PCDH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.26970089
2central nervous system myelination (GO:0022010)9.26970089
3fatty acid elongation (GO:0030497)6.70106523
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.46435919
5myelination (GO:0042552)5.92854475
6ensheathment of neurons (GO:0007272)5.91589926
7axon ensheathment (GO:0008366)5.91589926
8long-chain fatty acid biosynthetic process (GO:0042759)5.62475572
9presynaptic membrane assembly (GO:0097105)5.17716492
10negative regulation of neurotransmitter secretion (GO:0046929)5.07751759
11presynaptic membrane organization (GO:0097090)5.07683310
12negative regulation of neurotransmitter transport (GO:0051589)4.84331990
13neuron cell-cell adhesion (GO:0007158)4.58422671
14gamma-aminobutyric acid transport (GO:0015812)4.42935657
15establishment of mitochondrion localization (GO:0051654)4.17677382
16neurotransmitter-gated ion channel clustering (GO:0072578)4.09881428
17oligodendrocyte differentiation (GO:0048709)4.09077977
18apical protein localization (GO:0045176)4.07352823
19glycerophospholipid catabolic process (GO:0046475)4.06680086
20cholesterol biosynthetic process (GO:0006695)4.00459254
21L-amino acid import (GO:0043092)3.93223257
22negative regulation of protein localization to cell surface (GO:2000009)3.88108411
23startle response (GO:0001964)3.87307825
24myelin maintenance (GO:0043217)3.86521771
25regulation of collateral sprouting (GO:0048670)3.86318567
26membrane depolarization during action potential (GO:0086010)3.85899653
27asymmetric protein localization (GO:0008105)3.78975564
28auditory behavior (GO:0031223)3.76070912
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.75778942
30cellular potassium ion homeostasis (GO:0030007)3.71150112
31eye photoreceptor cell differentiation (GO:0001754)3.63515950
32photoreceptor cell differentiation (GO:0046530)3.63515950
33pyrimidine nucleobase catabolic process (GO:0006208)3.63209649
34astrocyte development (GO:0014002)3.59643302
35neuronal action potential propagation (GO:0019227)3.58803445
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54505860
37response to methylmercury (GO:0051597)3.52143337
38transmission of nerve impulse (GO:0019226)3.50527674
39sterol biosynthetic process (GO:0016126)3.50479105
40C4-dicarboxylate transport (GO:0015740)3.47585766
41cerebellar granule cell differentiation (GO:0021707)3.46353864
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45667353
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.43803954
44adult walking behavior (GO:0007628)3.43660912
45negative regulation of cytosolic calcium ion concentration (GO:0051481)3.42918557
46positive regulation of potassium ion transmembrane transport (GO:1901381)3.42681479
47negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.38702978
48substantia nigra development (GO:0021762)3.38409459
49behavioral response to nicotine (GO:0035095)3.38170638
50positive regulation of synapse maturation (GO:0090129)3.37601861
51positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.36244668
52serotonin metabolic process (GO:0042428)3.32956939
53cerebral cortex radially oriented cell migration (GO:0021799)3.31583125
54response to redox state (GO:0051775)3.30837739
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.30733155
56synaptic vesicle maturation (GO:0016188)3.26357164
57mechanosensory behavior (GO:0007638)3.26316784
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.24922608
59isoprenoid biosynthetic process (GO:0008299)3.19624234
60central nervous system projection neuron axonogenesis (GO:0021952)3.18502496
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.17305490
62long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.17038623
63response to auditory stimulus (GO:0010996)3.15846002
64positive regulation of action potential (GO:0045760)3.15473102
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.14563655
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12203481
67negative regulation of axonogenesis (GO:0050771)3.12058869
68exploration behavior (GO:0035640)3.11658932
69import into cell (GO:0098657)3.11143838
70neuronal action potential (GO:0019228)3.10454177
71primary amino compound metabolic process (GO:1901160)3.09365764
72neuron recognition (GO:0008038)3.08100882
73creatine metabolic process (GO:0006600)3.07493799
74myelination in peripheral nervous system (GO:0022011)3.07042368
75peripheral nervous system axon ensheathment (GO:0032292)3.07042368
76peptidyl-tyrosine autophosphorylation (GO:0038083)3.07041149
77regulation of synapse maturation (GO:0090128)3.02982943
78membrane depolarization (GO:0051899)3.02091276
79nucleobase catabolic process (GO:0046113)3.01853896
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01061842
81cerebellar Purkinje cell differentiation (GO:0021702)3.00984763
82behavioral fear response (GO:0001662)3.00376021
83behavioral defense response (GO:0002209)3.00376021
84magnesium ion transport (GO:0015693)2.99201243
85membrane assembly (GO:0071709)2.97562550
86synapse assembly (GO:0007416)2.97415970
87cellular response to epinephrine stimulus (GO:0071872)2.94344426
88protein palmitoylation (GO:0018345)2.93385695
89amino acid import (GO:0043090)2.92457887
90locomotory exploration behavior (GO:0035641)2.92433730
91protein polyglutamylation (GO:0018095)2.92169075
92regulation of membrane repolarization (GO:0060306)2.91835706
93regulation of postsynaptic membrane potential (GO:0060078)2.91512109
94regulation of glutamate receptor signaling pathway (GO:1900449)2.90196847
95positive regulation of cardiac muscle cell differentiation (GO:2000727)2.89318133
96adhesion of symbiont to host cell (GO:0044650)2.88928232
97virion attachment to host cell (GO:0019062)2.88928232
98dendrite morphogenesis (GO:0048813)2.88464607
99amyloid precursor protein metabolic process (GO:0042982)2.87663282
100neurotransmitter uptake (GO:0001504)2.87286365
101potassium ion import (GO:0010107)2.87096607
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86463706
103limb bud formation (GO:0060174)2.86244135
104neuronal ion channel clustering (GO:0045161)2.85455428
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.84975914
106fear response (GO:0042596)2.84342637
107nerve growth factor signaling pathway (GO:0038180)2.82970307
108regulation of synaptic transmission, GABAergic (GO:0032228)2.82922554
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82729921
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80262825
111fatty-acyl-CoA biosynthetic process (GO:0046949)2.79570182
112axonal fasciculation (GO:0007413)2.79139204
113neuron remodeling (GO:0016322)2.78781947
114membrane tubulation (GO:0097320)2.78131770
115central nervous system neuron axonogenesis (GO:0021955)2.76625879
116negative regulation of axon extension (GO:0030517)2.76260696
117synaptic vesicle docking involved in exocytosis (GO:0016081)2.75969498
118retinal cone cell development (GO:0046549)2.75401289
119glutamate receptor signaling pathway (GO:0007215)2.74763101
120righting reflex (GO:0060013)2.73814684
121protein localization to synapse (GO:0035418)2.73496866
122synaptic vesicle exocytosis (GO:0016079)2.72077826
123regulation of potassium ion transmembrane transport (GO:1901379)2.69730199
124dendritic spine morphogenesis (GO:0060997)2.69593138
125response to epinephrine (GO:0071871)2.68866387
126peripheral nervous system development (GO:0007422)2.68825949
127neuromuscular synaptic transmission (GO:0007274)2.68596533
128regulation of voltage-gated calcium channel activity (GO:1901385)2.68539918
129multicellular organismal signaling (GO:0035637)2.68153907
130neuron-neuron synaptic transmission (GO:0007270)2.66878652
131action potential (GO:0001508)2.66484837
132fatty-acyl-CoA metabolic process (GO:0035337)2.66181964
133glycosphingolipid biosynthetic process (GO:0006688)2.65110876
134response to lipoprotein particle (GO:0055094)2.64768982
135axon development (GO:0061564)2.63999713
136adult behavior (GO:0030534)2.63962915
137synaptic transmission, glutamatergic (GO:0035249)2.63908377
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63884816
139regulation of synaptic vesicle exocytosis (GO:2000300)2.63451597
140positive regulation of potassium ion transport (GO:0043268)2.63049356
141neurotransmitter secretion (GO:0007269)2.63029514
142regulation of action potential (GO:0098900)2.62879240
143GPI anchor metabolic process (GO:0006505)2.62811577
144glycosylceramide metabolic process (GO:0006677)2.60868930
145potassium ion homeostasis (GO:0055075)2.60530566
146GPI anchor biosynthetic process (GO:0006506)2.59657980
147synapse organization (GO:0050808)2.59194725
148postsynaptic membrane organization (GO:0001941)2.58801059
149regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58334337
150synaptic transmission (GO:0007268)2.57392292
151inner ear receptor stereocilium organization (GO:0060122)2.56985629
152regulation of potassium ion transmembrane transporter activity (GO:1901016)2.56118693
153regulation of dendritic spine development (GO:0060998)2.56106289
154negative regulation of synaptic transmission (GO:0050805)2.55983461
155regulation of sarcomere organization (GO:0060297)2.55968473
156detection of temperature stimulus involved in sensory perception (GO:0050961)2.55083099
157detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.55083099
158positive regulation of synapse assembly (GO:0051965)2.53476077
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.53123139
160dendrite development (GO:0016358)2.53015186
161cellular response to catecholamine stimulus (GO:0071870)2.52638827
162cellular response to monoamine stimulus (GO:0071868)2.52638827
163regulation of catecholamine metabolic process (GO:0042069)2.50660775
164regulation of dopamine metabolic process (GO:0042053)2.50660775
165vocalization behavior (GO:0071625)2.49727054
166preassembly of GPI anchor in ER membrane (GO:0016254)2.46715728
167glutamate secretion (GO:0014047)2.45092179
168adult locomotory behavior (GO:0008344)2.44151299
169cyclic nucleotide catabolic process (GO:0009214)2.44085063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.06223726
2EZH2_22144423_ChIP-Seq_EOC_Human3.41011939
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67257092
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59743609
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57760035
6* TAF15_26573619_Chip-Seq_HEK293_Human2.44098768
7* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.36023012
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.29310046
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20323347
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20323347
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15786703
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15054511
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.14271921
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14080360
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13165745
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10968132
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02668822
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00325622
19* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94064014
20AR_21572438_ChIP-Seq_LNCaP_Human1.93553737
21ZNF274_21170338_ChIP-Seq_K562_Hela1.91994788
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89721537
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87740435
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87109638
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86471841
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84889025
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.82345307
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80774738
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75008926
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74904964
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.74714693
32DROSHA_22980978_ChIP-Seq_HELA_Human1.74679012
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73489643
34ER_23166858_ChIP-Seq_MCF-7_Human1.73108132
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69383168
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68955381
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66873781
38VDR_22108803_ChIP-Seq_LS180_Human1.66164092
39* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65062596
40* EWS_26573619_Chip-Seq_HEK293_Human1.64372775
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62103982
42* SMAD3_21741376_ChIP-Seq_EPCs_Human1.61337037
43* REST_21632747_ChIP-Seq_MESCs_Mouse1.60749739
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58178522
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57392357
46* P300_19829295_ChIP-Seq_ESCs_Human1.55815328
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.51859574
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51542951
49* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49355919
50* FUS_26573619_Chip-Seq_HEK293_Human1.47832134
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45383370
52SMAD4_21799915_ChIP-Seq_A2780_Human1.42226681
53* RARB_27405468_Chip-Seq_BRAIN_Mouse1.41275423
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35881502
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35881502
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32861684
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32531685
58* STAT3_23295773_ChIP-Seq_U87_Human1.31243754
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.29639448
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29081564
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.28945603
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.27190736
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25730730
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24448156
65BCAT_22108803_ChIP-Seq_LS180_Human1.21238026
66* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21110357
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.20222567
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.20221567
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19935553
70CBP_20019798_ChIP-Seq_JUKART_Human1.19935553
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19915261
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18971787
73* TCF4_23295773_ChIP-Seq_U87_Human1.18599200
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17939139
75IGF1R_20145208_ChIP-Seq_DFB_Human1.17550476
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13938121
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.13925917
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.13869503
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13824259
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11545517
81* KDM2B_26808549_Chip-Seq_REH_Human1.11300840
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09670395
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.08848763
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08690389
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07182525
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06921914
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06569766
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06540390
89* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06213632
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05812387
91* AR_19668381_ChIP-Seq_PC3_Human1.05408720
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.05383525
93* JUN_21703547_ChIP-Seq_K562_Human1.04507308
94* PRDM14_20953172_ChIP-Seq_ESCs_Human1.04394106
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04103531
96* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03185572
97IRF1_19129219_ChIP-ChIP_H3396_Human1.03146967
98RUNX2_22187159_ChIP-Seq_PCA_Human1.02258470
99* SOX9_26525672_Chip-Seq_HEART_Mouse1.02245844
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01756967
101AR_25329375_ChIP-Seq_VCAP_Human1.01629982
102AHR_22903824_ChIP-Seq_MCF-7_Human1.01301837
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01055012
104P300_18555785_Chip-Seq_ESCs_Mouse1.00986129
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99731036
106E2F1_18555785_Chip-Seq_ESCs_Mouse0.98480287
107TP53_16413492_ChIP-PET_HCT116_Human0.97874299
108* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97015494
109P53_22387025_ChIP-Seq_ESCs_Mouse0.96960619
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96935098
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.96604341
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96216255
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95667177
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95016142
115* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94904301
116* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94904301
117LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93568591
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93344873
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92664003
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.92350496
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91539336
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91375712
123HTT_18923047_ChIP-ChIP_STHdh_Human0.91078690
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.90733262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.80574739
2MP0000920_abnormal_myelination4.26351169
3MP0004270_analgesia3.78887797
4MP0004859_abnormal_synaptic_plasticity3.16718802
5MP0000569_abnormal_digit_pigmentation3.10206904
6MP0001529_abnormal_vocalization2.79201282
7MP0002272_abnormal_nervous_system2.78040627
8MP0003950_abnormal_plasma_membrane2.76992518
9MP0001486_abnormal_startle_reflex2.75647130
10MP0002064_seizures2.66816902
11MP0003635_abnormal_synaptic_transmissio2.57081570
12MP0003690_abnormal_glial_cell2.54134043
13MP0009046_muscle_twitch2.53359964
14MP0004742_abnormal_vestibular_system2.43187099
15MP0003329_amyloid_beta_deposits2.41984319
16MP0009745_abnormal_behavioral_response2.40095430
17MP0000778_abnormal_nervous_system2.38448946
18MP0001905_abnormal_dopamine_level2.34439501
19MP0004885_abnormal_endolymph2.26915883
20MP0002734_abnormal_mechanical_nocicepti2.24056117
21MP0004142_abnormal_muscle_tone2.15363902
22MP0005423_abnormal_somatic_nervous2.11259584
23MP0003634_abnormal_glial_cell2.01826239
24MP0002572_abnormal_emotion/affect_behav2.00097439
25MP0001485_abnormal_pinna_reflex1.99015497
26MP0002063_abnormal_learning/memory/cond1.97839807
27MP0005171_absent_coat_pigmentation1.96808204
28MP0003136_yellow_coat_color1.94272128
29MP0001440_abnormal_grooming_behavior1.84869126
30MP0005409_darkened_coat_color1.79854012
31MP0002229_neurodegeneration1.78694101
32MP0002067_abnormal_sensory_capabilities1.71591160
33MP0001968_abnormal_touch/_nociception1.69643671
34MP0003879_abnormal_hair_cell1.69541613
35MP0005551_abnormal_eye_electrophysiolog1.68191263
36MP0003632_abnormal_nervous_system1.62103255
37MP0000955_abnormal_spinal_cord1.58772364
38MP0002638_abnormal_pupillary_reflex1.55425132
39MP0005386_behavior/neurological_phenoty1.54864081
40MP0004924_abnormal_behavior1.54864081
41MP0002882_abnormal_neuron_morphology1.54366747
42MP0001970_abnormal_pain_threshold1.53329392
43MP0005410_abnormal_fertilization1.52319912
44MP0002736_abnormal_nociception_after1.49037975
45MP0002735_abnormal_chemical_nociception1.46395922
46MP0008569_lethality_at_weaning1.45337351
47MP0002733_abnormal_thermal_nociception1.41924192
48MP0010386_abnormal_urinary_bladder1.41717235
49MP0002066_abnormal_motor_capabilities/c1.39831399
50MP0001501_abnormal_sleep_pattern1.37303610
51MP0003631_nervous_system_phenotype1.36640447
52MP0001963_abnormal_hearing_physiology1.27796214
53MP0002752_abnormal_somatic_nervous1.25112450
54MP0000462_abnormal_digestive_system1.24240897
55MP0003633_abnormal_nervous_system1.23919291
56MP0002184_abnormal_innervation1.23367328
57MP0006292_abnormal_olfactory_placode1.20351679
58MP0004043_abnormal_pH_regulation1.17918438
59MP0008877_abnormal_DNA_methylation1.16035749
60MP0005646_abnormal_pituitary_gland1.14314790
61MP0001984_abnormal_olfaction1.13352845
62MP0000604_amyloidosis1.12012824
63MP0006276_abnormal_autonomic_nervous1.10050462
64MP0002557_abnormal_social/conspecific_i1.09769041
65MP0002102_abnormal_ear_morphology1.09746080
66MP0003122_maternal_imprinting1.08991137
67MP0010678_abnormal_skin_adnexa1.08278158
68MP0004134_abnormal_chest_morphology1.07510144
69MP0004145_abnormal_muscle_electrophysio1.07294940
70MP0001502_abnormal_circadian_rhythm1.07069622
71MP0000383_abnormal_hair_follicle1.06046308
72MP0005451_abnormal_body_composition1.05428422
73MP0008872_abnormal_physiological_respon1.05230488
74MP0004215_abnormal_myocardial_fiber1.03751241
75MP0004133_heterotaxia1.03597925
76MP0008260_abnormal_autophagy1.03066521
77MP0003938_abnormal_ear_development1.02843528
78MP0002152_abnormal_brain_morphology1.02398894
79MP0001299_abnormal_eye_distance/1.01811764
80MP0005645_abnormal_hypothalamus_physiol1.01434730
81MP0004147_increased_porphyrin_level1.00911819
82MP0005174_abnormal_tail_pigmentation0.99303865
83MP0002234_abnormal_pharynx_morphology0.97952618
84MP0002751_abnormal_autonomic_nervous0.95869001
85MP0000026_abnormal_inner_ear0.95116663
86MP0004381_abnormal_hair_follicle0.93711211
87MP0005195_abnormal_posterior_eye0.93641460
88MP0004130_abnormal_muscle_cell0.93068866
89MP0006072_abnormal_retinal_apoptosis0.92952809
90MP0005187_abnormal_penis_morphology0.92883320
91MP0002822_catalepsy0.89803833
92MP0004811_abnormal_neuron_physiology0.89609630
93MP0001177_atelectasis0.84660411
94MP0005253_abnormal_eye_physiology0.84542640
95MP0001986_abnormal_taste_sensitivity0.83547378
96MP0001661_extended_life_span0.82986081
97MP0009780_abnormal_chondrocyte_physiolo0.82930587
98MP0000566_synostosis0.82147235
99MP0002160_abnormal_reproductive_system0.81029857
100MP0000747_muscle_weakness0.80999961
101MP0000631_abnormal_neuroendocrine_gland0.79606122
102MP0001188_hyperpigmentation0.79596344
103MP0001346_abnormal_lacrimal_gland0.78459180
104MP0003121_genomic_imprinting0.78240260
105MP0002876_abnormal_thyroid_physiology0.73140332
106MP0002090_abnormal_vision0.72875836
107MP0003119_abnormal_digestive_system0.72736719
108MP0005623_abnormal_meninges_morphology0.72635065
109MP0002095_abnormal_skin_pigmentation0.69657731
110MP0003937_abnormal_limbs/digits/tail_de0.68606844
111MP0000049_abnormal_middle_ear0.68327098
112MP0003137_abnormal_impulse_conducting0.68157742
113MP0003787_abnormal_imprinting0.65198600
114MP0000647_abnormal_sebaceous_gland0.63346828
115MP0002909_abnormal_adrenal_gland0.61688995
116MP0004036_abnormal_muscle_relaxation0.61004708
117MP0001348_abnormal_lacrimal_gland0.60735564
118MP0003861_abnormal_nervous_system0.60224493
119MP0002653_abnormal_ependyma_morphology0.59722975
120MP0004085_abnormal_heartbeat0.58663937
121MP0001943_abnormal_respiration0.58238392
122MP0001664_abnormal_digestion0.57836971
123MP0000534_abnormal_ureter_morphology0.57537522
124MP0010770_preweaning_lethality0.57044873
125MP0001851_eye_inflammation0.56782445
126MP0002069_abnormal_eating/drinking_beha0.56686338
127MP0000762_abnormal_tongue_morphology0.54929703

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.45974893
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.45974893
3Neurofibrillary tangles (HP:0002185)5.74706374
4Abnormality of the corticospinal tract (HP:0002492)5.05919561
5Febrile seizures (HP:0002373)4.70444340
6Sensory axonal neuropathy (HP:0003390)4.69428997
7Parakeratosis (HP:0001036)4.39455985
8Cerebral inclusion bodies (HP:0100314)4.24857289
9Peripheral hypomyelination (HP:0007182)3.91551906
10Supranuclear gaze palsy (HP:0000605)3.79292203
11Spastic gait (HP:0002064)3.74593010
12Focal motor seizures (HP:0011153)3.61403448
13Termporal pattern (HP:0011008)3.53680097
14Insidious onset (HP:0003587)3.53680097
15Hemiparesis (HP:0001269)3.46630123
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41579051
17Myokymia (HP:0002411)3.39419863
18Dysmetria (HP:0001310)3.36103433
19Onion bulb formation (HP:0003383)3.24093354
20Akinesia (HP:0002304)3.15761798
21True hermaphroditism (HP:0010459)3.11486250
22Epileptic encephalopathy (HP:0200134)3.09824275
23Drooling (HP:0002307)3.03749882
24Pancreatic fibrosis (HP:0100732)3.02222277
25Atonic seizures (HP:0010819)3.01439884
26Intention tremor (HP:0002080)3.00513967
27Cerebral hypomyelination (HP:0006808)2.92040097
28Scanning speech (HP:0002168)2.91938074
29Nephronophthisis (HP:0000090)2.91074908
30Retinal dysplasia (HP:0007973)2.89200949
31Genetic anticipation (HP:0003743)2.88142705
32Pancreatic cysts (HP:0001737)2.87955631
33Ankle clonus (HP:0011448)2.87065561
34Alacrima (HP:0000522)2.83190826
35Excessive salivation (HP:0003781)2.75729421
36Thickened helices (HP:0000391)2.70261535
37Abolished electroretinogram (ERG) (HP:0000550)2.69292347
38Inability to walk (HP:0002540)2.66516659
39Abnormality of glycolysis (HP:0004366)2.65969921
40Increased serum pyruvate (HP:0003542)2.65969921
41Abnormal auditory evoked potentials (HP:0006958)2.64008740
42Pheochromocytoma (HP:0002666)2.60340949
43Hemiplegia (HP:0002301)2.59925825
44Medial flaring of the eyebrow (HP:0010747)2.59166513
45Abnormality of midbrain morphology (HP:0002418)2.56885349
46Molar tooth sign on MRI (HP:0002419)2.56885349
47Slow saccadic eye movements (HP:0000514)2.52871881
48Hyperventilation (HP:0002883)2.52027043
49Abnormality of binocular vision (HP:0011514)2.51705759
50Diplopia (HP:0000651)2.51705759
51Clumsiness (HP:0002312)2.51177503
52Autoamputation (HP:0001218)2.50268781
53Focal seizures (HP:0007359)2.49941464
54Polyphagia (HP:0002591)2.45216727
55Impaired vibration sensation in the lower limbs (HP:0002166)2.44388011
56Abnormality of the renal medulla (HP:0100957)2.42327936
57Lower limb muscle weakness (HP:0007340)2.41997935
58Broad-based gait (HP:0002136)2.41430814
59Anteriorly placed anus (HP:0001545)2.41289063
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.40287984
61Limb dystonia (HP:0002451)2.39453097
62Absent septum pellucidum (HP:0001331)2.38716539
63Epileptiform EEG discharges (HP:0011182)2.38092077
64Congenital primary aphakia (HP:0007707)2.38071643
65Leukodystrophy (HP:0002415)2.37923765
66Protruding tongue (HP:0010808)2.36324213
67Gaze-evoked nystagmus (HP:0000640)2.31190567
68Neuroendocrine neoplasm (HP:0100634)2.29705265
69Congenital ichthyosiform erythroderma (HP:0007431)2.28294143
70Status epilepticus (HP:0002133)2.27612749
71Poor eye contact (HP:0000817)2.26590259
72Progressive cerebellar ataxia (HP:0002073)2.25626947
73Partial agenesis of the corpus callosum (HP:0001338)2.24554379
74Decreased lacrimation (HP:0000633)2.24022124
75Action tremor (HP:0002345)2.17841138
76Hypoplastic pelvis (HP:0008839)2.17786508
77Abnormal eating behavior (HP:0100738)2.17164366
78Nephrogenic diabetes insipidus (HP:0009806)2.16750387
79Agitation (HP:0000713)2.16400508
80Congenital stationary night blindness (HP:0007642)2.15957773
81Increased circulating renin level (HP:0000848)2.14934872
82Generalized myoclonic seizures (HP:0002123)2.14369856
83Aplasia involving bones of the upper limbs (HP:0009823)2.14340444
84Aplasia of the phalanges of the hand (HP:0009802)2.14340444
85Aplasia involving bones of the extremities (HP:0009825)2.14340444
86Urinary bladder sphincter dysfunction (HP:0002839)2.13313122
87Dialeptic seizures (HP:0011146)2.12325384
88EEG with generalized epileptiform discharges (HP:0011198)2.11221469
89Chronic hepatic failure (HP:0100626)2.07915854
90Renal cortical cysts (HP:0000803)2.07605611
91Progressive inability to walk (HP:0002505)2.07258739
92Cerebral hemorrhage (HP:0001342)2.07225957
93Spastic paraparesis (HP:0002313)2.06892558
94Vaginal atresia (HP:0000148)2.05592242
95Abnormality of the renal cortex (HP:0011035)2.05343730
96Specific learning disability (HP:0001328)2.05122008
97Decreased circulating renin level (HP:0003351)2.03915247
98Abnormality of the septum pellucidum (HP:0007375)2.02772494
99Hypsarrhythmia (HP:0002521)2.02705843
100Urinary urgency (HP:0000012)2.02454490
101Dysdiadochokinesis (HP:0002075)2.02446357
102Short tibia (HP:0005736)2.01181230
103Genital tract atresia (HP:0001827)2.00137855
104Decreased central vision (HP:0007663)1.99476820
105Impaired smooth pursuit (HP:0007772)1.98782184
106Split foot (HP:0001839)1.96986900
107Widely spaced teeth (HP:0000687)1.95632315
108CNS hypomyelination (HP:0003429)1.95614768
109Cystic liver disease (HP:0006706)1.95085706
110Metabolic alkalosis (HP:0200114)1.94548841
111Megalencephaly (HP:0001355)1.93851971
112Humeroradial synostosis (HP:0003041)1.93705119
113Synostosis involving the elbow (HP:0003938)1.93705119
114Methylmalonic acidemia (HP:0002912)1.92392381
115Tented upper lip vermilion (HP:0010804)1.91588972
116Poor speech (HP:0002465)1.91299914
117Poor coordination (HP:0002370)1.91187866
118Cupped ear (HP:0000378)1.90926580
119Premature skin wrinkling (HP:0100678)1.90079213
120Absence seizures (HP:0002121)1.90070848
121Morphological abnormality of the pyramidal tract (HP:0002062)1.90056014
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88532918
123Hepatoblastoma (HP:0002884)1.88493318
124Spastic tetraplegia (HP:0002510)1.88389676
125Stridor (HP:0010307)1.87960967
126Type II lissencephaly (HP:0007260)1.87437092
127Infantile muscular hypotonia (HP:0008947)1.85891257
128Morphological abnormality of the inner ear (HP:0011390)1.84772953
129Septo-optic dysplasia (HP:0100842)1.84404849
130Clonus (HP:0002169)1.84164310
131Amyotrophic lateral sclerosis (HP:0007354)1.83946050
132Hypomagnesemia (HP:0002917)1.83859626
133Syncope (HP:0001279)1.83305219
134Absent speech (HP:0001344)1.82979763
135Coronal craniosynostosis (HP:0004440)1.82505864
136Abnormal social behavior (HP:0012433)1.81529316
137Impaired social interactions (HP:0000735)1.81529316
138Gait imbalance (HP:0002141)1.80625958
139Postural instability (HP:0002172)1.80504656
140Absent/shortened dynein arms (HP:0200106)1.80320772
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.80320772
142Diminished movement (HP:0002374)1.80029209
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79698568
144Decreased motor nerve conduction velocity (HP:0003431)1.79556790
145Relative macrocephaly (HP:0004482)1.79441547
146Bowel incontinence (HP:0002607)1.78646544
147Visual hallucinations (HP:0002367)1.78373229
148Truncal ataxia (HP:0002078)1.78301968
149Spastic tetraparesis (HP:0001285)1.77413677
150Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77034810
151Urinary incontinence (HP:0000020)1.76394643
152Postaxial hand polydactyly (HP:0001162)1.75242145
153Pachygyria (HP:0001302)1.74599809
154Hammertoe (HP:0001765)1.74102140
155Myelomeningocele (HP:0002475)1.73555055
156Cutaneous finger syndactyly (HP:0010554)1.73379857
157Generalized tonic-clonic seizures (HP:0002069)1.72979633
158Abnormality of the labia minora (HP:0012880)1.72899078
159Abnormality of ocular smooth pursuit (HP:0000617)1.72231781
160Segmental peripheral demyelination/remyelination (HP:0003481)1.72088493
161Lissencephaly (HP:0001339)1.70977240
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.70506058
163Impaired vibratory sensation (HP:0002495)1.70021455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.44148101
2OXSR14.41038282
3FRK3.39306790
4CDK192.96847736
5TNIK2.83775667
6CASK2.75680470
7PRPF4B2.66582598
8EPHB12.54314384
9BCR2.52861510
10EPHA42.30919076
11MAP4K22.19838656
12PKN12.15690018
13WNK42.10763579
14PNCK2.05037895
15PINK11.96452865
16PBK1.96423352
17MAPKAPK51.88623451
18MARK11.82233811
19WNK11.81143458
20MET1.74415818
21FGFR21.72280041
22NEK61.70993345
23PAK61.68812971
24NTRK11.58921895
25UHMK11.56809647
26CSNK1G31.52787707
27EPHA31.51259474
28CAMK2B1.49191728
29FGR1.43356397
30ICK1.42876145
31CSNK1A1L1.41565452
32LIMK11.41534005
33SGK21.38414623
34CAMKK21.33800147
35ROCK21.33512614
36CCNB11.31414290
37NTRK31.28725620
38CSNK1G21.28281988
39SGK2231.23820828
40SGK4941.23820828
41GRK11.22351097
42CAMK2D1.19107754
43MAP3K41.18510071
44CSNK1G11.17428462
45SIK21.14462989
46CAMK2A1.04932966
47CLK11.04499705
48CDK51.03533816
49MAP2K70.99688672
50MAPK130.98770035
51PAK30.97004433
52NTRK20.96412422
53NUAK10.93954574
54CDK140.93559209
55TYRO30.93425968
56BMPR1B0.90552180
57MARK20.89817233
58CAMK2G0.89134259
59CAMK10.88494364
60DYRK20.87322221
61CDK150.86315179
62MST40.85470531
63CDK180.83768422
64MUSK0.80951686
65PHKG10.80119211
66PHKG20.80119211
67CDK11A0.76394887
68ERBB30.76041328
69INSRR0.75173515
70PRKCE0.75069646
71TESK20.73631670
72PRKCQ0.73624840
73SGK30.72632539
74TAOK30.70437619
75CAMK40.69904757
76ACVR1B0.68668842
77CAMKK10.68091447
78MAP3K90.67104021
79AKT30.67072842
80ERBB40.65839147
81PRKCZ0.65821337
82MKNK20.65257567
83ARAF0.64317349
84PLK20.64066609
85MINK10.62724373
86PRKD30.59092608
87MAP3K130.58819516
88PDPK10.58467024
89ADRBK10.57061656
90RPS6KA30.56579497
91STK110.55274668
92TRIM280.53654639
93FYN0.53638128
94DAPK20.52948929
95PRKG10.52671848
96CAMK1G0.52128326
97FES0.52099403
98DMPK0.52046331
99DYRK1A0.50213519
100MAPK150.49687108
101GRK70.47287425
102IRAK20.46893197
103KSR20.46419233
104ERBB20.45939987
105PRKD10.45812506
106PRKCG0.45715121
107ADRBK20.44990479
108CSNK1D0.43379561
109GRK50.43063050
110CSNK1A10.43060191
111MAPK40.42921299
112MAPK70.42182532
113CDK30.41951439
114BRD40.41670991
115TLK10.41574236
116PRKCA0.40959246
117PIK3CA0.40925473
118MAPK120.40685683
119BMPR20.40005460
120PRKACB0.39333814
121PTK2B0.39037935
122NME10.38911294
123PRKCH0.38885695
124DYRK30.38078977
125WNK30.37346889
126PRKCB0.37157829
127ZAK0.36519298
128SGK10.35700539
129PRKACA0.33973645
130PRKAA10.33399112
131GSK3B0.33367367
132MAPK100.30979899
133RPS6KA50.29437295
134PDK10.28845786
135CSNK1E0.28181364
136TRPM70.27944945
137MAP2K40.27937355

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.48583405
2Steroid biosynthesis_Homo sapiens_hsa001003.91308535
3Fatty acid elongation_Homo sapiens_hsa000623.44944092
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17077119
5Ether lipid metabolism_Homo sapiens_hsa005652.62193185
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60926659
7Nicotine addiction_Homo sapiens_hsa050332.43646138
8GABAergic synapse_Homo sapiens_hsa047272.07064575
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03992638
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99768175
11Glutamatergic synapse_Homo sapiens_hsa047241.97534035
12Axon guidance_Homo sapiens_hsa043601.94833892
13Oxidative phosphorylation_Homo sapiens_hsa001901.90334896
14Morphine addiction_Homo sapiens_hsa050321.89043549
15Serotonergic synapse_Homo sapiens_hsa047261.79424412
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69569706
17Sphingolipid metabolism_Homo sapiens_hsa006001.67777531
18Synaptic vesicle cycle_Homo sapiens_hsa047211.67643584
19Collecting duct acid secretion_Homo sapiens_hsa049661.56927154
20Circadian entrainment_Homo sapiens_hsa047131.51778765
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45414035
22Long-term depression_Homo sapiens_hsa047301.43189884
23Alzheimers disease_Homo sapiens_hsa050101.33061070
24Salivary secretion_Homo sapiens_hsa049701.28518551
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24757313
26Taste transduction_Homo sapiens_hsa047421.23600494
27Parkinsons disease_Homo sapiens_hsa050121.23056670
28Vibrio cholerae infection_Homo sapiens_hsa051101.22562273
29Sulfur metabolism_Homo sapiens_hsa009201.22107283
30Dopaminergic synapse_Homo sapiens_hsa047281.20593333
31Butanoate metabolism_Homo sapiens_hsa006501.20546344
32Linoleic acid metabolism_Homo sapiens_hsa005911.17125246
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16876397
34Protein export_Homo sapiens_hsa030601.14841035
35Cocaine addiction_Homo sapiens_hsa050301.13487626
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13171292
37Amphetamine addiction_Homo sapiens_hsa050311.07616472
38Vitamin B6 metabolism_Homo sapiens_hsa007501.07237509
39Olfactory transduction_Homo sapiens_hsa047401.05005781
40Phototransduction_Homo sapiens_hsa047441.04705075
41Cholinergic synapse_Homo sapiens_hsa047251.02950404
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99719962
43Cardiac muscle contraction_Homo sapiens_hsa042600.99091563
44Renin secretion_Homo sapiens_hsa049240.98484130
45Nitrogen metabolism_Homo sapiens_hsa009100.97368308
46Long-term potentiation_Homo sapiens_hsa047200.96131626
47Gastric acid secretion_Homo sapiens_hsa049710.96065403
48Histidine metabolism_Homo sapiens_hsa003400.95799042
49Renal cell carcinoma_Homo sapiens_hsa052110.94810577
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88629113
51Circadian rhythm_Homo sapiens_hsa047100.85149559
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.85099620
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.84509707
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84167104
55ErbB signaling pathway_Homo sapiens_hsa040120.83472256
56Type II diabetes mellitus_Homo sapiens_hsa049300.82685374
57Rheumatoid arthritis_Homo sapiens_hsa053230.82017679
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79703903
59Bile secretion_Homo sapiens_hsa049760.78871049
60Insulin secretion_Homo sapiens_hsa049110.77916981
61Calcium signaling pathway_Homo sapiens_hsa040200.77487889
62Ras signaling pathway_Homo sapiens_hsa040140.76053023
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74906355
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.73471532
65Gap junction_Homo sapiens_hsa045400.73020661
66Tight junction_Homo sapiens_hsa045300.72847015
67Ovarian steroidogenesis_Homo sapiens_hsa049130.72069245
68cAMP signaling pathway_Homo sapiens_hsa040240.69833966
69Dorso-ventral axis formation_Homo sapiens_hsa043200.69777694
70Estrogen signaling pathway_Homo sapiens_hsa049150.69413477
71Arginine and proline metabolism_Homo sapiens_hsa003300.68678854
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68387561
73Pancreatic secretion_Homo sapiens_hsa049720.67478076
74Oxytocin signaling pathway_Homo sapiens_hsa049210.67377362
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67193504
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.66328223
77ABC transporters_Homo sapiens_hsa020100.66154053
78beta-Alanine metabolism_Homo sapiens_hsa004100.65931353
79Thyroid hormone synthesis_Homo sapiens_hsa049180.64137510
80Huntingtons disease_Homo sapiens_hsa050160.63911090
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63220344
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59831922
83Endocytosis_Homo sapiens_hsa041440.58934646
84Tryptophan metabolism_Homo sapiens_hsa003800.58586285
85Rap1 signaling pathway_Homo sapiens_hsa040150.57894341
86Autoimmune thyroid disease_Homo sapiens_hsa053200.56764411
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56638306
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55524972
89Glycerolipid metabolism_Homo sapiens_hsa005610.53552003
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.50100607
91Hedgehog signaling pathway_Homo sapiens_hsa043400.49545686
92Choline metabolism in cancer_Homo sapiens_hsa052310.49242027
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49105079
94Fatty acid biosynthesis_Homo sapiens_hsa000610.49067620
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49052883
96Fatty acid metabolism_Homo sapiens_hsa012120.48623196
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48155666
98Phagosome_Homo sapiens_hsa041450.48119193
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47531166
100Arachidonic acid metabolism_Homo sapiens_hsa005900.46769642
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46514089
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46387162
103GnRH signaling pathway_Homo sapiens_hsa049120.45719688
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44802543
105Propanoate metabolism_Homo sapiens_hsa006400.44181496
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44082312
107MAPK signaling pathway_Homo sapiens_hsa040100.44046163
108Oocyte meiosis_Homo sapiens_hsa041140.43565310
109Mineral absorption_Homo sapiens_hsa049780.43187054
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.43007213
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42366261
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41677517
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40783008
114Peroxisome_Homo sapiens_hsa041460.40748609
115Regulation of autophagy_Homo sapiens_hsa041400.40553932
116Melanogenesis_Homo sapiens_hsa049160.39719974
117Hippo signaling pathway_Homo sapiens_hsa043900.39239817
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36287960
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36022601
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35905842
121Lysosome_Homo sapiens_hsa041420.35025717
122Wnt signaling pathway_Homo sapiens_hsa043100.34897611
123Retinol metabolism_Homo sapiens_hsa008300.34839342
124Dilated cardiomyopathy_Homo sapiens_hsa054140.34791602
125Alcoholism_Homo sapiens_hsa050340.34301579
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.32707506
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32539144
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32302425
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31099333

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