ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cornea development in camera-type eye (GO:0061303)	5.32882486
2	neuron cell-cell adhesion (GO:0007158)	4.74201025
3	behavioral response to nicotine (GO:0035095)	4.20580744
4	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.07077109
5	regulation of mitotic spindle checkpoint (GO:1903504)	4.07077109
6	postsynaptic membrane organization (GO:0001941)	3.91422264
7	peptidyl-lysine dimethylation (GO:0018027)	3.89810332
8	olfactory bulb development (GO:0021772)	3.87010569
9	presynaptic membrane assembly (GO:0097105)	3.86548498
10	central nervous system projection neuron axonogenesis (GO:0021952)	3.86504855
11	positive regulation of cell cycle checkpoint (GO:1901978)	3.83505808
12	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.70685122
13	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.63167555
14	sympathetic nervous system development (GO:0048485)	3.62269402
15	sequestering of actin monomers (GO:0042989)	3.58153549
16	translesion synthesis (GO:0019985)	3.57290636
17	presynaptic membrane organization (GO:0097090)	3.52256253
18	vocalization behavior (GO:0071625)	3.49459599
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.46958477
20	intraciliary transport (GO:0042073)	3.36874598
21	histone H3-K9 methylation (GO:0051567)	3.33227965
22	auditory behavior (GO:0031223)	3.32433548
23	gamma-aminobutyric acid transport (GO:0015812)	3.27416561
24	head development (GO:0060322)	3.26767584
25	locomotory exploration behavior (GO:0035641)	3.26761909
26	neurotransmitter-gated ion channel clustering (GO:0072578)	3.24022775
27	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.22534902
28	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.21912061
29	regulation of axon regeneration (GO:0048679)	3.21832282
30	regulation of neuron projection regeneration (GO:0070570)	3.21832282
31	positive regulation of synapse assembly (GO:0051965)	3.17560585
32	protein localization to synapse (GO:0035418)	3.14651298
33	mechanosensory behavior (GO:0007638)	3.04622657
34	limb bud formation (GO:0060174)	3.03956169
35	positive regulation of amino acid transport (GO:0051957)	3.03115370
36	establishment of mitochondrion localization (GO:0051654)	2.98401187
37	layer formation in cerebral cortex (GO:0021819)	2.97121198
38	central nervous system neuron axonogenesis (GO:0021955)	2.95221311
39	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.89994702
40	glial cell proliferation (GO:0014009)	2.85618841
41	neuron recognition (GO:0008038)	2.84913218
42	L-serine metabolic process (GO:0006563)	2.81844395
43	regulation of transmission of nerve impulse (GO:0051969)	2.80892043
44	regulation of collateral sprouting (GO:0048670)	2.78459579
45	synaptic transmission, cholinergic (GO:0007271)	2.76796718
46	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.72870900
47	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.72870900
48	spinal cord association neuron differentiation (GO:0021527)	2.72862749
49	synapse assembly (GO:0007416)	2.72032564
50	nucleobase catabolic process (GO:0046113)	2.70734030
51	peptidyl-cysteine modification (GO:0018198)	2.70273568
52	regulation of centrosome duplication (GO:0010824)	2.69503775
53	retina layer formation (GO:0010842)	2.66360386
54	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.65209266
55	hindbrain development (GO:0030902)	2.62817142
56	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.62546805
57	regulation of synapse assembly (GO:0051963)	2.60673401
58	regulation of development, heterochronic (GO:0040034)	2.60271114
59	axonal fasciculation (GO:0007413)	2.59969959
60	nonmotile primary cilium assembly (GO:0035058)	2.58579447
61	ectodermal placode formation (GO:0060788)	2.55611944
62	retinal ganglion cell axon guidance (GO:0031290)	2.55573866
63	regulation of axon guidance (GO:1902667)	2.55040738
64	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.54860936
65	GPI anchor metabolic process (GO:0006505)	2.54722337
66	neural tube formation (GO:0001841)	2.53590121
67	DNA double-strand break processing (GO:0000729)	2.52592278
68	dendritic spine morphogenesis (GO:0060997)	2.52541810
69	glycosphingolipid biosynthetic process (GO:0006688)	2.52430023
70	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.51793279
71	collecting duct development (GO:0072044)	2.51687749
72	negative regulation of circadian rhythm (GO:0042754)	2.51588130
73	vascular smooth muscle contraction (GO:0014829)	2.50228153
74	kinetochore organization (GO:0051383)	2.50170675
75	somite development (GO:0061053)	2.49467685
76	regulation of spindle checkpoint (GO:0090231)	2.49326639
77	histone H3-K9 modification (GO:0061647)	2.49188625
78	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.48131900
79	postreplication repair (GO:0006301)	2.47463423
80	generation of neurons (GO:0048699)	2.44662344
81	meiotic chromosome segregation (GO:0045132)	2.44651816
82	cilium assembly (GO:0042384)	2.44470969
83	C-terminal protein lipidation (GO:0006501)	2.40269856
84	ephrin receptor signaling pathway (GO:0048013)	2.39571186
85	regulation of centrosome cycle (GO:0046605)	2.39483582
86	synaptic vesicle endocytosis (GO:0048488)	2.38638182
87	cilium organization (GO:0044782)	2.37993469
88	protein neddylation (GO:0045116)	2.36575708
89	negative regulation of axonogenesis (GO:0050771)	2.36450055
90	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.35600783
91	mitochondrion transport along microtubule (GO:0047497)	2.35600783
92	cerebral cortex radially oriented cell migration (GO:0021799)	2.35008393
93	fatty acid elongation (GO:0030497)	2.32795419
94	exploration behavior (GO:0035640)	2.32536946
95	positive regulation of dendrite morphogenesis (GO:0050775)	2.32003629
96	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.31738913
97	regulation of hippo signaling (GO:0035330)	2.31679704
98	GPI anchor biosynthetic process (GO:0006506)	2.31531348
99	neuroblast proliferation (GO:0007405)	2.30645387
100	protein K11-linked deubiquitination (GO:0035871)	2.30241659

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.51760223
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.02778840
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.43717501
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.05034663
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.90106151
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89429398
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.72021439
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.56157831
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55458972
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.28809204
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.23657044
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20597454
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.19833656
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12750362
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96446776
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94372188
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93303742
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.87807309
19	EWS_26573619_Chip-Seq_HEK293_Human	1.86327551
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80556835
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76027103
22	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.73786221
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.70988579
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65271270
25	FUS_26573619_Chip-Seq_HEK293_Human	1.65229288
26	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63808863
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.59791369
28	P300_19829295_ChIP-Seq_ESCs_Human	1.58408873
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.58041173
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.56516115
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55371395
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53256994
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48113563
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.48113563
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.46294144
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45526490
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.45145940
38	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.43142510
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42897568
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.42197654
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41691224
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.38167403
43	SOX9_26525672_Chip-Seq_HEART_Mouse	1.37862060
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.32847925
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32073345
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29926621
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24488561
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24361791
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22228040
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20356500
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20213937
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19941074
53	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18723268
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17854485
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14625929
56	STAT3_23295773_ChIP-Seq_U87_Human	1.13736083
57	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.13575300
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13166506
59	JUN_21703547_ChIP-Seq_K562_Human	1.12872125
60	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.11989770
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11301358
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10957713
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10292716
64	VDR_22108803_ChIP-Seq_LS180_Human	1.10284802
65	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.10228640
66	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.09835400
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09330389
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09330389
69	AR_25329375_ChIP-Seq_VCAP_Human	1.08414318
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08303462
71	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.07774082
72	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06325070
73	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05267107
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03860524
75	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03149683
76	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03149683
77	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03007462
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02849109
79	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01883397
80	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01399813
81	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	1.01282371
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00839864
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00339262
84	TCF4_23295773_ChIP-Seq_U87_Human	1.00234622
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99127524
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98080221
87	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97890189
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97211896
89	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96214355
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94937253
91	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94193522
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93173940
93	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.92730013
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.90849139
95	AHR_22903824_ChIP-Seq_MCF-7_Human	0.89721365
96	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.89206948
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.89092990
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88884861
99	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.88748336
100	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87884385

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	2.76534779
2	MP0005248_abnormal_Harderian_gland	2.68687117
3	MP0003880_abnormal_central_pattern	2.57891788
4	MP0000778_abnormal_nervous_system	2.48866763
5	MP0001529_abnormal_vocalization	2.34968008
6	MP0005423_abnormal_somatic_nervous	2.30209301
7	MP0002234_abnormal_pharynx_morphology	2.28448914
8	MP0002736_abnormal_nociception_after	2.16913021
9	MP0002254_reproductive_system_inflammat	2.16151878
10	MP0002653_abnormal_ependyma_morphology	2.12356838
11	MP0002638_abnormal_pupillary_reflex	1.98411329
12	MP0001968_abnormal_touch/_nociception	1.89982547
13	MP0004270_analgesia	1.89474645
14	MP0004782_abnormal_surfactant_physiolog	1.88406602
15	MP0002090_abnormal_vision	1.87739811
16	MP0002751_abnormal_autonomic_nervous	1.82303922
17	MP0005171_absent_coat_pigmentation	1.75341836
18	MP0002909_abnormal_adrenal_gland	1.74104813
19	MP0001984_abnormal_olfaction	1.71835833
20	MP0001293_anophthalmia	1.66073191
21	MP0006276_abnormal_autonomic_nervous	1.62765326
22	MP0000631_abnormal_neuroendocrine_gland	1.62750168
23	MP0003136_yellow_coat_color	1.62028676
24	MP0000427_abnormal_hair_cycle	1.57988550
25	MP0000537_abnormal_urethra_morphology	1.57710203
26	MP0006072_abnormal_retinal_apoptosis	1.55009220
27	MP0002557_abnormal_social/conspecific_i	1.54799668
28	MP0002735_abnormal_chemical_nociception	1.53513706
29	MP0001486_abnormal_startle_reflex	1.53482969
30	MP0000049_abnormal_middle_ear	1.52103718
31	MP0002160_abnormal_reproductive_system	1.51333023
32	MP0002734_abnormal_mechanical_nocicepti	1.51319959
33	MP0003635_abnormal_synaptic_transmissio	1.51024607
34	MP0001346_abnormal_lacrimal_gland	1.48090816
35	MP0010030_abnormal_orbit_morphology	1.47817800
36	MP0005187_abnormal_penis_morphology	1.47382538
37	MP0005646_abnormal_pituitary_gland	1.45522731
38	MP0004742_abnormal_vestibular_system	1.44769481
39	MP0000647_abnormal_sebaceous_gland	1.43936680
40	MP0003937_abnormal_limbs/digits/tail_de	1.42764129
41	MP0004133_heterotaxia	1.40841350
42	MP0002063_abnormal_learning/memory/cond	1.38289029
43	MP0009046_muscle_twitch	1.32263121
44	MP0003787_abnormal_imprinting	1.29399301
45	MP0003890_abnormal_embryonic-extraembry	1.27488963
46	MP0002882_abnormal_neuron_morphology	1.24917293
47	MP0002067_abnormal_sensory_capabilities	1.24150584
48	MP0000751_myopathy	1.24048175
49	MP0002697_abnormal_eye_size	1.22860140
50	MP0002152_abnormal_brain_morphology	1.22650206
51	MP0005551_abnormal_eye_electrophysiolog	1.22177968
52	MP0001299_abnormal_eye_distance/	1.21899203
53	MP0003861_abnormal_nervous_system	1.21818737
54	MP0008789_abnormal_olfactory_epithelium	1.21658770
55	MP0002572_abnormal_emotion/affect_behav	1.20703736
56	MP0010386_abnormal_urinary_bladder	1.20408240
57	MP0002184_abnormal_innervation	1.19980527
58	MP0002272_abnormal_nervous_system	1.17484250
59	MP0004811_abnormal_neuron_physiology	1.13574436
60	MP0005394_taste/olfaction_phenotype	1.13235895
61	MP0005499_abnormal_olfactory_system	1.13235895
62	MP0006292_abnormal_olfactory_placode	1.12892775
63	MP0005253_abnormal_eye_physiology	1.12878484
64	MP0003122_maternal_imprinting	1.11377132
65	MP0009745_abnormal_behavioral_response	1.11370984
66	MP0005389_reproductive_system_phenotype	1.11007357
67	MP0000569_abnormal_digit_pigmentation	1.09064931
68	MP0002233_abnormal_nose_morphology	1.08509560
69	MP0002752_abnormal_somatic_nervous	1.07859816
70	MP0000955_abnormal_spinal_cord	1.07806324
71	MP0001286_abnormal_eye_development	1.07249020
72	MP0000579_abnormal_nail_morphology	1.06611195
73	MP0005645_abnormal_hypothalamus_physiol	1.06603158
74	MP0004142_abnormal_muscle_tone	1.05999301
75	MP0008932_abnormal_embryonic_tissue	1.05244408
76	MP0003119_abnormal_digestive_system	1.05014014
77	MP0001177_atelectasis	1.04096628
78	MP0003115_abnormal_respiratory_system	1.03763754
79	MP0003755_abnormal_palate_morphology	1.03531425
80	MP0003942_abnormal_urinary_system	1.02555650
81	MP0002092_abnormal_eye_morphology	1.00221729
82	MP0003221_abnormal_cardiomyocyte_apopto	0.99353503
83	MP0002282_abnormal_trachea_morphology	0.99328878
84	MP0004924_abnormal_behavior	0.97406743
85	MP0005386_behavior/neurological_phenoty	0.97406743
86	MP0000026_abnormal_inner_ear	0.97181527
87	MP0005391_vision/eye_phenotype	0.97103214
88	MP0001963_abnormal_hearing_physiology	0.95780451
89	MP0001919_abnormal_reproductive_system	0.95692241
90	MP0003567_abnormal_fetal_cardiomyocyte	0.95349202
91	MP0001970_abnormal_pain_threshold	0.91273571
92	MP0005195_abnormal_posterior_eye	0.89098671
93	MP0004147_increased_porphyrin_level	0.87504556
94	MP0002064_seizures	0.84407213
95	MP0003634_abnormal_glial_cell	0.84340171
96	MP0004885_abnormal_endolymph	0.83002354
97	MP0003385_abnormal_body_wall	0.82223454
98	MP0001879_abnormal_lymphatic_vessel	0.81418355
99	MP0003693_abnormal_embryo_hatching	0.80563242
100	MP0003941_abnormal_skin_development	0.77583406

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	4.39830337
2	Chronic hepatic failure (HP:0100626)	3.79401978
3	True hermaphroditism (HP:0010459)	3.67680296
4	Gait imbalance (HP:0002141)	3.10739196
5	Optic nerve hypoplasia (HP:0000609)	3.05415493
6	Vitreoretinal degeneration (HP:0000655)	2.97693929
7	Occipital encephalocele (HP:0002085)	2.92984964
8	Nephronophthisis (HP:0000090)	2.92652345
9	Congenital primary aphakia (HP:0007707)	2.89406264
10	Abnormality of midbrain morphology (HP:0002418)	2.82905755
11	Molar tooth sign on MRI (HP:0002419)	2.82905755
12	Termporal pattern (HP:0011008)	2.79443835
13	Insidious onset (HP:0003587)	2.79443835
14	Pancreatic cysts (HP:0001737)	2.73002201
15	Medial flaring of the eyebrow (HP:0010747)	2.72669687
16	Pancreatic fibrosis (HP:0100732)	2.72401889
17	Increased hepatocellular lipid droplets (HP:0006565)	2.70493519
18	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.67773173
19	Nephrogenic diabetes insipidus (HP:0009806)	2.56160861
20	Severe Myopia (HP:0011003)	2.54992468
21	Abnormal biliary tract physiology (HP:0012439)	2.54659767
22	Bile duct proliferation (HP:0001408)	2.54659767
23	Concave nail (HP:0001598)	2.53013538
24	Poor coordination (HP:0002370)	2.47272126
25	Oligodactyly (hands) (HP:0001180)	2.45640864
26	Lipid accumulation in hepatocytes (HP:0006561)	2.42320194
27	Bifid tongue (HP:0010297)	2.40635717
28	Cystic liver disease (HP:0006706)	2.32199283
29	Vaginal atresia (HP:0000148)	2.31232128
30	Epileptic encephalopathy (HP:0200134)	2.29725248
31	Absent septum pellucidum (HP:0001331)	2.26857955
32	Atonic seizures (HP:0010819)	2.25914722
33	Genital tract atresia (HP:0001827)	2.19595895
34	Abnormality of the septum pellucidum (HP:0007375)	2.15383476
35	Focal seizures (HP:0007359)	2.14993431
36	Hyperventilation (HP:0002883)	2.14604244
37	Dyschromatopsia (HP:0007641)	2.09993939
38	Broad nasal tip (HP:0000455)	2.09184091
39	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08423056
40	Abnormality of the intervertebral disk (HP:0005108)	2.07025731
41	Abnormality of the renal medulla (HP:0100957)	2.05333635
42	High anterior hairline (HP:0009890)	2.05311345
43	Split foot (HP:0001839)	2.04371236
44	Postaxial hand polydactyly (HP:0001162)	2.03497203
45	Amyotrophic lateral sclerosis (HP:0007354)	2.00339887
46	Hepatocellular necrosis (HP:0001404)	1.99447353
47	Leiomyosarcoma (HP:0100243)	1.99410258
48	Uterine leiomyosarcoma (HP:0002891)	1.99410258
49	Supernumerary spleens (HP:0009799)	1.99296864
50	Sclerocornea (HP:0000647)	1.98367974
51	Aganglionic megacolon (HP:0002251)	1.96018475
52	Astigmatism (HP:0000483)	1.95755364
53	Specific learning disability (HP:0001328)	1.94908234
54	Rib fusion (HP:0000902)	1.94141286
55	Focal motor seizures (HP:0011153)	1.91315610
56	Postaxial foot polydactyly (HP:0001830)	1.90568449
57	Hypoplastic pelvis (HP:0008839)	1.90402086
58	Hyperglycinemia (HP:0002154)	1.89920421
59	Cerebellar dysplasia (HP:0007033)	1.89573040
60	Retinal dysplasia (HP:0007973)	1.87447972
61	Meckel diverticulum (HP:0002245)	1.86725684
62	Partial agenesis of the corpus callosum (HP:0001338)	1.86329519
63	Tubulointerstitial nephritis (HP:0001970)	1.86264781
64	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.86157037
65	Abnormality of the ileum (HP:0001549)	1.85309580
66	Oligodactyly (HP:0012165)	1.84272684
67	Broad foot (HP:0001769)	1.82821962
68	Impaired vibration sensation in the lower limbs (HP:0002166)	1.82294726
69	Transitional cell carcinoma of the bladder (HP:0006740)	1.81626209
70	Preaxial hand polydactyly (HP:0001177)	1.81391197
71	Abnormality of the corticospinal tract (HP:0002492)	1.78599500
72	Disproportionate short-trunk short stature (HP:0003521)	1.78413887
73	Mitochondrial inheritance (HP:0001427)	1.78048178
74	Hypsarrhythmia (HP:0002521)	1.73786293
75	Broad-based gait (HP:0002136)	1.73707368
76	Anencephaly (HP:0002323)	1.72951301
77	Narrow forehead (HP:0000341)	1.72581466
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71924222
79	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.69496173
80	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.69496173
81	Abnormality of the sella turcica (HP:0002679)	1.68485749
82	Renal Fanconi syndrome (HP:0001994)	1.68179654
83	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.68007375
84	Congenital hepatic fibrosis (HP:0002612)	1.67216578
85	Unilateral renal agenesis (HP:0000122)	1.66983274
86	Amblyopia (HP:0000646)	1.66653304
87	Abnormality of the lower motor neuron (HP:0002366)	1.66225283
88	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.66222688
89	EEG with generalized epileptiform discharges (HP:0011198)	1.65165022
90	Pachygyria (HP:0001302)	1.64986664
91	Epileptiform EEG discharges (HP:0011182)	1.64686029
92	Intestinal atresia (HP:0011100)	1.64337406
93	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.64003323
94	Growth hormone deficiency (HP:0000824)	1.63150731
95	Patellar aplasia (HP:0006443)	1.62023626
96	Spina bifida occulta (HP:0003298)	1.61305342
97	Lissencephaly (HP:0001339)	1.61277317
98	Short philtrum (HP:0000322)	1.60202693
99	Aplasia/Hypoplasia of the lens (HP:0008063)	1.59842514
100	Acute encephalopathy (HP:0006846)	1.58153772

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.85475009
2	BCR	4.08645492
3	ERBB3	3.61240319
4	MARK1	3.15699384
5	TRIM28	2.70333668
6	CAMK1D	2.65397951
7	DYRK3	2.56929245
8	WNK3	2.27484576
9	LIMK1	2.19993311
10	EPHA4	2.10400388
11	BCKDK	1.98607586
12	MAP3K4	1.94013603
13	TESK1	1.90447359
14	CAMKK2	1.87919513
15	DYRK2	1.83400700
16	CSNK1G2	1.78500569
17	CAMK1G	1.78008980
18	CSNK1G3	1.75080444
19	CSNK1A1L	1.62697395
20	PBK	1.61203167
21	MINK1	1.57261720
22	CSNK1G1	1.57114522
23	NTRK2	1.56551923
24	MKNK1	1.47259453
25	MAP2K7	1.45216310
26	SRPK1	1.42914629
27	LATS1	1.42457037
28	ERBB4	1.41209796
29	EPHB2	1.39476533
30	MAPK13	1.32957138
31	SIK3	1.32864977
32	ZAK	1.24179521
33	BRD4	1.24035154
34	PINK1	1.19279485
35	MKNK2	1.17479016
36	CDC7	1.14074036
37	CAMK4	1.13271137
38	NEK1	1.11644628
39	ERBB2	1.11228523
40	PLK2	1.08697356
41	UHMK1	1.05718133
42	RPS6KA4	1.02263174
43	CDK19	1.00106135
44	STK38L	0.99529317
45	DYRK1B	0.98818172
46	FER	0.98514707
47	CAMK2B	0.93331800
48	NTRK3	0.91133994
49	WEE1	0.89650854
50	DYRK1A	0.86929239
51	KSR1	0.86597435
52	NUAK1	0.86219326
53	PRKCE	0.82874103
54	CAMKK1	0.81512892
55	PKN1	0.77539310
56	PAK4	0.73370708
57	NEK9	0.67381340
58	PAK3	0.66732318
59	PDGFRA	0.65404056
60	NTRK1	0.64868521
61	CCNB1	0.63539166
62	STK16	0.62404847
63	CAMK1	0.59488510
64	PRKCG	0.59099399
65	CAMK2A	0.58714034
66	CDK3	0.56974011
67	WNK4	0.56623330
68	CDK14	0.55417070
69	PLK1	0.55150517
70	AKT2	0.54689118
71	PRKD3	0.52508328
72	CAMK2G	0.52393598
73	MAP4K2	0.52000777
74	MET	0.50413893
75	PAK6	0.49557248
76	CAMK2D	0.47060722
77	CSNK1D	0.46374153
78	DMPK	0.44161705
79	MARK2	0.42270642
80	BMPR2	0.42131561
81	CDK18	0.40644532
82	PIK3CA	0.40187234
83	CDK6	0.39886912
84	ROCK2	0.39611383
85	CDK8	0.38657423
86	CDK5	0.34736619
87	CSNK1E	0.34320687
88	ATM	0.32731234
89	ATR	0.32646789
90	CDK11A	0.32361461
91	PRKCI	0.31280012
92	TESK2	0.30489638
93	ADRBK2	0.30215740
94	CDK15	0.29277634
95	SGK494	0.29186266
96	SGK223	0.29186266
97	EIF2AK1	0.26868707
98	CSNK1A1	0.25639325
99	STK38	0.23382186
100	CDK9	0.23080032

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.43202013
2	Nicotine addiction_Homo sapiens_hsa05033	3.05414275
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95716204
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.94072117
5	Fatty acid elongation_Homo sapiens_hsa00062	2.64059818
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.48555380
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20220614
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.12067846
9	Homologous recombination_Homo sapiens_hsa03440	2.06613739
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03516492
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.90772111
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81839073
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.79499028
14	Axon guidance_Homo sapiens_hsa04360	1.79113796
15	GABAergic synapse_Homo sapiens_hsa04727	1.70392270
16	Butanoate metabolism_Homo sapiens_hsa00650	1.67942767
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.62882057
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.58095754
19	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.48427803
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.44126793
21	Hippo signaling pathway_Homo sapiens_hsa04390	1.43129377
22	Morphine addiction_Homo sapiens_hsa05032	1.39579697
23	Circadian entrainment_Homo sapiens_hsa04713	1.36079797
24	Propanoate metabolism_Homo sapiens_hsa00640	1.35784183
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28817413
26	Dopaminergic synapse_Homo sapiens_hsa04728	1.26413086
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.25910059
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24726576
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22574363
30	Basal transcription factors_Homo sapiens_hsa03022	1.22342635
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.19937320
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16841078
33	Taste transduction_Homo sapiens_hsa04742	1.15081752
34	Melanogenesis_Homo sapiens_hsa04916	1.06941898
35	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.05378776
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.03588615
37	Lysine degradation_Homo sapiens_hsa00310	1.02726631
38	mRNA surveillance pathway_Homo sapiens_hsa03015	1.00240133
39	Non-homologous end-joining_Homo sapiens_hsa03450	0.98597789
40	RNA degradation_Homo sapiens_hsa03018	0.95229683
41	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.93404681
42	Sulfur relay system_Homo sapiens_hsa04122	0.93235542
43	Cholinergic synapse_Homo sapiens_hsa04725	0.91977089
44	Mismatch repair_Homo sapiens_hsa03430	0.91953069
45	Oocyte meiosis_Homo sapiens_hsa04114	0.86361244
46	Long-term depression_Homo sapiens_hsa04730	0.85957480
47	p53 signaling pathway_Homo sapiens_hsa04115	0.85368436
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.83518113
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83476570
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81571439
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80602146
52	Notch signaling pathway_Homo sapiens_hsa04330	0.79711950
53	Alcoholism_Homo sapiens_hsa05034	0.78014017
54	Parkinsons disease_Homo sapiens_hsa05012	0.74368223
55	Wnt signaling pathway_Homo sapiens_hsa04310	0.72177139
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70705239
57	Peroxisome_Homo sapiens_hsa04146	0.69532389
58	Huntingtons disease_Homo sapiens_hsa05016	0.69196736
59	Cocaine addiction_Homo sapiens_hsa05030	0.67289990
60	Amphetamine addiction_Homo sapiens_hsa05031	0.63794291
61	Adherens junction_Homo sapiens_hsa04520	0.63762461
62	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.63235676
63	Cell cycle_Homo sapiens_hsa04110	0.62807278
64	Colorectal cancer_Homo sapiens_hsa05210	0.60426709
65	Serotonergic synapse_Homo sapiens_hsa04726	0.60277578
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.57593962
67	Spliceosome_Homo sapiens_hsa03040	0.57373379
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.56967105
69	Phototransduction_Homo sapiens_hsa04744	0.56456613
70	Thyroid cancer_Homo sapiens_hsa05216	0.54638802
71	Tight junction_Homo sapiens_hsa04530	0.53939374
72	Base excision repair_Homo sapiens_hsa03410	0.52855341
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52790147
74	RNA transport_Homo sapiens_hsa03013	0.52740794
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.52652382
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52096111
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51975366
78	Oxidative phosphorylation_Homo sapiens_hsa00190	0.51340499
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51081174
80	MicroRNAs in cancer_Homo sapiens_hsa05206	0.49148209
81	Gap junction_Homo sapiens_hsa04540	0.48651071
82	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.47448757
83	Circadian rhythm_Homo sapiens_hsa04710	0.45908060
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45519877
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44280943
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44128235
87	Ras signaling pathway_Homo sapiens_hsa04014	0.43163915
88	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.42273804
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41514305
90	Insulin secretion_Homo sapiens_hsa04911	0.40362381
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40285133
92	Olfactory transduction_Homo sapiens_hsa04740	0.40213479
93	Pathways in cancer_Homo sapiens_hsa05200	0.39528879
94	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39493987
95	Alzheimers disease_Homo sapiens_hsa05010	0.39219260
96	Fatty acid degradation_Homo sapiens_hsa00071	0.39107242
97	Metabolic pathways_Homo sapiens_hsa01100	0.38583091
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35476797
99	Long-term potentiation_Homo sapiens_hsa04720	0.35279063
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.35060730

PCDHB17P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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