005394_taste/olfaction_phenotype0.88297122
93MP0005499_abnormal_olfactory_system0.88297122
94MP0002090_abnormal_vision0.86577563
95MP0005253_abnormal_eye_physiology0.83205926
96MP0003938_abnormal_ear_development0.82956383
97MP0005174_abnormal_tail_pigmentation0.81078596
98MP0000604_amyloidosis0.80784617
99MP0003787_abnormal_imprinting0.80351106
100MP0003011_delayed_dark_adaptation0.80078529
101MP0004215_abnormal_myocardial_fiber0.77840546
102MP0004085_abnormal_heartbeat0.75883346
103MP0005195_abnormal_posterior_eye0.75534058
104MP0004134_abnormal_chest_morphology0.75345570
105MP0004272_abnormal_basement_membrane0.74848616
106MP0002069_abnormal_eating/drinking_beha0.73966656
107MP0002102_abnormal_ear_morphology0.72008980
108MP0002693_abnormal_pancreas_physiology0.71359934
109MP0000013_abnormal_adipose_tissue0.71209651
110MP0001986_abnormal_taste_sensitivity0.67821346
111MP0003937_abnormal_limbs/digits/tail_de0.67446188
112MP0002751_abnormal_autonomic_nervous0.67311128
113MP0005410_abnormal_fertilization0.67305634
114MP0003137_abnormal_impulse_conducting0.66610340
115MP0005220_abnormal_exocrine_pancreas0.65753120
116MP0003861_abnormal_nervous_system0.65490275
117MP0002837_dystrophic_cardiac_calcinosis0.65289506
118MP0001943_abnormal_respiration0.63506533
119MP0008874_decreased_physiological_sensi0.61446530
120MP0003385_abnormal_body_wall0.59963897
121MP0003879_abnormal_hair_cell0.58080549
122MP0009250_abnormal_appendicular_skeleto0.58033017
123MP0001664_abnormal_digestion0.57785600
124MP0008789_abnormal_olfactory_epithelium0.57473494
125MP0005379_endocrine/exocrine_gland_phen0.56080209
126MP0001661_extended_life_span0.55988122
127MP0008872_abnormal_physiological_respon0.54810471
128MP0005535_abnormal_body_temperature0.51977818
129MP0010770_preweaning_lethality0.51029142

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.95714580
2Atonic seizures (HP:0010819)4.78705438
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.75584989
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.75584989
5Neurofibrillary tangles (HP:0002185)4.14510332
6Abnormality of the corticospinal tract (HP:0002492)4.06625112
7Focal seizures (HP:0007359)4.06514747
8Myokymia (HP:0002411)3.91742806
9Sensory axonal neuropathy (HP:0003390)3.89338932
10Akinesia (HP:0002304)3.31724555
11Cerebral inclusion bodies (HP:0100314)3.26943308
12Epileptic encephalopathy (HP:0200134)3.23906984
13Absence seizures (HP:0002121)3.11718068
14Dialeptic seizures (HP:0011146)3.08643912
15Spastic gait (HP:0002064)3.07643871
16Pancreatic fibrosis (HP:0100732)3.07111967
17Supranuclear gaze palsy (HP:0000605)3.05404451
18Congenital sensorineural hearing impairment (HP:0008527)3.04967804
19Peripheral hypomyelination (HP:0007182)3.03599214
20Febrile seizures (HP:0002373)3.00096283
21Nephronophthisis (HP:0000090)2.97931282
22Progressive cerebellar ataxia (HP:0002073)2.96752293
23True hermaphroditism (HP:0010459)2.86359526
24Agitation (HP:0000713)2.86295674
25Hyperventilation (HP:0002883)2.83779571
26Abnormality of midbrain morphology (HP:0002418)2.83614099
27Molar tooth sign on MRI (HP:0002419)2.83614099
28Intestinal atresia (HP:0011100)2.80915360
29Generalized tonic-clonic seizures (HP:0002069)2.80655999
30Dysmetria (HP:0001310)2.80184288
31Broad-based gait (HP:0002136)2.79540767
32Fetal akinesia sequence (HP:0001989)2.78674076
33Pancreatic cysts (HP:0001737)2.78016322
34Parakeratosis (HP:0001036)2.76291431
35Epileptiform EEG discharges (HP:0011182)2.69859114
36Intention tremor (HP:0002080)2.65447646
37Limb dystonia (HP:0002451)2.64969061
38EEG with generalized epileptiform discharges (HP:0011198)2.63716895
39Hypothermia (HP:0002045)2.62800136
40Polyphagia (HP:0002591)2.61385189
41Retinal dysplasia (HP:0007973)2.59048825
42Insidious onset (HP:0003587)2.50232284
43Termporal pattern (HP:0011008)2.50232284
44Hypsarrhythmia (HP:0002521)2.48778909
45Visual hallucinations (HP:0002367)2.48126005
46Aplasia of the phalanges of the hand (HP:0009802)2.46438635
47Aplasia involving bones of the extremities (HP:0009825)2.46438635
48Aplasia involving bones of the upper limbs (HP:0009823)2.46438635
49Abnormality of the renal medulla (HP:0100957)2.44638741
50Progressive inability to walk (HP:0002505)2.43778350
51Action tremor (HP:0002345)2.41450190
52Abnormal eating behavior (HP:0100738)2.39922038
53Dysdiadochokinesis (HP:0002075)2.39822284
54Pheochromocytoma (HP:0002666)2.39650957
55Scanning speech (HP:0002168)2.34868155
56Increased circulating renin level (HP:0000848)2.29646829
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27251100
58Alacrima (HP:0000522)2.25344739
59Urinary bladder sphincter dysfunction (HP:0002839)2.24264713
60Acute necrotizing encephalopathy (HP:0006965)2.22391274
61Vaginal atresia (HP:0000148)2.19990445
62Hemiparesis (HP:0001269)2.19208276
63Lower limb muscle weakness (HP:0007340)2.17453390
64Large for gestational age (HP:0001520)2.17406130
65Generalized myoclonic seizures (HP:0002123)2.16855682
66Nephrogenic diabetes insipidus (HP:0009806)2.16264836
67Gait imbalance (HP:0002141)2.16226582
68Genital tract atresia (HP:0001827)2.16171402
69Leukodystrophy (HP:0002415)2.15952254
70Gaze-evoked nystagmus (HP:0000640)2.15069712
71Neuroendocrine neoplasm (HP:0100634)2.14160023
72Abnormal drinking behavior (HP:0030082)2.14009824
73Polydipsia (HP:0001959)2.14009824
74Ankle clonus (HP:0011448)2.13704236
75Congenital malformation of the right heart (HP:0011723)2.13044035
76Double outlet right ventricle (HP:0001719)2.13044035
77Blue irides (HP:0000635)2.12741114
78Cerebral hemorrhage (HP:0001342)2.12692733
79Drooling (HP:0002307)2.12501475
80Excessive salivation (HP:0003781)2.12501475
81Thickened helices (HP:0000391)2.12358663
82Synostosis involving the elbow (HP:0003938)2.11203892
83Humeroradial synostosis (HP:0003041)2.11203892
84Absent speech (HP:0001344)2.11034220
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.10558400
86Absent/shortened dynein arms (HP:0200106)2.10558400
87Anxiety (HP:0000739)2.09741045
88Hyperinsulinemic hypoglycemia (HP:0000825)2.09208606
89Abnormality of the labia minora (HP:0012880)2.08649285
90Abnormality of the parathyroid morphology (HP:0011766)2.07858851
91Optic nerve hypoplasia (HP:0000609)2.05502915
92Progressive macrocephaly (HP:0004481)2.04558058
93Esotropia (HP:0000565)2.03037625
94Type II lissencephaly (HP:0007260)2.01892024
95Hepatoblastoma (HP:0002884)1.99181985
96Congenital stationary night blindness (HP:0007642)1.98482047
97Abnormal ciliary motility (HP:0012262)1.95532615
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.95256197
99Status epilepticus (HP:0002133)1.95254396
100Impaired vibration sensation in the lower limbs (HP:0002166)1.94759150
101Onion bulb formation (HP:0003383)1.91861956
102Postural tremor (HP:0002174)1.91540577
103Gastrointestinal atresia (HP:0002589)1.91177868
104Genetic anticipation (HP:0003743)1.91023334
105Abnormality of the renal cortex (HP:0011035)1.89641181
106Truncal ataxia (HP:0002078)1.89199859
107Cystic liver disease (HP:0006706)1.88833165
108Protruding tongue (HP:0010808)1.88537947
109Cupped ear (HP:0000378)1.88369706
110Chronic hepatic failure (HP:0100626)1.86982121
111Amblyopia (HP:0000646)1.86539661
112Clumsiness (HP:0002312)1.86285547
113Widely spaced teeth (HP:0000687)1.85936494
114Abnormality of incisor morphology (HP:0011063)1.85885429
115Abnormal hair whorl (HP:0010721)1.84473923
116Oligodactyly (hands) (HP:0001180)1.84028167
117Decreased lacrimation (HP:0000633)1.82272809
118Hypoplastic nipples (HP:0002557)1.82152996
119Renal Fanconi syndrome (HP:0001994)1.81825143
120Abnormal mitochondria in muscle tissue (HP:0008316)1.81802014
121Diminished movement (HP:0002374)1.81621336
122Medial flaring of the eyebrow (HP:0010747)1.81025161
123Anteriorly placed anus (HP:0001545)1.80761705
124Mitochondrial inheritance (HP:0001427)1.80454170
125Abnormality of binocular vision (HP:0011514)1.80072919
126Diplopia (HP:0000651)1.80072919
127Hypoplastic pelvis (HP:0008839)1.79723286
128Urinary urgency (HP:0000012)1.78899890
129Megalencephaly (HP:0001355)1.77501334
130Bowel incontinence (HP:0002607)1.77394945
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77129283
132Specific learning disability (HP:0001328)1.75802790
133Enlarged penis (HP:0000040)1.75270139
134Congenital primary aphakia (HP:0007707)1.74868598
135Muscular hypotonia of the trunk (HP:0008936)1.73884045
136Pachygyria (HP:0001302)1.73477502
137Postaxial hand polydactyly (HP:0001162)1.73359392
138Sclerocornea (HP:0000647)1.73214525
139Hypogonadotrophic hypogonadism (HP:0000044)1.72927881
140Mutism (HP:0002300)1.72699560
141Split foot (HP:0001839)1.72658358
142Hemiplegia (HP:0002301)1.72557914
143Labial hypoplasia (HP:0000066)1.72485293
144Partial agenesis of the corpus callosum (HP:0001338)1.72454620
145Morphological abnormality of the pyramidal tract (HP:0002062)1.71992548
146Lissencephaly (HP:0001339)1.71803497
147Short tibia (HP:0005736)1.70646400
148Hypoglycemic seizures (HP:0002173)1.70017853
149Inability to walk (HP:0002540)1.69692133
150Occipital encephalocele (HP:0002085)1.69385612
151Poor coordination (HP:0002370)1.69106709
152Methylmalonic acidemia (HP:0002912)1.66862838
153Volvulus (HP:0002580)1.65838308
154Tubular atrophy (HP:0000092)1.64372213
155Sleep apnea (HP:0010535)1.62677629
156Male pseudohermaphroditism (HP:0000037)1.62479969
157Hyperglycemia (HP:0003074)1.62333657
158Poor suck (HP:0002033)1.61994581
159Torticollis (HP:0000473)1.61807708
160Hypoglycemic coma (HP:0001325)1.61629002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.85628262
2STK393.99076610
3FRK3.36299033
4CASK3.02687065
5OXSR12.96903684
6NTRK32.91658593
7MARK12.91202923
8EPHA42.88455230
9PNCK2.40041325
10MAPK132.20664739
11BCR2.05236314
12NTRK21.99463553
13MAP3K41.92747414
14MAP4K21.81801873
15MAP3K91.80431051
16NTRK11.76075640
17UHMK11.74316688
18PKN11.73812012
19MINK11.69345242
20WNK41.65368267
21MAP2K71.62758566
22PINK11.62333968
23GRK11.61131861
24PAK61.60812092
25PRPF4B1.46645783
26FES1.44161410
27NEK61.40698138
28CSNK1G31.39646379
29CSNK1G21.37529225
30FGFR21.34065981
31INSRR1.32540010
32EPHB11.32284737
33CDK191.30796161
34TYRO31.30001462
35CSNK1A1L1.23590393
36PAK31.23305783
37ICK1.23116057
38CDK51.19617037
39PHKG21.18690783
40PHKG11.18690783
41FGR1.17452532
42MAP3K121.17386872
43CAMK2B1.12464073
44CAMK2A1.11774079
45ROCK21.10390263
46MKNK21.08090920
47MAP2K41.06001731
48ACVR1B1.05730579
49IRAK21.03078979
50CSNK1G10.98351652
51WNK10.97978751
52PLK20.92408029
53SGK20.90675563
54CAMK2D0.89820872
55CDK140.87722785
56NME10.84770408
57ARAF0.84008453
58PRKCG0.83489535
59GRK50.79339369
60MAPK150.78920452
61GRK70.77382099
62PRKCE0.77033798
63KSR10.76956926
64RIPK40.75368454
65SGK4940.75352169
66SGK2230.75352169
67CDK150.75206615
68CDK180.75055128
69MARK20.73971432
70NUAK10.73336886
71DYRK20.70224865
72STK110.69834039
73KSR20.69468283
74MAP3K130.69381366
75MAPKAPK50.68993753
76BMPR1B0.66704425
77IRAK10.65214271
78CDK11A0.64801319
79BMPR20.63373604
80PRKCQ0.61109931
81DYRK1A0.60319271
82CAMK10.60150314
83ROCK10.59682407
84AKT30.59538004
85MST40.59034336
86PTK2B0.58864554
87ADRBK20.58629934
88FYN0.57034326
89STK160.56343178
90CAMK2G0.55942426
91WNK30.55827902
92ERBB30.55824422
93CSNK1D0.54229561
94SIK20.53628567
95DMPK0.50853050
96EPHA30.50835636
97LIMK10.49695795
98TAOK30.49462665
99SGK30.47208118
100PRKG10.46858346
101MAP3K20.46778635
102MET0.46185702
103CAMK1G0.45198386
104CSNK1A10.44653988
105PRKD30.44573774
106ADRBK10.44447998
107PRKACA0.43474199
108PBK0.42019472
109TRIM280.41857256
110TLK10.41617648
111TIE10.41581449
112CSNK1E0.41352839
113MUSK0.41338323
114DAPK20.41142500
115PDPK10.41120044
116MAP3K60.40452022
117ERBB40.40346758
118CAMKK10.40182070
119STK38L0.39941526
120PRKCH0.39572785
121PRKACB0.39156362
122SGK10.38293556
123CAMKK20.37560090
124PRKCA0.37478505
125PRKCZ0.36979556
126CLK10.36941036
127RPS6KA30.36673418
128NLK0.36054427
129FER0.35859508
130PRKAA10.34854570
131MAP2K60.34167078
132CAMK40.30490223
133TAOK10.28119428

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67136915
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.68030864
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.65114434
4GABAergic synapse_Homo sapiens_hsa047272.60745626
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57438944
6Oxidative phosphorylation_Homo sapiens_hsa001902.48109174
7Glutamatergic synapse_Homo sapiens_hsa047242.43047933
8Synaptic vesicle cycle_Homo sapiens_hsa047212.38514242
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30887089
10Morphine addiction_Homo sapiens_hsa050322.26412222
11Axon guidance_Homo sapiens_hsa043602.17597978
12Serotonergic synapse_Homo sapiens_hsa047262.09754969
13Collecting duct acid secretion_Homo sapiens_hsa049662.06094190
14Circadian entrainment_Homo sapiens_hsa047132.00292080
15Steroid biosynthesis_Homo sapiens_hsa001001.87756404
16Long-term potentiation_Homo sapiens_hsa047201.82266504
17Alzheimers disease_Homo sapiens_hsa050101.81635745
18Parkinsons disease_Homo sapiens_hsa050121.75706131
19Dopaminergic synapse_Homo sapiens_hsa047281.74368405
20Amphetamine addiction_Homo sapiens_hsa050311.70957371
21Salivary secretion_Homo sapiens_hsa049701.70495435
22Taste transduction_Homo sapiens_hsa047421.70443892
23Olfactory transduction_Homo sapiens_hsa047401.69261003
24Long-term depression_Homo sapiens_hsa047301.67628458
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.63959401
26Cholinergic synapse_Homo sapiens_hsa047251.57133505
27Cardiac muscle contraction_Homo sapiens_hsa042601.52409600
28Fatty acid elongation_Homo sapiens_hsa000621.51396641
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50743534
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46898118
31Cocaine addiction_Homo sapiens_hsa050301.45374037
32Renin secretion_Homo sapiens_hsa049241.44971111
33Nitrogen metabolism_Homo sapiens_hsa009101.40819497
34Ether lipid metabolism_Homo sapiens_hsa005651.39188902
35Gastric acid secretion_Homo sapiens_hsa049711.38664293
36Vibrio cholerae infection_Homo sapiens_hsa051101.38076515
37Calcium signaling pathway_Homo sapiens_hsa040201.25145364
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23630718
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20888111
40Oxytocin signaling pathway_Homo sapiens_hsa049211.20401942
41Huntingtons disease_Homo sapiens_hsa050161.17320366
42Insulin secretion_Homo sapiens_hsa049111.16262398
43Gap junction_Homo sapiens_hsa045401.13112881
44Phototransduction_Homo sapiens_hsa047441.12096918
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10721152
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09333300
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09025625
48Circadian rhythm_Homo sapiens_hsa047101.08158423
49Butanoate metabolism_Homo sapiens_hsa006501.07516208
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07076624
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05172630
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96990465
53GnRH signaling pathway_Homo sapiens_hsa049120.96371787
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96284218
55Linoleic acid metabolism_Homo sapiens_hsa005910.93995614
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.92162973
57Dorso-ventral axis formation_Homo sapiens_hsa043200.92081034
58cAMP signaling pathway_Homo sapiens_hsa040240.91935743
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91397600
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89878430
61Tryptophan metabolism_Homo sapiens_hsa003800.88852609
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86289100
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86107006
64Sulfur metabolism_Homo sapiens_hsa009200.84993852
65ErbB signaling pathway_Homo sapiens_hsa040120.84624750
66Rheumatoid arthritis_Homo sapiens_hsa053230.82421611
67Renal cell carcinoma_Homo sapiens_hsa052110.81301760
68Ras signaling pathway_Homo sapiens_hsa040140.81011663
69Pancreatic secretion_Homo sapiens_hsa049720.80070721
70Vitamin B6 metabolism_Homo sapiens_hsa007500.79751415
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76156248
72Folate biosynthesis_Homo sapiens_hsa007900.75684197
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75334853
74Sphingolipid metabolism_Homo sapiens_hsa006000.74572151
75Melanogenesis_Homo sapiens_hsa049160.73562104
76Estrogen signaling pathway_Homo sapiens_hsa049150.73244609
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70484459
78Choline metabolism in cancer_Homo sapiens_hsa052310.69712512
79beta-Alanine metabolism_Homo sapiens_hsa004100.69439909
80Regulation of autophagy_Homo sapiens_hsa041400.66377996
81ABC transporters_Homo sapiens_hsa020100.65934610
82Selenocompound metabolism_Homo sapiens_hsa004500.64414536
83Mineral absorption_Homo sapiens_hsa049780.63286152
84Ovarian steroidogenesis_Homo sapiens_hsa049130.63046612
85Bile secretion_Homo sapiens_hsa049760.61955362
86Fatty acid biosynthesis_Homo sapiens_hsa000610.61164174
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60870899
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60372520
89MAPK signaling pathway_Homo sapiens_hsa040100.59471370
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.57709113
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57613325
92Basal cell carcinoma_Homo sapiens_hsa052170.57421244
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56913969
94Dilated cardiomyopathy_Homo sapiens_hsa054140.56118446
95Propanoate metabolism_Homo sapiens_hsa006400.54833253
96Tight junction_Homo sapiens_hsa045300.53481316
97Thyroid hormone synthesis_Homo sapiens_hsa049180.51392412
98Hippo signaling pathway_Homo sapiens_hsa043900.50685891
99Histidine metabolism_Homo sapiens_hsa003400.50224975
100Type II diabetes mellitus_Homo sapiens_hsa049300.49642167
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49467985
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48767967
103Glioma_Homo sapiens_hsa052140.47960237
104Peroxisome_Homo sapiens_hsa041460.47444804
105Glucagon signaling pathway_Homo sapiens_hsa049220.46599180
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45963097
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45843522
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44491439
109Alcoholism_Homo sapiens_hsa050340.44199605
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43906246
111Wnt signaling pathway_Homo sapiens_hsa043100.41459323
112Endocytosis_Homo sapiens_hsa041440.39504146
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38652449
114Rap1 signaling pathway_Homo sapiens_hsa040150.38209285
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38086968
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37692962
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37463638
118Hedgehog signaling pathway_Homo sapiens_hsa043400.37103939
119Phagosome_Homo sapiens_hsa041450.36820224
120Prion diseases_Homo sapiens_hsa050200.36430900
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32415423
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.30865583
123Oocyte meiosis_Homo sapiens_hsa041140.30036835
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29634525
125African trypanosomiasis_Homo sapiens_hsa051430.29481357
126Protein export_Homo sapiens_hsa030600.27845451
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27748187
128ECM-receptor interaction_Homo sapiens_hsa045120.26355733
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26075151

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