PCDHAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)6.56947195
2negative regulation of dendrite morphogenesis (GO:0050774)5.75989797
3neuronal action potential propagation (GO:0019227)5.17161756
4cell migration in hindbrain (GO:0021535)5.11934719
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.02932344
6innervation (GO:0060384)4.96187287
7synaptic vesicle exocytosis (GO:0016079)4.86461039
8synaptic vesicle maturation (GO:0016188)4.85921226
9negative regulation of dendrite development (GO:2000171)4.74494602
10vocalization behavior (GO:0071625)4.67251682
11cell wall macromolecule catabolic process (GO:0016998)4.60379645
12regulation of synaptic vesicle exocytosis (GO:2000300)4.60310531
13calcium-mediated signaling using intracellular calcium source (GO:0035584)4.53349308
14neuron cell-cell adhesion (GO:0007158)4.42950755
15glutamate secretion (GO:0014047)4.41954405
16exploration behavior (GO:0035640)4.34459878
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33936661
18detection of temperature stimulus (GO:0016048)4.15459488
19membrane depolarization during action potential (GO:0086010)4.14337286
20positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.12347155
21serotonin metabolic process (GO:0042428)4.07272479
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.06447602
23regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.05191894
24protein localization to synapse (GO:0035418)4.02689227
25regulation of synaptic vesicle transport (GO:1902803)4.01665298
26detection of temperature stimulus involved in sensory perception (GO:0050961)3.95512331
27detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.95512331
28proline transport (GO:0015824)3.94870711
29regulation of NFAT protein import into nucleus (GO:0051532)3.93170739
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.91836619
31auditory behavior (GO:0031223)3.90905862
32cell wall macromolecule metabolic process (GO:0044036)3.90693137
33postsynaptic membrane organization (GO:0001941)3.89052423
34regulation of cell communication by electrical coupling (GO:0010649)3.81478005
35locomotory exploration behavior (GO:0035641)3.80526416
36regulation of neuronal synaptic plasticity (GO:0048168)3.76517515
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69283851
38nucleobase catabolic process (GO:0046113)3.69090051
39microtubule severing (GO:0051013)3.68364755
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.62730576
41neuromuscular process controlling posture (GO:0050884)3.61495867
42neurotransmitter secretion (GO:0007269)3.59397467
43presynaptic membrane assembly (GO:0097105)3.57575617
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.55728450
45regulation of glutamate receptor signaling pathway (GO:1900449)3.49388448
46primary amino compound metabolic process (GO:1901160)3.48015787
47peripheral nervous system neuron development (GO:0048935)3.47685679
48regulation of protein heterodimerization activity (GO:0043497)3.46374150
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46284036
50negative regulation of microtubule polymerization (GO:0031115)3.45019490
51regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.40622309
52cerebellar Purkinje cell differentiation (GO:0021702)3.40380869
53positive regulation of potassium ion transmembrane transport (GO:1901381)3.40160837
54regulation of sodium ion transmembrane transporter activity (GO:2000649)3.37871909
55synaptic vesicle endocytosis (GO:0048488)3.37295796
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33596991
57establishment of mitochondrion localization (GO:0051654)3.31184345
58neurotransmitter-gated ion channel clustering (GO:0072578)3.27403576
59mechanosensory behavior (GO:0007638)3.27220292
60mitochondrion transport along microtubule (GO:0047497)3.26585427
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.26585427
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26054956
63neuron recognition (GO:0008038)3.24812303
64negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.20179067
65activation of protein kinase A activity (GO:0034199)3.18899319
66glutamate receptor signaling pathway (GO:0007215)3.18719509
67inositol phosphate catabolic process (GO:0071545)3.17559438
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.17453178
69neuronal action potential (GO:0019228)3.17380981
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16657896
71layer formation in cerebral cortex (GO:0021819)3.16046145
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15241920
73cellular potassium ion homeostasis (GO:0030007)3.14385651
74organelle transport along microtubule (GO:0072384)3.14261009
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13768010
76positive regulation of muscle hypertrophy (GO:0014742)3.12683766
77positive regulation of cardiac muscle hypertrophy (GO:0010613)3.12683766
78synapse assembly (GO:0007416)3.11895608
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11245431
80regulation of synapse structural plasticity (GO:0051823)3.10085808
81cochlea development (GO:0090102)3.05997895
82regulation of gene silencing by RNA (GO:0060966)3.05628675
83regulation of posttranscriptional gene silencing (GO:0060147)3.05628675
84regulation of gene silencing by miRNA (GO:0060964)3.05628675
85neuromuscular process controlling balance (GO:0050885)3.05539036
86regulation of calcium ion transmembrane transport (GO:1903169)3.04896739
87regulation of calcium ion transmembrane transporter activity (GO:1901019)3.04896739
88synaptic transmission, glutamatergic (GO:0035249)3.02066263
89cell communication by electrical coupling (GO:0010644)3.01926200
90presynaptic membrane organization (GO:0097090)3.01284219
91brain morphogenesis (GO:0048854)3.00015326
92neurotransmitter transport (GO:0006836)2.98179767
93vesicle transport along microtubule (GO:0047496)2.97756666
94ionotropic glutamate receptor signaling pathway (GO:0035235)2.97330231
95cell communication involved in cardiac conduction (GO:0086065)2.96686673
96dendrite morphogenesis (GO:0048813)2.96529713
97activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.96089264
98neuron-neuron synaptic transmission (GO:0007270)2.95374194
99membrane depolarization (GO:0051899)2.93717236
100resolution of meiotic recombination intermediates (GO:0000712)2.92430236
101negative regulation of sodium ion transport (GO:0010766)2.91064955
102ribonucleoprotein complex disassembly (GO:0032988)2.90399678
103central nervous system projection neuron axonogenesis (GO:0021952)2.89693183
104axon cargo transport (GO:0008088)2.89359792
105regulation of heart rate by cardiac conduction (GO:0086091)2.89243964
106acrosome reaction (GO:0007340)2.88839558
107regulation of vesicle fusion (GO:0031338)2.88120182
108regulation of synaptic plasticity (GO:0048167)2.87676631
109neuromuscular process (GO:0050905)2.86749625
110single strand break repair (GO:0000012)2.86091947
111membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84862997
112striatum development (GO:0021756)2.84473754
113regulation of membrane repolarization (GO:0060306)2.84327957
114axonal fasciculation (GO:0007413)2.83505025
115negative regulation of cation channel activity (GO:2001258)2.81837687
116positive regulation of potassium ion transport (GO:0043268)2.81827947
117phosphorelay signal transduction system (GO:0000160)2.81234976
118transmission of nerve impulse (GO:0019226)2.81127645
119positive regulation of synapse maturation (GO:0090129)2.79857382
120response to auditory stimulus (GO:0010996)2.78334914
121startle response (GO:0001964)2.78038712
122atrial cardiac muscle cell action potential (GO:0086014)2.77419689
123gamma-aminobutyric acid transport (GO:0015812)2.77191305
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.76781968
125pyrimidine nucleobase catabolic process (GO:0006208)2.76374879
126sympathetic nervous system development (GO:0048485)2.74764492
127cerebellar granule cell differentiation (GO:0021707)2.74035194
128social behavior (GO:0035176)2.73613633
129intraspecies interaction between organisms (GO:0051703)2.73613633
130positive regulation of vesicle fusion (GO:0031340)2.70647510
131acrosome assembly (GO:0001675)2.63356721
132positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.63192825
133behavioral response to nicotine (GO:0035095)2.58459984
134regulation of centriole replication (GO:0046599)2.56043103
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.55659103
136retina layer formation (GO:0010842)2.51170564
137* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.50969960
138protein polyglutamylation (GO:0018095)2.50508404
139regulation of telomere maintenance (GO:0032204)2.49841624
140neurotransmitter uptake (GO:0001504)2.47828602
141axon extension (GO:0048675)2.47172703
142bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45943635
143thalamus development (GO:0021794)2.45155875
144calcium ion-dependent exocytosis (GO:0017156)2.44734830
145coenzyme A biosynthetic process (GO:0015937)2.44428321
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44000790
147dendrite development (GO:0016358)2.43872287
148calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43713097
149positive regulation of synapse assembly (GO:0051965)2.35828029
150central nervous system neuron axonogenesis (GO:0021955)2.35323337
151nerve growth factor signaling pathway (GO:0038180)2.34650635
152regulation of neurotransmitter levels (GO:0001505)2.34200337
153hindbrain development (GO:0030902)2.33356231
154microtubule nucleation (GO:0007020)2.33264070
155regulation of synapse assembly (GO:0051963)2.32034004
156cranial nerve morphogenesis (GO:0021602)2.29795042
157neuron maturation (GO:0042551)2.29032693
158behavioral fear response (GO:0001662)2.28354786
159behavioral defense response (GO:0002209)2.28354786
160dendritic spine morphogenesis (GO:0060997)2.27433900
161behavioral response to ethanol (GO:0048149)2.27015243
162regulation of neuron migration (GO:2001222)2.25936089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28899566
2GBX2_23144817_ChIP-Seq_PC3_Human4.14917168
3IGF1R_20145208_ChIP-Seq_DFB_Human3.18756864
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15573270
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15449725
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97240991
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88205835
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75340387
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75340387
10TAF15_26573619_Chip-Seq_HEK293_Human2.61078686
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56932390
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54039028
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.52814706
14FUS_26573619_Chip-Seq_HEK293_Human2.50290265
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46902300
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44159466
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42834834
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40463779
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.30043748
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24802745
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.21251854
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.14377514
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.10520617
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06573584
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.06164650
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98281515
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.97757893
28SMAD4_21799915_ChIP-Seq_A2780_Human1.97733684
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96839686
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.96839686
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.94326719
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91140122
33AR_21572438_ChIP-Seq_LNCaP_Human1.89258761
34* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89214138
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87417917
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80072448
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79087690
38DROSHA_22980978_ChIP-Seq_HELA_Human1.77639537
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77345637
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75417210
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71352295
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.67783566
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66347141
44ZNF274_21170338_ChIP-Seq_K562_Hela1.66250004
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65002073
46P300_19829295_ChIP-Seq_ESCs_Human1.64743040
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59227477
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56020449
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54070917
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52017208
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50652845
52EWS_26573619_Chip-Seq_HEK293_Human1.48207303
53AR_25329375_ChIP-Seq_VCAP_Human1.46611126
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46392923
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.44934888
56RNF2_27304074_Chip-Seq_NSC_Mouse1.44677428
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.40903782
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.39317817
59CBP_20019798_ChIP-Seq_JUKART_Human1.39116988
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39116988
61AHR_22903824_ChIP-Seq_MCF-7_Human1.38001183
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37340414
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36845803
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36423392
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36420522
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35785348
67STAT3_23295773_ChIP-Seq_U87_Human1.35354338
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34876127
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.33737477
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31520718
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30989425
72SOX9_26525672_Chip-Seq_HEART_Mouse1.30097557
73AR_19668381_ChIP-Seq_PC3_Human1.26951613
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.26864229
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.26308517
76ER_23166858_ChIP-Seq_MCF-7_Human1.25031636
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.23409727
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.21541273
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21141614
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19193716
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16319978
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.15967894
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14909040
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13474507
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12446541
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12430983
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.11650263
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.11536917
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11390990
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10653087
91BCAT_22108803_ChIP-Seq_LS180_Human1.09741916
92TCF4_23295773_ChIP-Seq_U87_Human1.09076479
93* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08728874
94* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08118275
95VDR_22108803_ChIP-Seq_LS180_Human1.08070015
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06708006
97RUNX2_22187159_ChIP-Seq_PCA_Human1.05332117
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05162140
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04840903
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04738534
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.03701846
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03699007
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03231716
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02979223
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02711028
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02701026
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02125580
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02104649
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01854858
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01523983
111TP53_18474530_ChIP-ChIP_U2OS_Human1.00083597
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98382689
113JUN_21703547_ChIP-Seq_K562_Human0.97996702
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.97973313
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97208018
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96046203
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.96001320
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.95672030
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95302338
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.94811668
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93666897
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.93127603
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.93000346
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92088693
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91196258
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88912878
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.83708134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia5.06442334
2MP0002735_abnormal_chemical_nociception4.82981634
3MP0004859_abnormal_synaptic_plasticity4.44828143
4MP0003880_abnormal_central_pattern3.97675030
5MP0006276_abnormal_autonomic_nervous3.89923369
6MP0001968_abnormal_touch/_nociception3.41097677
7MP0009046_muscle_twitch3.34891567
8MP0003635_abnormal_synaptic_transmissio3.29219526
9MP0002734_abnormal_mechanical_nocicepti3.25455920
10MP0002736_abnormal_nociception_after3.20245950
11MP0000569_abnormal_digit_pigmentation3.11906612
12MP0004858_abnormal_nervous_system2.93007717
13MP0002272_abnormal_nervous_system2.78943288
14MP0009745_abnormal_behavioral_response2.69403012
15MP0002733_abnormal_thermal_nociception2.68330257
16MP0002063_abnormal_learning/memory/cond2.66241628
17MP0002064_seizures2.53719912
18MP0002184_abnormal_innervation2.47218904
19MP0002572_abnormal_emotion/affect_behav2.33256052
20MP0001970_abnormal_pain_threshold2.29033167
21MP0001486_abnormal_startle_reflex2.23831868
22MP0002067_abnormal_sensory_capabilities2.19644692
23MP0002234_abnormal_pharynx_morphology2.01327884
24MP0005645_abnormal_hypothalamus_physiol1.93975161
25MP0004147_increased_porphyrin_level1.91766754
26MP0003329_amyloid_beta_deposits1.88558525
27MP0001501_abnormal_sleep_pattern1.79371614
28MP0008569_lethality_at_weaning1.78247106
29MP0002751_abnormal_autonomic_nervous1.77926354
30MP0000955_abnormal_spinal_cord1.75394551
31MP0000778_abnormal_nervous_system1.74322603
32MP0005423_abnormal_somatic_nervous1.73813749
33MP0003890_abnormal_embryonic-extraembry1.72645080
34MP0003121_genomic_imprinting1.69158367
35MP0004145_abnormal_muscle_electrophysio1.65162359
36MP0003879_abnormal_hair_cell1.61939043
37MP0001440_abnormal_grooming_behavior1.61205037
38MP0003937_abnormal_limbs/digits/tail_de1.59304198
39MP0001348_abnormal_lacrimal_gland1.58961143
40MP0004811_abnormal_neuron_physiology1.57796836
41MP0001984_abnormal_olfaction1.53288922
42MP0002557_abnormal_social/conspecific_i1.49808460
43MP0001986_abnormal_taste_sensitivity1.48734156
44MP0001188_hyperpigmentation1.47084083
45MP0004142_abnormal_muscle_tone1.44564818
46MP0003122_maternal_imprinting1.43639985
47MP0005386_behavior/neurological_phenoty1.41863632
48MP0004924_abnormal_behavior1.41863632
49MP0002638_abnormal_pupillary_reflex1.41005453
50MP0002882_abnormal_neuron_morphology1.40390922
51MP0002837_dystrophic_cardiac_calcinosis1.35670652
52MP0000579_abnormal_nail_morphology1.35027101
53MP0002066_abnormal_motor_capabilities/c1.34369538
54MP0002822_catalepsy1.33556034
55MP0002938_white_spotting1.32365817
56MP0003861_abnormal_nervous_system1.32050778
57MP0008057_abnormal_DNA_replication1.26880159
58MP0002909_abnormal_adrenal_gland1.25858043
59MP0009780_abnormal_chondrocyte_physiolo1.22215521
60MP0004133_heterotaxia1.21820824
61MP0005410_abnormal_fertilization1.21383392
62MP0004484_altered_response_of1.20895781
63MP0001529_abnormal_vocalization1.15888508
64MP0002229_neurodegeneration1.14924453
65MP0003633_abnormal_nervous_system1.14316840
66MP0002697_abnormal_eye_size1.14071247
67MP0004085_abnormal_heartbeat1.14044542
68MP0002102_abnormal_ear_morphology1.13178259
69MP0000537_abnormal_urethra_morphology1.12901624
70MP0000516_abnormal_urinary_system1.09799896
71MP0005367_renal/urinary_system_phenotyp1.09799896
72MP0005248_abnormal_Harderian_gland1.08495837
73MP0005646_abnormal_pituitary_gland1.06955587
74MP0003136_yellow_coat_color1.06192152
75MP0000372_irregular_coat_pigmentation1.05878092
76MP0000751_myopathy1.04256293
77MP0001905_abnormal_dopamine_level1.03915121
78MP0003631_nervous_system_phenotype1.03088230
79MP0001293_anophthalmia1.02696170
80MP0001963_abnormal_hearing_physiology1.02419939
81MP0000383_abnormal_hair_follicle1.02360638
82MP0005171_absent_coat_pigmentation1.00287299
83MP0003119_abnormal_digestive_system0.99248148
84MP0002752_abnormal_somatic_nervous0.98150488
85MP0001485_abnormal_pinna_reflex0.97645837
86MP0003634_abnormal_glial_cell0.96139149
87MP0003698_abnormal_male_reproductive0.95454665
88MP0000534_abnormal_ureter_morphology0.94567583
89MP0002233_abnormal_nose_morphology0.94406092
90MP0005535_abnormal_body_temperature0.93707578
91MP0000427_abnormal_hair_cycle0.93068218
92MP0000604_amyloidosis0.91757742
93MP0003787_abnormal_imprinting0.89628764
94MP0002152_abnormal_brain_morphology0.89514182
95MP0008874_decreased_physiological_sensi0.88845504
96MP0002653_abnormal_ependyma_morphology0.87159839
97MP0000920_abnormal_myelination0.86957393
98MP0008877_abnormal_DNA_methylation0.86599094
99MP0005394_taste/olfaction_phenotype0.86165218
100MP0005499_abnormal_olfactory_system0.86165218
101MP0000566_synostosis0.85034345
102MP0003183_abnormal_peptide_metabolism0.84380311
103MP0002081_perinatal_lethality0.82014071
104MP0003718_maternal_effect0.80300090
105MP0003935_abnormal_craniofacial_develop0.79383044
106MP0004742_abnormal_vestibular_system0.78785827
107MP0001177_atelectasis0.78656586
108MP0003632_abnormal_nervous_system0.76643360
109MP0003567_abnormal_fetal_cardiomyocyte0.76622120
110MP0009697_abnormal_copulation0.76556101
111MP0001324_abnormal_eye_pigmentation0.75880044
112MP0000049_abnormal_middle_ear0.74910630
113MP0008770_decreased_survivor_rate0.74570964
114MP0002082_postnatal_lethality0.74358244
115MP0010770_preweaning_lethality0.74358244
116MP0002069_abnormal_eating/drinking_beha0.73806973
117MP0003878_abnormal_ear_physiology0.73637912
118MP0005377_hearing/vestibular/ear_phenot0.73637912
119MP0005195_abnormal_posterior_eye0.72544664
120MP0001502_abnormal_circadian_rhythm0.70731700
121MP0005623_abnormal_meninges_morphology0.70641819
122MP0002876_abnormal_thyroid_physiology0.70599913
123MP0001299_abnormal_eye_distance/0.70144544
124MP0003137_abnormal_impulse_conducting0.69836016
125MP0005551_abnormal_eye_electrophysiolog0.69795648
126MP0004885_abnormal_endolymph0.68435030
127MP0008775_abnormal_heart_ventricle0.67510541
128MP0004215_abnormal_myocardial_fiber0.61767766
129MP0001943_abnormal_respiration0.61610080
130MP0009379_abnormal_foot_pigmentation0.59944413
131MP0008789_abnormal_olfactory_epithelium0.58939858
132MP0003283_abnormal_digestive_organ0.58806532
133MP0004036_abnormal_muscle_relaxation0.58071079
134MP0004134_abnormal_chest_morphology0.57327418
135MP0000026_abnormal_inner_ear0.56817690
136MP0002972_abnormal_cardiac_muscle0.56013587
137MP0001919_abnormal_reproductive_system0.55365000
138MP0000631_abnormal_neuroendocrine_gland0.51440208
139MP0004883_abnormal_blood_vessel0.51150768
140MP0005166_decreased_susceptibility_to0.50662369
141MP0002160_abnormal_reproductive_system0.50374182
142MP0000538_abnormal_urinary_bladder0.49322633

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.91949709
2Focal motor seizures (HP:0011153)6.52416398
3Action tremor (HP:0002345)6.33481292
4Febrile seizures (HP:0002373)5.48692035
5Atonic seizures (HP:0010819)5.25312971
6Ulnar claw (HP:0001178)4.84360362
7Progressive cerebellar ataxia (HP:0002073)4.82099506
8Focal seizures (HP:0007359)4.64069110
9Insidious onset (HP:0003587)4.21190635
10Termporal pattern (HP:0011008)4.21190635
11Epileptic encephalopathy (HP:0200134)4.11739273
12Scanning speech (HP:0002168)3.99314722
13Absence seizures (HP:0002121)3.84792700
14Pheochromocytoma (HP:0002666)3.70278700
15Supranuclear gaze palsy (HP:0000605)3.51174487
16Generalized tonic-clonic seizures (HP:0002069)3.40321998
17Neuroendocrine neoplasm (HP:0100634)3.35842066
18Dialeptic seizures (HP:0011146)3.33887857
19Visual hallucinations (HP:0002367)3.33744660
20Truncal ataxia (HP:0002078)3.25870652
21Urinary bladder sphincter dysfunction (HP:0002839)3.22960596
22Drooling (HP:0002307)3.21347742
23Genetic anticipation (HP:0003743)3.06830932
24Gaze-evoked nystagmus (HP:0000640)3.05441925
25Chronic hepatic failure (HP:0100626)3.04801380
26Hypothermia (HP:0002045)3.03514583
27Amblyopia (HP:0000646)2.89465009
28Abnormality of pain sensation (HP:0010832)2.88539947
29Impaired pain sensation (HP:0007328)2.88539947
30Impaired vibration sensation in the lower limbs (HP:0002166)2.87617610
31Excessive salivation (HP:0003781)2.87522190
32Ankle clonus (HP:0011448)2.84920484
33Urinary urgency (HP:0000012)2.81365615
34Hyperventilation (HP:0002883)2.80859546
35Spastic gait (HP:0002064)2.78245857
36Abnormality of the corticospinal tract (HP:0002492)2.75404123
37Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.74062666
38Failure to thrive in infancy (HP:0001531)2.70265012
39Impaired smooth pursuit (HP:0007772)2.69151137
40Delusions (HP:0000746)2.69111929
41Depression (HP:0000716)2.67125150
42Dysdiadochokinesis (HP:0002075)2.64370836
43Anxiety (HP:0000739)2.53812412
44Bifid tongue (HP:0010297)2.49977295
45Abnormal social behavior (HP:0012433)2.44905994
46Impaired social interactions (HP:0000735)2.44905994
47Colon cancer (HP:0003003)2.44575660
48Homocystinuria (HP:0002156)2.43235827
49Abnormality of homocysteine metabolism (HP:0010919)2.43235827
50Nephronophthisis (HP:0000090)2.41897537
51Dysmetric saccades (HP:0000641)2.39499527
52Abnormality of the lower motor neuron (HP:0002366)2.39467179
53Apathy (HP:0000741)2.39218108
54Retinal dysplasia (HP:0007973)2.38349202
55Hammertoe (HP:0001765)2.38079617
56Molar tooth sign on MRI (HP:0002419)2.36629255
57Abnormality of midbrain morphology (HP:0002418)2.36629255
58Aplasia involving bones of the upper limbs (HP:0009823)2.35995833
59Aplasia of the phalanges of the hand (HP:0009802)2.35995833
60Aplasia involving bones of the extremities (HP:0009825)2.35995833
61Papillary thyroid carcinoma (HP:0002895)2.35792798
62Gait imbalance (HP:0002141)2.35722057
63Menstrual irregularities (HP:0000858)2.33452348
64Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.33037715
65Ventricular fibrillation (HP:0001663)2.30494863
66Hepatoblastoma (HP:0002884)2.29424765
67Cerebellar dysplasia (HP:0007033)2.29043346
68Dysmetria (HP:0001310)2.29022576
69Poor coordination (HP:0002370)2.25781455
70Aplasia/Hypoplasia of the brainstem (HP:0007362)2.22854895
71Hypoplasia of the brainstem (HP:0002365)2.22854895
72Inability to walk (HP:0002540)2.21994783
73Poor eye contact (HP:0000817)2.21361831
74Pancreatic fibrosis (HP:0100732)2.16163069
75Vitreoretinal degeneration (HP:0000655)2.16068780
76Fetal akinesia sequence (HP:0001989)2.15675206
77Impaired vibratory sensation (HP:0002495)2.15501643
78Bradycardia (HP:0001662)2.14860798
79Segmental peripheral demyelination/remyelination (HP:0003481)2.13480875
80Esophageal atresia (HP:0002032)2.12941122
81Epileptiform EEG discharges (HP:0011182)2.12720547
82Fibular aplasia (HP:0002990)2.12308389
83Abnormal eating behavior (HP:0100738)2.11176068
84Vaginal atresia (HP:0000148)2.10997250
85Short tibia (HP:0005736)2.09499471
86Akinesia (HP:0002304)2.08801573
87Amyotrophic lateral sclerosis (HP:0007354)2.08504213
88Optic nerve hypoplasia (HP:0000609)2.07550194
89Abnormality of ocular smooth pursuit (HP:0000617)2.06744281
90Neoplasm of the peripheral nervous system (HP:0100007)2.06600634
91Genital tract atresia (HP:0001827)2.06182530
92Limb dystonia (HP:0002451)2.05632403
93Esotropia (HP:0000565)2.05427294
94Bradykinesia (HP:0002067)2.04798150
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03840154
96Degeneration of the lateral corticospinal tracts (HP:0002314)2.03840154
97Diminished motivation (HP:0000745)2.03472104
98Broad-based gait (HP:0002136)2.02722468
99EEG with generalized epileptiform discharges (HP:0011198)2.02702856
100Nephrogenic diabetes insipidus (HP:0009806)2.02201240
101Lower limb muscle weakness (HP:0007340)2.02165820
102Congenital primary aphakia (HP:0007707)2.01578251
103Steppage gait (HP:0003376)2.01385135
104Decreased motor nerve conduction velocity (HP:0003431)2.00822155
105Lissencephaly (HP:0001339)2.00140376
106Postural instability (HP:0002172)1.99774480
107Foot dorsiflexor weakness (HP:0009027)1.98772776
108Intellectual disability, moderate (HP:0002342)1.98520508
109Generalized hypotonia (HP:0001290)1.97519782
110Chorioretinal atrophy (HP:0000533)1.97373929
111Occipital encephalocele (HP:0002085)1.95295823
112Renovascular hypertension (HP:0100817)1.94643710
113Hypercortisolism (HP:0001578)1.92422449
114Absent speech (HP:0001344)1.92369884
115Protruding tongue (HP:0010808)1.91890974
116Hypsarrhythmia (HP:0002521)1.91644373
117Dysautonomia (HP:0002459)1.91291564
118Exotropia (HP:0000577)1.91209467
119Midline defect of the nose (HP:0004122)1.90503904
120Hypoventilation (HP:0002791)1.89851588
121Reticulocytopenia (HP:0001896)1.88983431
122Distal sensory impairment (HP:0002936)1.88628732
123Agitation (HP:0000713)1.87491955
124Astrocytoma (HP:0009592)1.86460754
125Abnormality of the astrocytes (HP:0100707)1.86460754
126Torticollis (HP:0000473)1.86046107
127Anosmia (HP:0000458)1.85016415
128Thyroid carcinoma (HP:0002890)1.84838529
129Abnormality of the renal medulla (HP:0100957)1.83026539
130Hemiparesis (HP:0001269)1.82244675
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.81038351
132Medial flaring of the eyebrow (HP:0010747)1.80452838
133Cutaneous finger syndactyly (HP:0010554)1.79829935
134Submucous cleft hard palate (HP:0000176)1.78864517
135Hemiplegia (HP:0002301)1.78831976
136Abnormality of saccadic eye movements (HP:0000570)1.78672831
137Specific learning disability (HP:0001328)1.77729585
138Type II lissencephaly (HP:0007260)1.77251860
139Autoamputation (HP:0001218)1.76007638
140True hermaphroditism (HP:0010459)1.74907878
141Restlessness (HP:0000711)1.72083047
142Intellectual disability, severe (HP:0010864)1.71633059
143Anencephaly (HP:0002323)1.71167890
144Cutaneous syndactyly (HP:0012725)1.69355971
145Epidermoid cyst (HP:0200040)1.68793679
146Abnormality of the pubic bones (HP:0003172)1.68641994
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67781048
148Impulsivity (HP:0100710)1.67058804
149Poor suck (HP:0002033)1.66838231
150Partial duplication of thumb phalanx (HP:0009944)1.65242946
151Abnormality of salivation (HP:0100755)1.64875964
152Narrow forehead (HP:0000341)1.64466646
153Progressive inability to walk (HP:0002505)1.61942128
154Bony spicule pigmentary retinopathy (HP:0007737)1.60931317
155Glioma (HP:0009733)1.60691721
156Absent eyebrow (HP:0002223)1.60349496
157Tubulointerstitial nephritis (HP:0001970)1.60265136
158Neoplasm of the adrenal cortex (HP:0100641)1.59685690
159Pancreatic cysts (HP:0001737)1.59087272
160Obsessive-compulsive behavior (HP:0000722)1.58266955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.19672080
2CASK4.06895040
3MINK13.65700177
4MAP3K43.03661478
5MAP3K92.93894703
6WNK32.84976929
7MAP2K72.68142637
8SRPK12.35364660
9NTRK12.35098987
10MAP3K122.31596991
11STK38L2.22535518
12BRD42.15641871
13LMTK22.15632471
14MARK12.10761774
15MAP2K42.09765206
16LATS12.01521621
17PLK21.92629155
18EPHA41.87931900
19MAPK131.85185819
20CAMK1G1.77367097
21TRIM281.77364313
22TYRO31.68653976
23SGK21.59649207
24RIPK11.57668949
25AKT31.52920406
26KSR21.49849183
27PAK61.49738049
28CAMK1D1.46607297
29SGK4941.45503131
30SGK2231.45503131
31ZAK1.44448233
32PLK41.39017415
33MKNK21.37247853
34BRSK21.36651961
35CDK51.36357692
36PRKCG1.35562682
37RIPK41.34731728
38LATS21.34020585
39PHKG11.32120751
40PHKG21.32120751
41TESK11.26494912
42DAPK21.24123882
43CDC71.16370889
44CCNB11.11229292
45GRK51.10462802
46WNK11.10400823
47UHMK11.10275465
48DAPK11.09648358
49SGK31.08574586
50TNK21.06340032
51CSNK1G11.04426456
52FRK1.04350642
53MAP3K21.03550605
54KSR11.02582320
55WEE11.01659286
56BMPR1B1.01620019
57GRK70.97910911
58SCYL20.97228347
59MAP3K50.95588900
60PDPK10.95556084
61CSNK1G30.94645739
62INSRR0.93602683
63SIK30.91418643
64FGFR20.90451200
65CSNK1A1L0.90057517
66CAMK2A0.89922055
67PDK10.89520911
68CAMKK10.88633823
69NTRK20.87602786
70PNCK0.86066622
71MELK0.85617452
72PRKCH0.84045249
73CDK30.83239765
74ARAF0.83181948
75RET0.80460640
76TSSK60.80354795
77MAP4K20.79942486
78MAPKAPK30.79381543
79BMPR20.79035343
80MAP2K10.78516407
81CDK190.77252590
82CDK180.76084425
83DYRK1A0.74823222
84CAMKK20.74528845
85CSNK1G20.74030024
86CDK140.73148550
87ERBB30.72752612
88SGK10.71897429
89PRPF4B0.71534934
90NEK60.71269562
91NEK90.69173604
92MAP3K100.68731763
93CDK150.68188447
94TNIK0.67598250
95MATK0.67232293
96MET0.66935573
97SIK20.66671106
98EPHB20.66267001
99RPS6KA20.66055742
100PINK10.65877066
101BRAF0.65867663
102ADRBK10.65169371
103BRSK10.64931742
104EPHA30.64662601
105STK390.61350883
106JAK10.60422425
107FER0.59793824
108CDK11A0.59627699
109PIK3CA0.59626206
110ERBB40.57990689
111CAMK40.57243440
112PTK2B0.56248028
113MAP3K60.56099825
114FES0.56084761
115TAF10.56027099
116LIMK10.55677468
117CAMK2B0.55578152
118CAMK2D0.54862197
119WNK40.54315297
120MKNK10.53938266
121ROCK20.53789729
122MAP3K10.52892410
123PRKCE0.51128408
124RPS6KB10.50724112
125CAMK10.50230650
126CAMK2G0.49997768
127PAK30.49686277
128CSNK1E0.49585618
129TTK0.49417954
130DYRK20.49348042
131OXSR10.48911971
132RPS6KA40.48680544
133PRKAA10.48448851
134STK380.48344074
135MARK20.47307428
136CSNK1D0.46952049
137ATM0.46461056
138PRKCZ0.46331981
139RPS6KA30.45932742
140BCR0.45899174
141PDK30.45780742
142PDK40.45780742
143PRKD30.44495592
144PRKG10.44412545
145DYRK30.44179716
146MAP3K130.43681074
147FGR0.43313326
148NEK10.43145574
149PRKCI0.43049178
150ADRBK20.42840489
151PLK10.42677053
152STK240.42426995
153PRKACB0.41635900
154PKN10.41485658
155GRK10.40037103
156STK30.39981510
157MST1R0.39717234
158GSK3B0.37624676
159ICK0.35407626
160PRKDC0.34079190

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.52720651
2Nicotine addiction_Homo sapiens_hsa050333.28854497
3Olfactory transduction_Homo sapiens_hsa047402.87233019
4Long-term potentiation_Homo sapiens_hsa047202.63965402
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48458088
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.45565360
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.45025036
8Circadian entrainment_Homo sapiens_hsa047132.39321812
9Dopaminergic synapse_Homo sapiens_hsa047282.35647393
10Amphetamine addiction_Homo sapiens_hsa050312.33057045
11Glutamatergic synapse_Homo sapiens_hsa047242.28657646
12GABAergic synapse_Homo sapiens_hsa047272.25940998
13Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.21083160
14Fatty acid biosynthesis_Homo sapiens_hsa000612.12189623
15Insulin secretion_Homo sapiens_hsa049111.99048979
16Taste transduction_Homo sapiens_hsa047421.97629987
17Morphine addiction_Homo sapiens_hsa050321.95972726
18Salivary secretion_Homo sapiens_hsa049701.88544633
19Cholinergic synapse_Homo sapiens_hsa047251.83787061
20Collecting duct acid secretion_Homo sapiens_hsa049661.83763331
21Serotonergic synapse_Homo sapiens_hsa047261.83459971
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74704820
23Gastric acid secretion_Homo sapiens_hsa049711.72251715
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67367741
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65748736
26Steroid biosynthesis_Homo sapiens_hsa001001.64177883
27Renin secretion_Homo sapiens_hsa049241.60438611
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.55189795
29GnRH signaling pathway_Homo sapiens_hsa049121.53662222
30Oxytocin signaling pathway_Homo sapiens_hsa049211.50151824
31Basal transcription factors_Homo sapiens_hsa030221.38930543
32Calcium signaling pathway_Homo sapiens_hsa040201.38596873
33Hippo signaling pathway_Homo sapiens_hsa043901.37830831
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34661071
35Vibrio cholerae infection_Homo sapiens_hsa051101.32246789
36Long-term depression_Homo sapiens_hsa047301.28263402
37Selenocompound metabolism_Homo sapiens_hsa004501.27622666
38ErbB signaling pathway_Homo sapiens_hsa040121.24212514
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21207053
40Gap junction_Homo sapiens_hsa045401.20581141
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18165041
42Cocaine addiction_Homo sapiens_hsa050301.17430649
43Regulation of autophagy_Homo sapiens_hsa041401.14453133
44Axon guidance_Homo sapiens_hsa043601.14111422
45Cardiac muscle contraction_Homo sapiens_hsa042601.12491685
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.07768864
47Glioma_Homo sapiens_hsa052141.05075724
48Tight junction_Homo sapiens_hsa045301.04714232
49Oocyte meiosis_Homo sapiens_hsa041141.03598202
50Phototransduction_Homo sapiens_hsa047441.02567643
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01850071
52Oxidative phosphorylation_Homo sapiens_hsa001901.01785004
53Alzheimers disease_Homo sapiens_hsa050101.01686506
54Propanoate metabolism_Homo sapiens_hsa006401.01476524
55Melanogenesis_Homo sapiens_hsa049161.00571112
56cAMP signaling pathway_Homo sapiens_hsa040241.00188425
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98156005
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96001238
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95260063
60Dorso-ventral axis formation_Homo sapiens_hsa043200.92842853
61Glucagon signaling pathway_Homo sapiens_hsa049220.92660702
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92595313
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90030702
64Estrogen signaling pathway_Homo sapiens_hsa049150.89924611
65Fatty acid metabolism_Homo sapiens_hsa012120.87034018
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86570444
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.85642931
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84172496
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83609315
70Type II diabetes mellitus_Homo sapiens_hsa049300.82825064
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.82443488
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80467316
73TGF-beta signaling pathway_Homo sapiens_hsa043500.80424235
74Non-homologous end-joining_Homo sapiens_hsa034500.80048230
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76008391
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75877734
77Caffeine metabolism_Homo sapiens_hsa002320.74647851
78Tryptophan metabolism_Homo sapiens_hsa003800.74474749
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73882134
80Fanconi anemia pathway_Homo sapiens_hsa034600.73874883
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72127282
82MAPK signaling pathway_Homo sapiens_hsa040100.72124483
83Parkinsons disease_Homo sapiens_hsa050120.71290651
84Thyroid hormone synthesis_Homo sapiens_hsa049180.69709647
85Protein export_Homo sapiens_hsa030600.68821760
86Pancreatic secretion_Homo sapiens_hsa049720.64200608
87VEGF signaling pathway_Homo sapiens_hsa043700.64193348
88Dilated cardiomyopathy_Homo sapiens_hsa054140.61952497
89Basal cell carcinoma_Homo sapiens_hsa052170.61357145
90Pyruvate metabolism_Homo sapiens_hsa006200.60989965
91Histidine metabolism_Homo sapiens_hsa003400.60726553
92beta-Alanine metabolism_Homo sapiens_hsa004100.59535423
93RNA transport_Homo sapiens_hsa030130.58920303
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55696956
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55234313
96Hedgehog signaling pathway_Homo sapiens_hsa043400.55181966
97mRNA surveillance pathway_Homo sapiens_hsa030150.55174797
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53305777
99Bile secretion_Homo sapiens_hsa049760.51263862
100Ras signaling pathway_Homo sapiens_hsa040140.50869041
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.50022316
102Vitamin B6 metabolism_Homo sapiens_hsa007500.48246153
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47746077
104Phagosome_Homo sapiens_hsa041450.46560785
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.46343316
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45988157
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45340855
108Insulin signaling pathway_Homo sapiens_hsa049100.44662872
109Adherens junction_Homo sapiens_hsa045200.43578757
110Prion diseases_Homo sapiens_hsa050200.42248670
111Phenylalanine metabolism_Homo sapiens_hsa003600.41916973
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41139072
113Rap1 signaling pathway_Homo sapiens_hsa040150.41104558
114Huntingtons disease_Homo sapiens_hsa050160.40673267
115Fatty acid elongation_Homo sapiens_hsa000620.40474703
116mTOR signaling pathway_Homo sapiens_hsa041500.39728797
117Inositol phosphate metabolism_Homo sapiens_hsa005620.39344477
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39155814
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36432529
120Fatty acid degradation_Homo sapiens_hsa000710.36161553
121Endometrial cancer_Homo sapiens_hsa052130.35329524
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35072253
123Salmonella infection_Homo sapiens_hsa051320.34481451
124Thyroid cancer_Homo sapiens_hsa052160.33856401
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.33500749
126AMPK signaling pathway_Homo sapiens_hsa041520.32994154
127Wnt signaling pathway_Homo sapiens_hsa043100.32843990
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32255358
129Renal cell carcinoma_Homo sapiens_hsa052110.32147293
130Choline metabolism in cancer_Homo sapiens_hsa052310.32119542
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30731944
132Melanoma_Homo sapiens_hsa052180.30192283
133Alcoholism_Homo sapiens_hsa050340.29861848
134Endocytosis_Homo sapiens_hsa041440.29647700
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29539608
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29089265
137Butanoate metabolism_Homo sapiens_hsa006500.28620818
138Sphingolipid metabolism_Homo sapiens_hsa006000.27786079
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26096981
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25606867

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