ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	forebrain neuron differentiation (GO:0021879)	6.61118809
2	microtubule severing (GO:0051013)	6.08463072
3	mitochondrial fusion (GO:0008053)	6.04844204
4	cellular ketone body metabolic process (GO:0046950)	5.87294836
5	protein localization to cilium (GO:0061512)	5.68784357
6	snRNA processing (GO:0016180)	5.42332370
7	seminiferous tubule development (GO:0072520)	5.31980442
8	ketone body metabolic process (GO:1902224)	5.18113082
9	positive regulation of mitochondrial fission (GO:0090141)	5.10491363
10	startle response (GO:0001964)	5.09121617
11	snRNA metabolic process (GO:0016073)	4.90378496
12	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	4.82862690
13	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.82782395
14	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.38115019
15	innervation (GO:0060384)	4.29257406
16	uterus development (GO:0060065)	4.28373419
17	positive regulation of cAMP-mediated signaling (GO:0043950)	4.27541847
18	auditory behavior (GO:0031223)	4.22354660
19	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	4.19853003
20	axonal fasciculation (GO:0007413)	4.17711167
21	lens morphogenesis in camera-type eye (GO:0002089)	4.07739416
22	keratinocyte development (GO:0003334)	4.03192569
23	inner ear receptor cell development (GO:0060119)	3.94582427
24	neuronal action potential propagation (GO:0019227)	3.84414864
25	cochlea development (GO:0090102)	3.83949345
26	RNA localization (GO:0006403)	3.69940202
27	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	3.69292694
28	sequestering of actin monomers (GO:0042989)	3.67057767
29	cullin deneddylation (GO:0010388)	3.63043250
30	pre-miRNA processing (GO:0031054)	3.61664601
31	body morphogenesis (GO:0010171)	3.56308188
32	ganglion development (GO:0061548)	3.44874133
33	regulation of mitochondrial fission (GO:0090140)	3.44037565
34	membrane tubulation (GO:0097320)	3.30538257
35	nonmotile primary cilium assembly (GO:0035058)	3.27718331
36	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.22377151
37	positive regulation of protein depolymerization (GO:1901881)	3.19812375
38	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.17601719
39	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.14775821
40	somite development (GO:0061053)	3.11990152
41	mechanosensory behavior (GO:0007638)	3.11116423
42	centrosome localization (GO:0051642)	3.09721841
43	regulation of axon extension involved in axon guidance (GO:0048841)	3.05393728
44	regulation of lipoprotein metabolic process (GO:0050746)	3.02955301
45	neuron recognition (GO:0008038)	3.02610360
46	embryonic body morphogenesis (GO:0010172)	3.00711737
47	protein deneddylation (GO:0000338)	2.98335081
48	regulation of energy homeostasis (GO:2000505)	2.94821864
49	substrate-independent telencephalic tangential migration (GO:0021826)	2.94549574
50	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.94549574
51	central nervous system projection neuron axonogenesis (GO:0021952)	2.90695598
52	lymphangiogenesis (GO:0001946)	2.89772495
53	regulation of axon guidance (GO:1902667)	2.88687989
54	basic amino acid transport (GO:0015802)	2.88388578
55	cellular response to prostaglandin stimulus (GO:0071379)	2.88242952
56	regulation of establishment of cell polarity (GO:2000114)	2.88202241
57	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.85396203
58	peptidyl-threonine dephosphorylation (GO:0035970)	2.85380490
59	establishment of melanosome localization (GO:0032401)	2.85165590
60	superoxide anion generation (GO:0042554)	2.83902211
61	spinal cord development (GO:0021510)	2.82785927
62	presynaptic membrane organization (GO:0097090)	2.81600874
63	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.79381632
64	regulation of hippo signaling (GO:0035330)	2.79117826
65	establishment of pigment granule localization (GO:0051905)	2.76987981
66	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.69399587
67	DNA integration (GO:0015074)	2.67749556
68	establishment or maintenance of bipolar cell polarity (GO:0061245)	2.67272521
69	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.67272521
70	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.66378560
71	synapse assembly (GO:0007416)	2.66106503
72	regulation of synapse structural plasticity (GO:0051823)	2.65804040
73	organelle transport along microtubule (GO:0072384)	2.64023187
74	reflex (GO:0060004)	2.63694870
75	regulation of cofactor metabolic process (GO:0051193)	2.63236889
76	regulation of coenzyme metabolic process (GO:0051196)	2.63236889
77	DNA replication-dependent nucleosome organization (GO:0034723)	2.62972592
78	DNA replication-dependent nucleosome assembly (GO:0006335)	2.62972592
79	regulation of glutamate receptor signaling pathway (GO:1900449)	2.62937661
80	kidney morphogenesis (GO:0060993)	2.62680861
81	regulation of cilium assembly (GO:1902017)	2.62033645
82	positive regulation of microtubule polymerization (GO:0031116)	2.61492102
83	response to auditory stimulus (GO:0010996)	2.59047477
84	synaptic transmission, glutamatergic (GO:0035249)	2.57041432
85	appendage development (GO:0048736)	2.56844290
86	limb development (GO:0060173)	2.56844290
87	response to dietary excess (GO:0002021)	2.56235089
88	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.55169806
89	pantothenate metabolic process (GO:0015939)	2.54875244
90	behavioral response to nicotine (GO:0035095)	2.54167160
91	cranial nerve structural organization (GO:0021604)	2.53955137
92	positive regulation of protein complex disassembly (GO:0043243)	2.53214774
93	regulation of protein kinase A signaling (GO:0010738)	2.52908554
94	regulation of collateral sprouting (GO:0048670)	2.52522373
95	cranial nerve development (GO:0021545)	2.51383951
96	alanine transport (GO:0032328)	2.50376002
97	lens development in camera-type eye (GO:0002088)	2.49406782
98	pyrimidine nucleobase catabolic process (GO:0006208)	2.48857061
99	spinal cord association neuron differentiation (GO:0021527)	2.48795775
100	melanosome transport (GO:0032402)	2.46725595

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.74692415
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.67332859
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.89864526
4	VDR_22108803_ChIP-Seq_LS180_Human	3.89350060
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.10950528
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.80632639
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.52175082
8	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.40378430
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.37019707
10	PKCTHETA_26484144_Chip-Seq_BREAST_Human	2.35345704
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30546805
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21459922
13	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.14595668
14	ETV2_25802403_ChIP-Seq_MESCs_Mouse	2.11075336
15	REST_21632747_ChIP-Seq_MESCs_Mouse	2.06644368
16	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.05573617
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.04443547
18	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.92489701
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91806057
20	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.81832868
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.75494149
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73682046
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.73308386
24	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.67102701
25	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.63557761
26	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.59297224
27	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58856330
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57995029
29	P300_19829295_ChIP-Seq_ESCs_Human	1.54198036
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52410676
31	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.49707639
32	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.46526392
33	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.46269845
34	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.42461486
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.37777571
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.35469617
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34964019
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31438585
39	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.29989231
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29762092
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28794397
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28752921
43	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.28625586
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28127284
45	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.26027973
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25214293
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23531636
48	DROSHA_22980978_ChIP-Seq_HELA_Human	1.22253908
49	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.22212658
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22190306
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18260046
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17796437
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17752735
54	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17691792
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.17155268
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16373100
57	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.15940035
58	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.15594917
59	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.15594917
60	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.15530063
61	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	1.15324800
62	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.14393182
63	TCF4_23295773_ChIP-Seq_U87_Human	1.13455599
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13046396
65	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.10168707
66	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.07934799
67	EWS_26573619_Chip-Seq_HEK293_Human	1.07743225
68	FUS_26573619_Chip-Seq_HEK293_Human	1.06937567
69	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.06382568
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06191947
71	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.05681169
72	STAT3_23295773_ChIP-Seq_U87_Human	1.05394179
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.05120032
74	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.03988092
75	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.03862428
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.03788589
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03271532
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03161076
79	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.02764797
80	AR_25329375_ChIP-Seq_VCAP_Human	1.00281589
81	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.00271544
82	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00125041
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99522235
84	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.99251185
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98736721
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.97895685
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97496360
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97479183
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96015453
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95065392
91	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.94314427
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93624872
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93613465
94	AHR_22903824_ChIP-Seq_MCF-7_Human	0.92353187
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92130974
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.92130974
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90937960
98	MYC_18940864_ChIP-ChIP_HL60_Human	0.90891803
99	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.90427896
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89723110

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	5.19849578
2	MP0003122_maternal_imprinting	4.39108346
3	MP0005423_abnormal_somatic_nervous	4.24816727
4	MP0003787_abnormal_imprinting	3.71622044
5	MP0003136_yellow_coat_color	3.37114004
6	MP0003121_genomic_imprinting	3.19158556
7	MP0001188_hyperpigmentation	3.08270139
8	MP0008877_abnormal_DNA_methylation	2.91013892
9	MP0004885_abnormal_endolymph	2.86646562
10	MP0003890_abnormal_embryonic-extraembry	2.72274728
11	MP0003315_abnormal_perineum_morphology	2.30687798
12	MP0004742_abnormal_vestibular_system	2.28735975
13	MP0000049_abnormal_middle_ear	2.07636726
14	MP0001485_abnormal_pinna_reflex	2.04537486
15	MP0005187_abnormal_penis_morphology	2.01568512
16	MP0003123_paternal_imprinting	1.96884580
17	MP0004142_abnormal_muscle_tone	1.82331681
18	MP0000778_abnormal_nervous_system	1.80525259
19	MP0001968_abnormal_touch/_nociception	1.78273484
20	MP0002184_abnormal_innervation	1.74405155
21	MP0002733_abnormal_thermal_nociception	1.68967032
22	MP0009046_muscle_twitch	1.63897906
23	MP0001984_abnormal_olfaction	1.61586362
24	MP0006276_abnormal_autonomic_nervous	1.59540063
25	MP0002272_abnormal_nervous_system	1.56495955
26	MP0000955_abnormal_spinal_cord	1.51059884
27	MP0008058_abnormal_DNA_repair	1.46684469
28	MP0002557_abnormal_social/conspecific_i	1.45166551
29	MP0008995_early_reproductive_senescence	1.36383184
30	MP0004859_abnormal_synaptic_plasticity	1.28783520
31	MP0003221_abnormal_cardiomyocyte_apopto	1.26579923
32	MP0000639_abnormal_adrenal_gland	1.25362663
33	MP0001970_abnormal_pain_threshold	1.24999153
34	MP0003941_abnormal_skin_development	1.23642799
35	MP0000631_abnormal_neuroendocrine_gland	1.22103362
36	MP0001986_abnormal_taste_sensitivity	1.21755841
37	MP0008872_abnormal_physiological_respon	1.21638260
38	MP0003635_abnormal_synaptic_transmissio	1.20545339
39	MP0002064_seizures	1.20506258
40	MP0002735_abnormal_chemical_nociception	1.19388996
41	MP0003942_abnormal_urinary_system	1.18008769
42	MP0002067_abnormal_sensory_capabilities	1.15757624
43	MP0004133_heterotaxia	1.15566790
44	MP0002882_abnormal_neuron_morphology	1.13135131
45	MP0005386_behavior/neurological_phenoty	1.10565851
46	MP0004924_abnormal_behavior	1.10565851
47	MP0002752_abnormal_somatic_nervous	1.09161788
48	MP0002102_abnormal_ear_morphology	1.08608621
49	MP0003937_abnormal_limbs/digits/tail_de	1.08404910
50	MP0002063_abnormal_learning/memory/cond	1.08029130
51	MP0001529_abnormal_vocalization	1.06873905
52	MP0005167_abnormal_blood-brain_barrier	1.05775253
53	MP0003878_abnormal_ear_physiology	1.04266183
54	MP0005377_hearing/vestibular/ear_phenot	1.04266183
55	MP0009697_abnormal_copulation	1.04237563
56	MP0002751_abnormal_autonomic_nervous	1.03673831
57	MP0004145_abnormal_muscle_electrophysio	1.03064238
58	MP0002734_abnormal_mechanical_nocicepti	1.01590091
59	MP0001879_abnormal_lymphatic_vessel	1.00488281
60	MP0009745_abnormal_behavioral_response	1.00253792
61	MP0001486_abnormal_startle_reflex	1.00090715
62	MP0002152_abnormal_brain_morphology	0.99684134
63	MP0010386_abnormal_urinary_bladder	0.99173220
64	MP0005551_abnormal_eye_electrophysiolog	0.98494304
65	MP0008789_abnormal_olfactory_epithelium	0.96693536
66	MP0002229_neurodegeneration	0.96283626
67	MP0000026_abnormal_inner_ear	0.95468180
68	MP0000534_abnormal_ureter_morphology	0.94436781
69	MP0000538_abnormal_urinary_bladder	0.94162789
70	MP0005499_abnormal_olfactory_system	0.92903846
71	MP0005394_taste/olfaction_phenotype	0.92903846
72	MP0003119_abnormal_digestive_system	0.92097156
73	MP0002736_abnormal_nociception_after	0.91023097
74	MP0003567_abnormal_fetal_cardiomyocyte	0.89956212
75	MP0002697_abnormal_eye_size	0.89049413
76	MP0003755_abnormal_palate_morphology	0.88968967
77	MP0003861_abnormal_nervous_system	0.88407607
78	MP0001919_abnormal_reproductive_system	0.87384726
79	MP0002572_abnormal_emotion/affect_behav	0.82695928
80	MP0005647_abnormal_sex_gland	0.80802225
81	MP0004484_altered_response_of	0.79176698
82	MP0004811_abnormal_neuron_physiology	0.77960342
83	MP0001502_abnormal_circadian_rhythm	0.77124927
84	MP0006072_abnormal_retinal_apoptosis	0.75431957
85	MP0001286_abnormal_eye_development	0.75306642
86	MP0001963_abnormal_hearing_physiology	0.74488559
87	MP0003935_abnormal_craniofacial_develop	0.74427889
88	MP0009672_abnormal_birth_weight	0.73960793
89	MP0002066_abnormal_motor_capabilities/c	0.73743418
90	MP0002938_white_spotting	0.73332813
91	MP0010368_abnormal_lymphatic_system	0.72477747
92	MP0001501_abnormal_sleep_pattern	0.72417628
93	MP0001849_ear_inflammation	0.71601036
94	MP0003283_abnormal_digestive_organ	0.68661099
95	MP0002069_abnormal_eating/drinking_beha	0.68548032
96	MP0002138_abnormal_hepatobiliary_system	0.67260302
97	MP0004270_analgesia	0.64967715
98	MP0002653_abnormal_ependyma_morphology	0.64768202
99	MP0008569_lethality_at_weaning	0.63768576
100	MP0005253_abnormal_eye_physiology	0.63493881

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal number of erythroid precursors (HP:0012131)	7.71596527
2	Abnormality of cells of the erythroid lineage (HP:0012130)	6.83029243
3	Enlarged penis (HP:0000040)	6.41173796
4	Gonadotropin excess (HP:0000837)	5.47787033
5	Polyphagia (HP:0002591)	4.25258333
6	Agitation (HP:0000713)	3.87521924
7	Reticulocytosis (HP:0001923)	3.86292734
8	Entropion (HP:0000621)	3.85645592
9	Morphological abnormality of the middle ear (HP:0008609)	3.75780253
10	Septo-optic dysplasia (HP:0100842)	3.73055807
11	Abnormality of the labia minora (HP:0012880)	3.61013990
12	Macroorchidism (HP:0000053)	3.59965477
13	Optic nerve hypoplasia (HP:0000609)	3.41355405
14	Genetic anticipation (HP:0003743)	3.35440239
15	Methylmalonic aciduria (HP:0012120)	3.33137387
16	Methylmalonic acidemia (HP:0002912)	3.31847689
17	Focal motor seizures (HP:0011153)	3.28442542
18	Abnormality of homocysteine metabolism (HP:0010919)	3.23261523
19	Homocystinuria (HP:0002156)	3.23261523
20	Poikilocytosis (HP:0004447)	3.22927575
21	Abnormality of reticulocytes (HP:0004312)	3.20068813
22	Abnormality of DNA repair (HP:0003254)	3.18882379
23	Termporal pattern (HP:0011008)	3.12960586
24	Insidious onset (HP:0003587)	3.12960586
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.03324927
26	Failure to thrive in infancy (HP:0001531)	3.02617068
27	Severe Myopia (HP:0011003)	2.98395372
28	Colon cancer (HP:0003003)	2.86496103
29	Poikiloderma (HP:0001029)	2.86274693
30	Morphological abnormality of the inner ear (HP:0011390)	2.86237968
31	Scrotal hypoplasia (HP:0000046)	2.77314012
32	Abnormality of magnesium homeostasis (HP:0004921)	2.68416536
33	Patellar aplasia (HP:0006443)	2.63254525
34	Hyperthyroidism (HP:0000836)	2.53875568
35	Poor suck (HP:0002033)	2.47335387
36	Midline defect of the nose (HP:0004122)	2.46000760
37	Aplasia/Hypoplasia of the patella (HP:0006498)	2.40906376
38	Restlessness (HP:0000711)	2.37061083
39	Hyperpituitarism (HP:0010514)	2.32241219
40	Progressive sensorineural hearing impairment (HP:0000408)	2.31284576
41	Shawl scrotum (HP:0000049)	2.30327955
42	Long toe (HP:0010511)	2.29642312
43	Focal seizures (HP:0007359)	2.28363265
44	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.26056470
45	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.26056470
46	Down-sloping shoulders (HP:0200021)	2.23790957
47	Lissencephaly (HP:0001339)	2.23668543
48	Hepatoblastoma (HP:0002884)	2.23056543
49	Absent septum pellucidum (HP:0001331)	2.19798381
50	Long foot (HP:0001833)	2.16841010
51	Small hand (HP:0200055)	2.16538993
52	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.15461038
53	Abnormality of the corticospinal tract (HP:0002492)	2.05838289
54	Growth hormone deficiency (HP:0000824)	2.04089663
55	Abnormality of the septum pellucidum (HP:0007375)	1.97901084
56	Labial hypoplasia (HP:0000066)	1.97855479
57	Thyroid-stimulating hormone excess (HP:0002925)	1.97044568
58	Nemaline bodies (HP:0003798)	1.96797669
59	Abnormality of the astrocytes (HP:0100707)	1.95637138
60	Astrocytoma (HP:0009592)	1.95637138
61	Myokymia (HP:0002411)	1.95263571
62	Tetraparesis (HP:0002273)	1.94916845
63	Retinal dysplasia (HP:0007973)	1.93969649
64	Narrow forehead (HP:0000341)	1.93740057
65	Dialeptic seizures (HP:0011146)	1.92877556
66	Genital tract atresia (HP:0001827)	1.90103169
67	Back pain (HP:0003418)	1.89455682
68	Abnormality of the lower motor neuron (HP:0002366)	1.86111050
69	Type II lissencephaly (HP:0007260)	1.84289504
70	Ependymoma (HP:0002888)	1.84226089
71	Vaginal atresia (HP:0000148)	1.83876200
72	Pallor (HP:0000980)	1.82496901
73	Precocious puberty (HP:0000826)	1.81857191
74	Meningocele (HP:0002435)	1.81448522
75	Abnormal eating behavior (HP:0100738)	1.81335304
76	Abnormality of the labia (HP:0000058)	1.81200592
77	Reticulocytopenia (HP:0001896)	1.80262759
78	Myelomeningocele (HP:0002475)	1.79345866
79	Bifid tongue (HP:0010297)	1.79183760
80	Specific learning disability (HP:0001328)	1.78677759
81	Sleep apnea (HP:0010535)	1.78664764
82	Hypoplastic female external genitalia (HP:0012815)	1.77961579
83	Absence seizures (HP:0002121)	1.76852583
84	Micropenis (HP:0000054)	1.73503842
85	Hip dysplasia (HP:0001385)	1.71837832
86	Febrile seizures (HP:0002373)	1.70627222
87	Hypomagnesemia (HP:0002917)	1.70423348
88	Gait imbalance (HP:0002141)	1.70054621
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.69598282
90	Decreased testicular size (HP:0008734)	1.67162486
91	Congenital malformation of the right heart (HP:0011723)	1.66795070
92	Double outlet right ventricle (HP:0001719)	1.66795070
93	Intestinal atresia (HP:0011100)	1.66603290
94	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.66588286
95	Epileptic encephalopathy (HP:0200134)	1.66577910
96	Bilateral microphthalmos (HP:0007633)	1.66306144
97	Truncal obesity (HP:0001956)	1.65445565
98	Glioma (HP:0009733)	1.64200826
99	Apathy (HP:0000741)	1.63109010
100	Progressive cerebellar ataxia (HP:0002073)	1.62937783

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	9.94015542
2	PKN2	4.07341559
3	LIMK1	3.74082530
4	CLK1	3.64578778
5	CASK	3.52282899
6	FLT3	2.22819996
7	ICK	2.02454045
8	NUAK1	1.92568590
9	DMPK	1.86554795
10	TAF1	1.81128150
11	BCR	1.63187849
12	WNK3	1.63165107
13	ERBB3	1.60585774
14	MARK1	1.55441053
15	ZAK	1.54928245
16	MAP3K4	1.49411275
17	TRIM28	1.48818172
18	WNK4	1.41669252
19	NTRK2	1.28916134
20	PDK2	1.28779728
21	TSSK6	1.27227463
22	MAP2K7	1.22917265
23	PAK6	1.22678747
24	TIE1	1.22411292
25	PAK3	1.20465713
26	TNIK	1.16821096
27	DYRK2	1.15464682
28	MARK2	1.12891929
29	MAPK13	1.11915495
30	BUB1	1.10483940
31	TAOK1	1.04330060
32	PNCK	1.00810909
33	NME1	1.00285602
34	MINK1	0.98774292
35	BMPR1B	0.96425357
36	ADRBK2	0.94818554
37	MAP3K9	0.94089667
38	CAMK1D	0.90611703
39	UHMK1	0.86547205
40	FGFR1	0.86368602
41	EPHB2	0.86321880
42	STK39	0.84525175
43	SIK3	0.82718464
44	PKN1	0.82537103
45	ROCK1	0.79820571
46	CAMK1	0.77116325
47	INSRR	0.69458779
48	TYRO3	0.64246876
49	PLK1	0.64211576
50	NTRK3	0.61258873
51	RAF1	0.60865132
52	CAMK1G	0.60594382
53	DYRK1B	0.55497403
54	NTRK1	0.55468308
55	MARK3	0.53739325
56	GRK5	0.53609012
57	GRK1	0.52204490
58	CAMK2G	0.51821963
59	MKNK2	0.49138613
60	CAMK2B	0.48478983
61	ILK	0.48232662
62	CAMK2D	0.47626144
63	CSNK1E	0.45257994
64	BMPR2	0.43337798
65	TRIB3	0.41898734
66	FER	0.40678324
67	PIM2	0.38896966
68	CSNK1D	0.37410909
69	RPS6KA2	0.36217597
70	VRK1	0.34773176
71	MAPK14	0.34403631
72	MAPK8	0.33212414
73	CSNK1G2	0.32966395
74	OXSR1	0.32935047
75	GSK3B	0.32923917
76	MAP2K4	0.30561899
77	ARAF	0.30478670
78	MUSK	0.30383290
79	CHEK1	0.29714669
80	RPS6KA3	0.28266075
81	PRKCE	0.27542114
82	CAMK2A	0.26727948
83	PRKCQ	0.25073540
84	PRKCG	0.24384449
85	PRKCI	0.23828039
86	PRKDC	0.23794559
87	CDK1	0.23209435
88	STK11	0.23086482
89	MAP2K2	0.22039910
90	CDK2	0.21934329
91	PRKCB	0.21403096
92	PRKG1	0.21178397
93	PLK3	0.20905314
94	SGK1	0.20883839
95	TAOK3	0.20512436
96	MAPK9	0.19951595
97	BRSK1	0.19595154
98	EIF2AK1	0.18417207
99	AURKA	0.18314006
100	RPS6KA6	0.16622530

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.22365262
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	6.15085563
3	Butanoate metabolism_Homo sapiens_hsa00650	3.89563207
4	Nicotine addiction_Homo sapiens_hsa05033	3.17955897
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.73568719
6	GABAergic synapse_Homo sapiens_hsa04727	2.24609503
7	Morphine addiction_Homo sapiens_hsa05032	2.08249303
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.91926629
9	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.86256867
10	Protein export_Homo sapiens_hsa03060	1.64951338
11	Glutamatergic synapse_Homo sapiens_hsa04724	1.58075271
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57710298
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.55137286
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49144953
15	Basal transcription factors_Homo sapiens_hsa03022	1.47330670
16	Axon guidance_Homo sapiens_hsa04360	1.46924892
17	Circadian entrainment_Homo sapiens_hsa04713	1.42843494
18	Phototransduction_Homo sapiens_hsa04744	1.42454202
19	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.40157671
20	Serotonergic synapse_Homo sapiens_hsa04726	1.39809058
21	Peroxisome_Homo sapiens_hsa04146	1.30443805
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30206624
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.21690293
24	Mismatch repair_Homo sapiens_hsa03430	1.20088882
25	Hippo signaling pathway_Homo sapiens_hsa04390	1.15469175
26	Cocaine addiction_Homo sapiens_hsa05030	1.15332361
27	Cholinergic synapse_Homo sapiens_hsa04725	1.11181062
28	Alcoholism_Homo sapiens_hsa05034	1.10957407
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.07978277
30	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.05569061
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.02694981
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02508787
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99029889
34	Oxidative phosphorylation_Homo sapiens_hsa00190	0.98236059
35	Prolactin signaling pathway_Homo sapiens_hsa04917	0.96526693
36	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.94218078
37	Wnt signaling pathway_Homo sapiens_hsa04310	0.92470270
38	Parkinsons disease_Homo sapiens_hsa05012	0.87916442
39	RNA transport_Homo sapiens_hsa03013	0.87592650
40	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84500544
41	Oocyte meiosis_Homo sapiens_hsa04114	0.79976355
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.76643040
43	Base excision repair_Homo sapiens_hsa03410	0.76226508
44	Homologous recombination_Homo sapiens_hsa03440	0.75017192
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.73689964
46	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.72429530
47	Tight junction_Homo sapiens_hsa04530	0.68722157
48	Taste transduction_Homo sapiens_hsa04742	0.68258443
49	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.66375984
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.64725582
51	Huntingtons disease_Homo sapiens_hsa05016	0.63670404
52	Colorectal cancer_Homo sapiens_hsa05210	0.60432124
53	Estrogen signaling pathway_Homo sapiens_hsa04915	0.59095646
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.59068358
55	Adherens junction_Homo sapiens_hsa04520	0.58179506
56	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.56907549
57	Melanogenesis_Homo sapiens_hsa04916	0.55549660
58	Vibrio cholerae infection_Homo sapiens_hsa05110	0.52578960
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.50040663
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46969990
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.46497474
62	RNA polymerase_Homo sapiens_hsa03020	0.46475596
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.46280492
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45090105
65	Spliceosome_Homo sapiens_hsa03040	0.44479343
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43109776
67	Insulin signaling pathway_Homo sapiens_hsa04910	0.42544065
68	Amphetamine addiction_Homo sapiens_hsa05031	0.42210047
69	Gap junction_Homo sapiens_hsa04540	0.42106914
70	Propanoate metabolism_Homo sapiens_hsa00640	0.41993762
71	Cell cycle_Homo sapiens_hsa04110	0.41887943
72	Ras signaling pathway_Homo sapiens_hsa04014	0.41859446
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.41166472
74	Alzheimers disease_Homo sapiens_hsa05010	0.41154302
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40235066
76	Endometrial cancer_Homo sapiens_hsa05213	0.39602334
77	Olfactory transduction_Homo sapiens_hsa04740	0.38926392
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38826223
79	Insulin secretion_Homo sapiens_hsa04911	0.38763874
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36412563
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35238140
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.35129875
83	DNA replication_Homo sapiens_hsa03030	0.34850449
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34165482
85	Gastric acid secretion_Homo sapiens_hsa04971	0.33569298
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33474696
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33235881
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33140184
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32954913
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32480743
91	Caffeine metabolism_Homo sapiens_hsa00232	0.32232042
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.31663618
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29672387
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28367754
95	Melanoma_Homo sapiens_hsa05218	0.28338751
96	Lysine degradation_Homo sapiens_hsa00310	0.26814537
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26459243
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26076843
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.25831089
100	Fatty acid degradation_Homo sapiens_hsa00071	0.24877167

PCDHA14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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