PCDHB15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.36456015
2nucleobase catabolic process (GO:0046113)4.94738704
3neuron cell-cell adhesion (GO:0007158)4.55665104
4vocalization behavior (GO:0071625)4.39396783
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36140931
6synaptic vesicle exocytosis (GO:0016079)4.18041102
7protein localization to synapse (GO:0035418)4.14368829
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00504273
9auditory behavior (GO:0031223)3.97767288
10establishment of mitochondrion localization (GO:0051654)3.97524717
11short-term memory (GO:0007614)3.95429333
12layer formation in cerebral cortex (GO:0021819)3.94985223
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.93259021
14glutamate receptor signaling pathway (GO:0007215)3.92603405
15negative regulation of oligodendrocyte differentiation (GO:0048715)3.86844288
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85830122
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80947154
18presynaptic membrane assembly (GO:0097105)3.80946367
19calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.79610586
20neuronal action potential propagation (GO:0019227)3.78812734
21synaptic vesicle maturation (GO:0016188)3.76705632
22innervation (GO:0060384)3.74951500
23glutamate secretion (GO:0014047)3.71686207
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.69891875
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.69733726
26limb bud formation (GO:0060174)3.64688830
27regulation of synaptic vesicle exocytosis (GO:2000300)3.63337276
28presynaptic membrane organization (GO:0097090)3.62738491
29head development (GO:0060322)3.57650909
30neuron recognition (GO:0008038)3.55733628
31postsynaptic membrane organization (GO:0001941)3.50165823
32mechanosensory behavior (GO:0007638)3.48846298
33locomotory exploration behavior (GO:0035641)3.48123416
34axonal fasciculation (GO:0007413)3.45456212
35olfactory bulb development (GO:0021772)3.44205359
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.43118319
37neuronal ion channel clustering (GO:0045161)3.41072360
38cerebellar Purkinje cell differentiation (GO:0021702)3.40462891
39positive regulation of dendritic spine morphogenesis (GO:0061003)3.38811273
40regulation of glutamate receptor signaling pathway (GO:1900449)3.36973104
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.36408800
42synaptic transmission, glutamatergic (GO:0035249)3.32287905
43dendritic spine morphogenesis (GO:0060997)3.31578034
44neuron-neuron synaptic transmission (GO:0007270)3.28076343
45hippocampus development (GO:0021766)3.27901254
46positive regulation of synapse maturation (GO:0090129)3.21873828
47neurotransmitter secretion (GO:0007269)3.19968784
48behavioral response to nicotine (GO:0035095)3.19486391
49cell migration in hindbrain (GO:0021535)3.18207548
50mitochondrion transport along microtubule (GO:0047497)3.16673379
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16673379
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15477593
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15366386
54cellular potassium ion homeostasis (GO:0030007)3.14774336
55neurotransmitter-gated ion channel clustering (GO:0072578)3.13886463
56positive regulation of synapse assembly (GO:0051965)3.07480459
57nonmotile primary cilium assembly (GO:0035058)3.07118740
58response to auditory stimulus (GO:0010996)3.05887061
59regulation of postsynaptic membrane potential (GO:0060078)3.05142852
60cell proliferation in forebrain (GO:0021846)3.04846201
61regulation of synaptic vesicle transport (GO:1902803)3.04453056
62axon extension (GO:0048675)3.03222559
63substrate-independent telencephalic tangential migration (GO:0021826)3.02624852
64substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.02624852
65dendrite morphogenesis (GO:0048813)3.01360861
66retinal ganglion cell axon guidance (GO:0031290)3.01356772
67exploration behavior (GO:0035640)3.01026938
68neuron remodeling (GO:0016322)2.98726038
69startle response (GO:0001964)2.97519118
70synapse assembly (GO:0007416)2.96292683
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95776453
72gamma-aminobutyric acid transport (GO:0015812)2.93998158
73cerebellar granule cell differentiation (GO:0021707)2.93355680
74positive regulation of action potential (GO:0045760)2.92882279
75membrane hyperpolarization (GO:0060081)2.92175594
76regulation of synaptic transmission, glutamatergic (GO:0051966)2.90835371
77response to pheromone (GO:0019236)2.89028781
78long-term synaptic potentiation (GO:0060291)2.87958410
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86221911
80spinal cord development (GO:0021510)2.85986653
81regulation of neuronal synaptic plasticity (GO:0048168)2.85884508
82apical protein localization (GO:0045176)2.85212800
83somite development (GO:0061053)2.83697632
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83243465
85synapse organization (GO:0050808)2.82495350
86positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79648608
87positive regulation of membrane potential (GO:0045838)2.79380332
88regulation of dendritic spine morphogenesis (GO:0061001)2.79275491
89neurofilament cytoskeleton organization (GO:0060052)2.76409512
90regulation of synapse structural plasticity (GO:0051823)2.76294056
91regulation of long-term neuronal synaptic plasticity (GO:0048169)2.75479525
92transmission of nerve impulse (GO:0019226)2.74316925
93regulation of female receptivity (GO:0045924)2.72331182
94membrane assembly (GO:0071709)2.71966118
95neurotransmitter transport (GO:0006836)2.71917684
96response to histamine (GO:0034776)2.70302811
97membrane depolarization (GO:0051899)2.69991846
98female mating behavior (GO:0060180)2.69414986
99negative regulation of glial cell differentiation (GO:0045686)2.69389426
100long term synaptic depression (GO:0060292)2.68683068
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67989816
102C4-dicarboxylate transport (GO:0015740)2.67808548
103neuron migration (GO:0001764)2.67687673
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65171655
105forebrain neuron differentiation (GO:0021879)2.64658065
106regulation of synapse assembly (GO:0051963)2.64140574
107intraciliary transport (GO:0042073)2.63883621
108regulation of neurotransmitter secretion (GO:0046928)2.63833083
109synaptic vesicle endocytosis (GO:0048488)2.62680065
110regulation of synaptic plasticity (GO:0048167)2.61338466
111adult walking behavior (GO:0007628)2.60933719
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59872145
113dendrite development (GO:0016358)2.59064256
114regulation of voltage-gated calcium channel activity (GO:1901385)2.58959948
115membrane depolarization during action potential (GO:0086010)2.58863315
116cerebral cortex radially oriented cell migration (GO:0021799)2.57961633
117cell differentiation in hindbrain (GO:0021533)2.57692526
118limb development (GO:0060173)2.57551431
119appendage development (GO:0048736)2.57551431
120long-term memory (GO:0007616)2.57071297
121ephrin receptor signaling pathway (GO:0048013)2.56064674
122activation of protein kinase A activity (GO:0034199)2.55848396
123regulation of synapse maturation (GO:0090128)2.55231864
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54713589
125regulation of synaptic transmission, GABAergic (GO:0032228)2.54234164
126cochlea development (GO:0090102)2.54050391
127negative regulation of microtubule polymerization (GO:0031115)2.52753797
128central nervous system projection neuron axonogenesis (GO:0021952)2.51785226
129sequestering of actin monomers (GO:0042989)2.50466633
130protein localization to cilium (GO:0061512)2.50070539
131cerebral cortex cell migration (GO:0021795)2.49681678
132neuron projection extension (GO:1990138)2.49564990
133negative regulation of neurotransmitter transport (GO:0051589)2.49486970
134negative regulation of heart rate (GO:0010459)2.49474768
135negative regulation of axonogenesis (GO:0050771)2.49419025
136cardiac ventricle formation (GO:0003211)2.48074876
137* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.48028348
138sodium ion export (GO:0071436)2.47862593
139regulation of vesicle fusion (GO:0031338)2.46840438
140regulation of dendritic spine development (GO:0060998)2.46666793
141regulation of neurotransmitter transport (GO:0051588)2.46660724
142positive regulation of dendritic spine development (GO:0060999)2.46519526
143regulation of collateral sprouting (GO:0048670)2.45090803
144regulation of synapse organization (GO:0050807)2.44934069
145learning (GO:0007612)2.44888883
146spinal cord association neuron differentiation (GO:0021527)2.43903509
147positive regulation of neurotransmitter transport (GO:0051590)2.43847925
148regulation of membrane repolarization (GO:0060306)2.43346381
149positive regulation of mitochondrial fission (GO:0090141)2.42898053
150positive regulation of synaptic transmission (GO:0050806)2.42727683
151negative regulation of gliogenesis (GO:0014014)2.38996242
152cardiac chamber formation (GO:0003207)2.37138843
153axonogenesis (GO:0007409)2.35617065
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35115927
155synaptic transmission, cholinergic (GO:0007271)2.35079810
156glycosphingolipid biosynthetic process (GO:0006688)2.34819503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61786365
2GBX2_23144817_ChIP-Seq_PC3_Human3.89613715
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.34666670
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09811250
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96953006
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90730166
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65658779
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.62980028
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62043279
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62043279
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55062402
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50695673
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.49974373
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45532016
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45374420
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32831836
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27481392
18TAF15_26573619_Chip-Seq_HEK293_Human2.17683342
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12321819
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.09221681
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.08811121
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08648994
23DROSHA_22980978_ChIP-Seq_HELA_Human2.08315188
24AR_21572438_ChIP-Seq_LNCaP_Human2.05978513
25REST_21632747_ChIP-Seq_MESCs_Mouse1.99022593
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83176664
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81203132
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.80119981
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77221605
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74067062
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73910538
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72263540
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.65076035
34SMAD4_21799915_ChIP-Seq_A2780_Human1.63602437
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.61154202
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61060721
37P300_19829295_ChIP-Seq_ESCs_Human1.59495002
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58640343
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.57232664
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56289978
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56169848
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54041358
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.51461997
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.49144121
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.48545543
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48036564
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47474890
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46448297
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45735187
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44128817
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41473957
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40654120
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40193112
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39883305
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39312219
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36355302
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.35941749
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33279115
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.32842714
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32576622
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31201875
62EWS_26573619_Chip-Seq_HEK293_Human1.30515255
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29809490
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29493940
65AR_25329375_ChIP-Seq_VCAP_Human1.27890074
66STAT3_23295773_ChIP-Seq_U87_Human1.24597147
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.23028940
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.22421595
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22233765
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21703402
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21404686
72ZNF274_21170338_ChIP-Seq_K562_Hela1.20320137
73AR_19668381_ChIP-Seq_PC3_Human1.16957786
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16387605
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.15875616
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15373258
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.14820429
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14559594
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14544216
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.14326978
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13533965
82BCAT_22108803_ChIP-Seq_LS180_Human1.13527883
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13228188
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12405377
85FUS_26573619_Chip-Seq_HEK293_Human1.12375806
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11265071
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.10978349
88AHR_22903824_ChIP-Seq_MCF-7_Human1.09127534
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09063970
90TCF4_23295773_ChIP-Seq_U87_Human1.07905343
91TP53_18474530_ChIP-ChIP_U2OS_Human1.07117275
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07015090
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07015090
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06158181
95RUNX2_22187159_ChIP-Seq_PCA_Human1.05591902
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05265705
97IGF1R_20145208_ChIP-Seq_DFB_Human1.05040969
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04546289
99SOX9_26525672_Chip-Seq_HEART_Mouse1.04530991
100ER_23166858_ChIP-Seq_MCF-7_Human1.04191064
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04190195
102RNF2_27304074_Chip-Seq_NSC_Mouse1.04084402
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03722498
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03439346
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.02696192
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02655875
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02354642
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02232925
109TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01962617
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01777427
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.01712604
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01647736
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00459692
114VDR_22108803_ChIP-Seq_LS180_Human0.99015103
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98995234
116KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98282196
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98183327
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97674947
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97331756
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97295159
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.95453637
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.95008171
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.94996975
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.93988318
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93364688
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93364688
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.92251400
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.89776772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.75418898
2MP0003880_abnormal_central_pattern4.17070415
3MP0003635_abnormal_synaptic_transmissio3.34416347
4MP0004270_analgesia3.30333232
5MP0001968_abnormal_touch/_nociception2.81661944
6MP0002063_abnormal_learning/memory/cond2.68158999
7MP0002734_abnormal_mechanical_nocicepti2.64242396
8MP0002064_seizures2.59881935
9MP0009745_abnormal_behavioral_response2.58993631
10MP0002736_abnormal_nociception_after2.47972132
11MP0002735_abnormal_chemical_nociception2.42969937
12MP0001486_abnormal_startle_reflex2.38991783
13MP0002572_abnormal_emotion/affect_behav2.37797470
14MP0002272_abnormal_nervous_system2.33302336
15MP0009046_muscle_twitch2.18103491
16MP0000049_abnormal_middle_ear2.13380885
17MP0005394_taste/olfaction_phenotype2.09416026
18MP0005499_abnormal_olfactory_system2.09416026
19MP0008789_abnormal_olfactory_epithelium2.08897290
20MP0000778_abnormal_nervous_system2.04611105
21MP0006292_abnormal_olfactory_placode1.94227234
22MP0002822_catalepsy1.90594349
23MP0002067_abnormal_sensory_capabilities1.86637974
24MP0005551_abnormal_eye_electrophysiolog1.84299230
25MP0001529_abnormal_vocalization1.83416522
26MP0002653_abnormal_ependyma_morphology1.80903903
27MP0002909_abnormal_adrenal_gland1.76575300
28MP0002184_abnormal_innervation1.75817354
29MP0001984_abnormal_olfaction1.72895326
30MP0001502_abnormal_circadian_rhythm1.71262187
31MP0001970_abnormal_pain_threshold1.70886754
32MP0005423_abnormal_somatic_nervous1.68887485
33MP0002733_abnormal_thermal_nociception1.68029793
34MP0006276_abnormal_autonomic_nervous1.67414709
35MP0001905_abnormal_dopamine_level1.65393444
36MP0000566_synostosis1.60670337
37MP0005623_abnormal_meninges_morphology1.58560487
38MP0001440_abnormal_grooming_behavior1.56133021
39MP0000751_myopathy1.55884294
40MP0003121_genomic_imprinting1.55695904
41MP0002102_abnormal_ear_morphology1.53390723
42MP0004811_abnormal_neuron_physiology1.51724958
43MP0002234_abnormal_pharynx_morphology1.50729728
44MP0008569_lethality_at_weaning1.50267764
45MP0000955_abnormal_spinal_cord1.49905901
46MP0002090_abnormal_vision1.49236189
47MP0005409_darkened_coat_color1.47984032
48MP0004133_heterotaxia1.45644941
49MP0003329_amyloid_beta_deposits1.45094122
50MP0001501_abnormal_sleep_pattern1.44638215
51MP0002233_abnormal_nose_morphology1.44319309
52MP0002837_dystrophic_cardiac_calcinosis1.39793896
53MP0002882_abnormal_neuron_morphology1.38713145
54MP0009780_abnormal_chondrocyte_physiolo1.37167796
55MP0003890_abnormal_embryonic-extraembry1.36429302
56MP0002557_abnormal_social/conspecific_i1.35200982
57MP0004924_abnormal_behavior1.35123358
58MP0005386_behavior/neurological_phenoty1.35123358
59MP0003937_abnormal_limbs/digits/tail_de1.32890150
60MP0001188_hyperpigmentation1.32640363
61MP0003861_abnormal_nervous_system1.29460054
62MP0003633_abnormal_nervous_system1.27943175
63MP0001293_anophthalmia1.27645903
64MP0008438_abnormal_cutaneous_collagen1.26048134
65MP0004885_abnormal_endolymph1.25192441
66MP0003567_abnormal_fetal_cardiomyocyte1.25078629
67MP0002066_abnormal_motor_capabilities/c1.25058841
68MP0001299_abnormal_eye_distance/1.24884009
69MP0003122_maternal_imprinting1.24790868
70MP0004858_abnormal_nervous_system1.24090840
71MP0003938_abnormal_ear_development1.23599555
72MP0002638_abnormal_pupillary_reflex1.22728762
73MP0005171_absent_coat_pigmentation1.21298265
74MP0000537_abnormal_urethra_morphology1.19311076
75MP0006072_abnormal_retinal_apoptosis1.19259488
76MP0003283_abnormal_digestive_organ1.18908967
77MP0000920_abnormal_myelination1.17944983
78MP0003755_abnormal_palate_morphology1.17247752
79MP0004145_abnormal_muscle_electrophysio1.17212293
80MP0003119_abnormal_digestive_system1.16272472
81MP0001346_abnormal_lacrimal_gland1.16089120
82MP0002751_abnormal_autonomic_nervous1.14429441
83MP0003385_abnormal_body_wall1.14425376
84MP0000013_abnormal_adipose_tissue1.14140927
85MP0002697_abnormal_eye_size1.13959079
86MP0000026_abnormal_inner_ear1.13403076
87MP0010030_abnormal_orbit_morphology1.12165455
88MP0003631_nervous_system_phenotype1.11124322
89MP0004233_abnormal_muscle_weight1.07901639
90MP0010386_abnormal_urinary_bladder1.05400529
91MP0005248_abnormal_Harderian_gland1.05141608
92MP0002152_abnormal_brain_morphology1.01121532
93MP0004215_abnormal_myocardial_fiber0.99138756
94MP0002229_neurodegeneration0.98981579
95MP0009379_abnormal_foot_pigmentation0.98674549
96MP0005187_abnormal_penis_morphology0.96912144
97MP0001286_abnormal_eye_development0.95527394
98MP0003632_abnormal_nervous_system0.94948914
99MP0004142_abnormal_muscle_tone0.94472136
100MP0003136_yellow_coat_color0.93043510
101MP0000647_abnormal_sebaceous_gland0.93037012
102MP0003879_abnormal_hair_cell0.92361494
103MP0005167_abnormal_blood-brain_barrier0.91924074
104MP0002295_abnormal_pulmonary_circulatio0.91256722
105MP0002752_abnormal_somatic_nervous0.91172233
106MP0002116_abnormal_craniofacial_bone0.87413147
107MP0005253_abnormal_eye_physiology0.87291149
108MP0000534_abnormal_ureter_morphology0.86636189
109MP0003634_abnormal_glial_cell0.86194036
110MP0004085_abnormal_heartbeat0.86074267
111MP0003942_abnormal_urinary_system0.85582715
112MP0001177_atelectasis0.84511301
113MP0003935_abnormal_craniofacial_develop0.84188800
114MP0008877_abnormal_DNA_methylation0.83528381
115MP0002081_perinatal_lethality0.82431750
116MP0003123_paternal_imprinting0.81771067
117MP0005503_abnormal_tendon_morphology0.81721358
118MP0000631_abnormal_neuroendocrine_gland0.81523422
119MP0004883_abnormal_blood_vessel0.80959660
120MP0004036_abnormal_muscle_relaxation0.80947369
121MP0005195_abnormal_posterior_eye0.80169079
122MP0005391_vision/eye_phenotype0.79698032
123MP0001485_abnormal_pinna_reflex0.74690895
124MP0004742_abnormal_vestibular_system0.73956603
125MP0001963_abnormal_hearing_physiology0.73814153
126MP0002069_abnormal_eating/drinking_beha0.73503939
127MP0003787_abnormal_imprinting0.73017781
128MP0004484_altered_response_of0.71828922
129MP0005595_abnormal_vascular_smooth0.71124648
130MP0001943_abnormal_respiration0.69515139
131MP0005646_abnormal_pituitary_gland0.68849128
132MP0003137_abnormal_impulse_conducting0.67861201
133MP0008874_decreased_physiological_sensi0.66549481
134MP0004272_abnormal_basement_membrane0.66450576
135MP0005535_abnormal_body_temperature0.64110920
136MP0003950_abnormal_plasma_membrane0.62492681

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.01248226
2Focal seizures (HP:0007359)4.93032093
3Atonic seizures (HP:0010819)4.76156472
4Myokymia (HP:0002411)4.74758235
5Epileptic encephalopathy (HP:0200134)4.46415296
6Hepatoblastoma (HP:0002884)4.19689369
7Absence seizures (HP:0002121)3.85246828
8Febrile seizures (HP:0002373)3.83591920
9Progressive cerebellar ataxia (HP:0002073)3.63750171
10Dialeptic seizures (HP:0011146)3.62294824
11Hyperventilation (HP:0002883)3.53616713
12Action tremor (HP:0002345)3.32668398
13Abnormality of the labia minora (HP:0012880)3.30357398
14Gait imbalance (HP:0002141)3.28346547
15Congenital stationary night blindness (HP:0007642)3.24273836
16Generalized tonic-clonic seizures (HP:0002069)3.18068565
17Visual hallucinations (HP:0002367)3.07619420
18Medial flaring of the eyebrow (HP:0010747)2.92953884
19Congenital primary aphakia (HP:0007707)2.91280967
20Cortical dysplasia (HP:0002539)2.89252892
21Retinal dysplasia (HP:0007973)2.81893810
22Dysmetria (HP:0001310)2.80775331
23Hydroureter (HP:0000072)2.80094043
24Nephrogenic diabetes insipidus (HP:0009806)2.72248691
25Truncal ataxia (HP:0002078)2.68135077
26Abnormality of the lower motor neuron (HP:0002366)2.68093615
27Hemiparesis (HP:0001269)2.67937197
28Broad-based gait (HP:0002136)2.66961188
29Amyotrophic lateral sclerosis (HP:0007354)2.66911977
30Vaginal atresia (HP:0000148)2.62798001
31Buphthalmos (HP:0000557)2.62229555
32Gaze-evoked nystagmus (HP:0000640)2.60483323
33Dysdiadochokinesis (HP:0002075)2.59716210
34Amblyopia (HP:0000646)2.58319451
35Genital tract atresia (HP:0001827)2.56204478
36Scanning speech (HP:0002168)2.55030610
37Excessive salivation (HP:0003781)2.54746652
38Drooling (HP:0002307)2.54746652
39Epileptiform EEG discharges (HP:0011182)2.53803632
40Urinary bladder sphincter dysfunction (HP:0002839)2.53217446
41Lissencephaly (HP:0001339)2.49624325
42Termporal pattern (HP:0011008)2.49481391
43Insidious onset (HP:0003587)2.49481391
44Abnormality of macular pigmentation (HP:0008002)2.48345724
45Spastic gait (HP:0002064)2.47841365
46Mutism (HP:0002300)2.46887604
47Type II lissencephaly (HP:0007260)2.43216256
48Ankle clonus (HP:0011448)2.38747515
49EEG with generalized epileptiform discharges (HP:0011198)2.38010551
50Abnormality of the corticospinal tract (HP:0002492)2.37591659
51Pachygyria (HP:0001302)2.35003217
52Poor coordination (HP:0002370)2.34059296
53Nephronophthisis (HP:0000090)2.33112507
54True hermaphroditism (HP:0010459)2.32315388
55Depression (HP:0000716)2.31459799
56Specific learning disability (HP:0001328)2.31407252
57Polyphagia (HP:0002591)2.28183727
58Central scotoma (HP:0000603)2.27755912
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.26659875
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26659875
61Vitreoretinal degeneration (HP:0000655)2.23575227
62Abnormality of midbrain morphology (HP:0002418)2.22558792
63Molar tooth sign on MRI (HP:0002419)2.22558792
64Supranuclear gaze palsy (HP:0000605)2.22554372
65Hypoventilation (HP:0002791)2.22235988
66Pancreatic fibrosis (HP:0100732)2.22145170
67Absent speech (HP:0001344)2.21423129
68Urinary urgency (HP:0000012)2.20389008
69Occipital encephalocele (HP:0002085)2.15801041
70Hypsarrhythmia (HP:0002521)2.15116368
71Cerebral inclusion bodies (HP:0100314)2.14799480
72Neurofibrillary tangles (HP:0002185)2.14458517
73Postaxial hand polydactyly (HP:0001162)2.12389549
74Narrow nasal bridge (HP:0000446)2.12041398
75Impaired vibration sensation in the lower limbs (HP:0002166)2.11884499
76Torticollis (HP:0000473)2.08739457
77Premature rupture of membranes (HP:0001788)2.07553641
78Broad alveolar ridges (HP:0000187)2.04767985
79Aplasia involving bones of the upper limbs (HP:0009823)2.04069694
80Aplasia of the phalanges of the hand (HP:0009802)2.04069694
81Aplasia involving bones of the extremities (HP:0009825)2.04069694
82Limb dystonia (HP:0002451)2.03294272
83Shallow orbits (HP:0000586)2.02134405
84Failure to thrive in infancy (HP:0001531)2.01317699
85Anxiety (HP:0000739)2.00809098
86Protrusio acetabuli (HP:0003179)1.99530002
87Blue irides (HP:0000635)1.99179837
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98808144
89Pancreatic cysts (HP:0001737)1.97904698
90Anophthalmia (HP:0000528)1.96997698
91Choroideremia (HP:0001139)1.95708820
92Septo-optic dysplasia (HP:0100842)1.95417546
93Split foot (HP:0001839)1.95388884
94Pheochromocytoma (HP:0002666)1.95250318
95Optic nerve hypoplasia (HP:0000609)1.95018347
96Broad foot (HP:0001769)1.94739467
97Stenosis of the external auditory canal (HP:0000402)1.93422679
98Short 4th metacarpal (HP:0010044)1.92243383
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92243383
100Poor eye contact (HP:0000817)1.91767485
101Micropenis (HP:0000054)1.91737526
102Colon cancer (HP:0003003)1.91613428
103Increased variability in muscle fiber diameter (HP:0003557)1.91612802
104Onion bulb formation (HP:0003383)1.89175396
105Impaired social interactions (HP:0000735)1.88836359
106Abnormal social behavior (HP:0012433)1.88836359
107Labial hypoplasia (HP:0000066)1.88769414
108Abnormal eating behavior (HP:0100738)1.86158589
109Spastic tetraplegia (HP:0002510)1.86052069
110Decreased central vision (HP:0007663)1.85484627
111Decreased testicular size (HP:0008734)1.85280756
112Aqueductal stenosis (HP:0002410)1.85164742
113Intestinal atresia (HP:0011100)1.85137937
114Genetic anticipation (HP:0003743)1.84816800
115Intention tremor (HP:0002080)1.84234271
116Focal dystonia (HP:0004373)1.84168432
117Aplasia/Hypoplasia of the lens (HP:0008063)1.84019521
118Lower limb amyotrophy (HP:0007210)1.83752068
119Cerebellar dysplasia (HP:0007033)1.83525333
120Narrow forehead (HP:0000341)1.83063534
121Atrophy/Degeneration involving motor neurons (HP:0007373)1.82362104
122Diplopia (HP:0000651)1.81965377
123Abnormality of binocular vision (HP:0011514)1.81965377
124Anencephaly (HP:0002323)1.81959847
125Postural tremor (HP:0002174)1.81198666
126Papilledema (HP:0001085)1.81147479
127Morphological abnormality of the pyramidal tract (HP:0002062)1.80801047
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.80297543
129Chronic hepatic failure (HP:0100626)1.79365306
130Sclerocornea (HP:0000647)1.77024642
131Shoulder girdle muscle weakness (HP:0003547)1.76437458
132Abnormality of the renal medulla (HP:0100957)1.75685417
133Lower limb muscle weakness (HP:0007340)1.75515967
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75255051
135Abnormal hair whorl (HP:0010721)1.74893392
136Hypoplasia of the corpus callosum (HP:0002079)1.74246256
137Abnormality of the intervertebral disk (HP:0005108)1.73947263
138Renal hypoplasia (HP:0000089)1.72818356
139Megalencephaly (HP:0001355)1.70895825
140Lower limb asymmetry (HP:0100559)1.70796438
141Neoplasm of the heart (HP:0100544)1.70782008
142Stereotypic behavior (HP:0000733)1.70603561
143Abnormality of salivation (HP:0100755)1.70469940
144Status epilepticus (HP:0002133)1.70082818
145Open mouth (HP:0000194)1.69450787
146Dysmetric saccades (HP:0000641)1.69370034
147Rib fusion (HP:0000902)1.68968798
148Generalized myoclonic seizures (HP:0002123)1.67718285
149Difficulty running (HP:0009046)1.67627844
150Resting tremor (HP:0002322)1.67014553
151Prolonged QT interval (HP:0001657)1.66947525
152Hyperglycinemia (HP:0002154)1.66844536
153Agitation (HP:0000713)1.66822740
154Thickened helices (HP:0000391)1.66505725
155Cutaneous finger syndactyly (HP:0010554)1.66465660
156Anterior segment dysgenesis (HP:0007700)1.66351318
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66093261
158Hypoplasia of the brainstem (HP:0002365)1.66093261
159Inability to walk (HP:0002540)1.65763518
160Abnormality of the metopic suture (HP:0005556)1.65636625
161Abnormality of the 4th metacarpal (HP:0010012)1.65385606
162Oligodactyly (hands) (HP:0001180)1.64796660
163Exotropia (HP:0000577)1.64319248
164Scotoma (HP:0000575)1.64107183
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63824669
166Impaired smooth pursuit (HP:0007772)1.63685319
167Postural instability (HP:0002172)1.63462874
168Craniofacial dystonia (HP:0012179)1.62005271
169Anteriorly placed anus (HP:0001545)1.61453077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.33804308
2NTRK33.28316276
3EPHA42.88699149
4MARK12.73505698
5MAP3K42.62876238
6CDK192.35301976
7WNK32.25013945
8DYRK22.18853992
9MAP2K72.13846623
10MAP3K122.12804517
11DAPK22.10658986
12NTRK22.09108459
13PINK12.06188314
14MINK11.92604416
15TRIM281.86867362
16PAK61.85047823
17OXSR11.81282717
18DYRK31.81045549
19AKT31.77920949
20PNCK1.76029470
21MAP3K91.71988944
22MAP4K21.68046579
23MAP2K41.66355697
24NTRK11.66037053
25EPHB21.65894829
26EPHA31.61743703
27PTK2B1.56020463
28CDK51.50317402
29UHMK11.49926036
30PLK21.45919467
31DDR21.42567269
32INSRR1.40806423
33CSNK1G21.40054223
34STK38L1.36912891
35PAK31.32587693
36KSR11.29276880
37KSR21.26521698
38FGFR21.23259438
39PRPF4B1.21207008
40RIPK41.20570880
41SIK21.18065314
42FER1.17585392
43PRKD31.17262759
44CSNK1A1L1.15287718
45CAMK2B1.15152142
46RPS6KA41.14836125
47CAMK2A1.14646794
48TIE11.13855356
49STK391.12183270
50MAPK131.11170179
51SRPK11.07660074
52DYRK1B1.07624200
53WNK11.06538666
54SGK4941.04290485
55SGK2231.04290485
56FRK1.03836696
57CSNK1G31.02827054
58BCR1.01190022
59PHKG11.00810448
60PHKG21.00810448
61CDK141.00727914
62CDK180.98105842
63TNIK0.98059536
64CAMKK10.95682411
65LATS20.95338414
66CDK150.94741867
67MAPKAPK50.92898797
68PRKCG0.90132192
69GRK70.89361999
70STK110.89119169
71MAP3K60.87281085
72CAMKK20.84575705
73CAMK1G0.83983379
74ROCK20.83574687
75CDK11A0.82714342
76FES0.82576778
77TYRO30.82549448
78PRKCE0.80951949
79GRK50.79968763
80RET0.79937219
81FGR0.79737591
82BCKDK0.79029447
83CAMK2D0.78578985
84MAP3K70.75529468
85STK380.72614939
86MAP2K10.71060778
87CAMK40.70841475
88DAPK10.70635098
89PDGFRA0.69767802
90WNK40.68918124
91MAP3K20.68026921
92CAMK1D0.67588488
93PRKCH0.67455866
94ERBB20.66480012
95ERBB30.65950287
96BRD40.65778944
97MKNK10.65524213
98CSNK1G10.65174989
99SIK30.64610983
100DMPK0.63322044
101NME10.62647607
102MARK20.61780203
103PRKD10.61368493
104SGK30.55690598
105RPS6KA20.53791070
106PIK3CA0.53604642
107SIK10.53231539
108CAMK10.51185724
109LIMK10.50727838
110FYN0.49842412
111MAPK100.48417507
112PRKG10.47591724
113SGK20.47184491
114ADRBK10.47174702
115PRKCZ0.47060715
116RIPK10.46046386
117SGK10.44989291
118ADRBK20.44949209
119CSNK1D0.44296801
120DYRK1A0.43774535
121PRKACA0.43741324
122MKNK20.43394159
123MAP3K10.42933873
124PRKAA10.42093164
125PKN10.41786604
126ROCK10.41151445
127SRC0.41142797
128CSNK1E0.40924670
129STK30.40549762
130NEK10.40288697
131CSNK1A10.39124419
132CAMK2G0.39111226
133FGFR10.38774805
134RPS6KA30.38270065
135PRKACB0.33302931
136MAPK90.30482154
137PRKDC0.29762409
138GRK10.28649547
139BMPR1B0.27045303

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57808738
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65367506
3GABAergic synapse_Homo sapiens_hsa047272.59473735
4Synaptic vesicle cycle_Homo sapiens_hsa047212.55669565
5Circadian entrainment_Homo sapiens_hsa047132.52376562
6Glutamatergic synapse_Homo sapiens_hsa047242.51300004
7Morphine addiction_Homo sapiens_hsa050322.30141966
8Long-term potentiation_Homo sapiens_hsa047202.09578312
9Amphetamine addiction_Homo sapiens_hsa050312.06876129
10Dopaminergic synapse_Homo sapiens_hsa047282.00710549
11Insulin secretion_Homo sapiens_hsa049111.99256627
12Salivary secretion_Homo sapiens_hsa049701.89852416
13Serotonergic synapse_Homo sapiens_hsa047261.86353716
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86084156
15Cholinergic synapse_Homo sapiens_hsa047251.77775497
16Steroid biosynthesis_Homo sapiens_hsa001001.75698833
17Olfactory transduction_Homo sapiens_hsa047401.74061838
18Renin secretion_Homo sapiens_hsa049241.73093956
19Long-term depression_Homo sapiens_hsa047301.72042181
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70420527
21Cocaine addiction_Homo sapiens_hsa050301.60626360
22Axon guidance_Homo sapiens_hsa043601.56367166
23Oxytocin signaling pathway_Homo sapiens_hsa049211.52520213
24Taste transduction_Homo sapiens_hsa047421.49768799
25Gap junction_Homo sapiens_hsa045401.48369744
26Gastric acid secretion_Homo sapiens_hsa049711.45453783
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45083108
28GnRH signaling pathway_Homo sapiens_hsa049121.42940872
29Phototransduction_Homo sapiens_hsa047441.42839133
30Collecting duct acid secretion_Homo sapiens_hsa049661.39628484
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38423988
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36794279
33Protein export_Homo sapiens_hsa030601.34270936
34Calcium signaling pathway_Homo sapiens_hsa040201.31544710
35Cardiac muscle contraction_Homo sapiens_hsa042601.30734598
36Hippo signaling pathway_Homo sapiens_hsa043901.28581624
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28194466
38Basal cell carcinoma_Homo sapiens_hsa052171.26541815
39Vibrio cholerae infection_Homo sapiens_hsa051101.25704499
40Oxidative phosphorylation_Homo sapiens_hsa001901.15382457
41Estrogen signaling pathway_Homo sapiens_hsa049151.13483240
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12205141
43Alzheimers disease_Homo sapiens_hsa050101.11579130
44Melanogenesis_Homo sapiens_hsa049161.06990652
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05877891
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03519707
47Glioma_Homo sapiens_hsa052141.03142153
48cAMP signaling pathway_Homo sapiens_hsa040241.02867821
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02223795
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.02147106
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00946588
52Type II diabetes mellitus_Homo sapiens_hsa049301.00929255
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00445962
54Dilated cardiomyopathy_Homo sapiens_hsa054140.99734087
55ErbB signaling pathway_Homo sapiens_hsa040120.97942148
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97767533
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95666871
58Propanoate metabolism_Homo sapiens_hsa006400.90700583
59Nitrogen metabolism_Homo sapiens_hsa009100.85374140
60Butanoate metabolism_Homo sapiens_hsa006500.85290008
61Dorso-ventral axis formation_Homo sapiens_hsa043200.84448803
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84216184
63Parkinsons disease_Homo sapiens_hsa050120.83596770
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81947901
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.80547403
66Pancreatic secretion_Homo sapiens_hsa049720.80538173
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80005493
68Renal cell carcinoma_Homo sapiens_hsa052110.79443219
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79210946
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78153680
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75993734
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75885290
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74861612
74Thyroid hormone synthesis_Homo sapiens_hsa049180.74186981
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72018986
76MAPK signaling pathway_Homo sapiens_hsa040100.70966316
77Ras signaling pathway_Homo sapiens_hsa040140.66317908
78Choline metabolism in cancer_Homo sapiens_hsa052310.65416527
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65316830
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63812175
81AMPK signaling pathway_Homo sapiens_hsa041520.63002415
82Basal transcription factors_Homo sapiens_hsa030220.62525498
83Notch signaling pathway_Homo sapiens_hsa043300.61180869
84Rap1 signaling pathway_Homo sapiens_hsa040150.58525283
85Wnt signaling pathway_Homo sapiens_hsa043100.57963403
86Fatty acid elongation_Homo sapiens_hsa000620.57305139
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56321817
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.54310486
89Glucagon signaling pathway_Homo sapiens_hsa049220.54198329
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54104471
91Huntingtons disease_Homo sapiens_hsa050160.53715201
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53539261
93VEGF signaling pathway_Homo sapiens_hsa043700.52695911
94Colorectal cancer_Homo sapiens_hsa052100.51771315
95Ovarian steroidogenesis_Homo sapiens_hsa049130.51299077
96Fatty acid biosynthesis_Homo sapiens_hsa000610.51084688
97Alcoholism_Homo sapiens_hsa050340.50710316
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50504019
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50494986
100Bile secretion_Homo sapiens_hsa049760.49817798
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47589902
102African trypanosomiasis_Homo sapiens_hsa051430.46486657
103Adherens junction_Homo sapiens_hsa045200.46407162
104Circadian rhythm_Homo sapiens_hsa047100.45977143
105mRNA surveillance pathway_Homo sapiens_hsa030150.44973381
106Biosynthesis of amino acids_Homo sapiens_hsa012300.44747865
107Focal adhesion_Homo sapiens_hsa045100.44563859
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43722643
109TGF-beta signaling pathway_Homo sapiens_hsa043500.42742652
110Oocyte meiosis_Homo sapiens_hsa041140.42432004
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41875303
112Mineral absorption_Homo sapiens_hsa049780.41020790
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40346544
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39954530
115Regulation of autophagy_Homo sapiens_hsa041400.39190646
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38521598
117RNA polymerase_Homo sapiens_hsa030200.38489834
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38070277
119Inositol phosphate metabolism_Homo sapiens_hsa005620.37807512
120Ether lipid metabolism_Homo sapiens_hsa005650.37537369
121mTOR signaling pathway_Homo sapiens_hsa041500.37397657
122ECM-receptor interaction_Homo sapiens_hsa045120.37022108
123Protein digestion and absorption_Homo sapiens_hsa049740.36591481
124RNA degradation_Homo sapiens_hsa030180.36337353
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35592026
126Hedgehog signaling pathway_Homo sapiens_hsa043400.35417732
127Endometrial cancer_Homo sapiens_hsa052130.35348294
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34805249
129Tight junction_Homo sapiens_hsa045300.34756887
130Phagosome_Homo sapiens_hsa041450.33568722
131Endocytosis_Homo sapiens_hsa041440.33357981
132Pyruvate metabolism_Homo sapiens_hsa006200.32065091

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