PCDH19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Defects in this gene are a cause of epilepsy female-restricted with mental retardation (EFMR). Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)4.97223323
2neuron cell-cell adhesion (GO:0007158)4.84946190
3neuron recognition (GO:0008038)4.77497238
4protein localization to synapse (GO:0035418)4.57923620
5pyrimidine nucleobase catabolic process (GO:0006208)4.56466653
6axonal fasciculation (GO:0007413)4.52785116
7locomotory exploration behavior (GO:0035641)4.40209139
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.35967302
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32170522
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32011503
11exploration behavior (GO:0035640)4.19861300
12dendritic spine morphogenesis (GO:0060997)4.18262847
13glutamate receptor signaling pathway (GO:0007215)4.17657251
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12700443
15layer formation in cerebral cortex (GO:0021819)3.96095934
16regulation of glutamate receptor signaling pathway (GO:1900449)3.92173022
17regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83912802
18synaptic vesicle exocytosis (GO:0016079)3.81572866
19auditory behavior (GO:0031223)3.80704577
20proline transport (GO:0015824)3.77005901
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69436936
22nucleobase catabolic process (GO:0046113)3.68754545
23postsynaptic membrane organization (GO:0001941)3.59146991
24glutamate secretion (GO:0014047)3.50664747
25presynaptic membrane assembly (GO:0097105)3.49027056
26dendrite morphogenesis (GO:0048813)3.47551355
27synaptic vesicle maturation (GO:0016188)3.47074055
28synaptic transmission, glutamatergic (GO:0035249)3.45619825
29regulation of dendritic spine morphogenesis (GO:0061001)3.41574130
30central nervous system myelination (GO:0022010)3.38512455
31axon ensheathment in central nervous system (GO:0032291)3.38512455
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.36530301
33regulation of neuronal synaptic plasticity (GO:0048168)3.35629346
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35087417
35axon extension (GO:0048675)3.30453650
36positive regulation of synapse maturation (GO:0090129)3.30279791
37central nervous system projection neuron axonogenesis (GO:0021952)3.29591970
38positive regulation of synapse assembly (GO:0051965)3.24962609
39neuron-neuron synaptic transmission (GO:0007270)3.23855473
40regulation of synaptic vesicle exocytosis (GO:2000300)3.20428918
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18533937
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17956098
43dendritic spine organization (GO:0097061)3.17810536
44mechanosensory behavior (GO:0007638)3.15672745
45establishment of mitochondrion localization (GO:0051654)3.15291960
46transmission of nerve impulse (GO:0019226)3.13290361
47response to auditory stimulus (GO:0010996)3.13250176
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12893289
49positive regulation of fibroblast migration (GO:0010763)3.12284563
50regulation of postsynaptic membrane potential (GO:0060078)3.05085109
51behavioral fear response (GO:0001662)3.04462415
52behavioral defense response (GO:0002209)3.04462415
53neuronal stem cell maintenance (GO:0097150)3.04003900
54presynaptic membrane organization (GO:0097090)3.01468326
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01415339
56regulation of axon extension involved in axon guidance (GO:0048841)2.99377152
57regulation of dendritic spine development (GO:0060998)2.98024766
58cellular potassium ion homeostasis (GO:0030007)2.97965438
59innervation (GO:0060384)2.97159350
60long-term memory (GO:0007616)2.95778128
61retinal ganglion cell axon guidance (GO:0031290)2.94746422
62positive regulation of dendritic spine morphogenesis (GO:0061003)2.90815783
63fear response (GO:0042596)2.90017675
64regulation of synapse assembly (GO:0051963)2.87880942
65neurotransmitter secretion (GO:0007269)2.86556654
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86490217
67neuronal ion channel clustering (GO:0045161)2.85695880
68cerebral cortex radially oriented cell migration (GO:0021799)2.85027858
69lateral sprouting from an epithelium (GO:0060601)2.84971378
70regulation of axon guidance (GO:1902667)2.84410940
71regulation of synapse structural plasticity (GO:0051823)2.84158054
72neuron projection extension (GO:1990138)2.83257833
73inner ear receptor cell development (GO:0060119)2.82985124
74positive regulation of dendritic spine development (GO:0060999)2.82433429
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81929060
76regulation of synaptic plasticity (GO:0048167)2.80996023
77long-term synaptic potentiation (GO:0060291)2.79726563
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.79596068
79behavioral response to nicotine (GO:0035095)2.79592607
80cell migration in hindbrain (GO:0021535)2.79581778
81neuronal action potential propagation (GO:0019227)2.78176166
82neuron remodeling (GO:0016322)2.78016797
83chondrocyte proliferation (GO:0035988)2.77723605
84regulation of synaptic vesicle transport (GO:1902803)2.77240220
85mitochondrion transport along microtubule (GO:0047497)2.76990404
86establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76990404
87response to histamine (GO:0034776)2.76578239
88regulation of vesicle fusion (GO:0031338)2.76405196
89appendage development (GO:0048736)2.75230741
90limb development (GO:0060173)2.75230741
91sequestering of extracellular ligand from receptor (GO:0035581)2.72938514
92positive regulation of membrane potential (GO:0045838)2.72307580
93sodium ion export (GO:0071436)2.71993854
94synapse organization (GO:0050808)2.71313914
95synaptic vesicle endocytosis (GO:0048488)2.70249579
96regulation of synapse organization (GO:0050807)2.70063696
97neurotransmitter-gated ion channel clustering (GO:0072578)2.69197357
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.69043378
99axon extension involved in axon guidance (GO:0048846)2.69043378
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.68995893
101neuromuscular synaptic transmission (GO:0007274)2.68922195
102regulation of respiratory system process (GO:0044065)2.68336697
103gamma-aminobutyric acid transport (GO:0015812)2.66965661
104negative regulation of axon extension (GO:0030517)2.66908141
105central nervous system neuron axonogenesis (GO:0021955)2.66693922
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66474908
107synapse assembly (GO:0007416)2.66048984
108negative regulation of oligodendrocyte differentiation (GO:0048715)2.65590388
109forebrain neuron differentiation (GO:0021879)2.65161642
110learning (GO:0007612)2.64461335
111negative regulation of axon extension involved in axon guidance (GO:0048843)2.64225637
112startle response (GO:0001964)2.64070143
113limb bud formation (GO:0060174)2.61885796
114membrane depolarization during action potential (GO:0086010)2.61470844
115cerebellar granule cell differentiation (GO:0021707)2.60901995
116positive regulation of axon extension (GO:0045773)2.59015039
117cochlea development (GO:0090102)2.58335296
118dendrite development (GO:0016358)2.58241506
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58072700
120regulation of synapse maturation (GO:0090128)2.58033487
121membrane assembly (GO:0071709)2.57949998
122activation of protein kinase A activity (GO:0034199)2.57063657
123membrane depolarization (GO:0051899)2.54803945
124G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.54205365
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53818703
126positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.52402865
127ephrin receptor signaling pathway (GO:0048013)2.51016863
128regulation of dendrite morphogenesis (GO:0048814)2.50915784
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50300644
130establishment of nucleus localization (GO:0040023)2.49934872
131L-amino acid import (GO:0043092)2.49074730
132regulation of neurotransmitter secretion (GO:0046928)2.48764842
133neurotransmitter transport (GO:0006836)2.48567122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41142683
2GBX2_23144817_ChIP-Seq_PC3_Human3.57692091
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09298141
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05688748
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02808690
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78039839
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78039839
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75597676
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.67278944
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65832213
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65369963
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.60680423
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58465134
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57796410
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37915109
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36900054
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21710855
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.13445800
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06610340
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.05579934
21AR_21572438_ChIP-Seq_LNCaP_Human2.05396646
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.03309888
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98486454
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95549997
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87477223
26REST_21632747_ChIP-Seq_MESCs_Mouse1.87438552
27DROSHA_22980978_ChIP-Seq_HELA_Human1.87247253
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84175540
29TAF15_26573619_Chip-Seq_HEK293_Human1.82578247
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78195221
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77731960
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71386977
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70446460
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70399025
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67751946
36ZNF274_21170338_ChIP-Seq_K562_Hela1.67056589
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63427419
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.62266856
39* CBX2_27304074_Chip-Seq_ESCs_Mouse1.62250109
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62086779
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.62042610
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61742447
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59604333
44P300_19829295_ChIP-Seq_ESCs_Human1.59314052
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.59186636
46TP53_18474530_ChIP-ChIP_U2OS_Human1.50604332
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.50202721
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48070715
49FUS_26573619_Chip-Seq_HEK293_Human1.47397634
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43613023
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42925325
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42023987
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.41737012
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41686776
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39602559
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39112186
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37594121
58TP53_16413492_ChIP-PET_HCT116_Human1.37209083
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37178510
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36162761
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.35474943
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34582396
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34486869
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30108112
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29061866
66IGF1R_20145208_ChIP-Seq_DFB_Human1.28459498
67* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27120054
68AR_25329375_ChIP-Seq_VCAP_Human1.26595693
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.24472519
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.24339480
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24041538
72RNF2_27304074_Chip-Seq_NSC_Mouse1.22087403
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21573818
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20878181
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.19857062
76JUN_21703547_ChIP-Seq_K562_Human1.16019646
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.15880853
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15706798
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15252047
80AHR_22903824_ChIP-Seq_MCF-7_Human1.15233307
81SOX9_26525672_Chip-Seq_HEART_Mouse1.15157762
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14992618
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14966922
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14768981
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14124271
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13273695
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13148998
88STAT3_23295773_ChIP-Seq_U87_Human1.12705653
89AR_19668381_ChIP-Seq_PC3_Human1.12419023
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11354444
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11354444
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10382107
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08813927
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08636432
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08283788
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.08174880
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07834280
98BCAT_22108803_ChIP-Seq_LS180_Human1.07623417
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.07458437
100EWS_26573619_Chip-Seq_HEK293_Human1.06909603
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06357642
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.06285910
103ER_23166858_ChIP-Seq_MCF-7_Human1.05779911
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05342736
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.04785761
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04330239
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03860643
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02790361
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.02449523
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01050362
111TCF4_23295773_ChIP-Seq_U87_Human0.99212816
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98511015
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.98359207
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97534727
115VDR_22108803_ChIP-Seq_LS180_Human0.97326256
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.95884627
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94421264
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.92516858
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92368653
120TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91695150
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91339694
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91339291
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91339291
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91022821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06527947
2MP0003880_abnormal_central_pattern4.46796780
3MP0003635_abnormal_synaptic_transmissio3.30011570
4MP0008438_abnormal_cutaneous_collagen2.77434108
5MP0004270_analgesia2.75087560
6MP0002063_abnormal_learning/memory/cond2.70816935
7MP0009745_abnormal_behavioral_response2.57063693
8MP0005623_abnormal_meninges_morphology2.51567148
9MP0000566_synostosis2.45021183
10MP0001968_abnormal_touch/_nociception2.24350123
11MP0002064_seizures2.23961808
12MP0002572_abnormal_emotion/affect_behav2.23226938
13MP0000778_abnormal_nervous_system2.21206424
14MP0006292_abnormal_olfactory_placode2.16855625
15MP0003136_yellow_coat_color2.13804835
16MP0005503_abnormal_tendon_morphology2.06601525
17MP0005423_abnormal_somatic_nervous2.01454043
18MP0009780_abnormal_chondrocyte_physiolo1.90577373
19MP0002734_abnormal_mechanical_nocicepti1.88995341
20MP0006276_abnormal_autonomic_nervous1.86978861
21MP0003122_maternal_imprinting1.86906425
22MP0009046_muscle_twitch1.86775510
23MP0001501_abnormal_sleep_pattern1.85076641
24MP0002736_abnormal_nociception_after1.84250171
25MP0001486_abnormal_startle_reflex1.84184296
26MP0002272_abnormal_nervous_system1.84128771
27MP0002822_catalepsy1.81953918
28MP0001440_abnormal_grooming_behavior1.81126346
29MP0004133_heterotaxia1.80644948
30MP0002653_abnormal_ependyma_morphology1.77058649
31MP0001188_hyperpigmentation1.75506049
32MP0002735_abnormal_chemical_nociception1.74864800
33MP0002184_abnormal_innervation1.73395707
34MP0005171_absent_coat_pigmentation1.67052289
35MP0005275_abnormal_skin_tensile1.62701712
36MP0009379_abnormal_foot_pigmentation1.60987863
37MP0004858_abnormal_nervous_system1.58226012
38MP0003890_abnormal_embryonic-extraembry1.55836437
39MP0009053_abnormal_anal_canal1.50156682
40MP0000751_myopathy1.49285348
41MP0003329_amyloid_beta_deposits1.47956723
42MP0010030_abnormal_orbit_morphology1.47107003
43MP0004272_abnormal_basement_membrane1.46603349
44MP0002733_abnormal_thermal_nociception1.42540681
45MP0002067_abnormal_sensory_capabilities1.42298845
46MP0002638_abnormal_pupillary_reflex1.41223325
47MP0002557_abnormal_social/conspecific_i1.39632319
48MP0003385_abnormal_body_wall1.38888082
49MP0001970_abnormal_pain_threshold1.32316845
50MP0004811_abnormal_neuron_physiology1.28514135
51MP0001485_abnormal_pinna_reflex1.27552767
52MP0000955_abnormal_spinal_cord1.26566162
53MP0000026_abnormal_inner_ear1.24723354
54MP0009250_abnormal_appendicular_skeleto1.23933065
55MP0002837_dystrophic_cardiac_calcinosis1.23603594
56MP0001299_abnormal_eye_distance/1.23039501
57MP0003279_aneurysm1.22628148
58MP0002882_abnormal_neuron_morphology1.21383216
59MP0005386_behavior/neurological_phenoty1.18605402
60MP0004924_abnormal_behavior1.18605402
61MP0003119_abnormal_digestive_system1.16483614
62MP0004145_abnormal_muscle_electrophysio1.14606318
63MP0001346_abnormal_lacrimal_gland1.13422433
64MP0001963_abnormal_hearing_physiology1.10834242
65MP0001502_abnormal_circadian_rhythm1.08625613
66MP0000579_abnormal_nail_morphology1.08073638
67MP0002066_abnormal_motor_capabilities/c1.07954762
68MP0001293_anophthalmia1.07933708
69MP0002152_abnormal_brain_morphology1.07405506
70MP0005248_abnormal_Harderian_gland1.06847216
71MP0008789_abnormal_olfactory_epithelium1.06083179
72MP0003937_abnormal_limbs/digits/tail_de1.05118126
73MP0005645_abnormal_hypothalamus_physiol1.05057068
74MP0002233_abnormal_nose_morphology1.03898173
75MP0001984_abnormal_olfaction1.03868516
76MP0002938_white_spotting1.03527509
77MP0002295_abnormal_pulmonary_circulatio1.01630126
78MP0000013_abnormal_adipose_tissue1.01586728
79MP0004484_altered_response_of1.00688694
80MP0004233_abnormal_muscle_weight1.00391083
81MP0001958_emphysema0.99683392
82MP0009384_cardiac_valve_regurgitation0.96851074
83MP0010368_abnormal_lymphatic_system0.95345104
84MP0002108_abnormal_muscle_morphology0.95277408
85MP0001177_atelectasis0.94521802
86MP0001905_abnormal_dopamine_level0.93829837
87MP0003879_abnormal_hair_cell0.93584688
88MP0004885_abnormal_endolymph0.93473587
89MP0008569_lethality_at_weaning0.91199224
90MP0005187_abnormal_penis_morphology0.91052004
91MP0003755_abnormal_palate_morphology0.90337258
92MP0005551_abnormal_eye_electrophysiolog0.89263070
93MP0005409_darkened_coat_color0.89132665
94MP0003123_paternal_imprinting0.88784322
95MP0000049_abnormal_middle_ear0.87820100
96MP0003787_abnormal_imprinting0.87358986
97MP0004085_abnormal_heartbeat0.85503539
98MP0002081_perinatal_lethality0.85498877
99MP0003861_abnormal_nervous_system0.84234604
100MP0005595_abnormal_vascular_smooth0.83923516
101MP0003938_abnormal_ear_development0.83843888
102MP0001286_abnormal_eye_development0.83535705
103MP0004742_abnormal_vestibular_system0.83465832
104MP0002234_abnormal_pharynx_morphology0.82695560
105MP0002697_abnormal_eye_size0.82643525
106MP0003705_abnormal_hypodermis_morpholog0.82394115
107MP0001529_abnormal_vocalization0.81567328
108MP0003091_abnormal_cell_migration0.81204187
109MP0003942_abnormal_urinary_system0.80655657
110MP0005508_abnormal_skeleton_morphology0.79745226
111MP0000631_abnormal_neuroendocrine_gland0.79193166
112MP0004142_abnormal_muscle_tone0.79175117
113MP0001348_abnormal_lacrimal_gland0.79159949
114MP0004215_abnormal_myocardial_fiber0.78578245
115MP0002102_abnormal_ear_morphology0.77267240
116MP0003633_abnormal_nervous_system0.77241471
117MP0003121_genomic_imprinting0.76836975
118MP0000534_abnormal_ureter_morphology0.76132124
119MP0002752_abnormal_somatic_nervous0.75487842
120MP0000537_abnormal_urethra_morphology0.75443009
121MP0003283_abnormal_digestive_organ0.74578250
122MP0004134_abnormal_chest_morphology0.73365330
123MP0002249_abnormal_larynx_morphology0.73318650
124MP0005195_abnormal_posterior_eye0.72851522
125MP0003634_abnormal_glial_cell0.72514884
126MP0008877_abnormal_DNA_methylation0.72262654
127MP0005646_abnormal_pituitary_gland0.71091225
128MP0002909_abnormal_adrenal_gland0.70023202
129MP0002896_abnormal_bone_mineralization0.69846830
130MP0001879_abnormal_lymphatic_vessel0.68759997
131MP0005394_taste/olfaction_phenotype0.68471363
132MP0005499_abnormal_olfactory_system0.68471363
133MP0002116_abnormal_craniofacial_bone0.67217781
134MP0003137_abnormal_impulse_conducting0.66877041

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.58088215
2Protrusio acetabuli (HP:0003179)4.19164294
3Premature rupture of membranes (HP:0001788)3.89532268
4* Focal seizures (HP:0007359)3.59446451
5Visual hallucinations (HP:0002367)3.53434531
6Epileptic encephalopathy (HP:0200134)3.27377335
7Myokymia (HP:0002411)3.23023012
8Shallow orbits (HP:0000586)3.17719144
9Progressive cerebellar ataxia (HP:0002073)3.04138007
10Cerebral inclusion bodies (HP:0100314)2.92562503
11Septo-optic dysplasia (HP:0100842)2.89809878
12Hyperventilation (HP:0002883)2.86378615
13Split foot (HP:0001839)2.76547629
14Buphthalmos (HP:0000557)2.75693133
15Short 4th metacarpal (HP:0010044)2.72907445
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72907445
17Excessive salivation (HP:0003781)2.66610646
18Drooling (HP:0002307)2.66610646
19Cutaneous finger syndactyly (HP:0010554)2.61257775
20Overgrowth (HP:0001548)2.60831527
21Amblyopia (HP:0000646)2.58734385
22Abnormality of the aortic arch (HP:0012303)2.57520606
23Abnormality of dentin (HP:0010299)2.56230687
24Esophageal atresia (HP:0002032)2.55651318
25Abnormality of the 4th metacarpal (HP:0010012)2.53681084
26Febrile seizures (HP:0002373)2.51661961
27Broad-based gait (HP:0002136)2.45374791
28Optic nerve hypoplasia (HP:0000609)2.39918774
29Neurofibrillary tangles (HP:0002185)2.39633818
30Cutaneous syndactyly (HP:0012725)2.39503153
31Oligodactyly (hands) (HP:0001180)2.37336232
32* Absence seizures (HP:0002121)2.36700417
33High anterior hairline (HP:0009890)2.36456595
34Nephronophthisis (HP:0000090)2.35357923
35Broad metatarsal (HP:0001783)2.28262033
36Aplasia involving bones of the extremities (HP:0009825)2.27543111
37Aplasia involving bones of the upper limbs (HP:0009823)2.27543111
38Aplasia of the phalanges of the hand (HP:0009802)2.27543111
39Oligodactyly (HP:0012165)2.25718273
40Termporal pattern (HP:0011008)2.24942649
41Insidious onset (HP:0003587)2.24942649
42* Atonic seizures (HP:0010819)2.22800169
43Lower limb amyotrophy (HP:0007210)2.22597232
44Hypoventilation (HP:0002791)2.21751636
45Hydroureter (HP:0000072)2.21196649
46Mutism (HP:0002300)2.19722639
47Aortic dissection (HP:0002647)2.16649523
48Morphological abnormality of the middle ear (HP:0008609)2.15776166
49Infantile muscular hypotonia (HP:0008947)2.15506056
50Abnormality of the diencephalon (HP:0010662)2.14729872
51Narrow nasal bridge (HP:0000446)2.12229774
52Coronal craniosynostosis (HP:0004440)2.11426590
53Absent speech (HP:0001344)2.10944040
54* Dialeptic seizures (HP:0011146)2.10824843
55Wrist flexion contracture (HP:0001239)2.10070406
56Vascular tortuosity (HP:0004948)2.09842289
57Absent septum pellucidum (HP:0001331)2.09772415
58Genetic anticipation (HP:0003743)2.09167087
59Supranuclear gaze palsy (HP:0000605)2.09077329
60Genu recurvatum (HP:0002816)2.06389431
61Pancreatic fibrosis (HP:0100732)2.05312791
62Rib fusion (HP:0000902)2.03179482
63* Generalized tonic-clonic seizures (HP:0002069)2.02022894
64Hepatoblastoma (HP:0002884)2.01895707
65Dilatation of the ascending aorta (HP:0005111)2.01854998
66Abnormality of the labia minora (HP:0012880)2.00656773
67Abnormality of the lower motor neuron (HP:0002366)1.98832526
68Increased variability in muscle fiber diameter (HP:0003557)1.98341571
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98295327
70Gastrointestinal atresia (HP:0002589)1.98224626
71Gait imbalance (HP:0002141)1.96952431
72Poor eye contact (HP:0000817)1.96645498
73Fragile skin (HP:0001030)1.95437006
74Arterial tortuosity (HP:0005116)1.95003235
75Bladder diverticulum (HP:0000015)1.93809971
76Truncal ataxia (HP:0002078)1.93781108
77Action tremor (HP:0002345)1.93461085
78Atrophic scars (HP:0001075)1.92997151
79Hyperextensible skin (HP:0000974)1.92950134
80Dysdiadochokinesis (HP:0002075)1.92587217
81Soft skin (HP:0000977)1.91855346
82Aqueductal stenosis (HP:0002410)1.91148597
83True hermaphroditism (HP:0010459)1.90909286
84Congenital glaucoma (HP:0001087)1.89940344
85Abnormality of the corticospinal tract (HP:0002492)1.89147103
86Bronchomalacia (HP:0002780)1.87037215
87Limb dystonia (HP:0002451)1.86030552
88Anophthalmia (HP:0000528)1.84038993
89Abnormality of midbrain morphology (HP:0002418)1.83807440
90Molar tooth sign on MRI (HP:0002419)1.83807440
91Neonatal short-limb short stature (HP:0008921)1.83613773
92Amyotrophic lateral sclerosis (HP:0007354)1.83311343
93Renal hypoplasia (HP:0000089)1.83058348
94Hemiparesis (HP:0001269)1.82449020
95Diplopia (HP:0000651)1.82258262
96Abnormality of binocular vision (HP:0011514)1.82258262
97Retinal dysplasia (HP:0007973)1.81685886
98Renal dysplasia (HP:0000110)1.81633375
99Abnormality of salivation (HP:0100755)1.81456031
100Partial duplication of thumb phalanx (HP:0009944)1.81319315
101Maternal diabetes (HP:0009800)1.81091900
102Epileptiform EEG discharges (HP:0011182)1.81053171
103Venous insufficiency (HP:0005293)1.79377142
104Abnormal social behavior (HP:0012433)1.79049934
105Impaired social interactions (HP:0000735)1.79049934
106Trigonocephaly (HP:0000243)1.78856247
107Cortical dysplasia (HP:0002539)1.77991197
108Exotropia (HP:0000577)1.77453595
109Mitral valve prolapse (HP:0001634)1.77306720
110Partial duplication of the phalanx of hand (HP:0009999)1.76572229
111Abnormality of the renal medulla (HP:0100957)1.76564832
112Hypsarrhythmia (HP:0002521)1.76453543
113Dysmetria (HP:0001310)1.76170630
114Anxiety (HP:0000739)1.75831207
115Agitation (HP:0000713)1.75205362
116Abnormal eating behavior (HP:0100738)1.74394431
117Ankle contracture (HP:0006466)1.73685538
118Slender build (HP:0001533)1.73574262
119Megalencephaly (HP:0001355)1.72684685
120Open mouth (HP:0000194)1.72294026
121Polyphagia (HP:0002591)1.72216683
122Peritonitis (HP:0002586)1.71560507
123Fetal akinesia sequence (HP:0001989)1.71328968
124Delayed gross motor development (HP:0002194)1.71181814
125Ankyloglossia (HP:0010296)1.71128350
126Intestinal atresia (HP:0011100)1.70934671
127Obstructive sleep apnea (HP:0002870)1.70518227
128Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70305266
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70231132
130Hypoplasia of the brainstem (HP:0002365)1.70231132
131Impaired vibration sensation in the lower limbs (HP:0002166)1.70093157
132Progressive inability to walk (HP:0002505)1.70086578
133Depression (HP:0000716)1.69512525
134Sleep apnea (HP:0010535)1.69086233
135Abnormality of the septum pellucidum (HP:0007375)1.68954871
136Stereotypic behavior (HP:0000733)1.68910065
137Papilledema (HP:0001085)1.68307522
138Cerebral aneurysm (HP:0004944)1.67721711
139Urinary bladder sphincter dysfunction (HP:0002839)1.67349531
140EEG with generalized epileptiform discharges (HP:0011198)1.66413672
141Broad ribs (HP:0000885)1.66233733
142Intellectual disability, moderate (HP:0002342)1.65976627
143Pancreatic cysts (HP:0001737)1.65822057
144Specific learning disability (HP:0001328)1.65541998
145Spinal rigidity (HP:0003306)1.65368273
146Supernumerary spleens (HP:0009799)1.64456432
147Anencephaly (HP:0002323)1.63983055
148Turricephaly (HP:0000262)1.63609656
149Overriding aorta (HP:0002623)1.63008279
150Spastic gait (HP:0002064)1.60670459
151Postaxial hand polydactyly (HP:0001162)1.59343004
152Chronic hepatic failure (HP:0100626)1.58850692
153Morphological abnormality of the pyramidal tract (HP:0002062)1.58164359
154Volvulus (HP:0002580)1.57137453
155Sacral dimple (HP:0000960)1.56900746
156Hemiplegia (HP:0002301)1.55901384
157Chorioretinal coloboma (HP:0000567)1.54348551
158Abdominal situs inversus (HP:0003363)1.53998613
159Abnormality of abdominal situs (HP:0011620)1.53998613
160Preaxial foot polydactyly (HP:0001841)1.53977527
161Midline defect of the nose (HP:0004122)1.53308863
162Vitreoretinal degeneration (HP:0000655)1.52823222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.12260291
2EPHA44.01228032
3MARK13.99442097
4MAP3K92.64308011
5MAP3K42.62405796
6CASK2.60000937
7MINK12.52040486
8LATS22.38177562
9PLK22.22745336
10MAP2K72.12711331
11PNCK2.09049399
12PAK61.94766237
13NTRK21.88834331
14PINK11.85323576
15DDR21.81375901
16MAPK131.80013502
17NTRK11.72688664
18TNIK1.70698975
19MAP3K121.68547347
20MAP4K21.67011129
21PAK31.63491578
22PTK2B1.60153143
23KSR11.56924304
24GRK51.54751190
25MAP2K41.49965157
26SIK21.41122331
27CCNB11.40130668
28FER1.38513917
29CAMK2A1.32810754
30PRPF4B1.30893471
31CDK51.30015873
32MKNK21.25255484
33DMPK1.24363467
34RIPK41.23684175
35PRKCG1.23239658
36PHKG11.22405067
37PHKG21.22405067
38PRKD31.20315943
39EPHB21.18103746
40WNK31.18002660
41CAMK1D1.17472266
42FGR1.15869700
43CDK191.13966697
44DAPK21.11973819
45PDGFRA1.11487327
46MAPK151.10961194
47KSR21.10331651
48NME11.08430230
49WNK41.07927220
50CAMK2B1.01487071
51CDK141.00063656
52ERBB30.99768419
53FES0.99331250
54UHMK10.98314424
55INSRR0.95087887
56ARAF0.92564114
57TYRO30.91999999
58CSNK1G20.91155612
59SGK4940.88910680
60SGK2230.88910680
61TSSK60.88070560
62CDK180.87248967
63CDK150.86557565
64STK38L0.86304811
65DAPK10.84516270
66MKNK10.84220602
67CAMKK10.82488709
68PRKCE0.80090093
69DYRK20.79454578
70ROCK20.78926425
71BCR0.74832508
72DYRK1A0.73799129
73CDK11A0.73094978
74CAMK2D0.70803994
75BRD40.69836641
76MAP3K50.68958341
77SGK20.68676728
78EPHA30.68297121
79FGFR20.67372181
80PRKCH0.67133894
81RET0.67035921
82MARK20.66218539
83LATS10.66120952
84MOS0.65499068
85MAP2K60.65022912
86CAMK1G0.64094161
87ADRBK10.62922331
88AKT30.62870362
89STK380.61336456
90PKN10.60943689
91TTN0.60761110
92CAMK40.59441675
93ROCK10.59337674
94STK110.59229848
95BMPR20.58745356
96SGK10.56470219
97CSNK1G10.56075596
98MAP2K10.55812442
99CAMK10.55234444
100PTK20.54828620
101BMPR1B0.52522115
102MAP3K60.52412678
103RAF10.52400387
104PAK20.50695724
105MAP3K20.50330299
106WEE10.49711788
107TLK10.49368207
108PRKCZ0.49355374
109FYN0.49155002
110PIK3CA0.49011689
111CSNK1A1L0.46256536
112MUSK0.46122633
113STK390.44726693
114CDK30.44328791
115CSNK1G30.43648315
116TIE10.40330608
117OXSR10.40187831
118ERBB20.39232027
119TRIM280.38289059
120ALK0.37169217
121CSNK1D0.36957810
122MAPK100.36565488
123BRAF0.36110911
124CAMK2G0.35565028
125WNK10.35511207
126DYRK1B0.34763654
127TAOK20.34640119
128NEK60.34561013
129FRK0.34437705
130PRKD20.33583041
131PRKG10.33404921
132MAPK120.32996660
133PDGFRB0.32775458
134GRK70.32764935
135RPS6KA30.32583859
136CSNK1E0.30959412
137RPS6KA20.27909008

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73435457
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51175891
3Long-term potentiation_Homo sapiens_hsa047202.51052296
4Glutamatergic synapse_Homo sapiens_hsa047242.37439569
5Circadian entrainment_Homo sapiens_hsa047132.36541531
6GABAergic synapse_Homo sapiens_hsa047272.32449148
7Amphetamine addiction_Homo sapiens_hsa050312.18968424
8Morphine addiction_Homo sapiens_hsa050322.14667383
9Synaptic vesicle cycle_Homo sapiens_hsa047212.08272948
10Olfactory transduction_Homo sapiens_hsa047402.00295754
11Dopaminergic synapse_Homo sapiens_hsa047281.98724738
12Axon guidance_Homo sapiens_hsa043601.93453939
13Salivary secretion_Homo sapiens_hsa049701.93020350
14Serotonergic synapse_Homo sapiens_hsa047261.84329349
15Long-term depression_Homo sapiens_hsa047301.80712386
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74525725
17Taste transduction_Homo sapiens_hsa047421.72575084
18Renin secretion_Homo sapiens_hsa049241.68970410
19Cholinergic synapse_Homo sapiens_hsa047251.64590530
20Oxytocin signaling pathway_Homo sapiens_hsa049211.60228741
21Gap junction_Homo sapiens_hsa045401.57609753
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54404389
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53892801
24Gastric acid secretion_Homo sapiens_hsa049711.53797970
25Calcium signaling pathway_Homo sapiens_hsa040201.51355031
26GnRH signaling pathway_Homo sapiens_hsa049121.48349941
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48170586
28Cocaine addiction_Homo sapiens_hsa050301.47055632
29Insulin secretion_Homo sapiens_hsa049111.45458555
30Melanogenesis_Homo sapiens_hsa049161.36440892
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35038567
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30575242
33Glioma_Homo sapiens_hsa052141.28858942
34Dilated cardiomyopathy_Homo sapiens_hsa054141.26982308
35Estrogen signaling pathway_Homo sapiens_hsa049151.24311218
36cAMP signaling pathway_Homo sapiens_hsa040241.20775757
37ErbB signaling pathway_Homo sapiens_hsa040121.11400960
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11143853
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10933437
40Cardiac muscle contraction_Homo sapiens_hsa042601.09943372
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06701013
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05013566
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02023323
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.01295322
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99013001
46Collecting duct acid secretion_Homo sapiens_hsa049660.98691895
47Vibrio cholerae infection_Homo sapiens_hsa051100.96925264
48Wnt signaling pathway_Homo sapiens_hsa043100.95792528
49ECM-receptor interaction_Homo sapiens_hsa045120.94850227
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92860257
51Focal adhesion_Homo sapiens_hsa045100.91926206
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89284700
53Phototransduction_Homo sapiens_hsa047440.89016603
54Ras signaling pathway_Homo sapiens_hsa040140.88262193
55Rap1 signaling pathway_Homo sapiens_hsa040150.86762477
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86129215
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.85040970
58Oocyte meiosis_Homo sapiens_hsa041140.83544202
59Choline metabolism in cancer_Homo sapiens_hsa052310.82207434
60MAPK signaling pathway_Homo sapiens_hsa040100.81835618
61Alzheimers disease_Homo sapiens_hsa050100.81505043
62Dorso-ventral axis formation_Homo sapiens_hsa043200.81225642
63Notch signaling pathway_Homo sapiens_hsa043300.80383442
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79616458
65Renal cell carcinoma_Homo sapiens_hsa052110.78796647
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74279659
67VEGF signaling pathway_Homo sapiens_hsa043700.74144812
68Type II diabetes mellitus_Homo sapiens_hsa049300.73223232
69Hedgehog signaling pathway_Homo sapiens_hsa043400.70587896
70Melanoma_Homo sapiens_hsa052180.68437319
71Steroid biosynthesis_Homo sapiens_hsa001000.67269461
72Hippo signaling pathway_Homo sapiens_hsa043900.66782000
73Thyroid hormone synthesis_Homo sapiens_hsa049180.66649041
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66647787
75Proteoglycans in cancer_Homo sapiens_hsa052050.66551517
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65708571
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65211175
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64986752
79Bile secretion_Homo sapiens_hsa049760.64768944
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64689607
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63698363
82Colorectal cancer_Homo sapiens_hsa052100.62961697
83Adherens junction_Homo sapiens_hsa045200.62649411
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61891228
85Pancreatic secretion_Homo sapiens_hsa049720.61664882
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.60678129
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59825681
88Endometrial cancer_Homo sapiens_hsa052130.59368825
89Basal transcription factors_Homo sapiens_hsa030220.57379000
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57166846
91Basal cell carcinoma_Homo sapiens_hsa052170.57048819
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56501033
93Amoebiasis_Homo sapiens_hsa051460.54334884
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.54280129
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53821764
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52437137
97Ovarian steroidogenesis_Homo sapiens_hsa049130.52317947
98Alcoholism_Homo sapiens_hsa050340.52299285
99Tight junction_Homo sapiens_hsa045300.51901523
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51136634
101Oxidative phosphorylation_Homo sapiens_hsa001900.49778018
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48547159
103Circadian rhythm_Homo sapiens_hsa047100.48195200
104Prion diseases_Homo sapiens_hsa050200.47504765
105Butanoate metabolism_Homo sapiens_hsa006500.47279849
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47185390
107Glucagon signaling pathway_Homo sapiens_hsa049220.44781388
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43592207
109Vitamin B6 metabolism_Homo sapiens_hsa007500.42732599
110Nitrogen metabolism_Homo sapiens_hsa009100.41668381
111beta-Alanine metabolism_Homo sapiens_hsa004100.41515470
112Bladder cancer_Homo sapiens_hsa052190.39928697
113TGF-beta signaling pathway_Homo sapiens_hsa043500.39807864
114Protein digestion and absorption_Homo sapiens_hsa049740.39608823
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39595562
116AMPK signaling pathway_Homo sapiens_hsa041520.37625242
117MicroRNAs in cancer_Homo sapiens_hsa052060.35150496
118Parkinsons disease_Homo sapiens_hsa050120.34492637

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