PCDHA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.19191002
2vocalization behavior (GO:0071625)6.02940391
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.93580897
4neuron cell-cell adhesion (GO:0007158)5.89752568
5behavioral response to nicotine (GO:0035095)5.82284691
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.14987985
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11803591
8synaptic vesicle maturation (GO:0016188)5.08823714
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08746028
10nucleobase catabolic process (GO:0046113)5.00751962
11locomotory exploration behavior (GO:0035641)4.93185763
12synaptic vesicle exocytosis (GO:0016079)4.92786957
13layer formation in cerebral cortex (GO:0021819)4.91860326
14protein localization to synapse (GO:0035418)4.91297105
15regulation of synaptic vesicle exocytosis (GO:2000300)4.86748520
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.73050505
17glutamate secretion (GO:0014047)4.67426335
18regulation of glutamate receptor signaling pathway (GO:1900449)4.57341355
19regulation of synapse structural plasticity (GO:0051823)4.39231170
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.36328225
21cell migration in hindbrain (GO:0021535)4.35574493
22postsynaptic membrane organization (GO:0001941)4.33933709
23fucose catabolic process (GO:0019317)4.27832911
24L-fucose metabolic process (GO:0042354)4.27832911
25L-fucose catabolic process (GO:0042355)4.27832911
26central nervous system projection neuron axonogenesis (GO:0021952)4.26032290
27neuron recognition (GO:0008038)4.25351887
28regulation of synaptic vesicle transport (GO:1902803)4.18822420
29dendrite morphogenesis (GO:0048813)4.14672882
30exploration behavior (GO:0035640)4.12861731
31synaptic transmission, glutamatergic (GO:0035249)4.01558066
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98405667
33neurotransmitter-gated ion channel clustering (GO:0072578)3.97473583
34neurotransmitter secretion (GO:0007269)3.96438701
35regulation of neuronal synaptic plasticity (GO:0048168)3.88887589
36proline transport (GO:0015824)3.88598193
37platelet dense granule organization (GO:0060155)3.84917021
38transmission of nerve impulse (GO:0019226)3.84787266
39dendritic spine morphogenesis (GO:0060997)3.84749149
40axonal fasciculation (GO:0007413)3.84658837
41glutamate receptor signaling pathway (GO:0007215)3.80114294
42positive regulation of synapse maturation (GO:0090129)3.75725231
43response to pheromone (GO:0019236)3.70983315
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70866794
45neuron-neuron synaptic transmission (GO:0007270)3.70326398
46presynaptic membrane assembly (GO:0097105)3.66149082
47cerebellar Purkinje cell layer development (GO:0021680)3.64671227
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64628243
49gamma-aminobutyric acid transport (GO:0015812)3.55485433
50synapse assembly (GO:0007416)3.51523237
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.51361047
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50017671
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49147045
54DNA deamination (GO:0045006)3.48653646
55kynurenine metabolic process (GO:0070189)3.47551886
56regulation of neurotransmitter secretion (GO:0046928)3.46174670
57positive regulation of membrane potential (GO:0045838)3.45236575
58synaptic vesicle endocytosis (GO:0048488)3.43658445
59indole-containing compound catabolic process (GO:0042436)3.43427957
60indolalkylamine catabolic process (GO:0046218)3.43427957
61tryptophan catabolic process (GO:0006569)3.43427957
62cellular ketone body metabolic process (GO:0046950)3.42849072
63innervation (GO:0060384)3.41486902
64regulation of postsynaptic membrane potential (GO:0060078)3.41446551
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40295848
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40180142
67cerebellar granule cell differentiation (GO:0021707)3.39095753
68neuronal action potential propagation (GO:0019227)3.36316972
69regulation of dendritic spine morphogenesis (GO:0061001)3.36112706
70protein-cofactor linkage (GO:0018065)3.35466690
71negative regulation of telomere maintenance (GO:0032205)3.34077048
72indolalkylamine metabolic process (GO:0006586)3.32570143
73presynaptic membrane organization (GO:0097090)3.31426176
74cellular potassium ion homeostasis (GO:0030007)3.30684918
75neural tube formation (GO:0001841)3.29103806
76water-soluble vitamin biosynthetic process (GO:0042364)3.27762833
77central nervous system neuron axonogenesis (GO:0021955)3.26232980
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.24302817
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23714199
80kidney morphogenesis (GO:0060993)3.22720498
81negative regulation of microtubule polymerization (GO:0031115)3.22671545
82cell communication by electrical coupling (GO:0010644)3.22617116
83cerebellar Purkinje cell differentiation (GO:0021702)3.19006574
84neuronal action potential (GO:0019228)3.17892396
85positive regulation of neurotransmitter secretion (GO:0001956)3.17550181
86long-term memory (GO:0007616)3.16663367
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.15495988
88organelle transport along microtubule (GO:0072384)3.15115072
89neurotransmitter transport (GO:0006836)3.14269957
90positive regulation of synapse assembly (GO:0051965)3.14089487
91negative regulation of mast cell activation (GO:0033004)3.13919434
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13049949
93epithelial cilium movement (GO:0003351)3.12587576
94intraspecies interaction between organisms (GO:0051703)3.12401366
95social behavior (GO:0035176)3.12401366
96regulation of synaptic plasticity (GO:0048167)3.12250115
97protein localization to cilium (GO:0061512)3.12214206
98membrane hyperpolarization (GO:0060081)3.09611314
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09054482
100regulation of vesicle fusion (GO:0031338)3.08584587
101ketone body metabolic process (GO:1902224)3.08570422
102regulation of neurotransmitter transport (GO:0051588)3.08085667
103behavioral response to ethanol (GO:0048149)3.08034088
104synapse organization (GO:0050808)3.06700523
105learning (GO:0007612)3.06476098
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06080367
107membrane depolarization (GO:0051899)3.05676368
108protein polyglutamylation (GO:0018095)3.04680506
109neuronal ion channel clustering (GO:0045161)3.03689645
110regulation of synaptic transmission, glutamatergic (GO:0051966)3.03315145
111auditory behavior (GO:0031223)3.02706756
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02576040
113primary amino compound metabolic process (GO:1901160)3.02495473
114vesicle transport along microtubule (GO:0047496)3.02479402
115negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01097553
116adult walking behavior (GO:0007628)3.01043084
117long-term synaptic potentiation (GO:0060291)2.99052971
118dopamine transport (GO:0015872)2.98823381
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97952921
120axoneme assembly (GO:0035082)2.97530027
121neuromuscular synaptic transmission (GO:0007274)2.97216280
122prepulse inhibition (GO:0060134)2.96349236
123clathrin coat assembly (GO:0048268)2.96168221
124positive regulation of dendritic spine development (GO:0060999)2.95859884
125detection of light stimulus involved in sensory perception (GO:0050962)2.95699930
126detection of light stimulus involved in visual perception (GO:0050908)2.95699930
127positive regulation of neurotransmitter transport (GO:0051590)2.95493994
128dendrite development (GO:0016358)2.95001562
129regulation of action potential (GO:0098900)2.93875114
130membrane depolarization during action potential (GO:0086010)2.92462880
131tryptophan metabolic process (GO:0006568)2.92433868
132negative regulation of dendrite development (GO:2000171)2.91320180
133activation of protein kinase A activity (GO:0034199)2.91161708
134indole-containing compound metabolic process (GO:0042430)2.86515448
135regulation of glucokinase activity (GO:0033131)2.84875139
136regulation of hexokinase activity (GO:1903299)2.84875139
137serotonin metabolic process (GO:0042428)2.84674039
138respiratory chain complex IV assembly (GO:0008535)2.81736443
139synaptic transmission, cholinergic (GO:0007271)2.80545000
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.80226507
141NADH dehydrogenase complex assembly (GO:0010257)2.80226507
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80226507
143reflex (GO:0060004)2.79740713
144preassembly of GPI anchor in ER membrane (GO:0016254)2.78484860
145regulation of cilium movement (GO:0003352)2.78076720
146cornea development in camera-type eye (GO:0061303)2.76687288
147piRNA metabolic process (GO:0034587)2.76423763
148nonmotile primary cilium assembly (GO:0035058)2.75444966
149startle response (GO:0001964)2.74544058
150ubiquinone biosynthetic process (GO:0006744)2.74220742
151cilium morphogenesis (GO:0060271)2.73123090
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72152992
153protein complex biogenesis (GO:0070271)2.71131968
154mannosylation (GO:0097502)2.69805819
155rRNA catabolic process (GO:0016075)2.67351569
156ubiquinone metabolic process (GO:0006743)2.65600995
157alanine transport (GO:0032328)2.62499048
158sulfation (GO:0051923)2.62480941
159retinal cone cell development (GO:0046549)2.61279100
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61273000
161cilium organization (GO:0044782)2.60444769
162cilium movement (GO:0003341)2.58746067
163negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57921294
164cilium assembly (GO:0042384)2.55796876
165inner ear receptor stereocilium organization (GO:0060122)2.55691043
166retinal ganglion cell axon guidance (GO:0031290)2.55519567
167regulation of neurotransmitter uptake (GO:0051580)2.55502800
168positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.54407974
169spinal cord motor neuron differentiation (GO:0021522)2.53994322
170regulation of telomere maintenance (GO:0032204)2.51529223
171inositol phosphate catabolic process (GO:0071545)2.50611603
172auditory receptor cell stereocilium organization (GO:0060088)2.50470409
173neuron fate determination (GO:0048664)2.50134576
174photoreceptor cell development (GO:0042461)2.48157744
175mitochondrial respiratory chain complex assembly (GO:0033108)2.45293223
176glycerophospholipid catabolic process (GO:0046475)2.44857872
177negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.44456525
178negative regulation of translation, ncRNA-mediated (GO:0040033)2.44456525
179regulation of translation, ncRNA-mediated (GO:0045974)2.44456525
180GPI anchor metabolic process (GO:0006505)2.43953307
181photoreceptor cell maintenance (GO:0045494)2.41816715
182positive regulation of sodium ion transmembrane transport (GO:1902307)2.41144443
183positive regulation of action potential (GO:0045760)2.40073330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.92495004
2GBX2_23144817_ChIP-Seq_PC3_Human3.95083674
3VDR_22108803_ChIP-Seq_LS180_Human3.07485011
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07174522
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90062267
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86455119
7REST_21632747_ChIP-Seq_MESCs_Mouse2.71937554
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.71174104
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65691345
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65691345
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55591614
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54478029
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.53627117
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52177891
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47741506
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47204982
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41353968
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39559010
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35338713
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33822310
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32481002
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.28924048
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.23895496
24DROSHA_22980978_ChIP-Seq_HELA_Human2.23558290
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.22135358
26AR_21572438_ChIP-Seq_LNCaP_Human2.21926036
27TAF15_26573619_Chip-Seq_HEK293_Human2.19627806
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.16477940
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.15060148
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.13630986
31EWS_26573619_Chip-Seq_HEK293_Human2.11312583
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00301575
33IGF1R_20145208_ChIP-Seq_DFB_Human1.97685204
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90135468
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82132622
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80639210
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80623049
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79725727
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78962665
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73294837
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.71834339
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69195734
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65655110
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65384368
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61925360
46ZNF274_21170338_ChIP-Seq_K562_Hela1.60031586
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57877272
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57171445
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55554398
50SMAD4_21799915_ChIP-Seq_A2780_Human1.54837777
51CBP_20019798_ChIP-Seq_JUKART_Human1.48847929
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48847929
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46245467
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45637349
55IRF1_19129219_ChIP-ChIP_H3396_Human1.44978292
56RNF2_27304074_Chip-Seq_NSC_Mouse1.42997038
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42029946
58TP53_22573176_ChIP-Seq_HFKS_Human1.41355090
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.38916922
60P300_19829295_ChIP-Seq_ESCs_Human1.38305264
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37671571
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37188455
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36345744
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.35460074
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35389999
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.35200351
67MYC_18940864_ChIP-ChIP_HL60_Human1.34886123
68AR_25329375_ChIP-Seq_VCAP_Human1.34650791
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.34479916
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33438831
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33163446
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31921632
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30999079
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30850294
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.29518877
76TCF4_22108803_ChIP-Seq_LS180_Human1.28785217
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.27772859
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.27194311
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.27000087
80NANOG_19829295_ChIP-Seq_ESCs_Human1.26402441
81SOX2_19829295_ChIP-Seq_ESCs_Human1.26402441
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24414358
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.23419351
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23419351
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23079369
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.22235357
87STAT3_23295773_ChIP-Seq_U87_Human1.21972875
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21608137
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20599065
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20124862
91AR_19668381_ChIP-Seq_PC3_Human1.19648015
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.18985312
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17510510
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17062624
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.15732518
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15641219
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.13876894
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13403083
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.12858635
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12781745
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.12472800
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.12383073
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11787276
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11534235
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11167801
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.10345479
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10063809
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09414553
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08801676
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08584108
111GATA3_21878914_ChIP-Seq_MCF-7_Human1.08152050
112AR_20517297_ChIP-Seq_VCAP_Human1.07883058
113P53_22387025_ChIP-Seq_ESCs_Mouse1.07475884
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.06783228
115NCOR_22424771_ChIP-Seq_293T_Human1.06525667
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06331179
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05623440
118TCF4_23295773_ChIP-Seq_U87_Human1.03185704
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02979956
120JUN_21703547_ChIP-Seq_K562_Human1.02771768
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.02551020
122AHR_22903824_ChIP-Seq_MCF-7_Human1.02181062
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01707809
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01100857
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00786862
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00511313
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99898064
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99503438
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99503438
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98651025
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.98088856
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.97860394
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97258074
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96877229
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96700904
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96580646
137RUNX2_22187159_ChIP-Seq_PCA_Human0.96450786
138FUS_26573619_Chip-Seq_HEK293_Human0.95792906
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.95627670
140POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95227075
141HOXB7_26014856_ChIP-Seq_BT474_Human0.95223384
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.94564069
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94558653
144BCAT_22108803_ChIP-Seq_LS180_Human0.94077948
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93110756
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92291425
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91850442
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89991236
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89484954
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89175275
151SMAD_19615063_ChIP-ChIP_OVARY_Human0.88096612
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87509489
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86628023
154ER_23166858_ChIP-Seq_MCF-7_Human0.86284616
155KDM2B_26808549_Chip-Seq_K562_Human0.85765035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79719464
2MP0003880_abnormal_central_pattern4.24380272
3MP0003635_abnormal_synaptic_transmissio3.86273829
4MP0004270_analgesia3.82880468
5MP0002063_abnormal_learning/memory/cond3.27457364
6MP0009745_abnormal_behavioral_response3.08564205
7MP0001968_abnormal_touch/_nociception2.99156355
8MP0002734_abnormal_mechanical_nocicepti2.90318360
9MP0005423_abnormal_somatic_nervous2.85021741
10MP0002064_seizures2.78007802
11MP0008877_abnormal_DNA_methylation2.62967525
12MP0002572_abnormal_emotion/affect_behav2.60555876
13MP0002735_abnormal_chemical_nociception2.57263343
14MP0001440_abnormal_grooming_behavior2.47764096
15MP0000778_abnormal_nervous_system2.47381871
16MP0009046_muscle_twitch2.42708750
17MP0002736_abnormal_nociception_after2.37755793
18MP0003195_calcinosis2.36057957
19MP0001984_abnormal_olfaction2.35393288
20MP0004858_abnormal_nervous_system2.35213369
21MP0001501_abnormal_sleep_pattern2.30983168
22MP0002272_abnormal_nervous_system2.29460525
23MP0005645_abnormal_hypothalamus_physiol2.27404605
24MP0002184_abnormal_innervation2.26769398
25MP0002733_abnormal_thermal_nociception2.19984295
26MP0006276_abnormal_autonomic_nervous2.18572575
27MP0010386_abnormal_urinary_bladder2.16457076
28MP0001486_abnormal_startle_reflex2.15341316
29MP0001970_abnormal_pain_threshold2.04418637
30MP0002067_abnormal_sensory_capabilities1.99541148
31MP0003122_maternal_imprinting1.92274689
32MP0002557_abnormal_social/conspecific_i1.92133029
33MP0003136_yellow_coat_color1.86691103
34MP0004147_increased_porphyrin_level1.86206148
35MP0006292_abnormal_olfactory_placode1.85131439
36MP0004811_abnormal_neuron_physiology1.84803659
37MP0000955_abnormal_spinal_cord1.81070808
38MP0003329_amyloid_beta_deposits1.76448775
39MP0004133_heterotaxia1.72291066
40MP0009780_abnormal_chondrocyte_physiolo1.70157012
41MP0001485_abnormal_pinna_reflex1.69976257
42MP0003646_muscle_fatigue1.67019584
43MP0000427_abnormal_hair_cycle1.64210979
44MP0002876_abnormal_thyroid_physiology1.61999662
45MP0002938_white_spotting1.60884167
46MP0001502_abnormal_circadian_rhythm1.60469263
47MP0004924_abnormal_behavior1.58682192
48MP0005386_behavior/neurological_phenoty1.58682192
49MP0000569_abnormal_digit_pigmentation1.58587260
50MP0005646_abnormal_pituitary_gland1.58444268
51MP0005174_abnormal_tail_pigmentation1.58297107
52MP0003879_abnormal_hair_cell1.58084168
53MP0002882_abnormal_neuron_morphology1.55546925
54MP0003011_delayed_dark_adaptation1.52424372
55MP0008569_lethality_at_weaning1.51086826
56MP0000372_irregular_coat_pigmentation1.50436617
57MP0001529_abnormal_vocalization1.45738327
58MP0002638_abnormal_pupillary_reflex1.44513519
59MP0002066_abnormal_motor_capabilities/c1.41379807
60MP0002909_abnormal_adrenal_gland1.40279678
61MP0003787_abnormal_imprinting1.39371856
62MP0005084_abnormal_gallbladder_morpholo1.32526390
63MP0004043_abnormal_pH_regulation1.31027708
64MP0004885_abnormal_endolymph1.30834854
65MP0004742_abnormal_vestibular_system1.28735320
66MP0008875_abnormal_xenobiotic_pharmacok1.27969772
67MP0002152_abnormal_brain_morphology1.26250190
68MP0002822_catalepsy1.21814532
69MP0004142_abnormal_muscle_tone1.17961608
70MP0002234_abnormal_pharynx_morphology1.10185464
71MP0005551_abnormal_eye_electrophysiolog1.08456784
72MP0005195_abnormal_posterior_eye1.08243116
73MP0005389_reproductive_system_phenotype1.06528856
74MP0002138_abnormal_hepatobiliary_system1.05758354
75MP0003633_abnormal_nervous_system1.05442824
76MP0002928_abnormal_bile_duct1.03886102
77MP0002095_abnormal_skin_pigmentation1.03127169
78MP0000647_abnormal_sebaceous_gland1.01274032
79MP0002653_abnormal_ependyma_morphology0.99199434
80MP0002229_neurodegeneration0.98531572
81MP0002160_abnormal_reproductive_system0.97710665
82MP0001919_abnormal_reproductive_system0.96954445
83MP0008995_early_reproductive_senescence0.96377608
84MP0000631_abnormal_neuroendocrine_gland0.96167221
85MP0000026_abnormal_inner_ear0.96040776
86MP0003119_abnormal_digestive_system0.95468641
87MP0004233_abnormal_muscle_weight0.94433374
88MP0005394_taste/olfaction_phenotype0.94175600
89MP0005499_abnormal_olfactory_system0.94175600
90MP0002069_abnormal_eating/drinking_beha0.93099682
91MP0001177_atelectasis0.93051743
92MP0003631_nervous_system_phenotype0.92985178
93MP0001905_abnormal_dopamine_level0.92797956
94MP0005379_endocrine/exocrine_gland_phen0.92436953
95MP0008961_abnormal_basal_metabolism0.92322215
96MP0003634_abnormal_glial_cell0.91939571
97MP0004085_abnormal_heartbeat0.91915127
98MP0003878_abnormal_ear_physiology0.91798240
99MP0005377_hearing/vestibular/ear_phenot0.91798240
100MP0002752_abnormal_somatic_nervous0.91282392
101MP0001299_abnormal_eye_distance/0.90267095
102MP0002751_abnormal_autonomic_nervous0.86865968
103MP0003861_abnormal_nervous_system0.86492073
104MP0001324_abnormal_eye_pigmentation0.86102039
105MP0000516_abnormal_urinary_system0.85738067
106MP0005367_renal/urinary_system_phenotyp0.85738067
107MP0000383_abnormal_hair_follicle0.85624512
108MP0001188_hyperpigmentation0.84723970
109MP0003121_genomic_imprinting0.81637011
110MP0005075_abnormal_melanosome_morpholog0.80640055
111MP0000751_myopathy0.80514382
112MP0003718_maternal_effect0.79795962
113MP0000049_abnormal_middle_ear0.79685287
114MP0005410_abnormal_fertilization0.79215432
115MP0005167_abnormal_blood-brain_barrier0.78935620
116MP0003698_abnormal_male_reproductive0.78457227
117MP0002163_abnormal_gland_morphology0.78389916
118MP0001963_abnormal_hearing_physiology0.77497372
119MP0000604_amyloidosis0.74383076
120MP0003137_abnormal_impulse_conducting0.71027334
121MP0001348_abnormal_lacrimal_gland0.70215314
122MP0004145_abnormal_muscle_electrophysio0.69449716
123MP0003632_abnormal_nervous_system0.67336694
124MP0006072_abnormal_retinal_apoptosis0.67226057
125MP0000538_abnormal_urinary_bladder0.66934448
126MP0003183_abnormal_peptide_metabolism0.65542889
127MP0001664_abnormal_digestion0.65203012
128MP0008872_abnormal_physiological_respon0.64908679
129MP0005187_abnormal_penis_morphology0.62460404
130MP0000534_abnormal_ureter_morphology0.61672224
131MP0002102_abnormal_ear_morphology0.61361068
132MP0004130_abnormal_muscle_cell0.60916456
133MP0003172_abnormal_lysosome_physiology0.60406208
134MP0005253_abnormal_eye_physiology0.58540371
135MP0003283_abnormal_digestive_organ0.58460366
136MP0010769_abnormal_survival0.58401872
137MP0001943_abnormal_respiration0.58384468
138MP0010770_preweaning_lethality0.58284545
139MP0002082_postnatal_lethality0.58284545
140MP0002837_dystrophic_cardiac_calcinosis0.56222068
141MP0001986_abnormal_taste_sensitivity0.54971436
142MP0010768_mortality/aging0.54909098
143MP0002090_abnormal_vision0.54823390

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.88240034
2Myokymia (HP:0002411)6.50570873
3Focal seizures (HP:0007359)5.17429167
4Epileptic encephalopathy (HP:0200134)4.74598683
5Pancreatic cysts (HP:0001737)4.63526777
6Febrile seizures (HP:0002373)4.43809817
7Abnormality of midbrain morphology (HP:0002418)4.28819046
8Molar tooth sign on MRI (HP:0002419)4.28819046
9True hermaphroditism (HP:0010459)4.17577548
10Pancreatic fibrosis (HP:0100732)4.13314603
11Visual hallucinations (HP:0002367)4.11815356
12Atonic seizures (HP:0010819)4.06169330
13Hyperventilation (HP:0002883)3.91062689
14Polyphagia (HP:0002591)3.85169333
15Progressive cerebellar ataxia (HP:0002073)3.80227795
16Absence seizures (HP:0002121)3.78519238
17Nephronophthisis (HP:0000090)3.76527156
18Generalized tonic-clonic seizures (HP:0002069)3.73211165
19Type II lissencephaly (HP:0007260)3.65180408
20Failure to thrive in infancy (HP:0001531)3.59318588
21Congenital stationary night blindness (HP:0007642)3.58725134
22Drooling (HP:0002307)3.49222881
23Excessive salivation (HP:0003781)3.49222881
24Mutism (HP:0002300)3.46905737
25Broad-based gait (HP:0002136)3.45487628
26Pheochromocytoma (HP:0002666)3.40518070
27Ankle clonus (HP:0011448)3.40496931
28Supranuclear gaze palsy (HP:0000605)3.36170949
29Action tremor (HP:0002345)3.34089936
30Abnormal social behavior (HP:0012433)3.33820112
31Impaired social interactions (HP:0000735)3.33820112
32Dialeptic seizures (HP:0011146)3.30608587
33Poor eye contact (HP:0000817)3.25292583
34Abnormality of the renal medulla (HP:0100957)3.24541013
35Abnormal eating behavior (HP:0100738)3.19649630
36Chronic hepatic failure (HP:0100626)3.19319333
37Limb dystonia (HP:0002451)3.07591468
38Epileptiform EEG discharges (HP:0011182)3.05099011
39Cystic liver disease (HP:0006706)3.05046128
40Medial flaring of the eyebrow (HP:0010747)3.00631272
41Abnormality of the renal cortex (HP:0011035)3.00291064
42EEG with generalized epileptiform discharges (HP:0011198)2.98341103
43Abnormality of the corticospinal tract (HP:0002492)2.96198013
44Abnormality of the lower motor neuron (HP:0002366)2.92220566
45Hypoplasia of the brainstem (HP:0002365)2.87214245
46Aplasia/Hypoplasia of the brainstem (HP:0007362)2.87214245
47Sleep apnea (HP:0010535)2.85962450
48Neuroendocrine neoplasm (HP:0100634)2.84590171
49Depression (HP:0000716)2.83253661
50Abolished electroretinogram (ERG) (HP:0000550)2.76230449
51Hypsarrhythmia (HP:0002521)2.75500355
52Tubular atrophy (HP:0000092)2.73545153
53Amblyopia (HP:0000646)2.73448819
54Torticollis (HP:0000473)2.70738402
55Dysdiadochokinesis (HP:0002075)2.70641398
56Akinesia (HP:0002304)2.68958464
57Attenuation of retinal blood vessels (HP:0007843)2.67446182
58Truncal ataxia (HP:0002078)2.67395353
59Pendular nystagmus (HP:0012043)2.64914176
60Impaired vibration sensation in the lower limbs (HP:0002166)2.62201443
61Fetal akinesia sequence (HP:0001989)2.61016620
62Aqueductal stenosis (HP:0002410)2.60405416
63Lissencephaly (HP:0001339)2.59887469
64Amyotrophic lateral sclerosis (HP:0007354)2.59732278
65Termporal pattern (HP:0011008)2.59429510
66Insidious onset (HP:0003587)2.59429510
67Retinal dysplasia (HP:0007973)2.54625697
68Hemiparesis (HP:0001269)2.54616559
69Sclerocornea (HP:0000647)2.49580241
70Anxiety (HP:0000739)2.49220475
71Bile duct proliferation (HP:0001408)2.49128166
72Abnormal biliary tract physiology (HP:0012439)2.49128166
73Progressive inability to walk (HP:0002505)2.48082773
74Urinary bladder sphincter dysfunction (HP:0002839)2.46945355
75Urinary urgency (HP:0000012)2.46854739
76Absent speech (HP:0001344)2.45717050
77Papilledema (HP:0001085)2.45561665
78Spastic gait (HP:0002064)2.41236784
79Agitation (HP:0000713)2.40446045
80Cerebellar dysplasia (HP:0007033)2.40424014
81Abnormality of alanine metabolism (HP:0010916)2.37852353
82Hyperalaninemia (HP:0003348)2.37852353
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37852353
84Large for gestational age (HP:0001520)2.36210683
85Focal dystonia (HP:0004373)2.35386934
86Abnormality of the labia minora (HP:0012880)2.35197029
87Congenital primary aphakia (HP:0007707)2.33185287
883-Methylglutaconic aciduria (HP:0003535)2.31387184
89Genetic anticipation (HP:0003743)2.29978944
90Neoplasm of the peripheral nervous system (HP:0100007)2.29158930
91Furrowed tongue (HP:0000221)2.27865720
92Dysmetria (HP:0001310)2.24893350
93Nephrogenic diabetes insipidus (HP:0009806)2.24449946
94Abnormal drinking behavior (HP:0030082)2.23144106
95Polydipsia (HP:0001959)2.23144106
96Abnormality of binocular vision (HP:0011514)2.22716618
97Diplopia (HP:0000651)2.22716618
98Abnormality of salivation (HP:0100755)2.22028307
99Craniofacial dystonia (HP:0012179)2.21944159
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.21885448
101Stereotypic behavior (HP:0000733)2.21702902
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21437088
103Obstructive sleep apnea (HP:0002870)2.20968758
104Inappropriate behavior (HP:0000719)2.20903617
105Methylmalonic acidemia (HP:0002912)2.20072024
106Anencephaly (HP:0002323)2.19693422
107Inability to walk (HP:0002540)2.19590225
108Neurofibrillary tangles (HP:0002185)2.19279492
109Lower limb muscle weakness (HP:0007340)2.17202330
110Hyperthyroidism (HP:0000836)2.16765959
111Gaze-evoked nystagmus (HP:0000640)2.15565385
112Increased corneal curvature (HP:0100692)2.14790142
113Keratoconus (HP:0000563)2.14790142
114Decreased central vision (HP:0007663)2.14366192
115Hypothermia (HP:0002045)2.12721420
116Congenital, generalized hypertrichosis (HP:0004540)2.12556989
117Pachygyria (HP:0001302)2.11987172
118Cerebral inclusion bodies (HP:0100314)2.11779408
119Esotropia (HP:0000565)2.11240065
120Cortical dysplasia (HP:0002539)2.10853564
121Open mouth (HP:0000194)2.10635677
122Optic nerve hypoplasia (HP:0000609)2.09576963
123Congenital hepatic fibrosis (HP:0002612)2.09210490
124Intestinal atresia (HP:0011100)2.07235441
125Male pseudohermaphroditism (HP:0000037)2.06346999
126Protruding tongue (HP:0010808)2.06233801
127Specific learning disability (HP:0001328)2.05962342
128Acute necrotizing encephalopathy (HP:0006965)2.05393170
129Oligodactyly (hands) (HP:0001180)2.05124764
130Postaxial foot polydactyly (HP:0001830)2.04553754
131Abnormality of the pons (HP:0007361)2.04346365
132Postural instability (HP:0002172)2.03867993
133Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03187066
134Severe muscular hypotonia (HP:0006829)2.02647672
135Hypoventilation (HP:0002791)2.01436224
136Genital tract atresia (HP:0001827)2.01381218
137Abnormal rod and cone electroretinograms (HP:0008323)2.00396261
138Bradykinesia (HP:0002067)1.98243634
139Patellar aplasia (HP:0006443)1.96249330
140Vaginal atresia (HP:0000148)1.96117331
141Hypoplasia of the pons (HP:0012110)1.95920678
142Exotropia (HP:0000577)1.95399297
143Increased CSF lactate (HP:0002490)1.94983943
144Scanning speech (HP:0002168)1.94703180
145Chorioretinal atrophy (HP:0000533)1.94460714
146Polyuria (HP:0000103)1.93995672
147Progressive macrocephaly (HP:0004481)1.93674646
148Mitochondrial inheritance (HP:0001427)1.93307926
149Hypoplasia of the fovea (HP:0007750)1.93138908
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.93138908
151Sporadic (HP:0003745)1.92928240
152Concave nail (HP:0001598)1.92618493
153Postaxial hand polydactyly (HP:0001162)1.90956946
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.90139105
155Hypoplasia of the corpus callosum (HP:0002079)1.90079612
156Decreased circulating renin level (HP:0003351)1.89735152
157Aplasia/Hypoplasia of the patella (HP:0006498)1.89580806
158Partial agenesis of the corpus callosum (HP:0001338)1.89079625
159Abnormal hair whorl (HP:0010721)1.86594819
160Occipital encephalocele (HP:0002085)1.86455407
161Megalencephaly (HP:0001355)1.86054999
162Status epilepticus (HP:0002133)1.85622413
163Renal cortical cysts (HP:0000803)1.84634725
164Clonus (HP:0002169)1.83672806
165Morphological abnormality of the pyramidal tract (HP:0002062)1.82121819
166Acute encephalopathy (HP:0006846)1.81967885
167Blue irides (HP:0000635)1.81291692
168Incomplete penetrance (HP:0003829)1.81137416
169Gait imbalance (HP:0002141)1.80432997
170Poor suck (HP:0002033)1.79937921
171Absent/shortened dynein arms (HP:0200106)1.79033590
172Dynein arm defect of respiratory motile cilia (HP:0012255)1.79033590
173Optic disc pallor (HP:0000543)1.79013324
174Dandy-Walker malformation (HP:0001305)1.78592717
175Methylmalonic aciduria (HP:0012120)1.78569729
176Anophthalmia (HP:0000528)1.78479185
177Birth length less than 3rd percentile (HP:0003561)1.75865258
178Bilateral microphthalmos (HP:0007633)1.74838752
179Abnormal respiratory epithelium morphology (HP:0012253)1.74781545
180Abnormal respiratory motile cilium morphology (HP:0005938)1.74781545
181Fair hair (HP:0002286)1.73541549
182Pointed chin (HP:0000307)1.71782302
183Cortical visual impairment (HP:0100704)1.70582376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.61143957
2FRK5.26299695
3NTRK33.45105651
4EPHA43.17175667
5MINK13.02446063
6SIK32.97180760
7ADRBK22.92387040
8MAP3K42.86025837
9MAP3K92.77428308
10ZAK2.68418312
11CASK2.55128701
12MAP4K22.54465042
13MAP2K72.44724563
14GRK12.43196150
15PINK12.40483521
16KSR12.33470503
17PAK62.27976132
18TLK12.13800764
19DAPK22.13086009
20MAP3K122.12133378
21TRIM282.11779005
22SIK22.11208329
23NTRK22.11044757
24WNK42.01164659
25INSRR2.00754622
26MAP2K41.99534781
27TAOK31.85854020
28NUAK11.68619373
29KSR21.68539945
30PRPF4B1.67311156
31MAPK131.63004732
32PHKG11.62023712
33PHKG21.62023712
34TXK1.55656766
35CDK51.54425309
36BCR1.45203803
37DYRK21.41789518
38ERBB31.39793238
39NTRK11.38511541
40DAPK11.32885133
41MKNK21.29427846
42UHMK11.26504091
43CAMKK11.25345542
44PNCK1.20432699
45LATS21.19062676
46PLK21.17491974
47PAK31.14197481
48PRKCG1.14063201
49SGK4941.11242051
50SGK2231.11242051
51CDK191.07013090
52MARK21.06247871
53SGK21.04101044
54TNIK1.03482474
55CDK181.02407869
56CSNK1G11.01790203
57PRKD30.97369565
58FGFR20.96278855
59BCKDK0.96241068
60STK38L0.94340547
61TGFBR10.93652826
62CDK140.92536775
63STK390.92319964
64RIPK40.91988299
65CAMK2A0.91385621
66CDK150.89813920
67GRK50.89758176
68BMPR1B0.89699164
69PIK3CA0.89586274
70LIMK10.88779445
71CSNK1G20.87059478
72VRK10.85339046
73CCNB10.84156850
74RET0.82760663
75CAMK2B0.77874407
76MAP3K20.77773458
77SGK30.76037002
78CDK11A0.74495130
79MST40.74041525
80TIE10.73332487
81WNK30.72538177
82RPS6KA20.71999335
83ICK0.70867031
84PRKCH0.69854865
85DYRK1A0.69795825
86MKNK10.69550706
87LMTK20.68365687
88BRSK20.66688090
89PLK30.65447607
90CAMKK20.64512913
91PRKCZ0.64266637
92MAP2K10.64074677
93PTK2B0.63862630
94SGK10.63850470
95FES0.63595040
96MAPK150.62308440
97PRKCE0.58089712
98CAMK10.57577587
99EIF2AK30.56476053
100IRAK20.56326119
101EPHA30.54295167
102TAOK10.53629243
103CAMK1G0.53198063
104OXSR10.52664793
105CSNK1A10.52022225
106ALK0.51912387
107RPS6KA50.51187230
108STK110.51012525
109MAP3K10.49035667
110PLK40.48603026
111PKN10.47201762
112PRKACA0.45679241
113MUSK0.45579209
114FYN0.45215025
115RAF10.44906773
116MAPKAPK30.44820042
117PRKCQ0.44732336
118GRK70.44262825
119ACVR1B0.43883471
120RPS6KA30.42671694
121CAMK2D0.41944702
122FER0.41688105
123CSNK1D0.41095861
124TYRO30.40803087
125FLT30.39993384
126OBSCN0.39853617
127AKT30.39619925
128STK380.39595317
129NME10.39201003
130CSNK1G30.38453520
131ERBB20.38431269
132CSNK1A1L0.37733621
133MAPK120.36100583
134MAPK80.35490914
135MAPKAPK50.35294285
136EPHB20.35158101
137PRKCA0.33727328
138PRKG10.33576544
139MAPK100.32589956
140ADRBK10.32329708
141NEK10.31364676
142DYRK30.30594826
143SRPK10.30541273
144MAPK90.30287314
145MAP2K60.28874304
146PRKCB0.28712725
147CAMK2G0.28487832
148PLK10.28447052
149CDC42BPA0.28420887
150NLK0.27487831
151PRKAA10.27444021

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79850672
2Synaptic vesicle cycle_Homo sapiens_hsa047213.50879721
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54754977
4Circadian entrainment_Homo sapiens_hsa047132.54066537
5GABAergic synapse_Homo sapiens_hsa047272.51625918
6Olfactory transduction_Homo sapiens_hsa047402.51457617
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42201086
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38625763
9Glutamatergic synapse_Homo sapiens_hsa047242.35019234
10Long-term potentiation_Homo sapiens_hsa047202.34198597
11Nitrogen metabolism_Homo sapiens_hsa009102.32482861
12Protein export_Homo sapiens_hsa030602.30962230
13Morphine addiction_Homo sapiens_hsa050322.30600532
14Dopaminergic synapse_Homo sapiens_hsa047282.29650881
15Linoleic acid metabolism_Homo sapiens_hsa005912.25730670
16Amphetamine addiction_Homo sapiens_hsa050312.17839527
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16854343
18Oxidative phosphorylation_Homo sapiens_hsa001902.16108278
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.14884715
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10733342
21Cholinergic synapse_Homo sapiens_hsa047252.08995326
22Insulin secretion_Homo sapiens_hsa049111.97972771
23Selenocompound metabolism_Homo sapiens_hsa004501.94809604
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.90758916
25Axon guidance_Homo sapiens_hsa043601.86669704
26Serotonergic synapse_Homo sapiens_hsa047261.84894824
27Salivary secretion_Homo sapiens_hsa049701.82085797
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78066330
29Ether lipid metabolism_Homo sapiens_hsa005651.73953409
30Collecting duct acid secretion_Homo sapiens_hsa049661.72377562
31Homologous recombination_Homo sapiens_hsa034401.71884599
32Tryptophan metabolism_Homo sapiens_hsa003801.69521797
33Renin secretion_Homo sapiens_hsa049241.69259565
34Long-term depression_Homo sapiens_hsa047301.68901106
35Parkinsons disease_Homo sapiens_hsa050121.68444201
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65765887
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65506678
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63930891
39Taste transduction_Homo sapiens_hsa047421.61836070
40RNA polymerase_Homo sapiens_hsa030201.60506331
41Propanoate metabolism_Homo sapiens_hsa006401.57492472
42Gap junction_Homo sapiens_hsa045401.54189481
43Cocaine addiction_Homo sapiens_hsa050301.52521980
44Gastric acid secretion_Homo sapiens_hsa049711.50717329
45Basal transcription factors_Homo sapiens_hsa030221.50040133
46Oxytocin signaling pathway_Homo sapiens_hsa049211.46776963
47Fanconi anemia pathway_Homo sapiens_hsa034601.44937260
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44519754
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.42823947
50GnRH signaling pathway_Homo sapiens_hsa049121.33363909
51Calcium signaling pathway_Homo sapiens_hsa040201.33164857
52Caffeine metabolism_Homo sapiens_hsa002321.29842673
53Vibrio cholerae infection_Homo sapiens_hsa051101.29754066
54RNA degradation_Homo sapiens_hsa030181.25449465
55Type II diabetes mellitus_Homo sapiens_hsa049301.25107867
56ErbB signaling pathway_Homo sapiens_hsa040121.24677791
57Peroxisome_Homo sapiens_hsa041461.23706464
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19857505
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12629101
60Estrogen signaling pathway_Homo sapiens_hsa049151.12615729
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11510091
62cAMP signaling pathway_Homo sapiens_hsa040241.11302869
63Glioma_Homo sapiens_hsa052141.10941583
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10514434
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09033095
66Huntingtons disease_Homo sapiens_hsa050161.08493270
67Chemical carcinogenesis_Homo sapiens_hsa052041.04853519
68ABC transporters_Homo sapiens_hsa020100.98829399
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98015204
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.95328173
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94931654
72Phototransduction_Homo sapiens_hsa047440.94689803
73Cardiac muscle contraction_Homo sapiens_hsa042600.92375040
74Melanogenesis_Homo sapiens_hsa049160.92297260
75Regulation of autophagy_Homo sapiens_hsa041400.90966315
76One carbon pool by folate_Homo sapiens_hsa006700.89985536
77Arachidonic acid metabolism_Homo sapiens_hsa005900.89875258
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89816491
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.87087916
80Oocyte meiosis_Homo sapiens_hsa041140.82042825
81Retinol metabolism_Homo sapiens_hsa008300.81817925
82Endometrial cancer_Homo sapiens_hsa052130.80300547
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79275516
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.76890682
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76323097
86Steroid biosynthesis_Homo sapiens_hsa001000.76155767
87Colorectal cancer_Homo sapiens_hsa052100.75818059
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.75522374
89MAPK signaling pathway_Homo sapiens_hsa040100.74923018
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74654193
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73354526
92Ovarian steroidogenesis_Homo sapiens_hsa049130.72187070
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72020915
94Choline metabolism in cancer_Homo sapiens_hsa052310.70951939
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70270196
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68960785
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68487391
98Fat digestion and absorption_Homo sapiens_hsa049750.67165565
99beta-Alanine metabolism_Homo sapiens_hsa004100.67123045
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.66417378
101Purine metabolism_Homo sapiens_hsa002300.66283230
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66236732
103Renal cell carcinoma_Homo sapiens_hsa052110.65673878
104Dilated cardiomyopathy_Homo sapiens_hsa054140.65128494
105VEGF signaling pathway_Homo sapiens_hsa043700.64179887
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64156721
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.63368624
108Ras signaling pathway_Homo sapiens_hsa040140.63236246
109Proteasome_Homo sapiens_hsa030500.62070346
110Thyroid hormone synthesis_Homo sapiens_hsa049180.60658675
111Asthma_Homo sapiens_hsa053100.60201115
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59351617
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58971546
114Glycerolipid metabolism_Homo sapiens_hsa005610.58365737
115Metabolic pathways_Homo sapiens_hsa011000.57833207
116Alcoholism_Homo sapiens_hsa050340.57733968
117Pancreatic secretion_Homo sapiens_hsa049720.56743972
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56291356
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55982230
120Sulfur metabolism_Homo sapiens_hsa009200.54641602
121Endocytosis_Homo sapiens_hsa041440.54317981
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54207476
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53269708
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53260499
125Glucagon signaling pathway_Homo sapiens_hsa049220.52681997
126Non-homologous end-joining_Homo sapiens_hsa034500.51791272
127Histidine metabolism_Homo sapiens_hsa003400.49257935
128Hedgehog signaling pathway_Homo sapiens_hsa043400.48887349
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48521520
130Phagosome_Homo sapiens_hsa041450.48381890
131Insulin signaling pathway_Homo sapiens_hsa049100.48328948
132Dorso-ventral axis formation_Homo sapiens_hsa043200.48196019
133Vitamin digestion and absorption_Homo sapiens_hsa049770.46108043
134Rap1 signaling pathway_Homo sapiens_hsa040150.46022761
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44834113
136mTOR signaling pathway_Homo sapiens_hsa041500.43975013
137Wnt signaling pathway_Homo sapiens_hsa043100.43281686
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43185086
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.42533190
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42021481
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41908056
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41054181
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40965401
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40670112
145Prion diseases_Homo sapiens_hsa050200.40231125
146Alzheimers disease_Homo sapiens_hsa050100.37729880
147Sulfur relay system_Homo sapiens_hsa041220.35981082
148Primary immunodeficiency_Homo sapiens_hsa053400.35791309
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35554846
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35516070
151Rheumatoid arthritis_Homo sapiens_hsa053230.35193921
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.34973609
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34930644
154Non-small cell lung cancer_Homo sapiens_hsa052230.34275700
155Mineral absorption_Homo sapiens_hsa049780.33421956
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.32847506
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32120349
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32019571
159Butanoate metabolism_Homo sapiens_hsa006500.31300429
160Bile secretion_Homo sapiens_hsa049760.30942199
161Circadian rhythm_Homo sapiens_hsa047100.30721965
162Type I diabetes mellitus_Homo sapiens_hsa049400.30354166
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29714944
164Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27384830

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