PCDHB16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.49562119
2neuron cell-cell adhesion (GO:0007158)4.81502443
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52090887
4protein localization to synapse (GO:0035418)4.34856980
5G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.32874668
6presynaptic membrane assembly (GO:0097105)3.98018558
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97381568
8nonmotile primary cilium assembly (GO:0035058)3.96232985
9synaptic vesicle exocytosis (GO:0016079)3.95943959
10gamma-aminobutyric acid signaling pathway (GO:0007214)3.90153291
11pyrimidine nucleobase catabolic process (GO:0006208)3.89005330
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.88791465
13glutamate receptor signaling pathway (GO:0007215)3.88217410
14regulation of synaptic vesicle exocytosis (GO:2000300)3.83627898
15relaxation of smooth muscle (GO:0044557)3.82054121
16detection of light stimulus involved in visual perception (GO:0050908)3.79263276
17detection of light stimulus involved in sensory perception (GO:0050962)3.79263276
18postsynaptic membrane organization (GO:0001941)3.78233548
19striatum development (GO:0021756)3.70794976
20neurotransmitter-gated ion channel clustering (GO:0072578)3.70581019
21neuron recognition (GO:0008038)3.67339434
22gamma-aminobutyric acid transport (GO:0015812)3.66574244
23dendritic spine morphogenesis (GO:0060997)3.64902425
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62948641
25negative regulation of cytosolic calcium ion concentration (GO:0051481)3.62541521
26positive regulation of synapse maturation (GO:0090129)3.61940346
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.60088266
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56052712
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.52345978
30transmission of nerve impulse (GO:0019226)3.48332807
31presynaptic membrane organization (GO:0097090)3.46740446
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.45051310
33innervation (GO:0060384)3.40053958
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39403000
35regulation of synapse structural plasticity (GO:0051823)3.36137570
36central nervous system projection neuron axonogenesis (GO:0021952)3.33984683
37protein polyglutamylation (GO:0018095)3.33493500
38* synapse assembly (GO:0007416)3.33248207
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31278471
40cell communication by electrical coupling (GO:0010644)3.30616513
41synaptic vesicle endocytosis (GO:0048488)3.30284078
42layer formation in cerebral cortex (GO:0021819)3.28338702
43head development (GO:0060322)3.27649861
44dendrite morphogenesis (GO:0048813)3.25599925
45nucleobase catabolic process (GO:0046113)3.25202666
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.24936576
47neuron-neuron synaptic transmission (GO:0007270)3.23549691
48regulation of glutamate receptor signaling pathway (GO:1900449)3.22713213
49regulation of synaptic vesicle transport (GO:1902803)3.22432784
50synaptic vesicle maturation (GO:0016188)3.22356283
51behavioral response to ethanol (GO:0048149)3.21548445
52establishment of nucleus localization (GO:0040023)3.14696902
53cerebellar granule cell differentiation (GO:0021707)3.13786961
54cerebellar Purkinje cell differentiation (GO:0021702)3.13339540
55synaptic transmission, glutamatergic (GO:0035249)3.12108288
56axonal fasciculation (GO:0007413)3.11629804
57startle response (GO:0001964)3.10894445
58regulation of synapse maturation (GO:0090128)3.10786059
59intraciliary transport (GO:0042073)3.10296592
60regulation of cilium movement (GO:0003352)3.08557465
61cilium morphogenesis (GO:0060271)3.06915527
62neurotransmitter secretion (GO:0007269)3.06737351
63retinal rod cell development (GO:0046548)3.04699226
64cell migration in hindbrain (GO:0021535)3.02472772
65long-term synaptic potentiation (GO:0060291)3.01771751
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00642774
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99022169
68cellular potassium ion homeostasis (GO:0030007)2.98814904
69epithelial cilium movement (GO:0003351)2.98712991
70axoneme assembly (GO:0035082)2.98214099
71photoreceptor cell maintenance (GO:0045494)2.97207692
72negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96676213
73prepulse inhibition (GO:0060134)2.94891956
74glutamate secretion (GO:0014047)2.92441433
75mating behavior (GO:0007617)2.92416534
76cerebellar Purkinje cell layer development (GO:0021680)2.91434961
77protein localization to cilium (GO:0061512)2.88276805
78peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.87957325
79L-fucose catabolic process (GO:0042355)2.87562213
80fucose catabolic process (GO:0019317)2.87562213
81L-fucose metabolic process (GO:0042354)2.87562213
82regulation of postsynaptic membrane potential (GO:0060078)2.87186434
83inositol phosphate catabolic process (GO:0071545)2.85020470
84dendrite development (GO:0016358)2.84770912
85sodium ion export (GO:0071436)2.84035164
86regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84025745
87glycerophospholipid catabolic process (GO:0046475)2.83522179
88regulation of neuronal synaptic plasticity (GO:0048168)2.82701028
89response to pheromone (GO:0019236)2.82611224
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81809807
91regulation of neurotransmitter secretion (GO:0046928)2.81754049
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81627494
93regulation of synapse assembly (GO:0051963)2.80481461
94membrane depolarization during action potential (GO:0086010)2.80415152
95positive regulation of synapse assembly (GO:0051965)2.80409254
96cellular ketone body metabolic process (GO:0046950)2.79701095
97* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.78396789
98locomotory exploration behavior (GO:0035641)2.78379124
99behavioral defense response (GO:0002209)2.77938178
100behavioral fear response (GO:0001662)2.77938178
101cornea development in camera-type eye (GO:0061303)2.77531885
102response to histamine (GO:0034776)2.77348259
103cerebral cortex radially oriented cell migration (GO:0021799)2.76802045
104neuronal ion channel clustering (GO:0045161)2.76136400
105central nervous system neuron axonogenesis (GO:0021955)2.76025452
106* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.75353233
107synaptic transmission, cholinergic (GO:0007271)2.75053671
108membrane hyperpolarization (GO:0060081)2.74487845
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73520302
110limb bud formation (GO:0060174)2.73382436
111water-soluble vitamin biosynthetic process (GO:0042364)2.73335542
112retinal ganglion cell axon guidance (GO:0031290)2.73308849
113cilium organization (GO:0044782)2.72976135
114* synapse organization (GO:0050808)2.69929472
115cilium assembly (GO:0042384)2.69770548
116tachykinin receptor signaling pathway (GO:0007217)2.69344396
117neuronal action potential (GO:0019228)2.69094578
118platelet dense granule organization (GO:0060155)2.69072912
119exploration behavior (GO:0035640)2.68090948
120positive regulation of mitochondrial fission (GO:0090141)2.67200009
121dendritic spine organization (GO:0097061)2.66660632
122behavioral response to nicotine (GO:0035095)2.65218736
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64718968
124reflex (GO:0060004)2.62471433
125learning (GO:0007612)2.62383631
126auditory behavior (GO:0031223)2.62320355
127adaptation of signaling pathway (GO:0023058)2.61247838
128proline transport (GO:0015824)2.59854895
129synaptic vesicle transport (GO:0048489)2.59371760
130establishment of synaptic vesicle localization (GO:0097480)2.59371760
131kidney morphogenesis (GO:0060993)2.58925511
132regulation of neurotransmitter transport (GO:0051588)2.58856095
133regulation of synapse organization (GO:0050807)2.58009992
134auditory receptor cell differentiation (GO:0042491)2.57719065
135regulation of neurotransmitter uptake (GO:0051580)2.57561423
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57399808
137long term synaptic depression (GO:0060292)2.56907127
138neurotransmitter transport (GO:0006836)2.56670504
139neuronal action potential propagation (GO:0019227)2.56574738
140fear response (GO:0042596)2.56166891
141cilium movement (GO:0003341)2.55658468
142regulation of action potential (GO:0098900)2.53828066
143glycosphingolipid biosynthetic process (GO:0006688)2.53646108
144inner ear receptor stereocilium organization (GO:0060122)2.53412666
145neural tube formation (GO:0001841)2.52544312
146regulation of microtubule-based movement (GO:0060632)2.51743420
147indolalkylamine metabolic process (GO:0006586)2.51030924
148ketone body metabolic process (GO:1902224)2.47159949
149kynurenine metabolic process (GO:0070189)2.46310621
150adult feeding behavior (GO:0008343)2.44901805
151regulation of feeding behavior (GO:0060259)2.44517267
152tryptophan catabolic process (GO:0006569)2.42023656
153indole-containing compound catabolic process (GO:0042436)2.42023656
154indolalkylamine catabolic process (GO:0046218)2.42023656
155negative regulation of axon guidance (GO:1902668)2.38649839
156neuromuscular synaptic transmission (GO:0007274)2.38052577
157peristalsis (GO:0030432)2.35916832
158somite development (GO:0061053)2.34991110
159sympathetic nervous system development (GO:0048485)2.34828410
160brain morphogenesis (GO:0048854)2.33312019
161negative regulation of telomere maintenance (GO:0032205)2.32776264
162appendage development (GO:0048736)2.31627532
163limb development (GO:0060173)2.31627532
164positive regulation of growth hormone secretion (GO:0060124)2.30213108
165retinal cone cell development (GO:0046549)2.30210593
166phosphorylated carbohydrate dephosphorylation (GO:0046838)2.29598394
167inositol phosphate dephosphorylation (GO:0046855)2.29598394
168ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.28867060
169righting reflex (GO:0060013)2.24364779
170regulation of axon guidance (GO:1902667)2.23837992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13680180
2GBX2_23144817_ChIP-Seq_PC3_Human4.29783371
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68011653
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64141494
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60797073
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59376778
7VDR_22108803_ChIP-Seq_LS180_Human2.48485013
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40177363
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36304896
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36304896
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.36212907
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36036198
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.31632589
14IGF1R_20145208_ChIP-Seq_DFB_Human2.22723735
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22332937
16TAF15_26573619_Chip-Seq_HEK293_Human2.22058475
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12913965
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08602931
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07514443
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04859823
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03542259
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.03427054
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00971524
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98694606
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.97305827
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.93425416
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90933974
28DROSHA_22980978_ChIP-Seq_HELA_Human1.89585936
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.87579004
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86635424
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84986897
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82274463
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82082010
34REST_21632747_ChIP-Seq_MESCs_Mouse1.80069435
35SMAD4_21799915_ChIP-Seq_A2780_Human1.79372687
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76840152
37AR_21572438_ChIP-Seq_LNCaP_Human1.76343511
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.74668972
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.72076755
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69431607
41P300_19829295_ChIP-Seq_ESCs_Human1.68494809
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63206499
43FUS_26573619_Chip-Seq_HEK293_Human1.61764137
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61651257
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60000621
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.58572244
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55195670
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53717441
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51419930
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.48908322
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48464653
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48381017
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46720088
54CBP_20019798_ChIP-Seq_JUKART_Human1.43903356
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43903356
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43410519
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42750488
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41570123
59AR_25329375_ChIP-Seq_VCAP_Human1.39692325
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39590609
61RNF2_27304074_Chip-Seq_NSC_Mouse1.39155384
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39153952
63STAT3_23295773_ChIP-Seq_U87_Human1.34352316
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.34024127
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33150972
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30192447
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.29628710
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29421746
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28827892
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28245434
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28009196
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27996608
73IRF1_19129219_ChIP-ChIP_H3396_Human1.27370441
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.26850687
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.26191408
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25929378
77TP53_18474530_ChIP-ChIP_U2OS_Human1.25840017
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25519708
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25489070
80AHR_22903824_ChIP-Seq_MCF-7_Human1.24607757
81TP53_22573176_ChIP-Seq_HFKS_Human1.23353532
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22849179
83TCF4_22108803_ChIP-Seq_LS180_Human1.22793618
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21555000
85TCF4_23295773_ChIP-Seq_U87_Human1.21029642
86AR_19668381_ChIP-Seq_PC3_Human1.19705685
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19529808
88ER_23166858_ChIP-Seq_MCF-7_Human1.18774652
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18577161
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17924205
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.17158423
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.16988685
93BCAT_22108803_ChIP-Seq_LS180_Human1.16610027
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.16186483
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15698605
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15698605
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14461680
98RUNX2_22187159_ChIP-Seq_PCA_Human1.13541158
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13378337
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13194387
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.12631709
102NANOG_19829295_ChIP-Seq_ESCs_Human1.10785235
103SOX2_19829295_ChIP-Seq_ESCs_Human1.10785235
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10341596
105ZNF274_21170338_ChIP-Seq_K562_Hela1.09644189
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09064605
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.08819599
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08810719
109P53_22387025_ChIP-Seq_ESCs_Mouse1.07344284
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06791699
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06767497
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06474166
113JUN_21703547_ChIP-Seq_K562_Human1.04572046
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.04054692
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.03637756
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.03118461
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02236410
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01605212
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01598866
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01528462
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.01257509
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.01044919
123TP53_16413492_ChIP-PET_HCT116_Human0.99947194
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97370199
125EWS_26573619_Chip-Seq_HEK293_Human0.97316353
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96398171
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.95682148
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.95489324
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94274741
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94242806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.69358948
2MP0004859_abnormal_synaptic_plasticity3.68839413
3MP0003635_abnormal_synaptic_transmissio3.02654403
4MP0005551_abnormal_eye_electrophysiolog2.89320942
5MP0002063_abnormal_learning/memory/cond2.58325760
6MP0009745_abnormal_behavioral_response2.51676503
7MP0001501_abnormal_sleep_pattern2.44265341
8MP0001984_abnormal_olfaction2.42530168
9MP0001188_hyperpigmentation2.29914011
10MP0004270_analgesia2.29790013
11MP0001486_abnormal_startle_reflex2.25449164
12MP0002064_seizures2.25416838
13MP0010386_abnormal_urinary_bladder2.22965506
14MP0005423_abnormal_somatic_nervous2.20579876
15MP0001968_abnormal_touch/_nociception2.17366372
16MP0001440_abnormal_grooming_behavior2.16518368
17MP0009780_abnormal_chondrocyte_physiolo2.15584574
18MP0002734_abnormal_mechanical_nocicepti2.10965555
19MP0002572_abnormal_emotion/affect_behav2.09509177
20MP0009046_muscle_twitch2.08800615
21MP0002272_abnormal_nervous_system2.04595522
22MP0006072_abnormal_retinal_apoptosis2.02812505
23MP0002184_abnormal_innervation2.01735410
24MP0003136_yellow_coat_color1.99029660
25MP0000569_abnormal_digit_pigmentation1.96536135
26MP0000778_abnormal_nervous_system1.92703191
27MP0002067_abnormal_sensory_capabilities1.83996807
28MP0006276_abnormal_autonomic_nervous1.82352604
29MP0001502_abnormal_circadian_rhythm1.81295266
30MP0002090_abnormal_vision1.80950980
31MP0004142_abnormal_muscle_tone1.79782308
32MP0008877_abnormal_DNA_methylation1.74638884
33MP0003121_genomic_imprinting1.72432318
34MP0002876_abnormal_thyroid_physiology1.72082124
35MP0002557_abnormal_social/conspecific_i1.71041937
36MP0002938_white_spotting1.70883170
37MP0004133_heterotaxia1.67574743
38MP0003787_abnormal_imprinting1.65760504
39MP0002736_abnormal_nociception_after1.64520052
40MP0005646_abnormal_pituitary_gland1.63965341
41MP0002638_abnormal_pupillary_reflex1.62313064
42MP0002837_dystrophic_cardiac_calcinosis1.61766764
43MP0005503_abnormal_tendon_morphology1.61684511
44MP0003195_calcinosis1.58404410
45MP0002735_abnormal_chemical_nociception1.54665568
46MP0006292_abnormal_olfactory_placode1.50580159
47MP0005645_abnormal_hypothalamus_physiol1.47982198
48MP0008438_abnormal_cutaneous_collagen1.45698264
49MP0004742_abnormal_vestibular_system1.45062075
50MP0005171_absent_coat_pigmentation1.42082374
51MP0001986_abnormal_taste_sensitivity1.41683329
52MP0004811_abnormal_neuron_physiology1.39997128
53MP0005386_behavior/neurological_phenoty1.39839662
54MP0004924_abnormal_behavior1.39839662
55MP0004233_abnormal_muscle_weight1.39682834
56MP0005253_abnormal_eye_physiology1.38325033
57MP0002822_catalepsy1.38180278
58MP0002882_abnormal_neuron_morphology1.35385564
59MP0000427_abnormal_hair_cycle1.34397329
60MP0002653_abnormal_ependyma_morphology1.31871853
61MP0008569_lethality_at_weaning1.31087408
62MP0001970_abnormal_pain_threshold1.28254900
63MP0001177_atelectasis1.27891725
64MP0004043_abnormal_pH_regulation1.25395268
65MP0000631_abnormal_neuroendocrine_gland1.23555750
66MP0000372_irregular_coat_pigmentation1.22981021
67MP0005623_abnormal_meninges_morphology1.18663114
68MP0001299_abnormal_eye_distance/1.16738727
69MP0000955_abnormal_spinal_cord1.16683669
70MP0005195_abnormal_posterior_eye1.16128698
71MP0008775_abnormal_heart_ventricle1.13712734
72MP0005379_endocrine/exocrine_gland_phen1.13547882
73MP0005248_abnormal_Harderian_gland1.13359601
74MP0002752_abnormal_somatic_nervous1.11532425
75MP0005084_abnormal_gallbladder_morpholo1.11497316
76MP0010030_abnormal_orbit_morphology1.10051564
77MP0002733_abnormal_thermal_nociception1.09771947
78MP0008872_abnormal_physiological_respon1.05812110
79MP0002234_abnormal_pharynx_morphology1.05157889
80MP0002066_abnormal_motor_capabilities/c1.02950541
81MP0002254_reproductive_system_inflammat1.02687282
82MP0000751_myopathy1.01190426
83MP0001485_abnormal_pinna_reflex1.00799375
84MP0004147_increased_porphyrin_level0.99580858
85MP0009250_abnormal_appendicular_skeleto0.99253319
86MP0008789_abnormal_olfactory_epithelium0.98414417
87MP0002152_abnormal_brain_morphology0.98280328
88MP0003122_maternal_imprinting0.98005336
89MP0002928_abnormal_bile_duct0.96978908
90MP0000516_abnormal_urinary_system0.96482041
91MP0005367_renal/urinary_system_phenotyp0.96482041
92MP0002108_abnormal_muscle_morphology0.96354241
93MP0002160_abnormal_reproductive_system0.94625733
94MP0001963_abnormal_hearing_physiology0.94521949
95MP0004215_abnormal_myocardial_fiber0.94491918
96MP0000647_abnormal_sebaceous_gland0.94393775
97MP0005394_taste/olfaction_phenotype0.94203079
98MP0005499_abnormal_olfactory_system0.94203079
99MP0002229_neurodegeneration0.92757733
100MP0003646_muscle_fatigue0.91523517
101MP0001529_abnormal_vocalization0.91220720
102MP0002163_abnormal_gland_morphology0.90770802
103MP0003385_abnormal_body_wall0.89843864
104MP0001905_abnormal_dopamine_level0.89246564
105MP0004134_abnormal_chest_morphology0.88983642
106MP0003879_abnormal_hair_cell0.88707691
107MP0003011_delayed_dark_adaptation0.88366853
108MP0004885_abnormal_endolymph0.87983860
109MP0004085_abnormal_heartbeat0.85529335
110MP0005595_abnormal_vascular_smooth0.85122632
111MP0003119_abnormal_digestive_system0.84972168
112MP0000049_abnormal_middle_ear0.84756739
113MP0000534_abnormal_ureter_morphology0.84210759
114MP0002751_abnormal_autonomic_nervous0.83700961
115MP0008004_abnormal_stomach_pH0.83404091
116MP0002233_abnormal_nose_morphology0.82054740
117MP0004484_altered_response_of0.81700910
118MP0001324_abnormal_eye_pigmentation0.80394927
119MP0000026_abnormal_inner_ear0.78845786
120MP0005389_reproductive_system_phenotype0.76912715
121MP0005647_abnormal_sex_gland0.76626503
122MP0003634_abnormal_glial_cell0.76058302
123MP0004858_abnormal_nervous_system0.74711275
124MP0005187_abnormal_penis_morphology0.73768598
125MP0003633_abnormal_nervous_system0.72114657
126MP0004145_abnormal_muscle_electrophysio0.71900650
127MP0002102_abnormal_ear_morphology0.71390719
128MP0004272_abnormal_basement_membrane0.71140794
129MP0003890_abnormal_embryonic-extraembry0.69981284
130MP0003937_abnormal_limbs/digits/tail_de0.69955192
131MP0002909_abnormal_adrenal_gland0.69697481
132MP0003861_abnormal_nervous_system0.69356080
133MP0003755_abnormal_palate_morphology0.68659186
134MP0003045_fibrosis0.68200295

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.18518989
2Febrile seizures (HP:0002373)5.11487971
3Focal motor seizures (HP:0011153)5.06012897
4Epileptic encephalopathy (HP:0200134)4.81480146
5Pancreatic cysts (HP:0001737)4.27552104
6True hermaphroditism (HP:0010459)4.26755800
7Pancreatic fibrosis (HP:0100732)4.09216790
8Abnormality of midbrain morphology (HP:0002418)4.01495617
9Molar tooth sign on MRI (HP:0002419)4.01495617
10Nephronophthisis (HP:0000090)3.76141145
11Excessive salivation (HP:0003781)3.60878974
12Drooling (HP:0002307)3.60878974
13Hyperventilation (HP:0002883)3.58079660
14Focal seizures (HP:0007359)3.54404001
15Myokymia (HP:0002411)3.39482641
16Atonic seizures (HP:0010819)3.38450083
17Abnormality of the renal medulla (HP:0100957)3.27543864
18Central scotoma (HP:0000603)3.18114158
19Chronic hepatic failure (HP:0100626)3.16318288
20Absence seizures (HP:0002121)3.08459450
21Septo-optic dysplasia (HP:0100842)3.04834828
22Progressive cerebellar ataxia (HP:0002073)3.03352579
23Abnormality of the renal cortex (HP:0011035)2.92776829
24Genital tract atresia (HP:0001827)2.92588042
25Cystic liver disease (HP:0006706)2.91458985
26Vaginal atresia (HP:0000148)2.87670315
27Hemiparesis (HP:0001269)2.84332539
28Abnormality of macular pigmentation (HP:0008002)2.81898202
29Broad-based gait (HP:0002136)2.78801102
30Type II lissencephaly (HP:0007260)2.72588605
31Dialeptic seizures (HP:0011146)2.65384014
32Generalized tonic-clonic seizures (HP:0002069)2.64757437
33Abnormal biliary tract physiology (HP:0012439)2.62571270
34Bile duct proliferation (HP:0001408)2.62571270
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.61653354
36Dysdiadochokinesis (HP:0002075)2.58071106
37Methylmalonic acidemia (HP:0002912)2.57994635
38Tubular atrophy (HP:0000092)2.56141485
39Decreased central vision (HP:0007663)2.55754583
40Abnormality of salivation (HP:0100755)2.49367731
41Intestinal atresia (HP:0011100)2.48320062
42Polyphagia (HP:0002591)2.47053639
43Poor coordination (HP:0002370)2.46536877
44Aqueductal stenosis (HP:0002410)2.46413029
45Abnormal rod and cone electroretinograms (HP:0008323)2.45812534
46Inability to walk (HP:0002540)2.43503058
47Occipital encephalocele (HP:0002085)2.43136307
48Bony spicule pigmentary retinopathy (HP:0007737)2.42131806
49Pachygyria (HP:0001302)2.41904701
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.41442754
51Abnormality of the labia minora (HP:0012880)2.40175477
52Sclerocornea (HP:0000647)2.40001348
53Renal cortical cysts (HP:0000803)2.38885135
54Truncal ataxia (HP:0002078)2.38344160
55Postaxial hand polydactyly (HP:0001162)2.36902320
56Epileptiform EEG discharges (HP:0011182)2.35054258
57Blue irides (HP:0000635)2.34505394
58Abnormal hair whorl (HP:0010721)2.34485566
59Thyroid-stimulating hormone excess (HP:0002925)2.30991746
60EEG with generalized epileptiform discharges (HP:0011198)2.29566377
61Asymmetry of the thorax (HP:0001555)2.29354613
62Anencephaly (HP:0002323)2.28711034
63Abolished electroretinogram (ERG) (HP:0000550)2.28478927
64Tubulointerstitial nephritis (HP:0001970)2.27118820
65Scotoma (HP:0000575)2.25353902
66Impaired social interactions (HP:0000735)2.25251753
67Abnormal social behavior (HP:0012433)2.25251753
68Large for gestational age (HP:0001520)2.23789408
69Protruding tongue (HP:0010808)2.22239013
70Postaxial foot polydactyly (HP:0001830)2.21949501
71Narrow nasal bridge (HP:0000446)2.21836589
72Action tremor (HP:0002345)2.21784447
73Congenital sensorineural hearing impairment (HP:0008527)2.21701173
74Hyperglycinemia (HP:0002154)2.19212612
75Absent speech (HP:0001344)2.18222047
76Exotropia (HP:0000577)2.16302927
77Broad metatarsal (HP:0001783)2.15440491
78Attenuation of retinal blood vessels (HP:0007843)2.14838504
79Increased corneal curvature (HP:0100692)2.14650374
80Keratoconus (HP:0000563)2.14650374
81Gaze-evoked nystagmus (HP:0000640)2.11581686
82Progressive inability to walk (HP:0002505)2.07028192
83Severe visual impairment (HP:0001141)2.04360880
84Aplasia/Hypoplasia of the lens (HP:0008063)2.04263765
85Gait imbalance (HP:0002141)2.04066636
86Congenital hepatic fibrosis (HP:0002612)2.02244745
87Short tibia (HP:0005736)2.02067286
88Narrow forehead (HP:0000341)2.01368825
89Widely spaced teeth (HP:0000687)2.01365909
90Male pseudohermaphroditism (HP:0000037)1.99426334
91Polydipsia (HP:0001959)1.96818930
92Abnormal drinking behavior (HP:0030082)1.96818930
93Open mouth (HP:0000194)1.95897452
94Hypsarrhythmia (HP:0002521)1.95549156
95Methylmalonic aciduria (HP:0012120)1.93115154
96Broad foot (HP:0001769)1.91624517
97Hip dysplasia (HP:0001385)1.91184047
98Furrowed tongue (HP:0000221)1.90595487
99Hypoplasia of the brainstem (HP:0002365)1.88871527
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88871527
101Severe Myopia (HP:0011003)1.86920746
102Neoplasm of the adrenal cortex (HP:0100641)1.84867697
103Cerebellar dysplasia (HP:0007033)1.84014770
104Oligodactyly (hands) (HP:0001180)1.83521680
105Absent septum pellucidum (HP:0001331)1.83000639
106Amblyopia (HP:0000646)1.82206251
107Agitation (HP:0000713)1.81675646
108Poor eye contact (HP:0000817)1.81535379
109Preaxial hand polydactyly (HP:0001177)1.81347200
110Pendular nystagmus (HP:0012043)1.80719221
111Prominent nasal bridge (HP:0000426)1.80715040
112Fetal akinesia sequence (HP:0001989)1.80514995
113Retinal dysplasia (HP:0007973)1.79618248
114Concave nail (HP:0001598)1.78662705
115Optic nerve hypoplasia (HP:0000609)1.78042615
116Genetic anticipation (HP:0003743)1.77380028
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76984263
118Fibular hypoplasia (HP:0003038)1.76226476
119Thickened helices (HP:0000391)1.75978669
120Choroideremia (HP:0001139)1.75602938
121Adrenal hypoplasia (HP:0000835)1.75238721
122Congenital primary aphakia (HP:0007707)1.75219835
123Renal hypoplasia (HP:0000089)1.75143271
124Torticollis (HP:0000473)1.74488258
125Scanning speech (HP:0002168)1.73967114
126Severe muscular hypotonia (HP:0006829)1.73704336
127Aganglionic megacolon (HP:0002251)1.73273876
128Multicystic kidney dysplasia (HP:0000003)1.71953712
129Medial flaring of the eyebrow (HP:0010747)1.71908530
130Left ventricular hypertrophy (HP:0001712)1.71901780
131Hypoplastic nipples (HP:0002557)1.71885210
132Failure to thrive in infancy (HP:0001531)1.71733408
133Prolonged QT interval (HP:0001657)1.71691059
134Astigmatism (HP:0000483)1.71515539
135Limb dystonia (HP:0002451)1.71074946
136Dandy-Walker malformation (HP:0001305)1.69694556
137Tubulointerstitial abnormality (HP:0001969)1.69140918
138Spinal cord compression (HP:0002176)1.68963971
139Retinitis pigmentosa (HP:0000510)1.68811363
140Fair hair (HP:0002286)1.68610651
141Hypoventilation (HP:0002791)1.68410624
142Polymicrogyria (HP:0002126)1.67913033
143Delayed gross motor development (HP:0002194)1.67451494
144Submucous cleft hard palate (HP:0000176)1.67109403
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.66497737
146Hypoplasia of the fovea (HP:0007750)1.66497737
147Vascular tortuosity (HP:0004948)1.65746315
148Nephrogenic diabetes insipidus (HP:0009806)1.65146751
149Specific learning disability (HP:0001328)1.64399554
150Dysmetria (HP:0001310)1.63684056
151Arterial tortuosity (HP:0005116)1.63586295
152Abnormal ciliary motility (HP:0012262)1.62117938
153Cutaneous finger syndactyly (HP:0010554)1.61773869
154Aplasia involving bones of the upper limbs (HP:0009823)1.60961530
155Aplasia of the phalanges of the hand (HP:0009802)1.60961530
156Aplasia involving bones of the extremities (HP:0009825)1.60961530
157Split foot (HP:0001839)1.60313823
158Midline defect of the nose (HP:0004122)1.59447195
159Abnormality of incisor morphology (HP:0011063)1.59274614
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.58957621
161Shallow orbits (HP:0000586)1.58746853
162Abnormal respiratory motile cilium physiology (HP:0012261)1.58169984
163Abnormality of dentin (HP:0010299)1.57454811
164Depression (HP:0000716)1.55922353
165Abnormality of the nasal septum (HP:0000419)1.55221214
166Abnormality of the septum pellucidum (HP:0007375)1.54218454
167Lissencephaly (HP:0001339)1.54131294
168Short foot (HP:0001773)1.53622997
169Generalized hypopigmentation of hair (HP:0011358)1.52945307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.88756750
2MARK13.31567159
3MAP4K23.17551325
4NTRK33.05394054
5MAP3K43.00557162
6SIK32.84400320
7TRIM282.47427234
8PRPF4B2.35273345
9MAP2K72.34436729
10EPHA42.30021458
11PINK12.24715615
12ADRBK22.24049404
13INSRR2.20120318
14NTRK22.07608542
15MINK12.00874338
16AKT32.00513980
17BCR1.92541722
18WNK41.82111981
19NUAK11.81931915
20MAPK131.81491822
21TNIK1.69842511
22PAK61.67480516
23PLK21.59731782
24SIK21.51981936
25ZAK1.51482296
26DDR21.51158985
27MUSK1.47124587
28DAPK21.44519358
29TAOK21.44458953
30IRAK21.43717204
31ERBB31.39497311
32PNCK1.38880702
33CDK31.31050230
34KSR11.30611600
35SGK21.29123081
36SGK4941.28163775
37SGK2231.28163775
38FRK1.25557241
39PAK31.21936533
40CSNK1G21.21621409
41MAP2K41.17926690
42CDK51.16662558
43CSNK1G11.15396590
44PHKG11.14256544
45PHKG21.14256544
46CAMK1G1.14242675
47STK391.14190869
48CSNK1A1L1.13428585
49YES11.13381449
50MAP3K91.11883702
51CSNK1G31.11621184
52TIE11.11334558
53FER1.09608119
54FGFR21.09401088
55RIPK41.06716106
56CAMK2A1.05604215
57PRKCE1.04750064
58BMPR1B1.04280658
59UHMK11.02952651
60DYRK21.02665951
61STK38L1.01693702
62PRKCG1.00793677
63LIMK10.98432553
64MKNK20.92214995
65DYRK1B0.91641617
66DYRK1A0.91593004
67SGK30.89172530
68OXSR10.87441927
69PKN10.87029674
70DYRK30.86114504
71CAMK2B0.84571978
72MAP3K120.83784990
73PIK3CA0.83166599
74SIK10.83006687
75EPHA30.81786218
76NTRK10.79651540
77NME10.78448327
78ROCK20.78300006
79TAOK30.76568090
80CAMK2D0.73542313
81CAMK10.73509730
82ACVR1B0.73382699
83MAP3K60.72999779
84CAMKK20.69382354
85BMPR20.68510765
86PRKCH0.68475749
87TLK10.68402035
88ROCK10.67779472
89SGK10.65190080
90GRK50.63753527
91PRKAA10.61753205
92STK380.61589260
93PTK2B0.60460666
94MARK20.59540784
95RPS6KA20.58831691
96BCKDK0.57723928
97FGR0.57172424
98CSNK1A10.56355152
99ERBB20.55916946
100ADRBK10.55127525
101FES0.54886936
102CDK180.54406397
103MAPKAPK30.54036041
104CAMK40.54004011
105VRK10.53746223
106PRKG10.53661886
107CAMK1D0.52642637
108GRK10.52510011
109CAMKK10.52504165
110STK110.51812043
111WNK30.49639846
112STK30.48568817
113CDK140.47322419
114IRAK10.47204469
115CSNK1D0.46911965
116NEK60.46565107
117MAPK150.45493430
118BMX0.45424131
119RPS6KA30.45308411
120LATS10.45135569
121PRKCB0.43445598
122DAPK10.42927697
123FYN0.42630565
124EPHB20.42558237
125ERBB40.42432698
126PRKCZ0.40932312
127CDK150.40304547
128RET0.39459868
129RPS6KB10.38651354
130PRKACA0.37202184
131MAPK100.36635210
132PRKAA20.35544597
133GRK70.35484740
134GSK3B0.35326661
135PRKD20.35052899
136PRKD30.34765232
137TYRO30.34374339
138MAP3K70.33555629
139NLK0.31516261
140MKNK10.29320065
141PLK30.29065950
142RPS6KA50.28316842
143STK160.28032011

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98532849
2GABAergic synapse_Homo sapiens_hsa047272.80329653
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73411186
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71020067
5Morphine addiction_Homo sapiens_hsa050322.57745400
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53434805
7Synaptic vesicle cycle_Homo sapiens_hsa047212.48089665
8Circadian entrainment_Homo sapiens_hsa047132.42191996
9Butanoate metabolism_Homo sapiens_hsa006502.29965549
10Glutamatergic synapse_Homo sapiens_hsa047242.23671383
11Protein export_Homo sapiens_hsa030602.19057589
12Olfactory transduction_Homo sapiens_hsa047402.11691866
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07334817
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04071524
15Phototransduction_Homo sapiens_hsa047441.92577976
16Cholinergic synapse_Homo sapiens_hsa047251.90428075
17Linoleic acid metabolism_Homo sapiens_hsa005911.90201847
18Serotonergic synapse_Homo sapiens_hsa047261.88605232
19Insulin secretion_Homo sapiens_hsa049111.87603583
20Renin secretion_Homo sapiens_hsa049241.86589228
21Dopaminergic synapse_Homo sapiens_hsa047281.85191086
22Salivary secretion_Homo sapiens_hsa049701.83410299
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.78406220
24Nitrogen metabolism_Homo sapiens_hsa009101.77877058
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74266453
26Selenocompound metabolism_Homo sapiens_hsa004501.73860933
27Amphetamine addiction_Homo sapiens_hsa050311.71750582
28Long-term potentiation_Homo sapiens_hsa047201.70995269
29Propanoate metabolism_Homo sapiens_hsa006401.67463513
30Axon guidance_Homo sapiens_hsa043601.63675263
31Long-term depression_Homo sapiens_hsa047301.60039642
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54347939
33Oxidative phosphorylation_Homo sapiens_hsa001901.53863717
34Ether lipid metabolism_Homo sapiens_hsa005651.50843936
35Taste transduction_Homo sapiens_hsa047421.50662087
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49072290
37Oxytocin signaling pathway_Homo sapiens_hsa049211.48131054
38Calcium signaling pathway_Homo sapiens_hsa040201.44694126
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44097817
40Gap junction_Homo sapiens_hsa045401.40729991
41Basal transcription factors_Homo sapiens_hsa030221.38483859
42GnRH signaling pathway_Homo sapiens_hsa049121.37702693
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37350540
44Cocaine addiction_Homo sapiens_hsa050301.34849831
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31213985
46Peroxisome_Homo sapiens_hsa041461.27709425
47Tryptophan metabolism_Homo sapiens_hsa003801.26983991
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.23312179
49Steroid biosynthesis_Homo sapiens_hsa001001.23211794
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22393864
51cAMP signaling pathway_Homo sapiens_hsa040241.22167661
52Regulation of autophagy_Homo sapiens_hsa041401.21315516
53Type II diabetes mellitus_Homo sapiens_hsa049301.18476905
54Dilated cardiomyopathy_Homo sapiens_hsa054141.18167806
55Gastric acid secretion_Homo sapiens_hsa049711.17484350
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16170637
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15888749
58Collecting duct acid secretion_Homo sapiens_hsa049661.14635667
59ABC transporters_Homo sapiens_hsa020101.12276345
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09646903
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07292426
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07074563
63Parkinsons disease_Homo sapiens_hsa050121.05894444
64ErbB signaling pathway_Homo sapiens_hsa040121.04776837
65Glioma_Homo sapiens_hsa052141.04392316
66Circadian rhythm_Homo sapiens_hsa047101.03687695
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00469984
68Estrogen signaling pathway_Homo sapiens_hsa049150.97453159
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93220392
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.92024943
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91985542
72beta-Alanine metabolism_Homo sapiens_hsa004100.88757277
73Melanogenesis_Homo sapiens_hsa049160.87132962
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86840928
75Caffeine metabolism_Homo sapiens_hsa002320.86696088
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.85871428
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85690481
78RNA degradation_Homo sapiens_hsa030180.83927670
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83673606
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83533308
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81636781
82Ras signaling pathway_Homo sapiens_hsa040140.80750154
83Melanoma_Homo sapiens_hsa052180.80213541
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79449914
85Ovarian steroidogenesis_Homo sapiens_hsa049130.79174161
86MAPK signaling pathway_Homo sapiens_hsa040100.78827950
87Renal cell carcinoma_Homo sapiens_hsa052110.77940135
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75271757
89Choline metabolism in cancer_Homo sapiens_hsa052310.75152761
90Chemical carcinogenesis_Homo sapiens_hsa052040.73728710
91Alzheimers disease_Homo sapiens_hsa050100.73305874
92Endometrial cancer_Homo sapiens_hsa052130.73006757
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72469091
94Rap1 signaling pathway_Homo sapiens_hsa040150.72093805
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71879489
96Fanconi anemia pathway_Homo sapiens_hsa034600.70561981
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70182059
98Fatty acid metabolism_Homo sapiens_hsa012120.69568471
99Huntingtons disease_Homo sapiens_hsa050160.68986744
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.68519867
101Vibrio cholerae infection_Homo sapiens_hsa051100.68408893
102Wnt signaling pathway_Homo sapiens_hsa043100.67405133
103Cardiac muscle contraction_Homo sapiens_hsa042600.66098293
104Arachidonic acid metabolism_Homo sapiens_hsa005900.64757995
105RNA polymerase_Homo sapiens_hsa030200.62705334
106Retinol metabolism_Homo sapiens_hsa008300.62421366
107Colorectal cancer_Homo sapiens_hsa052100.61328528
108Fatty acid elongation_Homo sapiens_hsa000620.61234230
109Thyroid hormone synthesis_Homo sapiens_hsa049180.60714353
110ECM-receptor interaction_Homo sapiens_hsa045120.60315625
111Alcoholism_Homo sapiens_hsa050340.59345495
112Rheumatoid arthritis_Homo sapiens_hsa053230.58743066
113Metabolic pathways_Homo sapiens_hsa011000.55074720
114Focal adhesion_Homo sapiens_hsa045100.54608343
115Phagosome_Homo sapiens_hsa041450.53368335
116Pancreatic secretion_Homo sapiens_hsa049720.53347895
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53151114
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53072083
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52678400
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52379576
121Glucagon signaling pathway_Homo sapiens_hsa049220.51429061
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50675144
123Type I diabetes mellitus_Homo sapiens_hsa049400.50548699
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50528447
125African trypanosomiasis_Homo sapiens_hsa051430.48267873
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48093283
127Hedgehog signaling pathway_Homo sapiens_hsa043400.46532059
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46234963
129mTOR signaling pathway_Homo sapiens_hsa041500.44060945
130Fatty acid degradation_Homo sapiens_hsa000710.43999868
131Amoebiasis_Homo sapiens_hsa051460.43780229
132Histidine metabolism_Homo sapiens_hsa003400.43624921
133Fat digestion and absorption_Homo sapiens_hsa049750.42687144
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42425297
135Sphingolipid metabolism_Homo sapiens_hsa006000.41960452
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41853661
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.41746013
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.40882272
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40825544
140Inositol phosphate metabolism_Homo sapiens_hsa005620.40672120
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39909824
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39757654
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.39750845
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38998619
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38491562
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38283046
147Hippo signaling pathway_Homo sapiens_hsa043900.37645340
148Prostate cancer_Homo sapiens_hsa052150.36664904
149Proteoglycans in cancer_Homo sapiens_hsa052050.35504173
150Basal cell carcinoma_Homo sapiens_hsa052170.34100361
151VEGF signaling pathway_Homo sapiens_hsa043700.32458833
152Dorso-ventral axis formation_Homo sapiens_hsa043200.31171620
153Mineral absorption_Homo sapiens_hsa049780.31075319

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