ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	7.38083759
2	fucose catabolic process (GO:0019317)	6.20521318
3	L-fucose metabolic process (GO:0042354)	6.20521318
4	L-fucose catabolic process (GO:0042355)	6.20521318
5	activated T cell proliferation (GO:0050798)	5.18790237
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.76945365
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.76945365
8	positive regulation of catecholamine secretion (GO:0033605)	4.61288550
9	behavioral response to nicotine (GO:0035095)	4.58498859
10	negative regulation of membrane potential (GO:0045837)	4.10979551
11	cardiac left ventricle morphogenesis (GO:0003214)	4.09609166
12	fucosylation (GO:0036065)	4.04087099
13	acrosome reaction (GO:0007340)	3.97398958
14	regulation of feeding behavior (GO:0060259)	3.79039974
15	regulation of dopamine secretion (GO:0014059)	3.78338931
16	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.75580579
17	transmission of nerve impulse (GO:0019226)	3.71773072
18	peristalsis (GO:0030432)	3.69368076
19	mechanosensory behavior (GO:0007638)	3.61096868
20	indolalkylamine metabolic process (GO:0006586)	3.56851914
21	behavioral response to ethanol (GO:0048149)	3.56392978
22	kynurenine metabolic process (GO:0070189)	3.55526673
23	negative regulation of neurological system process (GO:0031645)	3.53441528
24	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.33657996
25	substrate-independent telencephalic tangential migration (GO:0021826)	3.33657996
26	viral transcription (GO:0019083)	3.32259935
27	negative regulation of Rho protein signal transduction (GO:0035024)	3.30772301
28	sequestering of actin monomers (GO:0042989)	3.25555901
29	retinal ganglion cell axon guidance (GO:0031290)	3.22499461
30	positive regulation of fatty acid oxidation (GO:0046321)	3.20596850
31	translational termination (GO:0006415)	3.18951414
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11476176
33	platelet dense granule organization (GO:0060155)	3.02413985
34	response to histamine (GO:0034776)	3.00904244
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.00280413
36	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	2.97135728
37	regulation of circadian sleep/wake cycle (GO:0042749)	2.97135728
38	tryptophan catabolic process (GO:0006569)	2.95129394
39	indole-containing compound catabolic process (GO:0042436)	2.95129394
40	indolalkylamine catabolic process (GO:0046218)	2.95129394
41	inner ear receptor cell development (GO:0060119)	2.94315962
42	somite development (GO:0061053)	2.91903217
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91842909
44	NADH dehydrogenase complex assembly (GO:0010257)	2.91842909
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91842909
46	inositol phosphate dephosphorylation (GO:0046855)	2.89334840
47	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.89334840
48	nonmotile primary cilium assembly (GO:0035058)	2.88813612
49	nitric oxide mediated signal transduction (GO:0007263)	2.87067735
50	regulation of action potential (GO:0098900)	2.86423998
51	cotranslational protein targeting to membrane (GO:0006613)	2.86310594
52	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.86240562
53	G-protein coupled receptor internalization (GO:0002031)	2.85585061
54	positive regulation of amine transport (GO:0051954)	2.85418864
55	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.85268012
56	inositol phosphate catabolic process (GO:0071545)	2.84498709
57	sulfation (GO:0051923)	2.84256721
58	respiratory chain complex IV assembly (GO:0008535)	2.83362095
59	positive regulation of fatty acid transport (GO:2000193)	2.81546856
60	regulation of hexokinase activity (GO:1903299)	2.81336369
61	regulation of glucokinase activity (GO:0033131)	2.81336369
62	inositol metabolic process (GO:0006020)	2.79554256
63	phasic smooth muscle contraction (GO:0014821)	2.79427990
64	protein targeting to ER (GO:0045047)	2.78722327
65	positive regulation of action potential (GO:0045760)	2.78190674
66	valine metabolic process (GO:0006573)	2.75103693
67	epithelial cilium movement (GO:0003351)	2.74998367
68	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.74572852
69	fucose metabolic process (GO:0006004)	2.73000766
70	protein complex biogenesis (GO:0070271)	2.72856014
71	tRNA processing (GO:0008033)	2.72585082
72	neuron fate determination (GO:0048664)	2.72055597
73	intraciliary transport (GO:0042073)	2.71942818
74	startle response (GO:0001964)	2.68264982
75	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.68185943
76	negative regulation of mast cell activation (GO:0033004)	2.66716074
77	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.66287303
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.63796135
79	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.62735158
80	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.62726488
81	auditory behavior (GO:0031223)	2.61956271
82	protein-cofactor linkage (GO:0018065)	2.60551938
83	pseudouridine synthesis (GO:0001522)	2.59497299
84	behavioral defense response (GO:0002209)	2.58635379
85	behavioral fear response (GO:0001662)	2.58635379
86	regulation of meiosis I (GO:0060631)	2.58549254
87	protein localization to endoplasmic reticulum (GO:0070972)	2.58019775
88	protein targeting to lysosome (GO:0006622)	2.57129946
89	establishment of protein localization to vacuole (GO:0072666)	2.57129946
90	protein targeting to vacuole (GO:0006623)	2.57129946
91	indole-containing compound metabolic process (GO:0042430)	2.56143157
92	axoneme assembly (GO:0035082)	2.55611321
93	positive regulation of smooth muscle contraction (GO:0045987)	2.55314476
94	ribosomal small subunit biogenesis (GO:0042274)	2.53139984
95	regulation of sensory perception of pain (GO:0051930)	2.53026335
96	regulation of sensory perception (GO:0051931)	2.53026335
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.53017635
98	cell proliferation in forebrain (GO:0021846)	2.52679297
99	striatum development (GO:0021756)	2.52476853
100	translational elongation (GO:0006414)	2.50769213

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.80237933
2	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.29443896
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.28631718
4	VDR_22108803_ChIP-Seq_LS180_Human	3.25245645
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.92979053
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.72106632
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.58286495
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.48677245
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38051858
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.34466246
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21683107
12	FUS_26573619_Chip-Seq_HEK293_Human	2.17974893
13	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	2.16448570
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10060214
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.02701185
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01178996
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.01047654
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96730112
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94952498
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93599924
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.92999687
22	EWS_26573619_Chip-Seq_HEK293_Human	1.87803483
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80230222
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74706182
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71095901
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.68245302
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67664232
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.66543563
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66265375
30	P300_19829295_ChIP-Seq_ESCs_Human	1.65768246
31	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65517193
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63402006
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.61317945
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.60589345
35	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.59591995
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.57971086
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55092113
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.55092113
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53757990
40	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.50161886
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48774242
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.44806047
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44402621
44	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.43207197
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41711669
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40906208
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.40463796
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39329583
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39039676
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38235105
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37757919
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36550339
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35251741
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.34087105
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33479907
56	TCF4_23295773_ChIP-Seq_U87_Human	1.33475144
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32842308
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30427865
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30321491
60	STAT3_23295773_ChIP-Seq_U87_Human	1.29889644
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28001903
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26359851
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26159325
64	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26010339
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20393548
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19860031
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18320086
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18309673
69	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17476022
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15785134
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13647029
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13615678
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13332094
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12383312
75	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12249386
76	AR_25329375_ChIP-Seq_VCAP_Human	1.09590893
77	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09400647
78	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08960540
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08630478
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08529551
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08324018
82	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.07915816
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07844199
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05945451
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04769017
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03553507
87	TCF4_22108803_ChIP-Seq_LS180_Human	1.03391968
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03342764
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02086341
90	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01977025
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01483825
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01227107
93	AR_20517297_ChIP-Seq_VCAP_Human	1.01155396
94	MYC_19829295_ChIP-Seq_ESCs_Human	1.01114754
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00586035
96	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00359609
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98162482
98	NCOR_22424771_ChIP-Seq_293T_Human	0.98087832
99	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.97637832
100	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97376034

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.88915769
2	MP0001188_hyperpigmentation	3.48981754
3	MP0002638_abnormal_pupillary_reflex	3.26784199
4	MP0006292_abnormal_olfactory_placode	2.61148536
5	MP0010030_abnormal_orbit_morphology	2.42342883
6	MP0005646_abnormal_pituitary_gland	2.25609075
7	MP0002102_abnormal_ear_morphology	2.14967894
8	MP0005084_abnormal_gallbladder_morpholo	2.13142539
9	MP0004885_abnormal_endolymph	2.13028441
10	MP0005187_abnormal_penis_morphology	2.11288134
11	MP0005248_abnormal_Harderian_gland	1.99943407
12	MP0005551_abnormal_eye_electrophysiolog	1.95072010
13	MP0001529_abnormal_vocalization	1.85866787
14	MP0001984_abnormal_olfaction	1.78346712
15	MP0006276_abnormal_autonomic_nervous	1.77482857
16	MP0009384_cardiac_valve_regurgitation	1.72567018
17	MP0001486_abnormal_startle_reflex	1.72469824
18	MP0009745_abnormal_behavioral_response	1.69405467
19	MP0000049_abnormal_middle_ear	1.67848943
20	MP0001501_abnormal_sleep_pattern	1.67738005
21	MP0002138_abnormal_hepatobiliary_system	1.65450165
22	MP0001502_abnormal_circadian_rhythm	1.64192810
23	MP0009053_abnormal_anal_canal	1.63570571
24	MP0008877_abnormal_DNA_methylation	1.63202843
25	MP0002736_abnormal_nociception_after	1.60831522
26	MP0001879_abnormal_lymphatic_vessel	1.60236506
27	MP0006072_abnormal_retinal_apoptosis	1.59219543
28	MP0002653_abnormal_ependyma_morphology	1.57610356
29	MP0000631_abnormal_neuroendocrine_gland	1.57359787
30	MP0003787_abnormal_imprinting	1.55356245
31	MP0008789_abnormal_olfactory_epithelium	1.54819661
32	MP0002272_abnormal_nervous_system	1.52260632
33	MP0003195_calcinosis	1.51538528
34	MP0000026_abnormal_inner_ear	1.49484945
35	MP0004133_heterotaxia	1.48942477
36	MP0002837_dystrophic_cardiac_calcinosis	1.45163272
37	MP0002752_abnormal_somatic_nervous	1.44986009
38	MP0000778_abnormal_nervous_system	1.44466263
39	MP0005195_abnormal_posterior_eye	1.44350842
40	MP0000647_abnormal_sebaceous_gland	1.43526951
41	MP0005394_taste/olfaction_phenotype	1.42664384
42	MP0005499_abnormal_olfactory_system	1.42664384
43	MP0003937_abnormal_limbs/digits/tail_de	1.40096874
44	MP0003880_abnormal_central_pattern	1.37976635
45	MP0001968_abnormal_touch/_nociception	1.35273221
46	MP0001286_abnormal_eye_development	1.34809520
47	MP0008775_abnormal_heart_ventricle	1.32006461
48	MP0002938_white_spotting	1.29327520
49	MP0002132_abnormal_respiratory_system	1.29113945
50	MP0002067_abnormal_sensory_capabilities	1.26709901
51	MP0002184_abnormal_innervation	1.26118729
52	MP0002064_seizures	1.25722465
53	MP0001324_abnormal_eye_pigmentation	1.24232969
54	MP0003119_abnormal_digestive_system	1.22687500
55	MP0002572_abnormal_emotion/affect_behav	1.22660050
56	MP0000537_abnormal_urethra_morphology	1.22581336
57	MP0002751_abnormal_autonomic_nervous	1.21414906
58	MP0002557_abnormal_social/conspecific_i	1.19671230
59	MP0005253_abnormal_eye_physiology	1.17603703
60	MP0003942_abnormal_urinary_system	1.17094134
61	MP0002733_abnormal_thermal_nociception	1.13650995
62	MP0002063_abnormal_learning/memory/cond	1.12557754
63	MP0001963_abnormal_hearing_physiology	1.12170317
64	MP0001293_anophthalmia	1.11859987
65	MP0000230_abnormal_systemic_arterial	1.09394914
66	MP0005386_behavior/neurological_phenoty	1.05757118
67	MP0004924_abnormal_behavior	1.05757118
68	MP0002882_abnormal_neuron_morphology	1.04591992
69	MP0003635_abnormal_synaptic_transmissio	1.04451117
70	MP0004742_abnormal_vestibular_system	1.02556073
71	MP0000462_abnormal_digestive_system	1.01708202
72	MP0009379_abnormal_foot_pigmentation	1.01181825
73	MP0003122_maternal_imprinting	0.99581263
74	MP0000383_abnormal_hair_follicle	0.98436043
75	MP0003136_yellow_coat_color	0.96322730
76	MP0004142_abnormal_muscle_tone	0.96295507
77	MP0002928_abnormal_bile_duct	0.95907277
78	MP0001919_abnormal_reproductive_system	0.94108383
79	MP0009046_muscle_twitch	0.91893784
80	MP0004145_abnormal_muscle_electrophysio	0.91373141
81	MP0002735_abnormal_chemical_nociception	0.91252162
82	MP0005423_abnormal_somatic_nervous	0.91220497
83	MP0003011_delayed_dark_adaptation	0.89474445
84	MP0004085_abnormal_heartbeat	0.88870169
85	MP0003186_abnormal_redox_activity	0.87043474
86	MP0002233_abnormal_nose_morphology	0.86416574
87	MP0003698_abnormal_male_reproductive	0.85722749
88	MP0000955_abnormal_spinal_cord	0.85303216
89	MP0001905_abnormal_dopamine_level	0.85085253
90	MP0001270_distended_abdomen	0.84223583
91	MP0001970_abnormal_pain_threshold	0.80660908
92	MP0002152_abnormal_brain_morphology	0.79515463
93	MP0003861_abnormal_nervous_system	0.79331232
94	MP0005645_abnormal_hypothalamus_physiol	0.78759271
95	MP0005389_reproductive_system_phenotype	0.78658821
96	MP0002095_abnormal_skin_pigmentation	0.78386031
97	MP0002876_abnormal_thyroid_physiology	0.78057214
98	MP0000613_abnormal_salivary_gland	0.77127979
99	MP0005391_vision/eye_phenotype	0.74440777
100	MP0002909_abnormal_adrenal_gland	0.72098177

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.85627472
2	Pigmentary retinal degeneration (HP:0001146)	4.00350852
3	Chorioretinal atrophy (HP:0000533)	3.99387002
4	Pendular nystagmus (HP:0012043)	3.88190514
5	Type II lissencephaly (HP:0007260)	3.81432563
6	Pancreatic fibrosis (HP:0100732)	3.41318087
7	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.36578067
8	Abnormality of midbrain morphology (HP:0002418)	3.18886664
9	Molar tooth sign on MRI (HP:0002419)	3.18886664
10	Abnormality of the labia minora (HP:0012880)	3.01961781
11	Medial flaring of the eyebrow (HP:0010747)	2.97748991
12	Cerebellar dysplasia (HP:0007033)	2.97634897
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.94969431
14	Abnormality of alanine metabolism (HP:0010916)	2.94969431
15	Hyperalaninemia (HP:0003348)	2.94969431
16	Retinal dysplasia (HP:0007973)	2.92351715
17	Lissencephaly (HP:0001339)	2.82256837
18	Hypoplasia of the pons (HP:0012110)	2.82242086
19	Nephrogenic diabetes insipidus (HP:0009806)	2.73222191
20	Abnormality of cells of the erythroid lineage (HP:0012130)	2.69672348
21	Pancreatic cysts (HP:0001737)	2.65540794
22	Global brain atrophy (HP:0002283)	2.65222840
23	Gait imbalance (HP:0002141)	2.56298605
24	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.55426196
25	Abnormal drinking behavior (HP:0030082)	2.51745439
26	Polydipsia (HP:0001959)	2.51745439
27	Ectopic kidney (HP:0000086)	2.51551152
28	Congenital primary aphakia (HP:0007707)	2.50596039
29	Abnormality of the pons (HP:0007361)	2.50022773
30	Abnormal number of erythroid precursors (HP:0012131)	2.48854982
31	Rib fusion (HP:0000902)	2.45921171
32	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.44804861
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.32639951
34	Septo-optic dysplasia (HP:0100842)	2.31183461
35	Abnormality of the parathyroid morphology (HP:0011766)	2.26408931
36	Anencephaly (HP:0002323)	2.22193091
37	Limb dystonia (HP:0002451)	2.21455979
38	Humeroradial synostosis (HP:0003041)	2.20053926
39	Synostosis involving the elbow (HP:0003938)	2.20053926
40	Decreased central vision (HP:0007663)	2.19376231
41	Oligodactyly (hands) (HP:0001180)	2.17422628
42	Genital tract atresia (HP:0001827)	2.16651276
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15898214
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.14919600
45	Vaginal atresia (HP:0000148)	2.13752398
46	Type I diabetes mellitus (HP:0100651)	2.12321594
47	Polyuria (HP:0000103)	2.12187446
48	True hermaphroditism (HP:0010459)	2.11457998
49	Nephronophthisis (HP:0000090)	2.09266914
50	Hepatocellular necrosis (HP:0001404)	2.06831961
51	Optic nerve hypoplasia (HP:0000609)	2.05600833
52	Cutaneous finger syndactyly (HP:0010554)	2.04534613
53	Abnormality of the 4th metacarpal (HP:0010012)	2.01474839
54	Chronic hepatic failure (HP:0100626)	2.00128026
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98598686
56	Reticulocytopenia (HP:0001896)	1.97540683
57	Abnormality of the pubic bones (HP:0003172)	1.97513036
58	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.97181641
59	Hepatoblastoma (HP:0002884)	1.96535662
60	Short tibia (HP:0005736)	1.90924121
61	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.90846269
62	Tubular atrophy (HP:0000092)	1.89913035
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89273957
64	Stenosis of the external auditory canal (HP:0000402)	1.86883578
65	Hyperglycinemia (HP:0002154)	1.84425894
66	Macrocytic anemia (HP:0001972)	1.82092356
67	Abolished electroretinogram (ERG) (HP:0000550)	1.81339050
68	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.81251245
69	Short 1st metacarpal (HP:0010034)	1.81251245
70	Agitation (HP:0000713)	1.79544769
71	Focal motor seizures (HP:0011153)	1.79274558
72	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78725355
73	Abnormality of the renal cortex (HP:0011035)	1.78498260
74	Abnormal urine output (HP:0012590)	1.76848092
75	Attenuation of retinal blood vessels (HP:0007843)	1.75352401
76	Esophageal atresia (HP:0002032)	1.74939042
77	Abnormality of DNA repair (HP:0003254)	1.74863826
78	Poor coordination (HP:0002370)	1.74760709
79	Congenital sensorineural hearing impairment (HP:0008527)	1.73315791
80	Mitochondrial inheritance (HP:0001427)	1.73143328
81	Patellar aplasia (HP:0006443)	1.72668077
82	Pheochromocytoma (HP:0002666)	1.71826265
83	Adactyly (HP:0009776)	1.71577085
84	Increased corneal curvature (HP:0100692)	1.70932456
85	Keratoconus (HP:0000563)	1.70932456
86	Sclerocornea (HP:0000647)	1.70760926
87	Drooling (HP:0002307)	1.70535850
88	Hepatic necrosis (HP:0002605)	1.68910717
89	Abnormality of the renal medulla (HP:0100957)	1.68594957
90	Abnormal ciliary motility (HP:0012262)	1.67500010
91	Hemivertebrae (HP:0002937)	1.66337154
92	Cutaneous syndactyly (HP:0012725)	1.64723624
93	Dyskinesia (HP:0100660)	1.64543328
94	Occipital encephalocele (HP:0002085)	1.61869912
95	Abnormality of the anterior horn cell (HP:0006802)	1.61390061
96	Degeneration of anterior horn cells (HP:0002398)	1.61390061
97	Hypophosphatemic rickets (HP:0004912)	1.61158774
98	Lipid accumulation in hepatocytes (HP:0006561)	1.59313175
99	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.59125255
100	Short phalanx of the thumb (HP:0009660)	1.59010668

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CA	4.36891407
2	ADRBK2	3.44590141
3	FRK	3.16908810
4	BCKDK	2.68282236
5	GRK1	2.66830460
6	MAP3K9	2.51736599
7	TAOK3	2.46908879
8	NUAK1	2.32349224
9	STK39	2.20266619
10	MAPK13	2.14646858
11	PINK1	2.13363037
12	MAP3K4	2.12658987
13	MAP2K7	2.09084285
14	NTRK2	2.03692243
15	PRKD3	1.98190577
16	EPHB2	1.97519679
17	CASK	1.82910153
18	TLK1	1.65998887
19	EPHA3	1.65843907
20	MAP4K2	1.59330755
21	WNK4	1.57715130
22	WNK3	1.50930629
23	TIE1	1.47177456
24	MARK1	1.46964953
25	PASK	1.46200275
26	MAP3K13	1.37697399
27	ADRBK1	1.37453601
28	DYRK3	1.32208664
29	CSNK1G3	1.31001927
30	PLK2	1.25392030
31	CSNK1G1	1.25118188
32	CSNK1G2	1.23701793
33	PRKCG	1.15328678
34	RPS6KA5	1.11628110
35	CSNK1A1L	1.09354199
36	INSRR	1.08885995
37	DYRK2	1.07715453
38	DYRK1B	1.01703769
39	MST4	1.00301173
40	PAK3	0.99307245
41	STK24	0.97968660
42	PRKCE	0.96462098
43	VRK1	0.94362069
44	BRSK2	0.93112651
45	DYRK1A	0.90233966
46	BMPR1B	0.88935620
47	RPS6KA4	0.88853994
48	EPHA4	0.88477446
49	PLK4	0.85446019
50	TGFBR1	0.82989208
51	PTK6	0.82359659
52	CAMKK2	0.78927313
53	TNIK	0.76286632
54	OXSR1	0.74822012
55	BCR	0.73703584
56	STK38L	0.72668372
57	PTK2B	0.70846701
58	IRAK1	0.69868218
59	CAMK2B	0.66969854
60	MAP2K2	0.66856369
61	PRKCI	0.66481269
62	NLK	0.66056349
63	NTRK3	0.63283675
64	CAMK2A	0.62187770
65	DAPK2	0.61085845
66	MAPK15	0.58962607
67	PRKCQ	0.58033286
68	SGK2	0.55763244
69	ACVR1B	0.52818587
70	CLK1	0.51064671
71	ARAF	0.50472349
72	PRKACA	0.50260166
73	CAMK2D	0.49326655
74	DMPK	0.48181329
75	CSNK1A1	0.48090744
76	ERBB2	0.45198978
77	SGK494	0.44273777
78	SGK223	0.44273777
79	CSNK1D	0.44030410
80	FGFR1	0.43618559
81	CAMK2G	0.42670923
82	TXK	0.42387553
83	PRKD2	0.41154857
84	CDK5	0.41034780
85	GRK7	0.38563550
86	MAP2K4	0.38295926
87	RAF1	0.38161130
88	WEE1	0.37692646
89	PRKG1	0.36820994
90	STK3	0.36204894
91	ABL2	0.34671995
92	PKN1	0.32559832
93	PLK1	0.31928920
94	ZAK	0.31735364
95	PHKG2	0.30863573
96	PHKG1	0.30863573
97	PRKCH	0.30743343
98	MOS	0.30396056
99	BRD4	0.30176771
100	KSR1	0.29009124

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.46081190
2	Phototransduction_Homo sapiens_hsa04744	3.43370877
3	Ribosome_Homo sapiens_hsa03010	3.16143931
4	Protein export_Homo sapiens_hsa03060	2.66826174
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.49132716
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46706903
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.35666305
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.29071267
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.15738333
10	Butanoate metabolism_Homo sapiens_hsa00650	2.15385057
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.08061299
12	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.05967227
13	Taste transduction_Homo sapiens_hsa04742	2.00175329
14	Nicotine addiction_Homo sapiens_hsa05033	1.93036210
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.92652845
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86852449
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85674762
18	RNA polymerase_Homo sapiens_hsa03020	1.83681874
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81579789
20	Parkinsons disease_Homo sapiens_hsa05012	1.70206324
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70196702
22	Propanoate metabolism_Homo sapiens_hsa00640	1.69253599
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68372795
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58443215
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49149721
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.37777890
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37373597
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.36448332
29	Basal transcription factors_Homo sapiens_hsa03022	1.35185764
30	Olfactory transduction_Homo sapiens_hsa04740	1.34820718
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25098981
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23683764
33	Huntingtons disease_Homo sapiens_hsa05016	1.20718617
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15227012
35	Serotonergic synapse_Homo sapiens_hsa04726	1.13181279
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08832781
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.08248307
38	Homologous recombination_Homo sapiens_hsa03440	1.07362964
39	Basal cell carcinoma_Homo sapiens_hsa05217	1.05973433
40	Alzheimers disease_Homo sapiens_hsa05010	1.01853507
41	RNA degradation_Homo sapiens_hsa03018	1.01058682
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94637555
43	Cocaine addiction_Homo sapiens_hsa05030	0.91453984
44	Insulin secretion_Homo sapiens_hsa04911	0.89146696
45	Folate biosynthesis_Homo sapiens_hsa00790	0.88653546
46	p53 signaling pathway_Homo sapiens_hsa04115	0.88181852
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83915402
48	RNA transport_Homo sapiens_hsa03013	0.83254435
49	Sulfur metabolism_Homo sapiens_hsa00920	0.83137291
50	Morphine addiction_Homo sapiens_hsa05032	0.82879308
51	GABAergic synapse_Homo sapiens_hsa04727	0.79470983
52	Axon guidance_Homo sapiens_hsa04360	0.78554570
53	Caffeine metabolism_Homo sapiens_hsa00232	0.77812066
54	Purine metabolism_Homo sapiens_hsa00230	0.76886690
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74292625
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71550037
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71360404
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.70488600
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70335803
60	Circadian entrainment_Homo sapiens_hsa04713	0.70138385
61	Circadian rhythm_Homo sapiens_hsa04710	0.66435550
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.65586741
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.64906615
64	Peroxisome_Homo sapiens_hsa04146	0.64510999
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62379283
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62154664
67	Retinol metabolism_Homo sapiens_hsa00830	0.61262941
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61091261
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61054912
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59415916
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57806118
72	Metabolic pathways_Homo sapiens_hsa01100	0.51470171
73	Proteasome_Homo sapiens_hsa03050	0.50442700
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.49984384
75	Fatty acid degradation_Homo sapiens_hsa00071	0.49767834
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49194645
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48511898
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46462219
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45910590
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.45739898
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45584863
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.45110106
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.43345983
84	Mismatch repair_Homo sapiens_hsa03430	0.43073144
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.42918976
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42772805
87	Amphetamine addiction_Homo sapiens_hsa05031	0.41288359
88	Cholinergic synapse_Homo sapiens_hsa04725	0.41022010
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40685141
90	ABC transporters_Homo sapiens_hsa02010	0.39018799
91	Salivary secretion_Homo sapiens_hsa04970	0.38515298
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37546540
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35748994
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35403281
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33183987
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33048198
97	Long-term depression_Homo sapiens_hsa04730	0.32891308
98	Gastric acid secretion_Homo sapiens_hsa04971	0.32444676
99	Regulation of autophagy_Homo sapiens_hsa04140	0.31869145
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30803198

PCDHB19P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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