PCDHA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.92973419
2locomotory exploration behavior (GO:0035641)5.38250440
3neuron cell-cell adhesion (GO:0007158)5.21978731
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18191575
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08435467
6vocalization behavior (GO:0071625)5.06413607
7nucleobase catabolic process (GO:0046113)5.02519825
8synaptic vesicle exocytosis (GO:0016079)5.02313881
9layer formation in cerebral cortex (GO:0021819)4.96063684
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91296200
11protein localization to synapse (GO:0035418)4.74516970
12exploration behavior (GO:0035640)4.73039227
13regulation of glutamate receptor signaling pathway (GO:1900449)4.58268171
14synaptic vesicle maturation (GO:0016188)4.56543143
15regulation of synaptic vesicle exocytosis (GO:2000300)4.47159007
16presynaptic membrane organization (GO:0097090)4.45018726
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.43176494
18dendritic spine morphogenesis (GO:0060997)4.42699280
19negative regulation of microtubule polymerization (GO:0031115)4.35098574
20neuron recognition (GO:0008038)4.29127393
21glutamate secretion (GO:0014047)4.22993244
22limb bud formation (GO:0060174)3.97503121
23positive regulation of mitochondrial fission (GO:0090141)3.91563409
24dendrite morphogenesis (GO:0048813)3.89615477
25axonal fasciculation (GO:0007413)3.88857816
26cell migration in hindbrain (GO:0021535)3.86855453
27proline transport (GO:0015824)3.85865028
28regulation of synaptic vesicle transport (GO:1902803)3.82776528
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.81342653
30neurotransmitter secretion (GO:0007269)3.77593477
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77103303
32neurotransmitter-gated ion channel clustering (GO:0072578)3.76196502
33regulation of synapse structural plasticity (GO:0051823)3.68560342
34mating behavior (GO:0007617)3.66521704
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63663399
36calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.61348807
37retinal ganglion cell axon guidance (GO:0031290)3.60891698
38nonmotile primary cilium assembly (GO:0035058)3.59714286
39positive regulation of synapse maturation (GO:0090129)3.56337487
40glutamate receptor signaling pathway (GO:0007215)3.52761655
41regulation of neuronal synaptic plasticity (GO:0048168)3.52730340
42postsynaptic membrane organization (GO:0001941)3.50771792
43neuron-neuron synaptic transmission (GO:0007270)3.48814366
44central nervous system neuron axonogenesis (GO:0021955)3.48739272
45behavioral response to cocaine (GO:0048148)3.48540640
46clathrin coat assembly (GO:0048268)3.47912567
47mitochondrion transport along microtubule (GO:0047497)3.44192806
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.44192806
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43909307
50positive regulation of action potential (GO:0045760)3.43593832
51synapse assembly (GO:0007416)3.43287818
52central nervous system projection neuron axonogenesis (GO:0021952)3.39732274
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.38593055
54synaptic vesicle endocytosis (GO:0048488)3.37944101
55synaptic transmission, glutamatergic (GO:0035249)3.36430172
56establishment of mitochondrion localization (GO:0051654)3.34637672
57cerebellar Purkinje cell layer development (GO:0021680)3.30118339
58transmission of nerve impulse (GO:0019226)3.29623596
59response to pheromone (GO:0019236)3.28464620
60calcium ion-dependent exocytosis (GO:0017156)3.24385081
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24379387
62innervation (GO:0060384)3.22361125
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21681027
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19238242
65organelle transport along microtubule (GO:0072384)3.18519408
66activation of protein kinase A activity (GO:0034199)3.18316263
67neurotransmitter transport (GO:0006836)3.18057188
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15274395
69dopamine biosynthetic process (GO:0042416)3.13111656
70regulation of postsynaptic membrane potential (GO:0060078)3.12910757
71positive regulation of synapse assembly (GO:0051965)3.12664657
72presynaptic membrane assembly (GO:0097105)3.12341031
73response to auditory stimulus (GO:0010996)3.12307940
74neuronal action potential propagation (GO:0019227)3.12049401
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.10867285
76regulation of action potential (GO:0098900)3.09518658
77gamma-aminobutyric acid transport (GO:0015812)3.08769089
78long-term memory (GO:0007616)3.06782228
79ganglion development (GO:0061548)3.05878402
80synapse organization (GO:0050808)3.05677177
81head development (GO:0060322)3.04875652
82regulation of vesicle fusion (GO:0031338)3.02849630
83auditory behavior (GO:0031223)3.01007334
84positive regulation of membrane potential (GO:0045838)3.00344055
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99295803
86axon cargo transport (GO:0008088)2.99053510
87regulation of neurotransmitter secretion (GO:0046928)2.96844410
88establishment of synaptic vesicle localization (GO:0097480)2.96433172
89synaptic vesicle transport (GO:0048489)2.96433172
90positive regulation of neurotransmitter secretion (GO:0001956)2.94752102
91* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.92532350
92regulation of dendritic spine morphogenesis (GO:0061001)2.92291639
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92201386
94axon extension (GO:0048675)2.91926400
95regulation of neurotransmitter levels (GO:0001505)2.91844868
96regulation of cilium movement (GO:0003352)2.91806367
97prepulse inhibition (GO:0060134)2.91219436
98cerebral cortex radially oriented cell migration (GO:0021799)2.90980887
99long-term synaptic potentiation (GO:0060291)2.90046255
100vesicle transport along microtubule (GO:0047496)2.88659399
101synaptic transmission, dopaminergic (GO:0001963)2.88176167
102regulation of cAMP-dependent protein kinase activity (GO:2000479)2.86943322
103hippocampus development (GO:0021766)2.86631373
104response to histamine (GO:0034776)2.86092519
105membrane depolarization during action potential (GO:0086010)2.85988010
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.85868381
107positive regulation of neurotransmitter transport (GO:0051590)2.85576137
108regulation of respiratory system process (GO:0044065)2.85165148
109glycosphingolipid biosynthetic process (GO:0006688)2.85080933
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.85027291
111social behavior (GO:0035176)2.84613519
112intraspecies interaction between organisms (GO:0051703)2.84613519
113membrane depolarization (GO:0051899)2.83760933
114regulation of development, heterochronic (GO:0040034)2.83555650
115cellular potassium ion homeostasis (GO:0030007)2.83112479
116membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83039224
117detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.82222321
118detection of temperature stimulus involved in sensory perception (GO:0050961)2.82222321
119learning (GO:0007612)2.82097231
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81293635
121membrane hyperpolarization (GO:0060081)2.81149290
122establishment of vesicle localization (GO:0051650)2.79681565
123regulation of synaptic plasticity (GO:0048167)2.76698173
124glial cell proliferation (GO:0014009)2.75433571
125mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.73167837
126positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.73167837
127sequestering of actin monomers (GO:0042989)2.73143875
128startle response (GO:0001964)2.69909245
129dendritic spine organization (GO:0097061)2.68707296
130mechanosensory behavior (GO:0007638)2.66586376
131intraciliary transport (GO:0042073)2.66529245
132L-fucose metabolic process (GO:0042354)2.66138063
133L-fucose catabolic process (GO:0042355)2.66138063
134fucose catabolic process (GO:0019317)2.66138063
135neuron migration (GO:0001764)2.66092387
136glycerophospholipid catabolic process (GO:0046475)2.64304763
137forebrain neuron differentiation (GO:0021879)2.63706234
138axonogenesis (GO:0007409)2.63472267
139neuronal stem cell maintenance (GO:0097150)2.60304577
140behavioral response to nicotine (GO:0035095)2.59181864
141negative regulation of oligodendrocyte differentiation (GO:0048715)2.59114384
142neural tube formation (GO:0001841)2.59053352
143regulation of synapse assembly (GO:0051963)2.55207622
144epithelial cilium movement (GO:0003351)2.53814282
145retinal rod cell development (GO:0046548)2.51556908
146regulation of mitochondrial fission (GO:0090140)2.51328410
147negative regulation of axon guidance (GO:1902668)2.50522568
148cholesterol biosynthetic process (GO:0006695)2.50371425
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48479002
150response to dietary excess (GO:0002021)2.48072818
151spinal cord development (GO:0021510)2.45805091
152cerebral cortex cell migration (GO:0021795)2.45248395
153axon extension involved in axon guidance (GO:0048846)2.45238036
154neuron projection extension involved in neuron projection guidance (GO:1902284)2.45238036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.48745170
2GBX2_23144817_ChIP-Seq_PC3_Human3.49958606
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94357769
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77851867
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.76570429
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74824304
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67999135
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56574245
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.51946393
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36101993
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28211830
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28211830
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26934197
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26576887
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26143113
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25534391
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23734507
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19764283
19ZNF274_21170338_ChIP-Seq_K562_Hela2.19356621
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.18949962
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15613531
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14093400
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.13916375
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12785942
25DROSHA_22980978_ChIP-Seq_HELA_Human2.11605972
26TAF15_26573619_Chip-Seq_HEK293_Human2.07354782
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06819659
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05312014
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.99316793
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.96982610
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96610552
32AR_21572438_ChIP-Seq_LNCaP_Human1.94351453
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93197841
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.91458761
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86302280
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81694467
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69220748
38SMAD4_21799915_ChIP-Seq_A2780_Human1.66986330
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.61674184
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58647841
41VDR_22108803_ChIP-Seq_LS180_Human1.54028730
42P300_19829295_ChIP-Seq_ESCs_Human1.52443588
43RNF2_27304074_Chip-Seq_NSC_Mouse1.48570809
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47168184
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46486924
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45192801
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42946927
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42449948
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41053765
50EWS_26573619_Chip-Seq_HEK293_Human1.39818152
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.38895441
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37115518
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35153499
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.34888496
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.34478578
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32832627
57AR_25329375_ChIP-Seq_VCAP_Human1.30559284
58FUS_26573619_Chip-Seq_HEK293_Human1.27726216
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26072642
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25843433
61* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25711422
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.25426744
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25123023
64* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24838064
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23913203
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23751862
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23751862
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21843110
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21653518
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.19078091
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18876279
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18653712
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18121873
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16831713
75STAT3_23295773_ChIP-Seq_U87_Human1.16369731
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15535235
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.15207960
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.13381557
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.12941220
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12677450
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12654605
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.12631343
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09017023
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08965598
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08521872
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08122721
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07931765
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.07725377
89TCF4_23295773_ChIP-Seq_U87_Human1.07717489
90AR_19668381_ChIP-Seq_PC3_Human1.07706409
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07130041
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05602124
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05182738
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04094335
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03103506
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03070054
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.01371012
98SOX2_16153702_ChIP-ChIP_HESCs_Human1.00775496
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00486945
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00444430
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00305326
102RUNX2_22187159_ChIP-Seq_PCA_Human1.00240532
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.00168398
104PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99682455
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99428930
106CBP_20019798_ChIP-Seq_JUKART_Human0.98628746
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98628746
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98539048
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.98119911
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97709588
111SOX9_26525672_Chip-Seq_HEART_Mouse0.97625005
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96484437
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.96288407
114ER_23166858_ChIP-Seq_MCF-7_Human0.96064220
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95789451
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.95315404
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95252856
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94989451
119JUN_21703547_ChIP-Seq_K562_Human0.94898164
120* KDM2B_26808549_Chip-Seq_REH_Human0.94055061
121BCAT_22108803_ChIP-Seq_LS180_Human0.94007000
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93942250
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93887706
124IGF1R_20145208_ChIP-Seq_DFB_Human0.92735798
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89937849
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88682398
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.88341293
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87653365
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.86590207
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85976609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90294467
2MP0003880_abnormal_central_pattern4.29043022
3MP0003635_abnormal_synaptic_transmissio3.79351489
4MP0004270_analgesia3.72320736
5MP0002063_abnormal_learning/memory/cond3.19062671
6MP0005423_abnormal_somatic_nervous3.17576708
7MP0009745_abnormal_behavioral_response2.98018345
8MP0001968_abnormal_touch/_nociception2.83409054
9MP0002734_abnormal_mechanical_nocicepti2.78656696
10MP0002572_abnormal_emotion/affect_behav2.71978015
11MP0002064_seizures2.70691440
12MP0006276_abnormal_autonomic_nervous2.57923586
13MP0009046_muscle_twitch2.50192534
14MP0000778_abnormal_nervous_system2.47474315
15MP0001440_abnormal_grooming_behavior2.40009218
16MP0002735_abnormal_chemical_nociception2.38132137
17MP0002822_catalepsy2.36206090
18MP0001486_abnormal_startle_reflex2.33380614
19MP0002733_abnormal_thermal_nociception2.32059341
20MP0005410_abnormal_fertilization2.27358683
21MP0002184_abnormal_innervation2.26402123
22MP0002736_abnormal_nociception_after2.26228652
23MP0002272_abnormal_nervous_system2.12711709
24MP0003329_amyloid_beta_deposits2.08127062
25MP0003121_genomic_imprinting2.03950231
26MP0002909_abnormal_adrenal_gland2.01534496
27MP0002067_abnormal_sensory_capabilities2.01463498
28MP0001970_abnormal_pain_threshold2.00732406
29MP0005386_behavior/neurological_phenoty1.91057492
30MP0004924_abnormal_behavior1.91057492
31MP0001529_abnormal_vocalization1.85806617
32MP0002557_abnormal_social/conspecific_i1.79425293
33MP0004811_abnormal_neuron_physiology1.78278677
34MP0003879_abnormal_hair_cell1.77469686
35MP0003122_maternal_imprinting1.75288651
36MP0004858_abnormal_nervous_system1.74395991
37MP0001501_abnormal_sleep_pattern1.70338643
38MP0001984_abnormal_olfaction1.69729829
39MP0000955_abnormal_spinal_cord1.69300741
40MP0002653_abnormal_ependyma_morphology1.68512794
41MP0000569_abnormal_digit_pigmentation1.61633564
42MP0004133_heterotaxia1.60235922
43MP0001905_abnormal_dopamine_level1.59307211
44MP0005248_abnormal_Harderian_gland1.58443059
45MP0009780_abnormal_chondrocyte_physiolo1.57060140
46MP0002638_abnormal_pupillary_reflex1.55662705
47MP0002882_abnormal_neuron_morphology1.55546996
48MP0008569_lethality_at_weaning1.48514672
49MP0001188_hyperpigmentation1.43802314
50MP0002066_abnormal_motor_capabilities/c1.43260261
51MP0003136_yellow_coat_color1.43221315
52MP0005645_abnormal_hypothalamus_physiol1.42865731
53MP0000049_abnormal_middle_ear1.36150739
54MP0000516_abnormal_urinary_system1.31036926
55MP0005367_renal/urinary_system_phenotyp1.31036926
56MP0003119_abnormal_digestive_system1.28494974
57MP0002152_abnormal_brain_morphology1.27819216
58MP0005551_abnormal_eye_electrophysiolog1.25116120
59MP0004885_abnormal_endolymph1.24848476
60MP0005187_abnormal_penis_morphology1.22662762
61MP0005171_absent_coat_pigmentation1.17494539
62MP0003787_abnormal_imprinting1.15574367
63MP0001502_abnormal_circadian_rhythm1.15508780
64MP0000751_myopathy1.15032180
65MP0003890_abnormal_embryonic-extraembry1.14812858
66MP0002938_white_spotting1.13563080
67MP0000631_abnormal_neuroendocrine_gland1.13000330
68MP0005646_abnormal_pituitary_gland1.12416551
69MP0001299_abnormal_eye_distance/1.09725726
70MP0004742_abnormal_vestibular_system1.04947569
71MP0001293_anophthalmia1.04030313
72MP0003633_abnormal_nervous_system1.03853720
73MP0002229_neurodegeneration1.03497644
74MP0008877_abnormal_DNA_methylation1.03459715
75MP0003221_abnormal_cardiomyocyte_apopto1.03176093
76MP0005394_taste/olfaction_phenotype1.01221846
77MP0005499_abnormal_olfactory_system1.01221846
78MP0003385_abnormal_body_wall1.00948837
79MP0003698_abnormal_male_reproductive1.00933878
80MP0009379_abnormal_foot_pigmentation0.99679501
81MP0002234_abnormal_pharynx_morphology0.99144689
82MP0002752_abnormal_somatic_nervous0.99135176
83MP0003631_nervous_system_phenotype0.98899788
84MP0002233_abnormal_nose_morphology0.98366978
85MP0000604_amyloidosis0.96778433
86MP0002090_abnormal_vision0.96005851
87MP0003634_abnormal_glial_cell0.95492164
88MP0004142_abnormal_muscle_tone0.94802560
89MP0002837_dystrophic_cardiac_calcinosis0.94752323
90MP0002069_abnormal_eating/drinking_beha0.94132933
91MP0003937_abnormal_limbs/digits/tail_de0.94029850
92MP0000647_abnormal_sebaceous_gland0.92871231
93MP0006072_abnormal_retinal_apoptosis0.91980339
94MP0003011_delayed_dark_adaptation0.90107537
95MP0001963_abnormal_hearing_physiology0.89231574
96MP0004085_abnormal_heartbeat0.88663867
97MP0005391_vision/eye_phenotype0.86484378
98MP0000534_abnormal_ureter_morphology0.85467313
99MP0003861_abnormal_nervous_system0.84537179
100MP0003632_abnormal_nervous_system0.84271739
101MP0003755_abnormal_palate_morphology0.84261989
102MP0010386_abnormal_urinary_bladder0.83632085
103MP0005535_abnormal_body_temperature0.82538498
104MP0002102_abnormal_ear_morphology0.81366977
105MP0004145_abnormal_muscle_electrophysio0.81081900
106MP0006292_abnormal_olfactory_placode0.78806703
107MP0001348_abnormal_lacrimal_gland0.78440348
108MP0000537_abnormal_urethra_morphology0.77654834
109MP0005409_darkened_coat_color0.76624959
110MP0008872_abnormal_physiological_respon0.76200489
111MP0002081_perinatal_lethality0.73465415
112MP0008789_abnormal_olfactory_epithelium0.72622676
113MP0005623_abnormal_meninges_morphology0.72471470
114MP0001177_atelectasis0.72229036
115MP0001485_abnormal_pinna_reflex0.71484490
116MP0003137_abnormal_impulse_conducting0.70952618
117MP0002751_abnormal_autonomic_nervous0.70946250
118MP0002928_abnormal_bile_duct0.69097157
119MP0003283_abnormal_digestive_organ0.68446703
120MP0001286_abnormal_eye_development0.67241439
121MP0003567_abnormal_fetal_cardiomyocyte0.66774980
122MP0009053_abnormal_anal_canal0.66203883
123MP0002254_reproductive_system_inflammat0.65929051
124MP0000026_abnormal_inner_ear0.64600328
125MP0008874_decreased_physiological_sensi0.61755902
126MP0002876_abnormal_thyroid_physiology0.60455540
127MP0005195_abnormal_posterior_eye0.59417474
128MP0001943_abnormal_respiration0.59386735
129MP0005253_abnormal_eye_physiology0.59103358
130MP0003172_abnormal_lysosome_physiology0.58467664
131MP0002161_abnormal_fertility/fecundity0.58241698
132MP0008961_abnormal_basal_metabolism0.56608862
133MP0010770_preweaning_lethality0.56297581
134MP0002082_postnatal_lethality0.56297581

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)6.49847663
2Focal motor seizures (HP:0011153)6.20956286
3Myokymia (HP:0002411)5.40777465
4Focal seizures (HP:0007359)5.31371116
5Limb dystonia (HP:0002451)4.46197039
6Absence seizures (HP:0002121)4.21843529
7Mutism (HP:0002300)4.01205717
8Progressive cerebellar ataxia (HP:0002073)3.95096243
9Cerebral inclusion bodies (HP:0100314)3.76614088
10Hepatoblastoma (HP:0002884)3.75083599
11Epileptic encephalopathy (HP:0200134)3.67917082
12Amyotrophic lateral sclerosis (HP:0007354)3.67716839
13Dialeptic seizures (HP:0011146)3.63148258
14Supranuclear gaze palsy (HP:0000605)3.49677033
15Congenital primary aphakia (HP:0007707)3.45457862
16Atonic seizures (HP:0010819)3.36153550
17Medial flaring of the eyebrow (HP:0010747)3.35167364
18Polyphagia (HP:0002591)3.31767662
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.29025887
20Absent/shortened dynein arms (HP:0200106)3.29025887
21Nephrogenic diabetes insipidus (HP:0009806)3.20314244
22Generalized tonic-clonic seizures (HP:0002069)3.18064321
23Ankle clonus (HP:0011448)3.18047005
24Neurofibrillary tangles (HP:0002185)3.14155602
25Drooling (HP:0002307)3.13345751
26Excessive salivation (HP:0003781)3.13345751
27Febrile seizures (HP:0002373)3.06856726
28Pheochromocytoma (HP:0002666)3.04447676
29Action tremor (HP:0002345)3.02024521
30Abnormality of the corticospinal tract (HP:0002492)3.00444074
31Akinesia (HP:0002304)2.99882899
32Genital tract atresia (HP:0001827)2.98100238
33Papilledema (HP:0001085)2.97940407
34Vaginal atresia (HP:0000148)2.97312375
35Broad-based gait (HP:0002136)2.94492102
36Abnormality of the labia minora (HP:0012880)2.92696643
37Insidious onset (HP:0003587)2.85778256
38Termporal pattern (HP:0011008)2.85778256
39Hyperventilation (HP:0002883)2.85261202
40Torticollis (HP:0000473)2.84800909
41Hypoplasia of the brainstem (HP:0002365)2.77339456
42Aplasia/Hypoplasia of the brainstem (HP:0007362)2.77339456
43Amblyopia (HP:0000646)2.70494148
44Abnormal eating behavior (HP:0100738)2.70244838
45Alacrima (HP:0000522)2.68415785
46Agitation (HP:0000713)2.66642995
47Truncal ataxia (HP:0002078)2.65396311
48Depression (HP:0000716)2.63148096
49Epileptiform EEG discharges (HP:0011182)2.62693473
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.60958810
51Vitreoretinal degeneration (HP:0000655)2.59855109
52EEG with generalized epileptiform discharges (HP:0011198)2.58928048
53Decreased lacrimation (HP:0000633)2.56758110
54Progressive inability to walk (HP:0002505)2.55819526
55Neuroendocrine neoplasm (HP:0100634)2.55574991
56Spastic gait (HP:0002064)2.54533027
57Urinary urgency (HP:0000012)2.52332380
58Morphological abnormality of the pyramidal tract (HP:0002062)2.51763096
59Anxiety (HP:0000739)2.50041615
60Chorioretinal atrophy (HP:0000533)2.49122214
61Hypsarrhythmia (HP:0002521)2.48446895
62Abnormal respiratory epithelium morphology (HP:0012253)2.47238374
63Abnormal respiratory motile cilium morphology (HP:0005938)2.47238374
64Urinary bladder sphincter dysfunction (HP:0002839)2.46992019
65Broad foot (HP:0001769)2.45177304
66Focal dystonia (HP:0004373)2.42939865
67Occipital encephalocele (HP:0002085)2.41952725
68Pancreatic fibrosis (HP:0100732)2.41596456
69Fetal akinesia sequence (HP:0001989)2.39914242
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39833693
71Poor coordination (HP:0002370)2.38769866
72Poor eye contact (HP:0000817)2.38707688
73Lissencephaly (HP:0001339)2.38609234
74Craniofacial dystonia (HP:0012179)2.38133175
75Gait imbalance (HP:0002141)2.37018076
76Abnormality of the lower motor neuron (HP:0002366)2.35798000
77Impaired vibration sensation in the lower limbs (HP:0002166)2.35676764
78Esotropia (HP:0000565)2.32719647
79Pancreatic cysts (HP:0001737)2.32558447
80Abnormal respiratory motile cilium physiology (HP:0012261)2.32536932
81True hermaphroditism (HP:0010459)2.30899235
82Postaxial hand polydactyly (HP:0001162)2.28630902
83Long clavicles (HP:0000890)2.28135325
84Hyperglycinemia (HP:0002154)2.26236004
85Hemiparesis (HP:0001269)2.25940974
86Abnormality of the pubic bones (HP:0003172)2.25739574
87Inability to walk (HP:0002540)2.24361744
88Impaired social interactions (HP:0000735)2.21883737
89Abnormal social behavior (HP:0012433)2.21883737
90Abnormality of the metopic suture (HP:0005556)2.18766184
91Intestinal atresia (HP:0011100)2.18727150
92Chronic hepatic failure (HP:0100626)2.18680163
93Atrophy/Degeneration involving motor neurons (HP:0007373)2.15512726
94Lower limb muscle weakness (HP:0007340)2.15007337
95Genetic anticipation (HP:0003743)2.14792735
96Inappropriate behavior (HP:0000719)2.14677260
97Dysdiadochokinesis (HP:0002075)2.13504764
98Stereotypic behavior (HP:0000733)2.12553811
99Gaze-evoked nystagmus (HP:0000640)2.11572783
100Diplopia (HP:0000651)2.10864190
101Abnormality of binocular vision (HP:0011514)2.10864190
102Renal hypoplasia (HP:0000089)2.10361444
103Short foot (HP:0001773)2.10016015
104Abnormal ciliary motility (HP:0012262)2.09701923
105Papillary thyroid carcinoma (HP:0002895)2.08627764
106Delusions (HP:0000746)2.08562280
107Aplasia/Hypoplasia of the sternum (HP:0006714)2.08179242
108Abnormality of salivation (HP:0100755)2.07289610
109Intention tremor (HP:0002080)2.06702412
110Narrow forehead (HP:0000341)2.05789069
111Failure to thrive in infancy (HP:0001531)2.03626578
112Nephronophthisis (HP:0000090)2.01688045
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00861413
114Dysmetria (HP:0001310)1.99563928
115Bradykinesia (HP:0002067)1.99465482
116Postural instability (HP:0002172)1.99041263
117Abnormality of the hip-girdle musculature (HP:0001445)1.97195392
118Abnormality of the musculature of the pelvis (HP:0001469)1.97195392
119Decreased testicular size (HP:0008734)1.96905833
120Rapidly progressive (HP:0003678)1.96654873
121Hypoventilation (HP:0002791)1.96215911
122Apathy (HP:0000741)1.96161015
123Aqueductal stenosis (HP:0002410)1.96124694
124Infertility (HP:0000789)1.93372768
125Clonus (HP:0002169)1.92855779
126Rhinitis (HP:0012384)1.91887732
127Abnormality of midbrain morphology (HP:0002418)1.91321906
128Molar tooth sign on MRI (HP:0002419)1.91321906
129Increased serum pyruvate (HP:0003542)1.90612254
130Abnormality of glycolysis (HP:0004366)1.90612254
131Pachygyria (HP:0001302)1.90165219
132Psychosis (HP:0000709)1.89119934
133Abnormality of the astrocytes (HP:0100707)1.88061292
134Astrocytoma (HP:0009592)1.88061292
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86621218
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.86621218
137Abnormality of the renal medulla (HP:0100957)1.85576372
138Shoulder girdle muscle weakness (HP:0003547)1.84820358
139Abnormality of the anterior horn cell (HP:0006802)1.83404628
140Degeneration of anterior horn cells (HP:0002398)1.83404628
141Thyroid carcinoma (HP:0002890)1.83360922
142Retinal dysplasia (HP:0007973)1.82811786
143Neoplasm of the peripheral nervous system (HP:0100007)1.82295153
144Poor suck (HP:0002033)1.82288535
145Micropenis (HP:0000054)1.82160906
146Cortical dysplasia (HP:0002539)1.82003814
147Specific learning disability (HP:0001328)1.81993364
148Hypothermia (HP:0002045)1.81652936
149Hypoplasia of the corpus callosum (HP:0002079)1.78149557
150Aplasia/Hypoplasia of the lens (HP:0008063)1.75561586
151Curly hair (HP:0002212)1.74962053
152Increased density of long bones (HP:0006392)1.74885345
153Ulnar claw (HP:0001178)1.74062027
154Postaxial foot polydactyly (HP:0001830)1.72490683
155Spastic tetraplegia (HP:0002510)1.72454935
156Hypoplastic pelvis (HP:0008839)1.72029327
157Anterior segment dysgenesis (HP:0007700)1.66875936
158Cystic liver disease (HP:0006706)1.66579500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.18074574
2TRIM283.76800557
3NTRK33.27607749
4MAP3K92.95125985
5MINK12.88618155
6MAP3K42.82641387
7NTRK22.54521690
8CASK2.34542799
9SIK22.19256098
10MAP2K72.18368237
11MAP4K22.18348953
12PINK12.15242772
13PAK62.14702025
14MAPK132.05237975
15MAP3K122.02088448
16PHKG22.00351184
17PHKG12.00351184
18DYRK21.84477509
19MAP2K41.77152801
20PNCK1.76529368
21DAPK21.74409212
22GRK51.73129375
23LATS21.72968056
24PLK21.69429821
25BMPR1B1.62689261
26EPHA41.61513988
27FRK1.61407732
28BCKDK1.59169721
29NTRK11.56357329
30PRKD31.56327257
31CDK51.49355406
32KSR11.47650081
33KSR21.37903793
34PDK31.37392381
35PDK41.37392381
36UHMK11.37044298
37ERBB31.34432741
38EPHA31.29391165
39CSNK1G21.28592804
40INSRR1.27033620
41PAK31.17673426
42TYRO31.15389084
43DYRK1B1.12914464
44PRKCG1.11363160
45PTK2B1.11020163
46DYRK31.09964398
47CAMKK11.08770287
48CDK181.08416356
49CDK141.08032441
50CDK151.04761317
51CAMK2A1.01013178
52STK161.00526799
53TESK11.00199401
54DYRK1A0.99160395
55MAP3K60.95881971
56CDK11A0.94262555
57MARK20.94105755
58DAPK10.92635678
59RPS6KA40.91358670
60CSNK1G30.89879177
61STK390.88866528
62BCR0.88800763
63PKN10.86676115
64TNIK0.84810241
65WNK40.82604056
66MAP3K20.82588052
67GRK10.81997795
68FGFR20.81756873
69FGR0.80647658
70SRPK10.78731257
71RET0.78628522
72CDK190.74727643
73PRPF4B0.74044702
74CAMK2B0.72597469
75ADRBK20.70173055
76SIK30.69670865
77MAP3K50.69109972
78RPS6KA20.68903250
79PRKCZ0.68545736
80ICK0.67816280
81WNK30.66461483
82STK110.65772278
83SCYL20.62522302
84BRD40.62074532
85ACVR1B0.61871304
86FES0.59811129
87STK380.59622349
88TAOK10.54430951
89CSNK1G10.53364141
90GRK60.53303698
91CSNK1A1L0.52868599
92PRKCE0.52800486
93FYN0.52360155
94PDK20.51764279
95ERBB20.50328610
96SGK2230.48909833
97SGK4940.48909833
98ADRBK10.46247209
99SGK20.45959642
100MAPK120.45902479
101PRKAA10.45868419
102LMTK20.45350367
103ARAF0.45117617
104RIPK40.44979073
105TIE10.44759857
106CSNK1D0.44713525
107FER0.43124752
108ALK0.42130298
109CSNK1A10.41831229
110MAPKAPK50.41630486
111AKT30.41595363
112LIMK10.41428641
113EPHB10.39937343
114CAMK2D0.38794628
115PRKCH0.38444206
116RIPK10.38267468
117STK38L0.38233665
118RPS6KA30.37977433
119PRKACB0.37596750
120PIM20.35709799
121WNK10.35494416
122NME10.34302744
123NUAK10.34219532
124MAPK90.33687776
125CAMKK20.33384474
126CSNK1E0.33129174
127EPHB20.33123266
128CAMK10.32942079
129CDK30.32723195
130MAP2K60.32710281
131SGK10.32356834
132PRKACA0.32349258
133MAP2K10.32185611
134MKNK10.32016343
135OXSR10.30792095
136TGFBR10.29827245
137TLK10.27024808
138MKNK20.24230537
139LATS10.23363390
140PRKG10.22465853
141SRC0.21874089
142YES10.21514040
143PRKCB0.20431195

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52702438
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30478859
3Steroid biosynthesis_Homo sapiens_hsa001002.87411274
4GABAergic synapse_Homo sapiens_hsa047272.51264189
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48443817
6Circadian entrainment_Homo sapiens_hsa047132.47653152
7Long-term potentiation_Homo sapiens_hsa047202.47551757
8Amphetamine addiction_Homo sapiens_hsa050312.46649884
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39406519
10Dopaminergic synapse_Homo sapiens_hsa047282.38632027
11Glutamatergic synapse_Homo sapiens_hsa047242.33834893
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33798400
13Morphine addiction_Homo sapiens_hsa050322.23012346
14Olfactory transduction_Homo sapiens_hsa047402.18386416
15Protein export_Homo sapiens_hsa030602.05369131
16Cocaine addiction_Homo sapiens_hsa050302.03566946
17Insulin secretion_Homo sapiens_hsa049112.02071498
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91118323
19Cholinergic synapse_Homo sapiens_hsa047251.87430212
20Salivary secretion_Homo sapiens_hsa049701.84839173
21Serotonergic synapse_Homo sapiens_hsa047261.83292759
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82954912
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80191265
24Renin secretion_Homo sapiens_hsa049241.77495374
25Propanoate metabolism_Homo sapiens_hsa006401.76057806
26Axon guidance_Homo sapiens_hsa043601.72240401
27Long-term depression_Homo sapiens_hsa047301.68809318
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64397792
29Gastric acid secretion_Homo sapiens_hsa049711.60798166
30Collecting duct acid secretion_Homo sapiens_hsa049661.60521236
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56760095
32Gap junction_Homo sapiens_hsa045401.55666086
33Taste transduction_Homo sapiens_hsa047421.55096512
34Oxytocin signaling pathway_Homo sapiens_hsa049211.48179383
35Cardiac muscle contraction_Homo sapiens_hsa042601.44696051
36Calcium signaling pathway_Homo sapiens_hsa040201.37432287
37GnRH signaling pathway_Homo sapiens_hsa049121.31971824
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30854804
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27418730
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23220754
41Vibrio cholerae infection_Homo sapiens_hsa051101.23119173
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22105127
43Estrogen signaling pathway_Homo sapiens_hsa049151.21447962
44Hedgehog signaling pathway_Homo sapiens_hsa043401.15579103
45Oocyte meiosis_Homo sapiens_hsa041141.15414716
46Hippo signaling pathway_Homo sapiens_hsa043901.11640048
47Phototransduction_Homo sapiens_hsa047441.10475535
48Basal cell carcinoma_Homo sapiens_hsa052171.09337326
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07969105
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07663952
51Type II diabetes mellitus_Homo sapiens_hsa049301.07519851
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06456769
53Alzheimers disease_Homo sapiens_hsa050101.05690610
54Dorso-ventral axis formation_Homo sapiens_hsa043201.04211366
55ErbB signaling pathway_Homo sapiens_hsa040121.02075251
56Fatty acid metabolism_Homo sapiens_hsa012121.01636131
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01424684
58cAMP signaling pathway_Homo sapiens_hsa040241.00578900
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97740845
60Glioma_Homo sapiens_hsa052140.97510114
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96968870
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94277990
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92141144
64Fatty acid elongation_Homo sapiens_hsa000620.91496149
65Oxidative phosphorylation_Homo sapiens_hsa001900.90338206
66Parkinsons disease_Homo sapiens_hsa050120.89558091
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89539612
68Selenocompound metabolism_Homo sapiens_hsa004500.88213038
69Melanogenesis_Homo sapiens_hsa049160.88208504
70Alcoholism_Homo sapiens_hsa050340.83913099
71beta-Alanine metabolism_Homo sapiens_hsa004100.82673594
72Basal transcription factors_Homo sapiens_hsa030220.82425023
73mRNA surveillance pathway_Homo sapiens_hsa030150.82379886
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80994936
75Glucagon signaling pathway_Homo sapiens_hsa049220.80024865
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79085468
77Ether lipid metabolism_Homo sapiens_hsa005650.78848243
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78391582
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77660194
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.75662159
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75637317
82Peroxisome_Homo sapiens_hsa041460.75493091
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74410208
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73967204
85Tight junction_Homo sapiens_hsa045300.73898140
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71748310
87MAPK signaling pathway_Homo sapiens_hsa040100.70995944
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70600794
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.69625029
90Thyroid hormone synthesis_Homo sapiens_hsa049180.69121345
91Caffeine metabolism_Homo sapiens_hsa002320.68913256
92Butanoate metabolism_Homo sapiens_hsa006500.68807733
93Linoleic acid metabolism_Homo sapiens_hsa005910.68505362
94Pancreatic secretion_Homo sapiens_hsa049720.67272716
95Circadian rhythm_Homo sapiens_hsa047100.64977974
96Huntingtons disease_Homo sapiens_hsa050160.64704952
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64449989
98Dilated cardiomyopathy_Homo sapiens_hsa054140.64171443
99Pyruvate metabolism_Homo sapiens_hsa006200.63821617
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62250338
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.61481871
102Tryptophan metabolism_Homo sapiens_hsa003800.61211862
103VEGF signaling pathway_Homo sapiens_hsa043700.61063608
104AMPK signaling pathway_Homo sapiens_hsa041520.59964546
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.59098781
106Renal cell carcinoma_Homo sapiens_hsa052110.58671386
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57799571
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56824931
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54416397
110Lysine degradation_Homo sapiens_hsa003100.54385859
111ABC transporters_Homo sapiens_hsa020100.53165368
112Endometrial cancer_Homo sapiens_hsa052130.53042807
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51914087
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51394176
115Adherens junction_Homo sapiens_hsa045200.50030222
116Prion diseases_Homo sapiens_hsa050200.49808479
117mTOR signaling pathway_Homo sapiens_hsa041500.49295891
118Choline metabolism in cancer_Homo sapiens_hsa052310.48980367
119Ras signaling pathway_Homo sapiens_hsa040140.48950576
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.48057490
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45631621
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44150377
123Endocytosis_Homo sapiens_hsa041440.43762167
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43029731
125Insulin signaling pathway_Homo sapiens_hsa049100.42593438
126Bile secretion_Homo sapiens_hsa049760.41641706
127Colorectal cancer_Homo sapiens_hsa052100.39404140
128Phagosome_Homo sapiens_hsa041450.37790839
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37260032
130Rap1 signaling pathway_Homo sapiens_hsa040150.36633492
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36580502
132Wnt signaling pathway_Homo sapiens_hsa043100.36154051
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.35562373
134Fatty acid biosynthesis_Homo sapiens_hsa000610.33438999
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31477505
136Spliceosome_Homo sapiens_hsa030400.30994512
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30648891
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30571954
139Ovarian steroidogenesis_Homo sapiens_hsa049130.30032084
140Metabolic pathways_Homo sapiens_hsa011000.29867215
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27974847
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26578355
143Inositol phosphate metabolism_Homo sapiens_hsa005620.26254494

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