PCDHA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.16139620
2neuron cell-cell adhesion (GO:0007158)6.14873037
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46437976
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01504251
5neuron recognition (GO:0008038)4.92949148
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80650071
7protein localization to synapse (GO:0035418)4.74669763
8synaptic vesicle exocytosis (GO:0016079)4.72209013
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62912667
10innervation (GO:0060384)4.60569215
11regulation of glutamate receptor signaling pathway (GO:1900449)4.56837428
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.52213718
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.49554547
14axonal fasciculation (GO:0007413)4.44364486
15neuronal action potential propagation (GO:0019227)4.37474244
16dendritic spine morphogenesis (GO:0060997)4.20231453
17synaptic transmission, glutamatergic (GO:0035249)4.14440620
18pyrimidine nucleobase catabolic process (GO:0006208)4.14428112
19presynaptic membrane assembly (GO:0097105)4.11573083
20glutamate receptor signaling pathway (GO:0007215)4.08733079
21gamma-aminobutyric acid signaling pathway (GO:0007214)4.08493901
22startle response (GO:0001964)4.03658275
23regulation of synaptic vesicle exocytosis (GO:2000300)4.00578557
24neuron-neuron synaptic transmission (GO:0007270)3.99558735
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93963139
26substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.87655628
27substrate-independent telencephalic tangential migration (GO:0021826)3.87655628
28postsynaptic membrane organization (GO:0001941)3.84311926
29glutamate secretion (GO:0014047)3.83443479
30cell wall macromolecule catabolic process (GO:0016998)3.82486258
31locomotory exploration behavior (GO:0035641)3.73220579
32inner ear receptor cell development (GO:0060119)3.68367951
33neurotransmitter secretion (GO:0007269)3.67983770
34cell migration in hindbrain (GO:0021535)3.66773182
35negative regulation of multicellular organism growth (GO:0040015)3.65779466
36transmission of nerve impulse (GO:0019226)3.65303669
37cerebellar Purkinje cell differentiation (GO:0021702)3.64595376
38ganglion development (GO:0061548)3.62800293
39behavioral response to nicotine (GO:0035095)3.62792474
40presynaptic membrane organization (GO:0097090)3.61020904
41positive regulation of synapse assembly (GO:0051965)3.59856806
42detection of calcium ion (GO:0005513)3.58318992
43cytoplasmic mRNA processing body assembly (GO:0033962)3.57239178
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.57017438
45negative regulation of microtubule polymerization (GO:0031115)3.55646275
46layer formation in cerebral cortex (GO:0021819)3.54743725
47neurotransmitter-gated ion channel clustering (GO:0072578)3.53222609
48regulation of postsynaptic membrane potential (GO:0060078)3.51595350
49gamma-aminobutyric acid transport (GO:0015812)3.50213783
50behavioral response to ethanol (GO:0048149)3.47961417
51regulation of synaptic vesicle transport (GO:1902803)3.47440632
52hippocampus development (GO:0021766)3.46261504
53striatum development (GO:0021756)3.46064052
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45199007
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44374972
56sex differentiation (GO:0007548)3.43511741
57nucleobase catabolic process (GO:0046113)3.40200425
58positive regulation of membrane potential (GO:0045838)3.40160430
59synaptic vesicle maturation (GO:0016188)3.39177865
60sympathetic nervous system development (GO:0048485)3.38705262
61exploration behavior (GO:0035640)3.36855302
62synapse assembly (GO:0007416)3.36422115
63positive regulation of synapse maturation (GO:0090129)3.34672105
64membrane hyperpolarization (GO:0060081)3.32920158
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32478302
66regulation of neuronal synaptic plasticity (GO:0048168)3.31561727
67regulation of action potential (GO:0098900)3.31397685
68dendrite morphogenesis (GO:0048813)3.29924513
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28833025
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.27648198
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27344177
72cochlea development (GO:0090102)3.27314478
73central nervous system projection neuron axonogenesis (GO:0021952)3.26797765
74retinal ganglion cell axon guidance (GO:0031290)3.26112656
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.23990373
76regulation of vesicle fusion (GO:0031338)3.23722673
77* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.23385360
78regulation of synapse structural plasticity (GO:0051823)3.21597445
79cerebellar granule cell differentiation (GO:0021707)3.21592762
80regulation of synapse assembly (GO:0051963)3.21203760
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20469142
82neuromuscular process controlling posture (GO:0050884)3.19383104
83membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.18659025
84protein localization to cilium (GO:0061512)3.18571743
85positive regulation of potassium ion transmembrane transport (GO:1901381)3.18084262
86cell wall macromolecule metabolic process (GO:0044036)3.16794312
87negative regulation of dendrite development (GO:2000171)3.16613733
88proline transport (GO:0015824)3.15742192
89righting reflex (GO:0060013)3.14238339
90negative regulation of dendrite morphogenesis (GO:0050774)3.12302482
91behavioral response to cocaine (GO:0048148)3.08336713
92axon extension (GO:0048675)3.08007413
93neurotransmitter transport (GO:0006836)3.07960330
94cAMP-mediated signaling (GO:0019933)3.05851314
95response to histamine (GO:0034776)3.05400719
96cell differentiation in hindbrain (GO:0021533)3.02908626
97auditory behavior (GO:0031223)3.02126058
98central nervous system neuron axonogenesis (GO:0021955)3.01207753
99adult walking behavior (GO:0007628)3.00849010
100cerebral cortex cell migration (GO:0021795)3.00494196
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99887133
102membrane depolarization (GO:0051899)2.98850381
103long-term synaptic potentiation (GO:0060291)2.98280758
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98043202
105establishment of mitochondrion localization (GO:0051654)2.97589950
106short-term memory (GO:0007614)2.97154472
107regulation of feeding behavior (GO:0060259)2.93498118
108mechanosensory behavior (GO:0007638)2.93154785
109regulation of dendritic spine morphogenesis (GO:0061001)2.92631700
110membrane repolarization during action potential (GO:0086011)2.92367313
111chemosensory behavior (GO:0007635)2.91821760
112regulation of synaptic transmission, GABAergic (GO:0032228)2.88004053
113negative regulation of oligodendrocyte differentiation (GO:0048715)2.87764268
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86773670
115regulation of synaptic plasticity (GO:0048167)2.85760434
116dendrite development (GO:0016358)2.85702343
117membrane depolarization during action potential (GO:0086010)2.85486308
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85484739
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.84425327
120synapse organization (GO:0050808)2.83784389
121neuromuscular synaptic transmission (GO:0007274)2.81590851
122regulation of synapse organization (GO:0050807)2.81467743
123long-term memory (GO:0007616)2.80878022
124regulation of respiratory system process (GO:0044065)2.80166823
125response to auditory stimulus (GO:0010996)2.78852275
126regulation of synapse maturation (GO:0090128)2.78581076
127intraspecies interaction between organisms (GO:0051703)2.76458163
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.73703900
129C4-dicarboxylate transport (GO:0015740)2.71522915
130positive regulation of dendritic spine development (GO:0060999)2.70932354
131cerebral cortex radially oriented cell migration (GO:0021799)2.67227915
132somite rostral/caudal axis specification (GO:0032525)2.66325811
133spinal cord development (GO:0021510)2.65549252
134ADP metabolic process (GO:0046031)2.62332134
135regulation of sarcomere organization (GO:0060297)2.56434435
136olfactory bulb development (GO:0021772)2.55656638
137stress granule assembly (GO:0034063)2.54099446
138neural tube formation (GO:0001841)2.53504852
139* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.49966537
140* cell-cell adhesion (GO:0098609)2.49945851
141axonogenesis (GO:0007409)2.49359308
142positive regulation of heat generation (GO:0031652)2.49336431
143positive regulation of dendrite morphogenesis (GO:0050775)2.49249072
144behavioral fear response (GO:0001662)2.47666693
145behavioral defense response (GO:0002209)2.47666693
146cerebral cortex neuron differentiation (GO:0021895)2.47451385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22682037
2GBX2_23144817_ChIP-Seq_PC3_Human4.18570972
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11434721
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07081634
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04490540
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94251488
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84812319
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.64302299
9TAF15_26573619_Chip-Seq_HEK293_Human2.62033018
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50527786
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49585355
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48128937
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48128937
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47886661
15REST_21632747_ChIP-Seq_MESCs_Mouse2.43984979
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38669490
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34549968
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29323580
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.28793696
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26191072
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.24935474
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21100056
23AR_21572438_ChIP-Seq_LNCaP_Human2.18861304
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16136568
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.11943986
26DROSHA_22980978_ChIP-Seq_HELA_Human2.11549709
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11519646
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.09008934
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07094872
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95783682
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.93620726
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.93525131
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89602774
34IGF1R_20145208_ChIP-Seq_DFB_Human1.88959928
35P300_19829295_ChIP-Seq_ESCs_Human1.84162073
36FUS_26573619_Chip-Seq_HEK293_Human1.81000385
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79486152
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.79256032
39SMAD4_21799915_ChIP-Seq_A2780_Human1.76612418
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70250322
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69396935
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69178205
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63900060
44ZNF274_21170338_ChIP-Seq_K562_Hela1.59958213
45RNF2_27304074_Chip-Seq_NSC_Mouse1.57454652
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55444928
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55101310
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53811415
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53702907
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52912263
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.52185904
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51805896
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.47822760
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46989397
55VDR_22108803_ChIP-Seq_LS180_Human1.42525811
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41358727
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41057288
58AR_25329375_ChIP-Seq_VCAP_Human1.38970568
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.37165108
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32213826
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.30217926
62STAT3_23295773_ChIP-Seq_U87_Human1.28694856
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28621819
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27963479
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25803375
66BCAT_22108803_ChIP-Seq_LS180_Human1.24148328
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23377493
68ER_23166858_ChIP-Seq_MCF-7_Human1.22156574
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21759664
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19867667
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19034239
72TCF4_23295773_ChIP-Seq_U87_Human1.18737909
73RUNX2_22187159_ChIP-Seq_PCA_Human1.17904538
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16727448
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15489618
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.14153959
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.13432593
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13093485
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12321233
80AHR_22903824_ChIP-Seq_MCF-7_Human1.11913384
81AR_19668381_ChIP-Seq_PC3_Human1.11912811
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11875336
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.11724517
84JUN_21703547_ChIP-Seq_K562_Human1.11301750
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.10715842
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09133863
87TP53_18474530_ChIP-ChIP_U2OS_Human1.08629242
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08160826
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.07961366
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07075000
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04715269
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04467312
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04467312
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04264614
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03925180
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03844329
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03727574
98EWS_26573619_Chip-Seq_HEK293_Human1.03515863
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02757810
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02215743
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.01836597
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01494846
103KDM2B_26808549_Chip-Seq_REH_Human1.00520369
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98677355
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.98501360
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.96864903
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95505888
108TP53_22573176_ChIP-Seq_HFKS_Human0.94993130
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.94389701
110GATA1_26923725_Chip-Seq_HPCs_Mouse0.93723314
111POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93664588
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.93090480
113TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92807688
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92530408
115LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92293254
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92165645
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.91443087
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90955330
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89434707
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89050753
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88566982
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87892580
123CBP_20019798_ChIP-Seq_JUKART_Human0.87892580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.66820571
2MP0004859_abnormal_synaptic_plasticity4.60390337
3MP0003635_abnormal_synaptic_transmissio3.62251135
4MP0004270_analgesia3.32488843
5MP0009046_muscle_twitch3.14160838
6MP0009745_abnormal_behavioral_response3.01750764
7MP0002822_catalepsy3.00167932
8MP0002063_abnormal_learning/memory/cond2.87104456
9MP0002064_seizures2.83549546
10MP0006276_abnormal_autonomic_nervous2.64273733
11MP0002572_abnormal_emotion/affect_behav2.62820375
12MP0001486_abnormal_startle_reflex2.58304131
13MP0002734_abnormal_mechanical_nocicepti2.55398855
14MP0002735_abnormal_chemical_nociception2.54280525
15MP0001968_abnormal_touch/_nociception2.50629564
16MP0000778_abnormal_nervous_system2.44586324
17MP0002272_abnormal_nervous_system2.37804207
18MP0002184_abnormal_innervation2.28272916
19MP0001188_hyperpigmentation2.25578429
20MP0005423_abnormal_somatic_nervous2.09268896
21MP0002067_abnormal_sensory_capabilities2.08285162
22MP0001440_abnormal_grooming_behavior2.07449805
23MP0002733_abnormal_thermal_nociception2.04264727
24MP0002837_dystrophic_cardiac_calcinosis2.03336169
25MP0005367_renal/urinary_system_phenotyp1.97322202
26MP0000516_abnormal_urinary_system1.97322202
27MP0001501_abnormal_sleep_pattern1.90372373
28MP0002557_abnormal_social/conspecific_i1.88673932
29MP0003011_delayed_dark_adaptation1.83930161
30MP0001984_abnormal_olfaction1.81788449
31MP0003890_abnormal_embryonic-extraembry1.78960148
32MP0009379_abnormal_foot_pigmentation1.77317620
33MP0004858_abnormal_nervous_system1.77002401
34MP0004811_abnormal_neuron_physiology1.75219873
35MP0004924_abnormal_behavior1.75206640
36MP0005386_behavior/neurological_phenoty1.75206640
37MP0002909_abnormal_adrenal_gland1.74387309
38MP0001970_abnormal_pain_threshold1.73094142
39MP0002736_abnormal_nociception_after1.72873430
40MP0000955_abnormal_spinal_cord1.72768855
41MP0001529_abnormal_vocalization1.62784179
42MP0001485_abnormal_pinna_reflex1.61018266
43MP0010386_abnormal_urinary_bladder1.56739003
44MP0002882_abnormal_neuron_morphology1.55637009
45MP0004133_heterotaxia1.54769007
46MP0003121_genomic_imprinting1.50284348
47MP0003329_amyloid_beta_deposits1.49507879
48MP0002638_abnormal_pupillary_reflex1.47786469
49MP0003787_abnormal_imprinting1.47679163
50MP0003879_abnormal_hair_cell1.46128593
51MP0001986_abnormal_taste_sensitivity1.41724092
52MP0009780_abnormal_chondrocyte_physiolo1.41271543
53MP0004233_abnormal_muscle_weight1.39201521
54MP0001502_abnormal_circadian_rhythm1.37896293
55MP0002066_abnormal_motor_capabilities/c1.37507106
56MP0003119_abnormal_digestive_system1.35950610
57MP0008569_lethality_at_weaning1.35442993
58MP0000049_abnormal_middle_ear1.34063678
59MP0005253_abnormal_eye_physiology1.33367242
60MP0004742_abnormal_vestibular_system1.30662948
61MP0000534_abnormal_ureter_morphology1.28927394
62MP0004142_abnormal_muscle_tone1.27940206
63MP0003122_maternal_imprinting1.27893799
64MP0005646_abnormal_pituitary_gland1.22709976
65MP0004885_abnormal_endolymph1.22285315
66MP0005623_abnormal_meninges_morphology1.21050566
67MP0002152_abnormal_brain_morphology1.20621001
68MP0000566_synostosis1.19794571
69MP0005645_abnormal_hypothalamus_physiol1.18788914
70MP0002102_abnormal_ear_morphology1.17840518
71MP0005171_absent_coat_pigmentation1.17491635
72MP0006292_abnormal_olfactory_placode1.16773434
73MP0002229_neurodegeneration1.16529923
74MP0006072_abnormal_retinal_apoptosis1.16143129
75MP0002234_abnormal_pharynx_morphology1.14475534
76MP0000631_abnormal_neuroendocrine_gland1.14385986
77MP0005551_abnormal_eye_electrophysiolog1.12727614
78MP0000751_myopathy1.10556363
79MP0002751_abnormal_autonomic_nervous1.07747259
80MP0002752_abnormal_somatic_nervous1.07390322
81MP0000026_abnormal_inner_ear1.03301607
82MP0001963_abnormal_hearing_physiology1.03225053
83MP0005187_abnormal_penis_morphology1.01573332
84MP0003252_abnormal_bile_duct1.00604031
85MP0004085_abnormal_heartbeat1.00541677
86MP0001299_abnormal_eye_distance/0.96869394
87MP0004215_abnormal_myocardial_fiber0.93270602
88MP0001905_abnormal_dopamine_level0.93157232
89MP0004484_altered_response_of0.91960275
90MP0008789_abnormal_olfactory_epithelium0.88830554
91MP0001177_atelectasis0.88472520
92MP0002069_abnormal_eating/drinking_beha0.87445151
93MP0003633_abnormal_nervous_system0.86950971
94MP0003937_abnormal_limbs/digits/tail_de0.85509421
95MP0004043_abnormal_pH_regulation0.84942294
96MP0000537_abnormal_urethra_morphology0.84501160
97MP0003935_abnormal_craniofacial_develop0.84157626
98MP0003283_abnormal_digestive_organ0.82449994
99MP0005248_abnormal_Harderian_gland0.82214861
100MP0001270_distended_abdomen0.82062053
101MP0003631_nervous_system_phenotype0.81630813
102MP0000427_abnormal_hair_cycle0.76375703
103MP0002876_abnormal_thyroid_physiology0.75111547
104MP0003137_abnormal_impulse_conducting0.75072065
105MP0003755_abnormal_palate_morphology0.74862013
106MP0003634_abnormal_glial_cell0.74808413
107MP0002081_perinatal_lethality0.74687104
108MP0002233_abnormal_nose_morphology0.73652580
109MP0003861_abnormal_nervous_system0.73512469
110MP0003632_abnormal_nervous_system0.71279015
111MP0005535_abnormal_body_temperature0.69969971
112MP0000569_abnormal_digit_pigmentation0.69706428
113MP0003115_abnormal_respiratory_system0.69619053
114MP0008961_abnormal_basal_metabolism0.67561505
115MP0000383_abnormal_hair_follicle0.67128932
116MP0005195_abnormal_posterior_eye0.66248372
117MP0003938_abnormal_ear_development0.66017382
118MP0005379_endocrine/exocrine_gland_phen0.65608688
119MP0004145_abnormal_muscle_electrophysio0.65393700
120MP0002082_postnatal_lethality0.64816936
121MP0010770_preweaning_lethality0.64816936
122MP0001943_abnormal_respiration0.63107331
123MP0002090_abnormal_vision0.61768785
124MP0001664_abnormal_digestion0.60107589
125MP0010769_abnormal_survival0.59574404
126MP0002693_abnormal_pancreas_physiology0.57372303
127MP0001944_abnormal_pancreas_morphology0.57224485
128MP0010768_mortality/aging0.55923273
129MP0008872_abnormal_physiological_respon0.54717108
130MP0002653_abnormal_ependyma_morphology0.54067049
131MP0005394_taste/olfaction_phenotype0.53327594
132MP0005499_abnormal_olfactory_system0.53327594

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.07016366
2Focal seizures (HP:0007359)5.01689631
3Atonic seizures (HP:0010819)4.97560628
4Absence seizures (HP:0002121)4.70386584
5Epileptic encephalopathy (HP:0200134)4.70324958
6Hyperventilation (HP:0002883)4.65020187
7Febrile seizures (HP:0002373)4.49631376
8Visual hallucinations (HP:0002367)4.27466996
9Myokymia (HP:0002411)4.04078066
10Dialeptic seizures (HP:0011146)4.02748293
11Broad-based gait (HP:0002136)3.97244435
12Generalized tonic-clonic seizures (HP:0002069)3.83397692
13Supranuclear gaze palsy (HP:0000605)3.81683465
14Retinal dysplasia (HP:0007973)3.79728747
15Dysmetric saccades (HP:0000641)3.65465177
16Lissencephaly (HP:0001339)3.62444918
17Progressive cerebellar ataxia (HP:0002073)3.49754601
18Failure to thrive in infancy (HP:0001531)3.49058188
19Type II lissencephaly (HP:0007260)3.36099423
20Epileptiform EEG discharges (HP:0011182)3.21208216
21Pheochromocytoma (HP:0002666)3.14307805
22EEG with generalized epileptiform discharges (HP:0011198)3.08090890
23Amblyopia (HP:0000646)3.07770674
24Impaired social interactions (HP:0000735)3.03141589
25Abnormal social behavior (HP:0012433)3.03141589
26Poor eye contact (HP:0000817)3.01620062
27Impaired vibratory sensation (HP:0002495)3.00941187
28Drooling (HP:0002307)2.98439018
29Excessive salivation (HP:0003781)2.98439018
30Gaze-evoked nystagmus (HP:0000640)2.95440648
31Hypsarrhythmia (HP:0002521)2.91461094
32Dysdiadochokinesis (HP:0002075)2.87129571
33Gait imbalance (HP:0002141)2.80398317
34Neurofibrillary tangles (HP:0002185)2.77657478
35Neuroendocrine neoplasm (HP:0100634)2.74443001
36Truncal ataxia (HP:0002078)2.73062769
37Chorioretinal atrophy (HP:0000533)2.68142256
38Cerebral inclusion bodies (HP:0100314)2.67780477
39Aplasia/Hypoplasia of the brainstem (HP:0007362)2.63769390
40Hypoplasia of the brainstem (HP:0002365)2.63769390
41Pendular nystagmus (HP:0012043)2.63400946
42Action tremor (HP:0002345)2.61084068
43Exotropia (HP:0000577)2.59683607
44Ankle clonus (HP:0011448)2.58884161
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58303973
46Abnormality of macular pigmentation (HP:0008002)2.57663455
47Abnormality of the corticospinal tract (HP:0002492)2.56919562
48Abnormality of binocular vision (HP:0011514)2.55815093
49Diplopia (HP:0000651)2.55815093
50Mutism (HP:0002300)2.51986578
51Rib fusion (HP:0000902)2.48102942
52Hemiparesis (HP:0001269)2.47299651
53Stereotypic behavior (HP:0000733)2.45362450
54Urinary bladder sphincter dysfunction (HP:0002839)2.44947746
55Anxiety (HP:0000739)2.42945640
56Nephrogenic diabetes insipidus (HP:0009806)2.42739661
57Protruding tongue (HP:0010808)2.40817422
58Prolonged QT interval (HP:0001657)2.37249977
59Abnormal eating behavior (HP:0100738)2.36530971
60Absent speech (HP:0001344)2.35460873
61Impaired smooth pursuit (HP:0007772)2.35310725
62Increased circulating renin level (HP:0000848)2.33695620
63Polyphagia (HP:0002591)2.32678165
64Spastic gait (HP:0002064)2.32409557
65Spastic tetraplegia (HP:0002510)2.29959909
66Amyotrophic lateral sclerosis (HP:0007354)2.28367054
67Impaired vibration sensation in the lower limbs (HP:0002166)2.27404739
68Fibular aplasia (HP:0002990)2.26171801
69Dysmetria (HP:0001310)2.25577159
70Pachygyria (HP:0001302)2.25548453
71Decreased muscle mass (HP:0003199)2.23689153
72Limb dystonia (HP:0002451)2.22747432
73Split foot (HP:0001839)2.22201999
74Papillary thyroid carcinoma (HP:0002895)2.22064573
75Blue irides (HP:0000635)2.20881121
76Akinesia (HP:0002304)2.20196399
77Generalized myoclonic seizures (HP:0002123)2.18676389
78Ventricular fibrillation (HP:0001663)2.16962564
79Cerebellar dysplasia (HP:0007033)2.16659659
80Intellectual disability, severe (HP:0010864)2.15168586
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.15116322
82Absent/shortened dynein arms (HP:0200106)2.15116322
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.13112733
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13112733
85Renal hypoplasia (HP:0000089)2.13092451
86Poor coordination (HP:0002370)2.13042029
87Status epilepticus (HP:0002133)2.11748380
88Abnormality of midbrain morphology (HP:0002418)2.10802209
89Molar tooth sign on MRI (HP:0002419)2.10802209
90Intestinal atresia (HP:0011100)2.09978781
91Depression (HP:0000716)2.09029999
92Medial flaring of the eyebrow (HP:0010747)2.08307588
93Bifid tongue (HP:0010297)2.05333210
94Vaginal atresia (HP:0000148)2.04547369
95Esotropia (HP:0000565)2.03668523
96Congenital primary aphakia (HP:0007707)2.02806207
97Urinary urgency (HP:0000012)2.02353705
98Hypoventilation (HP:0002791)2.01698603
99Agitation (HP:0000713)2.01192819
100Scanning speech (HP:0002168)2.00861604
101Thyroid-stimulating hormone excess (HP:0002925)2.00522894
102Genital tract atresia (HP:0001827)2.00482004
103Inappropriate behavior (HP:0000719)2.00283329
104Abnormality of salivation (HP:0100755)1.97999585
105Complete atrioventricular canal defect (HP:0001674)1.97420000
106Gastroesophageal reflux (HP:0002020)1.95716209
107Postural instability (HP:0002172)1.95402754
108Genetic anticipation (HP:0003743)1.94912591
109Vitreoretinal degeneration (HP:0000655)1.94786742
110Psychosis (HP:0000709)1.94435267
111Occipital encephalocele (HP:0002085)1.92756742
112Bradykinesia (HP:0002067)1.92596740
113Specific learning disability (HP:0001328)1.89585708
114Autism (HP:0000717)1.89426038
115Narrow forehead (HP:0000341)1.88441746
116Abnormality of ocular smooth pursuit (HP:0000617)1.88098498
117Increased serum pyruvate (HP:0003542)1.87938727
118Abnormality of glycolysis (HP:0004366)1.87938727
119Abnormality of the lower motor neuron (HP:0002366)1.87935808
120Thickened helices (HP:0000391)1.86500572
121Inability to walk (HP:0002540)1.86042988
122Torticollis (HP:0000473)1.85151269
123Thyroid carcinoma (HP:0002890)1.84992597
124Hepatoblastoma (HP:0002884)1.84680713
125Focal dystonia (HP:0004373)1.83688879
126Oligodactyly (hands) (HP:0001180)1.83033614
127Cutaneous finger syndactyly (HP:0010554)1.82163940
128Syncope (HP:0001279)1.81134963
129True hermaphroditism (HP:0010459)1.80952783
130Narrow nasal bridge (HP:0000446)1.80947105
131Generalized hypopigmentation of hair (HP:0011358)1.79789311
132Congenital stationary night blindness (HP:0007642)1.79430770
133Craniofacial dystonia (HP:0012179)1.78940259
134Abnormal EKG (HP:0003115)1.78883399
135Morphological abnormality of the pyramidal tract (HP:0002062)1.77805423
136Abnormality of calcium-phosphate metabolism (HP:0100530)1.77719642
137Polymicrogyria (HP:0002126)1.77066506
138Lower limb muscle weakness (HP:0007340)1.76358807
139Limb ataxia (HP:0002070)1.75795937
140Insidious onset (HP:0003587)1.75107030
141Termporal pattern (HP:0011008)1.75107030
142Postnatal microcephaly (HP:0005484)1.72501707
143Hypoplasia of the corpus callosum (HP:0002079)1.70933233
144Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70046217
145Abnormality of the aortic arch (HP:0012303)1.69127268
146Postaxial hand polydactyly (HP:0001162)1.68841401
147Medulloblastoma (HP:0002885)1.66929219
148Renovascular hypertension (HP:0100817)1.66655967
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66121103
150Humeroradial synostosis (HP:0003041)1.65861208
151Synostosis involving the elbow (HP:0003938)1.65861208
152Cutaneous syndactyly (HP:0012725)1.65382794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.16535162
2NTRK34.35235257
3CASK3.82514884
4MAP3K93.47236880
5EPHA43.10999209
6TRIM282.78146819
7TNIK2.65515438
8MAP3K42.56667781
9NTRK22.48171410
10MAP2K72.32560059
11SIK22.23015770
12TESK22.16452548
13MAPK132.11849533
14MAP4K22.03449329
15MINK11.87104071
16SIK31.78549318
17PLK21.77384939
18CSNK1G31.73177793
19PNCK1.72400566
20CSNK1A1L1.70934830
21NTRK11.64572321
22NME11.63704654
23PAK61.62878958
24DYRK21.61831820
25DAPK21.59906439
26AKT31.56055981
27UHMK11.54585533
28PRKD31.52220014
29GRK51.50640927
30MAP2K41.49591289
31INSRR1.45186829
32CSNK1G11.40872338
33PHKG11.39706736
34PHKG21.39706736
35CDK51.35972861
36PRPF4B1.34094255
37KSR11.31400464
38TESK11.29505642
39STK38L1.23992107
40RIPK41.19101384
41PRKCG1.17247220
42MAP3K121.16040685
43GRK11.11367927
44STK161.06459575
45MAPKAPK51.03638749
46CDK191.03549683
47CAMK2A0.98306506
48LIMK10.98134858
49FGR0.96684178
50ZAK0.96483081
51SGK2230.92493989
52SGK4940.92493989
53CAMK2B0.91945219
54PKN10.90467300
55RET0.90011593
56EPHA30.88928101
57MARK20.88262490
58OXSR10.87314901
59MKNK20.86942043
60PRKCE0.86698309
61MKNK10.85052611
62DYRK1A0.84810144
63TSSK60.84495518
64PAK30.84330875
65DAPK10.83902629
66ERBB30.83494745
67ERBB20.81425972
68BRD40.80895905
69SGK20.79695647
70FES0.77761244
71FGFR20.77245217
72CDK180.76749082
73MAP3K60.76509474
74KSR20.74993087
75CDK150.74160027
76MAPK120.72730687
77CDK140.69727700
78CDK11A0.64328052
79MAP3K70.62964702
80DYRK1B0.62411251
81HIPK20.62066282
82LATS10.60784520
83ADRBK10.60331043
84CSNK1D0.59255641
85CAMK10.57642999
86BMPR1B0.57197352
87SIK10.56599487
88ATR0.55929407
89FRK0.55560944
90CAMK2D0.55197817
91CSNK1G20.54754259
92PINK10.54145979
93SGK10.53791126
94ADRBK20.53258166
95MAP3K20.52390384
96RPS6KA20.52269568
97STK390.50209519
98FGFR30.49441288
99PRKCZ0.48525256
100CAMKK20.48393705
101CDK80.47488427
102EPHB20.47374856
103GRK70.46311477
104PRKCH0.45863104
105FER0.45536897
106PKN20.44110440
107CSNK1A10.43538958
108TAF10.43318014
109CAMKK10.43109745
110PRKCB0.41839007
111BMPR20.41156051
112LATS20.40590394
113ERBB40.39416416
114WNK30.39178730
115ROCK20.39047476
116TYRO30.38672567
117MAPK90.38319280
118PRKG10.37856080
119CAMK40.36918201
120PRKACA0.36237842
121BCR0.35910225
122RPS6KA30.35724796
123IRAK20.35067549
124PRKAA10.34947977
125SGK30.34221535
126ALK0.32539208
127PRKDC0.31237854
128CSNK1E0.30843522
129PRKACB0.30838786
130PIK3CA0.30727760
131GSK3B0.30219956
132STK380.30132046
133STK110.30104782
134PRKD20.29970155
135FYN0.28602620
136PDK10.28562689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.36491659
2Synaptic vesicle cycle_Homo sapiens_hsa047213.08834107
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.99389161
4GABAergic synapse_Homo sapiens_hsa047272.83008742
5Glutamatergic synapse_Homo sapiens_hsa047242.64527459
6Morphine addiction_Homo sapiens_hsa050322.59457107
7Circadian entrainment_Homo sapiens_hsa047132.57364473
8Amphetamine addiction_Homo sapiens_hsa050312.33900657
9Long-term potentiation_Homo sapiens_hsa047202.31312305
10Dopaminergic synapse_Homo sapiens_hsa047282.25945249
11Insulin secretion_Homo sapiens_hsa049112.16729399
12Olfactory transduction_Homo sapiens_hsa047402.12510294
13Taste transduction_Homo sapiens_hsa047422.09072161
14Collecting duct acid secretion_Homo sapiens_hsa049662.02974441
15Serotonergic synapse_Homo sapiens_hsa047261.99080170
16Salivary secretion_Homo sapiens_hsa049701.88425135
17Cholinergic synapse_Homo sapiens_hsa047251.80236600
18Sulfur metabolism_Homo sapiens_hsa009201.78725528
19Renin secretion_Homo sapiens_hsa049241.76259790
20Cocaine addiction_Homo sapiens_hsa050301.74832161
21Axon guidance_Homo sapiens_hsa043601.70274079
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67007510
23Steroid biosynthesis_Homo sapiens_hsa001001.62299474
24Vibrio cholerae infection_Homo sapiens_hsa051101.62056232
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61594888
26Long-term depression_Homo sapiens_hsa047301.60085542
27Oxidative phosphorylation_Homo sapiens_hsa001901.55009188
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.51947209
29Propanoate metabolism_Homo sapiens_hsa006401.49663855
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48405421
31Phototransduction_Homo sapiens_hsa047441.43158106
32Gastric acid secretion_Homo sapiens_hsa049711.38778074
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36744211
34Alzheimers disease_Homo sapiens_hsa050101.35687784
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30275745
36Type II diabetes mellitus_Homo sapiens_hsa049301.29034570
37Oxytocin signaling pathway_Homo sapiens_hsa049211.28223293
38Calcium signaling pathway_Homo sapiens_hsa040201.26585399
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22883459
40Cardiac muscle contraction_Homo sapiens_hsa042601.21852626
41Gap junction_Homo sapiens_hsa045401.17615893
42Hippo signaling pathway_Homo sapiens_hsa043901.14954658
43Parkinsons disease_Homo sapiens_hsa050121.12835888
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.12394237
45GnRH signaling pathway_Homo sapiens_hsa049121.11181786
46cAMP signaling pathway_Homo sapiens_hsa040241.03345262
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01394969
48Butanoate metabolism_Homo sapiens_hsa006500.99071425
49Selenocompound metabolism_Homo sapiens_hsa004500.96222425
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95873564
51Melanogenesis_Homo sapiens_hsa049160.95864841
52Estrogen signaling pathway_Homo sapiens_hsa049150.95812036
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94626369
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94144817
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92616092
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92559941
57ErbB signaling pathway_Homo sapiens_hsa040120.92430407
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.91065426
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90387113
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87155715
61Hedgehog signaling pathway_Homo sapiens_hsa043400.86131910
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82206767
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81371626
64Huntingtons disease_Homo sapiens_hsa050160.81344484
65Glioma_Homo sapiens_hsa052140.80375799
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80300596
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78201219
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74971658
69Circadian rhythm_Homo sapiens_hsa047100.74820890
70Dilated cardiomyopathy_Homo sapiens_hsa054140.74372068
71Pancreatic secretion_Homo sapiens_hsa049720.72253156
72ABC transporters_Homo sapiens_hsa020100.71504320
73Fatty acid biosynthesis_Homo sapiens_hsa000610.70221140
74Alcoholism_Homo sapiens_hsa050340.69644706
75mRNA surveillance pathway_Homo sapiens_hsa030150.68776633
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67404561
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.65901759
78Pyruvate metabolism_Homo sapiens_hsa006200.65571670
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64265261
80Glucagon signaling pathway_Homo sapiens_hsa049220.62682066
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59230201
82Fanconi anemia pathway_Homo sapiens_hsa034600.58831720
83Dorso-ventral axis formation_Homo sapiens_hsa043200.58269254
84Fatty acid metabolism_Homo sapiens_hsa012120.57108370
85AMPK signaling pathway_Homo sapiens_hsa041520.56302676
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56071961
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53865523
88Basal cell carcinoma_Homo sapiens_hsa052170.52558143
89Ras signaling pathway_Homo sapiens_hsa040140.52556568
90Thyroid hormone synthesis_Homo sapiens_hsa049180.52270522
91Oocyte meiosis_Homo sapiens_hsa041140.51484975
92Phagosome_Homo sapiens_hsa041450.51253891
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49675902
94Ether lipid metabolism_Homo sapiens_hsa005650.49110991
95Arginine and proline metabolism_Homo sapiens_hsa003300.48193685
96beta-Alanine metabolism_Homo sapiens_hsa004100.48150618
97MAPK signaling pathway_Homo sapiens_hsa040100.47827460
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47522325
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46991227
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44772322
101Choline metabolism in cancer_Homo sapiens_hsa052310.44220681
102Wnt signaling pathway_Homo sapiens_hsa043100.43902137
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43856266
104Type I diabetes mellitus_Homo sapiens_hsa049400.43408222
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41962795
106Vitamin digestion and absorption_Homo sapiens_hsa049770.41422628
107Rap1 signaling pathway_Homo sapiens_hsa040150.41331138
108Protein export_Homo sapiens_hsa030600.41280573
109Tryptophan metabolism_Homo sapiens_hsa003800.39347863
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39268726
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39126776
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37992984
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.37753077
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37318566
115TGF-beta signaling pathway_Homo sapiens_hsa043500.37310642
116Renal cell carcinoma_Homo sapiens_hsa052110.36826726
117Prion diseases_Homo sapiens_hsa050200.36622394
118Ovarian steroidogenesis_Homo sapiens_hsa049130.35990331
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34510100
120Tight junction_Homo sapiens_hsa045300.34471323
121Rheumatoid arthritis_Homo sapiens_hsa053230.34106798
122Retinol metabolism_Homo sapiens_hsa008300.33456112
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.32532786
124Fat digestion and absorption_Homo sapiens_hsa049750.31904155
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31319534
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30754267
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29144029
128Colorectal cancer_Homo sapiens_hsa052100.28662261
129Insulin signaling pathway_Homo sapiens_hsa049100.26902619
130Fatty acid elongation_Homo sapiens_hsa000620.26323954
131VEGF signaling pathway_Homo sapiens_hsa043700.25354655
132Endometrial cancer_Homo sapiens_hsa052130.24964871
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.24779596
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23187022

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