PCDHA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.14716936
2substrate-independent telencephalic tangential migration (GO:0021826)4.37660369
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.37660369
4pyrimidine nucleobase catabolic process (GO:0006208)4.36493895
5presynaptic membrane organization (GO:0097090)4.30194799
6dopamine biosynthetic process (GO:0042416)4.19937416
7nonmotile primary cilium assembly (GO:0035058)4.07630404
8dendritic spine morphogenesis (GO:0060997)4.00093962
9presynaptic membrane assembly (GO:0097105)3.82060214
10establishment of mitochondrion localization (GO:0051654)3.73571998
11nucleobase catabolic process (GO:0046113)3.65075095
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.64056038
13mitochondrion transport along microtubule (GO:0047497)3.64056038
14prepulse inhibition (GO:0060134)3.63242054
15protein localization to synapse (GO:0035418)3.58605069
16axonal fasciculation (GO:0007413)3.54639806
17neuron recognition (GO:0008038)3.53312753
18neurofilament cytoskeleton organization (GO:0060052)3.42355558
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34364682
20postsynaptic membrane organization (GO:0001941)3.33708787
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.30100203
22neuron cell-cell adhesion (GO:0007158)3.26418971
23dopamine transport (GO:0015872)3.24502442
24catechol-containing compound biosynthetic process (GO:0009713)3.20823774
25catecholamine biosynthetic process (GO:0042423)3.20823774
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17408173
27auditory behavior (GO:0031223)3.13447673
28regulation of synapse structural plasticity (GO:0051823)3.12267163
29behavioral response to cocaine (GO:0048148)3.11800263
30mechanosensory behavior (GO:0007638)3.08393154
31adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06640383
32synapse assembly (GO:0007416)3.03552888
33synaptic transmission, dopaminergic (GO:0001963)2.99537462
34cell migration in hindbrain (GO:0021535)2.99202850
35synaptic vesicle maturation (GO:0016188)2.98543511
36vocalization behavior (GO:0071625)2.97996441
37transmission of nerve impulse (GO:0019226)2.96952057
38adult walking behavior (GO:0007628)2.94816684
39neurotransmitter-gated ion channel clustering (GO:0072578)2.93480958
40cerebral cortex radially oriented cell migration (GO:0021799)2.92970689
41central nervous system myelination (GO:0022010)2.90613338
42axon ensheathment in central nervous system (GO:0032291)2.90613338
43alkaloid metabolic process (GO:0009820)2.89776763
44positive regulation of synapse assembly (GO:0051965)2.87347281
45negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84798317
46short-term memory (GO:0007614)2.84209803
47catecholamine transport (GO:0051937)2.83681759
48epithelial cilium movement (GO:0003351)2.83538137
49neuron-neuron synaptic transmission (GO:0007270)2.79692705
50toxin metabolic process (GO:0009404)2.78453629
51synaptic transmission, cholinergic (GO:0007271)2.77085468
52spinal cord development (GO:0021510)2.75561981
53adaptation of signaling pathway (GO:0023058)2.74895379
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72645571
55synaptic transmission, glutamatergic (GO:0035249)2.69339774
56response to histamine (GO:0034776)2.68586477
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67173192
58neuron fate determination (GO:0048664)2.66307648
59behavioral response to ethanol (GO:0048149)2.65994914
60serotonin metabolic process (GO:0042428)2.64139998
61positive regulation of gastrulation (GO:2000543)2.63868492
62glycerophospholipid catabolic process (GO:0046475)2.63828392
63negative regulation of appetite (GO:0032099)2.62610094
64negative regulation of response to food (GO:0032096)2.62610094
65membrane repolarization (GO:0086009)2.61749769
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60173731
67intraciliary transport (GO:0042073)2.59845311
68protein localization to cilium (GO:0061512)2.58999530
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57537023
70protein neddylation (GO:0045116)2.56964641
71response to amphetamine (GO:0001975)2.56379271
72membrane depolarization during action potential (GO:0086010)2.56075653
73regulation of dopamine secretion (GO:0014059)2.55946475
74cell proliferation in forebrain (GO:0021846)2.55321195
75somite rostral/caudal axis specification (GO:0032525)2.54989709
76glutamate receptor signaling pathway (GO:0007215)2.54840829
77olfactory bulb development (GO:0021772)2.53232568
78dendrite development (GO:0016358)2.51678826
79retinal ganglion cell axon guidance (GO:0031290)2.51381654
80axon extension (GO:0048675)2.49980012
81response to nicotine (GO:0035094)2.49543800
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.49274247
83phenol-containing compound catabolic process (GO:0019336)2.47390431
84ionotropic glutamate receptor signaling pathway (GO:0035235)2.47093098
85neuronal ion channel clustering (GO:0045161)2.46162151
86somite development (GO:0061053)2.45503700
87brain morphogenesis (GO:0048854)2.45101114
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44580615
89protein complex biogenesis (GO:0070271)2.43801756
90glutamate secretion (GO:0014047)2.43051102
91exploration behavior (GO:0035640)2.42454908
92dendrite morphogenesis (GO:0048813)2.42153173
93regulation of microtubule-based movement (GO:0060632)2.40145872
94primary amino compound metabolic process (GO:1901160)2.39319843
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.39281745
96cerebellar Purkinje cell differentiation (GO:0021702)2.39234316
97membrane repolarization during action potential (GO:0086011)2.38148599
98response to auditory stimulus (GO:0010996)2.37877596
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37801190
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37442600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75706176
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.52349437
3GBX2_23144817_ChIP-Seq_PC3_Human2.96366262
4REST_21632747_ChIP-Seq_MESCs_Mouse2.48553680
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47560820
6VDR_22108803_ChIP-Seq_LS180_Human2.47476800
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44777227
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.36952592
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30657718
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20787978
11ZNF274_21170338_ChIP-Seq_K562_Hela2.18125545
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13681776
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.12514076
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12453475
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09568976
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06863686
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06593355
18TAF15_26573619_Chip-Seq_HEK293_Human1.95980241
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94085501
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.90967524
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84616570
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84203419
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.83931204
24RNF2_27304074_Chip-Seq_NSC_Mouse1.83016936
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79298508
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.78426231
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.76253807
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73690434
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73373003
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73245643
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72831169
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72735474
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71441086
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71441086
35P300_19829295_ChIP-Seq_ESCs_Human1.70352260
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63361086
37SMAD4_21799915_ChIP-Seq_A2780_Human1.57865874
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56107807
39FUS_26573619_Chip-Seq_HEK293_Human1.55457334
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55107569
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54161474
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51556560
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48703645
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45889748
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45691510
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44760106
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42286718
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39116702
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38105690
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.36900894
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35296711
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34997702
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.34410039
54EWS_26573619_Chip-Seq_HEK293_Human1.32449251
55STAT3_23295773_ChIP-Seq_U87_Human1.32337351
56AR_25329375_ChIP-Seq_VCAP_Human1.31871963
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.30904898
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30887656
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30887656
60DROSHA_22980978_ChIP-Seq_HELA_Human1.30474382
61IGF1R_20145208_ChIP-Seq_DFB_Human1.29995387
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28501091
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27142035
64BCAT_22108803_ChIP-Seq_LS180_Human1.26843951
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26207288
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24021202
67TCF4_23295773_ChIP-Seq_U87_Human1.21707950
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.19971514
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16908749
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16695500
71CBP_20019798_ChIP-Seq_JUKART_Human1.16433547
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16433547
73ER_23166858_ChIP-Seq_MCF-7_Human1.16195345
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12985158
75RUNX2_22187159_ChIP-Seq_PCA_Human1.12878577
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11789492
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10989306
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.09235547
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08203664
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.07549297
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07470564
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07060915
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06450807
84IRF1_19129219_ChIP-ChIP_H3396_Human1.06295069
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06218574
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05817334
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05085619
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.04924412
89TP53_22573176_ChIP-Seq_HFKS_Human1.04422085
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04259742
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04073394
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02563483
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02329080
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.01808008
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99830060
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99696717
97JUN_21703547_ChIP-Seq_K562_Human0.99369764
98TCF4_22108803_ChIP-Seq_LS180_Human0.98939394
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98811387
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.97331885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.21246051
2MP0003122_maternal_imprinting3.16947472
3MP0002822_catalepsy3.06791703
4MP0003123_paternal_imprinting2.58873073
5MP0008877_abnormal_DNA_methylation2.52426262
6MP0003121_genomic_imprinting2.49288434
7MP0006292_abnormal_olfactory_placode2.39328819
8MP0004859_abnormal_synaptic_plasticity2.31599298
9MP0009046_muscle_twitch2.26238239
10MP0005423_abnormal_somatic_nervous2.26002321
11MP0000778_abnormal_nervous_system2.24639826
12MP0003880_abnormal_central_pattern2.23176319
13MP0001188_hyperpigmentation2.15394944
14MP0009745_abnormal_behavioral_response2.10085963
15MP0002272_abnormal_nervous_system2.07117792
16MP0003635_abnormal_synaptic_transmissio2.05108559
17MP0002909_abnormal_adrenal_gland2.02865996
18MP0005646_abnormal_pituitary_gland1.99514801
19MP0001905_abnormal_dopamine_level1.94263603
20MP0006276_abnormal_autonomic_nervous1.92057183
21MP0004270_analgesia1.92049791
22MP0001968_abnormal_touch/_nociception1.85830811
23MP0002734_abnormal_mechanical_nocicepti1.85167837
24MP0002837_dystrophic_cardiac_calcinosis1.82550060
25MP0001984_abnormal_olfaction1.82188544
26MP0001529_abnormal_vocalization1.81981515
27MP0002063_abnormal_learning/memory/cond1.81106492
28MP0008789_abnormal_olfactory_epithelium1.80023114
29MP0002572_abnormal_emotion/affect_behav1.77864668
30MP0005499_abnormal_olfactory_system1.75262458
31MP0005394_taste/olfaction_phenotype1.75262458
32MP0002557_abnormal_social/conspecific_i1.70077945
33MP0002735_abnormal_chemical_nociception1.67286393
34MP0005551_abnormal_eye_electrophysiolog1.65967531
35MP0002064_seizures1.65867508
36MP0004142_abnormal_muscle_tone1.65016478
37MP0005645_abnormal_hypothalamus_physiol1.61521523
38MP0002102_abnormal_ear_morphology1.61011942
39MP0002653_abnormal_ependyma_morphology1.59175036
40MP0002184_abnormal_innervation1.57331116
41MP0001486_abnormal_startle_reflex1.56894696
42MP0004133_heterotaxia1.54040523
43MP0000631_abnormal_neuroendocrine_gland1.53186830
44MP0001440_abnormal_grooming_behavior1.50498858
45MP0003890_abnormal_embryonic-extraembry1.47943841
46MP0001970_abnormal_pain_threshold1.46556954
47MP0002733_abnormal_thermal_nociception1.46231003
48MP0000955_abnormal_spinal_cord1.45095951
49MP0002067_abnormal_sensory_capabilities1.42531985
50MP0002638_abnormal_pupillary_reflex1.42422364
51MP0004742_abnormal_vestibular_system1.39762040
52MP0004924_abnormal_behavior1.33337030
53MP0005386_behavior/neurological_phenoty1.33337030
54MP0002736_abnormal_nociception_after1.32756652
55MP0004885_abnormal_endolymph1.32266202
56MP0002882_abnormal_neuron_morphology1.28604043
57MP0004145_abnormal_muscle_electrophysio1.25280865
58MP0006072_abnormal_retinal_apoptosis1.24905261
59MP0002163_abnormal_gland_morphology1.24753184
60MP0008872_abnormal_physiological_respon1.24596610
61MP0009379_abnormal_foot_pigmentation1.21517025
62MP0002752_abnormal_somatic_nervous1.18857603
63MP0005187_abnormal_penis_morphology1.18472732
64MP0003646_muscle_fatigue1.17877518
65MP0001986_abnormal_taste_sensitivity1.17521706
66MP0005379_endocrine/exocrine_gland_phen1.14514021
67MP0005195_abnormal_posterior_eye1.09613098
68MP0004811_abnormal_neuron_physiology1.09567646
69MP0001485_abnormal_pinna_reflex1.08129585
70MP0003195_calcinosis1.05174184
71MP0003011_delayed_dark_adaptation1.04366290
72MP0002152_abnormal_brain_morphology1.02458997
73MP0003942_abnormal_urinary_system1.01400138
74MP0001501_abnormal_sleep_pattern0.99241489
75MP0000427_abnormal_hair_cycle0.98347255
76MP0002229_neurodegeneration0.95946856
77MP0002066_abnormal_motor_capabilities/c0.95062667
78MP0001502_abnormal_circadian_rhythm0.94745525
79MP0001293_anophthalmia0.92649704
80MP0002938_white_spotting0.92084568
81MP0002876_abnormal_thyroid_physiology0.89555741
82MP0003315_abnormal_perineum_morphology0.88898532
83MP0005084_abnormal_gallbladder_morpholo0.88547080
84MP0003119_abnormal_digestive_system0.88496053
85MP0002234_abnormal_pharynx_morphology0.88254766
86MP0000049_abnormal_middle_ear0.88190329
87MP0000026_abnormal_inner_ear0.85370336
88MP0004085_abnormal_heartbeat0.84580384
89MP0003633_abnormal_nervous_system0.83273279
90MP0003861_abnormal_nervous_system0.82233020
91MP0005253_abnormal_eye_physiology0.80195970
92MP0001963_abnormal_hearing_physiology0.76253469
93MP0002233_abnormal_nose_morphology0.76063263
94MP0003879_abnormal_hair_cell0.75608014
95MP0003631_nervous_system_phenotype0.75402969
96MP0001944_abnormal_pancreas_morphology0.74431452
97MP0002069_abnormal_eating/drinking_beha0.73464230
98MP0002160_abnormal_reproductive_system0.73262078
99MP0002090_abnormal_vision0.69579546
100MP0002751_abnormal_autonomic_nervous0.69542857

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)5.97974550
2Myokymia (HP:0002411)4.08660254
3Molar tooth sign on MRI (HP:0002419)3.69964896
4Abnormality of midbrain morphology (HP:0002418)3.69964896
5Agitation (HP:0000713)3.68169976
6Pancreatic fibrosis (HP:0100732)3.51877998
7Medial flaring of the eyebrow (HP:0010747)3.50438194
8Gait imbalance (HP:0002141)3.39402065
9Nephronophthisis (HP:0000090)3.31020815
10Polyphagia (HP:0002591)3.18916334
11Hepatoblastoma (HP:0002884)3.15636232
12Epileptic encephalopathy (HP:0200134)3.09719964
13Focal motor seizures (HP:0011153)3.00020745
14Focal seizures (HP:0007359)2.93375730
15Congenital primary aphakia (HP:0007707)2.92570713
16True hermaphroditism (HP:0010459)2.86962146
17Febrile seizures (HP:0002373)2.82363603
18Drooling (HP:0002307)2.77641938
19Nephrogenic diabetes insipidus (HP:0009806)2.73931675
20Neoplasm of the adrenal cortex (HP:0100641)2.71963609
21Pancreatic cysts (HP:0001737)2.69534952
22Progressive cerebellar ataxia (HP:0002073)2.68931021
23Broad-based gait (HP:0002136)2.64372762
24Hypothermia (HP:0002045)2.59695990
25Abnormality of the renal medulla (HP:0100957)2.54809597
26Abnormal rod and cone electroretinograms (HP:0008323)2.54630303
27Abnormal pancreas size (HP:0012094)2.51917063
28Excessive salivation (HP:0003781)2.50957581
29Chronic hepatic failure (HP:0100626)2.39872371
30Genital tract atresia (HP:0001827)2.39850328
31Hyperventilation (HP:0002883)2.36829651
32Acute necrotizing encephalopathy (HP:0006965)2.36742898
33Hypsarrhythmia (HP:0002521)2.35917131
34Vaginal atresia (HP:0000148)2.35795120
35EEG with generalized epileptiform discharges (HP:0011198)2.35275931
36Abnormal eating behavior (HP:0100738)2.35248215
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32812359
38Epileptiform EEG discharges (HP:0011182)2.32656526
39Poor coordination (HP:0002370)2.30132475
40Anencephaly (HP:0002323)2.27199708
41Progressive macrocephaly (HP:0004481)2.26711878
42Abnormality of the labia minora (HP:0012880)2.24551596
43Generalized tonic-clonic seizures (HP:0002069)2.24110203
44Sclerocornea (HP:0000647)2.19851089
45Increased hepatocellular lipid droplets (HP:0006565)2.19815033
46Poor suck (HP:0002033)2.16757385
47Dialeptic seizures (HP:0011146)2.14964933
48Inability to walk (HP:0002540)2.13818722
49Morphological abnormality of the pyramidal tract (HP:0002062)2.13754600
50Atonic seizures (HP:0010819)2.11333173
51Lipid accumulation in hepatocytes (HP:0006561)2.11080370
52Decreased circulating renin level (HP:0003351)2.10731906
53Fetal akinesia sequence (HP:0001989)2.06540683
54Acute encephalopathy (HP:0006846)2.06396538
55Narrow forehead (HP:0000341)2.06285253
56Hemiparesis (HP:0001269)2.03333067
57Abnormality of the corticospinal tract (HP:0002492)2.03009741
58Renal Fanconi syndrome (HP:0001994)2.01689448
59Intestinal atresia (HP:0011100)2.01254835
60Adrenal hypoplasia (HP:0000835)1.99639832
61Mitochondrial inheritance (HP:0001427)1.98253110
62Muscular hypotonia of the trunk (HP:0008936)1.97411609
63Abnormal mitochondria in muscle tissue (HP:0008316)1.97133443
64Congenital stationary night blindness (HP:0007642)1.96644232
65Enlarged penis (HP:0000040)1.96586140
66Status epilepticus (HP:0002133)1.96567390
67Cystic liver disease (HP:0006706)1.95984592
68Methylmalonic acidemia (HP:0002912)1.95714435
69Pachygyria (HP:0001302)1.95065463
70Spastic tetraplegia (HP:0002510)1.94539970
71Abnormal drinking behavior (HP:0030082)1.93586153
72Polydipsia (HP:0001959)1.93586153
73Abnormality of renal resorption (HP:0011038)1.93569432
74Lissencephaly (HP:0001339)1.91699043
75Absence seizures (HP:0002121)1.91114520
76Osteomalacia (HP:0002749)1.89153209
77Specific learning disability (HP:0001328)1.88755031
78Oligodactyly (hands) (HP:0001180)1.87597097
79Optic nerve hypoplasia (HP:0000609)1.87066289
80Restlessness (HP:0000711)1.86492711
81Rib fusion (HP:0000902)1.82630011
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.82625264
83Degeneration of the lateral corticospinal tracts (HP:0002314)1.80889578
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80889578
853-Methylglutaconic aciduria (HP:0003535)1.80479360
86Pendular nystagmus (HP:0012043)1.80227457
87Abnormal hair whorl (HP:0010721)1.80101032
88Postaxial hand polydactyly (HP:0001162)1.79932884
89Double outlet right ventricle (HP:0001719)1.79384304
90Congenital malformation of the right heart (HP:0011723)1.79384304
91Hypogonadotrophic hypogonadism (HP:0000044)1.79006123
92Hypomagnesemia (HP:0002917)1.78945234
93Increased CSF lactate (HP:0002490)1.78887919
94Bony spicule pigmentary retinopathy (HP:0007737)1.77937818
95Type II lissencephaly (HP:0007260)1.77460349
96Dyskinesia (HP:0100660)1.75505721
97Amblyopia (HP:0000646)1.75359798
98Congenital hepatic fibrosis (HP:0002612)1.75306057
99Male pseudohermaphroditism (HP:0000037)1.74549503
100Hyperphosphaturia (HP:0003109)1.74413932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.29758494
2STK164.10696875
3MARK13.34573755
4FRK3.33561528
5PINK13.20181148
6MAP3K42.73698421
7WNK42.52518030
8MAPK132.30222525
9MAP2K72.29759323
10NTRK22.24641622
11WNK32.16595093
12TNIK2.01455862
13NTRK32.01130442
14MAP3K91.88886984
15BMPR1B1.81022964
16STK391.78283709
17DYRK21.73705743
18MAP4K21.68212265
19CSNK1G21.67301635
20PAK31.63395727
21EPHA41.57390854
22ADRBK21.50551246
23MINK11.48655410
24PHKG21.47648451
25PHKG11.47648451
26CSNK1G11.46332959
27MAP2K41.42542993
28PNCK1.42179328
29PRKCG1.41931532
30TLK11.40528153
31CSNK1G31.39667756
32EPHB21.37158594
33MAPKAPK51.20640846
34GRK11.20017741
35MAP3K121.16124075
36DAPK21.05497841
37PLK21.01410365
38CAMK1G0.96734314
39FGFR20.96467682
40BCR0.96154095
41SGK2230.95453995
42SGK4940.95453995
43SIK20.94682777
44NUAK10.94612475
45SGK20.94274771
46OXSR10.93737035
47CDK50.91906270
48CAMK2A0.90827622
49ZAK0.89940228
50BCKDK0.88583857
51CAMK1D0.84883860
52BRAF0.81037154
53INSRR0.80355636
54STK110.79989177
55PIK3CA0.79885197
56CSNK1A1L0.76057868
57AKT30.75282048
58PRKCZ0.74678257
59PRKCE0.73927959
60CAMK2D0.73162261
61CAMK2B0.65705055
62DYRK1A0.60596743
63PRKACA0.58788426
64TRIM280.58031137
65DMPK0.57308462
66MAP3K110.56505339
67IRAK10.55091799
68SGK10.53873230
69PRKD30.52363771
70UHMK10.51447093
71GRK70.51235332
72CSNK1E0.50152114
73PKN10.49069492
74CAMK10.48771724
75CCNB10.48310995
76RPS6KA20.47211396
77PRKG10.46966076
78CAMKK20.45128419
79KSR10.44882004
80DYRK30.42267249
81ADRBK10.42088457
82CDK140.41644525
83CAMK2G0.41374735
84TIE10.41263579
85CAMKK10.40542021
86CSNK1A10.39525490
87MARK20.38545203
88PLK40.38492144
89SGK30.37842725
90PRKACB0.37452991
91MAP3K60.37067577
92GRK50.35720817
93TYRO30.35488882
94RPS6KA30.33388521
95LIMK10.33258437
96PRKAA10.32912184
97CSNK1D0.32854224
98ACVR1B0.32538400
99MKNK20.32398078
100CDK150.32196633

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23929843
2Oxidative phosphorylation_Homo sapiens_hsa001902.84579907
3Parkinsons disease_Homo sapiens_hsa050122.54182101
4Cocaine addiction_Homo sapiens_hsa050302.41138427
5Cardiac muscle contraction_Homo sapiens_hsa042602.41039083
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29023442
7Dopaminergic synapse_Homo sapiens_hsa047282.11325613
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07334037
9GABAergic synapse_Homo sapiens_hsa047272.05194814
10Morphine addiction_Homo sapiens_hsa050322.02532250
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02176444
12Synaptic vesicle cycle_Homo sapiens_hsa047212.02175840
13Insulin secretion_Homo sapiens_hsa049111.99380567
14Glutamatergic synapse_Homo sapiens_hsa047241.96297628
15Phototransduction_Homo sapiens_hsa047441.91044825
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.90836430
17Amphetamine addiction_Homo sapiens_hsa050311.86775224
18Circadian entrainment_Homo sapiens_hsa047131.78624060
19Alzheimers disease_Homo sapiens_hsa050101.71641689
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71301315
21Butanoate metabolism_Homo sapiens_hsa006501.66980305
22Collecting duct acid secretion_Homo sapiens_hsa049661.66689227
23Taste transduction_Homo sapiens_hsa047421.62435264
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61812807
25Serotonergic synapse_Homo sapiens_hsa047261.57775778
26Huntingtons disease_Homo sapiens_hsa050161.53591825
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42539854
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35991858
29Cholinergic synapse_Homo sapiens_hsa047251.28119874
30Linoleic acid metabolism_Homo sapiens_hsa005911.25969737
31Tryptophan metabolism_Homo sapiens_hsa003801.24392389
32Protein export_Homo sapiens_hsa030601.23264821
33Long-term depression_Homo sapiens_hsa047301.21989288
34Steroid biosynthesis_Homo sapiens_hsa001001.21501952
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18581202
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14193920
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11390932
38Axon guidance_Homo sapiens_hsa043601.08939807
39Peroxisome_Homo sapiens_hsa041461.00840837
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00711344
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98274980
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97229252
43Renin secretion_Homo sapiens_hsa049240.97212749
44Olfactory transduction_Homo sapiens_hsa047400.96961729
45Ether lipid metabolism_Homo sapiens_hsa005650.95836393
46Gastric acid secretion_Homo sapiens_hsa049710.93794443
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93010004
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92766910
49Folate biosynthesis_Homo sapiens_hsa007900.91563994
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.88640476
51Gap junction_Homo sapiens_hsa045400.85590049
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85034186
53Regulation of autophagy_Homo sapiens_hsa041400.84921176
54Caffeine metabolism_Homo sapiens_hsa002320.82993538
55Salivary secretion_Homo sapiens_hsa049700.81216592
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80619842
57Oxytocin signaling pathway_Homo sapiens_hsa049210.79780507
58cAMP signaling pathway_Homo sapiens_hsa040240.75950554
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75353175
60Calcium signaling pathway_Homo sapiens_hsa040200.74315669
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73405379
62Propanoate metabolism_Homo sapiens_hsa006400.72724795
63Hedgehog signaling pathway_Homo sapiens_hsa043400.71232650
64Basal cell carcinoma_Homo sapiens_hsa052170.67362463
65Dorso-ventral axis formation_Homo sapiens_hsa043200.67086543
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66761215
67Chemical carcinogenesis_Homo sapiens_hsa052040.66312639
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65840682
69Thyroid hormone synthesis_Homo sapiens_hsa049180.65679871
70Long-term potentiation_Homo sapiens_hsa047200.65350196
71Sulfur metabolism_Homo sapiens_hsa009200.65000569
72Retinol metabolism_Homo sapiens_hsa008300.64791628
73Vitamin B6 metabolism_Homo sapiens_hsa007500.64055086
74Basal transcription factors_Homo sapiens_hsa030220.63098136
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60160131
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59646608
77Ribosome_Homo sapiens_hsa030100.58898223
78Ovarian steroidogenesis_Homo sapiens_hsa049130.58849633
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58832074
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.54777857
81Alcoholism_Homo sapiens_hsa050340.53901058
82Tyrosine metabolism_Homo sapiens_hsa003500.53007703
83Type II diabetes mellitus_Homo sapiens_hsa049300.52989963
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52650502
85Bile secretion_Homo sapiens_hsa049760.50940516
86Melanogenesis_Homo sapiens_hsa049160.49918873
87beta-Alanine metabolism_Homo sapiens_hsa004100.49440651
88Sulfur relay system_Homo sapiens_hsa041220.48699431
89Nitrogen metabolism_Homo sapiens_hsa009100.48451583
90RNA degradation_Homo sapiens_hsa030180.47352038
91RNA polymerase_Homo sapiens_hsa030200.47135939
92Fatty acid elongation_Homo sapiens_hsa000620.46791455
93Hippo signaling pathway_Homo sapiens_hsa043900.46435284
94Metabolic pathways_Homo sapiens_hsa011000.45972309
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.44807929
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44403054
97GnRH signaling pathway_Homo sapiens_hsa049120.44395250
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44390508
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43061285
100Selenocompound metabolism_Homo sapiens_hsa004500.41872215

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