PCDHA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.84280889
2pyrimidine nucleobase catabolic process (GO:0006208)5.80529865
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80038420
4vocalization behavior (GO:0071625)5.78364035
5neuron cell-cell adhesion (GO:0007158)5.53316853
6protein localization to synapse (GO:0035418)5.36404440
7synaptic vesicle exocytosis (GO:0016079)5.34253424
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32495219
9synaptic vesicle maturation (GO:0016188)5.27948798
10regulation of glutamate receptor signaling pathway (GO:1900449)5.10957038
11auditory behavior (GO:0031223)4.93905649
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.93468866
13locomotory exploration behavior (GO:0035641)4.91746383
14neurotransmitter-gated ion channel clustering (GO:0072578)4.83804784
15nucleobase catabolic process (GO:0046113)4.82064311
16glutamate secretion (GO:0014047)4.75515780
17regulation of synaptic vesicle exocytosis (GO:2000300)4.75127699
18calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.66706954
19layer formation in cerebral cortex (GO:0021819)4.65997460
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.53186754
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48795064
22response to auditory stimulus (GO:0010996)4.37660783
23positive regulation of mitochondrial fission (GO:0090141)4.36634913
24postsynaptic membrane organization (GO:0001941)4.34662680
25exploration behavior (GO:0035640)4.31788448
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.29077422
27cell migration in hindbrain (GO:0021535)4.25870714
28regulation of synaptic vesicle transport (GO:1902803)4.22109345
29neurotransmitter secretion (GO:0007269)4.18703187
30positive regulation of synapse maturation (GO:0090129)4.14733017
31mechanosensory behavior (GO:0007638)4.02742736
32presynaptic membrane assembly (GO:0097105)4.02241335
33synaptic transmission, glutamatergic (GO:0035249)3.98327113
34regulation of synapse structural plasticity (GO:0051823)3.97632077
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92871897
36neuron recognition (GO:0008038)3.89489077
37dendritic spine morphogenesis (GO:0060997)3.89478107
38regulation of neuronal synaptic plasticity (GO:0048168)3.87720053
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86427335
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.78475739
41neuron-neuron synaptic transmission (GO:0007270)3.77179791
42glutamate receptor signaling pathway (GO:0007215)3.74453416
43proline transport (GO:0015824)3.74146687
44mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.72222472
45positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.72222472
46dendrite morphogenesis (GO:0048813)3.70382314
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68733747
48presynaptic membrane organization (GO:0097090)3.65601134
49retinal ganglion cell axon guidance (GO:0031290)3.63005278
50axonal fasciculation (GO:0007413)3.62814231
51righting reflex (GO:0060013)3.59643505
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59525674
53positive regulation of membrane potential (GO:0045838)3.58874106
54negative regulation of microtubule polymerization (GO:0031115)3.53727759
55gamma-aminobutyric acid transport (GO:0015812)3.52386400
56nonmotile primary cilium assembly (GO:0035058)3.51581100
57central nervous system projection neuron axonogenesis (GO:0021952)3.50707939
58neuronal action potential propagation (GO:0019227)3.49124389
59regulation of postsynaptic membrane potential (GO:0060078)3.46681279
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38841281
61neurotransmitter transport (GO:0006836)3.37762462
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36027348
63long-term memory (GO:0007616)3.34888197
64synapse assembly (GO:0007416)3.32161818
65C4-dicarboxylate transport (GO:0015740)3.30747344
66regulation of dendritic spine morphogenesis (GO:0061001)3.30201330
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.29317523
68activation of protein kinase A activity (GO:0034199)3.28116917
69* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.27734083
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.21347264
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20000285
72cerebellar Purkinje cell differentiation (GO:0021702)3.19686674
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.19588644
74behavioral response to nicotine (GO:0035095)3.19347036
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18682166
76sodium ion export (GO:0071436)3.18524037
77cellular potassium ion homeostasis (GO:0030007)3.18068837
78regulation of neurotransmitter secretion (GO:0046928)3.17314357
79regulation of synapse maturation (GO:0090128)3.16849914
80cell communication by electrical coupling (GO:0010644)3.16816730
81glycosphingolipid biosynthetic process (GO:0006688)3.15016307
82social behavior (GO:0035176)3.13633565
83intraspecies interaction between organisms (GO:0051703)3.13633565
84positive regulation of dendritic spine development (GO:0060999)3.13026378
85learning (GO:0007612)3.12780909
86membrane depolarization (GO:0051899)3.11458403
87cerebellar granule cell differentiation (GO:0021707)3.09092882
88establishment of mitochondrion localization (GO:0051654)3.08652472
89mitochondrion transport along microtubule (GO:0047497)3.07883170
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07883170
91regulation of synaptic plasticity (GO:0048167)3.07714570
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07583104
93clathrin coat assembly (GO:0048268)3.05385510
94pyrimidine dimer repair (GO:0006290)3.05247738
95membrane depolarization during action potential (GO:0086010)3.05019484
96response to pheromone (GO:0019236)3.04092568
97regulation of neurotransmitter levels (GO:0001505)3.03738178
98long-term synaptic potentiation (GO:0060291)3.03427810
99neuromuscular process controlling balance (GO:0050885)3.03046028
100regulation of vesicle fusion (GO:0031338)3.02903617
101regulation of synapse assembly (GO:0051963)3.01788016
102innervation (GO:0060384)3.00911723
103regulation of mitochondrial fission (GO:0090140)2.99352316
104negative regulation of oligodendrocyte differentiation (GO:0048715)2.98877850
105acidic amino acid transport (GO:0015800)2.98720694
106transmission of nerve impulse (GO:0019226)2.98543806
107synaptic vesicle endocytosis (GO:0048488)2.98247551
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98204793
109positive regulation of synapse assembly (GO:0051965)2.98193790
110hippocampus development (GO:0021766)2.97600340
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97529329
112regulation of dendritic spine development (GO:0060998)2.97130568
113short-term memory (GO:0007614)2.96631167
114cerebellum development (GO:0021549)2.96257321
115dendritic spine organization (GO:0097061)2.94479836
116regulation of development, heterochronic (GO:0040034)2.93844430
117synapse organization (GO:0050808)2.93446104
118neuromuscular synaptic transmission (GO:0007274)2.93445917
119regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.93283367
120membrane hyperpolarization (GO:0060081)2.92279260
121adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86768997
122neuronal ion channel clustering (GO:0045161)2.79621946
123response to dietary excess (GO:0002021)2.74968765
124behavioral response to cocaine (GO:0048148)2.66483492
125neuronal stem cell maintenance (GO:0097150)2.63038603
126behavioral response to ethanol (GO:0048149)2.62958337
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62620589
128* cell-cell adhesion (GO:0098609)2.61336288
129L-glutamate transport (GO:0015813)2.61111985
130* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.60157817
131cerebral cortex neuron differentiation (GO:0021895)2.58629214
132establishment of synaptic vesicle localization (GO:0097480)2.58530195
133synaptic vesicle transport (GO:0048489)2.58530195
134establishment of vesicle localization (GO:0051650)2.57399814
135positive regulation of action potential (GO:0045760)2.57228584
136central nervous system neuron axonogenesis (GO:0021955)2.56896333
137* nervous system development (GO:0007399)2.55366110
138protein localization to cilium (GO:0061512)2.54880054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88393316
2GBX2_23144817_ChIP-Seq_PC3_Human4.03211932
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13224077
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98522019
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94130604
6REST_21632747_ChIP-Seq_MESCs_Mouse2.84499780
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69564844
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.68669469
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61218169
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60687059
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60687059
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56182506
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50507390
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49869998
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48022586
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42168406
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40284968
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.35940470
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.35673706
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31873535
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.29614843
22DROSHA_22980978_ChIP-Seq_HELA_Human2.27781813
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25146249
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24155970
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.19837561
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18110383
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.14853261
28AR_21572438_ChIP-Seq_LNCaP_Human2.08081906
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02457395
30TAF15_26573619_Chip-Seq_HEK293_Human2.00123032
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97484808
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83724550
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74900030
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70617762
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62846633
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61436653
37SMAD4_21799915_ChIP-Seq_A2780_Human1.60811479
38ZNF274_21170338_ChIP-Seq_K562_Hela1.60709387
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54315621
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53984483
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51025290
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50359501
43P300_19829295_ChIP-Seq_ESCs_Human1.47602837
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43117575
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.42572676
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.42058733
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41592625
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41092635
49RNF2_27304074_Chip-Seq_NSC_Mouse1.40774880
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39145675
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.38042488
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.36714103
53IGF1R_20145208_ChIP-Seq_DFB_Human1.35098276
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34717000
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34147050
56AR_25329375_ChIP-Seq_VCAP_Human1.33132740
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.31445970
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30500300
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30415816
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29996340
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29126150
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27583687
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26509975
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26220872
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26083420
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.25559648
67AHR_22903824_ChIP-Seq_MCF-7_Human1.25177802
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24206935
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23639389
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22568327
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22123482
72CBP_20019798_ChIP-Seq_JUKART_Human1.20833968
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20833968
74AR_19668381_ChIP-Seq_PC3_Human1.20671866
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.20465874
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19083092
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.18485117
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18027458
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.17991854
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16164928
81EWS_26573619_Chip-Seq_HEK293_Human1.15978802
82STAT3_23295773_ChIP-Seq_U87_Human1.15655316
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15407714
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14863501
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14199437
86VDR_22108803_ChIP-Seq_LS180_Human1.13262549
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12721055
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12192663
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11894330
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08417412
91SOX9_26525672_Chip-Seq_HEART_Mouse1.06159185
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.06156344
93IRF1_19129219_ChIP-ChIP_H3396_Human1.05305834
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05145687
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04244636
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03642296
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03296134
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.02504924
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01559085
100TCF4_23295773_ChIP-Seq_U87_Human1.00820901
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00583262
102KDM2B_26808549_Chip-Seq_K562_Human1.00152109
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.00142691
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.98990476
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96509014
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96389778
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96070816
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96070816
109RUNX2_22187159_ChIP-Seq_PCA_Human0.95576461
110JUN_21703547_ChIP-Seq_K562_Human0.94542318
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94160707
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93986839
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93453320
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.93381843
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.93052259
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92684179
117KDM2B_26808549_Chip-Seq_REH_Human0.92004257
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91565020
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90909145
120TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90738939
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90471187
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90304053
123ER_23166858_ChIP-Seq_MCF-7_Human0.90154769
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89587189
125REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89116446
126FUS_26573619_Chip-Seq_HEK293_Human0.88813457
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87061015
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86638128
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.85825413
130POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85087043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.11123975
2MP0003880_abnormal_central_pattern4.48018119
3MP0003635_abnormal_synaptic_transmissio3.96253331
4MP0004270_analgesia3.77615109
5MP0002063_abnormal_learning/memory/cond3.31747894
6MP0009745_abnormal_behavioral_response3.07869510
7MP0001968_abnormal_touch/_nociception3.03406968
8MP0005423_abnormal_somatic_nervous2.98428713
9MP0002064_seizures2.82482234
10MP0002572_abnormal_emotion/affect_behav2.78768440
11MP0009046_muscle_twitch2.73659946
12MP0002734_abnormal_mechanical_nocicepti2.73184658
13MP0001529_abnormal_vocalization2.65877651
14MP0002735_abnormal_chemical_nociception2.54806994
15MP0001486_abnormal_startle_reflex2.47037628
16MP0002822_catalepsy2.44126805
17MP0002736_abnormal_nociception_after2.36756239
18MP0006276_abnormal_autonomic_nervous2.34581673
19MP0000778_abnormal_nervous_system2.29219198
20MP0002272_abnormal_nervous_system2.23604627
21MP0002733_abnormal_thermal_nociception2.19695467
22MP0002184_abnormal_innervation2.18756013
23MP0001440_abnormal_grooming_behavior2.16229883
24MP0009780_abnormal_chondrocyte_physiolo2.07800048
25MP0002067_abnormal_sensory_capabilities2.03594617
26MP0001970_abnormal_pain_threshold2.02285728
27MP0004811_abnormal_neuron_physiology1.96773659
28MP0010386_abnormal_urinary_bladder1.95402740
29MP0004924_abnormal_behavior1.88703590
30MP0005386_behavior/neurological_phenoty1.88703590
31MP0008569_lethality_at_weaning1.87572397
32MP0002557_abnormal_social/conspecific_i1.86679015
33MP0004858_abnormal_nervous_system1.84826539
34MP0001501_abnormal_sleep_pattern1.83755399
35MP0000569_abnormal_digit_pigmentation1.82446014
36MP0003329_amyloid_beta_deposits1.75831580
37MP0008789_abnormal_olfactory_epithelium1.59538458
38MP0002909_abnormal_adrenal_gland1.59054250
39MP0003879_abnormal_hair_cell1.58730310
40MP0001984_abnormal_olfaction1.58477890
41MP0001905_abnormal_dopamine_level1.58222461
42MP0000955_abnormal_spinal_cord1.58161665
43MP0002638_abnormal_pupillary_reflex1.57381860
44MP0002102_abnormal_ear_morphology1.55709108
45MP0002882_abnormal_neuron_morphology1.51736453
46MP0005367_renal/urinary_system_phenotyp1.49044349
47MP0000516_abnormal_urinary_system1.49044349
48MP0003890_abnormal_embryonic-extraembry1.42736484
49MP0002066_abnormal_motor_capabilities/c1.37178376
50MP0001502_abnormal_circadian_rhythm1.32268010
51MP0005646_abnormal_pituitary_gland1.31328569
52MP0005248_abnormal_Harderian_gland1.30752089
53MP0003121_genomic_imprinting1.30417440
54MP0001188_hyperpigmentation1.29834460
55MP0000049_abnormal_middle_ear1.28812922
56MP0002152_abnormal_brain_morphology1.23919832
57MP0002653_abnormal_ependyma_morphology1.21901823
58MP0008961_abnormal_basal_metabolism1.20648327
59MP0002837_dystrophic_cardiac_calcinosis1.18663154
60MP0003221_abnormal_cardiomyocyte_apopto1.17153846
61MP0000751_myopathy1.15995882
62MP0004885_abnormal_endolymph1.14929853
63MP0003787_abnormal_imprinting1.14076208
64MP0003122_maternal_imprinting1.12499539
65MP0003137_abnormal_impulse_conducting1.12370364
66MP0005253_abnormal_eye_physiology1.08115395
67MP0001986_abnormal_taste_sensitivity1.06955744
68MP0003633_abnormal_nervous_system1.05733893
69MP0003938_abnormal_ear_development1.05306055
70MP0003119_abnormal_digestive_system1.05028315
71MP0004142_abnormal_muscle_tone1.04470419
72MP0003011_delayed_dark_adaptation1.04395169
73MP0004742_abnormal_vestibular_system1.00221641
74MP0002234_abnormal_pharynx_morphology0.99068286
75MP0000534_abnormal_ureter_morphology0.96619973
76MP0005645_abnormal_hypothalamus_physiol0.96596939
77MP0002229_neurodegeneration0.96496153
78MP0004145_abnormal_muscle_electrophysio0.95656169
79MP0006292_abnormal_olfactory_placode0.94284322
80MP0005551_abnormal_eye_electrophysiolog0.94237422
81MP0003631_nervous_system_phenotype0.93478369
82MP0004085_abnormal_heartbeat0.91678300
83MP0004233_abnormal_muscle_weight0.91606523
84MP0000026_abnormal_inner_ear0.91426800
85MP0002069_abnormal_eating/drinking_beha0.91143190
86MP0004215_abnormal_myocardial_fiber0.90222713
87MP0000566_synostosis0.89810955
88MP0002233_abnormal_nose_morphology0.88342213
89MP0000631_abnormal_neuroendocrine_gland0.87976504
90MP0002752_abnormal_somatic_nervous0.86625749
91MP0001485_abnormal_pinna_reflex0.84181014
92MP0008872_abnormal_physiological_respon0.83739021
93MP0002751_abnormal_autonomic_nervous0.82765101
94MP0004130_abnormal_muscle_cell0.82415351
95MP0003861_abnormal_nervous_system0.82313177
96MP0003634_abnormal_glial_cell0.82109794
97MP0005187_abnormal_penis_morphology0.79232412
98MP0001293_anophthalmia0.77997690
99MP0001963_abnormal_hearing_physiology0.77062030
100MP0001348_abnormal_lacrimal_gland0.76243634
101MP0002938_white_spotting0.73459822
102MP0000604_amyloidosis0.72755160
103MP0002249_abnormal_larynx_morphology0.72555612
104MP0001299_abnormal_eye_distance/0.72232633
105MP0000013_abnormal_adipose_tissue0.71929768
106MP0002090_abnormal_vision0.71262350
107MP0005391_vision/eye_phenotype0.70179881
108MP0002081_perinatal_lethality0.69751542
109MP0008877_abnormal_DNA_methylation0.69536479
110MP0002876_abnormal_thyroid_physiology0.69146324
111MP0001664_abnormal_digestion0.68502002
112MP0003385_abnormal_body_wall0.67700528
113MP0003183_abnormal_peptide_metabolism0.66389450
114MP0003632_abnormal_nervous_system0.64473418
115MP0008874_decreased_physiological_sensi0.64371343
116MP0005394_taste/olfaction_phenotype0.62958080
117MP0005499_abnormal_olfactory_system0.62958080
118MP0010770_preweaning_lethality0.60307035
119MP0002082_postnatal_lethality0.60307035
120MP0001943_abnormal_respiration0.60023185
121MP0006072_abnormal_retinal_apoptosis0.59949826
122MP0005535_abnormal_body_temperature0.59828779
123MP0010769_abnormal_survival0.58501953
124MP0000538_abnormal_urinary_bladder0.57412865
125MP0004133_heterotaxia0.57193030
126MP0001177_atelectasis0.55014503
127MP0010768_mortality/aging0.54600196
128MP0003956_abnormal_body_size0.49978309
129MP0002089_abnormal_postnatal_growth/wei0.49958658

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.55518941
2Myokymia (HP:0002411)6.19196803
3Epileptic encephalopathy (HP:0200134)5.31264966
4Focal seizures (HP:0007359)5.06220801
5Visual hallucinations (HP:0002367)4.57131114
6Febrile seizures (HP:0002373)4.29085799
7Atonic seizures (HP:0010819)4.23182569
8Absence seizures (HP:0002121)3.91477235
9Progressive cerebellar ataxia (HP:0002073)3.74699966
10Action tremor (HP:0002345)3.69976179
11Mutism (HP:0002300)3.67870387
12Papilledema (HP:0001085)3.57664338
13Supranuclear gaze palsy (HP:0000605)3.57207901
14Dialeptic seizures (HP:0011146)3.57167603
15Generalized tonic-clonic seizures (HP:0002069)3.56065202
16Broad-based gait (HP:0002136)3.51042776
17Hyperventilation (HP:0002883)3.46885886
18Poor eye contact (HP:0000817)3.40555734
19Limb dystonia (HP:0002451)3.38629563
20Excessive salivation (HP:0003781)3.25415300
21Drooling (HP:0002307)3.25415300
22Amblyopia (HP:0000646)3.24775872
23Ankle clonus (HP:0011448)3.23388605
24Split foot (HP:0001839)3.20909680
25Nephrogenic diabetes insipidus (HP:0009806)3.20601113
26Congenital primary aphakia (HP:0007707)3.19541818
27Cortical dysplasia (HP:0002539)3.18063723
28Truncal ataxia (HP:0002078)3.17906008
29Abnormality of the corticospinal tract (HP:0002492)3.14634196
30Abnormality of the lower motor neuron (HP:0002366)3.11872815
31Urinary urgency (HP:0000012)3.07322321
32Impaired social interactions (HP:0000735)3.06265277
33Abnormal social behavior (HP:0012433)3.06265277
34Amyotrophic lateral sclerosis (HP:0007354)3.03093511
35Insidious onset (HP:0003587)3.00576927
36Termporal pattern (HP:0011008)3.00576927
37Medial flaring of the eyebrow (HP:0010747)2.95529251
38Abnormal eating behavior (HP:0100738)2.88147020
39Impaired vibration sensation in the lower limbs (HP:0002166)2.87705585
40Progressive inability to walk (HP:0002505)2.85731984
41Polyphagia (HP:0002591)2.85282339
42Urinary bladder sphincter dysfunction (HP:0002839)2.84655756
43Epileptiform EEG discharges (HP:0011182)2.78471774
44Depression (HP:0000716)2.75293413
45Spastic gait (HP:0002064)2.72563003
46Pheochromocytoma (HP:0002666)2.69810937
47Neonatal respiratory distress (HP:0002643)2.69449499
48EEG with generalized epileptiform discharges (HP:0011198)2.68526531
49Torticollis (HP:0000473)2.65262923
50Inability to walk (HP:0002540)2.64260452
51Vaginal atresia (HP:0000148)2.62962041
52Genital tract atresia (HP:0001827)2.55784080
53Cerebral inclusion bodies (HP:0100314)2.55672994
54Hypsarrhythmia (HP:0002521)2.55504915
55Gaze-evoked nystagmus (HP:0000640)2.55279263
56Retinal dysplasia (HP:0007973)2.49753024
57Anxiety (HP:0000739)2.49351496
58Hyperglycinemia (HP:0002154)2.48024382
59Hemiparesis (HP:0001269)2.46860683
60Dysdiadochokinesis (HP:0002075)2.46447551
61Abnormality of the musculature of the pelvis (HP:0001469)2.44585900
62Abnormality of the hip-girdle musculature (HP:0001445)2.44585900
63Neurofibrillary tangles (HP:0002185)2.43391189
64Gait imbalance (HP:0002141)2.42046489
65Akinesia (HP:0002304)2.38824379
66Neuroendocrine neoplasm (HP:0100634)2.38738629
67Pachygyria (HP:0001302)2.38405411
68Impaired smooth pursuit (HP:0007772)2.36704853
69Dysmetria (HP:0001310)2.36279380
70Focal dystonia (HP:0004373)2.31257742
71Postural instability (HP:0002172)2.28041996
72Poor coordination (HP:0002370)2.27734237
73Genetic anticipation (HP:0003743)2.27171852
74Lower limb muscle weakness (HP:0007340)2.25338566
75Agitation (HP:0000713)2.25238403
76Craniofacial dystonia (HP:0012179)2.24555258
77Diplopia (HP:0000651)2.22329247
78Abnormality of binocular vision (HP:0011514)2.22329247
79Morphological abnormality of the pyramidal tract (HP:0002062)2.21984649
80Hypoplastic pelvis (HP:0008839)2.21162697
81High anterior hairline (HP:0009890)2.20252907
82Bradykinesia (HP:0002067)2.18849549
83Hypoplasia of the corpus callosum (HP:0002079)2.17684796
84Scanning speech (HP:0002168)2.17299829
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16209787
86Hypoplasia of the brainstem (HP:0002365)2.16209787
87Megalencephaly (HP:0001355)2.15418317
88Stereotypic behavior (HP:0000733)2.13397507
89Specific learning disability (HP:0001328)2.13368796
90Protruding tongue (HP:0010808)2.11051094
91Hyperthyroidism (HP:0000836)2.10046588
92Abnormality of salivation (HP:0100755)2.09846092
93Thyroid-stimulating hormone excess (HP:0002925)2.09786412
94Inappropriate behavior (HP:0000719)2.09367863
95Absent speech (HP:0001344)2.07846175
96Renal hypoplasia (HP:0000089)2.05671429
97Abnormality of ocular smooth pursuit (HP:0000617)2.04276948
98Morphological abnormality of the middle ear (HP:0008609)2.04095401
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.03179861
100Exotropia (HP:0000577)2.02295558
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01832345
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.01832345
103Hypoventilation (HP:0002791)2.01306106
104Decreased testicular size (HP:0008734)2.00686423
105Colon cancer (HP:0003003)1.99955276
106Fetal akinesia sequence (HP:0001989)1.99830034
107Apathy (HP:0000741)1.99721057
108Obstructive sleep apnea (HP:0002870)1.99078743
109Tubulointerstitial nephritis (HP:0001970)1.98490829
110Insomnia (HP:0100785)1.97087499
111Lissencephaly (HP:0001339)1.96960805
112Failure to thrive in infancy (HP:0001531)1.95689831
113Abnormal hair whorl (HP:0010721)1.94673731
114Lower limb amyotrophy (HP:0007210)1.94194750
115Rib fusion (HP:0000902)1.93452418
116Abnormality of the astrocytes (HP:0100707)1.92898309
117Astrocytoma (HP:0009592)1.92898309
118Restlessness (HP:0000711)1.92460004
119Shoulder girdle muscle weakness (HP:0003547)1.92219824
120Narrow forehead (HP:0000341)1.91564965
121Esotropia (HP:0000565)1.89873523
122Poor suck (HP:0002033)1.87805801
123Intention tremor (HP:0002080)1.87648501
124Delusions (HP:0000746)1.87584853
125Ependymoma (HP:0002888)1.87234767
126Broad foot (HP:0001769)1.86540069
127Spastic tetraplegia (HP:0002510)1.86195400
128Polymicrogyria (HP:0002126)1.85874762
129Diminished motivation (HP:0000745)1.82629071
130Gastroesophageal reflux (HP:0002020)1.81544483
131Intestinal atresia (HP:0011100)1.81091850
132Pelvic girdle muscle weakness (HP:0003749)1.81025422
133Sleep apnea (HP:0010535)1.80372120
134Hepatoblastoma (HP:0002884)1.79356206
135Generalized myoclonic seizures (HP:0002123)1.78899747
136Heterochromia iridis (HP:0001100)1.78838165
137Methylmalonic acidemia (HP:0002912)1.78584890
138Papillary thyroid carcinoma (HP:0002895)1.78254446
139Muscular hypotonia of the trunk (HP:0008936)1.78072076
140Pointed chin (HP:0000307)1.74939072
141Pendular nystagmus (HP:0012043)1.74881943
142Medulloblastoma (HP:0002885)1.74389429
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73727940
144Neoplasm of the peripheral nervous system (HP:0100007)1.72748191
145True hermaphroditism (HP:0010459)1.71285647
146Optic nerve hypoplasia (HP:0000609)1.70998144
147Postaxial hand polydactyly (HP:0001162)1.69123622
148Postnatal microcephaly (HP:0005484)1.67000812
149Dyskinesia (HP:0100660)1.64213924
150Cerebral hypomyelination (HP:0006808)1.62370134
151Aplasia/Hypoplasia of the lens (HP:0008063)1.62273549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.52652481
2MAP3K94.14062873
3CASK3.52938647
4NTRK33.29998047
5MAP3K43.29943549
6MINK13.07849767
7MAP2K72.94675085
8NTRK22.75091012
9TRIM282.71134685
10EPHA42.30176897
11DAPK22.23591307
12DYRK22.21295955
13MAP2K41.95918730
14MAPK131.91633472
15KSR11.76093672
16SRPK11.73269285
17MAP3K121.73098520
18PHKG21.69572439
19PHKG11.69572439
20PAK61.68293890
21SIK31.63142985
22CDK51.54523725
23NTRK11.46113575
24ERBB31.44443152
25SIK21.39389458
26CAMKK11.39239073
27BCKDK1.33347079
28CSNK1G11.32064045
29LATS21.31759944
30CDK191.29780037
31PLK21.29741917
32KSR21.29611329
33RPS6KA41.29451863
34MAP4K21.28889521
35DAPK11.27872141
36STK38L1.27464735
37GRK51.20044410
38TNIK1.18657786
39CAMKK21.13886333
40CCNB11.13813395
41PRKCG1.11509795
42UHMK11.11303035
43TYRO31.10917612
44TAF11.09179806
45PKN21.05912008
46RET1.05123612
47CDK181.03805579
48BCR1.02745379
49MAP3K21.02212201
50EPHA31.00246012
51TESK10.98932453
52PRPF4B0.96892075
53CDK150.95287267
54EPHB20.94930917
55CDK140.94372692
56CSNK1G20.93126867
57PNCK0.90740498
58PRKD30.90572464
59FGFR20.86638639
60CAMK2A0.85772238
61MARK20.83909002
62CDK11A0.82986396
63EEF2K0.78525472
64SGK4940.78434255
65SGK2230.78434255
66STK380.74763306
67LIMK10.74163258
68DYRK1B0.73718736
69DYRK1A0.73564687
70PRKCZ0.72419802
71PINK10.69105604
72PAK30.69053637
73ARAF0.66736718
74TESK20.66613512
75FGFR30.66433374
76PRKCE0.63477666
77CAMK2B0.61714333
78RIPK40.61477236
79SCYL20.60320412
80LMTK20.57472666
81STK110.57412905
82MAP3K60.57381258
83MAPKAPK30.57175856
84RPS6KA20.55523674
85FYN0.55446278
86OXSR10.53835943
87CAMK2D0.52309781
88CAMK2G0.52033871
89CSNK1G30.51746140
90NEK10.51019618
91FGR0.51006141
92FES0.49534142
93EPHB10.49186301
94MAPK120.49161144
95FER0.47996954
96NME10.47205668
97PKN10.46624334
98PRKACB0.45529317
99PTK2B0.44383355
100CSNK1E0.44177263
101CAMK10.43786571
102SGK10.43669265
103CSNK1D0.43477057
104RPS6KB10.42334300
105PRKCH0.41502842
106ICK0.40626950
107INSRR0.40189470
108WNK30.39717923
109RPS6KA30.39060329
110RAF10.38801148
111MAP3K50.38130155
112MAPK90.36174224
113TSSK60.36127684
114CSNK1A1L0.35160003
115BMPR1B0.35153687
116ALK0.35026094
117MAPKAPK50.34440850
118CAMK1G0.33069153
119PDGFRA0.33007655
120MST1R0.32605838
121BRAF0.32414009
122AKT30.31494513
123PRKACA0.31481555
124ERBB20.31132384
125DYRK30.30949057
126CDK30.30923146
127MKNK20.30912442
128CSNK1A10.30513567
129MAPK100.30347818
130MAP2K10.30089246
131SGK20.29846473
132CDC42BPA0.29644980
133ADRBK10.29020946
134TNK20.27994403
135CAMK40.27983064
136PDK10.27458827
137PRKCB0.27397955
138MKNK10.27220113
139PRKAA10.26701657

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02260687
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48526163
3Olfactory transduction_Homo sapiens_hsa047402.67484987
4GABAergic synapse_Homo sapiens_hsa047272.63994231
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63399663
6Circadian entrainment_Homo sapiens_hsa047132.62148194
7Morphine addiction_Homo sapiens_hsa050322.41274930
8Glutamatergic synapse_Homo sapiens_hsa047242.37586869
9Long-term potentiation_Homo sapiens_hsa047202.34102446
10Amphetamine addiction_Homo sapiens_hsa050312.27261649
11Dopaminergic synapse_Homo sapiens_hsa047282.24400962
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23794001
13Cholinergic synapse_Homo sapiens_hsa047252.06217390
14Steroid biosynthesis_Homo sapiens_hsa001002.02899871
15Salivary secretion_Homo sapiens_hsa049701.91759129
16Insulin secretion_Homo sapiens_hsa049111.83308668
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82902584
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80564027
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71642833
20Cocaine addiction_Homo sapiens_hsa050301.68624858
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63786709
22Renin secretion_Homo sapiens_hsa049241.63234727
23Serotonergic synapse_Homo sapiens_hsa047261.62929090
24Propanoate metabolism_Homo sapiens_hsa006401.60956891
25Collecting duct acid secretion_Homo sapiens_hsa049661.57919305
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57904856
27Taste transduction_Homo sapiens_hsa047421.57263536
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56765442
29Gap junction_Homo sapiens_hsa045401.52842077
30Axon guidance_Homo sapiens_hsa043601.51688590
31Gastric acid secretion_Homo sapiens_hsa049711.50797921
32Long-term depression_Homo sapiens_hsa047301.49995477
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37185829
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32518495
35Calcium signaling pathway_Homo sapiens_hsa040201.32448164
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30317121
37GnRH signaling pathway_Homo sapiens_hsa049121.27107920
38Vibrio cholerae infection_Homo sapiens_hsa051101.23264784
39Protein export_Homo sapiens_hsa030601.16686398
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13277900
41Type II diabetes mellitus_Homo sapiens_hsa049301.12510756
42ErbB signaling pathway_Homo sapiens_hsa040121.12308150
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11929462
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11650988
45Cardiac muscle contraction_Homo sapiens_hsa042601.11584587
46Estrogen signaling pathway_Homo sapiens_hsa049151.11088364
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09777507
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07094099
49Glioma_Homo sapiens_hsa052141.06690106
50cAMP signaling pathway_Homo sapiens_hsa040241.06199556
51Phototransduction_Homo sapiens_hsa047441.05390596
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02103609
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97682426
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97449708
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94835824
56Caffeine metabolism_Homo sapiens_hsa002320.94123429
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93877849
58Melanogenesis_Homo sapiens_hsa049160.93304373
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92125474
60AMPK signaling pathway_Homo sapiens_hsa041520.89609330
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88411254
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87314096
63Hippo signaling pathway_Homo sapiens_hsa043900.85472779
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83221291
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82936149
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82652136
67Oocyte meiosis_Homo sapiens_hsa041140.80292754
68Biosynthesis of amino acids_Homo sapiens_hsa012300.80144046
69Dilated cardiomyopathy_Homo sapiens_hsa054140.76555591
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.75413407
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75389335
72Fatty acid metabolism_Homo sapiens_hsa012120.72606959
73Hedgehog signaling pathway_Homo sapiens_hsa043400.72445127
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.72285505
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.72199611
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.71479630
77Alcoholism_Homo sapiens_hsa050340.70652879
78Choline metabolism in cancer_Homo sapiens_hsa052310.70627489
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70453801
80Endometrial cancer_Homo sapiens_hsa052130.69465357
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69149023
82Ras signaling pathway_Homo sapiens_hsa040140.67093962
83MAPK signaling pathway_Homo sapiens_hsa040100.66581561
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66152135
85Glucagon signaling pathway_Homo sapiens_hsa049220.65274798
86Circadian rhythm_Homo sapiens_hsa047100.63853448
87Thyroid hormone synthesis_Homo sapiens_hsa049180.63609806
88Regulation of autophagy_Homo sapiens_hsa041400.63258656
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62468782
90Pyruvate metabolism_Homo sapiens_hsa006200.62034361
91Colorectal cancer_Homo sapiens_hsa052100.61918776
92VEGF signaling pathway_Homo sapiens_hsa043700.60617895
93Renal cell carcinoma_Homo sapiens_hsa052110.59103706
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58760006
95Arginine and proline metabolism_Homo sapiens_hsa003300.58667391
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57891145
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57614014
98mRNA surveillance pathway_Homo sapiens_hsa030150.57316431
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56933741
100Alzheimers disease_Homo sapiens_hsa050100.56500077
101Pancreatic secretion_Homo sapiens_hsa049720.56142038
102Basal cell carcinoma_Homo sapiens_hsa052170.55635593
103Insulin signaling pathway_Homo sapiens_hsa049100.55061099
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54511549
105Basal transcription factors_Homo sapiens_hsa030220.54057048
106mTOR signaling pathway_Homo sapiens_hsa041500.53174914
107Butanoate metabolism_Homo sapiens_hsa006500.52440412
108Rap1 signaling pathway_Homo sapiens_hsa040150.52421369
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.50700202
110Prion diseases_Homo sapiens_hsa050200.47156376
111Dorso-ventral axis formation_Homo sapiens_hsa043200.46734221
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46526621
113Tight junction_Homo sapiens_hsa045300.46221125
114Peroxisome_Homo sapiens_hsa041460.46022742
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45884383
116Huntingtons disease_Homo sapiens_hsa050160.45585079
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45291629
118Fatty acid elongation_Homo sapiens_hsa000620.44991578
119Wnt signaling pathway_Homo sapiens_hsa043100.44785357
120Endocytosis_Homo sapiens_hsa041440.44696554
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44509678
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44381029
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41620996
124Inositol phosphate metabolism_Homo sapiens_hsa005620.41454354
125Arginine biosynthesis_Homo sapiens_hsa002200.39804203
126Oxidative phosphorylation_Homo sapiens_hsa001900.39745423
127Bile secretion_Homo sapiens_hsa049760.39016568
128Non-small cell lung cancer_Homo sapiens_hsa052230.38783204
129Carbon metabolism_Homo sapiens_hsa012000.38445962
130Fructose and mannose metabolism_Homo sapiens_hsa000510.36602676
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36415576
132Phagosome_Homo sapiens_hsa041450.35198343
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34562498
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.34148086
135Parkinsons disease_Homo sapiens_hsa050120.33315460
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33181132
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32751069
138Fatty acid biosynthesis_Homo sapiens_hsa000610.29973806

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