ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.54191435
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.14020745
3	presynaptic membrane organization (GO:0097090)	3.90249964
4	presynaptic membrane assembly (GO:0097105)	3.87825582
5	nucleobase catabolic process (GO:0046113)	3.64033001
6	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.36853725
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31173831
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.29027200
9	nonmotile primary cilium assembly (GO:0035058)	3.23914515
10	response to pheromone (GO:0019236)	3.20422615
11	epithelial cilium movement (GO:0003351)	3.20176970
12	neuron cell-cell adhesion (GO:0007158)	3.20161417
13	gamma-aminobutyric acid transport (GO:0015812)	3.08045824
14	postsynaptic membrane organization (GO:0001941)	3.07386695
15	reflex (GO:0060004)	3.02213185
16	protein localization to cilium (GO:0061512)	3.00900638
17	startle response (GO:0001964)	2.98224674
18	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.98185739
19	retinal ganglion cell axon guidance (GO:0031290)	2.98070848
20	L-fucose catabolic process (GO:0042355)	2.97072205
21	fucose catabolic process (GO:0019317)	2.97072205
22	L-fucose metabolic process (GO:0042354)	2.97072205
23	water-soluble vitamin biosynthetic process (GO:0042364)	2.92477435
24	transmission of nerve impulse (GO:0019226)	2.86995906
25	cellular ketone body metabolic process (GO:0046950)	2.85239181
26	intraciliary transport (GO:0042073)	2.84134777
27	kidney morphogenesis (GO:0060993)	2.81356286
28	cilium morphogenesis (GO:0060271)	2.79165919
29	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.79053320
30	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.78206009
31	auditory behavior (GO:0031223)	2.77351313
32	behavioral response to ethanol (GO:0048149)	2.76693418
33	protein localization to synapse (GO:0035418)	2.76647803
34	detection of light stimulus involved in sensory perception (GO:0050962)	2.76343478
35	detection of light stimulus involved in visual perception (GO:0050908)	2.76343478
36	proline transport (GO:0015824)	2.75863149
37	synapse assembly (GO:0007416)	2.75616133
38	axonal fasciculation (GO:0007413)	2.75395721
39	cilium movement (GO:0003341)	2.73990354
40	cilium organization (GO:0044782)	2.73824896
41	cilium assembly (GO:0042384)	2.71172115
42	dendritic spine morphogenesis (GO:0060997)	2.67559042
43	neuronal action potential propagation (GO:0019227)	2.66932769
44	mechanosensory behavior (GO:0007638)	2.65700476
45	neural tube formation (GO:0001841)	2.65176312
46	nephron epithelium morphogenesis (GO:0072088)	2.62145817
47	nephron tubule morphogenesis (GO:0072078)	2.62145817
48	neuron recognition (GO:0008038)	2.61995803
49	adult feeding behavior (GO:0008343)	2.61856503
50	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.60620705
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.60620705
52	regulation of translation, ncRNA-mediated (GO:0045974)	2.60620705
53	cornea development in camera-type eye (GO:0061303)	2.59656184
54	somite rostral/caudal axis specification (GO:0032525)	2.59122411
55	indolalkylamine metabolic process (GO:0006586)	2.59062629
56	neuronal action potential (GO:0019228)	2.58653858
57	photoreceptor cell development (GO:0042461)	2.58310534
58	glutamate receptor signaling pathway (GO:0007215)	2.58284679
59	protein polyglutamylation (GO:0018095)	2.54358815
60	protein complex biogenesis (GO:0070271)	2.54137763
61	ketone body metabolic process (GO:1902224)	2.53460418
62	vocalization behavior (GO:0071625)	2.51688211
63	regulation of action potential (GO:0098900)	2.47465082
64	limb bud formation (GO:0060174)	2.47026001
65	axoneme assembly (GO:0035082)	2.46618138
66	respiratory chain complex IV assembly (GO:0008535)	2.44475098
67	regulation of glucokinase activity (GO:0033131)	2.44104578
68	regulation of hexokinase activity (GO:1903299)	2.44104578
69	neuron fate determination (GO:0048664)	2.44063769
70	platelet dense granule organization (GO:0060155)	2.43358684
71	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.43227911
72	synaptic transmission, glutamatergic (GO:0035249)	2.42367616
73	regulation of neurotransmitter uptake (GO:0051580)	2.41506891
74	cochlea development (GO:0090102)	2.40885286
75	inner ear receptor stereocilium organization (GO:0060122)	2.38596610
76	hindbrain development (GO:0030902)	2.38398533
77	somite development (GO:0061053)	2.37196921
78	positive regulation of gastrulation (GO:2000543)	2.37184006
79	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.36170105
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.36141839
81	photoreceptor cell maintenance (GO:0045494)	2.35640157
82	regulation of collateral sprouting (GO:0048670)	2.34535026
83	forebrain neuron differentiation (GO:0021879)	2.33984705
84	regulation of feeding behavior (GO:0060259)	2.33197009
85	spinal cord motor neuron differentiation (GO:0021522)	2.32690592
86	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.32669809
87	behavioral defense response (GO:0002209)	2.32206607
88	behavioral fear response (GO:0001662)	2.32206607
89	serotonin metabolic process (GO:0042428)	2.32116610
90	renal tubule morphogenesis (GO:0061333)	2.31898317
91	regulation of cilium movement (GO:0003352)	2.31320989
92	negative regulation of telomere maintenance (GO:0032205)	2.29314991
93	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.29004467
94	C4-dicarboxylate transport (GO:0015740)	2.28516201
95	neuron-neuron synaptic transmission (GO:0007270)	2.28510478
96	eye photoreceptor cell development (GO:0042462)	2.28406233
97	inner ear receptor cell development (GO:0060119)	2.28280566
98	inositol phosphate catabolic process (GO:0071545)	2.27433962
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.27280430
100	NADH dehydrogenase complex assembly (GO:0010257)	2.27280430

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.65601383
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.33483437
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.26357306
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.90224222
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75604227
6	VDR_22108803_ChIP-Seq_LS180_Human	2.72871339
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.58036981
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56308393
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50714903
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.39923998
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34322926
12	FUS_26573619_Chip-Seq_HEK293_Human	2.28732671
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21396433
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.21173635
15	P300_19829295_ChIP-Seq_ESCs_Human	2.20224133
16	EWS_26573619_Chip-Seq_HEK293_Human	2.12103891
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.04386143
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.02775997
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01169581
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95084721
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74510110
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71943683
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70886887
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68057722
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67321574
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.66827688
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65344591
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64571889
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64308179
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63915696
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62646901
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.58150586
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.57256253
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56513916
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54657139
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53763221
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53341398
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53341398
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52556362
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50286690
41	STAT3_23295773_ChIP-Seq_U87_Human	1.49867840
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49329307
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48379310
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45476160
45	AR_25329375_ChIP-Seq_VCAP_Human	1.41098013
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40711456
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.39628635
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39628635
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39338391
50	TCF4_23295773_ChIP-Seq_U87_Human	1.36532902
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.36208235
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35953105
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.35530658
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33537745
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29473747
56	* JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29396071
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28657078
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28579334
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27971009
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27159181
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25986396
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.24152187
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.23951356
64	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.23261195
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22380416
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.22304436
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.21075465
68	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.20839803
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20394715
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20116081
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18535369
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17804256
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17067983
74	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.16170998
75	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.16170998
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15228604
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13202736
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12805791
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12358837
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.12327005
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09833923
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09290588
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08569078
84	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08362729
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05650051
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04940699
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04064206
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03078327
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02914047
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02914047
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02345432
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01318528
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00954880
94	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.00888877
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00233116
96	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99979770
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99775500
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97399400
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96873585
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95525342

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.99589562
2	MP0003787_abnormal_imprinting	2.64123905
3	MP0008877_abnormal_DNA_methylation	2.62542224
4	MP0006292_abnormal_olfactory_placode	2.17627998
5	MP0004133_heterotaxia	2.16775083
6	MP0002102_abnormal_ear_morphology	2.16444555
7	MP0006276_abnormal_autonomic_nervous	2.16101446
8	MP0009046_muscle_twitch	2.13894626
9	MP0006072_abnormal_retinal_apoptosis	2.07809648
10	MP0005551_abnormal_eye_electrophysiolog	2.03262079
11	MP0001529_abnormal_vocalization	2.02496624
12	MP0000569_abnormal_digit_pigmentation	2.00811011
13	MP0001968_abnormal_touch/_nociception	1.98566120
14	MP0003136_yellow_coat_color	1.97799549
15	MP0009745_abnormal_behavioral_response	1.92518160
16	MP0000778_abnormal_nervous_system	1.90777075
17	MP0003195_calcinosis	1.85949748
18	MP0003122_maternal_imprinting	1.85861668
19	MP0001984_abnormal_olfaction	1.83622786
20	MP0002638_abnormal_pupillary_reflex	1.80748511
21	MP0004885_abnormal_endolymph	1.80596352
22	MP0000631_abnormal_neuroendocrine_gland	1.79474974
23	MP0002272_abnormal_nervous_system	1.78750162
24	MP0005645_abnormal_hypothalamus_physiol	1.77213447
25	MP0003890_abnormal_embryonic-extraembry	1.75761642
26	MP0002736_abnormal_nociception_after	1.74641465
27	MP0001486_abnormal_startle_reflex	1.71303980
28	MP0005253_abnormal_eye_physiology	1.69353303
29	MP0002938_white_spotting	1.69332336
30	MP0005423_abnormal_somatic_nervous	1.68929967
31	MP0004142_abnormal_muscle_tone	1.67799695
32	MP0002837_dystrophic_cardiac_calcinosis	1.66205408
33	MP0005646_abnormal_pituitary_gland	1.62473262
34	MP0002572_abnormal_emotion/affect_behav	1.61790249
35	MP0002653_abnormal_ependyma_morphology	1.61044369
36	MP0003121_genomic_imprinting	1.60612490
37	MP0003635_abnormal_synaptic_transmissio	1.59513226
38	MP0002822_catalepsy	1.55395526
39	MP0002064_seizures	1.53069042
40	MP0002735_abnormal_chemical_nociception	1.53006370
41	MP0004270_analgesia	1.52725179
42	MP0002557_abnormal_social/conspecific_i	1.51797496
43	MP0001485_abnormal_pinna_reflex	1.48951312
44	MP0002909_abnormal_adrenal_gland	1.47955435
45	MP0003011_delayed_dark_adaptation	1.45835689
46	MP0002063_abnormal_learning/memory/cond	1.39793185
47	MP0004859_abnormal_synaptic_plasticity	1.38433940
48	MP0008872_abnormal_physiological_respon	1.38319561
49	MP0002734_abnormal_mechanical_nocicepti	1.38282597
50	MP0002184_abnormal_innervation	1.35527834
51	MP0001188_hyperpigmentation	1.35443738
52	MP0002067_abnormal_sensory_capabilities	1.29893998
53	MP0004742_abnormal_vestibular_system	1.27218327
54	MP0002876_abnormal_thyroid_physiology	1.26892552
55	MP0002928_abnormal_bile_duct	1.22572568
56	MP0004924_abnormal_behavior	1.21315114
57	MP0005386_behavior/neurological_phenoty	1.21315114
58	MP0001970_abnormal_pain_threshold	1.19764495
59	MP0002751_abnormal_autonomic_nervous	1.18229935
60	MP0001986_abnormal_taste_sensitivity	1.17639550
61	MP0002752_abnormal_somatic_nervous	1.15946513
62	MP0001501_abnormal_sleep_pattern	1.15857830
63	MP0008789_abnormal_olfactory_epithelium	1.15015791
64	MP0000427_abnormal_hair_cycle	1.14253257
65	MP0000566_synostosis	1.14040196
66	MP0003283_abnormal_digestive_organ	1.13329435
67	MP0001293_anophthalmia	1.12420236
68	MP0003119_abnormal_digestive_system	1.11923040
69	MP0003937_abnormal_limbs/digits/tail_de	1.11920417
70	MP0000372_irregular_coat_pigmentation	1.11632824
71	MP0002234_abnormal_pharynx_morphology	1.11558752
72	MP0000955_abnormal_spinal_cord	1.11492906
73	MP0002882_abnormal_neuron_morphology	1.06960566
74	MP0005195_abnormal_posterior_eye	1.05345269
75	MP0000049_abnormal_middle_ear	1.03858621
76	MP0001905_abnormal_dopamine_level	1.03442971
77	MP0002733_abnormal_thermal_nociception	1.03419778
78	MP0001502_abnormal_circadian_rhythm	1.03400764
79	MP0004043_abnormal_pH_regulation	1.03268644
80	MP0000026_abnormal_inner_ear	1.01240701
81	MP0005394_taste/olfaction_phenotype	1.00876723
82	MP0005499_abnormal_olfactory_system	1.00876723
83	MP0005379_endocrine/exocrine_gland_phen	0.95792497
84	MP0001440_abnormal_grooming_behavior	0.92757302
85	MP0004145_abnormal_muscle_electrophysio	0.91449626
86	MP0005174_abnormal_tail_pigmentation	0.91402961
87	MP0002160_abnormal_reproductive_system	0.90272025
88	MP0003938_abnormal_ear_development	0.90175026
89	MP0005084_abnormal_gallbladder_morpholo	0.90095948
90	MP0001963_abnormal_hearing_physiology	0.86564977
91	MP0005367_renal/urinary_system_phenotyp	0.86420977
92	MP0000516_abnormal_urinary_system	0.86420977
93	MP0005391_vision/eye_phenotype	0.86239968
94	MP0002233_abnormal_nose_morphology	0.85904698
95	MP0008995_early_reproductive_senescence	0.85447417
96	MP0002163_abnormal_gland_morphology	0.85165156
97	MP0002152_abnormal_brain_morphology	0.84750541
98	MP0010386_abnormal_urinary_bladder	0.84177999
99	MP0003137_abnormal_impulse_conducting	0.83605532
100	MP0002229_neurodegeneration	0.83263072

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.04181105
2	Abnormality of midbrain morphology (HP:0002418)	4.04181105
3	Pancreatic cysts (HP:0001737)	3.91234167
4	Nephronophthisis (HP:0000090)	3.83540039
5	Pancreatic fibrosis (HP:0100732)	3.81882298
6	True hermaphroditism (HP:0010459)	3.65284799
7	Medial flaring of the eyebrow (HP:0010747)	3.43746626
8	Abnormality of the renal medulla (HP:0100957)	3.24714750
9	Gait imbalance (HP:0002141)	3.00671715
10	Congenital stationary night blindness (HP:0007642)	2.96873091
11	Limb dystonia (HP:0002451)	2.85944407
12	Focal motor seizures (HP:0011153)	2.85901249
13	Congenital primary aphakia (HP:0007707)	2.83190057
14	Type II lissencephaly (HP:0007260)	2.82287608
15	Hyperventilation (HP:0002883)	2.81862665
16	Chronic hepatic failure (HP:0100626)	2.77505897
17	Genital tract atresia (HP:0001827)	2.72815626
18	Vaginal atresia (HP:0000148)	2.68314190
19	Abolished electroretinogram (ERG) (HP:0000550)	2.64645573
20	Abnormality of the renal cortex (HP:0011035)	2.59829378
21	Nephrogenic diabetes insipidus (HP:0009806)	2.57833239
22	Abnormality of the labia minora (HP:0012880)	2.57793037
23	Broad-based gait (HP:0002136)	2.55206008
24	Febrile seizures (HP:0002373)	2.52271820
25	Large for gestational age (HP:0001520)	2.50272685
26	Cystic liver disease (HP:0006706)	2.44019760
27	Progressive cerebellar ataxia (HP:0002073)	2.38817281
28	Sclerocornea (HP:0000647)	2.38098457
29	Colon cancer (HP:0003003)	2.36880373
30	Intestinal atresia (HP:0011100)	2.33417549
31	Hypothermia (HP:0002045)	2.30450113
32	Focal seizures (HP:0007359)	2.28323099
33	Pendular nystagmus (HP:0012043)	2.25121667
34	Agitation (HP:0000713)	2.21780642
35	Lissencephaly (HP:0001339)	2.19271318
36	Inability to walk (HP:0002540)	2.19127844
37	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18542971
38	Drooling (HP:0002307)	2.16415591
39	Renal cortical cysts (HP:0000803)	2.12973439
40	Attenuation of retinal blood vessels (HP:0007843)	2.12109885
41	Poor coordination (HP:0002370)	2.10516138
42	Retinal dysplasia (HP:0007973)	2.09543361
43	Anencephaly (HP:0002323)	2.07691017
44	Hemiparesis (HP:0001269)	2.06669599
45	Chorioretinal atrophy (HP:0000533)	2.05124686
46	Polydipsia (HP:0001959)	2.04400368
47	Abnormal drinking behavior (HP:0030082)	2.04400368
48	Gaze-evoked nystagmus (HP:0000640)	2.02306170
49	Cerebellar dysplasia (HP:0007033)	2.01395907
50	Methylmalonic acidemia (HP:0002912)	2.01062782
51	Tubular atrophy (HP:0000092)	1.97934896
52	Postaxial hand polydactyly (HP:0001162)	1.97581560
53	Optic nerve hypoplasia (HP:0000609)	1.96717971
54	Acute necrotizing encephalopathy (HP:0006965)	1.96396540
55	Dialeptic seizures (HP:0011146)	1.93935066
56	Male pseudohermaphroditism (HP:0000037)	1.92393218
57	Postaxial foot polydactyly (HP:0001830)	1.92173419
58	Polyphagia (HP:0002591)	1.92144899
59	Congenital hepatic fibrosis (HP:0002612)	1.92090447
60	Progressive macrocephaly (HP:0004481)	1.90662678
61	Epileptic encephalopathy (HP:0200134)	1.90621044
62	Narrow forehead (HP:0000341)	1.90172848
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89379781
64	Excessive salivation (HP:0003781)	1.89167600
65	Anophthalmia (HP:0000528)	1.88855846
66	Genetic anticipation (HP:0003743)	1.88415201
67	Lipid accumulation in hepatocytes (HP:0006561)	1.88257844
68	Oligodactyly (hands) (HP:0001180)	1.87637179
69	Mitochondrial inheritance (HP:0001427)	1.87616880
70	Increased CSF lactate (HP:0002490)	1.87302191
71	Protruding tongue (HP:0010808)	1.86758615
72	Increased hepatocellular lipid droplets (HP:0006565)	1.85355355
73	Septo-optic dysplasia (HP:0100842)	1.85005299
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84163758
75	Acute encephalopathy (HP:0006846)	1.84080637
76	Rib fusion (HP:0000902)	1.83742436
77	Abnormal biliary tract physiology (HP:0012439)	1.83495477
78	Bile duct proliferation (HP:0001408)	1.83495477
79	Decreased central vision (HP:0007663)	1.82352882
80	Pachygyria (HP:0001302)	1.80657452
81	Furrowed tongue (HP:0000221)	1.80068812
82	Abnormal pancreas size (HP:0012094)	1.79578827
83	Bony spicule pigmentary retinopathy (HP:0007737)	1.78867066
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.76985972
85	Hypomagnesemia (HP:0002917)	1.76695668
86	Abnormality of macular pigmentation (HP:0008002)	1.76496603
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76047613
88	Abnormal respiratory epithelium morphology (HP:0012253)	1.76047613
89	Polyuria (HP:0000103)	1.75449614
90	Absent speech (HP:0001344)	1.74744646
91	Preaxial hand polydactyly (HP:0001177)	1.74418002
92	Myokymia (HP:0002411)	1.73816388
93	Specific learning disability (HP:0001328)	1.73621279
94	Increased corneal curvature (HP:0100692)	1.73471770
95	Keratoconus (HP:0000563)	1.73471770
96	Congenital, generalized hypertrichosis (HP:0004540)	1.73206695
97	Neoplasm of the adrenal cortex (HP:0100641)	1.73093605
98	Renal hypoplasia (HP:0000089)	1.72877087
99	Bilateral microphthalmos (HP:0007633)	1.72752579
100	Bifid tongue (HP:0010297)	1.71255158

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.28353702
2	CASK	3.68263536
3	WNK3	3.09578622
4	MARK1	2.40206904
5	ADRBK2	2.36587749
6	TNIK	2.28422628
7	BMPR1B	2.27958340
8	NUAK1	2.24406522
9	MAP3K4	2.21438740
10	MAP4K2	2.17306609
11	ZAK	2.05066612
12	PINK1	1.94130100
13	GRK1	1.83750017
14	MKNK2	1.81058778
15	PNCK	1.79357734
16	MAPK13	1.78610511
17	WNK4	1.66246483
18	DYRK2	1.64768355
19	ACVR1B	1.62582075
20	MAP2K7	1.56027750
21	INSRR	1.54006091
22	NTRK3	1.52621922
23	FGFR2	1.47169188
24	TRIM28	1.47067139
25	PAK3	1.45592707
26	CSNK1G2	1.43885520
27	OXSR1	1.35565343
28	BCR	1.30592182
29	NTRK2	1.28312218
30	CSNK1G1	1.25847407
31	PRKCG	1.23333386
32	STK39	1.22834930
33	CSNK1G3	1.18245834
34	EPHA4	1.16456333
35	STK38L	1.15215310
36	TAF1	1.10094004
37	DAPK2	1.09629058
38	PRKCE	1.01809392
39	VRK1	1.00129536
40	TLK1	1.00044067
41	CSNK1A1L	0.98575603
42	MKNK1	0.97953297
43	MAP2K4	0.91680506
44	CAMKK2	0.91082287
45	TAOK3	0.89458176
46	MAPK15	0.80993921
47	MAP3K12	0.80281193
48	ERBB3	0.79543467
49	ADRBK1	0.76625213
50	DYRK3	0.75644569
51	PHKG2	0.75321654
52	PHKG1	0.75321654
53	MINK1	0.73962739
54	AKT3	0.73794027
55	CAMK2A	0.73440927
56	PLK2	0.71837382
57	PLK3	0.71189886
58	MST4	0.70542123
59	BCKDK	0.67360675
60	CDK19	0.67288124
61	PIK3CA	0.66870698
62	PASK	0.66841890
63	DYRK1A	0.63918545
64	TIE1	0.63657006
65	EPHA3	0.61242406
66	CAMK1	0.59564508
67	STK16	0.59448821
68	SRPK1	0.58461683
69	TGFBR1	0.58418552
70	STK11	0.58259944
71	NME1	0.55116170
72	EPHB2	0.54478798
73	PLK4	0.52790230
74	CAMK1G	0.51482580
75	PRKACA	0.51045764
76	NLK	0.50918321
77	LATS1	0.50446766
78	CSNK1A1	0.48763162
79	VRK2	0.48522922
80	CDK5	0.48365695
81	CSNK1D	0.46955422
82	TXK	0.46647161
83	TSSK6	0.46632653
84	CDK3	0.46405655
85	CAMK2D	0.45690076
86	CSNK1E	0.44110066
87	MUSK	0.43867349
88	UHMK1	0.42418066
89	PRKG1	0.41274658
90	SGK2	0.41078470
91	STK3	0.40918442
92	MAPKAPK5	0.40899978
93	ERBB2	0.40578552
94	OBSCN	0.40075167
95	SGK494	0.39780781
96	SGK223	0.39780781
97	PRKCZ	0.35782186
98	PRKACB	0.34738210
99	PKN1	0.34293290
100	MAP2K6	0.34124233

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.15184031
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.67583179
3	Phototransduction_Homo sapiens_hsa04744	2.63311039
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.60136473
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57707764
6	Protein export_Homo sapiens_hsa03060	2.52918530
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15365738
8	Butanoate metabolism_Homo sapiens_hsa00650	2.11660136
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04620141
10	Parkinsons disease_Homo sapiens_hsa05012	2.00154145
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95165114
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91293215
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.85986144
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76098746
15	Taste transduction_Homo sapiens_hsa04742	1.73283113
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.70972259
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69085986
18	GABAergic synapse_Homo sapiens_hsa04727	1.63931983
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62760040
20	Morphine addiction_Homo sapiens_hsa05032	1.59745948
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.56030359
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55504570
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54593933
24	Insulin secretion_Homo sapiens_hsa04911	1.54065522
25	Circadian entrainment_Homo sapiens_hsa04713	1.53703581
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52982388
27	Basal transcription factors_Homo sapiens_hsa03022	1.41872105
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.37845081
29	Huntingtons disease_Homo sapiens_hsa05016	1.35192912
30	Alzheimers disease_Homo sapiens_hsa05010	1.31883374
31	Serotonergic synapse_Homo sapiens_hsa04726	1.30501325
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28597343
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27210295
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27184499
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.27091810
36	RNA polymerase_Homo sapiens_hsa03020	1.25385519
37	Propanoate metabolism_Homo sapiens_hsa00640	1.20464960
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.20327083
39	RNA degradation_Homo sapiens_hsa03018	1.19862853
40	Olfactory transduction_Homo sapiens_hsa04740	1.15063908
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.14979639
42	Cocaine addiction_Homo sapiens_hsa05030	1.12029559
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.11288214
44	Amphetamine addiction_Homo sapiens_hsa05031	1.10378468
45	Caffeine metabolism_Homo sapiens_hsa00232	1.09795143
46	Peroxisome_Homo sapiens_hsa04146	1.08390222
47	Homologous recombination_Homo sapiens_hsa03440	1.06961090
48	Regulation of autophagy_Homo sapiens_hsa04140	1.05629445
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02152673
50	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00381871
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99708576
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.94357099
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90760136
54	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.89888391
55	Axon guidance_Homo sapiens_hsa04360	0.88886451
56	Circadian rhythm_Homo sapiens_hsa04710	0.86093177
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82406257
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79004243
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78795991
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78043417
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77886749
62	Retinol metabolism_Homo sapiens_hsa00830	0.76870551
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76294467
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.75311423
65	Long-term depression_Homo sapiens_hsa04730	0.73732600
66	Salivary secretion_Homo sapiens_hsa04970	0.72544729
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69852866
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68856758
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.68460551
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67826418
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.66726756
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.62855967
73	Cholinergic synapse_Homo sapiens_hsa04725	0.60409367
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.59435547
75	ABC transporters_Homo sapiens_hsa02010	0.59209969
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58712071
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58517383
78	Fatty acid elongation_Homo sapiens_hsa00062	0.57923070
79	Metabolic pathways_Homo sapiens_hsa01100	0.57824409
80	Purine metabolism_Homo sapiens_hsa00230	0.56933861
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.55838590
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52421051
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.51361305
84	Mineral absorption_Homo sapiens_hsa04978	0.50088724
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48787704
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47544588
87	One carbon pool by folate_Homo sapiens_hsa00670	0.47257987
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.43020430
89	Gastric acid secretion_Homo sapiens_hsa04971	0.42975592
90	Histidine metabolism_Homo sapiens_hsa00340	0.42549525
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42085260
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41757265
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41669402
94	Renin secretion_Homo sapiens_hsa04924	0.41196203
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40338224
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39591127
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39311844
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38607710
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.37928097
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35933464

PCDHA10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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