PCDH18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vascular endothelial growth factor signaling pathway (GO:1900746)7.73584586
2glomerular filtration (GO:0003094)7.47520078
3regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)7.35046094
4glomerular epithelial cell development (GO:0072310)7.09176449
5positive regulation of tolerance induction (GO:0002645)6.95174902
6establishment of apical/basal cell polarity (GO:0035089)6.93774393
7glomerular basement membrane development (GO:0032836)6.92547560
8axon extension involved in axon guidance (GO:0048846)6.89368781
9neuron projection extension involved in neuron projection guidance (GO:1902284)6.89368781
10renal filtration (GO:0097205)6.65941663
11chondrocyte development (GO:0002063)6.33427466
12establishment of monopolar cell polarity (GO:0061162)6.20081000
13establishment or maintenance of monopolar cell polarity (GO:0061339)6.20081000
14negative regulation of T cell differentiation in thymus (GO:0033085)6.11863484
15retinal ganglion cell axon guidance (GO:0031290)6.01938237
16regulation of tolerance induction (GO:0002643)5.90809118
17negative regulation of B cell mediated immunity (GO:0002713)5.72955626
18negative regulation of immunoglobulin mediated immune response (GO:0002890)5.72955626
19lung epithelium development (GO:0060428)5.60039581
20axonal fasciculation (GO:0007413)5.44783259
21negative regulation of humoral immune response (GO:0002921)5.42492145
22extracellular fibril organization (GO:0043206)5.35291146
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.07476558
24neuronal action potential propagation (GO:0019227)5.03701214
25insulin-like growth factor receptor signaling pathway (GO:0048009)5.03076437
26negative regulation of axon guidance (GO:1902668)5.02294259
27tolerance induction (GO:0002507)4.96983633
28regulation of chemokine-mediated signaling pathway (GO:0070099)4.77477557
29protein heterotrimerization (GO:0070208)4.74936212
30chondrocyte proliferation (GO:0035988)4.70508584
31establishment of tissue polarity (GO:0007164)4.54556719
32establishment of planar polarity (GO:0001736)4.54556719
33cell proliferation involved in metanephros development (GO:0072203)4.52279293
34negative chemotaxis (GO:0050919)4.51880328
35negative regulation of leukocyte chemotaxis (GO:0002689)4.49436210
36mesenchymal-epithelial cell signaling (GO:0060638)4.49022575
37fibril organization (GO:0097435)4.43636246
38left/right pattern formation (GO:0060972)4.43026558
39negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.36103626
40negative regulation of embryonic development (GO:0045992)4.35801546
41kidney mesenchyme development (GO:0072074)4.31002520
42histamine secretion (GO:0001821)4.30762307
43metanephric mesenchyme development (GO:0072075)4.27830569
44dendritic spine morphogenesis (GO:0060997)4.10875996
45sequestering of extracellular ligand from receptor (GO:0035581)3.98026873
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.89333281
47dermatan sulfate biosynthetic process (GO:0030208)3.83157719
48lung lobe morphogenesis (GO:0060463)3.82309521
49mesenchyme morphogenesis (GO:0072132)3.79631842
50regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.69736737
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.67433999
52anterior/posterior axis specification, embryo (GO:0008595)3.67093821
53neuronal ion channel clustering (GO:0045161)3.66376036
54negative regulation of vascular permeability (GO:0043116)3.64322323
55negative regulation of axon extension involved in axon guidance (GO:0048843)3.63845503
56regulation of axon guidance (GO:1902667)3.62511587
57regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.61640145
58extracellular matrix assembly (GO:0085029)3.56905703
59dermatan sulfate metabolic process (GO:0030205)3.50872945
60paraxial mesoderm development (GO:0048339)3.49512023
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49286505
62face development (GO:0060324)3.48949216
63endodermal cell differentiation (GO:0035987)3.48017960
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46790842
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46790842
66cranial nerve morphogenesis (GO:0021602)3.44137918
67convergent extension (GO:0060026)3.43739628
68endocardial cushion morphogenesis (GO:0003203)3.43685760
69collagen fibril organization (GO:0030199)3.43475715
70regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.40499270
71negative regulation of chondrocyte differentiation (GO:0032331)3.38976876
72smooth muscle tissue development (GO:0048745)3.37987737
73camera-type eye morphogenesis (GO:0048593)3.37935568
74cell proliferation involved in kidney development (GO:0072111)3.37382152
75positive regulation of catenin import into nucleus (GO:0035413)3.33865794
76outer ear morphogenesis (GO:0042473)3.33249893
77positive regulation of BMP signaling pathway (GO:0030513)3.31547259
78atrial cardiac muscle cell action potential (GO:0086014)3.30634320
79neuron recognition (GO:0008038)3.30099630
80regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.30075676
81regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.27530467
82urogenital system development (GO:0001655)3.24896055
83hippo signaling (GO:0035329)3.24265902
84bone trabecula formation (GO:0060346)3.23409606
85histamine transport (GO:0051608)3.23354769
86collagen metabolic process (GO:0032963)3.23101934
87mesenchymal cell proliferation (GO:0010463)3.23037621
88regulation of germinal center formation (GO:0002634)3.22585366
89cell migration involved in sprouting angiogenesis (GO:0002042)3.21717840
90epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.20219004
91stress granule assembly (GO:0034063)3.19073645
92endothelial cell morphogenesis (GO:0001886)3.18474319
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.18353076
94negative regulation of osteoblast proliferation (GO:0033689)3.17485221
95cochlea morphogenesis (GO:0090103)3.15954674
96non-canonical Wnt signaling pathway (GO:0035567)3.14029512
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13762357
98endocardial cushion development (GO:0003197)3.11925273
99cell migration involved in heart development (GO:0060973)3.11307579
100DNA synthesis involved in DNA repair (GO:0000731)3.11076923
101lung-associated mesenchyme development (GO:0060484)3.10353852
102collagen catabolic process (GO:0030574)3.07849600
103regulation of axon extension involved in axon guidance (GO:0048841)3.07530765
104notochord development (GO:0030903)3.07497356
105negative regulation of smooth muscle cell migration (GO:0014912)3.07224240
106neural crest cell development (GO:0014032)3.06035805
107motor neuron axon guidance (GO:0008045)3.04577741
108multicellular organismal macromolecule metabolic process (GO:0044259)3.04340413
109establishment or maintenance of apical/basal cell polarity (GO:0035088)3.02553209
110establishment or maintenance of bipolar cell polarity (GO:0061245)3.02553209
111regulation of establishment of planar polarity (GO:0090175)3.01968257
112negative regulation of cell aging (GO:0090344)3.00540260
113regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00139516
114skin morphogenesis (GO:0043589)2.96899768
115muscle cell migration (GO:0014812)2.95653505
116positive regulation of SMAD protein import into nucleus (GO:0060391)2.95352699
117regulation of organ formation (GO:0003156)2.94191714
118negative regulation of fibroblast apoptotic process (GO:2000270)2.92703403
119heparan sulfate proteoglycan metabolic process (GO:0030201)2.92047039
120cell proliferation in forebrain (GO:0021846)2.92044019
121cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91011241
122positive regulation of mesenchymal cell proliferation (GO:0002053)2.90049858
123innervation (GO:0060384)2.89226848
124multicellular organismal metabolic process (GO:0044236)2.88433011
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.88269022
126body morphogenesis (GO:0010171)2.86963904
127vasculature development (GO:0001944)2.86886837
128embryonic cranial skeleton morphogenesis (GO:0048701)2.84327241
129multicellular organismal catabolic process (GO:0044243)2.83337776
130regulation of gastrulation (GO:0010470)2.83199408
131mesenchymal cell development (GO:0014031)2.82239015
132regulation of non-canonical Wnt signaling pathway (GO:2000050)2.81920772
133cellular response to ATP (GO:0071318)2.81493496
134midgut development (GO:0007494)2.81034725
135neuron fate determination (GO:0048664)2.79503381
136lymphangiogenesis (GO:0001946)2.79454812
137blood vessel maturation (GO:0001955)2.78824500
138positive regulation of smoothened signaling pathway (GO:0045880)2.78777422
139artery morphogenesis (GO:0048844)2.78325605
140epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77591670
141peptidyl-histidine modification (GO:0018202)2.76875211
142regulation of mononuclear cell migration (GO:0071675)2.76575682
143positive regulation of fatty acid beta-oxidation (GO:0032000)2.76231402
144positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.75755253
145positive regulation of cardiac muscle cell proliferation (GO:0060045)2.75637137
146negative regulation of axon extension (GO:0030517)2.75635517
147glomerular visceral epithelial cell development (GO:0072015)2.74762337
148regulation of cell fate specification (GO:0042659)2.74705772
149artery development (GO:0060840)2.73721847
150regulation of catenin import into nucleus (GO:0035412)2.73529249
151substrate adhesion-dependent cell spreading (GO:0034446)2.73310372
152lateral sprouting from an epithelium (GO:0060601)2.73122022
153pericardium development (GO:0060039)2.73109280
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72967532
155craniofacial suture morphogenesis (GO:0097094)2.72680867
156aorta morphogenesis (GO:0035909)2.72495053
157negative regulation of cartilage development (GO:0061037)2.72379330
158keratan sulfate catabolic process (GO:0042340)2.70867448
159basement membrane organization (GO:0071711)2.70467001
160positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.68336733
161positive regulation of cardiac muscle tissue development (GO:0055025)2.65939241
162regulation of mesenchymal cell proliferation (GO:0010464)2.64661549
163organ induction (GO:0001759)2.63683267
164cell surface receptor signaling pathway involved in heart development (GO:0061311)2.62945377
165Notch signaling involved in heart development (GO:0061314)2.62876473
166cardiac left ventricle morphogenesis (GO:0003214)2.61854551
167heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.61709576
168negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.60725489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62769138
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.87003388
3* EED_16625203_ChIP-ChIP_MESCs_Mouse3.54412293
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.12930242
5* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.83378409
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.83080162
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.77793862
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.76050166
9* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.72606630
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68820683
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68820683
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59628365
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56725320
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51900188
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43209493
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.32847669
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.31489783
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.26952312
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24723707
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23416673
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22546153
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20182181
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19636440
24POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14246625
25* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12296138
26TP53_20018659_ChIP-ChIP_R1E_Mouse2.08556930
27* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04578301
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99514186
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.99253139
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92536234
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85140158
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.82042565
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.81670720
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81594499
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.77835885
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77345672
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.75183485
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74001195
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64984862
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64674790
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64674790
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63503160
43GBX2_23144817_ChIP-Seq_PC3_Human1.62925256
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62593231
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62498264
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61523520
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.59479717
48TP53_16413492_ChIP-PET_HCT116_Human1.59287407
49* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56967947
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.55772224
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53724869
52* EWS_26573619_Chip-Seq_HEK293_Human1.51687812
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48440781
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48139674
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47767801
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.45698656
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.43843788
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42333079
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.42317108
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42288651
61* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.42184221
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41812759
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39584374
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.38930493
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38178291
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32095143
67* P300_19829295_ChIP-Seq_ESCs_Human1.31708872
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29254714
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28820562
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28593740
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28579306
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28217257
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26469592
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26469592
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26469592
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.25986528
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24975304
78SMAD4_21799915_ChIP-Seq_A2780_Human1.24499142
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24057366
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24055091
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23621815
82* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22630678
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22579658
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22465426
85DROSHA_22980978_ChIP-Seq_HELA_Human1.22135991
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21252152
87CLOCK_20551151_ChIP-Seq_293T_Human1.19845771
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.19190026
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19064558
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18754020
91EZH2_22144423_ChIP-Seq_EOC_Human1.18663243
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.18437089
93* SOX9_26525672_Chip-Seq_HEART_Mouse1.16651786
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16516906
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16209158
96* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15044623
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.14793973
98* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14122003
99* CJUN_26792858_Chip-Seq_BT549_Human1.14007985
100BRD4_25478319_ChIP-Seq_HGPS_Human1.13810036
101* SA1_22415368_ChIP-Seq_MEFs_Mouse1.12294468
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11516419
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11280272
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10781521
105* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10481679
106* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09902202
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09141991
108FUS_26573619_Chip-Seq_HEK293_Human1.08760064
109SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08705508
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08244865
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07935472
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07195308
113AHR_22903824_ChIP-Seq_MCF-7_Human1.06594998
114* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05463942
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04534468
116* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04368868
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.04167593
118TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03938339
119TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03682065
120* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03271531
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02947609
122ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02199258
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01718116
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.99346037
125AR_21909140_ChIP-Seq_LNCAP_Human0.98757448
126* TAF15_26573619_Chip-Seq_HEK293_Human0.98546144
127TP53_18474530_ChIP-ChIP_U2OS_Human0.97577878
128* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96400372
129AR_19668381_ChIP-Seq_PC3_Human0.96153305
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91827702
131PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91260159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.94256586
2MP0003942_abnormal_urinary_system3.57371013
3MP0009384_cardiac_valve_regurgitation3.51171019
4MP0003122_maternal_imprinting3.17986700
5MP0001958_emphysema2.90584772
6MP0010030_abnormal_orbit_morphology2.85676021
7MP0005257_abnormal_intraocular_pressure2.83023443
8MP0000534_abnormal_ureter_morphology2.79993616
9MP0002249_abnormal_larynx_morphology2.75120229
10MP0005076_abnormal_cell_differentiation2.56783695
11MP0008438_abnormal_cutaneous_collagen2.56019819
12MP0009053_abnormal_anal_canal2.51072353
13MP0003385_abnormal_body_wall2.44834976
14MP0002396_abnormal_hematopoietic_system2.31986973
15MP0005503_abnormal_tendon_morphology2.31777358
16MP0003941_abnormal_skin_development2.31469114
17MP0000467_abnormal_esophagus_morphology2.25569698
18MP0004133_heterotaxia2.19891803
19MP0001299_abnormal_eye_distance/2.19624414
20MP0004272_abnormal_basement_membrane2.17857679
21MP0004084_abnormal_cardiac_muscle2.15052508
22MP0008057_abnormal_DNA_replication2.13715617
23MP0003828_pulmonary_edema2.10166414
24MP0000049_abnormal_middle_ear2.04305288
25MP0002282_abnormal_trachea_morphology2.00281587
26MP0000428_abnormal_craniofacial_morphol1.95697639
27MP0009250_abnormal_appendicular_skeleto1.89178973
28MP0001293_anophthalmia1.88385254
29MP0003315_abnormal_perineum_morphology1.86665480
30MP0003123_paternal_imprinting1.81480451
31MP0010368_abnormal_lymphatic_system1.78601131
32MP0005171_absent_coat_pigmentation1.78055155
33MP0004233_abnormal_muscle_weight1.76858442
34MP0003121_genomic_imprinting1.74970791
35MP0003937_abnormal_limbs/digits/tail_de1.73949999
36MP0002932_abnormal_joint_morphology1.69666538
37MP0006054_spinal_hemorrhage1.69493615
38MP0001542_abnormal_bone_strength1.67808066
39MP0005508_abnormal_skeleton_morphology1.67026690
40MP0003755_abnormal_palate_morphology1.66920864
41MP0002938_white_spotting1.66269437
42MP0003115_abnormal_respiratory_system1.64984188
43MP0005623_abnormal_meninges_morphology1.56001641
44MP0005248_abnormal_Harderian_gland1.47954798
45MP0002092_abnormal_eye_morphology1.44439093
46MP0003283_abnormal_digestive_organ1.44026394
47MP0002295_abnormal_pulmonary_circulatio1.40851377
48MP0000733_abnormal_muscle_development1.38146993
49MP0004197_abnormal_fetal_growth/weight/1.38100692
50MP0003935_abnormal_craniofacial_develop1.37592342
51MP0000462_abnormal_digestive_system1.37578826
52MP0002837_dystrophic_cardiac_calcinosis1.36886193
53MP0002111_abnormal_tail_morphology1.35818896
54MP0000749_muscle_degeneration1.35705303
55MP0000566_synostosis1.35275614
56MP0002233_abnormal_nose_morphology1.32738054
57MP0005595_abnormal_vascular_smooth1.32152920
58MP0002116_abnormal_craniofacial_bone1.31714684
59MP0003137_abnormal_impulse_conducting1.31320909
60MP0003566_abnormal_cell_adhesion1.29676486
61MP0005275_abnormal_skin_tensile1.29098226
62MP0003705_abnormal_hypodermis_morpholog1.28593254
63MP0000163_abnormal_cartilage_morphology1.26031731
64MP0002109_abnormal_limb_morphology1.25620785
65MP0005197_abnormal_uvea_morphology1.24303474
66MP0005023_abnormal_wound_healing1.24052141
67MP0009703_decreased_birth_body1.19825413
68MP0004858_abnormal_nervous_system1.18969096
69MP0000778_abnormal_nervous_system1.16624483
70MP0006138_congestive_heart_failure1.16343026
71MP0002896_abnormal_bone_mineralization1.13377445
72MP0003119_abnormal_digestive_system1.13180523
73MP0002751_abnormal_autonomic_nervous1.11763177
74MP0000750_abnormal_muscle_regeneration1.07294045
75MP0003279_aneurysm1.07239786
76MP0002168_other_aberrant_phenotype1.03831438
77MP0000432_abnormal_head_morphology1.02017513
78MP0002108_abnormal_muscle_morphology1.01829700
79MP0002060_abnormal_skin_morphology1.00750008
80MP0002115_abnormal_skeleton_extremities0.99750027
81MP0002102_abnormal_ear_morphology0.99541962
82MP0000538_abnormal_urinary_bladder0.98779836
83MP0002269_muscular_atrophy0.97817036
84MP0002084_abnormal_developmental_patter0.97738413
85MP0002085_abnormal_embryonic_tissue0.97006078
86MP0005670_abnormal_white_adipose0.96413535
87MP0000762_abnormal_tongue_morphology0.96204155
88MP0003136_yellow_coat_color0.96008577
89MP0003938_abnormal_ear_development0.95952384
90MP0002254_reproductive_system_inflammat0.95726709
91MP0001243_abnormal_dermal_layer0.94969135
92MP0008058_abnormal_DNA_repair0.93835637
93MP0003861_abnormal_nervous_system0.92779892
94MP0001879_abnormal_lymphatic_vessel0.92041588
95MP0000631_abnormal_neuroendocrine_gland0.91594209
96MP0005367_renal/urinary_system_phenotyp0.91444361
97MP0000516_abnormal_urinary_system0.91444361
98MP0005220_abnormal_exocrine_pancreas0.90309991
99MP0009379_abnormal_foot_pigmentation0.89970988
100MP0002177_abnormal_outer_ear0.89364499
101MP0003567_abnormal_fetal_cardiomyocyte0.87594413
102MP0000013_abnormal_adipose_tissue0.86570740
103MP0000350_abnormal_cell_proliferation0.84884642
104MP0005187_abnormal_penis_morphology0.83519839
105MP0005381_digestive/alimentary_phenotyp0.83510351
106MP0002114_abnormal_axial_skeleton0.83222476
107MP0002113_abnormal_skeleton_development0.80806563
108MP0002081_perinatal_lethality0.80264492
109MP0003091_abnormal_cell_migration0.80197292
110MP0002697_abnormal_eye_size0.79718026
111MP0001177_atelectasis0.78639449
112MP0000751_myopathy0.78438314
113MP0005391_vision/eye_phenotype0.78151075
114MP0001849_ear_inflammation0.77910047
115MP0010386_abnormal_urinary_bladder0.77618931
116MP0002184_abnormal_innervation0.77446016
117MP0002234_abnormal_pharynx_morphology0.77392586
118MP0005390_skeleton_phenotype0.77019137
119MP0001286_abnormal_eye_development0.75531187
120MP0004145_abnormal_muscle_electrophysio0.74859023
121MP0010352_gastrointestinal_tract_polyps0.73466656
122MP0004036_abnormal_muscle_relaxation0.73230650
123MP0004742_abnormal_vestibular_system0.73181570
124MP0003950_abnormal_plasma_membrane0.73115961
125MP0004808_abnormal_hematopoietic_stem0.73032186
126MP0000266_abnormal_heart_morphology0.72499279
127MP0002128_abnormal_blood_circulation0.71521972
128MP0000767_abnormal_smooth_muscle0.71130616
129MP0000579_abnormal_nail_morphology0.70306017
130MP0001270_distended_abdomen0.70006324
131MP0001544_abnormal_cardiovascular_syste0.69952423
132MP0005193_abnormal_anterior_eye0.69044939
133MP0006072_abnormal_retinal_apoptosis0.68347117
134MP0001614_abnormal_blood_vessel0.67832212
135MP0002925_abnormal_cardiovascular_devel0.67609060
136MP0002133_abnormal_respiratory_system0.65322086
137MP0005388_respiratory_system_phenotype0.65322086
138MP0004134_abnormal_chest_morphology0.64903818
139MP0008932_abnormal_embryonic_tissue0.64254665
140MP0001175_abnormal_lung_morphology0.61997739

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.60155640
2Short 4th metacarpal (HP:0010044)5.60155640
3Abnormality of the 4th metacarpal (HP:0010012)4.38331132
4Soft skin (HP:0000977)4.32243720
5Shallow orbits (HP:0000586)4.11314234
6Small epiphyses (HP:0010585)3.90814342
7Bladder diverticulum (HP:0000015)3.85692553
8Neonatal short-limb short stature (HP:0008921)3.78858922
9Abnormality of the labia minora (HP:0012880)3.75407461
10Mesangial abnormality (HP:0001966)3.71769537
11Diaphragmatic weakness (HP:0009113)3.68777766
12Abnormality of dentin (HP:0010299)3.50727935
13Chronic hepatic failure (HP:0100626)3.49700035
14Spinal muscular atrophy (HP:0007269)3.49194643
15Protrusio acetabuli (HP:0003179)3.47237299
16Degeneration of anterior horn cells (HP:0002398)3.45498980
17Abnormality of the anterior horn cell (HP:0006802)3.45498980
18Follicular hyperkeratosis (HP:0007502)3.42431890
19Type 1 muscle fiber predominance (HP:0003803)3.38791401
20Aortic aneurysm (HP:0004942)3.31077805
21Ankle contracture (HP:0006466)3.30114151
22Stridor (HP:0010307)3.27834852
23Abnormal tarsal ossification (HP:0008369)3.18325271
24Atrophic scars (HP:0001075)3.14917011
25Ankyloglossia (HP:0010296)3.12852787
26Abnormal pancreas size (HP:0012094)3.11974713
27Genu recurvatum (HP:0002816)2.94450456
28Bowel diverticulosis (HP:0005222)2.89872335
29Carpal bone hypoplasia (HP:0001498)2.87403473
30Wrist flexion contracture (HP:0001239)2.86817794
31Epiphyseal dysplasia (HP:0002656)2.84782646
32Mitral valve prolapse (HP:0001634)2.81093251
33Broad metatarsal (HP:0001783)2.80214071
34Syringomyelia (HP:0003396)2.77504085
35Spinal cord lesions (HP:0100561)2.77504085
36Abnormality of the pancreatic islet cells (HP:0006476)2.75762747
37Abnormality of endocrine pancreas physiology (HP:0012093)2.75762747
38Dilatation of the ascending aorta (HP:0005111)2.75347533
39Cervical subluxation (HP:0003308)2.69178501
40Synostosis of carpal bones (HP:0005048)2.67881465
41Spinal rigidity (HP:0003306)2.67340796
42Premature rupture of membranes (HP:0001788)2.66129787
43Maternal diabetes (HP:0009800)2.65632192
44Septo-optic dysplasia (HP:0100842)2.64994137
45Short metatarsal (HP:0010743)2.62801916
46Fragile skin (HP:0001030)2.61133263
47Partial duplication of the phalanx of hand (HP:0009999)2.60177178
48Slender build (HP:0001533)2.58950634
49Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.58860153
50Overgrowth (HP:0001548)2.47195331
51Hepatoblastoma (HP:0002884)2.45901863
52Ulnar deviation of finger (HP:0009465)2.45503499
53Short hallux (HP:0010109)2.45096726
54Abnormality of oral frenula (HP:0000190)2.44559494
55Mild short stature (HP:0003502)2.44418838
56Flattened epiphyses (HP:0003071)2.41616720
57Abnormal foot bone ossification (HP:0010675)2.39805750
58Peritonitis (HP:0002586)2.38615566
59Aortic dissection (HP:0002647)2.36530185
60Lymphangioma (HP:0100764)2.35634157
61Wide anterior fontanel (HP:0000260)2.33758434
62Blue sclerae (HP:0000592)2.33344097
63Hypoventilation (HP:0002791)2.33264217
64Cutaneous finger syndactyly (HP:0010554)2.30277330
65Cerebral aneurysm (HP:0004944)2.29789536
66Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.28807159
67Deviation of the hallux (HP:0010051)2.27333120
68Hyperextensible skin (HP:0000974)2.25745390
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.25040699
70Hypoplasia of the iris (HP:0007676)2.24714253
71Morphological abnormality of the middle ear (HP:0008609)2.23922971
72Turricephaly (HP:0000262)2.22685815
73Aortic regurgitation (HP:0001659)2.21630522
74Increased corneal curvature (HP:0100692)2.20048271
75Keratoconus (HP:0000563)2.20048271
76Growth hormone deficiency (HP:0000824)2.19663297
77Camptodactyly of toe (HP:0001836)2.19417686
78Midline defect of the nose (HP:0004122)2.17968534
79Ectopia lentis (HP:0001083)2.16910217
80Broad thumb (HP:0011304)2.16287228
81Carpal synostosis (HP:0009702)2.13900667
82Tarsal synostosis (HP:0008368)2.07760929
83Coronal craniosynostosis (HP:0004440)2.07300382
84Preaxial foot polydactyly (HP:0001841)2.06491384
85Short middle phalanx of finger (HP:0005819)2.05282164
86Arterial tortuosity (HP:0005116)2.05086358
87Wide cranial sutures (HP:0010537)2.04921239
88Flat cornea (HP:0007720)2.03958118
89Broad ribs (HP:0000885)2.03622085
90Abnormality of the 2nd finger (HP:0004100)2.01408773
91Periauricular skin pits (HP:0100277)2.01249363
92Preauricular pit (HP:0004467)2.01249363
93Fair hair (HP:0002286)2.00036512
94Spondylolisthesis (HP:0003302)1.99866543
95Ulnar bowing (HP:0003031)1.99473165
96Vascular tortuosity (HP:0004948)1.98682590
97Renal duplication (HP:0000075)1.98553466
98Abnormal number of incisors (HP:0011064)1.97920223
99Aortic valve stenosis (HP:0001650)1.97653601
100Broad toe (HP:0001837)1.96027994
101Abnormal delivery (HP:0001787)1.95774754
102Partial duplication of thumb phalanx (HP:0009944)1.95687940
103Hypoplasia of the maxilla (HP:0000327)1.94672224
104Mitral regurgitation (HP:0001653)1.94646952
105Atrophy/Degeneration involving motor neurons (HP:0007373)1.94243797
106Hallux valgus (HP:0001822)1.93325610
107Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92951318
108Increased number of teeth (HP:0011069)1.92603528
109Enlarged penis (HP:0000040)1.92435788
110Bifid scrotum (HP:0000048)1.92370508
111Cutaneous syndactyly (HP:0012725)1.91019363
112Synostosis involving bones of the feet (HP:0009140)1.90601359
113Synostosis involving bones of the lower limbs (HP:0009138)1.90601359
114Hypoplasia of the odontoid process (HP:0003311)1.89776127
115Mesomelia (HP:0003027)1.89512151
116Abnormality of the parietal bone (HP:0002696)1.89061533
117Calcaneovalgus deformity (HP:0001848)1.86980788
118Limited hip movement (HP:0008800)1.86452254
119Pulmonary artery stenosis (HP:0004415)1.85755377
120Hip contracture (HP:0003273)1.84803240
121Deformed tarsal bones (HP:0008119)1.84381943
122Biliary tract neoplasm (HP:0100574)1.84144368
123Broad long bones (HP:0005622)1.82255902
124Infantile muscular hypotonia (HP:0008947)1.82061450
125Broad phalanges of the hand (HP:0009768)1.81954217
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81526586
127Breech presentation (HP:0001623)1.81333360
128Vertebral arch anomaly (HP:0008438)1.81290701
129Abnormality of the anterior chamber (HP:0000593)1.80434380
130Cheekbone underdevelopment (HP:0010669)1.80379328
131Abnormality of the acetabulum (HP:0003170)1.79964817
132Broad finger (HP:0001500)1.79845287
133Aneurysm (HP:0002617)1.79387696
134Short clavicles (HP:0000894)1.79312577
135Narrow nasal bridge (HP:0000446)1.78735327
136Increased variability in muscle fiber diameter (HP:0003557)1.77446478
137Limb-girdle muscle weakness (HP:0003325)1.76994354
138Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76770366
139Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76585760
140Synostosis involving bones of the hand (HP:0004278)1.75323226
141Broad phalanx (HP:0006009)1.75291270
142Round ear (HP:0100830)1.73883654
143Neoplasm of the heart (HP:0100544)1.73563926
144Abnormality of the odontoid process (HP:0003310)1.73270930
145Disproportionate tall stature (HP:0001519)1.72487617
146Narrow palate (HP:0000189)1.72463111
147Inguinal hernia (HP:0000023)1.72396586
148Joint laxity (HP:0001388)1.70828127
149Abnormality of the middle phalanges of the toes (HP:0010183)1.70766552
150Absent frontal sinuses (HP:0002688)1.70711559
151Long toe (HP:0010511)1.70687036
152Broad hallux (HP:0010055)1.70392862
153Delayed cranial suture closure (HP:0000270)1.70267869
154Biconcave vertebral bodies (HP:0004586)1.69637292
155Vitreoretinal degeneration (HP:0000655)1.68677028
156Hypoplastic labia majora (HP:0000059)1.68584813
157Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.68374731
158Facial hemangioma (HP:0000329)1.68183874
159Protruding ear (HP:0000411)1.68160536
160Wormian bones (HP:0002645)1.67740608
161Hypospadias (HP:0000047)1.67739843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK38.25514817
2NTRK16.09398428
3KSR15.95531064
4EIF2AK35.00634845
5EPHB24.95476342
6BCR4.38498809
7MYLK4.02800176
8NTRK23.32759039
9SIK13.16596410
10AKT33.10521018
11NEK92.18424867
12ERBB21.99971415
13PIK3CG1.84492651
14MINK11.54563032
15EPHB11.54451828
16RIPK11.36428127
17TAF11.36039680
18GRK71.34871489
19MAP3K101.34659510
20TGFBR21.31717548
21MET1.28011325
22STK38L1.27164287
23PNCK1.24954385
24PDGFRA1.20470630
25PBK1.17922297
26DDR21.14829641
27LIMK11.14549177
28EPHA31.04918049
29MELK1.03866299
30ICK0.99800524
31TTN0.98847597
32DYRK1B0.93236744
33LATS10.90806730
34KIT0.90267313
35GRK10.88080750
36MTOR0.85158710
37MATK0.84474438
38CHUK0.83689198
39WNK30.82191060
40MKNK10.81319517
41LATS20.79327096
42CDC42BPA0.79255410
43EPHA40.78731969
44BRD40.75982885
45NLK0.74524870
46ADRBK20.74351277
47STK40.72461246
48CDC70.71837679
49FGFR20.69976545
50PRKD20.69420359
51CDK180.67773684
52PAK60.67761850
53MAPK70.67479851
54EIF2AK20.66615732
55TYRO30.66439610
56TIE10.65031882
57DYRK30.63608021
58MARK10.63540385
59PAK40.62675099
60DYRK20.62381005
61CSF1R0.62005728
62NEK20.61595102
63CDK80.60844862
64MOS0.59403209
65FLT30.58247397
66CASK0.57483293
67STK30.54964887
68GSK3A0.54895968
69DMPK0.51563858
70TRIB30.50750803
71DYRK1A0.49330828
72SRC0.46367438
73WEE10.45836680
74TNIK0.44573673
75ROCK10.44508168
76ADRBK10.44102834
77DAPK30.43717170
78CDK190.43085614
79PLK20.42851194
80PAK20.42536491
81PTK20.42050775
82STK380.42048275
83UHMK10.41156328
84PKN10.41120629
85IRAK20.40682694
86GRK50.40620523
87BRSK20.39958990
88PRKG20.39952477
89MAPK150.39235892
90EGFR0.39080287
91ERBB30.37952139
92MAP3K40.37699759
93PLK10.37340058
94BCKDK0.36910077
95PLK30.36478279
96AURKB0.34662653
97FGFR10.34646378
98CSNK1G10.34249567
99ROCK20.34177321
100SGK20.34095996
101FGFR40.32649827
102CHEK20.32507128
103PAK30.32327163
104CDK60.32224351
105PRKG10.30976224
106PRKCG0.30927868
107NEK10.30616021
108WNK10.30373904
109CAMK1D0.29572774
110CAMK1G0.29348290
111CSNK1A1L0.27857050
112MAPKAPK20.27678987
113CDK10.25736443
114PIK3CA0.25373918
115ABL20.24597984
116CDK140.24376481
117BRSK10.23405904
118ATR0.20325951
119SGK30.19292789
120PRKCE0.19088888
121MAPK80.19063690
122CSNK1A10.18901626
123CDK150.18884729
124SGK4940.17937443
125SGK2230.17937443
126TTK0.17438007
127MAPK90.17108281
128BMX0.16926542
129AKT10.16455865
130MKNK20.16314886
131FER0.16156660
132INSR0.15966531
133FYN0.15785870
134PTK60.15471396
135NTRK30.15231709
136PTK2B0.14771166
137LRRK20.14618530
138PRKCZ0.14276206
139CDK20.13151964
140CSNK1G30.12713314
141PDGFRB0.12551608
142MAPK10.11827563
143CDK11A0.11477891
144CSNK1E0.11045162
145MAPK100.10672981
146SRPK10.09739939
147IGF1R0.09360205
148TGFBR10.09252836
149ERBB40.08865274
150GSK3B0.08776078

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.61648606
2Chronic myeloid leukemia_Homo sapiens_hsa052202.68216618
3Hippo signaling pathway_Homo sapiens_hsa043902.67271894
4Axon guidance_Homo sapiens_hsa043602.65449642
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.64785348
6Hedgehog signaling pathway_Homo sapiens_hsa043402.61148719
7MicroRNAs in cancer_Homo sapiens_hsa052062.38117448
8Glioma_Homo sapiens_hsa052142.33707649
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.32447788
10Bladder cancer_Homo sapiens_hsa052192.25513020
11Adherens junction_Homo sapiens_hsa045202.03955124
12Focal adhesion_Homo sapiens_hsa045102.00243176
13ErbB signaling pathway_Homo sapiens_hsa040121.97073499
14Proteoglycans in cancer_Homo sapiens_hsa052051.89831327
15ECM-receptor interaction_Homo sapiens_hsa045121.84244359
16Notch signaling pathway_Homo sapiens_hsa043301.81613092
17Melanogenesis_Homo sapiens_hsa049161.69097983
18TGF-beta signaling pathway_Homo sapiens_hsa043501.66022252
19Cell cycle_Homo sapiens_hsa041101.65684045
20Wnt signaling pathway_Homo sapiens_hsa043101.63901053
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63824704
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60025286
23Renal cell carcinoma_Homo sapiens_hsa052111.59566145
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.55423202
25Non-small cell lung cancer_Homo sapiens_hsa052231.48828611
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48656006
27Prostate cancer_Homo sapiens_hsa052151.47916802
28Pancreatic cancer_Homo sapiens_hsa052121.45564176
29Endometrial cancer_Homo sapiens_hsa052131.42902174
30Melanoma_Homo sapiens_hsa052181.40999299
31Colorectal cancer_Homo sapiens_hsa052101.39858411
32Dorso-ventral axis formation_Homo sapiens_hsa043201.35110913
33Estrogen signaling pathway_Homo sapiens_hsa049151.34507575
34DNA replication_Homo sapiens_hsa030301.30324199
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28627381
36Dilated cardiomyopathy_Homo sapiens_hsa054141.28316810
37N-Glycan biosynthesis_Homo sapiens_hsa005101.26260140
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24469420
39Small cell lung cancer_Homo sapiens_hsa052221.23653818
40Pathways in cancer_Homo sapiens_hsa052001.20476087
41Viral myocarditis_Homo sapiens_hsa054161.19643921
42Lysine degradation_Homo sapiens_hsa003101.16489523
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14354677
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13511764
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10072588
46Oocyte meiosis_Homo sapiens_hsa041141.07135040
47PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05119796
48HTLV-I infection_Homo sapiens_hsa051661.03727760
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.03509002
50Gap junction_Homo sapiens_hsa045400.96155815
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.96121213
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95529171
53Selenocompound metabolism_Homo sapiens_hsa004500.94787557
54Renin-angiotensin system_Homo sapiens_hsa046140.93290826
55p53 signaling pathway_Homo sapiens_hsa041150.92985532
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.91664043
57Alcoholism_Homo sapiens_hsa050340.91620717
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91245842
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90309743
60Prolactin signaling pathway_Homo sapiens_hsa049170.89284816
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86339530
62Insulin signaling pathway_Homo sapiens_hsa049100.85363718
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85249525
64Thyroid cancer_Homo sapiens_hsa052160.83280148
65Amoebiasis_Homo sapiens_hsa051460.82986264
66Ras signaling pathway_Homo sapiens_hsa040140.80695206
67Rap1 signaling pathway_Homo sapiens_hsa040150.79960831
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78943020
69Hepatitis B_Homo sapiens_hsa051610.77107675
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76354290
71Shigellosis_Homo sapiens_hsa051310.73625907
72Type II diabetes mellitus_Homo sapiens_hsa049300.68236061
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.66433451
74Tight junction_Homo sapiens_hsa045300.66256737
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64999241
76Circadian entrainment_Homo sapiens_hsa047130.64691822
77Protein digestion and absorption_Homo sapiens_hsa049740.63113888
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62249650
79Calcium signaling pathway_Homo sapiens_hsa040200.61165960
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55924693
81Nitrogen metabolism_Homo sapiens_hsa009100.54661147
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54515884
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53797222
84Viral carcinogenesis_Homo sapiens_hsa052030.51913641
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51257666
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51026328
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50227709
88Long-term depression_Homo sapiens_hsa047300.49692603
89mTOR signaling pathway_Homo sapiens_hsa041500.49207594
90Systemic lupus erythematosus_Homo sapiens_hsa053220.49140579
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48184822
92Sulfur relay system_Homo sapiens_hsa041220.47516825
93One carbon pool by folate_Homo sapiens_hsa006700.46681255
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45165072
95mRNA surveillance pathway_Homo sapiens_hsa030150.44453627
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.44241935
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43474828
98Spliceosome_Homo sapiens_hsa030400.43413183
99cAMP signaling pathway_Homo sapiens_hsa040240.41325820
100Choline metabolism in cancer_Homo sapiens_hsa052310.39231117
101Epstein-Barr virus infection_Homo sapiens_hsa051690.38805852
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.38552296
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37566159
104Chemokine signaling pathway_Homo sapiens_hsa040620.37452576
105Oxytocin signaling pathway_Homo sapiens_hsa049210.37424607
106FoxO signaling pathway_Homo sapiens_hsa040680.37352488
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36928661
108Pyruvate metabolism_Homo sapiens_hsa006200.36745135
109Thyroid hormone synthesis_Homo sapiens_hsa049180.36603111
110Cocaine addiction_Homo sapiens_hsa050300.36448419
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36236826
112Salivary secretion_Homo sapiens_hsa049700.35041187
113MAPK signaling pathway_Homo sapiens_hsa040100.34741156
114Glycerolipid metabolism_Homo sapiens_hsa005610.34570490
115Basal transcription factors_Homo sapiens_hsa030220.34226135
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32830875
117Propanoate metabolism_Homo sapiens_hsa006400.32095769
118Complement and coagulation cascades_Homo sapiens_hsa046100.30058681
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29439294
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.29337005
121Histidine metabolism_Homo sapiens_hsa003400.28840562
122Steroid biosynthesis_Homo sapiens_hsa001000.26897780
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26497365
124Taste transduction_Homo sapiens_hsa047420.26199323
125AMPK signaling pathway_Homo sapiens_hsa041520.26121312
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25830509
127Renin secretion_Homo sapiens_hsa049240.25639155
128Retinol metabolism_Homo sapiens_hsa008300.25625585
129Gastric acid secretion_Homo sapiens_hsa049710.24888246
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22513246

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