PCDHB14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.82478532
2neuron cell-cell adhesion (GO:0007158)4.70814431
3nucleobase catabolic process (GO:0046113)4.59501518
4presynaptic membrane assembly (GO:0097105)4.44994279
5behavioral response to nicotine (GO:0035095)4.15409986
6vocalization behavior (GO:0071625)4.03623137
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99972250
8ionotropic glutamate receptor signaling pathway (GO:0035235)3.99361342
9presynaptic membrane organization (GO:0097090)3.98614877
10negative regulation of synaptic transmission, GABAergic (GO:0032229)3.95853127
11postsynaptic membrane organization (GO:0001941)3.88790243
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87717244
13glutamate receptor signaling pathway (GO:0007215)3.83586112
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83358559
15neurotransmitter-gated ion channel clustering (GO:0072578)3.79394924
16cell migration in hindbrain (GO:0021535)3.74022696
17establishment of mitochondrion localization (GO:0051654)3.73887376
18glycosphingolipid biosynthetic process (GO:0006688)3.73318000
19startle response (GO:0001964)3.62926960
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52229561
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50843496
22regulation of glutamate receptor signaling pathway (GO:1900449)3.46696457
23protein localization to synapse (GO:0035418)3.46050651
24synaptic transmission, glutamatergic (GO:0035249)3.39910491
25transmission of nerve impulse (GO:0019226)3.38934747
26neuron-neuron synaptic transmission (GO:0007270)3.37695634
27synaptic vesicle maturation (GO:0016188)3.33591901
28regulation of action potential (GO:0098900)3.28752405
29L-amino acid import (GO:0043092)3.24092814
30righting reflex (GO:0060013)3.24011106
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.23882227
32cerebral cortex radially oriented cell migration (GO:0021799)3.23683462
33locomotory exploration behavior (GO:0035641)3.21620902
34auditory behavior (GO:0031223)3.19410068
35negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19080755
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18215647
37response to auditory stimulus (GO:0010996)3.17013460
38regulation of synaptic vesicle exocytosis (GO:2000300)3.16715341
39neuronal action potential propagation (GO:0019227)3.15366802
40positive regulation of action potential (GO:0045760)3.14434743
41neuron recognition (GO:0008038)3.13255904
42drinking behavior (GO:0042756)3.12228307
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.10367749
44axon extension (GO:0048675)3.08242902
45establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02971137
46mitochondrion transport along microtubule (GO:0047497)3.02971137
47dendritic spine morphogenesis (GO:0060997)3.02628179
48nonmotile primary cilium assembly (GO:0035058)3.00155335
49glycerophospholipid catabolic process (GO:0046475)2.99664954
50mechanosensory behavior (GO:0007638)2.97596419
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96321622
52dendrite morphogenesis (GO:0048813)2.95834043
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93535332
54positive regulation of synapse assembly (GO:0051965)2.88330535
55regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88018538
56regulation of synapse structural plasticity (GO:0051823)2.86573602
57tachykinin receptor signaling pathway (GO:0007217)2.86094100
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85458518
59* synapse organization (GO:0050808)2.84765008
60layer formation in cerebral cortex (GO:0021819)2.82661214
61long-term synaptic potentiation (GO:0060291)2.82636842
62lens morphogenesis in camera-type eye (GO:0002089)2.80894287
63regulation of postsynaptic membrane potential (GO:0060078)2.80817269
64central nervous system neuron axonogenesis (GO:0021955)2.80711673
65synaptic vesicle exocytosis (GO:0016079)2.79225200
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78821402
67axonal fasciculation (GO:0007413)2.78485431
68long-term memory (GO:0007616)2.75897385
69positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75351222
70cerebral cortex cell migration (GO:0021795)2.74914016
71positive regulation of vascular permeability (GO:0043117)2.74725760
72positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.72867169
73membrane depolarization during action potential (GO:0086010)2.72477642
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72243310
75protein polyglutamylation (GO:0018095)2.72054369
76spinal cord development (GO:0021510)2.71407553
77regulation of synapse assembly (GO:0051963)2.71068577
78regulation of synaptic vesicle transport (GO:1902803)2.70049766
79cerebellar granule cell differentiation (GO:0021707)2.69748201
80amino acid import (GO:0043090)2.67904510
81neuron projection extension (GO:1990138)2.67610064
82neuron fate determination (GO:0048664)2.66974661
83positive regulation of membrane potential (GO:0045838)2.66181146
84neuromuscular synaptic transmission (GO:0007274)2.66079909
85regulation of respiratory system process (GO:0044065)2.65649750
86reflex (GO:0060004)2.65116470
87regulation of respiratory gaseous exchange (GO:0043576)2.65110433
88exploration behavior (GO:0035640)2.64079523
89* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.63782474
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63654174
91regulation of synaptic transmission, GABAergic (GO:0032228)2.61210698
92* synapse assembly (GO:0007416)2.60262891
93cranial nerve morphogenesis (GO:0021602)2.59520018
94negative regulation of neurotransmitter transport (GO:0051589)2.59371397
95N-glycan processing (GO:0006491)2.58074890
96regulation of axon guidance (GO:1902667)2.57333547
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56812800
98neuronal action potential (GO:0019228)2.56340280
99retina layer formation (GO:0010842)2.56188864
100urinary tract smooth muscle contraction (GO:0014848)2.55486913
101limb bud formation (GO:0060174)2.54987322
102adult walking behavior (GO:0007628)2.54857251
103gamma-aminobutyric acid transport (GO:0015812)2.54808641
104appendage development (GO:0048736)2.54360797
105limb development (GO:0060173)2.54360797
106glutamate secretion (GO:0014047)2.54174651
107camera-type eye morphogenesis (GO:0048593)2.53715054
108synaptic vesicle docking involved in exocytosis (GO:0016081)2.53040664
109central nervous system projection neuron axonogenesis (GO:0021952)2.50889765
110retinal cone cell development (GO:0046549)2.50379715
111neurotransmitter secretion (GO:0007269)2.49097114
112retinal ganglion cell axon guidance (GO:0031290)2.49028798
113long-chain fatty acid biosynthetic process (GO:0042759)2.46772291
114protein localization to cilium (GO:0061512)2.46139171
115dendrite development (GO:0016358)2.45621566
116regulation of vesicle fusion (GO:0031338)2.45618555
117neuron migration (GO:0001764)2.45263459
118detection of calcium ion (GO:0005513)2.44779908
119membrane hyperpolarization (GO:0060081)2.44246380
120negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44141776
121learning (GO:0007612)2.43918499
122neuron remodeling (GO:0016322)2.43763781
123cAMP-mediated signaling (GO:0019933)2.43516025
124cochlea development (GO:0090102)2.43262722
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.43082425
126regulation of neurotransmitter secretion (GO:0046928)2.42422860
127regulation of timing of cell differentiation (GO:0048505)2.42114727
128axon cargo transport (GO:0008088)2.41291143
129dendritic spine organization (GO:0097061)2.40857447
130positive regulation of neurotransmitter secretion (GO:0001956)2.40686686
131adaptation of signaling pathway (GO:0023058)2.40189779
132sialylation (GO:0097503)2.39976669
133synaptic vesicle endocytosis (GO:0048488)2.38227352
134innervation (GO:0060384)2.37213485
135cerebellar Purkinje cell differentiation (GO:0021702)2.36682904
136negative regulation of synaptic transmission (GO:0050805)2.35697370
137positive regulation of dendritic spine development (GO:0060999)2.35318345
138photoreceptor cell differentiation (GO:0046530)2.34820471
139eye photoreceptor cell differentiation (GO:0001754)2.34820471
140cyclic nucleotide catabolic process (GO:0009214)2.34676914
141regulation of neuronal synaptic plasticity (GO:0048168)2.34580660
142membrane depolarization (GO:0051899)2.34384769
143artery development (GO:0060840)2.34309499
144hindbrain development (GO:0030902)2.33645706
145regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32792716
146axon ensheathment in central nervous system (GO:0032291)2.32721584
147central nervous system myelination (GO:0022010)2.32721584
148* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32335611
149synaptic transmission, cholinergic (GO:0007271)2.31364804
150response to pheromone (GO:0019236)2.30806355
151regulation of inositol phosphate biosynthetic process (GO:0010919)2.30039104
152behavioral response to ethanol (GO:0048149)2.29833364
153membrane assembly (GO:0071709)2.29320377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.30850786
2EZH2_22144423_ChIP-Seq_EOC_Human3.98270415
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.03884946
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67062583
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66261937
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59914570
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.49820562
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.45589642
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43520508
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42615167
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42585010
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38414726
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33479942
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26233788
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26233788
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23892635
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21175029
18TAF15_26573619_Chip-Seq_HEK293_Human2.16900133
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07447778
20ZNF274_21170338_ChIP-Seq_K562_Hela2.07279097
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02652628
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.99557234
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96363909
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95021792
25* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91806188
26P300_19829295_ChIP-Seq_ESCs_Human1.91354877
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.90137978
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89136689
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85909428
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.85405247
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81245444
32AR_21572438_ChIP-Seq_LNCaP_Human1.79102001
33* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79009892
34SMAD4_21799915_ChIP-Seq_A2780_Human1.74773547
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74187682
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.74152718
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74143945
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74031748
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.73565728
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73048889
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70805918
42FUS_26573619_Chip-Seq_HEK293_Human1.69068409
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68798524
44REST_21632747_ChIP-Seq_MESCs_Mouse1.64449962
45DROSHA_22980978_ChIP-Seq_HELA_Human1.63036291
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.62282627
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62013626
48IGF1R_20145208_ChIP-Seq_DFB_Human1.61309476
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.58775328
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57061244
51RNF2_27304074_Chip-Seq_NSC_Mouse1.53613794
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51586083
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48673155
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48547819
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.48421007
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.46129789
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45971219
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44163204
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39204970
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37942086
61VDR_22108803_ChIP-Seq_LS180_Human1.36640551
62TP53_18474530_ChIP-ChIP_U2OS_Human1.35033093
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34671497
64STAT3_23295773_ChIP-Seq_U87_Human1.34512085
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34311531
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.34199623
67AR_25329375_ChIP-Seq_VCAP_Human1.33585770
68ER_23166858_ChIP-Seq_MCF-7_Human1.33489280
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32010632
70TP53_16413492_ChIP-PET_HCT116_Human1.30591298
71P53_22387025_ChIP-Seq_ESCs_Mouse1.28819911
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27649217
73TCF4_23295773_ChIP-Seq_U87_Human1.25627479
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25392576
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25348392
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.24445272
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21098939
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.20961941
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20925516
80RUNX2_22187159_ChIP-Seq_PCA_Human1.20801868
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18687886
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16698782
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.16339796
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15716345
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15415657
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.15286321
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.14792366
88AHR_22903824_ChIP-Seq_MCF-7_Human1.14451458
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12211562
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12211562
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.11907380
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11799432
93P300_18555785_Chip-Seq_ESCs_Mouse1.11723928
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10743633
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10663873
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.10110482
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09834793
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09391029
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.08799859
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08669949
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.08662353
102SOX9_26525672_Chip-Seq_HEART_Mouse1.07781413
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07441823
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07271051
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07031801
106EWS_26573619_Chip-Seq_HEK293_Human1.06267681
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.06141827
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05822722
109CBP_20019798_ChIP-Seq_JUKART_Human1.05822722
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05345927
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03901688
112KDM2B_26808549_Chip-Seq_REH_Human1.03601918
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.03520610
114AR_19668381_ChIP-Seq_PC3_Human1.03277353
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02972241
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.02971208
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.02413959
118JUN_21703547_ChIP-Seq_K562_Human1.01376891
119BCAT_22108803_ChIP-Seq_LS180_Human1.00975845
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00689614
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99650667
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.97515793
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97047679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.39006522
2MP0004859_abnormal_synaptic_plasticity3.42942285
3MP0001486_abnormal_startle_reflex2.98640697
4MP0003635_abnormal_synaptic_transmissio2.74609834
5MP0009745_abnormal_behavioral_response2.68668789
6MP0000569_abnormal_digit_pigmentation2.63295918
7MP0001188_hyperpigmentation2.49663576
8MP0001968_abnormal_touch/_nociception2.48464836
9MP0009046_muscle_twitch2.47262955
10MP0005646_abnormal_pituitary_gland2.37278341
11MP0000566_synostosis2.36582734
12MP0002572_abnormal_emotion/affect_behav2.35187167
13MP0002736_abnormal_nociception_after2.34009381
14MP0002063_abnormal_learning/memory/cond2.28822769
15MP0002064_seizures2.25730584
16MP0004270_analgesia2.23594127
17MP0003121_genomic_imprinting2.15514976
18MP0005645_abnormal_hypothalamus_physiol2.13983397
19MP0002272_abnormal_nervous_system2.09918598
20MP0002735_abnormal_chemical_nociception2.07677700
21MP0006292_abnormal_olfactory_placode2.03899181
22MP0002102_abnormal_ear_morphology2.01388769
23MP0005423_abnormal_somatic_nervous1.98553863
24MP0002734_abnormal_mechanical_nocicepti1.96685444
25MP0001529_abnormal_vocalization1.94351263
26MP0002067_abnormal_sensory_capabilities1.87662452
27MP0005171_absent_coat_pigmentation1.85078951
28MP0000778_abnormal_nervous_system1.84671034
29MP0001440_abnormal_grooming_behavior1.84589782
30MP0004742_abnormal_vestibular_system1.78990199
31MP0001501_abnormal_sleep_pattern1.75764824
32MP0006276_abnormal_autonomic_nervous1.70700665
33MP0002557_abnormal_social/conspecific_i1.67795016
34MP0009780_abnormal_chondrocyte_physiolo1.66949026
35MP0005551_abnormal_eye_electrophysiolog1.65997196
36MP0005409_darkened_coat_color1.65618759
37MP0003136_yellow_coat_color1.62705288
38MP0001984_abnormal_olfaction1.61939711
39MP0008789_abnormal_olfactory_epithelium1.56806624
40MP0002184_abnormal_innervation1.48454448
41MP0004133_heterotaxia1.47477311
42MP0003787_abnormal_imprinting1.45956263
43MP0001502_abnormal_circadian_rhythm1.42412581
44MP0005248_abnormal_Harderian_gland1.38925547
45MP0001970_abnormal_pain_threshold1.37184746
46MP0004924_abnormal_behavior1.37130516
47MP0005386_behavior/neurological_phenoty1.37130516
48MP0003283_abnormal_digestive_organ1.33530540
49MP0001963_abnormal_hearing_physiology1.32122339
50MP0001905_abnormal_dopamine_level1.31265041
51MP0003890_abnormal_embryonic-extraembry1.30595150
52MP0000631_abnormal_neuroendocrine_gland1.30395028
53MP0004142_abnormal_muscle_tone1.29214316
54MP0000026_abnormal_inner_ear1.29208065
55MP0008877_abnormal_DNA_methylation1.27914847
56MP0000049_abnormal_middle_ear1.25244815
57MP0003122_maternal_imprinting1.23818998
58MP0002876_abnormal_thyroid_physiology1.22392150
59MP0002733_abnormal_thermal_nociception1.21739242
60MP0008569_lethality_at_weaning1.21499713
61MP0010386_abnormal_urinary_bladder1.21086670
62MP0005187_abnormal_penis_morphology1.17822805
63MP0002882_abnormal_neuron_morphology1.17822249
64MP0000955_abnormal_spinal_cord1.17801605
65MP0003123_paternal_imprinting1.14207587
66MP0002234_abnormal_pharynx_morphology1.11025580
67MP0002909_abnormal_adrenal_gland1.10972662
68MP0005379_endocrine/exocrine_gland_phen1.10832567
69MP0001485_abnormal_pinna_reflex1.09219224
70MP0002638_abnormal_pupillary_reflex1.06123442
71MP0002233_abnormal_nose_morphology1.05787552
72MP0003879_abnormal_hair_cell1.05463902
73MP0006072_abnormal_retinal_apoptosis1.05119629
74MP0002277_abnormal_respiratory_mucosa1.04332707
75MP0002752_abnormal_somatic_nervous1.03108025
76MP0005253_abnormal_eye_physiology1.02051795
77MP0002822_catalepsy1.01449717
78MP0001986_abnormal_taste_sensitivity0.99843535
79MP0001346_abnormal_lacrimal_gland0.99631975
80MP0009250_abnormal_appendicular_skeleto0.98397412
81MP0002066_abnormal_motor_capabilities/c0.98106358
82MP0004484_altered_response_of0.97558619
83MP0002249_abnormal_larynx_morphology0.97505741
84MP0004885_abnormal_endolymph0.97232308
85MP0002751_abnormal_autonomic_nervous0.96844946
86MP0010030_abnormal_orbit_morphology0.96656897
87MP0000920_abnormal_myelination0.96647131
88MP0003937_abnormal_limbs/digits/tail_de0.96152513
89MP0001177_atelectasis0.95709235
90MP0003878_abnormal_ear_physiology0.95112059
91MP0005377_hearing/vestibular/ear_phenot0.95112059
92MP0003861_abnormal_nervous_system0.92935639
93MP0003755_abnormal_palate_morphology0.92164082
94MP0003011_delayed_dark_adaptation0.89887016
95MP0004085_abnormal_heartbeat0.89630841
96MP0008004_abnormal_stomach_pH0.89464097
97MP0000579_abnormal_nail_morphology0.89453463
98MP0003633_abnormal_nervous_system0.87323749
99MP0003690_abnormal_glial_cell0.87145748
100MP0003938_abnormal_ear_development0.86773842
101MP0003385_abnormal_body_wall0.84605193
102MP0000427_abnormal_hair_cycle0.83146571
103MP0000015_abnormal_ear_pigmentation0.83076366
104MP0003631_nervous_system_phenotype0.82484413
105MP0003950_abnormal_plasma_membrane0.82338225
106MP0004811_abnormal_neuron_physiology0.81523567
107MP0002229_neurodegeneration0.80681122
108MP0002938_white_spotting0.79057536
109MP0003183_abnormal_peptide_metabolism0.78946970
110MP0001286_abnormal_eye_development0.78791999
111MP0003329_amyloid_beta_deposits0.78771374
112MP0004215_abnormal_myocardial_fiber0.78615110
113MP0002152_abnormal_brain_morphology0.77747863
114MP0003119_abnormal_digestive_system0.77429767
115MP0001299_abnormal_eye_distance/0.77371874
116MP0004145_abnormal_muscle_electrophysio0.77369771
117MP0002069_abnormal_eating/drinking_beha0.76623820
118MP0002177_abnormal_outer_ear0.74005969
119MP0002653_abnormal_ependyma_morphology0.73799375
120MP0002090_abnormal_vision0.73426686
121MP0005391_vision/eye_phenotype0.73083222
122MP0005499_abnormal_olfactory_system0.72791234
123MP0005394_taste/olfaction_phenotype0.72791234
124MP0002163_abnormal_gland_morphology0.71489803
125MP0005503_abnormal_tendon_morphology0.71271312
126MP0004381_abnormal_hair_follicle0.70965053
127MP0004134_abnormal_chest_morphology0.70879184
128MP0005195_abnormal_posterior_eye0.70404268
129MP0003634_abnormal_glial_cell0.70314629
130MP0005595_abnormal_vascular_smooth0.69430474
131MP0000678_abnormal_parathyroid_gland0.69306820

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.72308594
2Hyperventilation (HP:0002883)4.60188520
3Febrile seizures (HP:0002373)4.54797510
4Epileptic encephalopathy (HP:0200134)4.30995792
5Aplasia involving bones of the upper limbs (HP:0009823)3.48176216
6Aplasia of the phalanges of the hand (HP:0009802)3.48176216
7Aplasia involving bones of the extremities (HP:0009825)3.48176216
8Focal seizures (HP:0007359)3.33708314
9Polyphagia (HP:0002591)3.28906471
10Limb dystonia (HP:0002451)3.22725079
11Atonic seizures (HP:0010819)3.07010624
12Progressive cerebellar ataxia (HP:0002073)3.06120956
13Broad-based gait (HP:0002136)2.89324950
14Nephronophthisis (HP:0000090)2.86946720
15Dynein arm defect of respiratory motile cilia (HP:0012255)2.79422148
16Absent/shortened dynein arms (HP:0200106)2.79422148
17Action tremor (HP:0002345)2.77006130
18Septo-optic dysplasia (HP:0100842)2.71676828
19Abnormality of midbrain morphology (HP:0002418)2.70404488
20Molar tooth sign on MRI (HP:0002419)2.70404488
21Abnormality of the labia minora (HP:0012880)2.67008713
22Gaze-evoked nystagmus (HP:0000640)2.64359863
23Aplasia cutis congenita (HP:0001057)2.61570673
24Pancreatic fibrosis (HP:0100732)2.60851061
25True hermaphroditism (HP:0010459)2.60585694
26Pachygyria (HP:0001302)2.54118078
27Protruding tongue (HP:0010808)2.50798086
28Agitation (HP:0000713)2.48728131
29Pendular nystagmus (HP:0012043)2.44983383
30Failure to thrive in infancy (HP:0001531)2.41036076
31Dialeptic seizures (HP:0011146)2.40513134
32Lissencephaly (HP:0001339)2.39889780
33Pancreatic cysts (HP:0001737)2.39070525
34Congenital stationary night blindness (HP:0007642)2.36613127
35Generalized tonic-clonic seizures (HP:0002069)2.36572571
36Absence seizures (HP:0002121)2.35059205
37Congenital sensorineural hearing impairment (HP:0008527)2.35004933
38Mixed hearing impairment (HP:0000410)2.33871428
39Short 4th metacarpal (HP:0010044)2.33793887
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33793887
41Absent speech (HP:0001344)2.33615026
42Anterior segment dysgenesis (HP:0007700)2.29081846
43Excessive salivation (HP:0003781)2.27825472
44Drooling (HP:0002307)2.27825472
45Abnormal eating behavior (HP:0100738)2.25847252
46Specific learning disability (HP:0001328)2.24636342
47Long nose (HP:0003189)2.24049187
48Widely spaced teeth (HP:0000687)2.23645991
49Amblyopia (HP:0000646)2.23521753
50Morphological abnormality of the middle ear (HP:0008609)2.22570972
51Hemiparesis (HP:0001269)2.22211093
52Blue irides (HP:0000635)2.21271428
53Medial flaring of the eyebrow (HP:0010747)2.19849679
54Sleep apnea (HP:0010535)2.18212706
55Abnormality of incisor morphology (HP:0011063)2.18201125
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.17820013
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17820013
58Parakeratosis (HP:0001036)2.17572479
59Narrow nasal bridge (HP:0000446)2.16769246
60Fair hair (HP:0002286)2.16050960
61Decreased central vision (HP:0007663)2.15138357
62Abnormal ciliary motility (HP:0012262)2.13367822
63Cupped ear (HP:0000378)2.12434170
64Genetic anticipation (HP:0003743)2.11607176
65Type II lissencephaly (HP:0007260)2.10457929
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.09466910
67Gait imbalance (HP:0002141)2.08988940
68Nasolacrimal duct obstruction (HP:0000579)2.07631915
69Optic nerve hypoplasia (HP:0000609)2.06648957
70Abnormality of the lacrimal duct (HP:0011481)2.05646718
71Rib fusion (HP:0000902)2.05508486
72Nephrogenic diabetes insipidus (HP:0009806)2.03978345
73Chronic hepatic failure (HP:0100626)2.03829079
74Hypsarrhythmia (HP:0002521)2.03098960
75Abnormality of the corticospinal tract (HP:0002492)2.03092689
76Visual hallucinations (HP:0002367)2.02611144
77Absent eyebrow (HP:0002223)2.02033924
78Absent septum pellucidum (HP:0001331)2.01965737
79Humeroradial synostosis (HP:0003041)2.01830261
80Synostosis involving the elbow (HP:0003938)2.01830261
81Hypoplasia of the brainstem (HP:0002365)2.01653322
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01653322
83Cortical dysplasia (HP:0002539)2.00461468
84Abnormality of the nasolacrimal system (HP:0000614)2.00431777
85Decreased muscle mass (HP:0003199)1.99318978
86Postaxial foot polydactyly (HP:0001830)1.96733967
87Generalized hypopigmentation of hair (HP:0011358)1.96658527
88Postaxial hand polydactyly (HP:0001162)1.95656114
89Truncal ataxia (HP:0002078)1.95601842
90Epileptiform EEG discharges (HP:0011182)1.93554169
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93303465
92Abnormal hair whorl (HP:0010721)1.93174766
93Labial hypoplasia (HP:0000066)1.92866045
94Congenital primary aphakia (HP:0007707)1.92564284
95Abnormality of the 4th metacarpal (HP:0010012)1.91963760
96Poor coordination (HP:0002370)1.91433038
97Broad foot (HP:0001769)1.90005604
98Abnormality of salivation (HP:0100755)1.88943499
99Abnormality of the right ventricle (HP:0001707)1.88859640
100Neurofibrillary tangles (HP:0002185)1.88487085
101Gastroesophageal reflux (HP:0002020)1.87299159
102White forelock (HP:0002211)1.87008398
103Oligomenorrhea (HP:0000876)1.86678412
104Narrow forehead (HP:0000341)1.86018168
105Ulnar claw (HP:0001178)1.85956024
106High anterior hairline (HP:0009890)1.85308550
107Tented upper lip vermilion (HP:0010804)1.84979574
108Megalencephaly (HP:0001355)1.84850837
109Hypothermia (HP:0002045)1.84790368
110Short foot (HP:0001773)1.84118105
111Abnormality of calcium-phosphate metabolism (HP:0100530)1.83884230
112Tubulointerstitial nephritis (HP:0001970)1.83705034
113Myokymia (HP:0002411)1.83181190
114Poor suck (HP:0002033)1.83005358
115Dysdiadochokinesis (HP:0002075)1.82901963
116Abnormality of the septum pellucidum (HP:0007375)1.82829196
117Fetal akinesia sequence (HP:0001989)1.80324185
118Abnormality of the anterior chamber (HP:0000593)1.80323022
119Aplasia/Hypoplasia of the lens (HP:0008063)1.80284472
120Growth hormone deficiency (HP:0000824)1.78741863
121Diplopia (HP:0000651)1.77928539
122Abnormality of binocular vision (HP:0011514)1.77928539
123Inability to walk (HP:0002540)1.77381569
124Hip dysplasia (HP:0001385)1.77068225
125EEG with generalized epileptiform discharges (HP:0011198)1.76431735
126Hepatoblastoma (HP:0002884)1.76267609
127Sclerocornea (HP:0000647)1.76067441
128Cutaneous syndactyly (HP:0012725)1.75254679
129Genital tract atresia (HP:0001827)1.75182601
130Abnormality of the axillary hair (HP:0100134)1.74856608
131Abnormality of secondary sexual hair (HP:0009888)1.74856608
132Adrenal hypoplasia (HP:0000835)1.74544882
133Patchy hypopigmentation of hair (HP:0011365)1.73019658
134Vaginal atresia (HP:0000148)1.72876527
135Exotropia (HP:0000577)1.72697025
136Keratoconus (HP:0000563)1.71433137
137Increased corneal curvature (HP:0100692)1.71433137
138Esotropia (HP:0000565)1.71018049
139Anophthalmia (HP:0000528)1.70607356
140Prostate neoplasm (HP:0100787)1.69779476
141Abnormality of the columella (HP:0009929)1.69678911
142Morphological abnormality of the pyramidal tract (HP:0002062)1.69463301
143Bradycardia (HP:0001662)1.69162069
144Retinal dysplasia (HP:0007973)1.68849127
145Scanning speech (HP:0002168)1.68440263
146Midline defect of the nose (HP:0004122)1.67485891
147Spastic tetraplegia (HP:0002510)1.67077511
148Abnormality of the renal medulla (HP:0100957)1.66635405
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.66259060
150Hypoplastic heart (HP:0001961)1.65986336
151Anomalous pulmonary venous return (HP:0010772)1.65527849
152Cutaneous finger syndactyly (HP:0010554)1.65418758
153Shawl scrotum (HP:0000049)1.65233912
154Abnormality of abdominal situs (HP:0011620)1.65056230
155Abdominal situs inversus (HP:0003363)1.65056230
156Abnormal respiratory epithelium morphology (HP:0012253)1.64807202
157Abnormal respiratory motile cilium morphology (HP:0005938)1.64807202
158Cystic liver disease (HP:0006706)1.64362959
159Hypoplastic female external genitalia (HP:0012815)1.64125375
160Occipital encephalocele (HP:0002085)1.63902824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.45870724
2TNIK3.56606366
3NTRK33.18679845
4EPHA43.17237339
5MAP4K22.79566214
6MAP2K72.67264667
7SIK32.57963971
8INSRR2.57093977
9DYRK22.02882093
10MAP3K41.92526277
11PINK11.90926701
12NEK61.78217848
13BMPR1B1.77786872
14MAPK131.75317362
15MARK11.65571839
16CSNK1G21.63646305
17BCR1.62917982
18BRD41.61726177
19BMPR21.60515794
20NTRK21.59916282
21MKNK21.57805793
22GRK11.57734589
23TIE11.50689543
24PRPF4B1.45452497
25SIK21.39235721
26RIPK41.37628103
27PLK21.36456909
28OXSR11.33169634
29MUSK1.29158650
30GRK71.25188802
31CSNK1G31.24084141
32PKN11.20867626
33PRKCE1.19308344
34AKT31.16805049
35ADRBK21.16147784
36MAP3K121.14827913
37PRKD31.11419888
38FGFR21.08209410
39SGK21.07969315
40SGK4941.07873051
41SGK2231.07873051
42CDK31.06924159
43CSNK1A1L1.06759487
44CSNK1G11.06431662
45CAMK2A1.05887339
46CDK191.05271730
47EPHA31.04846976
48FRK1.02632301
49GRK51.02365877
50WNK41.02348525
51FES0.98898571
52PRKCG0.97329233
53YES10.95639506
54ERBB30.92058167
55MINK10.91307713
56MAPK70.88649908
57CAMKK20.86396864
58CDK50.86385936
59WNK30.84693220
60PHKG10.84333685
61PHKG20.84333685
62FER0.82250280
63CAMKK10.81755963
64STK390.81454046
65MAP2K40.81040495
66FGR0.80713365
67MAP3K130.80002052
68WNK10.79138513
69PIK3CA0.78531257
70SGK10.78101889
71DYRK1A0.78051123
72CDK80.76580546
73PAK60.75596398
74LIMK10.75317554
75MARK20.73168452
76PRKCZ0.72684438
77CAMK2B0.72551158
78DYRK30.72244730
79MAP3K90.72069857
80CAMK10.71792216
81MKNK10.70744762
82STK160.69366639
83STK38L0.68952558
84PRKD20.68167764
85DMPK0.67851278
86TYRO30.67013040
87IRAK10.66211104
88UHMK10.63836768
89CAMK2D0.63797875
90CAMK1G0.63797674
91MAPK120.63294187
92DAPK20.61779427
93NUAK10.60026360
94EIF2AK20.57016671
95BLK0.55642405
96ADRBK10.55510171
97PBK0.54779935
98CDK140.53651734
99EPHB20.53138530
100PRKG10.53069331
101PNCK0.52418780
102IRAK20.51072215
103KSR10.49838357
104MAP3K140.49144080
105TRIM280.48369661
106NTRK10.47120543
107PRKACA0.46483000
108TNK20.45270223
109DYRK1B0.45145148
110PTK2B0.44978148
111ZAK0.44757326
112PRKAA10.43535903
113CDK180.43431247
114LATS10.43271714
115CDK150.42294859
116ERBB20.41045643
117RIPK10.40813831
118ERBB40.39432506
119PAK30.38917532
120MAP3K20.38730691
121PRKCH0.38349909
122STK110.37930840
123CAMK40.37768401
124PRKCQ0.37503371
125CDK11A0.37153421
126ROCK20.37051625
127MAPKAPK50.36646078
128SGK30.36540240
129ROCK10.36536989
130IRAK30.35678585
131PRKCA0.34034410
132MAPK150.33899374
133CSNK1A10.33664385
134CAMK2G0.33378449
135CSNK1D0.32932144

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.89759889
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62704891
3Glutamatergic synapse_Homo sapiens_hsa047242.58224150
4Morphine addiction_Homo sapiens_hsa050322.55881857
5GABAergic synapse_Homo sapiens_hsa047272.39101664
6Circadian entrainment_Homo sapiens_hsa047132.30925573
7Taste transduction_Homo sapiens_hsa047422.12880798
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06834942
9Serotonergic synapse_Homo sapiens_hsa047262.06456118
10Synaptic vesicle cycle_Homo sapiens_hsa047212.04491782
11Olfactory transduction_Homo sapiens_hsa047401.96133341
12Insulin secretion_Homo sapiens_hsa049111.91458236
13Phototransduction_Homo sapiens_hsa047441.90794061
14Salivary secretion_Homo sapiens_hsa049701.86406608
15Amphetamine addiction_Homo sapiens_hsa050311.85341817
16Long-term potentiation_Homo sapiens_hsa047201.79838244
17Calcium signaling pathway_Homo sapiens_hsa040201.67960604
18Long-term depression_Homo sapiens_hsa047301.66058632
19Axon guidance_Homo sapiens_hsa043601.65792257
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62073719
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60474912
22Dopaminergic synapse_Homo sapiens_hsa047281.59890720
23Collecting duct acid secretion_Homo sapiens_hsa049661.59870941
24Renin secretion_Homo sapiens_hsa049241.57333978
25Cholinergic synapse_Homo sapiens_hsa047251.56218635
26Butanoate metabolism_Homo sapiens_hsa006501.48004896
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41051353
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41029693
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39659786
30Cocaine addiction_Homo sapiens_hsa050301.36890169
31Gastric acid secretion_Homo sapiens_hsa049711.33952443
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29023139
33Oxytocin signaling pathway_Homo sapiens_hsa049211.27714548
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26916788
35cAMP signaling pathway_Homo sapiens_hsa040241.22655047
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22378788
37Rheumatoid arthritis_Homo sapiens_hsa053231.20727203
38Sphingolipid metabolism_Homo sapiens_hsa006001.18839556
39Hippo signaling pathway_Homo sapiens_hsa043901.13810498
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09055287
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08754177
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06339315
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02507029
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00246261
45Vibrio cholerae infection_Homo sapiens_hsa051100.98490909
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98187885
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96719147
48Circadian rhythm_Homo sapiens_hsa047100.96334747
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.96241945
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94613236
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90343821
52Gap junction_Homo sapiens_hsa045400.89246143
53Dilated cardiomyopathy_Homo sapiens_hsa054140.86861130
54Ras signaling pathway_Homo sapiens_hsa040140.86801399
55African trypanosomiasis_Homo sapiens_hsa051430.86317671
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86268104
57Pancreatic secretion_Homo sapiens_hsa049720.85982982
58Dorso-ventral axis formation_Homo sapiens_hsa043200.85459634
59Type II diabetes mellitus_Homo sapiens_hsa049300.84993720
60Ovarian steroidogenesis_Homo sapiens_hsa049130.84818718
61GnRH signaling pathway_Homo sapiens_hsa049120.84762040
62Melanogenesis_Homo sapiens_hsa049160.82739048
63ErbB signaling pathway_Homo sapiens_hsa040120.81848217
64Nitrogen metabolism_Homo sapiens_hsa009100.81372384
65Linoleic acid metabolism_Homo sapiens_hsa005910.81059583
66Ether lipid metabolism_Homo sapiens_hsa005650.80658548
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80576592
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80032212
69Cardiac muscle contraction_Homo sapiens_hsa042600.79047570
70Parkinsons disease_Homo sapiens_hsa050120.78546021
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78415026
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77547508
73beta-Alanine metabolism_Homo sapiens_hsa004100.75760250
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74402908
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73446199
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73262891
77Selenocompound metabolism_Homo sapiens_hsa004500.70940309
78Regulation of autophagy_Homo sapiens_hsa041400.69993692
79MAPK signaling pathway_Homo sapiens_hsa040100.69963715
80Choline metabolism in cancer_Homo sapiens_hsa052310.69655121
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68765101
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68079521
83Wnt signaling pathway_Homo sapiens_hsa043100.67511654
84Steroid biosynthesis_Homo sapiens_hsa001000.67011673
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66973913
86Oxidative phosphorylation_Homo sapiens_hsa001900.64465641
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64357826
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.64347047
89Phagosome_Homo sapiens_hsa041450.63335656
90Type I diabetes mellitus_Homo sapiens_hsa049400.63270837
91Rap1 signaling pathway_Homo sapiens_hsa040150.63129906
92Alzheimers disease_Homo sapiens_hsa050100.60861079
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57307914
94Melanoma_Homo sapiens_hsa052180.57080182
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.55654480
96Oocyte meiosis_Homo sapiens_hsa041140.55633742
97Bile secretion_Homo sapiens_hsa049760.54554522
98Autoimmune thyroid disease_Homo sapiens_hsa053200.53124172
99Tight junction_Homo sapiens_hsa045300.52887969
100Inositol phosphate metabolism_Homo sapiens_hsa005620.52838671
101Fatty acid elongation_Homo sapiens_hsa000620.50415580
102Estrogen signaling pathway_Homo sapiens_hsa049150.49718666
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48098597
104Tryptophan metabolism_Homo sapiens_hsa003800.47801043
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46926059
106Protein digestion and absorption_Homo sapiens_hsa049740.46867674
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46554149
108Peroxisome_Homo sapiens_hsa041460.44492359
109Histidine metabolism_Homo sapiens_hsa003400.44441235
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43396777
111Basal transcription factors_Homo sapiens_hsa030220.42338457
112Fatty acid biosynthesis_Homo sapiens_hsa000610.42157961
113Lysine degradation_Homo sapiens_hsa003100.41358719
114Mineral absorption_Homo sapiens_hsa049780.41238247
115Huntingtons disease_Homo sapiens_hsa050160.40937724
116Glioma_Homo sapiens_hsa052140.40494072
117Propanoate metabolism_Homo sapiens_hsa006400.40246070
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39160558
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.38726389
120ECM-receptor interaction_Homo sapiens_hsa045120.36958000
121Thyroid hormone synthesis_Homo sapiens_hsa049180.33266842
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32908090
123Chemokine signaling pathway_Homo sapiens_hsa040620.32495424
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30456691
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28684932
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28101457
127Basal cell carcinoma_Homo sapiens_hsa052170.26893536
128Alcoholism_Homo sapiens_hsa050340.25919593
129Hedgehog signaling pathway_Homo sapiens_hsa043400.25275497
130Glucagon signaling pathway_Homo sapiens_hsa049220.24724624

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