PCDHB18P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.89247538
2central nervous system projection neuron axonogenesis (GO:0021952)4.86909298
3neuronal action potential propagation (GO:0019227)4.50245044
4postsynaptic membrane organization (GO:0001941)4.47382616
5cell migration in hindbrain (GO:0021535)4.29418124
6neuron cell-cell adhesion (GO:0007158)4.18074236
7presynaptic membrane organization (GO:0097090)4.15091031
8central nervous system neuron axonogenesis (GO:0021955)4.08400951
9axonal fasciculation (GO:0007413)3.97487187
10positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.64396128
11cerebral cortex radially oriented cell migration (GO:0021799)3.60314025
12microtubule depolymerization (GO:0007019)3.58513109
13synapse assembly (GO:0007416)3.55895256
14regulation of timing of cell differentiation (GO:0048505)3.54142714
15gamma-aminobutyric acid transport (GO:0015812)3.52770501
16regulation of sarcomere organization (GO:0060297)3.48077266
17regulation of development, heterochronic (GO:0040034)3.46763871
18auditory behavior (GO:0031223)3.43851258
19pyrimidine nucleobase catabolic process (GO:0006208)3.42971507
20limb bud formation (GO:0060174)3.41020543
21neuron recognition (GO:0008038)3.40396472
22calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.27110059
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.22233489
24protein polyglutamylation (GO:0018095)3.21548105
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17262561
26neurotransmitter-gated ion channel clustering (GO:0072578)3.14932199
27cochlea development (GO:0090102)3.14692883
28negative regulation of astrocyte differentiation (GO:0048712)3.14449564
29protein localization to synapse (GO:0035418)3.14021432
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12744753
31dendrite development (GO:0016358)3.07992627
32synaptic transmission, glutamatergic (GO:0035249)3.07656722
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03646251
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01646703
35vocalization behavior (GO:0071625)3.01125641
36glutamate receptor signaling pathway (GO:0007215)2.99134120
37adult walking behavior (GO:0007628)2.95544208
38head development (GO:0060322)2.95536648
39regulation of collateral sprouting (GO:0048670)2.93923037
40negative regulation of dendrite development (GO:2000171)2.88795364
41positive regulation of action potential (GO:0045760)2.88599492
42retinal ganglion cell axon guidance (GO:0031290)2.88040050
43regulation of neuron projection regeneration (GO:0070570)2.85393447
44regulation of axon regeneration (GO:0048679)2.85393447
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85335838
46dendrite morphogenesis (GO:0048813)2.84396088
47neuronal ion channel clustering (GO:0045161)2.82621256
48innervation (GO:0060384)2.81583002
49olfactory bulb development (GO:0021772)2.80984877
50axonogenesis (GO:0007409)2.80717066
51homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.80232952
52synapse organization (GO:0050808)2.79595096
53nonmotile primary cilium assembly (GO:0035058)2.78341072
54anatomical structure arrangement (GO:0048532)2.75959256
55negative regulation of glial cell differentiation (GO:0045686)2.73138803
56mechanosensory behavior (GO:0007638)2.70864166
57regulation of synaptic transmission, glutamatergic (GO:0051966)2.70042950
58axon extension (GO:0048675)2.68183678
59acrosome reaction (GO:0007340)2.66492090
60synaptic vesicle maturation (GO:0016188)2.61584859
61regulation of axon guidance (GO:1902667)2.61023297
62membrane depolarization during action potential (GO:0086010)2.60520881
63Notch signaling involved in heart development (GO:0061314)2.60303166
64nucleobase catabolic process (GO:0046113)2.59458253
65detection of light stimulus involved in sensory perception (GO:0050962)2.57988034
66detection of light stimulus involved in visual perception (GO:0050908)2.57988034
67hippocampus development (GO:0021766)2.57945033
68regulation of axon extension involved in axon guidance (GO:0048841)2.57767197
69somite development (GO:0061053)2.56831219
70response to auditory stimulus (GO:0010996)2.56471847
71neuron-neuron synaptic transmission (GO:0007270)2.55876489
72neuromuscular synaptic transmission (GO:0007274)2.54865675
73tachykinin receptor signaling pathway (GO:0007217)2.53860246
74positive regulation of potassium ion transmembrane transport (GO:1901381)2.53797224
75transmission of nerve impulse (GO:0019226)2.53576777
76neuron migration (GO:0001764)2.52977464
77behavioral response to nicotine (GO:0035095)2.52023231
78intraciliary transport (GO:0042073)2.51237040
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50726563
80heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.49769899
81negative regulation of axon extension (GO:0030517)2.48969148
82sympathetic nervous system development (GO:0048485)2.48767744
83neuronal action potential (GO:0019228)2.48135791
84cerebral cortex cell migration (GO:0021795)2.48051527
85cell-cell adhesion (GO:0098609)2.46120783
86hindbrain development (GO:0030902)2.45788959
87cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.45122592
88positive regulation of cardiac muscle cell differentiation (GO:2000727)2.44824673
89atrial cardiac muscle cell action potential (GO:0086014)2.44065411
90positive regulation of synapse assembly (GO:0051965)2.42037285
91negative regulation of oligodendrocyte differentiation (GO:0048715)2.39480803
92negative regulation of gliogenesis (GO:0014014)2.38036443
93negative chemotaxis (GO:0050919)2.36920637
94prepulse inhibition (GO:0060134)2.36380019
95ephrin receptor signaling pathway (GO:0048013)2.36073999
96startle response (GO:0001964)2.34009816
97regulation of synaptic vesicle exocytosis (GO:2000300)2.33420733
98cerebellar Purkinje cell layer development (GO:0021680)2.32665793
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32532454
100regulation of synapse assembly (GO:0051963)2.32045082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.16626760
2GBX2_23144817_ChIP-Seq_PC3_Human3.43721057
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.33375421
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06849151
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92843718
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78949458
7ZNF274_21170338_ChIP-Seq_K562_Hela2.76029861
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.64259670
9TAF15_26573619_Chip-Seq_HEK293_Human2.44902158
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40442185
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38355332
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.32924640
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31612577
14FUS_26573619_Chip-Seq_HEK293_Human2.28850195
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26540471
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.11044040
17P300_19829295_ChIP-Seq_ESCs_Human2.10965900
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07455919
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99093621
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.94654458
21SMAD4_21799915_ChIP-Seq_A2780_Human1.88433045
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87896765
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85748334
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.85225295
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85136810
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78561218
27AR_21572438_ChIP-Seq_LNCaP_Human1.77070802
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69785224
29IGF1R_20145208_ChIP-Seq_DFB_Human1.68473325
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68452070
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.67575703
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.65352756
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65150429
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64634924
35RNF2_27304074_Chip-Seq_NSC_Mouse1.63511668
36REST_21632747_ChIP-Seq_MESCs_Mouse1.63013070
37EWS_26573619_Chip-Seq_HEK293_Human1.59234639
38VDR_22108803_ChIP-Seq_LS180_Human1.58677152
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56621812
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54677958
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53402935
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.52513859
43AR_25329375_ChIP-Seq_VCAP_Human1.50714947
44DROSHA_22980978_ChIP-Seq_HELA_Human1.49871113
45STAT3_23295773_ChIP-Seq_U87_Human1.46707185
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44888853
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43398183
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42395853
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42243188
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42144197
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41175453
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.38687933
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38145247
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37156467
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37156467
56ER_23166858_ChIP-Seq_MCF-7_Human1.35349474
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.34828793
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33176892
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.32760316
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32611794
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32430007
62CBP_20019798_ChIP-Seq_JUKART_Human1.32430007
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31896418
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30087981
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.28559953
66TCF4_23295773_ChIP-Seq_U87_Human1.28020230
67AHR_22903824_ChIP-Seq_MCF-7_Human1.27896659
68RUNX2_22187159_ChIP-Seq_PCA_Human1.27211967
69TP53_18474530_ChIP-ChIP_U2OS_Human1.26584853
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26126635
71SOX9_26525672_Chip-Seq_HEART_Mouse1.24596695
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23674334
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.22583806
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21958407
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21904374
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21904374
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20935498
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19914968
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18570106
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17670974
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17113532
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16717895
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16483223
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15087533
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.14406659
86KDM2B_26808549_Chip-Seq_REH_Human1.13355366
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12552819
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11605536
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09889336
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09513117
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.08006074
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07543827
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07124871
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06777049
95RXR_22108803_ChIP-Seq_LS180_Human1.06619607
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.06302382
97AR_19668381_ChIP-Seq_PC3_Human1.05979430
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.05861157
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04870539
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04841762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.47547769
2MP0004270_analgesia3.28561142
3MP0003880_abnormal_central_pattern2.99800895
4MP0000778_abnormal_nervous_system2.78054759
5MP0004859_abnormal_synaptic_plasticity2.50647074
6MP0002735_abnormal_chemical_nociception2.33435917
7MP0003635_abnormal_synaptic_transmissio2.28632137
8MP0005187_abnormal_penis_morphology2.23695537
9MP0001299_abnormal_eye_distance/2.13601348
10MP0009046_muscle_twitch2.10384926
11MP0002734_abnormal_mechanical_nocicepti2.06595774
12MP0003136_yellow_coat_color1.99080826
13MP0002234_abnormal_pharynx_morphology1.86960782
14MP0001968_abnormal_touch/_nociception1.85647566
15MP0002063_abnormal_learning/memory/cond1.84402152
16MP0002572_abnormal_emotion/affect_behav1.80970122
17MP0000566_synostosis1.80284417
18MP0001529_abnormal_vocalization1.78385178
19MP0001486_abnormal_startle_reflex1.78169657
20MP0009745_abnormal_behavioral_response1.78009575
21MP0002272_abnormal_nervous_system1.73304756
22MP0002736_abnormal_nociception_after1.71519460
23MP0002938_white_spotting1.69132281
24MP0002067_abnormal_sensory_capabilities1.64347242
25MP0002184_abnormal_innervation1.61383610
26MP0002064_seizures1.60251519
27MP0000516_abnormal_urinary_system1.53173369
28MP0005367_renal/urinary_system_phenotyp1.53173369
29MP0001984_abnormal_olfaction1.49264693
30MP0006276_abnormal_autonomic_nervous1.48264806
31MP0000631_abnormal_neuroendocrine_gland1.45569618
32MP0003567_abnormal_fetal_cardiomyocyte1.45383937
33MP0000049_abnormal_middle_ear1.45223112
34MP0003787_abnormal_imprinting1.45145435
35MP0000955_abnormal_spinal_cord1.43842958
36MP0002751_abnormal_autonomic_nervous1.43722463
37MP0004742_abnormal_vestibular_system1.40538196
38MP0002882_abnormal_neuron_morphology1.39896017
39MP0005551_abnormal_eye_electrophysiolog1.39586378
40MP0003861_abnormal_nervous_system1.32661233
41MP0003755_abnormal_palate_morphology1.32169710
42MP0002152_abnormal_brain_morphology1.30795771
43MP0004811_abnormal_neuron_physiology1.30673610
44MP0002102_abnormal_ear_morphology1.27093866
45MP0002653_abnormal_ependyma_morphology1.27043715
46MP0000534_abnormal_ureter_morphology1.25459899
47MP0006072_abnormal_retinal_apoptosis1.25263001
48MP0001485_abnormal_pinna_reflex1.24765408
49MP0000537_abnormal_urethra_morphology1.23143623
50MP0001502_abnormal_circadian_rhythm1.23023124
51MP0004924_abnormal_behavior1.22530532
52MP0005386_behavior/neurological_phenoty1.22530532
53MP0002822_catalepsy1.21230739
54MP0002557_abnormal_social/conspecific_i1.20698293
55MP0005423_abnormal_somatic_nervous1.18734983
56MP0002752_abnormal_somatic_nervous1.18510562
57MP0003937_abnormal_limbs/digits/tail_de1.17815633
58MP0010386_abnormal_urinary_bladder1.17720441
59MP0003868_abnormal_feces_composition1.17535187
60MP0003385_abnormal_body_wall1.14757035
61MP0009384_cardiac_valve_regurgitation1.14630043
62MP0004133_heterotaxia1.13399394
63MP0001970_abnormal_pain_threshold1.11406468
64MP0002733_abnormal_thermal_nociception1.10016038
65MP0008569_lethality_at_weaning1.09528954
66MP0004885_abnormal_endolymph1.08595704
67MP0003935_abnormal_craniofacial_develop1.08526871
68MP0003890_abnormal_embryonic-extraembry1.07796680
69MP0001440_abnormal_grooming_behavior1.06532484
70MP0002233_abnormal_nose_morphology1.06395072
71MP0005253_abnormal_eye_physiology1.05333614
72MP0003942_abnormal_urinary_system1.05022237
73MP0000026_abnormal_inner_ear1.03252736
74MP0002066_abnormal_motor_capabilities/c1.02618321
75MP0003121_genomic_imprinting1.02566491
76MP0000647_abnormal_sebaceous_gland1.00519014
77MP0003315_abnormal_perineum_morphology1.00022178
78MP0004145_abnormal_muscle_electrophysio0.99385432
79MP0001963_abnormal_hearing_physiology0.96149437
80MP0008789_abnormal_olfactory_epithelium0.95475351
81MP0008877_abnormal_DNA_methylation0.95253452
82MP0003122_maternal_imprinting0.93606149
83MP0001177_atelectasis0.91988118
84MP0005499_abnormal_olfactory_system0.90711658
85MP0005394_taste/olfaction_phenotype0.90711658
86MP0002116_abnormal_craniofacial_bone0.90563315
87MP0001346_abnormal_lacrimal_gland0.88204413
88MP0005195_abnormal_posterior_eye0.86193798
89MP0003633_abnormal_nervous_system0.85764395
90MP0003631_nervous_system_phenotype0.82564693
91MP0009703_decreased_birth_body0.81726483
92MP0005391_vision/eye_phenotype0.81270582
93MP0002081_perinatal_lethality0.79575743
94MP0005248_abnormal_Harderian_gland0.79390211
95MP0005645_abnormal_hypothalamus_physiol0.79280491
96MP0004142_abnormal_muscle_tone0.79188044
97MP0005503_abnormal_tendon_morphology0.78951269
98MP0003632_abnormal_nervous_system0.78412600
99MP0003137_abnormal_impulse_conducting0.78366426
100MP0002697_abnormal_eye_size0.78152498

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.58818312
2Focal motor seizures (HP:0011153)4.13226441
3Epileptic encephalopathy (HP:0200134)3.47543235
4Febrile seizures (HP:0002373)3.41287816
5Drooling (HP:0002307)3.34421694
6Progressive cerebellar ataxia (HP:0002073)3.14334553
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09672447
8Short 4th metacarpal (HP:0010044)3.09672447
9Intestinal atresia (HP:0011100)3.07841113
10Absent speech (HP:0001344)3.05074754
11Excessive salivation (HP:0003781)3.03854057
12Abnormality of midbrain morphology (HP:0002418)3.03299093
13Molar tooth sign on MRI (HP:0002419)3.03299093
14Gait imbalance (HP:0002141)2.98542133
15Atonic seizures (HP:0010819)2.93316559
16Chronic hepatic failure (HP:0100626)2.92942921
17Broad-based gait (HP:0002136)2.90122662
18Focal seizures (HP:0007359)2.86953757
19Nephronophthisis (HP:0000090)2.85757334
20Protruding tongue (HP:0010808)2.83881647
21True hermaphroditism (HP:0010459)2.82497449
22Nephrogenic diabetes insipidus (HP:0009806)2.69724879
23Vaginal atresia (HP:0000148)2.66424936
24Genital tract atresia (HP:0001827)2.62923961
25Medial flaring of the eyebrow (HP:0010747)2.57669488
26Congenital primary aphakia (HP:0007707)2.57295816
27Septo-optic dysplasia (HP:0100842)2.54958039
28Midline defect of the nose (HP:0004122)2.51460834
29Fair hair (HP:0002286)2.49324607
30Occipital encephalocele (HP:0002085)2.47013104
31Gaze-evoked nystagmus (HP:0000640)2.45714682
32Septate vagina (HP:0001153)2.44839652
33Pancreatic fibrosis (HP:0100732)2.42269832
34Abnormality of the renal medulla (HP:0100957)2.40495686
35Hypsarrhythmia (HP:0002521)2.37664788
36Optic nerve hypoplasia (HP:0000609)2.35010135
37EEG with generalized epileptiform discharges (HP:0011198)2.34995433
38Lissencephaly (HP:0001339)2.34328250
39Exotropia (HP:0000577)2.33992623
40Epileptiform EEG discharges (HP:0011182)2.33549010
41Narrow forehead (HP:0000341)2.31978177
42Abnormality of the ischium (HP:0003174)2.27674910
43Dialeptic seizures (HP:0011146)2.25435917
44Abnormality of the 4th metacarpal (HP:0010012)2.24284860
45Inability to walk (HP:0002540)2.22442409
46Pancreatic cysts (HP:0001737)2.19965216
47Hemiparesis (HP:0001269)2.19361160
48Glioma (HP:0009733)2.19128053
49Truncal ataxia (HP:0002078)2.18851182
50Absence seizures (HP:0002121)2.14904733
51Hypoplastic ischia (HP:0003175)2.06503888
52Rectovaginal fistula (HP:0000143)2.05135149
53Rectal fistula (HP:0100590)2.05135149
54Neoplasm of the heart (HP:0100544)2.04772099
55Volvulus (HP:0002580)2.03059467
56Gastrointestinal atresia (HP:0002589)2.02835024
57Limb dystonia (HP:0002451)2.01014387
58Generalized hypopigmentation of hair (HP:0011358)1.97461470
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96940016
60Genetic anticipation (HP:0003743)1.96695595
61Astrocytoma (HP:0009592)1.96168529
62Abnormality of the astrocytes (HP:0100707)1.96168529
63Neoplasm of the oral cavity (HP:0100649)1.95396652
64Hip dysplasia (HP:0001385)1.88522201
65Shawl scrotum (HP:0000049)1.88518595
66Poor coordination (HP:0002370)1.87355727
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.85700385
68Postaxial hand polydactyly (HP:0001162)1.84955055
69Aplasia/Hypoplasia of the tibia (HP:0005772)1.84077602
70Pachygyria (HP:0001302)1.81958065
71Cystic liver disease (HP:0006706)1.81617714
72Renal hypoplasia (HP:0000089)1.81047073
73Medulloblastoma (HP:0002885)1.79977411
74Aplasia/Hypoplasia of the lens (HP:0008063)1.79529149
75Micropenis (HP:0000054)1.78346208
76Retinal dysplasia (HP:0007973)1.74739003
77Tented upper lip vermilion (HP:0010804)1.74555270
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74385426
79Chorioretinal atrophy (HP:0000533)1.73317777
80Intestinal fistula (HP:0100819)1.72510668
81Hypoplastic nipples (HP:0002557)1.71403388
82Bilateral microphthalmos (HP:0007633)1.71085951
83Abnormality of the labia minora (HP:0012880)1.68880774
84Abnormal hair whorl (HP:0010721)1.68855369
85Inappropriate behavior (HP:0000719)1.68733725
86Thyroid-stimulating hormone excess (HP:0002925)1.68150854
87Intellectual disability, moderate (HP:0002342)1.67491842
88Prolonged QT interval (HP:0001657)1.66165274
89Vitreoretinal degeneration (HP:0000655)1.66108595
90Polyphagia (HP:0002591)1.65321089
91Bony spicule pigmentary retinopathy (HP:0007737)1.64970859
92Rib fusion (HP:0000902)1.64325251
93Short 5th finger (HP:0009237)1.63052649
94Specific learning disability (HP:0001328)1.62952563
95Widely spaced teeth (HP:0000687)1.62249836
96Amyotrophic lateral sclerosis (HP:0007354)1.62187462
97Decreased testicular size (HP:0008734)1.61537540
98Large for gestational age (HP:0001520)1.61196746
99Papillary thyroid carcinoma (HP:0002895)1.60749654
100Cutaneous finger syndactyly (HP:0010554)1.60621695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.09580073
2EPHA43.72145414
3CASK3.67537255
4PNCK3.25902594
5TNIK3.25434912
6MAPK133.23745949
7TIE12.97126712
8MAP3K42.79877277
9EPHA32.69038249
10WNK32.62863277
11MAP2K72.39355065
12MAP4K22.30102639
13NTRK31.99679418
14BCR1.98869935
15STK38L1.73224808
16NTRK21.66178402
17FRK1.53898313
18CSNK1G21.52744238
19CAMK1G1.42270784
20DYRK21.40111596
21BRD41.34281165
22MAPK151.32550489
23CAMKK21.23223766
24CSNK1A1L1.22851716
25GRK11.16409409
26SIK21.15143265
27CSNK1G31.13522466
28AKT31.12606350
29PAK31.09098758
30RPS6KA41.07408319
31PKN11.06989118
32FGFR21.01951210
33CSNK1G11.00119575
34DYRK1A0.98875875
35PIK3CA0.98768921
36EPHB20.98340540
37PRKCG0.97498587
38SGK2230.97347958
39SGK4940.97347958
40MAP2K40.94922940
41CDK50.93350404
42SGK20.92661456
43CCNB10.90022713
44BMPR1B0.88430878
45UHMK10.83533812
46DYRK30.83473402
47CAMK2B0.83277702
48CDK180.80912069
49CAMK40.80395783
50CDK150.80370740
51MINK10.78811410
52INSRR0.77917509
53PAK60.76895027
54CAMK1D0.76786425
55ERBB30.76526816
56PHKG10.75799526
57PHKG20.75799526
58CDK11A0.74609496
59PRKCE0.74136086
60MKNK20.73606602
61STK380.73407380
62LATS20.72469805
63ADRBK20.71299826
64FER0.70541291
65CAMK2A0.69323111
66LATS10.66300087
67CDK140.64882585
68TSSK60.63237053
69PTK2B0.62839437
70KSR10.62657313
71DYRK1B0.62038991
72CAMK10.57468063
73ERBB20.55865926
74CSNK1D0.52962463
75CSNK1A10.50815261
76TYRO30.50581614
77PRKD30.50347825
78TRIM280.49954257
79DAPK20.49855503
80OXSR10.46691204
81PRKCZ0.44569414
82DDR20.44416513
83PRKACB0.43317354
84CAMK2G0.41983322
85GSK3B0.41495901
86SGK30.40213667
87PRKAA10.40209621
88MAPK80.40199474
89MAPK100.38971232
90RPS6KA30.37733481
91MAP3K60.36470156
92NTRK10.36177236
93CDK30.36140939
94TAOK10.35950296
95MARK20.35516245
96ROCK10.34256226
97MKNK10.31499430
98CSNK1E0.31300187
99PRKACA0.30605008
100FGFR10.30393860

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.39837984
2Taste transduction_Homo sapiens_hsa047422.70150728
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66508050
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55961954
5Glutamatergic synapse_Homo sapiens_hsa047242.50734034
6GABAergic synapse_Homo sapiens_hsa047272.42318686
7Morphine addiction_Homo sapiens_hsa050322.28127404
8Circadian entrainment_Homo sapiens_hsa047132.10125291
9Cocaine addiction_Homo sapiens_hsa050301.99011969
10Phototransduction_Homo sapiens_hsa047441.97664032
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91734318
12Axon guidance_Homo sapiens_hsa043601.90027737
13Dopaminergic synapse_Homo sapiens_hsa047281.84256854
14Amphetamine addiction_Homo sapiens_hsa050311.72718062
15Long-term depression_Homo sapiens_hsa047301.58594325
16Insulin secretion_Homo sapiens_hsa049111.46501239
17Olfactory transduction_Homo sapiens_hsa047401.36137293
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31151212
19Cholinergic synapse_Homo sapiens_hsa047251.29971800
20Salivary secretion_Homo sapiens_hsa049701.29867994
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28429332
22Synaptic vesicle cycle_Homo sapiens_hsa047211.26047756
23Renin secretion_Homo sapiens_hsa049241.23547460
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23398864
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22599240
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21326160
27Calcium signaling pathway_Homo sapiens_hsa040201.18506117
28Butanoate metabolism_Homo sapiens_hsa006501.17942562
29cAMP signaling pathway_Homo sapiens_hsa040241.17058058
30Circadian rhythm_Homo sapiens_hsa047101.15725090
31Serotonergic synapse_Homo sapiens_hsa047261.13909424
32Nitrogen metabolism_Homo sapiens_hsa009101.12563590
33Basal cell carcinoma_Homo sapiens_hsa052171.11818889
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10849379
35Fatty acid biosynthesis_Homo sapiens_hsa000611.10474596
36Ether lipid metabolism_Homo sapiens_hsa005651.09965591
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07219347
38Dilated cardiomyopathy_Homo sapiens_hsa054141.06582969
39Hippo signaling pathway_Homo sapiens_hsa043901.05755994
40Gap junction_Homo sapiens_hsa045401.02388334
41Oxytocin signaling pathway_Homo sapiens_hsa049211.01759241
42Gastric acid secretion_Homo sapiens_hsa049711.00602618
43Selenocompound metabolism_Homo sapiens_hsa004501.00272336
44Hedgehog signaling pathway_Homo sapiens_hsa043400.95865125
45Lysine degradation_Homo sapiens_hsa003100.95553545
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95086424
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94725363
48Estrogen signaling pathway_Homo sapiens_hsa049150.93772654
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89507143
50Long-term potentiation_Homo sapiens_hsa047200.87719020
51Type II diabetes mellitus_Homo sapiens_hsa049300.83502521
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82805727
53Linoleic acid metabolism_Homo sapiens_hsa005910.82750350
54Notch signaling pathway_Homo sapiens_hsa043300.82250631
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78791681
56Melanogenesis_Homo sapiens_hsa049160.77255589
57Cardiac muscle contraction_Homo sapiens_hsa042600.74301456
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71085260
59TGF-beta signaling pathway_Homo sapiens_hsa043500.70457071
60MAPK signaling pathway_Homo sapiens_hsa040100.70150832
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.69679948
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68434501
63Melanoma_Homo sapiens_hsa052180.68135800
64Basal transcription factors_Homo sapiens_hsa030220.67417694
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67271339
66Regulation of autophagy_Homo sapiens_hsa041400.65218772
67Tight junction_Homo sapiens_hsa045300.64912831
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64661901
69ErbB signaling pathway_Homo sapiens_hsa040120.63031632
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62737419
71Propanoate metabolism_Homo sapiens_hsa006400.62557554
72Colorectal cancer_Homo sapiens_hsa052100.61255345
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60848029
74Alcoholism_Homo sapiens_hsa050340.60816896
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60727995
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59090273
77Rap1 signaling pathway_Homo sapiens_hsa040150.58111750
78ABC transporters_Homo sapiens_hsa020100.57309334
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56056353
80Ras signaling pathway_Homo sapiens_hsa040140.54401024
81Fanconi anemia pathway_Homo sapiens_hsa034600.53504243
82Steroid biosynthesis_Homo sapiens_hsa001000.52855340
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52854117
84Ovarian steroidogenesis_Homo sapiens_hsa049130.52446184
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51382376
86Choline metabolism in cancer_Homo sapiens_hsa052310.51262987
87ECM-receptor interaction_Homo sapiens_hsa045120.51183691
88Protein digestion and absorption_Homo sapiens_hsa049740.49715714
89Oocyte meiosis_Homo sapiens_hsa041140.49596629
90AMPK signaling pathway_Homo sapiens_hsa041520.49533531
91Wnt signaling pathway_Homo sapiens_hsa043100.49191771
92Thyroid hormone synthesis_Homo sapiens_hsa049180.48683984
93beta-Alanine metabolism_Homo sapiens_hsa004100.47583084
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47354608
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47025527
96Endometrial cancer_Homo sapiens_hsa052130.46771576
97Pancreatic secretion_Homo sapiens_hsa049720.46064959
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45278771
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.44603211
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42845596

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