PCDHB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.82606189
2protein localization to synapse (GO:0035418)5.19152431
3platelet dense granule organization (GO:0060155)5.12716863
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05677315
5vocalization behavior (GO:0071625)4.85298221
6behavioral response to nicotine (GO:0035095)4.84433091
7neurotransmitter-gated ion channel clustering (GO:0072578)4.76669765
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69490297
9synaptic vesicle exocytosis (GO:0016079)4.67740171
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58345025
11presynaptic membrane assembly (GO:0097105)4.54341193
12neuron recognition (GO:0008038)4.47866687
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.33532722
14regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.33220490
15postsynaptic membrane organization (GO:0001941)4.31887195
16regulation of synaptic vesicle exocytosis (GO:2000300)4.27095218
17layer formation in cerebral cortex (GO:0021819)4.26331230
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24860604
19L-fucose catabolic process (GO:0042355)4.24547430
20fucose catabolic process (GO:0019317)4.24547430
21L-fucose metabolic process (GO:0042354)4.24547430
22glutamate receptor signaling pathway (GO:0007215)4.20781767
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.09882278
24regulation of glutamate receptor signaling pathway (GO:1900449)4.08434346
25presynaptic membrane organization (GO:0097090)4.03706339
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.00572156
27innervation (GO:0060384)3.99573772
28cellular potassium ion homeostasis (GO:0030007)3.98014677
29regulation of hexokinase activity (GO:1903299)3.94849628
30regulation of glucokinase activity (GO:0033131)3.94849628
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93238770
32atrial cardiac muscle cell action potential (GO:0086014)3.92805001
33glutamate secretion (GO:0014047)3.87531184
34response to pheromone (GO:0019236)3.86374440
35axonal fasciculation (GO:0007413)3.82162012
36nucleobase catabolic process (GO:0046113)3.76460472
37mating behavior (GO:0007617)3.76353071
38axoneme assembly (GO:0035082)3.73118399
39positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.70791953
40locomotory exploration behavior (GO:0035641)3.70766117
41positive regulation of synapse maturation (GO:0090129)3.70430731
42regulation of synaptic transmission, glutamatergic (GO:0051966)3.69183903
43regulation of synaptic vesicle transport (GO:1902803)3.68288665
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.68162335
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64675043
46* synapse assembly (GO:0007416)3.62140065
47neuron-neuron synaptic transmission (GO:0007270)3.60448563
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.56713436
49dendrite morphogenesis (GO:0048813)3.56186856
50cell communication by electrical coupling (GO:0010644)3.54395218
51transmission of nerve impulse (GO:0019226)3.50296599
52protein K6-linked ubiquitination (GO:0085020)3.50263935
53exploration behavior (GO:0035640)3.49043085
54nonmotile primary cilium assembly (GO:0035058)3.48167810
55dendritic spine morphogenesis (GO:0060997)3.48116599
56synaptic vesicle maturation (GO:0016188)3.46897476
57striatum development (GO:0021756)3.46199107
58water-soluble vitamin biosynthetic process (GO:0042364)3.44879825
59synaptic transmission, glutamatergic (GO:0035249)3.44809291
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42491878
61cerebellar granule cell differentiation (GO:0021707)3.42254251
62detection of light stimulus involved in visual perception (GO:0050908)3.41444271
63detection of light stimulus involved in sensory perception (GO:0050962)3.41444271
64cell migration in hindbrain (GO:0021535)3.41213420
65dopamine transport (GO:0015872)3.35171542
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32781602
67cellular ketone body metabolic process (GO:0046950)3.32721826
68behavioral response to cocaine (GO:0048148)3.32262602
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32008083
70cornea development in camera-type eye (GO:0061303)3.31034846
71long-term synaptic potentiation (GO:0060291)3.30340187
72nephron epithelium morphogenesis (GO:0072088)3.28668150
73nephron tubule morphogenesis (GO:0072078)3.28668150
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28540430
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27746231
76neurotransmitter secretion (GO:0007269)3.25851951
77startle response (GO:0001964)3.24688569
78positive regulation of synapse assembly (GO:0051965)3.21000992
79kidney morphogenesis (GO:0060993)3.20802131
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19828152
81regulation of postsynaptic membrane potential (GO:0060078)3.19790659
82regulation of synapse structural plasticity (GO:0051823)3.17236119
83epithelial cilium movement (GO:0003351)3.16826728
84female mating behavior (GO:0060180)3.16206468
85response to histamine (GO:0034776)3.15898123
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.14977856
87regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14350055
88regulation of female receptivity (GO:0045924)3.10901855
89regulation of neuronal synaptic plasticity (GO:0048168)3.10143234
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.09803344
91regulation of dendritic spine morphogenesis (GO:0061001)3.06542731
92indolalkylamine metabolic process (GO:0006586)3.06095832
93regulation of synapse maturation (GO:0090128)3.05469117
94behavioral fear response (GO:0001662)3.03223230
95behavioral defense response (GO:0002209)3.03223230
96* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02461244
97positive regulation of membrane potential (GO:0045838)3.01505647
98ketone body metabolic process (GO:1902224)3.01230304
99neuronal action potential propagation (GO:0019227)3.00774413
100behavioral response to ethanol (GO:0048149)2.98486499
101prepulse inhibition (GO:0060134)2.98139252
102proline transport (GO:0015824)2.97830900
103limb bud formation (GO:0060174)2.96098993
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95687241
105pyrimidine nucleobase catabolic process (GO:0006208)2.95196333
106gamma-aminobutyric acid transport (GO:0015812)2.92274159
107fear response (GO:0042596)2.90730208
108glycerophospholipid catabolic process (GO:0046475)2.89960070
109* synapse organization (GO:0050808)2.89836286
110regulation of synaptic transmission, GABAergic (GO:0032228)2.88801194
111long-term memory (GO:0007616)2.88041099
112positive regulation of neurotransmitter secretion (GO:0001956)2.87928355
113membrane hyperpolarization (GO:0060081)2.87793916
114protein import into peroxisome matrix (GO:0016558)2.87532561
115auditory receptor cell differentiation (GO:0042491)2.85462626
116central nervous system projection neuron axonogenesis (GO:0021952)2.84544784
117protein complex biogenesis (GO:0070271)2.84044824
118potassium ion homeostasis (GO:0055075)2.83957691
119regulation of synaptic plasticity (GO:0048167)2.83746379
120anterograde synaptic vesicle transport (GO:0048490)2.82884661
121regulation of neurotransmitter secretion (GO:0046928)2.82839320
122response to auditory stimulus (GO:0010996)2.82502779
123regulation of dendritic spine development (GO:0060998)2.82348469
124synaptic vesicle endocytosis (GO:0048488)2.81571214
125regulation of vesicle fusion (GO:0031338)2.81406172
126protein polyglutamylation (GO:0018095)2.81306305
127positive regulation of mitochondrial fission (GO:0090141)2.81278532
128positive regulation of dendritic spine development (GO:0060999)2.80900094
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.79266965
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78868664
131renal tubule morphogenesis (GO:0061333)2.78035824
132multi-organism reproductive behavior (GO:0044705)2.77649041
133piRNA metabolic process (GO:0034587)2.76451955
134neurotransmitter transport (GO:0006836)2.75354955
135regulation of synapse assembly (GO:0051963)2.75282327
136reproductive behavior (GO:0019098)2.74933945
137membrane depolarization during action potential (GO:0086010)2.74386174
138long term synaptic depression (GO:0060292)2.72567425
139indolalkylamine catabolic process (GO:0046218)2.70811495
140tryptophan catabolic process (GO:0006569)2.70811495
141indole-containing compound catabolic process (GO:0042436)2.70811495
142neuronal action potential (GO:0019228)2.70807347
143G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70443347
144protein K11-linked deubiquitination (GO:0035871)2.69990390
145cilium movement (GO:0003341)2.65127061
146regulation of cilium movement (GO:0003352)2.64776569
147photoreceptor cell maintenance (GO:0045494)2.64510187
148synaptic transmission, cholinergic (GO:0007271)2.62606239
149retinal ganglion cell axon guidance (GO:0031290)2.62210833
150respiratory chain complex IV assembly (GO:0008535)2.61394676
151cilium morphogenesis (GO:0060271)2.61322354
152cilium organization (GO:0044782)2.61271642
153inner ear receptor stereocilium organization (GO:0060122)2.60272665
154kynurenine metabolic process (GO:0070189)2.59851654
155neuron fate determination (GO:0048664)2.58423536
156catecholamine transport (GO:0051937)2.55248775
157cilium assembly (GO:0042384)2.54909243
158reflex (GO:0060004)2.54880595
159mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54565626
160mitochondrial respiratory chain complex I assembly (GO:0032981)2.54565626
161NADH dehydrogenase complex assembly (GO:0010257)2.54565626
162cytochrome complex assembly (GO:0017004)2.54430488
163mitochondrial respiratory chain complex assembly (GO:0033108)2.53130238
164inositol phosphate catabolic process (GO:0071545)2.52675820
165photoreceptor cell development (GO:0042461)2.51620851
166intraciliary transport (GO:0042073)2.51250469
167tryptophan metabolic process (GO:0006568)2.48282617
168establishment of protein localization to mitochondrial membrane (GO:0090151)2.47840607
169hindbrain development (GO:0030902)2.46981858
170DNA methylation involved in gamete generation (GO:0043046)2.44531445
171preassembly of GPI anchor in ER membrane (GO:0016254)2.40973703
172spinal cord motor neuron differentiation (GO:0021522)2.40798688
173neural tube formation (GO:0001841)2.39800511
174regulation of action potential (GO:0098900)2.39783995
175tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38872241
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.38872241
177positive regulation of oligodendrocyte differentiation (GO:0048714)2.38756454
178indole-containing compound metabolic process (GO:0042430)2.38363956
179somite development (GO:0061053)2.38299559
180retinal cone cell development (GO:0046549)2.37629807
181primary amino compound metabolic process (GO:1901160)2.36929493
182anterograde axon cargo transport (GO:0008089)2.36603022
183endocrine pancreas development (GO:0031018)2.36446260
184inositol phosphate dephosphorylation (GO:0046855)2.33904175
185phosphorylated carbohydrate dephosphorylation (GO:0046838)2.33904175
186replication fork processing (GO:0031297)2.33059786
187retina development in camera-type eye (GO:0060041)2.32395238
188positive regulation of meiosis (GO:0045836)2.30874377
189embryonic epithelial tube formation (GO:0001838)2.30541414
190response to nitrosative stress (GO:0051409)2.29990342
191peptidyl-histidine modification (GO:0018202)2.29551817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16266174
2GBX2_23144817_ChIP-Seq_PC3_Human4.11660196
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93098099
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85707049
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84692818
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83375534
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82208981
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.68834301
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46295663
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44945134
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44945134
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40866391
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35710398
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27885608
15REST_21632747_ChIP-Seq_MESCs_Mouse2.27662578
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25282785
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24286363
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23035847
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21634485
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.19332527
21EWS_26573619_Chip-Seq_HEK293_Human2.13859724
22TAF15_26573619_Chip-Seq_HEK293_Human2.13284282
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.10751979
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09066181
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06435030
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.05271380
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05150522
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.03261683
29DROSHA_22980978_ChIP-Seq_HELA_Human2.02896577
30AR_21572438_ChIP-Seq_LNCaP_Human1.97935413
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95551905
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90131357
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89508969
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.81257688
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80969436
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75940053
37P300_19829295_ChIP-Seq_ESCs_Human1.75819387
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.72026979
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.72015635
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69515241
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65881280
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64902560
43SMAD4_21799915_ChIP-Seq_A2780_Human1.64888548
44FUS_26573619_Chip-Seq_HEK293_Human1.63392818
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62314796
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.60421102
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.59292857
48IGF1R_20145208_ChIP-Seq_DFB_Human1.54636339
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54334670
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53351605
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52806931
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49548435
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49437086
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.49356039
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49306709
56VDR_22108803_ChIP-Seq_LS180_Human1.49280477
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49075542
58AR_25329375_ChIP-Seq_VCAP_Human1.48992358
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48928076
60ZNF274_21170338_ChIP-Seq_K562_Hela1.48183860
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47657016
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45680416
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.41111968
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38262606
65AHR_22903824_ChIP-Seq_MCF-7_Human1.36102673
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36081364
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.35711316
68NANOG_19829295_ChIP-Seq_ESCs_Human1.32488591
69SOX2_19829295_ChIP-Seq_ESCs_Human1.32488591
70STAT3_23295773_ChIP-Seq_U87_Human1.31462834
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31359573
72RNF2_27304074_Chip-Seq_NSC_Mouse1.31315541
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30322670
74TCF4_22108803_ChIP-Seq_LS180_Human1.30120716
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30008329
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28378840
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26946582
78BCAT_22108803_ChIP-Seq_LS180_Human1.25287936
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25105056
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24287936
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24251822
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.24181276
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24116789
84TP53_22573176_ChIP-Seq_HFKS_Human1.23286652
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21441830
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.21221569
87TP53_18474530_ChIP-ChIP_U2OS_Human1.21206550
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20998360
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20104840
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19963980
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18906196
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.18906196
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18251169
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.18238699
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.17226771
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.16976763
97RUNX2_22187159_ChIP-Seq_PCA_Human1.16431199
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15993212
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15223183
100TCF4_23295773_ChIP-Seq_U87_Human1.14782112
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13619385
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.13584162
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.12859530
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12124051
105TP53_16413492_ChIP-PET_HCT116_Human1.11893714
106AR_19668381_ChIP-Seq_PC3_Human1.11680445
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11382405
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09565066
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09375062
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08539043
111P53_22387025_ChIP-Seq_ESCs_Mouse1.08277932
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07452492
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07452492
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.06737198
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05666182
116* NCOR_22424771_ChIP-Seq_293T_Human1.05461135
117MYC_18940864_ChIP-ChIP_HL60_Human1.05298388
118ER_23166858_ChIP-Seq_MCF-7_Human1.04960540
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04690374
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03587796
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02372202
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01575600
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.01002862
124GATA3_21878914_ChIP-Seq_MCF-7_Human1.00725433
125IRF1_19129219_ChIP-ChIP_H3396_Human1.00504989
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.00112207
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00077434
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99721027
129HOXB7_26014856_ChIP-Seq_BT474_Human0.99382806
130CDX2_22108803_ChIP-Seq_LS180_Human0.98792225
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98423200
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98118839
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97417558
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97378018
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97290841
136CBP_20019798_ChIP-Seq_JUKART_Human0.97215367
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97215367
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.96930500
139JUN_21703547_ChIP-Seq_K562_Human0.96851040
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.96203995
141AR_20517297_ChIP-Seq_VCAP_Human0.95739016
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95530239
143KDM2B_26808549_Chip-Seq_REH_Human0.93234086
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92950794
145RXR_22108803_ChIP-Seq_LS180_Human0.90422192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.66521973
2MP0004859_abnormal_synaptic_plasticity4.09822281
3MP0003635_abnormal_synaptic_transmissio3.46130645
4MP0004270_analgesia3.27001290
5MP0009780_abnormal_chondrocyte_physiolo3.05409069
6MP0002063_abnormal_learning/memory/cond2.82611637
7MP0005423_abnormal_somatic_nervous2.82041460
8MP0008877_abnormal_DNA_methylation2.74357631
9MP0003195_calcinosis2.73811767
10MP0009745_abnormal_behavioral_response2.72871037
11MP0002064_seizures2.58200220
12MP0001968_abnormal_touch/_nociception2.51993573
13MP0009046_muscle_twitch2.42032249
14MP0002572_abnormal_emotion/affect_behav2.38749662
15MP0004858_abnormal_nervous_system2.34830474
16MP0002272_abnormal_nervous_system2.32482174
17MP0000778_abnormal_nervous_system2.27814495
18MP0002734_abnormal_mechanical_nocicepti2.25650775
19MP0005646_abnormal_pituitary_gland2.23953552
20MP0002938_white_spotting2.23724725
21MP0001440_abnormal_grooming_behavior2.23339105
22MP0005551_abnormal_eye_electrophysiolog2.20955051
23MP0002102_abnormal_ear_morphology2.18941370
24MP0001486_abnormal_startle_reflex2.17971434
25MP0001984_abnormal_olfaction2.17166850
26MP0002736_abnormal_nociception_after2.09756551
27MP0002638_abnormal_pupillary_reflex2.08669538
28MP0005174_abnormal_tail_pigmentation2.05623560
29MP0002184_abnormal_innervation2.05418128
30MP0005645_abnormal_hypothalamus_physiol2.02819607
31MP0006276_abnormal_autonomic_nervous1.99631472
32MP0006072_abnormal_retinal_apoptosis1.96923718
33MP0002067_abnormal_sensory_capabilities1.87591650
34MP0000372_irregular_coat_pigmentation1.84385994
35MP0002653_abnormal_ependyma_morphology1.82677479
36MP0005379_endocrine/exocrine_gland_phen1.79029673
37MP0000569_abnormal_digit_pigmentation1.75140049
38MP0002163_abnormal_gland_morphology1.71702976
39MP0002735_abnormal_chemical_nociception1.71612258
40MP0002557_abnormal_social/conspecific_i1.67985766
41MP0005386_behavior/neurological_phenoty1.67944317
42MP0004924_abnormal_behavior1.67944317
43MP0002733_abnormal_thermal_nociception1.62885784
44MP0001529_abnormal_vocalization1.60608457
45MP0001501_abnormal_sleep_pattern1.59018668
46MP0002928_abnormal_bile_duct1.56869344
47MP0003329_amyloid_beta_deposits1.53292533
48MP0001502_abnormal_circadian_rhythm1.53264867
49MP0003283_abnormal_digestive_organ1.51076052
50MP0008872_abnormal_physiological_respon1.50746864
51MP0001188_hyperpigmentation1.50421395
52MP0002882_abnormal_neuron_morphology1.50370339
53MP0002138_abnormal_hepatobiliary_system1.50232152
54MP0000427_abnormal_hair_cycle1.50005533
55MP0003879_abnormal_hair_cell1.48256623
56MP0005084_abnormal_gallbladder_morpholo1.47462263
57MP0004215_abnormal_myocardial_fiber1.46455511
58MP0001970_abnormal_pain_threshold1.46379692
59MP0000955_abnormal_spinal_cord1.46155379
60MP0004133_heterotaxia1.43199492
61MP0003121_genomic_imprinting1.43109317
62MP0000631_abnormal_neuroendocrine_gland1.39127364
63MP0008569_lethality_at_weaning1.36931810
64MP0002822_catalepsy1.36637144
65MP0000015_abnormal_ear_pigmentation1.35343333
66MP0008875_abnormal_xenobiotic_pharmacok1.33724863
67MP0005253_abnormal_eye_physiology1.31539768
68MP0004811_abnormal_neuron_physiology1.30743934
69MP0001986_abnormal_taste_sensitivity1.27403924
70MP0003011_delayed_dark_adaptation1.26637583
71MP0001324_abnormal_eye_pigmentation1.24960582
72MP0002066_abnormal_motor_capabilities/c1.22826470
73MP0004885_abnormal_endolymph1.21869163
74MP0005499_abnormal_olfactory_system1.21319148
75MP0005394_taste/olfaction_phenotype1.21319148
76MP0002909_abnormal_adrenal_gland1.17764425
77MP0005075_abnormal_melanosome_morpholog1.16559966
78MP0001944_abnormal_pancreas_morphology1.16311828
79MP0005248_abnormal_Harderian_gland1.15598812
80MP0002752_abnormal_somatic_nervous1.14642033
81MP0002837_dystrophic_cardiac_calcinosis1.13970732
82MP0004147_increased_porphyrin_level1.13856892
83MP0002152_abnormal_brain_morphology1.12938906
84MP0003787_abnormal_imprinting1.12799463
85MP0000751_myopathy1.11913412
86MP0002095_abnormal_skin_pigmentation1.10802841
87MP0002229_neurodegeneration1.09685857
88MP0005409_darkened_coat_color1.09396829
89MP0003137_abnormal_impulse_conducting1.09076736
90MP0010386_abnormal_urinary_bladder1.08067096
91MP0002090_abnormal_vision1.07070908
92MP0005391_vision/eye_phenotype1.04637900
93MP0004742_abnormal_vestibular_system1.02611754
94MP0008789_abnormal_olfactory_epithelium1.00810399
95MP0003690_abnormal_glial_cell1.00058581
96MP0008995_early_reproductive_senescence0.99370244
97MP0002876_abnormal_thyroid_physiology0.98938226
98MP0005389_reproductive_system_phenotype0.98888243
99MP0001919_abnormal_reproductive_system0.98772173
100MP0003122_maternal_imprinting0.98449814
101MP0003634_abnormal_glial_cell0.98298242
102MP0004085_abnormal_heartbeat0.97027617
103MP0002160_abnormal_reproductive_system0.96091298
104MP0006292_abnormal_olfactory_placode0.93896919
105MP0003646_muscle_fatigue0.92816078
106MP0002254_reproductive_system_inflammat0.92655210
107MP0005195_abnormal_posterior_eye0.92055243
108MP0001905_abnormal_dopamine_level0.91926661
109MP0001963_abnormal_hearing_physiology0.90972135
110MP0002234_abnormal_pharynx_morphology0.89266045
111MP0005220_abnormal_exocrine_pancreas0.86058756
112MP0000026_abnormal_inner_ear0.86003194
113MP0002693_abnormal_pancreas_physiology0.85456555
114MP0003567_abnormal_fetal_cardiomyocyte0.85189424
115MP0005367_renal/urinary_system_phenotyp0.85147243
116MP0000516_abnormal_urinary_system0.85147243
117MP0000566_synostosis0.84728628
118MP0001177_atelectasis0.84672927
119MP0004142_abnormal_muscle_tone0.83254200
120MP0003878_abnormal_ear_physiology0.82463255
121MP0005377_hearing/vestibular/ear_phenot0.82463255
122MP0003633_abnormal_nervous_system0.82401988
123MP0003937_abnormal_limbs/digits/tail_de0.81791832
124MP0004233_abnormal_muscle_weight0.80964610
125MP0009384_cardiac_valve_regurgitation0.80663095
126MP0004145_abnormal_muscle_electrophysio0.77623338
127MP0002069_abnormal_eating/drinking_beha0.76339709
128MP0003631_nervous_system_phenotype0.76318560
129MP0004043_abnormal_pH_regulation0.76120267
130MP0001485_abnormal_pinna_reflex0.72937261
131MP0003861_abnormal_nervous_system0.72850547
132MP0001299_abnormal_eye_distance/0.72570632
133MP0003938_abnormal_ear_development0.72069454
134MP0003183_abnormal_peptide_metabolism0.70049691
135MP0001943_abnormal_respiration0.68605266
136MP0000013_abnormal_adipose_tissue0.66184559
137MP0000920_abnormal_myelination0.66013067
138MP0005171_absent_coat_pigmentation0.63185641
139MP0002751_abnormal_autonomic_nervous0.62870341
140MP0003632_abnormal_nervous_system0.61824201
141MP0003136_yellow_coat_color0.61557390
142MP0005620_abnormal_muscle_contractility0.58507517
143MP0005535_abnormal_body_temperature0.58352226

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.27374479
2Atonic seizures (HP:0010819)4.59933677
3Epileptic encephalopathy (HP:0200134)4.56877915
4Focal seizures (HP:0007359)4.37464303
5Aplasia involving bones of the upper limbs (HP:0009823)4.25948817
6Aplasia of the phalanges of the hand (HP:0009802)4.25948817
7Aplasia involving bones of the extremities (HP:0009825)4.25948817
8Pancreatic cysts (HP:0001737)4.05469013
9Absence seizures (HP:0002121)4.01357059
10Molar tooth sign on MRI (HP:0002419)3.88437517
11Abnormality of midbrain morphology (HP:0002418)3.88437517
12Febrile seizures (HP:0002373)3.86191680
13Pancreatic fibrosis (HP:0100732)3.79738359
14True hermaphroditism (HP:0010459)3.76360326
15Hyperventilation (HP:0002883)3.72598083
16Myokymia (HP:0002411)3.71721989
17Dialeptic seizures (HP:0011146)3.70100771
18Progressive cerebellar ataxia (HP:0002073)3.41295583
19Pigmentary retinal degeneration (HP:0001146)3.38938667
20Visual hallucinations (HP:0002367)3.32033768
21Medial flaring of the eyebrow (HP:0010747)3.27397983
22Nephronophthisis (HP:0000090)3.26157245
23Neurofibrillary tangles (HP:0002185)3.11765433
24Generalized tonic-clonic seizures (HP:0002069)3.07242673
25Central scotoma (HP:0000603)3.06284574
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.06068614
27Hypoplasia of the fovea (HP:0007750)3.06068614
28Hypothermia (HP:0002045)3.05494784
29Congenital stationary night blindness (HP:0007642)3.04441268
30Drooling (HP:0002307)3.02634573
31Excessive salivation (HP:0003781)3.02634573
32Abnormality of the renal cortex (HP:0011035)3.00059516
33Type II lissencephaly (HP:0007260)2.99921700
34Chronic hepatic failure (HP:0100626)2.98197322
35Abnormality of the renal medulla (HP:0100957)2.93882260
36Abnormality of macular pigmentation (HP:0008002)2.89353833
37Cerebral inclusion bodies (HP:0100314)2.88709878
38Pheochromocytoma (HP:0002666)2.85318617
39Narrow nasal bridge (HP:0000446)2.79100977
40Epileptiform EEG discharges (HP:0011182)2.78364139
41Abnormality of the corticospinal tract (HP:0002492)2.72559839
42Tubular atrophy (HP:0000092)2.68970109
43EEG with generalized epileptiform discharges (HP:0011198)2.67263181
44Supranuclear gaze palsy (HP:0000605)2.64058402
45Abnormality of the fovea (HP:0000493)2.61459155
46Hyperthyroidism (HP:0000836)2.60636369
47Broad-based gait (HP:0002136)2.60512754
48Synostosis involving the elbow (HP:0003938)2.59414318
49Humeroradial synostosis (HP:0003041)2.59414318
50Septo-optic dysplasia (HP:0100842)2.54408358
51Abnormal drinking behavior (HP:0030082)2.53503780
52Polydipsia (HP:0001959)2.53503780
53Aplasia/hypoplasia of the uterus (HP:0008684)2.53008753
54Abnormal rod and cone electroretinograms (HP:0008323)2.44891332
55Ankle clonus (HP:0011448)2.44440874
56Truncal ataxia (HP:0002078)2.44336796
57Hypoplastic left heart (HP:0004383)2.43719970
58Sclerocornea (HP:0000647)2.42688842
59Abnormality of binocular vision (HP:0011514)2.40460943
60Diplopia (HP:0000651)2.40460943
61Nephrogenic diabetes insipidus (HP:0009806)2.39868079
62Albinism (HP:0001022)2.39598585
63Attenuation of retinal blood vessels (HP:0007843)2.37540377
64Amblyopia (HP:0000646)2.37479711
65Progressive inability to walk (HP:0002505)2.36749290
66Hypoplasia of the uterus (HP:0000013)2.35677808
67Impaired social interactions (HP:0000735)2.33611572
68Abnormal social behavior (HP:0012433)2.33611572
69Cystic liver disease (HP:0006706)2.33468621
70Dysdiadochokinesis (HP:0002075)2.32466900
71Hypsarrhythmia (HP:0002521)2.29538896
72Increased corneal curvature (HP:0100692)2.28511441
73Keratoconus (HP:0000563)2.28511441
74Action tremor (HP:0002345)2.28088262
75Long nose (HP:0003189)2.27626871
76Blue irides (HP:0000635)2.25587834
77Impaired vibration sensation in the lower limbs (HP:0002166)2.25141373
78Choroideremia (HP:0001139)2.24797120
79Broad alveolar ridges (HP:0000187)2.24758683
80Inability to walk (HP:0002540)2.24615927
81Male pseudohermaphroditism (HP:0000037)2.23284860
82Thickened helices (HP:0000391)2.22410050
83Poor eye contact (HP:0000817)2.22341953
84Gait imbalance (HP:0002141)2.22089893
85Cubitus valgus (HP:0002967)2.22014997
86Neuroendocrine neoplasm (HP:0100634)2.21813771
87Oligodactyly (hands) (HP:0001180)2.21520459
88Shoulder girdle muscle weakness (HP:0003547)2.21365032
89Genital tract atresia (HP:0001827)2.20950792
90Dysmetria (HP:0001310)2.20120674
91Polyuria (HP:0000103)2.19055341
92Hemiparesis (HP:0001269)2.16483499
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.16470082
94Urinary bladder sphincter dysfunction (HP:0002839)2.16350003
95Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16267104
96Hypoplasia of the brainstem (HP:0002365)2.16267104
97Furrowed tongue (HP:0000221)2.15219771
98Intestinal atresia (HP:0011100)2.13861305
99Spastic gait (HP:0002064)2.12837203
100Congenital sensorineural hearing impairment (HP:0008527)2.12573976
101Large for gestational age (HP:0001520)2.11978193
102Abnormality of salivation (HP:0100755)2.11682625
103Lower limb muscle weakness (HP:0007340)2.11270719
104Amyotrophic lateral sclerosis (HP:0007354)2.11172185
105Gaze-evoked nystagmus (HP:0000640)2.11038747
106Absent speech (HP:0001344)2.10061908
107Pendular nystagmus (HP:0012043)2.09538368
108Maternal diabetes (HP:0009800)2.08935001
109Mixed hearing impairment (HP:0000410)2.08574025
110Progressive macrocephaly (HP:0004481)2.05303512
111Methylmalonic acidemia (HP:0002912)2.05258478
112Anxiety (HP:0000739)2.05175408
113Degeneration of the lateral corticospinal tracts (HP:0002314)2.04074365
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04074365
115Vaginal atresia (HP:0000148)2.03687133
116Postaxial foot polydactyly (HP:0001830)2.02449688
117Retinal dysplasia (HP:0007973)2.02368671
118Depression (HP:0000716)2.01796342
119Ketoacidosis (HP:0001993)2.01612851
120Abnormal eating behavior (HP:0100738)2.01389340
121Ketosis (HP:0001946)2.01347736
122Tachypnea (HP:0002789)1.99214501
123Abnormality of the labia minora (HP:0012880)1.99143477
124Hypoplastic heart (HP:0001961)1.98474673
125Anosmia (HP:0000458)1.98327590
126Neoplasm of the adrenal cortex (HP:0100641)1.98309821
127Tubulointerstitial fibrosis (HP:0005576)1.97474327
128Limb dystonia (HP:0002451)1.97386597
129Abolished electroretinogram (ERG) (HP:0000550)1.95252018
130Thyroiditis (HP:0100646)1.95046661
131Atrioventricular canal defect (HP:0006695)1.94809356
132Agitation (HP:0000713)1.94535347
133Anencephaly (HP:0002323)1.94236389
134Polyphagia (HP:0002591)1.91114860
135Lissencephaly (HP:0001339)1.90545808
136Hypomagnesemia (HP:0002917)1.90388721
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.90361377
138Postaxial hand polydactyly (HP:0001162)1.90300241
139Stereotypic behavior (HP:0000733)1.89881444
140Termporal pattern (HP:0011008)1.89707474
141Insidious onset (HP:0003587)1.89707474
142Optic nerve hypoplasia (HP:0000609)1.87845802
143Decreased circulating renin level (HP:0003351)1.87088470
144Methylmalonic aciduria (HP:0012120)1.86462831
145Pachygyria (HP:0001302)1.84673603
146Megalencephaly (HP:0001355)1.83936270
147Cutaneous syndactyly (HP:0012725)1.83878889
148Retinitis pigmentosa (HP:0000510)1.83385674
149Acute necrotizing encephalopathy (HP:0006965)1.82327909
150Congenital hepatic fibrosis (HP:0002612)1.81798398
151Abnormality of the columella (HP:0009929)1.81703036
152Genetic anticipation (HP:0003743)1.81051486
153Scotoma (HP:0000575)1.80271422
154Severe visual impairment (HP:0001141)1.80047436
155Rib fusion (HP:0000902)1.79588313
156Exotropia (HP:0000577)1.79410609
157Abnormal pancreas size (HP:0012094)1.78492695
158Urinary urgency (HP:0000012)1.78423558
159Widely spaced teeth (HP:0000687)1.78192772
160Abnormality of vitamin B metabolism (HP:0004340)1.78042611
161Poor coordination (HP:0002370)1.77792588
162Dry hair (HP:0011359)1.77473352
163Tubulointerstitial abnormality (HP:0001969)1.77427693
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.77202293
165Absent/shortened dynein arms (HP:0200106)1.77202293
166Mitochondrial inheritance (HP:0001427)1.77015077
167Postural instability (HP:0002172)1.76304124
168Aqueductal stenosis (HP:0002410)1.76268317
169Metaphyseal dysplasia (HP:0100255)1.76180643
170Tetraparesis (HP:0002273)1.75595293
171Bony spicule pigmentary retinopathy (HP:0007737)1.74822659
172Congenital primary aphakia (HP:0007707)1.74185826
173Anterior segment dysgenesis (HP:0007700)1.74116147
174Protruding tongue (HP:0010808)1.73482076
175Abnormal respiratory epithelium morphology (HP:0012253)1.72745357
176Abnormal respiratory motile cilium morphology (HP:0005938)1.72745357
177Acute encephalopathy (HP:0006846)1.72526323
178Decreased central vision (HP:0007663)1.71440934
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71269144
180Aplasia/Hypoplasia of the macula (HP:0008059)1.70881158
181Renal hypoplasia (HP:0000089)1.70335687
182Oligodactyly (HP:0012165)1.70067709
183Abnormal ciliary motility (HP:0012262)1.69383310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.11748298
2MARK14.19667786
3PINK14.14241221
4EPHA43.81837664
5NTRK33.57460196
6CASK3.36358974
7MAP3K43.10770106
8MAP4K23.01796524
9ADRBK22.61611239
10TNIK2.55826267
11PRKD32.48936817
12MAP3K92.43379699
13MINK12.33737237
14MAP2K72.31600129
15NTRK22.18898079
16GRK12.16506576
17NUAK12.08092496
18PAK62.06212820
19MAPK132.00019693
20PNCK1.76924123
21MAP3K121.70366386
22ZAK1.69545984
23DAPK21.66558669
24INSRR1.62833122
25MST41.60461359
26PRKCG1.58943266
27PAK31.58137457
28NTRK11.55609959
29MAP2K41.53534292
30SIK21.45507231
31FGFR21.43277143
32KSR11.39157647
33CDK51.38944585
34PLK21.38940032
35TRIM281.35945076
36MAP3K21.35417246
37MAPK121.28285292
38STK38L1.26659885
39KSR21.25634348
40CAMK2B1.25250271
41RIPK41.24270388
42CAMK2A1.24083963
43TLK11.23785507
44PHKG21.20546761
45PHKG11.20546761
46AKT31.19629928
47UHMK11.19499666
48ACVR1B1.17442790
49NEK61.17395806
50BCR1.17130910
51PRKCE1.16578199
52FER1.14408300
53GRK71.14297771
54MAPK71.10804227
55VRK21.09435116
56PRPF4B1.08029812
57FES1.07802311
58CAMK2D1.04162901
59MKNK21.03362030
60SGK2231.02019163
61SGK4941.02019163
62TAF10.99287153
63GRK50.97453516
64TAOK30.97263288
65CSNK1G10.97046031
66EPHA30.96463109
67CAMKK10.91833905
68CSNK1G20.90137616
69STK390.88368380
70TYRO30.88358298
71VRK10.87309125
72PASK0.87305772
73DYRK1A0.84892455
74DAPK10.84885813
75SGK20.84642041
76CDK140.83618739
77CDK180.82214344
78MAP2K60.81595110
79DYRK20.81027390
80CDK150.80483961
81IRAK10.78240129
82PLK30.77397397
83FLT30.76630340
84ROCK20.76312564
85BMPR1B0.74912276
86WNK30.74908995
87NLK0.72088967
88PIK3CA0.71679204
89DYRK30.69625312
90YES10.69133362
91CAMKK20.68337427
92FGR0.67899804
93STK30.67785897
94CDK11A0.67661557
95PKN10.67179346
96ERBB40.66558308
97CAMK10.66294330
98RAF10.66250452
99OXSR10.65630338
100CAMK2G0.64682979
101RET0.63863441
102ERBB30.63702718
103PRKCH0.63107864
104PRKCI0.62527091
105PRKCZ0.61386318
106TNK20.59525978
107MAP2K10.59430965
108MAP3K60.59287791
109ADRBK10.59033284
110MAPK150.58406399
111SGK10.58327687
112EIF2AK30.57832230
113TIE10.56156007
114MUSK0.55408455
115MAP3K70.55048119
116ARAF0.53607565
117TGFBR10.52154838
118PRKCB0.51125959
119MAPKAPK50.50771421
120CAMK40.47786563
121LATS20.47686729
122NME10.46792941
123WNK40.44004116
124RPS6KA30.43369014
125STK110.43310467
126BMPR20.43236328
127CSNK1A10.42575404
128ROCK10.42558681
129SGK30.42463626
130PRKACA0.42159195
131PTK2B0.40599133
132HIPK20.40474818
133CAMK1G0.40071680
134CSNK1G30.39731479
135MARK20.38498245
136MAPK100.38385931
137PRKG10.38341611
138CSNK1A1L0.38301908
139RPS6KA50.38178811
140BCKDK0.36913027
141FYN0.36254243
142PRKCA0.35675764
143PRKCQ0.34795516
144PLK40.33480220
145EIF2AK10.32932798
146MKNK10.31560669
147CSNK1D0.29285348
148TSSK60.28788079
149EPHB20.28225415
150LMTK20.28150572
151TXK0.26629268

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.74578219
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.57953957
3Synaptic vesicle cycle_Homo sapiens_hsa047212.90433255
4GABAergic synapse_Homo sapiens_hsa047272.87652800
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79107410
6Morphine addiction_Homo sapiens_hsa050322.61275026
7Protein export_Homo sapiens_hsa030602.57281276
8Glutamatergic synapse_Homo sapiens_hsa047242.55687864
9Circadian entrainment_Homo sapiens_hsa047132.45641778
10Olfactory transduction_Homo sapiens_hsa047402.39202173
11Linoleic acid metabolism_Homo sapiens_hsa005912.38147430
12Long-term potentiation_Homo sapiens_hsa047202.25408969
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17866310
14Selenocompound metabolism_Homo sapiens_hsa004502.16427803
15Dopaminergic synapse_Homo sapiens_hsa047282.15765053
16Caffeine metabolism_Homo sapiens_hsa002322.13452033
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12532392
18Amphetamine addiction_Homo sapiens_hsa050312.11164798
19Salivary secretion_Homo sapiens_hsa049702.05333178
20Renin secretion_Homo sapiens_hsa049242.04893756
21Taste transduction_Homo sapiens_hsa047421.98482958
22Insulin secretion_Homo sapiens_hsa049111.96808283
23Serotonergic synapse_Homo sapiens_hsa047261.93140684
24Ether lipid metabolism_Homo sapiens_hsa005651.87019192
25Propanoate metabolism_Homo sapiens_hsa006401.81345365
26Cholinergic synapse_Homo sapiens_hsa047251.78452906
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75385557
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73934025
29Tryptophan metabolism_Homo sapiens_hsa003801.70126839
30Nitrogen metabolism_Homo sapiens_hsa009101.67738325
31Axon guidance_Homo sapiens_hsa043601.66028463
32Cocaine addiction_Homo sapiens_hsa050301.64272444
33Phototransduction_Homo sapiens_hsa047441.63971182
34Gap junction_Homo sapiens_hsa045401.62785442
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61016445
36Gastric acid secretion_Homo sapiens_hsa049711.58999369
37Collecting duct acid secretion_Homo sapiens_hsa049661.56593434
38Homologous recombination_Homo sapiens_hsa034401.55739998
39Basal transcription factors_Homo sapiens_hsa030221.53732999
40Oxytocin signaling pathway_Homo sapiens_hsa049211.53297643
41Long-term depression_Homo sapiens_hsa047301.51246847
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46658276
43Calcium signaling pathway_Homo sapiens_hsa040201.46643713
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45267036
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45087216
46Peroxisome_Homo sapiens_hsa041461.30766506
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26424598
48Fanconi anemia pathway_Homo sapiens_hsa034601.25589030
49GnRH signaling pathway_Homo sapiens_hsa049121.25218007
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24532632
51cAMP signaling pathway_Homo sapiens_hsa040241.21599072
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.19316143
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19166647
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18845520
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15749540
56Huntingtons disease_Homo sapiens_hsa050161.13945092
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10434586
58Vibrio cholerae infection_Homo sapiens_hsa051101.10285999
59Cardiac muscle contraction_Homo sapiens_hsa042601.09752342
60Chemical carcinogenesis_Homo sapiens_hsa052041.08271288
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07628404
62beta-Alanine metabolism_Homo sapiens_hsa004101.07125447
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04762015
64Melanogenesis_Homo sapiens_hsa049161.03549664
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01731501
66RNA degradation_Homo sapiens_hsa030181.01438087
67ABC transporters_Homo sapiens_hsa020101.00090600
68Sulfur metabolism_Homo sapiens_hsa009200.99441736
69Arachidonic acid metabolism_Homo sapiens_hsa005900.97746704
70ErbB signaling pathway_Homo sapiens_hsa040120.96440564
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95666976
72Estrogen signaling pathway_Homo sapiens_hsa049150.94574777
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92065388
74RNA polymerase_Homo sapiens_hsa030200.90052572
75Glioma_Homo sapiens_hsa052140.89513065
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89430126
77Regulation of autophagy_Homo sapiens_hsa041400.88401490
78Alzheimers disease_Homo sapiens_hsa050100.88226356
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87861656
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87191328
81Folate biosynthesis_Homo sapiens_hsa007900.85930819
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85068286
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84937886
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.84148789
85Retinol metabolism_Homo sapiens_hsa008300.82815509
86Ovarian steroidogenesis_Homo sapiens_hsa049130.82610588
87Type II diabetes mellitus_Homo sapiens_hsa049300.82576802
88Dilated cardiomyopathy_Homo sapiens_hsa054140.80649261
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.79786542
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78650560
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77983772
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72864967
93Basal cell carcinoma_Homo sapiens_hsa052170.70236640
94Oxidative phosphorylation_Homo sapiens_hsa001900.69991735
95Pancreatic secretion_Homo sapiens_hsa049720.68472436
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.68024845
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67411306
98Choline metabolism in cancer_Homo sapiens_hsa052310.65393460
99MAPK signaling pathway_Homo sapiens_hsa040100.64199300
100Metabolic pathways_Homo sapiens_hsa011000.64044043
101One carbon pool by folate_Homo sapiens_hsa006700.63891860
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.61148485
103Renal cell carcinoma_Homo sapiens_hsa052110.60055046
104Histidine metabolism_Homo sapiens_hsa003400.59813850
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59191168
106Dorso-ventral axis formation_Homo sapiens_hsa043200.58070776
107Glucagon signaling pathway_Homo sapiens_hsa049220.56380688
108Ras signaling pathway_Homo sapiens_hsa040140.56299197
109Thyroid hormone synthesis_Homo sapiens_hsa049180.56278988
110Glycerolipid metabolism_Homo sapiens_hsa005610.54580732
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54572636
112Fat digestion and absorption_Homo sapiens_hsa049750.54292647
113Arginine and proline metabolism_Homo sapiens_hsa003300.53355268
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52942246
115Oocyte meiosis_Homo sapiens_hsa041140.52924188
116Alcoholism_Homo sapiens_hsa050340.52906637
117Purine metabolism_Homo sapiens_hsa002300.52314062
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51847005
119Wnt signaling pathway_Homo sapiens_hsa043100.51518743
120Parkinsons disease_Homo sapiens_hsa050120.51333572
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51305053
122Glutathione metabolism_Homo sapiens_hsa004800.50142471
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49493875
124Sphingolipid metabolism_Homo sapiens_hsa006000.49195399
125Rap1 signaling pathway_Homo sapiens_hsa040150.49118080
126Fatty acid degradation_Homo sapiens_hsa000710.48771775
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46186315
128Proteasome_Homo sapiens_hsa030500.45834018
129Fatty acid elongation_Homo sapiens_hsa000620.44978907
130Butanoate metabolism_Homo sapiens_hsa006500.42554888
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41921349
132Prion diseases_Homo sapiens_hsa050200.41317743
133Bile secretion_Homo sapiens_hsa049760.41135593
134Endometrial cancer_Homo sapiens_hsa052130.40743362
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39584284
136Circadian rhythm_Homo sapiens_hsa047100.39283499
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39036319
138VEGF signaling pathway_Homo sapiens_hsa043700.38851368
139Vitamin digestion and absorption_Homo sapiens_hsa049770.38098661
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37826761
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36804014
142mTOR signaling pathway_Homo sapiens_hsa041500.36544696
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34908799
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32926894
145Mineral absorption_Homo sapiens_hsa049780.32892835
146Melanoma_Homo sapiens_hsa052180.32542621
147Inositol phosphate metabolism_Homo sapiens_hsa005620.32138744
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.31641611
149Insulin signaling pathway_Homo sapiens_hsa049100.31333067
150Steroid biosynthesis_Homo sapiens_hsa001000.30933612
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.30696373
152African trypanosomiasis_Homo sapiens_hsa051430.30448183
153Fatty acid metabolism_Homo sapiens_hsa012120.30336173
154Endocytosis_Homo sapiens_hsa041440.29054053
155Hedgehog signaling pathway_Homo sapiens_hsa043400.28604513
156Colorectal cancer_Homo sapiens_hsa052100.28421608

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