PCDHA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56684198
2neuron cell-cell adhesion (GO:0007158)5.35348218
3vocalization behavior (GO:0071625)5.33732044
4protein localization to synapse (GO:0035418)5.10300305
5synaptic vesicle exocytosis (GO:0016079)4.98806937
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87090384
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72664567
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68000332
9synaptic vesicle maturation (GO:0016188)4.61421471
10regulation of synaptic vesicle exocytosis (GO:2000300)4.58731912
11glutamate secretion (GO:0014047)4.51022077
12regulation of glutamate receptor signaling pathway (GO:1900449)4.27453835
13locomotory exploration behavior (GO:0035641)4.23700000
14exploration behavior (GO:0035640)4.16186445
15presynaptic membrane assembly (GO:0097105)4.13972419
16neuron recognition (GO:0008038)4.07977342
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07418221
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.02683984
19regulation of synaptic vesicle transport (GO:1902803)4.00331273
20neurotransmitter-gated ion channel clustering (GO:0072578)3.97557312
21glutamate receptor signaling pathway (GO:0007215)3.96119025
22layer formation in cerebral cortex (GO:0021819)3.92307453
23neuronal action potential propagation (GO:0019227)3.91541656
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.90668882
25neurotransmitter secretion (GO:0007269)3.90252891
26postsynaptic membrane organization (GO:0001941)3.89682466
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87652463
28proline transport (GO:0015824)3.84076152
29synaptic transmission, glutamatergic (GO:0035249)3.83919741
30neuron-neuron synaptic transmission (GO:0007270)3.80880350
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.75790624
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73595606
33dendritic spine morphogenesis (GO:0060997)3.73189293
34presynaptic membrane organization (GO:0097090)3.69677042
35positive regulation of synapse maturation (GO:0090129)3.68041895
36axonal fasciculation (GO:0007413)3.63297919
37calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.59155006
38regulation of neuronal synaptic plasticity (GO:0048168)3.55680302
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48984829
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.48874823
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48610366
42synapse assembly (GO:0007416)3.45383868
43pyrimidine nucleobase catabolic process (GO:0006208)3.43716582
44paraxial mesoderm development (GO:0048339)3.43659360
45regulation of synapse structural plasticity (GO:0051823)3.42647097
46regulation of postsynaptic membrane potential (GO:0060078)3.42109395
47transmission of nerve impulse (GO:0019226)3.42093519
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41824047
49dendrite morphogenesis (GO:0048813)3.38001884
50cell migration in hindbrain (GO:0021535)3.36101829
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.35596241
52neurotransmitter transport (GO:0006836)3.35595352
53positive regulation of membrane potential (GO:0045838)3.35594901
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32032174
55cerebellar Purkinje cell differentiation (GO:0021702)3.31584438
56gamma-aminobutyric acid transport (GO:0015812)3.30728820
57response to pheromone (GO:0019236)3.30227279
58innervation (GO:0060384)3.30161015
59startle response (GO:0001964)3.29366932
60response to histamine (GO:0034776)3.26790733
61regulation of neurotransmitter secretion (GO:0046928)3.26149686
62regulation of vesicle fusion (GO:0031338)3.24981619
63cardiac right ventricle morphogenesis (GO:0003215)3.21601403
64positive regulation of synapse assembly (GO:0051965)3.20256015
65synaptic vesicle endocytosis (GO:0048488)3.20233661
66behavioral defense response (GO:0002209)3.19472977
67behavioral fear response (GO:0001662)3.19472977
68long-term memory (GO:0007616)3.18071726
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14296723
70regulation of synapse maturation (GO:0090128)3.11210482
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09343277
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09231313
73cerebellar granule cell differentiation (GO:0021707)3.08372150
74fear response (GO:0042596)3.07001653
75cellular potassium ion homeostasis (GO:0030007)3.06037705
76long-term synaptic potentiation (GO:0060291)3.05323104
77regulation of dendritic spine morphogenesis (GO:0061001)3.05132806
78central nervous system projection neuron axonogenesis (GO:0021952)3.03647396
79synapse organization (GO:0050808)3.02589703
80nucleobase catabolic process (GO:0046113)3.02118492
81regulation of neurotransmitter levels (GO:0001505)3.00048599
82positive regulation of dendritic spine morphogenesis (GO:0061003)2.98337270
83activation of protein kinase A activity (GO:0034199)2.97234618
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95701789
85membrane hyperpolarization (GO:0060081)2.95301087
86regulation of neurotransmitter transport (GO:0051588)2.95095900
87regulation of synaptic plasticity (GO:0048167)2.94888449
88learning (GO:0007612)2.94533893
89membrane depolarization (GO:0051899)2.94458910
90membrane depolarization during action potential (GO:0086010)2.93597625
91detection of calcium ion (GO:0005513)2.93441692
92organelle transport along microtubule (GO:0072384)2.92125749
93negative regulation of microtubule polymerization (GO:0031115)2.91408725
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91400328
95response to auditory stimulus (GO:0010996)2.89187737
96synaptic transmission (GO:0007268)2.88195589
97auditory behavior (GO:0031223)2.87656826
98positive regulation of potassium ion transmembrane transport (GO:1901381)2.85839377
99neuromuscular process controlling posture (GO:0050884)2.85812913
100mating behavior (GO:0007617)2.84067361
101ganglion development (GO:0061548)2.79301597
102regulation of synaptic transmission, GABAergic (GO:0032228)2.79209032
103establishment of mitochondrion localization (GO:0051654)2.77944149
104calcium ion-dependent exocytosis (GO:0017156)2.76515192
105adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70747372
106axon extension involved in axon guidance (GO:0048846)2.58655244
107neuron projection extension involved in neuron projection guidance (GO:1902284)2.58655244
108establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56856876
109mitochondrion transport along microtubule (GO:0047497)2.56856876
110suckling behavior (GO:0001967)2.55261800
111nonmotile primary cilium assembly (GO:0035058)2.54048604
112* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.51260928
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51143048
114cholesterol biosynthetic process (GO:0006695)2.46735767
115regulation of growth hormone secretion (GO:0060123)2.44878424
116limb bud formation (GO:0060174)2.44140936
117mechanosensory behavior (GO:0007638)2.43754089
118cochlea development (GO:0090102)2.42988276
119peptidyl-cysteine modification (GO:0018198)2.42654273
120neuronal stem cell maintenance (GO:0097150)2.40574039
121retinal ganglion cell axon guidance (GO:0031290)2.39676020
122C4-dicarboxylate transport (GO:0015740)2.38350975
123L-serine metabolic process (GO:0006563)2.36734183
124regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.36596980
125inner ear receptor cell development (GO:0060119)2.31873643
126ectodermal placode formation (GO:0060788)2.29149490
127cerebral cortex radially oriented cell migration (GO:0021799)2.28818700
128regulation of development, heterochronic (GO:0040034)2.28437464
129ephrin receptor signaling pathway (GO:0048013)2.27952085
130protein localization to cilium (GO:0061512)2.27599094
131DNA damage response, detection of DNA damage (GO:0042769)2.26875385
132cardiac ventricle morphogenesis (GO:0003208)2.24854111
133dendrite development (GO:0016358)2.24673360
134cell fate commitment involved in formation of primary germ layer (GO:0060795)2.22743668
135establishment of melanosome localization (GO:0032401)2.22404950
136neuron migration (GO:0001764)2.21176694
137negative regulation of axon guidance (GO:1902668)2.21032578
138apical protein localization (GO:0045176)2.19951688
139axon extension (GO:0048675)2.19269205
140hippocampus development (GO:0021766)2.18020729
141melanosome transport (GO:0032402)2.17687674
142axon cargo transport (GO:0008088)2.17575939
143sterol biosynthetic process (GO:0016126)2.16913704
144spinal cord development (GO:0021510)2.16745227
145establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.14679553
146sympathetic nervous system development (GO:0048485)2.14077492
147establishment of integrated proviral latency (GO:0075713)2.13732722
148neuronal ion channel clustering (GO:0045161)2.12081755
149* cell-cell adhesion (GO:0098609)2.11558126
150amino acid import (GO:0043090)2.11359687
151positive regulation of mitochondrial fission (GO:0090141)2.11298249
152* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.11178226
153melanosome localization (GO:0032400)2.10863248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34121647
2GBX2_23144817_ChIP-Seq_PC3_Human4.20713992
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.61882066
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08483568
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93899821
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87534354
7REST_21632747_ChIP-Seq_MESCs_Mouse2.71966916
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.59508092
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56724926
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54414372
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54414372
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52470652
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51482254
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.49026944
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42107640
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41013091
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36745323
18TAF15_26573619_Chip-Seq_HEK293_Human2.33333362
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29245868
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.28940979
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.23769916
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23309809
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14465181
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14274650
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.13506398
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11494099
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.08065071
28DROSHA_22980978_ChIP-Seq_HELA_Human2.07961357
29AR_21572438_ChIP-Seq_LNCaP_Human2.04786675
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03096613
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94389087
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.93377480
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92385451
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85944521
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85506872
36SMAD4_21799915_ChIP-Seq_A2780_Human1.79837812
37P300_19829295_ChIP-Seq_ESCs_Human1.77342166
38IGF1R_20145208_ChIP-Seq_DFB_Human1.75269575
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74152295
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67057526
41ZNF274_21170338_ChIP-Seq_K562_Hela1.66023832
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65504180
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64636278
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63282691
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.62782342
46EWS_26573619_Chip-Seq_HEK293_Human1.57786313
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.56530911
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55316097
49* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52717694
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51511739
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51087259
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.49247866
53RNF2_27304074_Chip-Seq_NSC_Mouse1.47874017
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.47842347
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46358977
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43901987
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43178307
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43020456
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42151128
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41949554
61FUS_26573619_Chip-Seq_HEK293_Human1.41038887
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.37734072
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.37501189
64AR_25329375_ChIP-Seq_VCAP_Human1.34762948
65VDR_22108803_ChIP-Seq_LS180_Human1.34611470
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32761845
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32606242
68STAT3_23295773_ChIP-Seq_U87_Human1.31550439
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26407232
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23812124
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23522412
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.23440345
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23183075
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22436745
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22290628
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.21945312
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20812438
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20745897
79SOX9_26525672_Chip-Seq_HEART_Mouse1.19825303
80ER_23166858_ChIP-Seq_MCF-7_Human1.18861007
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18594639
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17833960
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17798570
84* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17518850
85TCF4_23295773_ChIP-Seq_U87_Human1.17155466
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16094284
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15673814
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15216336
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13918634
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13481870
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.12638439
92JUN_21703547_ChIP-Seq_K562_Human1.11762196
93RUNX2_22187159_ChIP-Seq_PCA_Human1.11384537
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11273178
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10630736
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10118350
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10086342
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09881984
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.09077767
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.09049135
101AR_19668381_ChIP-Seq_PC3_Human1.08803963
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.06253433
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05722310
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05722310
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.05580945
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05549848
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.05163691
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04556160
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04211128
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04144714
111AHR_22903824_ChIP-Seq_MCF-7_Human1.04104264
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03490750
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03268210
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03267583
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.03117263
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01753183
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.99900323
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98347538
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97323038
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97065128
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96927968
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96381445
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.95775131
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95165149
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.94454632
126IRF1_19129219_ChIP-ChIP_H3396_Human0.94368756
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93041255
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92959999
129POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.92376090
130ELK1_19687146_ChIP-ChIP_HELA_Human0.92306880
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92098400
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90897534
133TP53_18474530_ChIP-ChIP_U2OS_Human0.90853146
134KDM2B_26808549_Chip-Seq_REH_Human0.90636665
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.89997694
136CBP_20019798_ChIP-Seq_JUKART_Human0.88975039
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88975039
138BCAT_22108803_ChIP-Seq_LS180_Human0.88493856
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85676397
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84720661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.10231506
2MP0003880_abnormal_central_pattern4.53875712
3MP0003635_abnormal_synaptic_transmissio3.71141474
4MP0004270_analgesia3.67652133
5MP0009745_abnormal_behavioral_response3.24859668
6MP0002063_abnormal_learning/memory/cond3.07871163
7MP0001968_abnormal_touch/_nociception2.98386486
8MP0002064_seizures2.91593248
9MP0009046_muscle_twitch2.87991731
10MP0002735_abnormal_chemical_nociception2.86764957
11MP0002822_catalepsy2.82357413
12MP0002734_abnormal_mechanical_nocicepti2.82330597
13MP0002572_abnormal_emotion/affect_behav2.72103964
14MP0005423_abnormal_somatic_nervous2.61822724
15MP0006276_abnormal_autonomic_nervous2.52602818
16MP0002736_abnormal_nociception_after2.47113460
17MP0002272_abnormal_nervous_system2.45217169
18MP0001486_abnormal_startle_reflex2.35022632
19MP0001440_abnormal_grooming_behavior2.34172907
20MP0002733_abnormal_thermal_nociception2.30457839
21MP0000778_abnormal_nervous_system2.22292125
22MP0001501_abnormal_sleep_pattern2.17948159
23MP0002184_abnormal_innervation2.15981450
24MP0002067_abnormal_sensory_capabilities2.12140185
25MP0001529_abnormal_vocalization2.10382170
26MP0002653_abnormal_ependyma_morphology2.09850234
27MP0001970_abnormal_pain_threshold2.07730230
28MP0004858_abnormal_nervous_system1.96928232
29MP0004924_abnormal_behavior1.93601231
30MP0005386_behavior/neurological_phenoty1.93601231
31MP0008789_abnormal_olfactory_epithelium1.88992049
32MP0005248_abnormal_Harderian_gland1.86863496
33MP0002557_abnormal_social/conspecific_i1.79780998
34MP0001984_abnormal_olfaction1.79520824
35MP0005646_abnormal_pituitary_gland1.75615977
36MP0010386_abnormal_urinary_bladder1.74963459
37MP0003329_amyloid_beta_deposits1.72842258
38MP0003121_genomic_imprinting1.71430304
39MP0009780_abnormal_chondrocyte_physiolo1.70159186
40MP0001188_hyperpigmentation1.68155442
41MP0004811_abnormal_neuron_physiology1.65217524
42MP0005645_abnormal_hypothalamus_physiol1.64676543
43MP0000537_abnormal_urethra_morphology1.60710707
44MP0004133_heterotaxia1.60232826
45MP0000955_abnormal_spinal_cord1.58904894
46MP0004142_abnormal_muscle_tone1.56344528
47MP0002882_abnormal_neuron_morphology1.52603471
48MP0008569_lethality_at_weaning1.51377288
49MP0001905_abnormal_dopamine_level1.50374519
50MP0002909_abnormal_adrenal_gland1.47634441
51MP0001502_abnormal_circadian_rhythm1.47049694
52MP0003941_abnormal_skin_development1.43999953
53MP0008877_abnormal_DNA_methylation1.42234896
54MP0003119_abnormal_digestive_system1.42230353
55MP0003879_abnormal_hair_cell1.40882362
56MP0003890_abnormal_embryonic-extraembry1.40574256
57MP0002066_abnormal_motor_capabilities/c1.39672350
58MP0001293_anophthalmia1.39421071
59MP0002638_abnormal_pupillary_reflex1.37800230
60MP0003937_abnormal_limbs/digits/tail_de1.31995319
61MP0002938_white_spotting1.31546214
62MP0003122_maternal_imprinting1.31444663
63MP0005551_abnormal_eye_electrophysiolog1.31377605
64MP0004742_abnormal_vestibular_system1.31117192
65MP0000647_abnormal_sebaceous_gland1.30077745
66MP0002254_reproductive_system_inflammat1.24820193
67MP0002837_dystrophic_cardiac_calcinosis1.24741055
68MP0003787_abnormal_imprinting1.22664246
69MP0002697_abnormal_eye_size1.22341022
70MP0002233_abnormal_nose_morphology1.20951667
71MP0000579_abnormal_nail_morphology1.18726546
72MP0003136_yellow_coat_color1.16220927
73MP0009672_abnormal_birth_weight1.14688769
74MP0002229_neurodegeneration1.13952004
75MP0002152_abnormal_brain_morphology1.11717634
76MP0004885_abnormal_endolymph1.10744116
77MP0002876_abnormal_thyroid_physiology1.06284735
78MP0006072_abnormal_retinal_apoptosis1.04650452
79MP0003123_paternal_imprinting1.03767133
80MP0002752_abnormal_somatic_nervous1.02243729
81MP0009703_decreased_birth_body1.01005830
82MP0001963_abnormal_hearing_physiology1.00817802
83MP0000751_myopathy0.99181183
84MP0003633_abnormal_nervous_system0.98587851
85MP0000631_abnormal_neuroendocrine_gland0.98429712
86MP0000427_abnormal_hair_cycle0.97457985
87MP0002102_abnormal_ear_morphology0.95921043
88MP0003011_delayed_dark_adaptation0.95869052
89MP0002069_abnormal_eating/drinking_beha0.94072741
90MP0003942_abnormal_urinary_system0.93561404
91MP0003631_nervous_system_phenotype0.92829350
92MP0000049_abnormal_middle_ear0.92329686
93MP0001286_abnormal_eye_development0.90346852
94MP0003634_abnormal_glial_cell0.89180644
95MP0008932_abnormal_embryonic_tissue0.89107666
96MP0003385_abnormal_body_wall0.88426290
97MP0003755_abnormal_palate_morphology0.88339527
98MP0005379_endocrine/exocrine_gland_phen0.87439805
99MP0005394_taste/olfaction_phenotype0.87242255
100MP0005499_abnormal_olfactory_system0.87242255
101MP0005391_vision/eye_phenotype0.85574138
102MP0000569_abnormal_digit_pigmentation0.85460847
103MP0001986_abnormal_taste_sensitivity0.84755074
104MP0005367_renal/urinary_system_phenotyp0.84632766
105MP0000516_abnormal_urinary_system0.84632766
106MP0004085_abnormal_heartbeat0.84544727
107MP0004145_abnormal_muscle_electrophysio0.84157297
108MP0004197_abnormal_fetal_growth/weight/0.81447888
109MP0002751_abnormal_autonomic_nervous0.81432506
110MP0008872_abnormal_physiological_respon0.79818930
111MP0000013_abnormal_adipose_tissue0.79815047
112MP0002081_perinatal_lethality0.79175855
113MP0003632_abnormal_nervous_system0.78543113
114MP0005171_absent_coat_pigmentation0.78215820
115MP0005535_abnormal_body_temperature0.77807922
116MP0002084_abnormal_developmental_patter0.77519867
117MP0000462_abnormal_digestive_system0.76209378
118MP0003567_abnormal_fetal_cardiomyocyte0.75715562
119MP0003938_abnormal_ear_development0.75503289
120MP0000026_abnormal_inner_ear0.75090088
121MP0000383_abnormal_hair_follicle0.74682337
122MP0000604_amyloidosis0.74287576
123MP0002085_abnormal_embryonic_tissue0.73667998
124MP0002090_abnormal_vision0.72425407
125MP0005253_abnormal_eye_physiology0.69759327
126MP0004215_abnormal_myocardial_fiber0.67230482
127MP0002163_abnormal_gland_morphology0.65876241
128MP0000920_abnormal_myelination0.65085383
129MP0001664_abnormal_digestion0.64923992
130MP0003137_abnormal_impulse_conducting0.64395483
131MP0001485_abnormal_pinna_reflex0.63415095
132MP0001299_abnormal_eye_distance/0.62432490
133MP0003861_abnormal_nervous_system0.62382359
134MP0008874_decreased_physiological_sensi0.62100965
135MP0006292_abnormal_olfactory_placode0.61860017
136MP0003283_abnormal_digestive_organ0.57876335
137MP0001177_atelectasis0.57705475
138MP0001943_abnormal_respiration0.55063080
139MP0001348_abnormal_lacrimal_gland0.54573798
140MP0000538_abnormal_urinary_bladder0.52411262
141MP0005187_abnormal_penis_morphology0.52175725
142MP0005195_abnormal_posterior_eye0.52118123

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.72336696
2Myokymia (HP:0002411)5.79433087
3Focal seizures (HP:0007359)5.06664752
4Epileptic encephalopathy (HP:0200134)4.85847205
5Visual hallucinations (HP:0002367)4.79008085
6Atonic seizures (HP:0010819)4.57606301
7Febrile seizures (HP:0002373)4.49929347
8Absence seizures (HP:0002121)4.07682472
9Progressive cerebellar ataxia (HP:0002073)3.90332332
10Dialeptic seizures (HP:0011146)3.80041012
11Hyperventilation (HP:0002883)3.62800942
12Generalized tonic-clonic seizures (HP:0002069)3.58719335
13Supranuclear gaze palsy (HP:0000605)3.51237920
14Limb dystonia (HP:0002451)3.41536934
15Broad-based gait (HP:0002136)3.41137303
16Amblyopia (HP:0000646)3.30437561
17Hepatoblastoma (HP:0002884)3.29124737
18Drooling (HP:0002307)3.15001591
19Excessive salivation (HP:0003781)3.15001591
20Abnormality of the corticospinal tract (HP:0002492)3.10997508
21Neurofibrillary tangles (HP:0002185)3.05402236
22Mutism (HP:0002300)3.04771125
23Gait imbalance (HP:0002141)3.03977021
24Action tremor (HP:0002345)3.01896862
25Epileptiform EEG discharges (HP:0011182)3.00024460
26Cerebral inclusion bodies (HP:0100314)2.98017780
27EEG with generalized epileptiform discharges (HP:0011198)2.90878733
28Polyphagia (HP:0002591)2.90627858
29Cortical dysplasia (HP:0002539)2.89431972
30Ankle clonus (HP:0011448)2.89412765
31Pheochromocytoma (HP:0002666)2.87975778
32Abnormality of the labia minora (HP:0012880)2.87391920
33Gaze-evoked nystagmus (HP:0000640)2.86502372
34Colon cancer (HP:0003003)2.83916458
35Neuroendocrine neoplasm (HP:0100634)2.79046878
36Akinesia (HP:0002304)2.78066520
37Truncal ataxia (HP:0002078)2.76777022
38Papillary thyroid carcinoma (HP:0002895)2.69600612
39Abnormal eating behavior (HP:0100738)2.69547470
40Urinary bladder sphincter dysfunction (HP:0002839)2.65141837
41Hypsarrhythmia (HP:0002521)2.63722029
42Progressive inability to walk (HP:0002505)2.62769841
43Insidious onset (HP:0003587)2.61604096
44Termporal pattern (HP:0011008)2.61604096
45Anxiety (HP:0000739)2.56446265
46Hypothermia (HP:0002045)2.56221908
47Depression (HP:0000716)2.55763968
48Absent speech (HP:0001344)2.55417202
49Impaired vibration sensation in the lower limbs (HP:0002166)2.52200518
50Dysdiadochokinesis (HP:0002075)2.48758588
51Agitation (HP:0000713)2.48026132
52Vitreoretinal degeneration (HP:0000655)2.47311821
53Cutaneous finger syndactyly (HP:0010554)2.44320974
54Poor eye contact (HP:0000817)2.43850602
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43703154
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.43703154
57Spastic gait (HP:0002064)2.42604273
58Dysmetria (HP:0001310)2.42376551
59Fetal akinesia sequence (HP:0001989)2.38589588
60Hemiparesis (HP:0001269)2.37240920
61Medial flaring of the eyebrow (HP:0010747)2.37099324
62Congenital primary aphakia (HP:0007707)2.35855749
63Aplasia/Hypoplasia of the brainstem (HP:0007362)2.28413046
64Hypoplasia of the brainstem (HP:0002365)2.28413046
65Inability to walk (HP:0002540)2.27864571
66Abnormal social behavior (HP:0012433)2.21527046
67Impaired social interactions (HP:0000735)2.21527046
68Bradykinesia (HP:0002067)2.21424936
69Renal hypoplasia (HP:0000089)2.21371296
70Cutaneous syndactyly (HP:0012725)2.20704272
71Retinal dysplasia (HP:0007973)2.20322170
72Specific learning disability (HP:0001328)2.20208208
73Thyroid carcinoma (HP:0002890)2.17805044
74Amyotrophic lateral sclerosis (HP:0007354)2.17512806
75Urinary urgency (HP:0000012)2.15408935
76Bifid tongue (HP:0010297)2.15266396
77Nephrogenic diabetes insipidus (HP:0009806)2.14617912
78Diplopia (HP:0000651)2.14288580
79Abnormality of binocular vision (HP:0011514)2.14288580
80Papilledema (HP:0001085)2.12987288
81Postural instability (HP:0002172)2.10813902
82Genital tract atresia (HP:0001827)2.10037798
83Exotropia (HP:0000577)2.10016660
84Abnormality of salivation (HP:0100755)2.10002101
85Torticollis (HP:0000473)2.09112090
86Poor suck (HP:0002033)2.07469107
87Vaginal atresia (HP:0000148)2.07268945
88Protruding tongue (HP:0010808)2.06046337
89Scanning speech (HP:0002168)2.05961816
90Chorioretinal atrophy (HP:0000533)2.04953098
91Lissencephaly (HP:0001339)2.04769237
92Poor coordination (HP:0002370)2.03560892
93Tubulointerstitial nephritis (HP:0001970)2.02545941
94Abnormal hair whorl (HP:0010721)2.01324889
95Neoplasm of the adrenal cortex (HP:0100641)2.00446978
96Curly hair (HP:0002212)1.99327299
97Focal dystonia (HP:0004373)1.98014832
98Lower limb muscle weakness (HP:0007340)1.97259061
99Absent eyebrow (HP:0002223)1.97245128
100Septo-optic dysplasia (HP:0100842)1.96617885
101Ulnar claw (HP:0001178)1.95887835
102Generalized hypotonia (HP:0001290)1.95418390
103Breast carcinoma (HP:0003002)1.94861091
104Impaired smooth pursuit (HP:0007772)1.94333039
105Blue irides (HP:0000635)1.93463295
106Generalized myoclonic seizures (HP:0002123)1.93112577
107Stereotypic behavior (HP:0000733)1.91186231
108Esotropia (HP:0000565)1.90562283
109Failure to thrive in infancy (HP:0001531)1.90330586
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90230005
111Broad foot (HP:0001769)1.89862385
112Psychosis (HP:0000709)1.88545879
113Scrotal hypoplasia (HP:0000046)1.87190437
114Neoplasm of the adrenal gland (HP:0100631)1.86889961
115Myelomeningocele (HP:0002475)1.86261437
116Postnatal microcephaly (HP:0005484)1.85671851
117Craniofacial dystonia (HP:0012179)1.85169143
118Morphological abnormality of the middle ear (HP:0008609)1.84708102
119Hyperglycinemia (HP:0002154)1.84534822
120Heterochromia iridis (HP:0001100)1.82874446
121Delusions (HP:0000746)1.82182749
122Morphological abnormality of the pyramidal tract (HP:0002062)1.81972837
123Intestinal atresia (HP:0011100)1.79082618
124Open mouth (HP:0000194)1.76008234
125Micropenis (HP:0000054)1.75293897
126Genetic anticipation (HP:0003743)1.74897915
127Hypoventilation (HP:0002791)1.74121550
128Cerebellar dysplasia (HP:0007033)1.73693432
129Sleep apnea (HP:0010535)1.73447485
130Optic nerve hypoplasia (HP:0000609)1.72063376
131Short tibia (HP:0005736)1.71177798
132Gait ataxia (HP:0002066)1.71016311
133Renal dysplasia (HP:0000110)1.70888154
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70744529
135Aqueductal stenosis (HP:0002410)1.70503401
136Bicornuate uterus (HP:0000813)1.70467200
137Pachygyria (HP:0001302)1.67715570
138Pendular nystagmus (HP:0012043)1.67126609
139Abnormality of the astrocytes (HP:0100707)1.66397352
140Astrocytoma (HP:0009592)1.66397352
141Hemivertebrae (HP:0002937)1.65424172
142Concave nail (HP:0001598)1.61769106
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.61417228
144Hyperglycinuria (HP:0003108)1.61271057
145Polymicrogyria (HP:0002126)1.60942555
146Abnormality of the parathyroid morphology (HP:0011766)1.60424701
147Pancreatic fibrosis (HP:0100732)1.60050431
148Postaxial hand polydactyly (HP:0001162)1.59776280
149Decreased testicular size (HP:0008734)1.56701520
150Abnormality of glycine metabolism (HP:0010895)1.56267084
151Abnormality of serine family amino acid metabolism (HP:0010894)1.56267084
152Meningocele (HP:0002435)1.56226995
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.56018002
154Glioma (HP:0009733)1.53006113
155True hermaphroditism (HP:0010459)1.52782812
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.52268681
157Adactyly (HP:0009776)1.52195734
158Labial hypoplasia (HP:0000066)1.52083247
159Ependymoma (HP:0002888)1.51197914
160Type II lissencephaly (HP:0007260)1.50760311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.84479489
2NTRK34.06845532
3CASK3.41873871
4MAP3K93.27313036
5MAP3K43.17527174
6EPHA43.07119759
7TRIM282.95069845
8MAP2K72.89936307
9MINK12.65664832
10NTRK22.29257954
11MAPK132.08796648
12MAP3K121.97319830
13TSSK61.85763311
14DAPK21.84803838
15MAP4K21.84191320
16NTRK11.81375732
17MAP2K41.80146963
18SRPK11.76618264
19PAK61.74508030
20CSNK1G11.73793160
21TNIK1.71706500
22PNCK1.69782852
23PRPF4B1.67207287
24PHKG11.65822824
25PHKG21.65822824
26PLK21.59420945
27MKNK21.49865863
28CDK51.48105996
29GRK51.45607925
30KSR11.42502558
31DYRK31.37358677
32DAPK11.34715704
33CDK191.33260622
34STK38L1.33194392
35SIK21.31829893
36KSR21.24887775
37PRKCG1.22880468
38CAMKK21.22376254
39PKN21.22124410
40LATS21.21058819
41MKNK11.20983649
42BRD41.19952589
43UHMK11.18874901
44DYRK21.11412953
45RIPK41.11127879
46CAMK2A1.10912930
47RPS6KA41.10478232
48CAMKK11.09295105
49CSNK1G21.09173232
50BCR1.08286367
51BCKDK1.06694594
52ARAF1.01396213
53DYRK1A1.00358905
54CDK141.00271357
55OXSR11.00238694
56NUAK10.99951098
57CDK180.97631221
58NME10.96757126
59TTK0.96552895
60SIK30.95507073
61CDK150.93120632
62PLK30.93060974
63PBK0.92810884
64TAF10.90666344
65GRK70.90438156
66CAMK2B0.88163080
67MAP3K20.85326994
68AKT30.85047425
69PAK30.84987826
70CDC70.84332410
71SGK2230.84304999
72SGK4940.84304999
73MARK20.83079127
74CDK11A0.80677953
75SCYL20.78463641
76STK110.76736175
77PIK3CA0.76096241
78PRKCE0.74934230
79CSNK1G30.74280922
80ERBB30.73040033
81BMPR20.72084922
82WNK30.69243810
83MAP3K60.68188111
84PRKD30.67365614
85MET0.66562627
86SGK20.64385311
87ZAK0.63389263
88TESK10.63228518
89PKN10.62171187
90FES0.62123017
91CSNK1E0.61432292
92RET0.59735729
93EIF2AK10.59409086
94PRKCZ0.58156787
95BMPR1B0.57562396
96TYRO30.57268640
97CAMK10.56663660
98EPHB20.56155232
99CAMK2D0.55697396
100NEK60.55681241
101LIMK10.55319317
102CSNK1D0.54046845
103ADRBK10.53501728
104PTK2B0.53154315
105ICK0.52666575
106PLK10.52465371
107MAPK120.52164282
108PRKCH0.50853356
109FGR0.50468347
110SGK10.50175025
111FGFR10.48739901
112LMTK20.47837406
113BRAF0.47815915
114CSNK1A1L0.47520458
115ROCK20.46596849
116LATS10.45816580
117CSNK1A10.45180534
118TAOK10.44737139
119VRK20.44418198
120PRKG10.44052412
121RPS6KA20.43427322
122PINK10.43153884
123MAP3K130.43085980
124STK380.42181981
125INSRR0.40909313
126ALK0.39571851
127CAMK1G0.39053298
128PRKACA0.38675199
129MST40.38393585
130PRKCI0.37932755
131CCNB10.37752399
132FYN0.37742080
133STK390.37154255
134CAMK2G0.36568054
135VRK10.36517987
136RPS6KA30.36509035
137ADRBK20.36503913
138FER0.35923864
139MAP3K100.35119951
140ATM0.34748908
141SGK30.34055022
142PRKCB0.33820915
143FGFR20.33564104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12004846
2Synaptic vesicle cycle_Homo sapiens_hsa047213.50289687
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91962074
4GABAergic synapse_Homo sapiens_hsa047272.76137968
5Morphine addiction_Homo sapiens_hsa050322.59128873
6Circadian entrainment_Homo sapiens_hsa047132.59100307
7Steroid biosynthesis_Homo sapiens_hsa001002.55663965
8Glutamatergic synapse_Homo sapiens_hsa047242.51076350
9Olfactory transduction_Homo sapiens_hsa047402.47597747
10Long-term potentiation_Homo sapiens_hsa047202.34922290
11Dopaminergic synapse_Homo sapiens_hsa047282.29223684
12Amphetamine addiction_Homo sapiens_hsa050312.23539229
13Collecting duct acid secretion_Homo sapiens_hsa049662.19256263
14Serotonergic synapse_Homo sapiens_hsa047262.17709444
15Taste transduction_Homo sapiens_hsa047422.13947454
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12625036
17Insulin secretion_Homo sapiens_hsa049112.06005814
18Cholinergic synapse_Homo sapiens_hsa047252.02899421
19Protein export_Homo sapiens_hsa030601.98971160
20Salivary secretion_Homo sapiens_hsa049701.90704452
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86724473
22Long-term depression_Homo sapiens_hsa047301.81057864
23Cocaine addiction_Homo sapiens_hsa050301.73871874
24Renin secretion_Homo sapiens_hsa049241.72076664
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62113068
26Axon guidance_Homo sapiens_hsa043601.53656799
27Hippo signaling pathway_Homo sapiens_hsa043901.51911711
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49165071
29Oxytocin signaling pathway_Homo sapiens_hsa049211.48163781
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47784989
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47473166
32Gastric acid secretion_Homo sapiens_hsa049711.46520161
33Calcium signaling pathway_Homo sapiens_hsa040201.46350252
34Propanoate metabolism_Homo sapiens_hsa006401.45279240
35Vibrio cholerae infection_Homo sapiens_hsa051101.44093219
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43619646
37Oxidative phosphorylation_Homo sapiens_hsa001901.35272713
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34121846
39Gap junction_Homo sapiens_hsa045401.33407432
40Vitamin B6 metabolism_Homo sapiens_hsa007501.32517065
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28551800
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25773420
43Phototransduction_Homo sapiens_hsa047441.25632847
44Fatty acid elongation_Homo sapiens_hsa000621.24898709
45GnRH signaling pathway_Homo sapiens_hsa049121.23489296
46Tight junction_Homo sapiens_hsa045301.21739905
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20073718
48Cardiac muscle contraction_Homo sapiens_hsa042601.19966056
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16228388
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16026197
51Alzheimers disease_Homo sapiens_hsa050101.12806740
52Type II diabetes mellitus_Homo sapiens_hsa049301.09270616
53cAMP signaling pathway_Homo sapiens_hsa040241.06276220
54Basal cell carcinoma_Homo sapiens_hsa052171.04525331
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02649668
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00560543
57Non-homologous end-joining_Homo sapiens_hsa034500.99663878
58Basal transcription factors_Homo sapiens_hsa030220.99397792
59Estrogen signaling pathway_Homo sapiens_hsa049150.98218979
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.97718924
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97607259
62Parkinsons disease_Homo sapiens_hsa050120.96983317
63Adherens junction_Homo sapiens_hsa045200.96538431
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96293323
65RNA transport_Homo sapiens_hsa030130.95268622
66ErbB signaling pathway_Homo sapiens_hsa040120.94676978
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93367874
68mRNA surveillance pathway_Homo sapiens_hsa030150.92266833
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88577928
70Biosynthesis of amino acids_Homo sapiens_hsa012300.86100574
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.85860043
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85530234
73Melanogenesis_Homo sapiens_hsa049160.84973137
74Glioma_Homo sapiens_hsa052140.83940830
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83565378
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81960552
77Fatty acid metabolism_Homo sapiens_hsa012120.80679428
78Selenocompound metabolism_Homo sapiens_hsa004500.80664563
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78775394
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77511119
81Hedgehog signaling pathway_Homo sapiens_hsa043400.77466051
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77097199
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76036455
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74037749
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73373348
86Pyruvate metabolism_Homo sapiens_hsa006200.72419506
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71381772
88Pancreatic secretion_Homo sapiens_hsa049720.71105012
89Carbon metabolism_Homo sapiens_hsa012000.70696501
90Oocyte meiosis_Homo sapiens_hsa041140.69722205
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66775857
92AMPK signaling pathway_Homo sapiens_hsa041520.65903175
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65798553
94Huntingtons disease_Homo sapiens_hsa050160.65743745
95Alcoholism_Homo sapiens_hsa050340.65514275
96MAPK signaling pathway_Homo sapiens_hsa040100.64427902
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.63563952
98Spliceosome_Homo sapiens_hsa030400.63518114
99RNA degradation_Homo sapiens_hsa030180.62924672
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.62801067
101Thyroid cancer_Homo sapiens_hsa052160.62713235
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61921300
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61676440
104Ras signaling pathway_Homo sapiens_hsa040140.60881445
105Choline metabolism in cancer_Homo sapiens_hsa052310.60552330
106Peroxisome_Homo sapiens_hsa041460.58089477
107Folate biosynthesis_Homo sapiens_hsa007900.57916291
108Dorso-ventral axis formation_Homo sapiens_hsa043200.57583541
109Thyroid hormone synthesis_Homo sapiens_hsa049180.56010438
110Dilated cardiomyopathy_Homo sapiens_hsa054140.55901140
111TGF-beta signaling pathway_Homo sapiens_hsa043500.54773023
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54420942
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53540166
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53502870
115N-Glycan biosynthesis_Homo sapiens_hsa005100.52138117
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52037103
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51844246
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.50742225
119Rheumatoid arthritis_Homo sapiens_hsa053230.50251199
120beta-Alanine metabolism_Homo sapiens_hsa004100.49013383
121Glucagon signaling pathway_Homo sapiens_hsa049220.48505613
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48306214
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48113257
124Phagosome_Homo sapiens_hsa041450.47800932
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46812190
126Circadian rhythm_Homo sapiens_hsa047100.45764030
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.44945694
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.44865581
129Lysine degradation_Homo sapiens_hsa003100.44730158
130RNA polymerase_Homo sapiens_hsa030200.43987767
131Renal cell carcinoma_Homo sapiens_hsa052110.43980641
132Ovarian steroidogenesis_Homo sapiens_hsa049130.43198435
133Endometrial cancer_Homo sapiens_hsa052130.41334107
134Butanoate metabolism_Homo sapiens_hsa006500.39938037
135Wnt signaling pathway_Homo sapiens_hsa043100.38819341
136VEGF signaling pathway_Homo sapiens_hsa043700.38300724
137Type I diabetes mellitus_Homo sapiens_hsa049400.38280074
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38049664
139Rap1 signaling pathway_Homo sapiens_hsa040150.37248968
140Prion diseases_Homo sapiens_hsa050200.37009927
141Regulation of autophagy_Homo sapiens_hsa041400.35856270
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34958736
143Insulin signaling pathway_Homo sapiens_hsa049100.30954403
144Colorectal cancer_Homo sapiens_hsa052100.29713821
145Ether lipid metabolism_Homo sapiens_hsa005650.27122956
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26777367
147Endocytosis_Homo sapiens_hsa041440.26220590
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25825114
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24483505
150African trypanosomiasis_Homo sapiens_hsa051430.21988318
151Inositol phosphate metabolism_Homo sapiens_hsa005620.21838395

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