PCDHB12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.18443645
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42552785
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.26814930
4neuronal action potential propagation (GO:0019227)5.26333214
5vocalization behavior (GO:0071625)5.25690032
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.24838497
7neuron cell-cell adhesion (GO:0007158)5.15019832
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.04473999
9protein localization to synapse (GO:0035418)4.98617087
10glutamate secretion (GO:0014047)4.95203090
11regulation of glutamate receptor signaling pathway (GO:1900449)4.93470239
12pyrimidine nucleobase catabolic process (GO:0006208)4.75444627
13regulation of synaptic vesicle exocytosis (GO:2000300)4.62612204
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.40384654
15neuron-neuron synaptic transmission (GO:0007270)4.34010249
16presynaptic membrane assembly (GO:0097105)4.33889305
17glutamate receptor signaling pathway (GO:0007215)4.29673816
18synaptic vesicle maturation (GO:0016188)4.27364116
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26189809
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.24900576
21neurotransmitter secretion (GO:0007269)4.22355810
22gamma-aminobutyric acid transport (GO:0015812)4.16376334
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.07612051
24calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.06557359
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.03920674
26synaptic transmission, glutamatergic (GO:0035249)4.03539405
27positive regulation of synapse maturation (GO:0090129)4.01904776
28regulation of synaptic vesicle transport (GO:1902803)4.00033661
29neurotransmitter-gated ion channel clustering (GO:0072578)3.94555024
30embryonic retina morphogenesis in camera-type eye (GO:0060059)3.91558715
31nucleobase catabolic process (GO:0046113)3.85479521
32presynaptic membrane organization (GO:0097090)3.84499906
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84168213
34neuron recognition (GO:0008038)3.83429606
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83079117
36locomotory exploration behavior (GO:0035641)3.80511720
37cerebellar granule cell differentiation (GO:0021707)3.76316099
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75504965
39regulation of neuronal synaptic plasticity (GO:0048168)3.73378487
40long-term synaptic potentiation (GO:0060291)3.73142153
41behavioral response to cocaine (GO:0048148)3.73011262
42regulation of postsynaptic membrane potential (GO:0060078)3.67972353
43exploration behavior (GO:0035640)3.64025414
44response to histamine (GO:0034776)3.55815736
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53014711
46ATP hydrolysis coupled proton transport (GO:0015991)3.51290457
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.51290457
48positive regulation of membrane potential (GO:0045838)3.50066210
49regulation of vesicle fusion (GO:0031338)3.47086757
50cellular potassium ion homeostasis (GO:0030007)3.46276023
51axonal fasciculation (GO:0007413)3.42387722
52layer formation in cerebral cortex (GO:0021819)3.40949750
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.40049699
54neurotransmitter transport (GO:0006836)3.39970965
55postsynaptic membrane organization (GO:0001941)3.39502316
56long-term memory (GO:0007616)3.39422184
57cell migration in hindbrain (GO:0021535)3.38853005
58cerebellar Purkinje cell differentiation (GO:0021702)3.36178842
59startle response (GO:0001964)3.35870870
60regulation of synaptic plasticity (GO:0048167)3.35681553
61synaptic vesicle endocytosis (GO:0048488)3.35366612
62transferrin transport (GO:0033572)3.34542886
63ganglion development (GO:0061548)3.33670708
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30891390
65detection of calcium ion (GO:0005513)3.30762106
66positive regulation of amino acid transport (GO:0051957)3.28669794
67regulation of neurotransmitter secretion (GO:0046928)3.25733736
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22095730
69regulation of dendritic spine morphogenesis (GO:0061001)3.20020966
70synaptic transmission, dopaminergic (GO:0001963)3.18915989
71regulation of neurotransmitter levels (GO:0001505)3.17659788
72* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.16933408
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15778688
74cerebral cortex radially oriented cell migration (GO:0021799)3.15215549
75ferric iron transport (GO:0015682)3.14553677
76trivalent inorganic cation transport (GO:0072512)3.14553677
77membrane depolarization (GO:0051899)3.14155843
78regulation of synapse maturation (GO:0090128)3.12312715
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11384742
80behavioral fear response (GO:0001662)3.07378061
81behavioral defense response (GO:0002209)3.07378061
82regulation of neurotransmitter transport (GO:0051588)3.06786390
83membrane hyperpolarization (GO:0060081)3.05098531
84dendritic spine morphogenesis (GO:0060997)3.03907974
85urinary tract smooth muscle contraction (GO:0014848)3.02282962
86positive regulation of synapse assembly (GO:0051965)3.01428012
87synaptic vesicle transport (GO:0048489)2.99701215
88establishment of synaptic vesicle localization (GO:0097480)2.99701215
89synaptic transmission (GO:0007268)2.99600743
90somite rostral/caudal axis specification (GO:0032525)2.98895910
91fear response (GO:0042596)2.98436023
92transmission of nerve impulse (GO:0019226)2.95798478
93mating behavior (GO:0007617)2.94115166
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.92496215
95regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.92496215
96central nervous system projection neuron axonogenesis (GO:0021952)2.92409119
97synapse assembly (GO:0007416)2.92321839
98regulation of voltage-gated calcium channel activity (GO:1901385)2.91524456
99proline transport (GO:0015824)2.91458055
100regulation of development, heterochronic (GO:0040034)2.90562823
101regulation of synapse structural plasticity (GO:0051823)2.88978483
102regulation of dendritic spine development (GO:0060998)2.88790844
103limb bud formation (GO:0060174)2.88055778
104axon extension involved in axon guidance (GO:0048846)2.87883626
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.87883626
106membrane depolarization during action potential (GO:0086010)2.87524560
107positive regulation of synaptic transmission (GO:0050806)2.86593971
108glycosphingolipid biosynthetic process (GO:0006688)2.86578230
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85467648
110cochlea development (GO:0090102)2.84660549
111learning (GO:0007612)2.84377264
112regulation of synaptic transmission (GO:0050804)2.84217263
113positive regulation of neurotransmitter transport (GO:0051590)2.83756364
114dendrite morphogenesis (GO:0048813)2.82556613
115cytoplasmic mRNA processing body assembly (GO:0033962)2.82322370
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80319025
117synapse organization (GO:0050808)2.80035212
118long term synaptic depression (GO:0060292)2.79787230
119positive regulation of mitochondrial fission (GO:0090141)2.77858645
120innervation (GO:0060384)2.77603392
121cerebral cortex cell migration (GO:0021795)2.77030012
122establishment of nucleus localization (GO:0040023)2.73585742
123central nervous system neuron axonogenesis (GO:0021955)2.68644695
124regulation of axon guidance (GO:1902667)2.67476361
125head development (GO:0060322)2.62437630
126regulation of feeding behavior (GO:0060259)2.62239970
127negative chemotaxis (GO:0050919)2.62015735
128* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.59700668
129* cell-cell adhesion (GO:0098609)2.59046364
130establishment of mitochondrion localization (GO:0051654)2.59044204
131olfactory bulb development (GO:0021772)2.56394970
132spinal cord development (GO:0021510)2.55357071
133positive regulation of gastrulation (GO:2000543)2.51901988
134limb development (GO:0060173)2.50409372
135appendage development (GO:0048736)2.50409372
136negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48634616
137retinal ganglion cell axon guidance (GO:0031290)2.46195636
138nonmotile primary cilium assembly (GO:0035058)2.45426481
139RNA localization (GO:0006403)2.44585830
140behavioral response to ethanol (GO:0048149)2.43485324
141negative regulation of axon guidance (GO:1902668)2.39279412
142regulation of axon extension involved in axon guidance (GO:0048841)2.36446405
143ectodermal placode formation (GO:0060788)2.35356967
144hippocampus development (GO:0021766)2.34630338
145auditory behavior (GO:0031223)2.33396666
146regulation of timing of cell differentiation (GO:0048505)2.33353775
147axon extension (GO:0048675)2.32062161
148inner ear receptor cell development (GO:0060119)2.30465795
149positive regulation of dendritic spine morphogenesis (GO:0061003)2.30339129
150ephrin receptor signaling pathway (GO:0048013)2.29300899
151axonogenesis (GO:0007409)2.29054226
152behavioral response to nicotine (GO:0035095)2.27512960
153sympathetic nervous system development (GO:0048485)2.26951315
154glomerulus development (GO:0032835)2.25093787
155righting reflex (GO:0060013)2.24937475
156response to pheromone (GO:0019236)2.24703534
157membrane assembly (GO:0071709)2.23482241
158apical protein localization (GO:0045176)2.23400522
159neuronal ion channel clustering (GO:0045161)2.22051737
160regulation of chemokine-mediated signaling pathway (GO:0070099)2.21029743
161dendrite development (GO:0016358)2.20580791
162neuromuscular synaptic transmission (GO:0007274)2.18214826
163neuron migration (GO:0001764)2.16782789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47461727
2GBX2_23144817_ChIP-Seq_PC3_Human4.49615100
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20952472
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16137915
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03730943
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69937035
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69318412
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69318412
9TAF15_26573619_Chip-Seq_HEK293_Human2.61872760
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58592931
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53442558
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.51842969
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47036151
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.45662609
15REST_21632747_ChIP-Seq_MESCs_Mouse2.45341581
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40193566
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34781639
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29514285
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19626967
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.14137438
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.10844958
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08015920
23DROSHA_22980978_ChIP-Seq_HELA_Human2.06280955
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06136223
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04463038
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.03648581
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00309239
28AR_21572438_ChIP-Seq_LNCaP_Human2.00037793
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.94736448
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92504419
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84597259
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83439456
33SMAD4_21799915_ChIP-Seq_A2780_Human1.83147482
34P300_19829295_ChIP-Seq_ESCs_Human1.79216113
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76006083
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75816679
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74659581
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74631627
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74519001
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71325069
41VDR_22108803_ChIP-Seq_LS180_Human1.69613061
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67205451
43FUS_26573619_Chip-Seq_HEK293_Human1.64074317
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62734457
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.58354586
46EWS_26573619_Chip-Seq_HEK293_Human1.58308169
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57768520
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.54781299
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53059550
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48975629
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46018839
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.44660687
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43318024
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43311167
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42736310
56AR_25329375_ChIP-Seq_VCAP_Human1.42497793
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.40487974
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.39613027
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38865629
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34928634
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31755430
62ZNF274_21170338_ChIP-Seq_K562_Hela1.30502761
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29901456
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28732030
65STAT3_23295773_ChIP-Seq_U87_Human1.27049538
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26850015
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.26218134
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24809295
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.21974529
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21152303
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19633257
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19594523
73ER_23166858_ChIP-Seq_MCF-7_Human1.19153154
74SOX9_26525672_Chip-Seq_HEART_Mouse1.18911371
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18773189
76RNF2_27304074_Chip-Seq_NSC_Mouse1.18129821
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.17253132
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16158969
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16158969
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15574138
81JUN_21703547_ChIP-Seq_K562_Human1.15559639
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15287761
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13583998
84TCF4_23295773_ChIP-Seq_U87_Human1.13026005
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12334407
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.10762505
87BCAT_22108803_ChIP-Seq_LS180_Human1.10531058
88RUNX2_22187159_ChIP-Seq_PCA_Human1.08679614
89AHR_22903824_ChIP-Seq_MCF-7_Human1.08401461
90AR_19668381_ChIP-Seq_PC3_Human1.08382229
91IGF1R_20145208_ChIP-Seq_DFB_Human1.07951767
92TP53_16413492_ChIP-PET_HCT116_Human1.07451837
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05780858
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.05774584
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05468583
96TP53_18474530_ChIP-ChIP_U2OS_Human1.05437926
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04660484
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04115267
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.03700746
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01401731
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00971183
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00354594
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00354594
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00225579
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00080075
106P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99936588
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99929096
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.99530929
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99348756
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98588921
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98236460
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97619421
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96762744
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96285885
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.94712231
116KDM2B_26808549_Chip-Seq_REH_Human0.92960498
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92770212
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90445014
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.88406060
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.86959068
121CBP_20019798_ChIP-Seq_JUKART_Human0.86785372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.61888886
2MP0003880_abnormal_central_pattern5.06356920
3MP0003635_abnormal_synaptic_transmissio4.04865969
4MP0009745_abnormal_behavioral_response3.44231122
5MP0009046_muscle_twitch3.40961634
6MP0004270_analgesia3.35566462
7MP0002064_seizures3.30676652
8MP0002063_abnormal_learning/memory/cond3.23149977
9MP0001968_abnormal_touch/_nociception2.99536594
10MP0002572_abnormal_emotion/affect_behav2.96537108
11MP0002272_abnormal_nervous_system2.73835489
12MP0002736_abnormal_nociception_after2.61687733
13MP0002734_abnormal_mechanical_nocicepti2.57578314
14MP0001486_abnormal_startle_reflex2.39386174
15MP0001440_abnormal_grooming_behavior2.38536578
16MP0001501_abnormal_sleep_pattern2.34964985
17MP0003329_amyloid_beta_deposits2.19647845
18MP0001984_abnormal_olfaction2.19631466
19MP0003890_abnormal_embryonic-extraembry2.14858206
20MP0002735_abnormal_chemical_nociception2.14009612
21MP0009780_abnormal_chondrocyte_physiolo2.12975852
22MP0002067_abnormal_sensory_capabilities2.12969357
23MP0002837_dystrophic_cardiac_calcinosis1.91456344
24MP0005248_abnormal_Harderian_gland1.89702055
25MP0001529_abnormal_vocalization1.88934071
26MP0002822_catalepsy1.85765125
27MP0003787_abnormal_imprinting1.85162923
28MP0005423_abnormal_somatic_nervous1.83338154
29MP0002184_abnormal_innervation1.83101219
30MP0001970_abnormal_pain_threshold1.81068593
31MP0004924_abnormal_behavior1.79331327
32MP0005386_behavior/neurological_phenoty1.79331327
33MP0000778_abnormal_nervous_system1.75197193
34MP0002733_abnormal_thermal_nociception1.74028167
35MP0001905_abnormal_dopamine_level1.69128130
36MP0005187_abnormal_penis_morphology1.68732441
37MP0008569_lethality_at_weaning1.67289340
38MP0002557_abnormal_social/conspecific_i1.64057109
39MP0003879_abnormal_hair_cell1.62392858
40MP0006276_abnormal_autonomic_nervous1.61457099
41MP0005646_abnormal_pituitary_gland1.57330475
42MP0002653_abnormal_ependyma_morphology1.55749944
43MP0003283_abnormal_digestive_organ1.53101740
44MP0003122_maternal_imprinting1.52921562
45MP0001299_abnormal_eye_distance/1.52712119
46MP0004811_abnormal_neuron_physiology1.46482623
47MP0002751_abnormal_autonomic_nervous1.45494299
48MP0001188_hyperpigmentation1.44536750
49MP0004233_abnormal_muscle_weight1.43778468
50MP0002102_abnormal_ear_morphology1.43606358
51MP0000955_abnormal_spinal_cord1.43487551
52MP0002066_abnormal_motor_capabilities/c1.42233593
53MP0003121_genomic_imprinting1.41209899
54MP0000569_abnormal_digit_pigmentation1.39668470
55MP0005367_renal/urinary_system_phenotyp1.37859897
56MP0000516_abnormal_urinary_system1.37859897
57MP0005551_abnormal_eye_electrophysiolog1.34776584
58MP0002882_abnormal_neuron_morphology1.34666280
59MP0000751_myopathy1.33277817
60MP0010386_abnormal_urinary_bladder1.28604334
61MP0002909_abnormal_adrenal_gland1.27043792
62MP0003119_abnormal_digestive_system1.24659618
63MP0004142_abnormal_muscle_tone1.23986308
64MP0000013_abnormal_adipose_tissue1.21985918
65MP0003942_abnormal_urinary_system1.21960268
66MP0001502_abnormal_circadian_rhythm1.20555819
67MP0005171_absent_coat_pigmentation1.19920786
68MP0000534_abnormal_ureter_morphology1.18019012
69MP0003633_abnormal_nervous_system1.16719222
70MP0004858_abnormal_nervous_system1.14611759
71MP0004145_abnormal_muscle_electrophysio1.13650958
72MP0000049_abnormal_middle_ear1.13552400
73MP0002876_abnormal_thyroid_physiology1.12516560
74MP0003861_abnormal_nervous_system1.10828947
75MP0003937_abnormal_limbs/digits/tail_de1.09893338
76MP0004215_abnormal_myocardial_fiber1.09206004
77MP0003631_nervous_system_phenotype1.08048774
78MP0000604_amyloidosis1.02623324
79MP0004885_abnormal_endolymph1.01639266
80MP0003385_abnormal_body_wall1.01458113
81MP0003755_abnormal_palate_morphology1.01268521
82MP0002152_abnormal_brain_morphology1.00937970
83MP0008872_abnormal_physiological_respon1.00213616
84MP0004085_abnormal_heartbeat0.97596303
85MP0000647_abnormal_sebaceous_gland0.97330197
86MP0005257_abnormal_intraocular_pressure0.96829054
87MP0002229_neurodegeneration0.96459271
88MP0005253_abnormal_eye_physiology0.95489706
89MP0004036_abnormal_muscle_relaxation0.94824360
90MP0004134_abnormal_chest_morphology0.92641948
91MP0004484_altered_response_of0.91926226
92MP0002233_abnormal_nose_morphology0.91662860
93MP0002938_white_spotting0.91603359
94MP0002090_abnormal_vision0.90884728
95MP0004742_abnormal_vestibular_system0.89931452
96MP0003632_abnormal_nervous_system0.87333155
97MP0001963_abnormal_hearing_physiology0.87049123
98MP0001286_abnormal_eye_development0.86242705
99MP0008874_decreased_physiological_sensi0.85148984
100MP0003123_paternal_imprinting0.84700903
101MP0002069_abnormal_eating/drinking_beha0.84593879
102MP0008789_abnormal_olfactory_epithelium0.84468598
103MP0001177_atelectasis0.83471676
104MP0000462_abnormal_digestive_system0.82057366
105MP0003634_abnormal_glial_cell0.81940729
106MP0005535_abnormal_body_temperature0.81573085
107MP0002752_abnormal_somatic_nervous0.80540989
108MP0002697_abnormal_eye_size0.80518268
109MP0005645_abnormal_hypothalamus_physiol0.80295947
110MP0005195_abnormal_posterior_eye0.79644534
111MP0000427_abnormal_hair_cycle0.79540671
112MP0001293_anophthalmia0.79490322
113MP0003935_abnormal_craniofacial_develop0.79205283
114MP0003115_abnormal_respiratory_system0.77245018
115MP0000920_abnormal_myelination0.73328029
116MP0001485_abnormal_pinna_reflex0.72289138
117MP0001664_abnormal_digestion0.72194975
118MP0000631_abnormal_neuroendocrine_gland0.70030681
119MP0005499_abnormal_olfactory_system0.69364285
120MP0005394_taste/olfaction_phenotype0.69364285
121MP0005623_abnormal_meninges_morphology0.65952536
122MP0001943_abnormal_respiration0.62951827
123MP0003137_abnormal_impulse_conducting0.62879440
124MP0003646_muscle_fatigue0.61772433
125MP0005620_abnormal_muscle_contractility0.55896820
126MP0004043_abnormal_pH_regulation0.55569444
127MP0008877_abnormal_DNA_methylation0.54916649
128MP0006072_abnormal_retinal_apoptosis0.54847166
129MP0003075_altered_response_to0.53968855
130MP0002638_abnormal_pupillary_reflex0.53889295
131MP0003690_abnormal_glial_cell0.52711145
132MP0005409_darkened_coat_color0.51793546
133MP0000026_abnormal_inner_ear0.51109844
134MP0002082_postnatal_lethality0.49760416
135MP0010770_preweaning_lethality0.49760416
136MP0010769_abnormal_survival0.49427958

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.70637453
2Epileptic encephalopathy (HP:0200134)6.06161129
3Atonic seizures (HP:0010819)5.90804531
4Hyperventilation (HP:0002883)5.64091546
5Focal seizures (HP:0007359)5.54800922
6Absence seizures (HP:0002121)4.95589223
7Febrile seizures (HP:0002373)4.84030925
8Visual hallucinations (HP:0002367)4.83713634
9Myokymia (HP:0002411)4.80656393
10Dialeptic seizures (HP:0011146)4.49869257
11Generalized tonic-clonic seizures (HP:0002069)3.91182274
12Broad-based gait (HP:0002136)3.87255830
13Progressive cerebellar ataxia (HP:0002073)3.79183407
14Poor eye contact (HP:0000817)3.41311079
15Epileptiform EEG discharges (HP:0011182)3.39311367
16Gaze-evoked nystagmus (HP:0000640)3.28265284
17Amblyopia (HP:0000646)3.17639634
18Impaired social interactions (HP:0000735)3.09709799
19Abnormal social behavior (HP:0012433)3.09709799
20EEG with generalized epileptiform discharges (HP:0011198)3.09451055
21Pheochromocytoma (HP:0002666)3.03185702
22Absent speech (HP:0001344)2.82256571
23Action tremor (HP:0002345)2.81664735
24Drooling (HP:0002307)2.80681476
25Excessive salivation (HP:0003781)2.80681476
26Dysdiadochokinesis (HP:0002075)2.80274526
27Hypsarrhythmia (HP:0002521)2.76884539
28Blue irides (HP:0000635)2.76844874
29Neuroendocrine neoplasm (HP:0100634)2.76743607
30Inability to walk (HP:0002540)2.68856836
31Truncal ataxia (HP:0002078)2.68647436
32Cerebral inclusion bodies (HP:0100314)2.68535051
33Abnormal eating behavior (HP:0100738)2.67763692
34Dysmetria (HP:0001310)2.63591389
35Impaired vibration sensation in the lower limbs (HP:0002166)2.59172099
36Anxiety (HP:0000739)2.51897325
37Generalized myoclonic seizures (HP:0002123)2.47090984
38Depression (HP:0000716)2.46539959
39Lissencephaly (HP:0001339)2.43702647
40Scanning speech (HP:0002168)2.43033030
41Insidious onset (HP:0003587)2.41011581
42Termporal pattern (HP:0011008)2.41011581
43Polyphagia (HP:0002591)2.36473932
44Protruding tongue (HP:0010808)2.34790990
45Hepatoblastoma (HP:0002884)2.31987076
46Abnormality of binocular vision (HP:0011514)2.28123423
47Diplopia (HP:0000651)2.28123423
48Gait imbalance (HP:0002141)2.25919219
49Abnormal hair whorl (HP:0010721)2.25465566
50Supranuclear gaze palsy (HP:0000605)2.24552222
51Nephrogenic diabetes insipidus (HP:0009806)2.24387348
52Fair hair (HP:0002286)2.24195644
53Abnormality of the corticospinal tract (HP:0002492)2.23580778
54Absent eyebrow (HP:0002223)2.21662031
55Neurofibrillary tangles (HP:0002185)2.21557483
56Thickened helices (HP:0000391)2.21351207
57Urinary bladder sphincter dysfunction (HP:0002839)2.18595831
58Fetal akinesia sequence (HP:0001989)2.17694682
59Ankle clonus (HP:0011448)2.15677494
60Hyperthyroidism (HP:0000836)2.15676990
61Esotropia (HP:0000565)2.15635976
62Increased serum pyruvate (HP:0003542)2.15324039
63Abnormality of glycolysis (HP:0004366)2.15324039
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14821487
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.14821487
66Progressive inability to walk (HP:0002505)2.10392093
67Hemiparesis (HP:0001269)2.08963049
68Postural instability (HP:0002172)2.08816624
69Type II lissencephaly (HP:0007260)2.07423068
70Hemiplegia (HP:0002301)2.06171437
71Genital tract atresia (HP:0001827)2.06145435
72Status epilepticus (HP:0002133)2.05023330
73Stereotypic behavior (HP:0000733)2.04522614
74Acute necrotizing encephalopathy (HP:0006965)2.03346353
75Generalized hypopigmentation of hair (HP:0011358)2.03274861
76Impaired smooth pursuit (HP:0007772)2.02983335
77Neoplasm of the heart (HP:0100544)2.01322108
78Limb dystonia (HP:0002451)1.99808406
79Vaginal atresia (HP:0000148)1.99801244
80Dysmetric saccades (HP:0000641)1.98361810
81Genetic anticipation (HP:0003743)1.98156962
82Abnormal mitochondria in muscle tissue (HP:0008316)1.96441847
83Congenital primary aphakia (HP:0007707)1.96219649
84Pachygyria (HP:0001302)1.95694202
85Nephronophthisis (HP:0000090)1.95522277
86Clumsiness (HP:0002312)1.95277807
87Colon cancer (HP:0003003)1.94951054
88Bradykinesia (HP:0002067)1.94528273
89Exotropia (HP:0000577)1.92294992
90Hypoventilation (HP:0002791)1.91528856
91Abnormality of the lower motor neuron (HP:0002366)1.90484685
92Gait ataxia (HP:0002066)1.90109470
93Cerebellar dysplasia (HP:0007033)1.90073657
94Delusions (HP:0000746)1.90025358
95Poor suck (HP:0002033)1.89202948
96Narrow nasal bridge (HP:0000446)1.89008229
97Resting tremor (HP:0002322)1.88747694
98Abnormality of the labia minora (HP:0012880)1.88668491
99Short 4th metacarpal (HP:0010044)1.88310339
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88310339
101Rimmed vacuoles (HP:0003805)1.88099308
102Progressive macrocephaly (HP:0004481)1.87462160
103Abnormality of salivation (HP:0100755)1.87384969
104Torticollis (HP:0000473)1.86524957
105Intention tremor (HP:0002080)1.86297387
106Abnormality of macular pigmentation (HP:0008002)1.84269921
107Spastic gait (HP:0002064)1.84262333
108Mutism (HP:0002300)1.84002206
109Incomplete penetrance (HP:0003829)1.83117588
110Spastic tetraplegia (HP:0002510)1.83082727
111Medial flaring of the eyebrow (HP:0010747)1.82945734
112Failure to thrive in infancy (HP:0001531)1.82857402
113Tubulointerstitial nephritis (HP:0001970)1.82786499
114Abnormality of the astrocytes (HP:0100707)1.80406876
115Astrocytoma (HP:0009592)1.80406876
116Gastroesophageal reflux (HP:0002020)1.79800839
117Urinary urgency (HP:0000012)1.79038971
118Lower limb muscle weakness (HP:0007340)1.78953516
119Specific learning disability (HP:0001328)1.78624454
120Neoplasm of the peripheral nervous system (HP:0100007)1.77986075
121Impaired vibratory sensation (HP:0002495)1.77795424
122Focal dystonia (HP:0004373)1.77402083
123Tented upper lip vermilion (HP:0010804)1.76866712
124Shawl scrotum (HP:0000049)1.75919778
125Limb-girdle muscle atrophy (HP:0003797)1.73320072
126Cortical dysplasia (HP:0002539)1.72831506
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71173122
128Hypoplasia of the brainstem (HP:0002365)1.71173122
129Papilledema (HP:0001085)1.70580244
130Intestinal atresia (HP:0011100)1.70038265
131Cupped ear (HP:0000378)1.68328078
132Absent eyelashes (HP:0000561)1.68157512
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.67762840
134Micropenis (HP:0000054)1.66833182
135Prominent supraorbital ridges (HP:0000336)1.66439435
136Anterior segment dysgenesis (HP:0007700)1.66074936
137Fibular aplasia (HP:0002990)1.66026060
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65624741
139Optic nerve hypoplasia (HP:0000609)1.65386195
140Retinal dysplasia (HP:0007973)1.64141417
141Abnormality of the metopic suture (HP:0005556)1.63779269
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.63254902
143Glioma (HP:0009733)1.62495189
144Chronic hepatic failure (HP:0100626)1.62258542
145Cutaneous finger syndactyly (HP:0010554)1.62054213
146Abnormality of the renal medulla (HP:0100957)1.61452468
147Pendular nystagmus (HP:0012043)1.59435768
148Pancreatic fibrosis (HP:0100732)1.57373503
149Shoulder girdle muscle weakness (HP:0003547)1.57036409
150Pancreatic cysts (HP:0001737)1.56894596
151Amyotrophic lateral sclerosis (HP:0007354)1.56391144
152Morphological abnormality of the pyramidal tract (HP:0002062)1.55373183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.23871075
2CASK4.03595791
3NTRK33.65097003
4MAP3K43.36448614
5MAP3K93.17970781
6MAP3K123.11978871
7MAP2K73.02505798
8MINK12.33319480
9MAP3K62.28286260
10PLK22.26915074
11MAP2K42.16579331
12DAPK22.13743317
13TRIM282.04735772
14MARK11.97996156
15EPHA31.95487047
16RIPK41.92694663
17BRD41.92012458
18CDK191.87951974
19ARAF1.86188277
20FRK1.81303704
21PAK61.76692601
22PRPF4B1.70502107
23DAPK11.70396883
24TNIK1.70077907
25GRK51.64838608
26STK38L1.62971904
27KSR11.57523191
28NTRK21.54349632
29PNCK1.51255177
30NTRK11.50639684
31KSR21.48363031
32DYRK21.46226788
33CCNB11.43127423
34PINK11.40785785
35EPHB21.40536856
36OXSR11.39396788
37LATS11.38423355
38PTK2B1.33023516
39MAP3K131.31824988
40CDK51.31220527
41PIM21.27700903
42AKT31.27064152
43MAPK131.25674860
44MAP4K21.22743398
45PRKCG1.21329292
46CAMKK21.20434247
47MKNK21.17937683
48SIK21.17441488
49CAMK2A1.15335260
50CAMK2B1.13447378
51SIK31.13040896
52CSNK1G11.11307239
53CSNK1A1L1.04992509
54CSNK1G31.04242975
55FES1.03507367
56BCR1.03403507
57MUSK1.02777594
58BMPR21.01165213
59FGR1.00294176
60SRPK10.97793373
61NME10.96337241
62DYRK1B0.95417471
63CAMKK10.94401531
64SGK4940.92641128
65SGK2230.92641128
66RPS6KA40.91315310
67PRKCE0.91173125
68CDK180.89924529
69CDK30.89637998
70DYRK30.89085045
71LIMK10.89063360
72CDK140.85021616
73CDK150.82362557
74YES10.81912201
75FER0.75950599
76PHKG20.74784737
77PHKG10.74784737
78CAMK2D0.74378716
79PRKD30.73563022
80CDK11A0.71683066
81CSNK1G20.71566309
82SGK20.70846195
83GRK70.70601530
84UHMK10.70376369
85MAPK120.70276863
86MAP3K50.69882769
87CAMK10.68333686
88DYRK1A0.67543046
89TIE10.66653983
90MET0.65966413
91BRAF0.65679599
92PDGFRA0.64803923
93MKNK10.64545002
94PAK30.64396102
95RAF10.63006655
96TSSK60.62957420
97PRKCH0.62831145
98INSRR0.62443927
99LMTK20.61260518
100ROCK20.60979053
101PDK40.60450073
102PDK30.60450073
103CAMK2G0.60065253
104STK390.57267376
105SGK10.56785865
106MAPK70.53772866
107STK110.53226569
108MAP3K20.51137713
109STK380.50237155
110PIK3CA0.49227440
111FGFR20.47994391
112MAP3K10.47640372
113PDPK10.47153805
114CAMK40.46318444
115ERBB20.45922434
116GRK60.45510478
117WNK30.44993276
118MAP2K10.44593017
119ROCK10.44360806
120ADRBK20.44043920
121TYRO30.43684536
122PRKAA10.43486584
123SGK30.43228269
124PKN10.42430158
125PASK0.42210670
126CAMK1D0.41876330
127RPS6KA20.41415708
128RET0.40153480
129ADRBK10.38540216
130PRKACA0.38261183
131FYN0.37592302
132ERBB30.37499161
133PRKCZ0.37392305
134GRK10.36424527
135ERBB40.36310826
136PDK10.35907549
137CAMK1G0.35696232
138LATS20.34606211
139DAPK30.34459416
140RPS6KA30.33383723
141MYLK0.33364931

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82897886
2Synaptic vesicle cycle_Homo sapiens_hsa047213.75563863
3Collecting duct acid secretion_Homo sapiens_hsa049662.97964058
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77769237
5GABAergic synapse_Homo sapiens_hsa047272.74141507
6Olfactory transduction_Homo sapiens_hsa047402.67455997
7Circadian entrainment_Homo sapiens_hsa047132.54516040
8Long-term potentiation_Homo sapiens_hsa047202.50827927
9Morphine addiction_Homo sapiens_hsa050322.45695454
10Glutamatergic synapse_Homo sapiens_hsa047242.30265437
11Amphetamine addiction_Homo sapiens_hsa050312.27580017
12Dopaminergic synapse_Homo sapiens_hsa047282.07094641
13Salivary secretion_Homo sapiens_hsa049702.00928661
14Taste transduction_Homo sapiens_hsa047421.87781264
15Vibrio cholerae infection_Homo sapiens_hsa051101.86329937
16Renin secretion_Homo sapiens_hsa049241.85556172
17Serotonergic synapse_Homo sapiens_hsa047261.77488440
18Insulin secretion_Homo sapiens_hsa049111.72461858
19Oxidative phosphorylation_Homo sapiens_hsa001901.71738809
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69735367
21Cholinergic synapse_Homo sapiens_hsa047251.63252269
22Long-term depression_Homo sapiens_hsa047301.59533271
23Gastric acid secretion_Homo sapiens_hsa049711.58053828
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57580625
25Calcium signaling pathway_Homo sapiens_hsa040201.55130001
26Oxytocin signaling pathway_Homo sapiens_hsa049211.53515064
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49560969
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41422767
29Cocaine addiction_Homo sapiens_hsa050301.39244333
30Cardiac muscle contraction_Homo sapiens_hsa042601.35633439
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35250127
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34348279
33Alzheimers disease_Homo sapiens_hsa050101.29782044
34Hippo signaling pathway_Homo sapiens_hsa043901.29070878
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24426504
36Hedgehog signaling pathway_Homo sapiens_hsa043401.22221401
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21744405
38GnRH signaling pathway_Homo sapiens_hsa049121.19150835
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15972399
40Gap junction_Homo sapiens_hsa045401.14747298
41Phototransduction_Homo sapiens_hsa047441.12424268
42Propanoate metabolism_Homo sapiens_hsa006401.11857398
43cAMP signaling pathway_Homo sapiens_hsa040241.10636811
44Parkinsons disease_Homo sapiens_hsa050121.09691239
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09013522
46Steroid biosynthesis_Homo sapiens_hsa001001.07340591
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04996060
48Basal cell carcinoma_Homo sapiens_hsa052171.03987609
49Axon guidance_Homo sapiens_hsa043601.03917053
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02894017
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00871242
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99722052
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.93832956
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93223798
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91462243
56Estrogen signaling pathway_Homo sapiens_hsa049150.90663388
57Melanoma_Homo sapiens_hsa052180.86720448
58Melanogenesis_Homo sapiens_hsa049160.85324886
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84673860
60Rheumatoid arthritis_Homo sapiens_hsa053230.84037167
61ErbB signaling pathway_Homo sapiens_hsa040120.83760412
62Tight junction_Homo sapiens_hsa045300.83188737
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.82563430
64beta-Alanine metabolism_Homo sapiens_hsa004100.80180915
65Glioma_Homo sapiens_hsa052140.79736366
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78233537
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77249684
68Type II diabetes mellitus_Homo sapiens_hsa049300.76956195
69Dilated cardiomyopathy_Homo sapiens_hsa054140.73833819
70Adherens junction_Homo sapiens_hsa045200.70083291
71Butanoate metabolism_Homo sapiens_hsa006500.66872988
72Huntingtons disease_Homo sapiens_hsa050160.65672216
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65260664
74Pancreatic secretion_Homo sapiens_hsa049720.64611757
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61291339
76Thyroid hormone synthesis_Homo sapiens_hsa049180.59910230
77MAPK signaling pathway_Homo sapiens_hsa040100.59791761
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59732649
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59636253
80Oocyte meiosis_Homo sapiens_hsa041140.59269450
81Fatty acid metabolism_Homo sapiens_hsa012120.59086894
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58876677
83Dorso-ventral axis formation_Homo sapiens_hsa043200.58539941
84Type I diabetes mellitus_Homo sapiens_hsa049400.57035580
85Basal transcription factors_Homo sapiens_hsa030220.54348410
86Glucagon signaling pathway_Homo sapiens_hsa049220.53568652
87Circadian rhythm_Homo sapiens_hsa047100.53131542
88Phagosome_Homo sapiens_hsa041450.52369210
89Ras signaling pathway_Homo sapiens_hsa040140.50982019
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50970935
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50881678
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49514858
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48891595
94Colorectal cancer_Homo sapiens_hsa052100.48505255
95Pyruvate metabolism_Homo sapiens_hsa006200.48306027
96Protein export_Homo sapiens_hsa030600.47907126
97Alcoholism_Homo sapiens_hsa050340.47650022
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47532919
99AMPK signaling pathway_Homo sapiens_hsa041520.47386394
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.46453828
101Choline metabolism in cancer_Homo sapiens_hsa052310.45583822
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45315500
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45268910
104ECM-receptor interaction_Homo sapiens_hsa045120.43518463
105Endometrial cancer_Homo sapiens_hsa052130.43444924
106Fatty acid biosynthesis_Homo sapiens_hsa000610.40921364
107Protein digestion and absorption_Homo sapiens_hsa049740.40608122
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40228438
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39815665
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39276049
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39141163
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38286837
113Selenocompound metabolism_Homo sapiens_hsa004500.35981305
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35923638
115African trypanosomiasis_Homo sapiens_hsa051430.35028584
116FoxO signaling pathway_Homo sapiens_hsa040680.34743433
117Regulation of autophagy_Homo sapiens_hsa041400.34361364
118RNA polymerase_Homo sapiens_hsa030200.34350640
119Prolactin signaling pathway_Homo sapiens_hsa049170.33966937
120Focal adhesion_Homo sapiens_hsa045100.33855694
121Rap1 signaling pathway_Homo sapiens_hsa040150.33435491
122Renal cell carcinoma_Homo sapiens_hsa052110.30690150
123Inositol phosphate metabolism_Homo sapiens_hsa005620.29822925
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29754949
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.29599384
126Wnt signaling pathway_Homo sapiens_hsa043100.29446612
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.29207395
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28588960
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25422515
130Bile secretion_Homo sapiens_hsa049760.25203918
131VEGF signaling pathway_Homo sapiens_hsa043700.22574374
132Prion diseases_Homo sapiens_hsa050200.22503356
133Fatty acid elongation_Homo sapiens_hsa000620.22290365
134Endocytosis_Homo sapiens_hsa041440.21610429

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