PCDHA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.99918120
2vocalization behavior (GO:0071625)5.41416803
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35895898
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34216831
5fucose catabolic process (GO:0019317)5.25301631
6L-fucose metabolic process (GO:0042354)5.25301631
7L-fucose catabolic process (GO:0042355)5.25301631
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22746599
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20528834
10synaptic vesicle maturation (GO:0016188)5.13933317
11synaptic vesicle exocytosis (GO:0016079)5.09615599
12pyrimidine nucleobase catabolic process (GO:0006208)5.01130083
13regulation of synaptic vesicle exocytosis (GO:2000300)4.91301881
14regulation of glutamate receptor signaling pathway (GO:1900449)4.89454258
15glutamate secretion (GO:0014047)4.77663003
16protein localization to synapse (GO:0035418)4.77588262
17layer formation in cerebral cortex (GO:0021819)4.67838141
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.66887261
19locomotory exploration behavior (GO:0035641)4.63775973
20neuron recognition (GO:0008038)4.54974221
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.52596126
22cell migration in hindbrain (GO:0021535)4.39928620
23startle response (GO:0001964)4.39088548
24presynaptic membrane assembly (GO:0097105)4.37860143
25postsynaptic membrane organization (GO:0001941)4.35344508
26dendritic spine morphogenesis (GO:0060997)4.35215871
27nucleobase catabolic process (GO:0046113)4.31836449
28glutamate receptor signaling pathway (GO:0007215)4.28711879
29regulation of synaptic vesicle transport (GO:1902803)4.25141155
30exploration behavior (GO:0035640)4.19580929
31regulation of synapse structural plasticity (GO:0051823)4.17823726
32auditory behavior (GO:0031223)4.11468265
33neurotransmitter-gated ion channel clustering (GO:0072578)4.10772765
34axonal fasciculation (GO:0007413)4.09100924
35gamma-aminobutyric acid transport (GO:0015812)4.06306375
36proline transport (GO:0015824)4.01844310
37neurotransmitter secretion (GO:0007269)3.94522978
38presynaptic membrane organization (GO:0097090)3.90917243
39synaptic transmission, glutamatergic (GO:0035249)3.90132933
40dendrite morphogenesis (GO:0048813)3.89765406
41positive regulation of synapse maturation (GO:0090129)3.88129950
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79527927
43spinal cord development (GO:0021510)3.79292830
44neuron-neuron synaptic transmission (GO:0007270)3.75717617
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.74859528
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.73951056
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72333688
48regulation of neuronal synaptic plasticity (GO:0048168)3.69671172
49central nervous system projection neuron axonogenesis (GO:0021952)3.68266951
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.63463223
51establishment of mitochondrion localization (GO:0051654)3.60712828
52positive regulation of membrane potential (GO:0045838)3.58737887
53establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.57409777
54mitochondrion transport along microtubule (GO:0047497)3.57409777
55cerebellar granule cell differentiation (GO:0021707)3.57115587
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.56041016
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55570263
58negative regulation of microtubule polymerization (GO:0031115)3.54882261
59retinal ganglion cell axon guidance (GO:0031290)3.50022639
60regulation of dendritic spine morphogenesis (GO:0061001)3.48870195
61regulation of vesicle fusion (GO:0031338)3.48050545
62regulation of cAMP-dependent protein kinase activity (GO:2000479)3.43676528
63axon extension (GO:0048675)3.41978829
64synapse assembly (GO:0007416)3.41899386
65regulation of postsynaptic membrane potential (GO:0060078)3.41328363
66neuronal action potential propagation (GO:0019227)3.38319618
67positive regulation of synapse assembly (GO:0051965)3.35497677
68long-term memory (GO:0007616)3.33937212
69regulation of neurotransmitter secretion (GO:0046928)3.32162881
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31441048
71mechanosensory behavior (GO:0007638)3.31415855
72activation of protein kinase A activity (GO:0034199)3.30885469
73calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.30003424
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28462316
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26865013
76neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.25563077
77cerebellar Purkinje cell differentiation (GO:0021702)3.25301884
78neurofilament cytoskeleton organization (GO:0060052)3.24133993
79organelle transport along microtubule (GO:0072384)3.22677673
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22075852
81transmission of nerve impulse (GO:0019226)3.21828866
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.21026268
83nonmotile primary cilium assembly (GO:0035058)3.20323124
84neurotransmitter transport (GO:0006836)3.19493082
85negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18649639
86dopamine receptor signaling pathway (GO:0007212)3.17219584
87innervation (GO:0060384)3.17182268
88regulation of synapse maturation (GO:0090128)3.16123016
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15291135
90clathrin coat assembly (GO:0048268)3.09311012
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09178575
92regulation of dendritic spine development (GO:0060998)3.08042853
93regulation of synaptic plasticity (GO:0048167)3.03799157
94hindbrain development (GO:0030902)3.03296099
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.02906093
96response to histamine (GO:0034776)3.01160410
97somite development (GO:0061053)3.00736310
98neuron projection extension (GO:1990138)3.00639196
99behavioral response to nicotine (GO:0035095)2.98828676
100fucosylation (GO:0036065)2.98746359
101membrane depolarization (GO:0051899)2.97906025
102membrane hyperpolarization (GO:0060081)2.96618326
103positive regulation of dendritic spine development (GO:0060999)2.96299389
104long-term synaptic potentiation (GO:0060291)2.94958822
105synaptic vesicle endocytosis (GO:0048488)2.93800734
106regulation of synapse assembly (GO:0051963)2.93471492
107synapse organization (GO:0050808)2.93001752
108neuromuscular process controlling balance (GO:0050885)2.92739621
109regulation of synapse organization (GO:0050807)2.92471461
110regulation of neurotransmitter transport (GO:0051588)2.92006766
111ribonucleoprotein complex disassembly (GO:0032988)2.91729704
112mating behavior (GO:0007617)2.91696840
113membrane depolarization during action potential (GO:0086010)2.89763679
114dendrite development (GO:0016358)2.89552765
115negative regulation of dendrite development (GO:2000171)2.89079372
116spinal cord association neuron differentiation (GO:0021527)2.87452859
117social behavior (GO:0035176)2.87126408
118intraspecies interaction between organisms (GO:0051703)2.87126408
119central nervous system neuron axonogenesis (GO:0021955)2.87089463
120response to auditory stimulus (GO:0010996)2.81273420
121limb bud formation (GO:0060174)2.76970278
122serotonin metabolic process (GO:0042428)2.74358437
123response to pheromone (GO:0019236)2.73220928
124limb development (GO:0060173)2.71599485
125appendage development (GO:0048736)2.71599485
126protein localization to cilium (GO:0061512)2.71062586
127positive regulation of amino acid transport (GO:0051957)2.65135450
128forebrain neuron differentiation (GO:0021879)2.64987818
129glycosphingolipid biosynthetic process (GO:0006688)2.63747935
130intraciliary transport (GO:0042073)2.62750071
131epithelial cilium movement (GO:0003351)2.60985847
132axonemal dynein complex assembly (GO:0070286)2.60666752
133cilium or flagellum-dependent cell motility (GO:0001539)2.60203126
134primary amino compound metabolic process (GO:1901160)2.58026395
135neuronal stem cell maintenance (GO:0097150)2.57222459
136fucose metabolic process (GO:0006004)2.53793317
137neuronal ion channel clustering (GO:0045161)2.49540739
138* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.49058421
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.47283445
140axon extension involved in axon guidance (GO:0048846)2.47283445
141neuronal action potential (GO:0019228)2.45493029
142neurotransmitter catabolic process (GO:0042135)2.43914932
143otic vesicle formation (GO:0030916)2.42978328
144heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.40389169
145regulation of pigment cell differentiation (GO:0050932)2.38565360
146substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.38387449
147substrate-independent telencephalic tangential migration (GO:0021826)2.38387449
148ganglion development (GO:0061548)2.36493148
149adult walking behavior (GO:0007628)2.35764190
150chemosensory behavior (GO:0007635)2.35260356
151negative chemotaxis (GO:0050919)2.29507483
152positive regulation of gastrulation (GO:2000543)2.28967957
153positive regulation of developmental pigmentation (GO:0048087)2.27908647
154negative regulation of appetite (GO:0032099)2.27906071
155negative regulation of response to food (GO:0032096)2.27906071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.28164555
2GBX2_23144817_ChIP-Seq_PC3_Human3.84978299
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08846592
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05225041
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96816713
6REST_21632747_ChIP-Seq_MESCs_Mouse2.71291388
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59489158
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59489158
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.57583751
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56202823
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54906052
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53276472
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51928421
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41278845
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40829154
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36453114
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34765155
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34641666
19DROSHA_22980978_ChIP-Seq_HELA_Human2.31009466
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.25077732
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.22670200
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.20050907
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19921538
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18036374
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.15041825
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.13618571
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09598466
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04647632
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.04513913
30TAF15_26573619_Chip-Seq_HEK293_Human2.01434583
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00253291
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90445390
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81769564
34ZNF274_21170338_ChIP-Seq_K562_Hela1.79503778
35AR_21572438_ChIP-Seq_LNCaP_Human1.79458070
36IGF1R_20145208_ChIP-Seq_DFB_Human1.72944978
37SMAD4_21799915_ChIP-Seq_A2780_Human1.72383938
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65769116
39EWS_26573619_Chip-Seq_HEK293_Human1.64577590
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63792827
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61671217
42P300_19829295_ChIP-Seq_ESCs_Human1.56150700
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54968646
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.53878365
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51099396
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.47735626
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45840340
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44964199
49VDR_22108803_ChIP-Seq_LS180_Human1.44816434
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.44795138
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44684295
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43506040
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42937284
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42747545
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40706372
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.39899732
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36376803
58FUS_26573619_Chip-Seq_HEK293_Human1.35870554
59AR_25329375_ChIP-Seq_VCAP_Human1.34837262
60RNF2_27304074_Chip-Seq_NSC_Mouse1.34218563
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33646951
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30574812
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29210168
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28659574
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28210600
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.27523138
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.27283799
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.25748018
69IRF1_19129219_ChIP-ChIP_H3396_Human1.25045176
70STAT3_23295773_ChIP-Seq_U87_Human1.23901114
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23004371
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21094626
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.19503781
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19272863
75TCF4_23295773_ChIP-Seq_U87_Human1.16925231
76AR_19668381_ChIP-Seq_PC3_Human1.16750536
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16199909
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16199909
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15884131
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15135027
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14310577
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14243340
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13989834
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13971507
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13798008
86SOX9_26525672_Chip-Seq_HEART_Mouse1.09172213
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07775743
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.07374547
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06570389
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06516416
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.06267385
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05861752
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.05574817
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05300368
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04994875
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04512530
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03990123
98RUNX2_22187159_ChIP-Seq_PCA_Human1.03532469
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.03092817
100ER_23166858_ChIP-Seq_MCF-7_Human1.02458256
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02343009
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00415203
103CBP_20019798_ChIP-Seq_JUKART_Human0.99584847
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99584847
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99115745
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.98995053
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98550049
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98430022
109AHR_22903824_ChIP-Seq_MCF-7_Human0.97492103
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.97309478
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95566178
112JUN_21703547_ChIP-Seq_K562_Human0.94953580
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94823423
114TP53_16413492_ChIP-PET_HCT116_Human0.94777069
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93066848
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92637694
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.90571354
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90543280
119TP53_18474530_ChIP-ChIP_U2OS_Human0.90403698
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90032737
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89265440
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87054787
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86865751
124BCAT_22108803_ChIP-Seq_LS180_Human0.86682243
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86351093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46012440
2MP0003136_yellow_coat_color4.88567628
3MP0003880_abnormal_central_pattern4.55358791
4MP0004270_analgesia4.02526428
5MP0003635_abnormal_synaptic_transmissio4.00061493
6MP0002063_abnormal_learning/memory/cond3.26999275
7MP0005423_abnormal_somatic_nervous3.22331735
8MP0001968_abnormal_touch/_nociception3.19122838
9MP0009745_abnormal_behavioral_response3.08871706
10MP0002734_abnormal_mechanical_nocicepti2.90969622
11MP0002064_seizures2.89106491
12MP0009046_muscle_twitch2.88769397
13MP0002735_abnormal_chemical_nociception2.79457692
14MP0002572_abnormal_emotion/affect_behav2.69190875
15MP0003283_abnormal_digestive_organ2.68019521
16MP0000778_abnormal_nervous_system2.61272424
17MP0002733_abnormal_thermal_nociception2.57277167
18MP0002736_abnormal_nociception_after2.52104582
19MP0001486_abnormal_startle_reflex2.39885103
20MP0001440_abnormal_grooming_behavior2.34083999
21MP0006276_abnormal_autonomic_nervous2.33990653
22MP0002272_abnormal_nervous_system2.27357334
23MP0002184_abnormal_innervation2.22672903
24MP0001970_abnormal_pain_threshold2.17709818
25MP0000569_abnormal_digit_pigmentation2.16599656
26MP0003329_amyloid_beta_deposits2.07399465
27MP0002938_white_spotting2.05252256
28MP0002067_abnormal_sensory_capabilities2.05142391
29MP0005386_behavior/neurological_phenoty2.04750050
30MP0004924_abnormal_behavior2.04750050
31MP0003890_abnormal_embryonic-extraembry1.98626550
32MP0004133_heterotaxia1.97096996
33MP0002557_abnormal_social/conspecific_i1.96579788
34MP0004858_abnormal_nervous_system1.94872845
35MP0000566_synostosis1.94743332
36MP0001986_abnormal_taste_sensitivity1.86853112
37MP0001984_abnormal_olfaction1.82613590
38MP0004811_abnormal_neuron_physiology1.80616987
39MP0008995_early_reproductive_senescence1.80229590
40MP0001501_abnormal_sleep_pattern1.77334046
41MP0003119_abnormal_digestive_system1.74644035
42MP0000955_abnormal_spinal_cord1.69507810
43MP0002102_abnormal_ear_morphology1.68314687
44MP0001529_abnormal_vocalization1.68037209
45MP0003787_abnormal_imprinting1.68001712
46MP0002822_catalepsy1.58480499
47MP0002638_abnormal_pupillary_reflex1.56717509
48MP0002882_abnormal_neuron_morphology1.54236364
49MP0008569_lethality_at_weaning1.52426100
50MP0009780_abnormal_chondrocyte_physiolo1.49106796
51MP0001293_anophthalmia1.46229570
52MP0002066_abnormal_motor_capabilities/c1.45145201
53MP0000537_abnormal_urethra_morphology1.43191938
54MP0003315_abnormal_perineum_morphology1.42414055
55MP0010030_abnormal_orbit_morphology1.42114785
56MP0002909_abnormal_adrenal_gland1.41495294
57MP0003879_abnormal_hair_cell1.36380579
58MP0005645_abnormal_hypothalamus_physiol1.31862022
59MP0002152_abnormal_brain_morphology1.27620695
60MP0005171_absent_coat_pigmentation1.22792184
61MP0000534_abnormal_ureter_morphology1.22668158
62MP0009379_abnormal_foot_pigmentation1.20321234
63MP0004885_abnormal_endolymph1.20019371
64MP0004142_abnormal_muscle_tone1.19559752
65MP0005551_abnormal_eye_electrophysiolog1.18673035
66MP0001502_abnormal_circadian_rhythm1.17334807
67MP0003123_paternal_imprinting1.12837702
68MP0000049_abnormal_middle_ear1.12169303
69MP0003633_abnormal_nervous_system1.11995246
70MP0000427_abnormal_hair_cycle1.10225140
71MP0003122_maternal_imprinting1.07997951
72MP0001905_abnormal_dopamine_level1.07972770
73MP0005394_taste/olfaction_phenotype1.06191083
74MP0005499_abnormal_olfactory_system1.06191083
75MP0004742_abnormal_vestibular_system1.05377782
76MP0000751_myopathy1.05231077
77MP0001188_hyperpigmentation1.04297875
78MP0003631_nervous_system_phenotype1.00776204
79MP0002069_abnormal_eating/drinking_beha0.99657901
80MP0002229_neurodegeneration0.99008079
81MP0003937_abnormal_limbs/digits/tail_de0.97819133
82MP0002752_abnormal_somatic_nervous0.96614136
83MP0005253_abnormal_eye_physiology0.94516640
84MP0002233_abnormal_nose_morphology0.94363524
85MP0002653_abnormal_ependyma_morphology0.93307029
86MP0002697_abnormal_eye_size0.92399534
87MP0000631_abnormal_neuroendocrine_gland0.92248927
88MP0005646_abnormal_pituitary_gland0.90540396
89MP0003634_abnormal_glial_cell0.90518606
90MP0003861_abnormal_nervous_system0.90114907
91MP0000604_amyloidosis0.89915138
92MP0001324_abnormal_eye_pigmentation0.88843572
93MP0003878_abnormal_ear_physiology0.88461142
94MP0005377_hearing/vestibular/ear_phenot0.88461142
95MP0003942_abnormal_urinary_system0.88200383
96MP0000462_abnormal_digestive_system0.87608564
97MP0010386_abnormal_urinary_bladder0.86120785
98MP0005195_abnormal_posterior_eye0.85763056
99MP0006072_abnormal_retinal_apoptosis0.84951689
100MP0005367_renal/urinary_system_phenotyp0.84758171
101MP0000516_abnormal_urinary_system0.84758171
102MP0000026_abnormal_inner_ear0.84658382
103MP0001348_abnormal_lacrimal_gland0.84549007
104MP0004085_abnormal_heartbeat0.82840579
105MP0002751_abnormal_autonomic_nervous0.81587003
106MP0004215_abnormal_myocardial_fiber0.79189231
107MP0006292_abnormal_olfactory_placode0.78722722
108MP0008874_decreased_physiological_sensi0.78593583
109MP0001286_abnormal_eye_development0.77415130
110MP0001963_abnormal_hearing_physiology0.77411613
111MP0003632_abnormal_nervous_system0.76650008
112MP0005248_abnormal_Harderian_gland0.75872819
113MP0005391_vision/eye_phenotype0.75448381
114MP0008961_abnormal_basal_metabolism0.75297878
115MP0003941_abnormal_skin_development0.73829925
116MP0008872_abnormal_physiological_respon0.71530317
117MP0002090_abnormal_vision0.70623036
118MP0001177_atelectasis0.67763531
119MP0002876_abnormal_thyroid_physiology0.67074046
120MP0008789_abnormal_olfactory_epithelium0.66798349
121MP0003137_abnormal_impulse_conducting0.66716687
122MP0002234_abnormal_pharynx_morphology0.63457263
123MP0002837_dystrophic_cardiac_calcinosis0.63346837
124MP0010770_preweaning_lethality0.63141331
125MP0002082_postnatal_lethality0.63141331
126MP0004145_abnormal_muscle_electrophysio0.61884131
127MP0000920_abnormal_myelination0.61600493
128MP0001299_abnormal_eye_distance/0.61582026
129MP0010769_abnormal_survival0.61050599
130MP0004233_abnormal_muscle_weight0.59741329
131MP0004484_altered_response_of0.59391190
132MP0010768_mortality/aging0.56820171
133MP0003121_genomic_imprinting0.55939688
134MP0005187_abnormal_penis_morphology0.55755850
135MP0001943_abnormal_respiration0.55749588
136MP0003938_abnormal_ear_development0.54866218
137MP0003956_abnormal_body_size0.54580771
138MP0005623_abnormal_meninges_morphology0.54450765
139MP0005448_abnormal_energy_balance0.54347684

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.96667391
2Epileptic encephalopathy (HP:0200134)5.67013800
3Myokymia (HP:0002411)5.60344655
4Focal seizures (HP:0007359)5.22325242
5Visual hallucinations (HP:0002367)4.68039901
6Febrile seizures (HP:0002373)3.87802283
7Atonic seizures (HP:0010819)3.86802671
8Mutism (HP:0002300)3.74659708
9Progressive cerebellar ataxia (HP:0002073)3.72741113
10Excessive salivation (HP:0003781)3.64274302
11Drooling (HP:0002307)3.64274302
12Abnormality of the corticospinal tract (HP:0002492)3.62119994
13Amyotrophic lateral sclerosis (HP:0007354)3.58178536
14Supranuclear gaze palsy (HP:0000605)3.52797171
15Poor eye contact (HP:0000817)3.49085077
16Broad-based gait (HP:0002136)3.47569458
17Generalized tonic-clonic seizures (HP:0002069)3.47141145
18Hyperventilation (HP:0002883)3.34399592
19Absence seizures (HP:0002121)3.33044670
20Amblyopia (HP:0000646)3.25061901
21Epileptiform EEG discharges (HP:0011182)3.15052133
22Neurofibrillary tangles (HP:0002185)3.11562761
23EEG with generalized epileptiform discharges (HP:0011198)3.11559087
24Polyphagia (HP:0002591)3.11223851
25Cerebral inclusion bodies (HP:0100314)3.09936832
26Dialeptic seizures (HP:0011146)3.07514109
27Ankle clonus (HP:0011448)3.07371077
28Impaired social interactions (HP:0000735)3.06304470
29Abnormal social behavior (HP:0012433)3.06304470
30Hypsarrhythmia (HP:0002521)2.99304101
31Limb dystonia (HP:0002451)2.95104220
32Abnormal eating behavior (HP:0100738)2.92086844
33Insidious onset (HP:0003587)2.91793877
34Termporal pattern (HP:0011008)2.91793877
35Impaired vibration sensation in the lower limbs (HP:0002166)2.90883203
36Truncal ataxia (HP:0002078)2.90684241
37Action tremor (HP:0002345)2.89863900
38Septo-optic dysplasia (HP:0100842)2.87190442
39Akinesia (HP:0002304)2.84892532
40Abnormal respiratory motile cilium morphology (HP:0005938)2.84699572
41Abnormal respiratory epithelium morphology (HP:0012253)2.84699572
42Myelomeningocele (HP:0002475)2.79971807
43Abnormality of the lower motor neuron (HP:0002366)2.64435630
44Progressive inability to walk (HP:0002505)2.63358856
45Hyperinsulinemic hypoglycemia (HP:0000825)2.60604978
46Urinary bladder sphincter dysfunction (HP:0002839)2.59932353
47Cutaneous finger syndactyly (HP:0010554)2.58772559
48Depression (HP:0000716)2.56981045
49Ulnar claw (HP:0001178)2.56818511
50Pheochromocytoma (HP:0002666)2.56725206
51Fetal akinesia sequence (HP:0001989)2.56608052
52Spastic gait (HP:0002064)2.56399191
53Agitation (HP:0000713)2.52340966
54Inappropriate behavior (HP:0000719)2.52208153
55Urinary urgency (HP:0000012)2.50403779
56Vaginal atresia (HP:0000148)2.48856761
57Gaze-evoked nystagmus (HP:0000640)2.48576040
58Shawl scrotum (HP:0000049)2.47961326
59Hypoplastic pelvis (HP:0008839)2.46074422
60Absent speech (HP:0001344)2.45950260
61Protruding tongue (HP:0010808)2.43081652
62Genital tract atresia (HP:0001827)2.42991760
63Abnormality of salivation (HP:0100755)2.40265759
64Anxiety (HP:0000739)2.39571881
65Molar tooth sign on MRI (HP:0002419)2.36545065
66Abnormality of midbrain morphology (HP:0002418)2.36545065
67Dysdiadochokinesis (HP:0002075)2.36114351
68Abnormality of the labia minora (HP:0012880)2.34721833
69Bilateral microphthalmos (HP:0007633)2.34108598
70Hemiparesis (HP:0001269)2.33334957
71Abnormality of binocular vision (HP:0011514)2.31505891
72Diplopia (HP:0000651)2.31505891
73Absent septum pellucidum (HP:0001331)2.30944220
74Papilledema (HP:0001085)2.29702129
75Dysmetria (HP:0001310)2.29254448
76Shoulder girdle muscle weakness (HP:0003547)2.27477260
77Hypoplasia of the brainstem (HP:0002365)2.26710896
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.26710896
79Pendular nystagmus (HP:0012043)2.26469698
80Inability to walk (HP:0002540)2.26358556
81Scanning speech (HP:0002168)2.25895331
82Stenosis of the external auditory canal (HP:0000402)2.25508736
83Genetic anticipation (HP:0003743)2.22870511
84Anophthalmia (HP:0000528)2.21651820
85Stereotypic behavior (HP:0000733)2.21409219
86Lissencephaly (HP:0001339)2.20876985
87Nephronophthisis (HP:0000090)2.18905958
88Lower limb muscle weakness (HP:0007340)2.18740943
89Hepatoblastoma (HP:0002884)2.15579541
90Esotropia (HP:0000565)2.15005769
91Keratoconus (HP:0000563)2.14918773
92Increased corneal curvature (HP:0100692)2.14918773
93Morphological abnormality of the pyramidal tract (HP:0002062)2.14869993
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13094041
95Degeneration of the lateral corticospinal tracts (HP:0002314)2.13094041
96Status epilepticus (HP:0002133)2.12236505
97Neuroendocrine neoplasm (HP:0100634)2.11560038
98Cutaneous syndactyly (HP:0012725)2.11308904
99Impaired smooth pursuit (HP:0007772)2.10914568
100Apathy (HP:0000741)2.10897662
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10043751
102Torticollis (HP:0000473)2.08978839
103Gait imbalance (HP:0002141)2.08907082
104Maternal diabetes (HP:0009800)2.08793103
105Pachygyria (HP:0001302)2.08398809
106Exotropia (HP:0000577)2.06696255
107Open mouth (HP:0000194)2.03624249
108Congenital primary aphakia (HP:0007707)2.03124783
109Gonadotropin excess (HP:0000837)2.02742160
110Chronic otitis media (HP:0000389)2.01811125
111Abnormality of macular pigmentation (HP:0008002)2.01643840
112Hyperthyroidism (HP:0000836)2.00386856
113Hyperglycinuria (HP:0003108)1.96605915
114Autism (HP:0000717)1.96465334
115Specific learning disability (HP:0001328)1.95808703
116Postural instability (HP:0002172)1.95121615
117Abnormality of ocular smooth pursuit (HP:0000617)1.94379957
118Focal dystonia (HP:0004373)1.92588528
119Medial flaring of the eyebrow (HP:0010747)1.92280648
120Bifid tongue (HP:0010297)1.91815782
121Sporadic (HP:0003745)1.91764437
122Blue irides (HP:0000635)1.91487082
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.91240141
124Athetosis (HP:0002305)1.91226932
125Bradykinesia (HP:0002067)1.90790139
126Obstructive sleep apnea (HP:0002870)1.90738644
127Renal hypoplasia (HP:0000089)1.87724475
128Aqueductal stenosis (HP:0002410)1.87433710
129Sleep apnea (HP:0010535)1.87271933
130Hypoventilation (HP:0002791)1.86188218
131Nephrogenic diabetes insipidus (HP:0009806)1.85758640
132Generalized myoclonic seizures (HP:0002123)1.85592594
133Decreased central vision (HP:0007663)1.84640045
134Diminished motivation (HP:0000745)1.84638140
135Intestinal atresia (HP:0011100)1.84627087
136Generalized hypotonia (HP:0001290)1.84518691
137Hypothermia (HP:0002045)1.84022344
138Volvulus (HP:0002580)1.83790659
139Abnormal hair whorl (HP:0010721)1.83089624
140Abnormality of the septum pellucidum (HP:0007375)1.81507839
141Narrow forehead (HP:0000341)1.79950803
142Megalencephaly (HP:0001355)1.79371604
143Abnormality of the aortic arch (HP:0012303)1.78475825
144Vitreoretinal degeneration (HP:0000655)1.78376181
145Pancreatic fibrosis (HP:0100732)1.77823781
146Sclerocornea (HP:0000647)1.76695712
147Meningocele (HP:0002435)1.75339618
148Decreased testicular size (HP:0008734)1.72905593
149True hermaphroditism (HP:0010459)1.72309995
150Bicornuate uterus (HP:0000813)1.70566129
151Muscular hypotonia of the trunk (HP:0008936)1.69774572
152Failure to thrive in infancy (HP:0001531)1.69019287
153Pancreatic cysts (HP:0001737)1.68214302
154Scrotal hypoplasia (HP:0000046)1.67320292
155Optic nerve hypoplasia (HP:0000609)1.66740297
156Aplasia involving bones of the upper limbs (HP:0009823)1.65738652
157Aplasia of the phalanges of the hand (HP:0009802)1.65738652
158Aplasia involving bones of the extremities (HP:0009825)1.65738652
159Thyroid-stimulating hormone excess (HP:0002925)1.64927246
160Hyperglycinemia (HP:0002154)1.63357126
161Anencephaly (HP:0002323)1.63139546
162Abnormality of the renal medulla (HP:0100957)1.62756584
163Rib fusion (HP:0000902)1.59014527
164Esophageal atresia (HP:0002032)1.57530144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.47804787
2NTRK33.58826190
3MAP3K92.98296330
4MAP3K42.89044376
5CASK2.85509385
6NTRK22.76478533
7MINK12.68537672
8MAP2K72.58894195
9INSRR2.52084113
10EPHA42.49201733
11MAPK132.20334253
12SIK22.08707517
13DAPK22.08269082
14MAP2K41.95311151
15MAP3K121.90598267
16PAK61.90113911
17RIPK41.85818920
18TNIK1.82582821
19PNCK1.78693813
20NTRK11.65923559
21LATS21.65616350
22PHKG11.64838018
23PHKG21.64838018
24KSR11.63422694
25PRPF4B1.58971184
26DYRK21.54889458
27DYRK31.44469379
28KSR21.44335689
29CDK51.43566377
30EPHB21.42659714
31CAMKK11.35623941
32TRIM281.34207335
33UHMK11.29949210
34PLK21.28110893
35FRK1.25495712
36DAPK11.20069789
37PINK11.17796848
38PRKCG1.12190503
39AKT31.11457754
40ERBB31.09917170
41MAP3K61.08929900
42CAMKK21.05882155
43DYRK1A1.04128672
44PLK41.03186644
45GRK51.03057329
46FES0.97957993
47NME10.94883836
48CSNK1G20.93441293
49MAP3K20.92627308
50PKN10.92575639
51GRK10.92321893
52CDK190.91819732
53CAMK2A0.91027849
54PAK30.90028928
55CDK140.87708275
56RPS6KA20.86601633
57ERBB40.86161747
58ACVR1B0.85686004
59CDK180.84288072
60CDK150.81888511
61ICK0.81815207
62PIK3CA0.79495720
63EIF2AK10.78767666
64CAMK2B0.78297626
65MARK20.77269705
66PIM20.76621439
67DYRK1B0.75865362
68EPHA30.75424768
69RET0.74413030
70SGK4940.73586429
71SGK2230.73586429
72CDK11A0.71469565
73CAMK1G0.68513096
74MAP4K20.68472015
75BMPR20.64599644
76PRKCZ0.63902094
77STK380.63325584
78BCR0.61610093
79TYRO30.60638566
80CCNB10.60157077
81CAMK2G0.59567755
82CSNK1G10.59529322
83LIMK10.59269655
84STK110.58217740
85CAMK10.57434436
86MAP3K50.56608040
87SGK20.56375157
88ALK0.55296100
89MUSK0.55167535
90ZAK0.55127880
91MAPK120.55085377
92BMPR1B0.53881443
93OXSR10.52894562
94PRKCE0.51700777
95SGK10.51685676
96CSNK1E0.50337651
97PTK60.49799361
98PRKACA0.48348322
99BCKDK0.47450704
100RAF10.46407514
101CSNK1G30.45466972
102RPS6KB10.44186841
103MAP2K10.44185886
104ERBB20.43073685
105PRKACB0.42080149
106CAMK40.40326506
107SIK30.40154209
108SCYL20.40073345
109ADRBK10.39182947
110FYN0.39026075
111CAMK2D0.39009931
112RPS6KA30.38766002
113MAPK90.38384980
114PASK0.37840986
115CSNK1D0.37781978
116WNK30.36689530
117FER0.36243913
118DAPK30.35868470
119PRKG10.35437896
120CSNK1A1L0.35052685
121PTK2B0.35044044
122DMPK0.34653825
123MAPK40.34197635
124PRKCB0.33983212
125FGFR20.33955942
126PRKDC0.33925910
127LMTK20.32894517
128MAPK100.31711226
129ARAF0.31539286
130ROCK20.31467073
131PRKCH0.30623980
132FGR0.30113811
133SGK30.30048053

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.75012202
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15367014
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86861154
4Circadian entrainment_Homo sapiens_hsa047132.82190686
5GABAergic synapse_Homo sapiens_hsa047272.80714030
6Morphine addiction_Homo sapiens_hsa050322.55856859
7Glutamatergic synapse_Homo sapiens_hsa047242.53352199
8Long-term potentiation_Homo sapiens_hsa047202.49062253
9Olfactory transduction_Homo sapiens_hsa047402.47967316
10Protein export_Homo sapiens_hsa030602.41549554
11Amphetamine addiction_Homo sapiens_hsa050312.25539632
12Dopaminergic synapse_Homo sapiens_hsa047282.22842293
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18579888
14Steroid biosynthesis_Homo sapiens_hsa001002.09694812
15Cholinergic synapse_Homo sapiens_hsa047252.06069386
16Long-term depression_Homo sapiens_hsa047302.05078370
17Salivary secretion_Homo sapiens_hsa049701.92651789
18Serotonergic synapse_Homo sapiens_hsa047261.90086702
19Taste transduction_Homo sapiens_hsa047421.89629958
20Insulin secretion_Homo sapiens_hsa049111.84303094
21Renin secretion_Homo sapiens_hsa049241.70339831
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.70038685
23Oxytocin signaling pathway_Homo sapiens_hsa049211.66784794
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64192355
25Basal cell carcinoma_Homo sapiens_hsa052171.58208509
26Axon guidance_Homo sapiens_hsa043601.57990893
27Gastric acid secretion_Homo sapiens_hsa049711.57014829
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53810974
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51524142
30Cocaine addiction_Homo sapiens_hsa050301.51106342
31Collecting duct acid secretion_Homo sapiens_hsa049661.50540730
32GnRH signaling pathway_Homo sapiens_hsa049121.46390222
33Gap junction_Homo sapiens_hsa045401.46165847
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42959103
35Propanoate metabolism_Homo sapiens_hsa006401.41011820
36Estrogen signaling pathway_Homo sapiens_hsa049151.37534191
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36784826
38Calcium signaling pathway_Homo sapiens_hsa040201.32670117
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27418362
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24150467
41ErbB signaling pathway_Homo sapiens_hsa040121.21610731
42Hippo signaling pathway_Homo sapiens_hsa043901.21215536
43Type II diabetes mellitus_Homo sapiens_hsa049301.17240212
44Huntingtons disease_Homo sapiens_hsa050161.15570957
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14321157
46Glioma_Homo sapiens_hsa052141.13375761
47Melanogenesis_Homo sapiens_hsa049161.12070114
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10110842
49RNA polymerase_Homo sapiens_hsa030201.08895395
50Phototransduction_Homo sapiens_hsa047441.08213876
51cAMP signaling pathway_Homo sapiens_hsa040241.07832078
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03201302
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01109454
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00101338
55beta-Alanine metabolism_Homo sapiens_hsa004100.99566315
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99532801
57Hedgehog signaling pathway_Homo sapiens_hsa043400.98883564
58Vibrio cholerae infection_Homo sapiens_hsa051100.98487005
59Cardiac muscle contraction_Homo sapiens_hsa042600.98479270
60Basal transcription factors_Homo sapiens_hsa030220.98202955
61Linoleic acid metabolism_Homo sapiens_hsa005910.92922426
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90902797
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87282979
64Ether lipid metabolism_Homo sapiens_hsa005650.85538667
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83918491
66Dorso-ventral axis formation_Homo sapiens_hsa043200.83848770
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.78610414
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78152203
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76871419
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.75198602
71Oocyte meiosis_Homo sapiens_hsa041140.74393950
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73959896
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72058352
74Choline metabolism in cancer_Homo sapiens_hsa052310.70324920
75Endometrial cancer_Homo sapiens_hsa052130.69597799
76Alzheimers disease_Homo sapiens_hsa050100.69115844
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.69021032
78MAPK signaling pathway_Homo sapiens_hsa040100.67875852
79TGF-beta signaling pathway_Homo sapiens_hsa043500.64724749
80Ras signaling pathway_Homo sapiens_hsa040140.64343006
81Alcoholism_Homo sapiens_hsa050340.63122666
82Dilated cardiomyopathy_Homo sapiens_hsa054140.62225572
83Prion diseases_Homo sapiens_hsa050200.61834282
84Renal cell carcinoma_Homo sapiens_hsa052110.61606993
85Thyroid hormone synthesis_Homo sapiens_hsa049180.61572016
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60804439
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60706382
88Fatty acid metabolism_Homo sapiens_hsa012120.59645849
89Fatty acid elongation_Homo sapiens_hsa000620.59601089
90VEGF signaling pathway_Homo sapiens_hsa043700.59076097
91Pancreatic secretion_Homo sapiens_hsa049720.57605913
92Glucagon signaling pathway_Homo sapiens_hsa049220.56274007
93Circadian rhythm_Homo sapiens_hsa047100.56164445
94Sulfur metabolism_Homo sapiens_hsa009200.55900625
95Colorectal cancer_Homo sapiens_hsa052100.55640292
96Wnt signaling pathway_Homo sapiens_hsa043100.55193759
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53864472
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.53412991
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53377343
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53022520
101mTOR signaling pathway_Homo sapiens_hsa041500.52477846
102Rap1 signaling pathway_Homo sapiens_hsa040150.52476924
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50254493
104Fanconi anemia pathway_Homo sapiens_hsa034600.49791931
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.49604455
106Insulin signaling pathway_Homo sapiens_hsa049100.48686405
107Butanoate metabolism_Homo sapiens_hsa006500.48316814
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47643715
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47482041
110Ribosome_Homo sapiens_hsa030100.47345988
111mRNA surveillance pathway_Homo sapiens_hsa030150.45810133
112Tight junction_Homo sapiens_hsa045300.45648344
113Oxidative phosphorylation_Homo sapiens_hsa001900.44965272
114Peroxisome_Homo sapiens_hsa041460.44566213
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43511070
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43332329
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42231338
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42077630
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.40566105
120Non-small cell lung cancer_Homo sapiens_hsa052230.39989589
121Metabolic pathways_Homo sapiens_hsa011000.38900648
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38799466
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38220985
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38173984
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38053478
126Endocytosis_Homo sapiens_hsa041440.37506453
127AMPK signaling pathway_Homo sapiens_hsa041520.37431323
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37024750
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36862026
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36110165
131African trypanosomiasis_Homo sapiens_hsa051430.35860627
132Inositol phosphate metabolism_Homo sapiens_hsa005620.33850798
133Ovarian steroidogenesis_Homo sapiens_hsa049130.32281188
134Parkinsons disease_Homo sapiens_hsa050120.32097761
135Bile secretion_Homo sapiens_hsa049760.28899117
136Phagosome_Homo sapiens_hsa041450.28698266
137Prolactin signaling pathway_Homo sapiens_hsa049170.26836086

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