PCDHA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49564077
2protein localization to synapse (GO:0035418)5.46437933
3vocalization behavior (GO:0071625)5.41736505
4synaptic vesicle exocytosis (GO:0016079)5.38871648
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.34893476
6neuron cell-cell adhesion (GO:0007158)5.20151377
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.13843135
8synaptic vesicle maturation (GO:0016188)5.10982700
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03521443
10glutamate secretion (GO:0014047)5.02142958
11regulation of synaptic vesicle exocytosis (GO:2000300)4.90750802
12locomotory exploration behavior (GO:0035641)4.85592015
13layer formation in cerebral cortex (GO:0021819)4.78527612
14pyrimidine nucleobase catabolic process (GO:0006208)4.74381017
15regulation of glutamate receptor signaling pathway (GO:1900449)4.70623321
16proline transport (GO:0015824)4.65735680
17negative regulation of microtubule polymerization (GO:0031115)4.41433503
18exploration behavior (GO:0035640)4.40662006
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.33400593
20neurotransmitter secretion (GO:0007269)4.31458361
21regulation of synaptic vesicle transport (GO:1902803)4.22771981
22nucleobase catabolic process (GO:0046113)4.14428828
23calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.11538730
24neuron recognition (GO:0008038)4.10999763
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.04343825
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03266010
27regulation of synapse structural plasticity (GO:0051823)4.00463037
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96793769
29cell migration in hindbrain (GO:0021535)3.95212120
30glutamate receptor signaling pathway (GO:0007215)3.82480594
31regulation of neuronal synaptic plasticity (GO:0048168)3.78289979
32postsynaptic membrane organization (GO:0001941)3.75887834
33synaptic transmission, glutamatergic (GO:0035249)3.72888238
34dendritic spine morphogenesis (GO:0060997)3.70728872
35positive regulation of synapse maturation (GO:0090129)3.69602624
36dendrite morphogenesis (GO:0048813)3.69176589
37nonmotile primary cilium assembly (GO:0035058)3.69118502
38neuron-neuron synaptic transmission (GO:0007270)3.68252112
39auditory behavior (GO:0031223)3.65465054
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62203495
41neurotransmitter-gated ion channel clustering (GO:0072578)3.57277926
42gamma-aminobutyric acid transport (GO:0015812)3.55819651
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53819410
44axonal fasciculation (GO:0007413)3.51855899
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51453614
46neurotransmitter transport (GO:0006836)3.48048321
47positive regulation of membrane potential (GO:0045838)3.46685888
48activation of protein kinase A activity (GO:0034199)3.43629224
49organelle transport along microtubule (GO:0072384)3.35693973
50neuronal action potential propagation (GO:0019227)3.34619532
51establishment of mitochondrion localization (GO:0051654)3.33753354
52regulation of postsynaptic membrane potential (GO:0060078)3.33667804
53regulation of neurotransmitter secretion (GO:0046928)3.33250257
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.31495659
55mitochondrion transport along microtubule (GO:0047497)3.31495659
56synapse assembly (GO:0007416)3.29056872
57presynaptic membrane assembly (GO:0097105)3.28827554
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28702560
59adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.27653573
60regulation of vesicle fusion (GO:0031338)3.21297069
61synaptic vesicle endocytosis (GO:0048488)3.18806328
62dopamine receptor signaling pathway (GO:0007212)3.18650469
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.18386255
64regulation of neurotransmitter levels (GO:0001505)3.16943680
65innervation (GO:0060384)3.14956116
66regulation of synaptic plasticity (GO:0048167)3.14879962
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14622510
68retinal ganglion cell axon guidance (GO:0031290)3.12881578
69clathrin coat assembly (GO:0048268)3.12206438
70transmission of nerve impulse (GO:0019226)3.10889945
71long-term memory (GO:0007616)3.10492963
72presynaptic membrane organization (GO:0097090)3.10259600
73regulation of dendritic spine morphogenesis (GO:0061001)3.10100673
74vesicle transport along microtubule (GO:0047496)3.09318991
75axon extension (GO:0048675)3.08799159
76* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.08632703
77cellular potassium ion homeostasis (GO:0030007)3.07491881
78central nervous system projection neuron axonogenesis (GO:0021952)3.06173309
79long-term synaptic potentiation (GO:0060291)3.01680796
80positive regulation of neurotransmitter secretion (GO:0001956)3.01391144
81regulation of neurotransmitter transport (GO:0051588)3.00313548
82membrane depolarization during action potential (GO:0086010)2.99469560
83regulation of synaptic transmission, glutamatergic (GO:0051966)2.98544486
84membrane depolarization (GO:0051899)2.98269910
85positive regulation of neurotransmitter transport (GO:0051590)2.97929233
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96793163
87dendritic spine organization (GO:0097061)2.94929794
88learning (GO:0007612)2.94865074
89regulation of cAMP-dependent protein kinase activity (GO:2000479)2.93988517
90cerebellar granule cell differentiation (GO:0021707)2.93981686
91regulation of glutamate secretion (GO:0014048)2.93814753
92axon cargo transport (GO:0008088)2.91455330
93synapse organization (GO:0050808)2.91020078
94positive regulation of synapse assembly (GO:0051965)2.88190815
95central nervous system neuron axonogenesis (GO:0021955)2.87917631
96response to pheromone (GO:0019236)2.87885374
97mechanosensory behavior (GO:0007638)2.87668945
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87511502
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87244850
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.86131756
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85331311
102detection of calcium ion (GO:0005513)2.83747747
103synaptic transmission (GO:0007268)2.83685197
104positive regulation of dendritic spine development (GO:0060999)2.82141570
105behavioral response to ethanol (GO:0048149)2.81230825
106response to histamine (GO:0034776)2.80780601
107neuromuscular process controlling balance (GO:0050885)2.80546931
108establishment of synaptic vesicle localization (GO:0097480)2.80496960
109hippocampus development (GO:0021766)2.75236210
110regulation of synapse maturation (GO:0090128)2.72645119
111regulation of synapse assembly (GO:0051963)2.70577559
112response to auditory stimulus (GO:0010996)2.70322929
113neuronal ion channel clustering (GO:0045161)2.65320551
114forebrain neuron differentiation (GO:0021879)2.57308720
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56509640
116establishment of nucleus localization (GO:0040023)2.56042024
117* cell-cell adhesion (GO:0098609)2.49782956
118* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.49768968
119axonogenesis (GO:0007409)2.49579870
120spinal cord development (GO:0021510)2.48290487
121adult walking behavior (GO:0007628)2.48133596
122protein targeting to Golgi (GO:0000042)2.46539766
123cerebral cortex radially oriented cell migration (GO:0021799)2.45147971
124cerebellar Purkinje cell layer development (GO:0021680)2.42806633
125neuronal stem cell maintenance (GO:0097150)2.42778579
126dendrite development (GO:0016358)2.41870667
127inner ear receptor cell development (GO:0060119)2.41477077
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.39303211
129establishment of protein localization to Golgi (GO:0072600)2.37898437
130startle response (GO:0001964)2.36353223
131regulation of development, heterochronic (GO:0040034)2.36345989
132cranial nerve morphogenesis (GO:0021602)2.36312362
133regulation of synapse organization (GO:0050807)2.35943504
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.35543833
135axon extension involved in axon guidance (GO:0048846)2.35543833
136ephrin receptor signaling pathway (GO:0048013)2.35112981
137adult behavior (GO:0030534)2.34101794
138neuromuscular synaptic transmission (GO:0007274)2.33257397
139spinal cord motor neuron differentiation (GO:0021522)2.32590654
140behavioral defense response (GO:0002209)2.30573820
141behavioral fear response (GO:0001662)2.30573820
142ectodermal placode formation (GO:0060788)2.29081297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00296044
2GBX2_23144817_ChIP-Seq_PC3_Human4.03909907
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17975492
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03007453
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99322750
6REST_21632747_ChIP-Seq_MESCs_Mouse2.86553416
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62383825
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62180627
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60673931
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60673931
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.60462317
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58030860
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50736874
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49205517
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49181294
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45430268
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.31311193
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.25427901
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.23731081
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18706952
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16130594
22* EED_16625203_ChIP-ChIP_MESCs_Mouse2.15354208
23DROSHA_22980978_ChIP-Seq_HELA_Human2.12603475
24TAF15_26573619_Chip-Seq_HEK293_Human2.12145990
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.10515453
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06154062
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04993147
28AR_21572438_ChIP-Seq_LNCaP_Human2.04760084
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02109837
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94660909
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92752703
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.90226603
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80583607
34SMAD4_21799915_ChIP-Seq_A2780_Human1.73237125
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70143963
36ZNF274_21170338_ChIP-Seq_K562_Hela1.67762494
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64803686
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63584431
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60966208
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59924657
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58577549
42P300_19829295_ChIP-Seq_ESCs_Human1.56895825
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56647489
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54191754
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48170128
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.47250422
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46711563
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42959575
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.42252972
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39904564
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38627139
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36055117
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.35772394
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32832176
55AR_25329375_ChIP-Seq_VCAP_Human1.32105639
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29866545
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28833156
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28819091
59IGF1R_20145208_ChIP-Seq_DFB_Human1.24832568
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23710038
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23276977
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21593848
63STAT3_23295773_ChIP-Seq_U87_Human1.20940614
64RNF2_27304074_Chip-Seq_NSC_Mouse1.20323663
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.19427592
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16515234
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16380510
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15501917
69AR_19668381_ChIP-Seq_PC3_Human1.15395174
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13987837
71EWS_26573619_Chip-Seq_HEK293_Human1.13916272
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13723416
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.13447596
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12938320
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12398666
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.11913811
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11661687
78AHR_22903824_ChIP-Seq_MCF-7_Human1.11060215
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11050776
80FUS_26573619_Chip-Seq_HEK293_Human1.11038447
81SOX9_26525672_Chip-Seq_HEART_Mouse1.10462060
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09665707
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09615612
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.09413411
85TCF4_23295773_ChIP-Seq_U87_Human1.08487703
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.07631373
87CBP_20019798_ChIP-Seq_JUKART_Human1.07342009
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07342009
89JUN_21703547_ChIP-Seq_K562_Human1.05931331
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.05791981
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05671967
92VDR_22108803_ChIP-Seq_LS180_Human1.05053291
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04895082
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.04715611
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04311758
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03764780
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.03522809
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03512775
99RUNX2_22187159_ChIP-Seq_PCA_Human1.03464306
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03438702
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03432422
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03038839
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03014584
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02609770
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01836070
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.01761474
107SMAD3_21741376_ChIP-Seq_ESCs_Human1.01041724
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00277576
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99645146
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99645146
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99554463
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98320794
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97711623
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96899066
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95826902
116ER_23166858_ChIP-Seq_MCF-7_Human0.95521893
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.95430778
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94346424
119BCAT_22108803_ChIP-Seq_LS180_Human0.94178098
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93000383
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.91897747
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91874258
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88475733
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87681945
125TP53_18474530_ChIP-ChIP_U2OS_Human0.87669972
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87307297
127KDM2B_26808549_Chip-Seq_K562_Human0.85655945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87534852
2MP0004270_analgesia4.26424042
3MP0003880_abnormal_central_pattern4.21779456
4MP0003635_abnormal_synaptic_transmissio4.04871022
5MP0001968_abnormal_touch/_nociception3.59463116
6MP0002063_abnormal_learning/memory/cond3.30948072
7MP0009745_abnormal_behavioral_response3.22372026
8MP0002735_abnormal_chemical_nociception3.14242716
9MP0002734_abnormal_mechanical_nocicepti3.09993537
10MP0002064_seizures2.85667743
11MP0002736_abnormal_nociception_after2.85489925
12MP0002572_abnormal_emotion/affect_behav2.73847304
13MP0009046_muscle_twitch2.71854614
14MP0005423_abnormal_somatic_nervous2.69444498
15MP0002733_abnormal_thermal_nociception2.55796315
16MP0002272_abnormal_nervous_system2.44126453
17MP0006276_abnormal_autonomic_nervous2.37731624
18MP0000778_abnormal_nervous_system2.36274573
19MP0002822_catalepsy2.36199634
20MP0001440_abnormal_grooming_behavior2.29751819
21MP0004858_abnormal_nervous_system2.27516340
22MP0001970_abnormal_pain_threshold2.25553934
23MP0002184_abnormal_innervation2.24348257
24MP0003329_amyloid_beta_deposits2.20322667
25MP0001486_abnormal_startle_reflex2.19253403
26MP0001501_abnormal_sleep_pattern2.16312759
27MP0005248_abnormal_Harderian_gland2.11719639
28MP0002067_abnormal_sensory_capabilities2.01029350
29MP0004811_abnormal_neuron_physiology1.94521286
30MP0002653_abnormal_ependyma_morphology1.91078733
31MP0005386_behavior/neurological_phenoty1.88098738
32MP0004924_abnormal_behavior1.88098738
33MP0002557_abnormal_social/conspecific_i1.81794226
34MP0009780_abnormal_chondrocyte_physiolo1.81458479
35MP0001984_abnormal_olfaction1.79641870
36MP0000955_abnormal_spinal_cord1.70959606
37MP0002909_abnormal_adrenal_gland1.62128006
38MP0003119_abnormal_digestive_system1.53763327
39MP0002882_abnormal_neuron_morphology1.51739113
40MP0003890_abnormal_embryonic-extraembry1.51695701
41MP0008569_lethality_at_weaning1.51274543
42MP0004133_heterotaxia1.50883131
43MP0008995_early_reproductive_senescence1.50800655
44MP0002837_dystrophic_cardiac_calcinosis1.42110552
45MP0002066_abnormal_motor_capabilities/c1.41893747
46MP0003787_abnormal_imprinting1.41733337
47MP0003879_abnormal_hair_cell1.40925337
48MP0008877_abnormal_DNA_methylation1.39903217
49MP0001529_abnormal_vocalization1.36068927
50MP0001905_abnormal_dopamine_level1.34168744
51MP0003121_genomic_imprinting1.32422578
52MP0000566_synostosis1.24657442
53MP0002152_abnormal_brain_morphology1.19703338
54MP0003633_abnormal_nervous_system1.18424872
55MP0005645_abnormal_hypothalamus_physiol1.18264906
56MP0003567_abnormal_fetal_cardiomyocyte1.17036118
57MP0004885_abnormal_endolymph1.16458831
58MP0001346_abnormal_lacrimal_gland1.15143921
59MP0005499_abnormal_olfactory_system1.14972585
60MP0005394_taste/olfaction_phenotype1.14972585
61MP0000604_amyloidosis1.14367438
62MP0001188_hyperpigmentation1.13437561
63MP0000751_myopathy1.12139846
64MP0002233_abnormal_nose_morphology1.12048656
65MP0000647_abnormal_sebaceous_gland1.11611454
66MP0003283_abnormal_digestive_organ1.10626914
67MP0000049_abnormal_middle_ear1.10439693
68MP0002234_abnormal_pharynx_morphology1.09657390
69MP0003122_maternal_imprinting1.08393499
70MP0003631_nervous_system_phenotype1.07928311
71MP0003937_abnormal_limbs/digits/tail_de1.05662204
72MP0001502_abnormal_circadian_rhythm1.05029389
73MP0001293_anophthalmia1.03654253
74MP0000026_abnormal_inner_ear1.03575377
75MP0002254_reproductive_system_inflammat1.01007081
76MP0002697_abnormal_eye_size1.00777701
77MP0000537_abnormal_urethra_morphology1.00775377
78MP0005253_abnormal_eye_physiology1.00369036
79MP0001348_abnormal_lacrimal_gland1.00368885
80MP0010386_abnormal_urinary_bladder0.99017567
81MP0003755_abnormal_palate_morphology0.96292312
82MP0008872_abnormal_physiological_respon0.95632078
83MP0002069_abnormal_eating/drinking_beha0.95329534
84MP0002229_neurodegeneration0.93969599
85MP0000569_abnormal_digit_pigmentation0.92269717
86MP0005187_abnormal_penis_morphology0.90377531
87MP0004085_abnormal_heartbeat0.90126746
88MP0003634_abnormal_glial_cell0.90100550
89MP0004142_abnormal_muscle_tone0.90006944
90MP0002752_abnormal_somatic_nervous0.88847043
91MP0008789_abnormal_olfactory_epithelium0.87696216
92MP0002081_perinatal_lethality0.84702309
93MP0000427_abnormal_hair_cycle0.84285211
94MP0005646_abnormal_pituitary_gland0.84087701
95MP0004742_abnormal_vestibular_system0.83717823
96MP0003385_abnormal_body_wall0.82356864
97MP0003632_abnormal_nervous_system0.82019584
98MP0001485_abnormal_pinna_reflex0.81588305
99MP0005551_abnormal_eye_electrophysiolog0.79962312
100MP0002090_abnormal_vision0.79595786
101MP0006292_abnormal_olfactory_placode0.78887380
102MP0010030_abnormal_orbit_morphology0.78783166
103MP0000383_abnormal_hair_follicle0.77755963
104MP0000631_abnormal_neuroendocrine_gland0.77162350
105MP0008874_decreased_physiological_sensi0.76872845
106MP0000579_abnormal_nail_morphology0.76264866
107MP0000428_abnormal_craniofacial_morphol0.76188934
108MP0002116_abnormal_craniofacial_bone0.75902019
109MP0005391_vision/eye_phenotype0.75561823
110MP0003861_abnormal_nervous_system0.74062927
111MP0003011_delayed_dark_adaptation0.74003846
112MP0001286_abnormal_eye_development0.73707926
113MP0005535_abnormal_body_temperature0.73039966
114MP0001963_abnormal_hearing_physiology0.72851147
115MP0002751_abnormal_autonomic_nervous0.72298812
116MP0002638_abnormal_pupillary_reflex0.72070927
117MP0004484_altered_response_of0.71742664
118MP0002876_abnormal_thyroid_physiology0.70957219
119MP0004233_abnormal_muscle_weight0.69505216
120MP0000013_abnormal_adipose_tissue0.68806354
121MP0005623_abnormal_meninges_morphology0.67070133
122MP0004215_abnormal_myocardial_fiber0.66289748
123MP0001177_atelectasis0.65314449
124MP0001299_abnormal_eye_distance/0.64280725
125MP0009379_abnormal_foot_pigmentation0.61276633
126MP0001943_abnormal_respiration0.59007988
127MP0010234_abnormal_vibrissa_follicle0.56327096
128MP0001664_abnormal_digestion0.56236500
129MP0010770_preweaning_lethality0.54935356
130MP0002082_postnatal_lethality0.54935356
131MP0010769_abnormal_survival0.54112737
132MP0004145_abnormal_muscle_electrophysio0.54103894
133MP0003956_abnormal_body_size0.53105352
134MP0002102_abnormal_ear_morphology0.51142280
135MP0010768_mortality/aging0.50754404
136MP0003137_abnormal_impulse_conducting0.50680777
137MP0006072_abnormal_retinal_apoptosis0.50049589

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.97089102
2Focal motor seizures (HP:0011153)5.89773386
3Visual hallucinations (HP:0002367)5.23770889
4Focal seizures (HP:0007359)5.09546040
5Epileptic encephalopathy (HP:0200134)4.58151474
6Atonic seizures (HP:0010819)4.28243288
7Mutism (HP:0002300)4.07363147
8Absence seizures (HP:0002121)3.99873525
9Progressive cerebellar ataxia (HP:0002073)3.92135809
10Supranuclear gaze palsy (HP:0000605)3.87725703
11Limb dystonia (HP:0002451)3.64853748
12Febrile seizures (HP:0002373)3.60959093
13Termporal pattern (HP:0011008)3.59585540
14Insidious onset (HP:0003587)3.59585540
15Cerebral inclusion bodies (HP:0100314)3.57084472
16Dialeptic seizures (HP:0011146)3.49537575
17Generalized tonic-clonic seizures (HP:0002069)3.49123958
18Abnormality of the corticospinal tract (HP:0002492)3.48805224
19Papilledema (HP:0001085)3.31326253
20Amblyopia (HP:0000646)3.27058867
21Amyotrophic lateral sclerosis (HP:0007354)3.25657006
22Ankle clonus (HP:0011448)3.25280382
23Neurofibrillary tangles (HP:0002185)3.24362577
24Hyperventilation (HP:0002883)3.22915860
25Congenital primary aphakia (HP:0007707)3.20882244
26Action tremor (HP:0002345)3.20338697
27Drooling (HP:0002307)3.18944756
28Excessive salivation (HP:0003781)3.18944756
29Nephrogenic diabetes insipidus (HP:0009806)3.18900346
30Broad-based gait (HP:0002136)3.18824684
31Poor eye contact (HP:0000817)3.14674334
32Progressive inability to walk (HP:0002505)3.09647438
33Urinary bladder sphincter dysfunction (HP:0002839)3.07169505
34Polyphagia (HP:0002591)2.98227514
35Diplopia (HP:0000651)2.96710830
36Abnormality of binocular vision (HP:0011514)2.96710830
37Medial flaring of the eyebrow (HP:0010747)2.96434177
38Abnormal social behavior (HP:0012433)2.94458545
39Impaired social interactions (HP:0000735)2.94458545
40Pheochromocytoma (HP:0002666)2.92322133
41Truncal ataxia (HP:0002078)2.88489086
42Urinary urgency (HP:0000012)2.82776363
43Impaired vibration sensation in the lower limbs (HP:0002166)2.80897092
44Epileptiform EEG discharges (HP:0011182)2.77091773
45EEG with generalized epileptiform discharges (HP:0011198)2.73285089
46Depression (HP:0000716)2.69348830
47Abnormal eating behavior (HP:0100738)2.69152264
48Torticollis (HP:0000473)2.65855324
49Neuroendocrine neoplasm (HP:0100634)2.65267932
50Anxiety (HP:0000739)2.64664795
51Vaginal atresia (HP:0000148)2.63777019
52Spastic gait (HP:0002064)2.62676869
53Hypsarrhythmia (HP:0002521)2.62229097
54Poor coordination (HP:0002370)2.61943210
55Inappropriate behavior (HP:0000719)2.59334930
56Genital tract atresia (HP:0001827)2.58449661
57Hemiparesis (HP:0001269)2.54995768
58Akinesia (HP:0002304)2.54550111
59Cortical dysplasia (HP:0002539)2.54449196
60Apathy (HP:0000741)2.54186012
61Inability to walk (HP:0002540)2.53104864
62Hepatoblastoma (HP:0002884)2.51599586
63Nuclear cataract (HP:0100018)2.50931286
64Genetic anticipation (HP:0003743)2.46819171
65Focal dystonia (HP:0004373)2.44579290
66Agitation (HP:0000713)2.43782022
67Morphological abnormality of the pyramidal tract (HP:0002062)2.43037967
68Hypoplasia of the brainstem (HP:0002365)2.41288858
69Aplasia/Hypoplasia of the brainstem (HP:0007362)2.41288858
70Dysmetria (HP:0001310)2.36484474
71Intestinal atresia (HP:0011100)2.34866522
72Craniofacial dystonia (HP:0012179)2.34687381
73Lower limb muscle weakness (HP:0007340)2.34440610
74Gaze-evoked nystagmus (HP:0000640)2.34071201
75Abnormality of the lower motor neuron (HP:0002366)2.33446240
76Dysdiadochokinesis (HP:0002075)2.31124865
77Medulloblastoma (HP:0002885)2.30980035
78Nephronophthisis (HP:0000090)2.29177553
79Diminished motivation (HP:0000745)2.28991709
80Gait imbalance (HP:0002141)2.25763100
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.23704298
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23704298
83Oligodactyly (hands) (HP:0001180)2.22095866
84Fetal akinesia sequence (HP:0001989)2.20870149
85Stereotypic behavior (HP:0000733)2.20469664
86Bradykinesia (HP:0002067)2.20385691
87Double outlet right ventricle (HP:0001719)2.19593756
88Congenital malformation of the right heart (HP:0011723)2.19593756
89Septo-optic dysplasia (HP:0100842)2.19263532
90Delusions (HP:0000746)2.15811981
91Hyperthyroidism (HP:0000836)2.15663702
92Optic nerve hypoplasia (HP:0000609)2.12679320
93Abnormality of salivation (HP:0100755)2.11179962
94Scanning speech (HP:0002168)2.11077993
95Absent speech (HP:0001344)2.10991862
96Megalencephaly (HP:0001355)2.10888065
97Impaired smooth pursuit (HP:0007772)2.08887537
98Postural instability (HP:0002172)2.08643713
99Generalized myoclonic seizures (HP:0002123)2.07785953
100Impaired pain sensation (HP:0007328)2.04723096
101Abnormality of pain sensation (HP:0010832)2.04723096
102Failure to thrive in infancy (HP:0001531)2.02413650
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02161314
104Broad foot (HP:0001769)2.01982507
105Split foot (HP:0001839)2.01659706
106Lissencephaly (HP:0001339)2.00710271
107Hypoventilation (HP:0002791)1.99444066
108True hermaphroditism (HP:0010459)1.97445509
109Abnormality of the pubic bones (HP:0003172)1.97184020
110Lower limb amyotrophy (HP:0007210)1.96823110
111Thyroid-stimulating hormone excess (HP:0002925)1.96434492
112Postaxial hand polydactyly (HP:0001162)1.95222442
113Aqueductal stenosis (HP:0002410)1.94683068
114Exotropia (HP:0000577)1.91895575
115Oligodactyly (HP:0012165)1.91834737
116Neuronal loss in central nervous system (HP:0002529)1.91633729
117Chronic hepatic failure (HP:0100626)1.91410845
118Hypoplasia of the corpus callosum (HP:0002079)1.89794517
119Neoplasm of the peripheral nervous system (HP:0100007)1.89317110
120Rapidly progressive (HP:0003678)1.88635297
121Abnormality of the labia minora (HP:0012880)1.85564755
122Renal dysplasia (HP:0000110)1.85563171
123Protruding tongue (HP:0010808)1.85019508
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84651203
125Pachygyria (HP:0001302)1.84152266
126Specific learning disability (HP:0001328)1.83990385
127Psychosis (HP:0000709)1.82546524
128Sporadic (HP:0003745)1.81587262
129Blue irides (HP:0000635)1.80989510
130Pancreatic fibrosis (HP:0100732)1.80300248
131Abnormality of the renal medulla (HP:0100957)1.79759173
132Sleep apnea (HP:0010535)1.78971387
133Vitreoretinal degeneration (HP:0000655)1.77605401
134Aplasia/Hypoplasia of the lens (HP:0008063)1.74513257
135Micropenis (HP:0000054)1.74197186
136Decreased lacrimation (HP:0000633)1.74080306
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73379696
138Abnormality of the aortic arch (HP:0012303)1.73273892
139Decreased testicular size (HP:0008734)1.73238985
140Broad alveolar ridges (HP:0000187)1.70699734
141Papillary thyroid carcinoma (HP:0002895)1.70134156
142Occipital encephalocele (HP:0002085)1.69760571
143Labial hypoplasia (HP:0000066)1.68201081
144Abnormality of the ischium (HP:0003174)1.66992830
145Mixed hearing impairment (HP:0000410)1.64937797
146Spastic tetraplegia (HP:0002510)1.63817487
147Alacrima (HP:0000522)1.62251285
148Abnormality of midbrain morphology (HP:0002418)1.59054284
149Molar tooth sign on MRI (HP:0002419)1.59054284
150Spastic paraplegia (HP:0001258)1.58558066
151Intellectual disability, moderate (HP:0002342)1.57599591
152High anterior hairline (HP:0009890)1.57421615
153Paraplegia (HP:0010550)1.56970542
154Dental crowding (HP:0000678)1.56560983
155Unilateral renal agenesis (HP:0000122)1.56060828
156Postaxial foot polydactyly (HP:0001830)1.55926416
157Hypoplastic ischia (HP:0003175)1.54731794
158Neonatal respiratory distress (HP:0002643)1.54299344
159Chorioretinal coloboma (HP:0000567)1.53981103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.78700223
2MAP3K93.96040853
3NTRK33.58306674
4MAP3K123.11984000
5MAP3K43.07570499
6EPHA33.02687215
7MINK12.84130725
8MAP2K72.73445487
9NTRK22.41748053
10EPHA42.26490353
11CASK2.14938725
12DAPK22.13672742
13NTRK12.06839150
14MAP2K42.00868396
15MAPK132.00813815
16PHKG11.98789013
17PHKG21.98789013
18PNCK1.86804258
19PLK21.73229358
20KSR21.71002603
21PAK61.70058273
22DAPK11.69320398
23DYRK21.62691074
24GRK51.62062982
25KSR11.59915071
26LATS21.54213317
27STK38L1.53744884
28TRIM281.53695596
29DYRK31.51587247
30CDK51.42761726
31EPHB21.35781501
32MAP4K21.30047443
33ARAF1.29168551
34CAMKK11.28945129
35RIPK41.25436152
36TESK11.24739883
37NME11.23704125
38CSNK1G21.20312635
39UHMK11.16856438
40MKNK11.15883472
41PINK11.15686093
42ERBB31.13813592
43PRKCG1.12285924
44MAP3K21.12134805
45TNIK1.11460224
46MKNK21.07409439
47CAMKK21.06246644
48EPHB11.04955221
49SGK20.98875000
50CDK140.94210048
51RET0.92078994
52CAMK2A0.91663278
53SIK20.90391611
54CDK190.90390663
55DYRK1B0.88848635
56CDK180.88087769
57CDK150.85524539
58BRD40.82279681
59LIMK10.81004672
60CSNK1G30.79562002
61PAK30.78773090
62CDK11A0.75455410
63PDK40.75290792
64PDK30.75290792
65ERBB20.74741298
66GRK70.74610957
67TAOK10.72594894
68PRKCE0.72546515
69MARK20.71865287
70PRKD30.71529754
71PKN20.69950299
72DYRK1A0.69839814
73PRPF4B0.69133732
74STK110.68709069
75FES0.66792415
76MAP3K60.66599070
77SCYL20.66073614
78CAMK2B0.65803468
79INSRR0.63811659
80FGFR20.63620796
81SIK30.63341600
82PTK2B0.62573879
83SRPK10.62053439
84MAPK120.61821044
85CSNK1A1L0.61186544
86TYRO30.60979246
87TSSK60.60784615
88PKN10.59229331
89PASK0.59039491
90MET0.58282590
91RAF10.57956599
92CAMK1G0.57404971
93RPS6KA20.55851960
94FRK0.55566526
95ALK0.55308798
96PRKCZ0.55004150
97STK380.54593541
98PDGFRA0.54373030
99ADRBK10.54168732
100FGR0.54042924
101NEK10.53749169
102FER0.52110746
103NEK60.50470803
104SGK30.49720143
105WNK30.49350546
106SGK4940.48370237
107SGK2230.48370237
108CSNK1E0.48112348
109MAP2K60.48063092
110CSNK1D0.47775811
111SGK10.45948355
112CSNK1A10.45614983
113CAMK10.45465008
114BCR0.44517101
115MAP2K10.44316499
116PRKAA10.43535781
117RPS6KA40.42796966
118CAMK1D0.42664870
119FYN0.42564082
120AKT30.42181061
121MAPK90.40742885
122DAPK30.40435833
123DDR20.40243239
124CSNK1G10.39581543
125CAMK40.39408255
126PRKACB0.39391740
127RIPK10.39231946
128OXSR10.38746476
129BCKDK0.38161347
130PRKCH0.37356284
131CCNB10.37033065
132LMTK20.35066003
133BMPR1B0.34302279
134MAP3K130.33684391
135RPS6KA30.32333329
136CAMK2D0.30716772
137PRKCB0.29444841
138PDK10.28687998
139MAP3K10.27067769
140ROCK20.26210788

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.51579142
2Nicotine addiction_Homo sapiens_hsa050333.46713605
3Olfactory transduction_Homo sapiens_hsa047402.68202005
4Long-term potentiation_Homo sapiens_hsa047202.54643209
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53949177
6Circadian entrainment_Homo sapiens_hsa047132.53865959
7GABAergic synapse_Homo sapiens_hsa047272.49784347
8Dopaminergic synapse_Homo sapiens_hsa047282.26484051
9Glutamatergic synapse_Homo sapiens_hsa047242.26001835
10Morphine addiction_Homo sapiens_hsa050322.25345926
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19962255
12Amphetamine addiction_Homo sapiens_hsa050312.16259651
13Collecting duct acid secretion_Homo sapiens_hsa049662.07001800
14Cholinergic synapse_Homo sapiens_hsa047251.93999569
15Salivary secretion_Homo sapiens_hsa049701.93665491
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87947733
17Renin secretion_Homo sapiens_hsa049241.84968612
18Insulin secretion_Homo sapiens_hsa049111.76251186
19Taste transduction_Homo sapiens_hsa047421.72414224
20Steroid biosynthesis_Homo sapiens_hsa001001.71463916
21Serotonergic synapse_Homo sapiens_hsa047261.70377906
22Gastric acid secretion_Homo sapiens_hsa049711.68798882
23Long-term depression_Homo sapiens_hsa047301.68592335
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61252319
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56100939
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51802001
27Protein export_Homo sapiens_hsa030601.50903956
28Hippo signaling pathway_Homo sapiens_hsa043901.42545970
29Vibrio cholerae infection_Homo sapiens_hsa051101.41596613
30Gap junction_Homo sapiens_hsa045401.41198076
31GnRH signaling pathway_Homo sapiens_hsa049121.40629842
32Axon guidance_Homo sapiens_hsa043601.39980572
33Cocaine addiction_Homo sapiens_hsa050301.38143005
34Calcium signaling pathway_Homo sapiens_hsa040201.37113556
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33219709
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32938518
37Basal cell carcinoma_Homo sapiens_hsa052171.32616569
38Estrogen signaling pathway_Homo sapiens_hsa049151.30264418
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25916643
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20251716
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19893955
42Oxidative phosphorylation_Homo sapiens_hsa001901.17542149
43Glioma_Homo sapiens_hsa052141.16783698
44Cardiac muscle contraction_Homo sapiens_hsa042601.16103054
45Basal transcription factors_Homo sapiens_hsa030221.13237607
46Hedgehog signaling pathway_Homo sapiens_hsa043401.13043917
47Alzheimers disease_Homo sapiens_hsa050101.11616097
48Type II diabetes mellitus_Homo sapiens_hsa049301.11531796
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10563373
50Phototransduction_Homo sapiens_hsa047441.08878623
51cAMP signaling pathway_Homo sapiens_hsa040241.04482174
52Melanogenesis_Homo sapiens_hsa049161.03276158
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03070031
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.02948631
55ErbB signaling pathway_Homo sapiens_hsa040121.02038888
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00364633
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99130689
58Propanoate metabolism_Homo sapiens_hsa006400.96703553
59Oocyte meiosis_Homo sapiens_hsa041140.94129909
60Parkinsons disease_Homo sapiens_hsa050120.93916258
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93432492
62Circadian rhythm_Homo sapiens_hsa047100.92990097
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92903485
64Tight junction_Homo sapiens_hsa045300.90195147
65Dorso-ventral axis formation_Homo sapiens_hsa043200.90028425
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89271090
67mRNA surveillance pathway_Homo sapiens_hsa030150.88818186
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86753511
69beta-Alanine metabolism_Homo sapiens_hsa004100.86696011
70Notch signaling pathway_Homo sapiens_hsa043300.83498018
71Lysine degradation_Homo sapiens_hsa003100.82408327
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80845660
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.77961742
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70861092
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.70710569
76AMPK signaling pathway_Homo sapiens_hsa041520.69157377
77Butanoate metabolism_Homo sapiens_hsa006500.68859112
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68454732
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68391623
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67685316
81Regulation of autophagy_Homo sapiens_hsa041400.67663616
82Glucagon signaling pathway_Homo sapiens_hsa049220.67269906
83Endometrial cancer_Homo sapiens_hsa052130.66302368
84Alcoholism_Homo sapiens_hsa050340.65590105
85Huntingtons disease_Homo sapiens_hsa050160.64884485
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.64046231
87Thyroid hormone synthesis_Homo sapiens_hsa049180.62222728
88Choline metabolism in cancer_Homo sapiens_hsa052310.61713639
89Insulin signaling pathway_Homo sapiens_hsa049100.61113974
90MAPK signaling pathway_Homo sapiens_hsa040100.59972372
91VEGF signaling pathway_Homo sapiens_hsa043700.59578807
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59092491
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58815671
94Prion diseases_Homo sapiens_hsa050200.58315592
95Colorectal cancer_Homo sapiens_hsa052100.57263738
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57214862
97Fatty acid biosynthesis_Homo sapiens_hsa000610.56577023
98Ras signaling pathway_Homo sapiens_hsa040140.55107964
99Adherens junction_Homo sapiens_hsa045200.54839619
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54350246
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53265529
102Fatty acid metabolism_Homo sapiens_hsa012120.53200851
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52680113
104Renal cell carcinoma_Homo sapiens_hsa052110.52356530
105Pancreatic secretion_Homo sapiens_hsa049720.51437484
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.50647950
107Dilated cardiomyopathy_Homo sapiens_hsa054140.50362939
108TGF-beta signaling pathway_Homo sapiens_hsa043500.49759021
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48833304
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47605775
111mTOR signaling pathway_Homo sapiens_hsa041500.46355859
112Phagosome_Homo sapiens_hsa041450.45566614
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45494857
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45449838
115Selenocompound metabolism_Homo sapiens_hsa004500.44810106
116Inositol phosphate metabolism_Homo sapiens_hsa005620.43989587
117Rap1 signaling pathway_Homo sapiens_hsa040150.42805371
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42009683
119Type I diabetes mellitus_Homo sapiens_hsa049400.41557871
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38493044
121ABC transporters_Homo sapiens_hsa020100.37058112
122Arginine and proline metabolism_Homo sapiens_hsa003300.36421168
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36380394
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35901074
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35770229
126Wnt signaling pathway_Homo sapiens_hsa043100.35692791
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35405342
128Bile secretion_Homo sapiens_hsa049760.35037918
129Non-small cell lung cancer_Homo sapiens_hsa052230.34521500
130Rheumatoid arthritis_Homo sapiens_hsa053230.34496564
131Endocytosis_Homo sapiens_hsa041440.34259691
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32297243
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.30676021
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29076215

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