PCDHA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.02000927
2locomotory exploration behavior (GO:0035641)5.82957338
3neuron cell-cell adhesion (GO:0007158)5.51100094
4synaptic vesicle exocytosis (GO:0016079)5.48144848
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46755206
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.41398074
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38444499
8glutamate secretion (GO:0014047)5.22204072
9protein localization to synapse (GO:0035418)5.20358083
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12877781
11synaptic vesicle maturation (GO:0016188)5.04682152
12regulation of glutamate receptor signaling pathway (GO:1900449)5.00357535
13layer formation in cerebral cortex (GO:0021819)4.91927384
14exploration behavior (GO:0035640)4.83413554
15retinal ganglion cell axon guidance (GO:0031290)4.70718858
16regulation of synaptic vesicle exocytosis (GO:2000300)4.62761068
17neuronal action potential propagation (GO:0019227)4.61828826
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.58096794
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.57151193
20neuron recognition (GO:0008038)4.52131255
21dendritic spine morphogenesis (GO:0060997)4.47926160
22neurotransmitter secretion (GO:0007269)4.33680242
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23472296
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.20839080
25glutamate receptor signaling pathway (GO:0007215)4.18552365
26axonal fasciculation (GO:0007413)4.18513736
27gamma-aminobutyric acid transport (GO:0015812)4.11349722
28regulation of neuronal synaptic plasticity (GO:0048168)4.09864161
29calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.07615154
30regulation of synaptic vesicle transport (GO:1902803)4.03752626
31regulation of synapse structural plasticity (GO:0051823)4.03048196
32synaptic transmission, glutamatergic (GO:0035249)3.94661762
33neuron-neuron synaptic transmission (GO:0007270)3.93372731
34neurotransmitter-gated ion channel clustering (GO:0072578)3.93163109
35proline transport (GO:0015824)3.92951974
36behavioral response to nicotine (GO:0035095)3.90166333
37startle response (GO:0001964)3.77492450
38postsynaptic membrane organization (GO:0001941)3.77083925
39establishment of mitochondrion localization (GO:0051654)3.77001435
40positive regulation of membrane potential (GO:0045838)3.73787626
41olfactory bulb development (GO:0021772)3.69573190
42regulation of dendritic spine morphogenesis (GO:0061001)3.68869028
43long-term memory (GO:0007616)3.66448010
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65032488
45presynaptic membrane assembly (GO:0097105)3.61528139
46positive regulation of synapse maturation (GO:0090129)3.59293754
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58760553
48pyrimidine nucleobase catabolic process (GO:0006208)3.58605718
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57742519
50neurotransmitter transport (GO:0006836)3.54145683
51synaptic vesicle endocytosis (GO:0048488)3.52156854
52protein polyglutamylation (GO:0018095)3.50702210
53cell migration in hindbrain (GO:0021535)3.49983062
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.49247166
55transmission of nerve impulse (GO:0019226)3.46860432
56regulation of postsynaptic membrane potential (GO:0060078)3.43280748
57cerebral cortex radially oriented cell migration (GO:0021799)3.42161926
58spinal cord development (GO:0021510)3.41861139
59negative regulation of microtubule polymerization (GO:0031115)3.40607150
60central nervous system projection neuron axonogenesis (GO:0021952)3.40144231
61cerebellar Purkinje cell differentiation (GO:0021702)3.37718514
62regulation of synaptic plasticity (GO:0048167)3.36372521
63long-term synaptic potentiation (GO:0060291)3.33373760
64dendrite morphogenesis (GO:0048813)3.32787468
65nucleobase catabolic process (GO:0046113)3.30247558
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.28427722
67forebrain neuron differentiation (GO:0021879)3.27454025
68presynaptic membrane organization (GO:0097090)3.26769002
69regulation of neurotransmitter secretion (GO:0046928)3.25287240
70regulation of dendritic spine development (GO:0060998)3.24911174
71activation of protein kinase A activity (GO:0034199)3.24604156
72regulation of neurotransmitter levels (GO:0001505)3.24121867
73synapse assembly (GO:0007416)3.23978531
74dendritic spine organization (GO:0097061)3.23422346
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.23049046
76mitochondrion transport along microtubule (GO:0047497)3.21218980
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.21218980
78heart field specification (GO:0003128)3.20793032
79secondary heart field specification (GO:0003139)3.20793032
80head development (GO:0060322)3.20315652
81axon extension (GO:0048675)3.19459514
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19421951
83positive regulation of neurotransmitter secretion (GO:0001956)3.19190485
84central nervous system neuron axonogenesis (GO:0021955)3.18111377
85positive regulation of dendritic spine development (GO:0060999)3.13845088
86cardiac right ventricle morphogenesis (GO:0003215)3.13358501
87regulation of vesicle fusion (GO:0031338)3.11697759
88neuronal ion channel clustering (GO:0045161)3.09989961
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.08842069
90social behavior (GO:0035176)3.08471168
91intraspecies interaction between organisms (GO:0051703)3.08471168
92positive regulation of mitochondrial fission (GO:0090141)3.07624859
93axoneme assembly (GO:0035082)3.07418083
94neuromuscular process controlling balance (GO:0050885)3.06427776
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05905582
96membrane depolarization (GO:0051899)3.05367325
97positive regulation of neurotransmitter transport (GO:0051590)3.03461529
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02267195
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02049681
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00887787
101positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99923663
102negative regulation of axon guidance (GO:1902668)2.99827377
103learning (GO:0007612)2.99771594
104positive regulation of synapse assembly (GO:0051965)2.98942526
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.98442995
106membrane depolarization during action potential (GO:0086010)2.98081720
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.97501280
108establishment of monopolar cell polarity (GO:0061162)2.97501280
109neuromuscular process (GO:0050905)2.97386792
110nonmotile primary cilium assembly (GO:0035058)2.97324837
111regulation of neurotransmitter transport (GO:0051588)2.94476731
112synapse organization (GO:0050808)2.94476088
113neuromuscular process controlling posture (GO:0050884)2.92864061
114response to auditory stimulus (GO:0010996)2.92054272
115response to histamine (GO:0034776)2.92048886
116axon extension involved in axon guidance (GO:0048846)2.90590409
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.90590409
118synaptic transmission (GO:0007268)2.89120859
119membrane hyperpolarization (GO:0060081)2.88675044
120mechanosensory behavior (GO:0007638)2.86051716
121water-soluble vitamin biosynthetic process (GO:0042364)2.85074253
122establishment of synaptic vesicle localization (GO:0097480)2.85025606
123synaptic vesicle transport (GO:0048489)2.85025606
124regulation of synaptic transmission (GO:0050804)2.84584501
125detection of temperature stimulus involved in sensory perception (GO:0050961)2.84194749
126detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.84194749
127cellular potassium ion homeostasis (GO:0030007)2.84113661
128auditory behavior (GO:0031223)2.81225541
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.79822648
130positive regulation of synaptic transmission (GO:0050806)2.79520580
131neural tube formation (GO:0001841)2.79243067
132specification of organ identity (GO:0010092)2.78024916
133regulation of synapse maturation (GO:0090128)2.77847673
134neuron projection extension (GO:1990138)2.76154376
135short-term memory (GO:0007614)2.71825429
136microtubule bundle formation (GO:0001578)2.68739665
137positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.66646353
138mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.66646353
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.65081760
140adult walking behavior (GO:0007628)2.64983455
141regulation of synapse assembly (GO:0051963)2.64136612
142dendrite development (GO:0016358)2.63858088
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.59923061
144positive regulation of amino acid transport (GO:0051957)2.58092861
145somite development (GO:0061053)2.56480644
146intraciliary transport (GO:0042073)2.55923480
147regulation of Rac GTPase activity (GO:0032314)2.55698232
148ganglion development (GO:0061548)2.54343748
149hippocampus development (GO:0021766)2.53752998
150cerebral cortex cell migration (GO:0021795)2.48096075
151innervation (GO:0060384)2.47915160
152DNA damage response, detection of DNA damage (GO:0042769)2.47162233
153regulation of axon guidance (GO:1902667)2.46761818
154regulation of telomere maintenance (GO:0032204)2.45924433
155epithelial cilium movement (GO:0003351)2.45544903
156regulation of cilium movement (GO:0003352)2.44414569
157* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.42598933
158intra-S DNA damage checkpoint (GO:0031573)2.42377263
159regulation of development, heterochronic (GO:0040034)2.42255765
160neuron migration (GO:0001764)2.42140802
161glycosphingolipid biosynthetic process (GO:0006688)2.41592886
162axonogenesis (GO:0007409)2.38851630
163chaperone-mediated protein transport (GO:0072321)2.35498864
164negative chemotaxis (GO:0050919)2.35390094
165substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.35126454
166substrate-independent telencephalic tangential migration (GO:0021826)2.35126454
167negative regulation of axonogenesis (GO:0050771)2.34924350
168detection of temperature stimulus (GO:0016048)2.34425892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40343278
2GBX2_23144817_ChIP-Seq_PC3_Human3.80531394
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23355700
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22083743
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11118331
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93847233
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75346138
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75346138
9REST_21632747_ChIP-Seq_MESCs_Mouse2.68971438
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.67869944
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64440207
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61961802
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54827814
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52350584
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47144068
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46606538
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44473467
18TAF15_26573619_Chip-Seq_HEK293_Human2.32086644
19AR_21572438_ChIP-Seq_LNCaP_Human2.26139151
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25803739
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.25309850
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.23157465
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.20331656
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18958170
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.15824778
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15780207
27DROSHA_22980978_ChIP-Seq_HELA_Human2.14001378
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13956767
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12917106
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10374812
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05975367
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85153522
33IGF1R_20145208_ChIP-Seq_DFB_Human1.83740245
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78171256
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.76585875
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74975992
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67993298
38SMAD4_21799915_ChIP-Seq_A2780_Human1.67808970
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67359709
40ZNF274_21170338_ChIP-Seq_K562_Hela1.61912805
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58985615
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55801550
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50410605
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.48858047
45P300_19829295_ChIP-Seq_ESCs_Human1.47819061
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46846373
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.43950369
48EWS_26573619_Chip-Seq_HEK293_Human1.43581838
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43577921
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42201199
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41550983
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40022580
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39176587
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38523610
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35401130
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.35138724
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.34327264
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33743253
59AR_25329375_ChIP-Seq_VCAP_Human1.29918056
60RNF2_27304074_Chip-Seq_NSC_Mouse1.28612858
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28489173
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25251479
63* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24321662
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22516321
65STAT3_23295773_ChIP-Seq_U87_Human1.22104215
66CBP_20019798_ChIP-Seq_JUKART_Human1.20467411
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20467411
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20084363
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19242223
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18134301
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17992191
72AR_19668381_ChIP-Seq_PC3_Human1.17396503
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17368174
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16675001
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15897454
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.14927491
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13476137
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.12697536
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12159287
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12125845
81TCF4_23295773_ChIP-Seq_U87_Human1.10552359
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10410546
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.10060027
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09494776
85FUS_26573619_Chip-Seq_HEK293_Human1.09040530
86JUN_21703547_ChIP-Seq_K562_Human1.06526773
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06280290
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05693618
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05598679
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04840187
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04051177
92RUNX2_22187159_ChIP-Seq_PCA_Human1.02682889
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.02478259
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02043513
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01466670
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01357026
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01348937
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01324133
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01317030
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.01166885
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01155926
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00621505
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.00196277
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00028120
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99821046
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98380028
107IRF1_19129219_ChIP-ChIP_H3396_Human0.98006569
108EST1_17652178_ChIP-ChIP_JURKAT_Human0.97227127
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.96925077
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.96798933
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96051909
112AHR_22903824_ChIP-Seq_MCF-7_Human0.95817888
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95081308
114BCAT_22108803_ChIP-Seq_LS180_Human0.94029512
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93983322
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.93799086
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93734691
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93375579
119TP53_18474530_ChIP-ChIP_U2OS_Human0.92937027
120TP53_22573176_ChIP-Seq_HFKS_Human0.92892830
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92175616
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92159755
123VDR_22108803_ChIP-Seq_LS180_Human0.91984169
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91136364
125ELK1_19687146_ChIP-ChIP_HELA_Human0.90917344
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90662886
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90662886
128TP53_16413492_ChIP-PET_HCT116_Human0.89909907
129ER_23166858_ChIP-Seq_MCF-7_Human0.89439475
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88928657
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87681552
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.87017203
133KDM2B_26808549_Chip-Seq_REH_Human0.85986610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95135872
2MP0003880_abnormal_central_pattern5.46740541
3MP0003635_abnormal_synaptic_transmissio4.08874703
4MP0004270_analgesia3.91814078
5MP0002063_abnormal_learning/memory/cond3.34670667
6MP0009745_abnormal_behavioral_response3.27836358
7MP0001968_abnormal_touch/_nociception3.11661061
8MP0002064_seizures2.97618985
9MP0009046_muscle_twitch2.91265562
10MP0002734_abnormal_mechanical_nocicepti2.84798169
11MP0002572_abnormal_emotion/affect_behav2.84534939
12MP0003890_abnormal_embryonic-extraembry2.52876867
13MP0002653_abnormal_ependyma_morphology2.52803651
14MP0006276_abnormal_autonomic_nervous2.51906909
15MP0001486_abnormal_startle_reflex2.50997846
16MP0002272_abnormal_nervous_system2.50433385
17MP0002735_abnormal_chemical_nociception2.50353856
18MP0005423_abnormal_somatic_nervous2.48740820
19MP0003121_genomic_imprinting2.44912025
20MP0002736_abnormal_nociception_after2.44127776
21MP0002822_catalepsy2.38704215
22MP0002733_abnormal_thermal_nociception2.34134284
23MP0000778_abnormal_nervous_system2.31016882
24MP0001440_abnormal_grooming_behavior2.18684382
25MP0004133_heterotaxia2.18323781
26MP0001970_abnormal_pain_threshold2.12307860
27MP0001501_abnormal_sleep_pattern2.09000194
28MP0003123_paternal_imprinting2.08857186
29MP0008789_abnormal_olfactory_epithelium2.07173813
30MP0004858_abnormal_nervous_system2.05384747
31MP0002184_abnormal_innervation2.05022904
32MP0003329_amyloid_beta_deposits2.03892516
33MP0002067_abnormal_sensory_capabilities2.00327759
34MP0009780_abnormal_chondrocyte_physiolo1.98679687
35MP0006292_abnormal_olfactory_placode1.97311617
36MP0002557_abnormal_social/conspecific_i1.91398112
37MP0001984_abnormal_olfaction1.80394133
38MP0004924_abnormal_behavior1.80295459
39MP0005386_behavior/neurological_phenoty1.80295459
40MP0004811_abnormal_neuron_physiology1.78566509
41MP0008877_abnormal_DNA_methylation1.71260303
42MP0002909_abnormal_adrenal_gland1.70765494
43MP0000955_abnormal_spinal_cord1.67809537
44MP0001529_abnormal_vocalization1.67329163
45MP0003011_delayed_dark_adaptation1.61788728
46MP0008569_lethality_at_weaning1.59095647
47MP0003119_abnormal_digestive_system1.50758999
48MP0005645_abnormal_hypothalamus_physiol1.48982261
49MP0002882_abnormal_neuron_morphology1.48194070
50MP0002066_abnormal_motor_capabilities/c1.44911322
51MP0002160_abnormal_reproductive_system1.42666757
52MP0001293_anophthalmia1.42266538
53MP0001919_abnormal_reproductive_system1.41483515
54MP0001905_abnormal_dopamine_level1.37739840
55MP0003879_abnormal_hair_cell1.36206151
56MP0000751_myopathy1.28054069
57MP0003136_yellow_coat_color1.28005629
58MP0001188_hyperpigmentation1.25373644
59MP0000049_abnormal_middle_ear1.24055927
60MP0003567_abnormal_fetal_cardiomyocyte1.21396558
61MP0002837_dystrophic_cardiac_calcinosis1.18401505
62MP0002152_abnormal_brain_morphology1.18174849
63MP0005253_abnormal_eye_physiology1.16157147
64MP0001502_abnormal_circadian_rhythm1.14744720
65MP0004142_abnormal_muscle_tone1.14415244
66MP0003122_maternal_imprinting1.13854915
67MP0003787_abnormal_imprinting1.12746333
68MP0003633_abnormal_nervous_system1.11787238
69MP0004885_abnormal_endolymph1.10928755
70MP0005646_abnormal_pituitary_gland1.10372269
71MP0004742_abnormal_vestibular_system1.09478308
72MP0003937_abnormal_limbs/digits/tail_de1.05753051
73MP0003631_nervous_system_phenotype1.04667329
74MP0005195_abnormal_posterior_eye1.03793739
75MP0004145_abnormal_muscle_electrophysio1.02198818
76MP0005389_reproductive_system_phenotype1.02021347
77MP0002233_abnormal_nose_morphology1.01178316
78MP0002234_abnormal_pharynx_morphology0.99749635
79MP0002229_neurodegeneration0.98350970
80MP0000631_abnormal_neuroendocrine_gland0.91369760
81MP0005551_abnormal_eye_electrophysiolog0.91276282
82MP0003634_abnormal_glial_cell0.90683469
83MP0002938_white_spotting0.89392639
84MP0000604_amyloidosis0.88861203
85MP0002069_abnormal_eating/drinking_beha0.87599219
86MP0002752_abnormal_somatic_nervous0.86609802
87MP0003755_abnormal_palate_morphology0.85523274
88MP0001963_abnormal_hearing_physiology0.85510914
89MP0003632_abnormal_nervous_system0.85439951
90MP0000566_synostosis0.85383830
91MP0001286_abnormal_eye_development0.84038887
92MP0001177_atelectasis0.83903751
93MP0005391_vision/eye_phenotype0.83565265
94MP0000537_abnormal_urethra_morphology0.82989109
95MP0003315_abnormal_perineum_morphology0.82906897
96MP0004085_abnormal_heartbeat0.81802402
97MP0008874_decreased_physiological_sensi0.80695616
98MP0002102_abnormal_ear_morphology0.80587108
99MP0000013_abnormal_adipose_tissue0.80488206
100MP0010386_abnormal_urinary_bladder0.80089526
101MP0000026_abnormal_inner_ear0.79637064
102MP0003938_abnormal_ear_development0.78852630
103MP0002697_abnormal_eye_size0.78129972
104MP0008872_abnormal_physiological_respon0.77906426
105MP0002081_perinatal_lethality0.77032698
106MP0006072_abnormal_retinal_apoptosis0.76381653
107MP0005187_abnormal_penis_morphology0.73585650
108MP0000569_abnormal_digit_pigmentation0.72402405
109MP0002638_abnormal_pupillary_reflex0.72176865
110MP0005535_abnormal_body_temperature0.72020769
111MP0003861_abnormal_nervous_system0.71006942
112MP0005409_darkened_coat_color0.69811528
113MP0003385_abnormal_body_wall0.69686345
114MP0003941_abnormal_skin_development0.68559980
115MP0005394_taste/olfaction_phenotype0.67347273
116MP0005499_abnormal_olfactory_system0.67347273
117MP0002090_abnormal_vision0.67322811
118MP0004484_altered_response_of0.66023705
119MP0000920_abnormal_myelination0.65849451
120MP0004215_abnormal_myocardial_fiber0.64539480
121MP0001943_abnormal_respiration0.63447913
122MP0003137_abnormal_impulse_conducting0.63219014
123MP0002163_abnormal_gland_morphology0.62997532
124MP0002751_abnormal_autonomic_nervous0.62030882
125MP0002876_abnormal_thyroid_physiology0.58784579
126MP0001348_abnormal_lacrimal_gland0.58629840
127MP0001299_abnormal_eye_distance/0.57918824
128MP0001664_abnormal_digestion0.57277938
129MP0009379_abnormal_foot_pigmentation0.55909294
130MP0004510_myositis0.55080094
131MP0003283_abnormal_digestive_organ0.54929302
132MP0002082_postnatal_lethality0.54601607
133MP0010770_preweaning_lethality0.54601607
134MP0010769_abnormal_survival0.54128302
135MP0001485_abnormal_pinna_reflex0.52005989
136MP0003956_abnormal_body_size0.50887195

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.60515773
2Myokymia (HP:0002411)6.53337332
3Focal seizures (HP:0007359)5.55278289
4Visual hallucinations (HP:0002367)5.29154595
5Atonic seizures (HP:0010819)5.00542532
6Epileptic encephalopathy (HP:0200134)4.63373618
7Febrile seizures (HP:0002373)4.38784109
8Progressive cerebellar ataxia (HP:0002073)4.26748976
9Absence seizures (HP:0002121)3.98180712
10Supranuclear gaze palsy (HP:0000605)3.86479955
11Hyperventilation (HP:0002883)3.72052742
12Generalized tonic-clonic seizures (HP:0002069)3.70004673
13Dialeptic seizures (HP:0011146)3.59336318
14Ankle clonus (HP:0011448)3.51177164
15Medial flaring of the eyebrow (HP:0010747)3.47121753
16Amblyopia (HP:0000646)3.39627429
17Type II lissencephaly (HP:0007260)3.35017746
18Broad-based gait (HP:0002136)3.30659734
19Impaired vibration sensation in the lower limbs (HP:0002166)3.29445533
20Action tremor (HP:0002345)3.28235033
21Cerebral inclusion bodies (HP:0100314)3.27328932
22Hyperglycinemia (HP:0002154)3.25351933
23Truncal ataxia (HP:0002078)3.19023356
24Poor eye contact (HP:0000817)3.17064168
25Drooling (HP:0002307)3.15506300
26Excessive salivation (HP:0003781)3.15506300
27Mutism (HP:0002300)3.14875754
28Lissencephaly (HP:0001339)3.07860989
29Urinary urgency (HP:0000012)3.05584893
30Congenital primary aphakia (HP:0007707)3.04977113
31Urinary bladder sphincter dysfunction (HP:0002839)3.01442570
32Genetic anticipation (HP:0003743)2.99281209
33Impaired social interactions (HP:0000735)2.96716224
34Abnormal social behavior (HP:0012433)2.96716224
35Neurofibrillary tangles (HP:0002185)2.96373031
36Gaze-evoked nystagmus (HP:0000640)2.95988613
37Dysdiadochokinesis (HP:0002075)2.95715609
38Abnormality of the corticospinal tract (HP:0002492)2.95358515
39Anxiety (HP:0000739)2.94627072
40Hepatoblastoma (HP:0002884)2.93144768
41Termporal pattern (HP:0011008)2.91506393
42Insidious onset (HP:0003587)2.91506393
43Amyotrophic lateral sclerosis (HP:0007354)2.89111028
44Polyphagia (HP:0002591)2.87930507
45Abnormal eating behavior (HP:0100738)2.86961728
46Nephrogenic diabetes insipidus (HP:0009806)2.86947275
47Retinal dysplasia (HP:0007973)2.82358298
48Pheochromocytoma (HP:0002666)2.79871437
49Limb dystonia (HP:0002451)2.79527049
50Abnormality of the labia minora (HP:0012880)2.78607263
51Depression (HP:0000716)2.77503882
52Dysmetria (HP:0001310)2.75760975
53Papilledema (HP:0001085)2.74615407
54Diplopia (HP:0000651)2.74499199
55Abnormality of binocular vision (HP:0011514)2.74499199
56Epileptiform EEG discharges (HP:0011182)2.73440329
57Cortical dysplasia (HP:0002539)2.72933012
58Hemiparesis (HP:0001269)2.72658007
59Progressive inability to walk (HP:0002505)2.70777872
60Colon cancer (HP:0003003)2.69212440
61Spastic gait (HP:0002064)2.68265648
62Vaginal atresia (HP:0000148)2.67187302
63Pachygyria (HP:0001302)2.66974381
64EEG with generalized epileptiform discharges (HP:0011198)2.66575646
65Genital tract atresia (HP:0001827)2.64541213
66Scanning speech (HP:0002168)2.60513890
67Hypsarrhythmia (HP:0002521)2.58714680
68Poor coordination (HP:0002370)2.54489207
69Inability to walk (HP:0002540)2.53406231
70Pancreatic fibrosis (HP:0100732)2.52543173
71Neuroendocrine neoplasm (HP:0100634)2.52335407
72Absent speech (HP:0001344)2.51351342
73Agitation (HP:0000713)2.51218877
74Torticollis (HP:0000473)2.43160788
75Fetal akinesia sequence (HP:0001989)2.42361759
76True hermaphroditism (HP:0010459)2.42282766
77Nephronophthisis (HP:0000090)2.37773472
78Thyroid-stimulating hormone excess (HP:0002925)2.30112548
79Rib fusion (HP:0000902)2.29984831
80Impaired smooth pursuit (HP:0007772)2.28498621
81Failure to thrive in infancy (HP:0001531)2.27253692
82Narrow forehead (HP:0000341)2.26796002
83Stereotypic behavior (HP:0000733)2.26329781
84Pancreatic cysts (HP:0001737)2.26023359
85Gait imbalance (HP:0002141)2.24693459
86Generalized myoclonic seizures (HP:0002123)2.24605055
87Postural instability (HP:0002172)2.21746077
88Lower limb muscle weakness (HP:0007340)2.21723180
89Cerebellar dysplasia (HP:0007033)2.21283919
90Abnormality of midbrain morphology (HP:0002418)2.18897093
91Molar tooth sign on MRI (HP:0002419)2.18897093
92Focal dystonia (HP:0004373)2.18291964
93Akinesia (HP:0002304)2.17996172
94Inappropriate behavior (HP:0000719)2.17616548
95Abnormality of the lower motor neuron (HP:0002366)2.16671164
96Abnormality of salivation (HP:0100755)2.16626821
97Acute necrotizing encephalopathy (HP:0006965)2.16192567
98Methylmalonic acidemia (HP:0002912)2.16033084
99Abnormal hair whorl (HP:0010721)2.15817944
100Impaired vibratory sensation (HP:0002495)2.14657440
101Hypoplasia of the brainstem (HP:0002365)2.14040918
102Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14040918
103Spastic tetraplegia (HP:0002510)2.10522097
104Specific learning disability (HP:0001328)2.10333322
105Degeneration of the lateral corticospinal tracts (HP:0002314)2.10193081
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10193081
107Status epilepticus (HP:0002133)2.05371036
108Broad foot (HP:0001769)1.99246907
109Megalencephaly (HP:0001355)1.99097552
110Septo-optic dysplasia (HP:0100842)1.98688854
111Impulsivity (HP:0100710)1.98623028
112Abnormality of the renal medulla (HP:0100957)1.98133741
113Bradykinesia (HP:0002067)1.97476232
114Craniofacial dystonia (HP:0012179)1.97409841
115Micropenis (HP:0000054)1.97159306
116Postaxial hand polydactyly (HP:0001162)1.97096744
117Hip dysplasia (HP:0001385)1.95108956
118Abnormality of ocular smooth pursuit (HP:0000617)1.93997384
119Morphological abnormality of the pyramidal tract (HP:0002062)1.93709936
120Obstructive sleep apnea (HP:0002870)1.92803786
121Acute encephalopathy (HP:0006846)1.92565198
122Protruding tongue (HP:0010808)1.91582688
123Poor suck (HP:0002033)1.91110797
124Sclerocornea (HP:0000647)1.89928580
125Hyperthyroidism (HP:0000836)1.89613007
126Gait ataxia (HP:0002066)1.89586366
127Anomalous pulmonary venous return (HP:0010772)1.89303551
128Exotropia (HP:0000577)1.88691152
129Hemiplegia (HP:0002301)1.87890007
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87756519
131Renal hypoplasia (HP:0000089)1.87647067
132Dysmetric saccades (HP:0000641)1.87506402
133Delusions (HP:0000746)1.86856033
134Neoplasm of the peripheral nervous system (HP:0100007)1.85642644
135Psychosis (HP:0000709)1.85558040
136Apathy (HP:0000741)1.85392033
137Abnormal mitochondria in muscle tissue (HP:0008316)1.84363988
138Optic nerve hypoplasia (HP:0000609)1.83407521
139Lower limb asymmetry (HP:0100559)1.81932188
140Clonus (HP:0002169)1.81790871
141Broad alveolar ridges (HP:0000187)1.81749829
142Abnormality of serine family amino acid metabolism (HP:0010894)1.81085937
143Abnormality of glycine metabolism (HP:0010895)1.81085937
144Generalized hypotonia (HP:0001290)1.80628964
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.77570475
146Absent/shortened dynein arms (HP:0200106)1.77570475
147Polymicrogyria (HP:0002126)1.75329890
148Decreased testicular size (HP:0008734)1.74654850
149Progressive macrocephaly (HP:0004481)1.74283829
150Bony spicule pigmentary retinopathy (HP:0007737)1.74257230
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.73632285
152Occipital encephalocele (HP:0002085)1.73098897
153Methylmalonic aciduria (HP:0012120)1.71307986
154Cerebral edema (HP:0002181)1.71092623
155Meningocele (HP:0002435)1.70013534
156Astigmatism (HP:0000483)1.69185403
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68418383
158Decreased muscle mass (HP:0003199)1.66148247
159Absent eyebrow (HP:0002223)1.66056038
160Anencephaly (HP:0002323)1.63713760
161Bifid tongue (HP:0010297)1.63397321
162Severe Myopia (HP:0011003)1.62207608
163Sleep apnea (HP:0010535)1.61116179
164Mitochondrial inheritance (HP:0001427)1.60134941
165Diastasis recti (HP:0001540)1.59904421
166Left ventricular hypertrophy (HP:0001712)1.59684154
167Hypoplasia of the corpus callosum (HP:0002079)1.57922588
168Neoplasm of the adrenal cortex (HP:0100641)1.57638253
169Chronic hepatic failure (HP:0100626)1.57417390
170Aplasia/Hypoplasia of the lens (HP:0008063)1.57243369
171Labial hypoplasia (HP:0000066)1.56431613
172Scrotal hypoplasia (HP:0000046)1.56229941
173Hemivertebrae (HP:0002937)1.55768377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.62777732
2NTRK34.17911759
3MARK14.13184069
4MAP3K93.52420094
5MAP3K42.99239823
6CASK2.95741824
7MINK12.74898477
8MAP2K72.58444038
9MAP4K22.57998180
10DAPK22.45384086
11MAP3K122.30500668
12IRAK22.23782199
13DYRK32.20705303
14NTRK22.15666016
15PAK62.07406480
16MAP2K41.95709430
17NTRK11.95207411
18TRIM281.94873091
19SIK21.90877355
20PNCK1.90454843
21AKT31.84035263
22KSR11.79135695
23KSR21.78473114
24EPHB21.74679659
25MAPK131.69040140
26PLK21.68585131
27RIPK41.57516026
28DAPK11.55510190
29CDK51.48541901
30GRK51.47293796
31PINK11.47079797
32LATS21.46787623
33PHKG21.44043120
34PHKG11.44043120
35ARAF1.38822369
36IRAK11.33504995
37CAMKK11.33066450
38CDK191.32016488
39BRAF1.27958513
40UHMK11.18785455
41SGK21.15828723
42PRKCG1.14023379
43PRKD31.12281694
44TNIK1.08698794
45FES1.02464733
46CSNK1G11.01435220
47CAMK2A0.98697068
48DYRK1B0.96102373
49CSNK1G20.95105547
50STK380.92292027
51LIMK10.90034609
52SIK30.89873013
53PAK30.88977883
54CDK180.88961205
55DYRK1A0.88784421
56CDK140.86527744
57DYRK20.85263777
58CAMKK20.84887853
59CDK150.84632889
60MAP3K20.83832933
61VRK10.83237767
62MAP3K130.82681252
63BMPR1B0.82215762
64CSNK1A1L0.79459760
65TYRO30.78827484
66PTK2B0.76984411
67STK38L0.76966462
68GRK10.76937834
69MARK20.75155531
70MAP3K60.75125466
71MKNK20.74820983
72STK110.74756098
73RAF10.72971530
74RET0.72626670
75CDK11A0.72363227
76PRPF4B0.71723069
77OXSR10.71294957
78FGR0.70827596
79BCR0.68669379
80CAMK2B0.68175038
81LMTK20.67768246
82PRKCZ0.67564386
83CSNK1A10.67168003
84BCKDK0.66559384
85CAMK10.65406394
86SRPK10.64299630
87STK160.62196211
88PKN10.61729969
89PRKCE0.61727710
90CDC70.60624951
91TIE10.60281032
92SCYL20.59196578
93BMPR20.58280299
94MKNK10.57953050
95PLK30.56800240
96YES10.56320237
97CAMK1G0.56294211
98SGK30.56221240
99SGK4940.55906968
100SGK2230.55906968
101NME10.55484799
102FER0.52858966
103RPS6KA40.52589192
104TAOK10.49879419
105SGK10.49283159
106WNK40.49081403
107PRKCH0.48794234
108CSNK1G30.48567251
109ZAK0.48033206
110WNK30.46237917
111FYN0.45693452
112ROCK20.44128107
113RPS6KB20.42825282
114MAP2K10.42327090
115MAPK150.41834867
116MAPK120.41280487
117RPS6KA20.41015611
118DAPK30.40293256
119RPS6KA30.40013277
120ERBB30.39721329
121MAPK100.39562717
122PRKACA0.38874455
123NUAK10.37867043
124PRKG10.37543378
125CCNB10.37260168
126ALK0.37191525
127ADRBK10.37019625
128BRSK10.36916247
129CAMK40.36556497
130FGFR20.36390682
131PLK10.35620502
132PDK10.34657943
133ADRBK20.34003476
134STK30.33718472
135STK390.33410543
136CAMK2G0.33241009
137CAMK2D0.32993562
138GRK60.32934643
139PDPK10.32585449
140CSNK1E0.32393338

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76699713
2Synaptic vesicle cycle_Homo sapiens_hsa047213.44520237
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67168278
4Long-term potentiation_Homo sapiens_hsa047202.67099708
5GABAergic synapse_Homo sapiens_hsa047272.61369737
6Olfactory transduction_Homo sapiens_hsa047402.60878028
7Glutamatergic synapse_Homo sapiens_hsa047242.57375776
8Circadian entrainment_Homo sapiens_hsa047132.53853489
9Steroid biosynthesis_Homo sapiens_hsa001002.42979212
10Amphetamine addiction_Homo sapiens_hsa050312.42385668
11Morphine addiction_Homo sapiens_hsa050322.33253779
12Dopaminergic synapse_Homo sapiens_hsa047282.25454632
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16123074
14Propanoate metabolism_Homo sapiens_hsa006402.00322379
15Salivary secretion_Homo sapiens_hsa049701.94928527
16Cholinergic synapse_Homo sapiens_hsa047251.92751144
17Taste transduction_Homo sapiens_hsa047421.86968026
18Serotonergic synapse_Homo sapiens_hsa047261.83565592
19Insulin secretion_Homo sapiens_hsa049111.80378519
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80275592
21Long-term depression_Homo sapiens_hsa047301.78275836
22Collecting duct acid secretion_Homo sapiens_hsa049661.75475607
23Gastric acid secretion_Homo sapiens_hsa049711.73647036
24Cocaine addiction_Homo sapiens_hsa050301.71762418
25Renin secretion_Homo sapiens_hsa049241.66694609
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65943415
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62928603
28Protein export_Homo sapiens_hsa030601.62636337
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60751923
30Oxytocin signaling pathway_Homo sapiens_hsa049211.60312119
31Calcium signaling pathway_Homo sapiens_hsa040201.47600110
32Basal transcription factors_Homo sapiens_hsa030221.47060401
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43639816
34Axon guidance_Homo sapiens_hsa043601.41622387
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40249468
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38600651
37Gap junction_Homo sapiens_hsa045401.38150277
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38140347
39GnRH signaling pathway_Homo sapiens_hsa049121.33130659
40RNA polymerase_Homo sapiens_hsa030201.30237603
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27449198
42Estrogen signaling pathway_Homo sapiens_hsa049151.17813409
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16819266
44cAMP signaling pathway_Homo sapiens_hsa040241.16081214
45Phototransduction_Homo sapiens_hsa047441.14399207
46Glioma_Homo sapiens_hsa052141.13952422
47Cardiac muscle contraction_Homo sapiens_hsa042601.12100111
48Vibrio cholerae infection_Homo sapiens_hsa051101.11897458
49Type II diabetes mellitus_Homo sapiens_hsa049301.10407838
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07554822
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06890128
52ErbB signaling pathway_Homo sapiens_hsa040121.05499778
53Hippo signaling pathway_Homo sapiens_hsa043901.05056954
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03391272
55Pyruvate metabolism_Homo sapiens_hsa006201.00023891
56Hedgehog signaling pathway_Homo sapiens_hsa043400.99168495
57Melanogenesis_Homo sapiens_hsa049160.97960133
58Basal cell carcinoma_Homo sapiens_hsa052170.96745237
59RNA degradation_Homo sapiens_hsa030180.94261558
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93457885
61Oocyte meiosis_Homo sapiens_hsa041140.92556588
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92471340
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92189700
64Ribosome_Homo sapiens_hsa030100.92145864
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91915882
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91894823
67Regulation of autophagy_Homo sapiens_hsa041400.90045152
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89637840
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88921371
70Alzheimers disease_Homo sapiens_hsa050100.87226560
71Dorso-ventral axis formation_Homo sapiens_hsa043200.87218673
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86008980
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.77213384
74Oxidative phosphorylation_Homo sapiens_hsa001900.76593895
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76175199
76mRNA surveillance pathway_Homo sapiens_hsa030150.76105505
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75966040
78Fatty acid metabolism_Homo sapiens_hsa012120.75321874
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74412188
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71879396
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71438247
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70779001
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.70752732
84Selenocompound metabolism_Homo sapiens_hsa004500.70231233
85Ether lipid metabolism_Homo sapiens_hsa005650.69413183
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.68504609
87Fanconi anemia pathway_Homo sapiens_hsa034600.68469902
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.68132016
89Non-homologous end-joining_Homo sapiens_hsa034500.67937753
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67490062
91beta-Alanine metabolism_Homo sapiens_hsa004100.66498572
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66188830
93MAPK signaling pathway_Homo sapiens_hsa040100.65600786
94Thyroid hormone synthesis_Homo sapiens_hsa049180.65386939
95VEGF signaling pathway_Homo sapiens_hsa043700.65021421
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64821981
97Pancreatic secretion_Homo sapiens_hsa049720.64462080
98Notch signaling pathway_Homo sapiens_hsa043300.64160983
99Tryptophan metabolism_Homo sapiens_hsa003800.62024547
100Glucagon signaling pathway_Homo sapiens_hsa049220.61517494
101Ras signaling pathway_Homo sapiens_hsa040140.61232080
102Peroxisome_Homo sapiens_hsa041460.60714869
103Butanoate metabolism_Homo sapiens_hsa006500.60609710
104Alcoholism_Homo sapiens_hsa050340.59626936
105Dilated cardiomyopathy_Homo sapiens_hsa054140.59499693
106Proteasome_Homo sapiens_hsa030500.59396527
107RNA transport_Homo sapiens_hsa030130.58856518
108Spliceosome_Homo sapiens_hsa030400.58708550
109Type I diabetes mellitus_Homo sapiens_hsa049400.57536811
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57532256
111Tight junction_Homo sapiens_hsa045300.57097540
112Choline metabolism in cancer_Homo sapiens_hsa052310.56964142
113Parkinsons disease_Homo sapiens_hsa050120.56798123
114Linoleic acid metabolism_Homo sapiens_hsa005910.56570476
115Fat digestion and absorption_Homo sapiens_hsa049750.56528291
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56238096
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56064045
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.53525780
119Arginine and proline metabolism_Homo sapiens_hsa003300.53117431
120Fatty acid degradation_Homo sapiens_hsa000710.52082323
121Vitamin digestion and absorption_Homo sapiens_hsa049770.51965234
122Metabolic pathways_Homo sapiens_hsa011000.51665311
123mTOR signaling pathway_Homo sapiens_hsa041500.49771100
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49493629
125Rap1 signaling pathway_Homo sapiens_hsa040150.49464113
126Renal cell carcinoma_Homo sapiens_hsa052110.49360821
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49100276
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47955572
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46407401
130Endometrial cancer_Homo sapiens_hsa052130.45868000
131AMPK signaling pathway_Homo sapiens_hsa041520.44582224
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44069356
133Insulin signaling pathway_Homo sapiens_hsa049100.43511179
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40290549
135Colorectal cancer_Homo sapiens_hsa052100.39225209
136Glycerolipid metabolism_Homo sapiens_hsa005610.39201250
137Wnt signaling pathway_Homo sapiens_hsa043100.38593650
138Fatty acid elongation_Homo sapiens_hsa000620.38019261
139Endocytosis_Homo sapiens_hsa041440.37489451
140Prion diseases_Homo sapiens_hsa050200.37342756
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37277705
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36665093
143Non-small cell lung cancer_Homo sapiens_hsa052230.35697673
144Bile secretion_Homo sapiens_hsa049760.35382494
145Circadian rhythm_Homo sapiens_hsa047100.34312839
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33779441
147Huntingtons disease_Homo sapiens_hsa050160.33535808
148African trypanosomiasis_Homo sapiens_hsa051430.32860693
149Inositol phosphate metabolism_Homo sapiens_hsa005620.29836999
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28766599
151Melanoma_Homo sapiens_hsa052180.28395388
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26805530

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