PCDHB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.99579152
2nucleobase catabolic process (GO:0046113)5.41021458
3neuron cell-cell adhesion (GO:0007158)5.40721151
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34535048
5locomotory exploration behavior (GO:0035641)5.05199075
6vocalization behavior (GO:0071625)4.99765083
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.87118152
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76097015
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.72011705
10negative regulation of synaptic transmission, GABAergic (GO:0032229)4.54745392
11protein localization to synapse (GO:0035418)4.54140400
12synaptic vesicle exocytosis (GO:0016079)4.53282400
13presynaptic membrane assembly (GO:0097105)4.48574905
14glutamate receptor signaling pathway (GO:0007215)4.41491374
15neuron-neuron synaptic transmission (GO:0007270)4.31983687
16gamma-aminobutyric acid transport (GO:0015812)4.31814153
17response to histamine (GO:0034776)4.28732833
18positive regulation of mitochondrial fission (GO:0090141)4.27167473
19exploration behavior (GO:0035640)4.26048105
20glutamate secretion (GO:0014047)4.23948176
21regulation of glutamate receptor signaling pathway (GO:1900449)4.22485192
22behavioral response to cocaine (GO:0048148)4.20992351
23regulation of synaptic vesicle exocytosis (GO:2000300)4.19932564
24neurotransmitter secretion (GO:0007269)4.16467848
25neuron recognition (GO:0008038)4.16172315
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.13104653
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.13083423
28synaptic transmission, glutamatergic (GO:0035249)4.12710033
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.10050597
30presynaptic membrane organization (GO:0097090)4.08903809
31* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.05335275
32establishment of mitochondrion localization (GO:0051654)4.04396825
33synaptic vesicle maturation (GO:0016188)4.03230865
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91723706
35prepulse inhibition (GO:0060134)3.90078064
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89625234
37long-term synaptic potentiation (GO:0060291)3.85325849
38postsynaptic membrane organization (GO:0001941)3.85210469
39retinal ganglion cell axon guidance (GO:0031290)3.80587106
40axonal fasciculation (GO:0007413)3.79956997
41transmission of nerve impulse (GO:0019226)3.77058114
42neurotransmitter-gated ion channel clustering (GO:0072578)3.72188273
43neuronal action potential propagation (GO:0019227)3.71372815
44nonmotile primary cilium assembly (GO:0035058)3.70047805
45regulation of synaptic vesicle transport (GO:1902803)3.67085122
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.66812183
47layer formation in cerebral cortex (GO:0021819)3.65319236
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64508467
49cerebellar granule cell differentiation (GO:0021707)3.59573559
50regulation of neuronal synaptic plasticity (GO:0048168)3.58903649
51striatum development (GO:0021756)3.52522976
52behavioral response to nicotine (GO:0035095)3.52356604
53dendritic spine morphogenesis (GO:0060997)3.50170254
54regulation of postsynaptic membrane potential (GO:0060078)3.47480178
55positive regulation of synapse maturation (GO:0090129)3.47145445
56regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.45226437
57regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.45226437
58regulation of cAMP-dependent protein kinase activity (GO:2000479)3.43475518
59intraciliary transport (GO:0042073)3.40283787
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.36035803
61limb bud formation (GO:0060174)3.35858384
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35768544
63regulation of dendritic spine morphogenesis (GO:0061001)3.31890928
64olfactory bulb development (GO:0021772)3.27975379
65regulation of neurotransmitter uptake (GO:0051580)3.27902581
66negative regulation of oligodendrocyte differentiation (GO:0048715)3.26851070
67learning (GO:0007612)3.26778521
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.24989492
69innervation (GO:0060384)3.24492082
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24441937
71startle response (GO:0001964)3.23690412
72regulation of synapse structural plasticity (GO:0051823)3.23194968
73regulation of synaptic plasticity (GO:0048167)3.22111199
74positive regulation of membrane potential (GO:0045838)3.21539726
75axon extension involved in axon guidance (GO:0048846)3.20107504
76neuron projection extension involved in neuron projection guidance (GO:1902284)3.20107504
77neurotransmitter transport (GO:0006836)3.19799826
78sequestering of actin monomers (GO:0042989)3.19549555
79spinal cord association neuron differentiation (GO:0021527)3.19030340
80dendrite morphogenesis (GO:0048813)3.18545719
81forebrain neuron differentiation (GO:0021879)3.17154577
82proline transport (GO:0015824)3.15760227
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15746469
84dendrite development (GO:0016358)3.15208198
85* synapse assembly (GO:0007416)3.14190396
86head development (GO:0060322)3.12616480
87synaptic vesicle endocytosis (GO:0048488)3.11712919
88negative regulation of neurotransmitter transport (GO:0051589)3.11610583
89behavioral fear response (GO:0001662)3.11448500
90behavioral defense response (GO:0002209)3.11448500
91activation of protein kinase A activity (GO:0034199)3.10418667
92long-term memory (GO:0007616)3.06105885
93positive regulation of synapse assembly (GO:0051965)3.02003292
94membrane hyperpolarization (GO:0060081)3.01988266
95regulation of neurotransmitter levels (GO:0001505)3.00368341
96intraspecies interaction between organisms (GO:0051703)3.00030567
97social behavior (GO:0035176)3.00030567
98* synapse organization (GO:0050808)2.99724951
99protein localization to cilium (GO:0061512)2.99241585
100mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.98888968
101positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.98888968
102regulation of female receptivity (GO:0045924)2.98424028
103epithelial cilium movement (GO:0003351)2.97665167
104mating behavior (GO:0007617)2.94502843
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93020512
106regulation of neurotransmitter transport (GO:0051588)2.91830152
107membrane depolarization (GO:0051899)2.91773194
108negative regulation of sodium ion transport (GO:0010766)2.91747047
109neural tube formation (GO:0001841)2.91188790
110long term synaptic depression (GO:0060292)2.90613726
111fear response (GO:0042596)2.90562061
112ganglion development (GO:0061548)2.90266717
113regulation of neurotransmitter secretion (GO:0046928)2.90262898
114regulation of development, heterochronic (GO:0040034)2.90184213
115spinal cord development (GO:0021510)2.89570200
116cell migration in hindbrain (GO:0021535)2.89451925
117DNA damage response, detection of DNA damage (GO:0042769)2.87572874
118negative regulation of synaptic transmission (GO:0050805)2.87205970
119central nervous system projection neuron axonogenesis (GO:0021952)2.86650276
120establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86460784
121mitochondrion transport along microtubule (GO:0047497)2.86460784
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86335257
123positive regulation of synaptic transmission (GO:0050806)2.86284294
124hippocampus development (GO:0021766)2.85222509
125regulation of dendritic spine development (GO:0060998)2.85118370
126negative regulation of neurotransmitter secretion (GO:0046929)2.84460061
127synaptic transmission, dopaminergic (GO:0001963)2.83989949
128neuronal stem cell maintenance (GO:0097150)2.83838361
129cerebral cortex radially oriented cell migration (GO:0021799)2.83511059
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83325762
131G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82777033
132detection of calcium ion (GO:0005513)2.81835735
133visual learning (GO:0008542)2.81814678
134* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.81552706
135somite development (GO:0061053)2.81437112
136auditory behavior (GO:0031223)2.77819480
137negative regulation of axon guidance (GO:1902668)2.75035062
138regulation of mitochondrial fission (GO:0090140)2.73372852
139short-term memory (GO:0007614)2.70295352
140G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.66116807
141paraxial mesoderm development (GO:0048339)2.64541824
142regulation of cilium movement (GO:0003352)2.64047665
143cilium morphogenesis (GO:0060271)2.61863041
144neuron migration (GO:0001764)2.60706178
145axon extension (GO:0048675)2.53973556
146cytoskeleton-dependent intracellular transport (GO:0030705)2.50994920
147appendage development (GO:0048736)2.50745483
148limb development (GO:0060173)2.50745483
149ephrin receptor signaling pathway (GO:0048013)2.50131921
150DNA integration (GO:0015074)2.48130357
151mechanosensory behavior (GO:0007638)2.47528886
152cilium assembly (GO:0042384)2.47305300
153negative chemotaxis (GO:0050919)2.46599469
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46522524
155glycosphingolipid biosynthetic process (GO:0006688)2.45310606
156cilium organization (GO:0044782)2.44103399
157protein polyglutamylation (GO:0018095)2.42994929
158microtubule-based transport (GO:0010970)2.39259777
159response to auditory stimulus (GO:0010996)2.38977662
160sympathetic nervous system development (GO:0048485)2.38826392
161central nervous system neuron axonogenesis (GO:0021955)2.38430088
162neurofilament cytoskeleton organization (GO:0060052)2.38372160
163neuronal ion channel clustering (GO:0045161)2.37272829
164cerebral cortex cell migration (GO:0021795)2.34970537
165peptidyl-cysteine modification (GO:0018198)2.33030926
166cilium movement (GO:0003341)2.32747639
167regulation of synapse assembly (GO:0051963)2.32705107
168ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.31906447
169regulation of timing of cell differentiation (GO:0048505)2.31072118
170regulation of oligodendrocyte differentiation (GO:0048713)2.30957803
171substrate-independent telencephalic tangential migration (GO:0021826)2.30345457
172substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.30345457
173neuromuscular synaptic transmission (GO:0007274)2.30342368
174* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.28081772
175synaptic transmission, cholinergic (GO:0007271)2.27809443
176* cell-cell adhesion (GO:0098609)2.27717467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.02637624
2GBX2_23144817_ChIP-Seq_PC3_Human3.97529730
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15123864
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10156743
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06004124
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65480123
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65480123
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.64966655
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64740080
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59050937
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56006649
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.49008795
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48363790
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45856248
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40221100
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35651387
17REST_21632747_ChIP-Seq_MESCs_Mouse2.32983892
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27561453
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25868019
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17905102
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.16693888
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12829130
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08210111
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.07091968
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06451513
26AR_21572438_ChIP-Seq_LNCaP_Human2.04394641
27TAF15_26573619_Chip-Seq_HEK293_Human2.03439597
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02926685
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96045444
30DROSHA_22980978_ChIP-Seq_HELA_Human1.91822734
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90114296
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.88456039
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.85519816
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80366490
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77305870
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.75157041
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74898014
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.73413976
39P300_19829295_ChIP-Seq_ESCs_Human1.73137981
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71835023
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70465244
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69953867
43ZNF274_21170338_ChIP-Seq_K562_Hela1.69844914
44EWS_26573619_Chip-Seq_HEK293_Human1.69021859
45FUS_26573619_Chip-Seq_HEK293_Human1.68520245
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66986478
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.66040459
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.65056112
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62641349
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59167106
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58185545
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57120926
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55942667
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54419137
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53740903
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53399461
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52635990
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48867693
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.48497828
60IRF1_19129219_ChIP-ChIP_H3396_Human1.48431699
61IGF1R_20145208_ChIP-Seq_DFB_Human1.47687704
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45430844
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.44933681
64AR_25329375_ChIP-Seq_VCAP_Human1.42949972
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42803073
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42302851
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40641559
68STAT3_23295773_ChIP-Seq_U87_Human1.36767250
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31860949
70RNF2_27304074_Chip-Seq_NSC_Mouse1.31772879
71TP53_18474530_ChIP-ChIP_U2OS_Human1.31170460
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28763571
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26419957
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24925146
75VDR_22108803_ChIP-Seq_LS180_Human1.24750155
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.24596603
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23474745
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23463312
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22916295
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.22237175
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.21976441
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.21106781
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20480444
84TP53_16413492_ChIP-PET_HCT116_Human1.20023020
85TCF4_23295773_ChIP-Seq_U87_Human1.18867519
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18695017
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.18411527
88AR_19668381_ChIP-Seq_PC3_Human1.18095820
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.17452740
90RUNX2_22187159_ChIP-Seq_PCA_Human1.16733489
91AHR_22903824_ChIP-Seq_MCF-7_Human1.16480307
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.15573289
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15343505
94MYC_18940864_ChIP-ChIP_HL60_Human1.14450088
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13771905
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13610440
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.12646747
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.10953216
99CBP_20019798_ChIP-Seq_JUKART_Human1.09618417
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09618417
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09076968
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09029887
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07628057
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06913022
105SOX9_26525672_Chip-Seq_HEART_Mouse1.06147736
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05893009
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05765578
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05765578
109JUN_21703547_ChIP-Seq_K562_Human1.05518272
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05504494
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05233636
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04750928
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04733843
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04150829
115ER_23166858_ChIP-Seq_MCF-7_Human1.03956106
116FLI1_27457419_Chip-Seq_LIVER_Mouse1.03343553
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02872148
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02789204
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02340085
120EST1_17652178_ChIP-ChIP_JURKAT_Human1.01577147
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01336701
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01251027
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01132222
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00614419
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00559101
126POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99505158
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99269170
128ELK1_19687146_ChIP-ChIP_HELA_Human0.99236005
129BCAT_22108803_ChIP-Seq_LS180_Human0.99093034
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98925515
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.98688956
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97655984
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96838537
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95690721
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.93773893
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.93057894
137TP53_22573176_ChIP-Seq_HFKS_Human0.89691008
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89617485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43965930
2MP0003880_abnormal_central_pattern4.84638800
3MP0003635_abnormal_synaptic_transmissio3.80613118
4MP0009745_abnormal_behavioral_response3.36507128
5MP0002063_abnormal_learning/memory/cond3.24757334
6MP0004270_analgesia3.06998819
7MP0002064_seizures3.01164417
8MP0009046_muscle_twitch2.93936372
9MP0001968_abnormal_touch/_nociception2.88938558
10MP0001486_abnormal_startle_reflex2.75985027
11MP0002572_abnormal_emotion/affect_behav2.69340906
12MP0002272_abnormal_nervous_system2.36833188
13MP0001440_abnormal_grooming_behavior2.33491530
14MP0002102_abnormal_ear_morphology2.29095937
15MP0002734_abnormal_mechanical_nocicepti2.23264453
16MP0009780_abnormal_chondrocyte_physiolo2.21545062
17MP0000778_abnormal_nervous_system2.20869344
18MP0004133_heterotaxia2.14651361
19MP0002184_abnormal_innervation2.07740233
20MP0002067_abnormal_sensory_capabilities2.06638623
21MP0001188_hyperpigmentation2.06286483
22MP0002736_abnormal_nociception_after1.99946055
23MP0005423_abnormal_somatic_nervous1.99642393
24MP0002653_abnormal_ependyma_morphology1.96252446
25MP0002735_abnormal_chemical_nociception1.92125782
26MP0000049_abnormal_middle_ear1.82961404
27MP0001501_abnormal_sleep_pattern1.76677731
28MP0002733_abnormal_thermal_nociception1.75957296
29MP0006292_abnormal_olfactory_placode1.75294482
30MP0002638_abnormal_pupillary_reflex1.70391153
31MP0002557_abnormal_social/conspecific_i1.69581799
32MP0002837_dystrophic_cardiac_calcinosis1.69223913
33MP0005646_abnormal_pituitary_gland1.66019992
34MP0001984_abnormal_olfaction1.65745891
35MP0001970_abnormal_pain_threshold1.64028580
36MP0003122_maternal_imprinting1.60200092
37MP0003329_amyloid_beta_deposits1.60143313
38MP0000955_abnormal_spinal_cord1.59756621
39MP0005386_behavior/neurological_phenoty1.58881869
40MP0004924_abnormal_behavior1.58881869
41MP0004811_abnormal_neuron_physiology1.53626605
42MP0003890_abnormal_embryonic-extraembry1.50999871
43MP0003136_yellow_coat_color1.50365707
44MP0008877_abnormal_DNA_methylation1.48319756
45MP0001293_anophthalmia1.47987127
46MP0002233_abnormal_nose_morphology1.46544909
47MP0005187_abnormal_penis_morphology1.45793877
48MP0003787_abnormal_imprinting1.44590275
49MP0002882_abnormal_neuron_morphology1.44587683
50MP0000566_synostosis1.44319013
51MP0003879_abnormal_hair_cell1.42717145
52MP0002876_abnormal_thyroid_physiology1.36808956
53MP0003119_abnormal_digestive_system1.36404742
54MP0003937_abnormal_limbs/digits/tail_de1.35975356
55MP0004858_abnormal_nervous_system1.35137991
56MP0005551_abnormal_eye_electrophysiolog1.34875032
57MP0008569_lethality_at_weaning1.33727180
58MP0001905_abnormal_dopamine_level1.32086987
59MP0000631_abnormal_neuroendocrine_gland1.31688657
60MP0006276_abnormal_autonomic_nervous1.31661489
61MP0002066_abnormal_motor_capabilities/c1.30276795
62MP0001986_abnormal_taste_sensitivity1.29733493
63MP0002938_white_spotting1.27153426
64MP0010386_abnormal_urinary_bladder1.23151337
65MP0001502_abnormal_circadian_rhythm1.22996830
66MP0001529_abnormal_vocalization1.22840426
67MP0005171_absent_coat_pigmentation1.19537023
68MP0004885_abnormal_endolymph1.16741435
69MP0002234_abnormal_pharynx_morphology1.15746118
70MP0004142_abnormal_muscle_tone1.15235156
71MP0000026_abnormal_inner_ear1.15187068
72MP0002152_abnormal_brain_morphology1.15103772
73MP0003567_abnormal_fetal_cardiomyocyte1.14631223
74MP0002909_abnormal_adrenal_gland1.14434682
75MP0001286_abnormal_eye_development1.14205078
76MP0000647_abnormal_sebaceous_gland1.13848602
77MP0002697_abnormal_eye_size1.12553629
78MP0004742_abnormal_vestibular_system1.11814173
79MP0003755_abnormal_palate_morphology1.06964870
80MP0005391_vision/eye_phenotype1.05284693
81MP0000751_myopathy1.05160544
82MP0003633_abnormal_nervous_system1.03422995
83MP0001177_atelectasis1.02898258
84MP0001299_abnormal_eye_distance/1.01343117
85MP0002090_abnormal_vision1.01138211
86MP0006072_abnormal_retinal_apoptosis1.00476571
87MP0002822_catalepsy0.98398421
88MP0003634_abnormal_glial_cell0.98088356
89MP0005394_taste/olfaction_phenotype0.96866666
90MP0005499_abnormal_olfactory_system0.96866666
91MP0008872_abnormal_physiological_respon0.96447412
92MP0003631_nervous_system_phenotype0.95686119
93MP0005195_abnormal_posterior_eye0.91578637
94MP0000537_abnormal_urethra_morphology0.90890992
95MP0001963_abnormal_hearing_physiology0.88811051
96MP0005623_abnormal_meninges_morphology0.88755949
97MP0002752_abnormal_somatic_nervous0.87942618
98MP0002229_neurodegeneration0.86199823
99MP0002081_perinatal_lethality0.81427888
100MP0005248_abnormal_Harderian_gland0.81180400
101MP0004145_abnormal_muscle_electrophysio0.80948374
102MP0002069_abnormal_eating/drinking_beha0.80603887
103MP0003011_delayed_dark_adaptation0.80499399
104MP0004233_abnormal_muscle_weight0.80415113
105MP0003221_abnormal_cardiomyocyte_apopto0.79078770
106MP0002751_abnormal_autonomic_nervous0.76992027
107MP0003942_abnormal_urinary_system0.76173986
108MP0004484_altered_response_of0.75500000
109MP0004215_abnormal_myocardial_fiber0.74213531
110MP0003632_abnormal_nervous_system0.73579213
111MP0009250_abnormal_appendicular_skeleto0.73408759
112MP0002092_abnormal_eye_morphology0.73388883
113MP0002116_abnormal_craniofacial_bone0.73227685
114MP0003137_abnormal_impulse_conducting0.72404753
115MP0003938_abnormal_ear_development0.71756445
116MP0003935_abnormal_craniofacial_develop0.71266227
117MP0004085_abnormal_heartbeat0.70255104
118MP0001485_abnormal_pinna_reflex0.70055723
119MP0005645_abnormal_hypothalamus_physiol0.69951291
120MP0003283_abnormal_digestive_organ0.69758899
121MP0003121_genomic_imprinting0.69539457
122MP0000920_abnormal_myelination0.69486409
123MP0003861_abnormal_nervous_system0.69418069
124MP0002084_abnormal_developmental_patter0.68383883
125MP0005409_darkened_coat_color0.68379736
126MP0001943_abnormal_respiration0.67851126
127MP0003385_abnormal_body_wall0.67703922
128MP0008789_abnormal_olfactory_epithelium0.64188801
129MP0010030_abnormal_orbit_morphology0.64002008
130MP0000534_abnormal_ureter_morphology0.63784318
131MP0000013_abnormal_adipose_tissue0.62624384
132MP0005253_abnormal_eye_physiology0.62538573
133MP0000681_abnormal_thyroid_gland0.60579994
134MP0004134_abnormal_chest_morphology0.59131419

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.93669798
2Hyperventilation (HP:0002883)5.33758921
3Focal seizures (HP:0007359)5.24643689
4Atonic seizures (HP:0010819)5.12070847
5Epileptic encephalopathy (HP:0200134)5.01225339
6Absence seizures (HP:0002121)4.59845263
7Febrile seizures (HP:0002373)4.50660890
8Dialeptic seizures (HP:0011146)4.10727354
9Myokymia (HP:0002411)3.95493135
10Visual hallucinations (HP:0002367)3.86598411
11Broad-based gait (HP:0002136)3.84792888
12Progressive cerebellar ataxia (HP:0002073)3.76041253
13Generalized tonic-clonic seizures (HP:0002069)3.67977814
14Cortical dysplasia (HP:0002539)3.56960893
15Excessive salivation (HP:0003781)3.28155814
16Drooling (HP:0002307)3.28155814
17Poor eye contact (HP:0000817)3.09948674
18Epileptiform EEG discharges (HP:0011182)3.07964267
19Truncal ataxia (HP:0002078)2.99672282
20Lissencephaly (HP:0001339)2.95744348
21Progressive inability to walk (HP:0002505)2.90733551
22Abnormal social behavior (HP:0012433)2.90613320
23Impaired social interactions (HP:0000735)2.90613320
24Absent speech (HP:0001344)2.87631743
25True hermaphroditism (HP:0010459)2.86481093
26EEG with generalized epileptiform discharges (HP:0011198)2.80687508
27Aqueductal stenosis (HP:0002410)2.79549303
28Scanning speech (HP:0002168)2.79007615
29Gaze-evoked nystagmus (HP:0000640)2.77961399
30Termporal pattern (HP:0011008)2.77782369
31Insidious onset (HP:0003587)2.77782369
32Hepatoblastoma (HP:0002884)2.77122722
33Amblyopia (HP:0000646)2.73718469
34Mutism (HP:0002300)2.65604834
35Hypsarrhythmia (HP:0002521)2.61971523
36Supranuclear gaze palsy (HP:0000605)2.60628208
37Genetic anticipation (HP:0003743)2.60334015
38Pancreatic cysts (HP:0001737)2.59908448
39Cerebral inclusion bodies (HP:0100314)2.59058390
40Pancreatic fibrosis (HP:0100732)2.58901969
41Dysdiadochokinesis (HP:0002075)2.58097148
42Molar tooth sign on MRI (HP:0002419)2.50625435
43Abnormality of midbrain morphology (HP:0002418)2.50625435
44Hyperglycinemia (HP:0002154)2.50533570
45Inability to walk (HP:0002540)2.47968271
46Septo-optic dysplasia (HP:0100842)2.47050435
47Hyperthyroidism (HP:0000836)2.46972486
48Impaired vibration sensation in the lower limbs (HP:0002166)2.46163976
49Occipital encephalocele (HP:0002085)2.45581941
50Hypoplasia of the brainstem (HP:0002365)2.45372216
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.45372216
52Protruding tongue (HP:0010808)2.44187197
53Chronic hepatic failure (HP:0100626)2.42758716
54Nephronophthisis (HP:0000090)2.42043119
55Gait imbalance (HP:0002141)2.41356843
56Diplopia (HP:0000651)2.40770744
57Abnormality of binocular vision (HP:0011514)2.40770744
58Broad foot (HP:0001769)2.39685326
59Vitreoretinal degeneration (HP:0000655)2.39522042
60Optic nerve hypoplasia (HP:0000609)2.38405462
61Depression (HP:0000716)2.38131057
62Poor coordination (HP:0002370)2.36931073
63Action tremor (HP:0002345)2.36815783
64Dysmetria (HP:0001310)2.36354818
65Neurofibrillary tangles (HP:0002185)2.36134354
66Postaxial hand polydactyly (HP:0001162)2.35184806
67Thickened helices (HP:0000391)2.32930639
68Pachygyria (HP:0001302)2.30205642
69Pheochromocytoma (HP:0002666)2.29804547
70Hypoventilation (HP:0002791)2.28987632
71Limb dystonia (HP:0002451)2.28095433
72Abnormality of salivation (HP:0100755)2.27564416
73Hemiparesis (HP:0001269)2.22221561
74Urinary bladder sphincter dysfunction (HP:0002839)2.21915473
75Abnormality of the corticospinal tract (HP:0002492)2.19554136
76Renal hypoplasia (HP:0000089)2.18692769
77Blue irides (HP:0000635)2.18420657
78Buphthalmos (HP:0000557)2.18058252
79Abnormal eating behavior (HP:0100738)2.16552781
80Intestinal atresia (HP:0011100)2.15593878
81Anxiety (HP:0000739)2.14639018
82Anophthalmia (HP:0000528)2.14019613
83Abnormality of the musculature of the pelvis (HP:0001469)2.13717287
84Abnormality of the hip-girdle musculature (HP:0001445)2.13717287
85Stereotypic behavior (HP:0000733)2.12742722
86Amyotrophic lateral sclerosis (HP:0007354)2.12318170
87Type II lissencephaly (HP:0007260)2.11223295
88Agitation (HP:0000713)2.09926714
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07668601
90Postural instability (HP:0002172)2.07599410
91Decreased testicular size (HP:0008734)2.07276083
92Shoulder girdle muscle weakness (HP:0003547)2.06217849
93Fetal akinesia sequence (HP:0001989)2.03073937
94Failure to thrive in infancy (HP:0001531)2.02061126
95Impaired smooth pursuit (HP:0007772)2.01707154
96Micropenis (HP:0000054)2.01507255
97Split foot (HP:0001839)1.99230993
98Narrow forehead (HP:0000341)1.98902573
99Congenital primary aphakia (HP:0007707)1.97839764
100Lower limb muscle weakness (HP:0007340)1.95470191
101Urinary urgency (HP:0000012)1.95455737
102Degeneration of the lateral corticospinal tracts (HP:0002314)1.95435773
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95435773
104Rib fusion (HP:0000902)1.94952409
105Abnormality of the renal medulla (HP:0100957)1.94788355
106Colon cancer (HP:0003003)1.94534221
107Anencephaly (HP:0002323)1.94367510
108Cutaneous finger syndactyly (HP:0010554)1.93848279
109Postaxial foot polydactyly (HP:0001830)1.93247247
110Generalized myoclonic seizures (HP:0002123)1.92606421
111Intention tremor (HP:0002080)1.91988674
112Medial flaring of the eyebrow (HP:0010747)1.91732896
113Sclerocornea (HP:0000647)1.90515803
114Hemivertebrae (HP:0002937)1.90497005
115Polyphagia (HP:0002591)1.89327534
116Hypoplastic pelvis (HP:0008839)1.88450089
117Clumsiness (HP:0002312)1.87672287
118Oligodactyly (hands) (HP:0001180)1.87611940
119Ankle clonus (HP:0011448)1.87141123
120Gait ataxia (HP:0002066)1.86482065
121Inappropriate behavior (HP:0000719)1.85486313
122Akinesia (HP:0002304)1.85279477
123Polymicrogyria (HP:0002126)1.84196852
124Abnormality of ocular smooth pursuit (HP:0000617)1.83611543
125Bradykinesia (HP:0002067)1.83487719
126Annular pancreas (HP:0001734)1.82655772
127Preaxial hand polydactyly (HP:0001177)1.82296294
128Abnormality of the labia minora (HP:0012880)1.82133004
129Spastic gait (HP:0002064)1.82044830
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.80826124
131Thyroid-stimulating hormone excess (HP:0002925)1.80595058
132Abnormality of macular pigmentation (HP:0008002)1.80355928
133Neuroendocrine neoplasm (HP:0100634)1.80234295
134Retinal dysplasia (HP:0007973)1.80223229
135Labial hypoplasia (HP:0000066)1.79951711
136Spastic tetraplegia (HP:0002510)1.79385330
137Lower limb asymmetry (HP:0100559)1.78620395
138Bifid tongue (HP:0010297)1.78448550
139High anterior hairline (HP:0009890)1.77597872
140Deep palmar crease (HP:0006191)1.77166170
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.76988145
142Neoplasm of the peripheral nervous system (HP:0100007)1.76827121
143Narrow nasal bridge (HP:0000446)1.76666582
144Specific learning disability (HP:0001328)1.76294808
145Generalized hypotonia (HP:0001290)1.76100366
146Open mouth (HP:0000194)1.76052714
147Meningocele (HP:0002435)1.75567336
148Resting tremor (HP:0002322)1.74278100
149Aplasia/Hypoplasia of the lens (HP:0008063)1.73856206
150Genital tract atresia (HP:0001827)1.73802182
151Vaginal atresia (HP:0000148)1.73725342
152Nephrogenic diabetes insipidus (HP:0009806)1.73720319
153Dandy-Walker malformation (HP:0001305)1.73470136
154Scrotal hypoplasia (HP:0000046)1.73303799
155Cutaneous syndactyly (HP:0012725)1.73087467
156Autism (HP:0000717)1.72649739
157Exotropia (HP:0000577)1.72147942
158Cystic liver disease (HP:0006706)1.72125534
159Short foot (HP:0001773)1.71611228
160Lower limb amyotrophy (HP:0007210)1.71275053
161Abnormality of the lower motor neuron (HP:0002366)1.71234501
162Status epilepticus (HP:0002133)1.71204183
163Anosmia (HP:0000458)1.70851032
164Tubulointerstitial nephritis (HP:0001970)1.69776558
165Morphological abnormality of the middle ear (HP:0008609)1.69109652
166Oligodactyly (HP:0012165)1.68686712
167Chorioretinal coloboma (HP:0000567)1.66413878
168Renal dysplasia (HP:0000110)1.66378034
169Absent septum pellucidum (HP:0001331)1.65151132
170Abnormality of glycine metabolism (HP:0010895)1.65123274
171Abnormality of serine family amino acid metabolism (HP:0010894)1.65123274
172Myelomeningocele (HP:0002475)1.64605349
173Abnormality of the intervertebral disk (HP:0005108)1.64151745
174Patellar aplasia (HP:0006443)1.63658675
175Short tibia (HP:0005736)1.63157447
176Cerebellar dysplasia (HP:0007033)1.63129746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.12823671
2NTRK33.96128567
3CASK3.93023859
4MARK13.24535747
5TRIM283.18856966
6MAP3K42.91013228
7PLK22.87367035
8MAP3K92.74066950
9MAP2K72.54861549
10DYRK22.45139672
11MINK12.40821378
12EPHA32.32591766
13NTRK22.24620521
14SRPK12.16609607
15MAP4K22.16452155
16TNIK2.01712371
17KSR12.00004632
18PAK61.97821812
19ERBB31.97216031
20CSNK1G31.94785902
21CSNK1A1L1.84338695
22AKT31.83189938
23CSNK1G11.73617407
24CCNB11.73559783
25PINK11.71995065
26DYRK31.70645021
27MAP3K121.70193145
28SIK21.58455738
29KSR21.58203217
30DAPK21.50577252
31MAPK131.50331538
32EPHB21.48993055
33PNCK1.44568514
34MAP2K41.43974309
35CDK51.43352355
36NTRK11.39439065
37BCKDK1.34648999
38PRKCG1.31717348
39DAPK11.31312882
40MKNK11.29070627
41DYRK1B1.29003790
42RIPK41.24274834
43PAK31.21825632
44FGFR21.21783635
45GRK51.17646685
46CAMK2A1.15826234
47RPS6KA41.15510715
48STK38L1.14230753
49LATS21.13376237
50CAMKK21.11170621
51PHKG21.10549358
52PHKG11.10549358
53CAMKK11.08754037
54BMPR21.07767908
55ARAF1.04090900
56FES1.00302348
57MKNK20.99603472
58CDK190.98095897
59CDK140.96573471
60CAMK2B0.93087636
61MAP3K20.93028528
62UHMK10.92534996
63FER0.92369917
64CDK180.92186486
65PRKCE0.91248376
66LIMK10.91202492
67SGK4940.90621435
68SGK2230.90621435
69PTK2B0.90499678
70BCR0.88735288
71SGK20.87486780
72PRPF4B0.87173663
73CDK150.86155379
74NEK10.84017709
75OXSR10.80032209
76DDR20.78562060
77RET0.77734748
78WNK30.77283331
79SIK30.75555520
80ADRBK20.75068135
81TSSK60.71352261
82CDK11A0.70158752
83ROCK20.69767529
84RAF10.69017532
85CSNK1G20.68328569
86PKN10.66840413
87SGK10.65158996
88NUAK10.64679208
89FGR0.64269442
90TIE10.59810164
91MAP2K10.59175151
92GRK10.58897823
93PRKCZ0.58733192
94TYRO30.58092431
95MAP3K60.57892316
96ROCK10.56802193
97DYRK1A0.56013033
98SGK30.55901661
99FRK0.55555014
100PLK30.55093738
101BRD40.52851610
102LMTK20.52633941
103CAMK2G0.52533661
104STK110.51738357
105MUSK0.50950205
106FYN0.50775626
107CAMK2D0.49515636
108BRAF0.49080592
109PRKD30.48781976
110PIK3CA0.48121489
111LATS10.48058950
112PRKCH0.47504784
113ERBB20.47107199
114VRK10.46691612
115PLK10.46300818
116ZAK0.46129236
117CSNK1A10.45710402
118CDC42BPA0.45590646
119RPS6KA30.45546642
120CSNK1D0.44425014
121WNK40.44330192
122MAPK150.43788668
123ADRBK10.43326228
124MARK20.40563143
125MAP3K50.40457726
126PRKAA10.39866554
127DMPK0.39495937
128MAP3K130.39463697
129CSNK1E0.38313096
130MAPK100.38279185
131PRKCB0.38211928
132PRKG10.37399240
133STK160.37316938
134BMPR1B0.35372035
135FGFR10.34813451
136NEK60.33996355
137PRKACA0.33274828
138CAMK10.33249361
139MAPK90.32939010
140EPHB10.32850348
141MYLK0.32729442
142CAMK40.32573438
143INSRR0.32507288
144PRKACB0.31957978
145RPS6KA50.31717154
146PLK40.28717196
147TESK10.27302922
148PRKDC0.26654672
149ATM0.24583329
150CDK30.23765611

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88649769
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02962793
3GABAergic synapse_Homo sapiens_hsa047272.82087841
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73567112
5Steroid biosynthesis_Homo sapiens_hsa001002.63011802
6Long-term potentiation_Homo sapiens_hsa047202.62880239
7Circadian entrainment_Homo sapiens_hsa047132.59513703
8Morphine addiction_Homo sapiens_hsa050322.49165384
9Glutamatergic synapse_Homo sapiens_hsa047242.45699854
10Amphetamine addiction_Homo sapiens_hsa050312.34942775
11Protein export_Homo sapiens_hsa030602.33311324
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18503517
13Olfactory transduction_Homo sapiens_hsa047402.18272290
14Dopaminergic synapse_Homo sapiens_hsa047282.17862300
15Collecting duct acid secretion_Homo sapiens_hsa049662.09635976
16Salivary secretion_Homo sapiens_hsa049702.02078015
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99768996
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92477298
19Long-term depression_Homo sapiens_hsa047301.86826569
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86655282
21Taste transduction_Homo sapiens_hsa047421.83783807
22Renin secretion_Homo sapiens_hsa049241.80616354
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79859843
24Cholinergic synapse_Homo sapiens_hsa047251.79091701
25Serotonergic synapse_Homo sapiens_hsa047261.76865107
26Insulin secretion_Homo sapiens_hsa049111.66022790
27Oxytocin signaling pathway_Homo sapiens_hsa049211.63970436
28Basal cell carcinoma_Homo sapiens_hsa052171.63495323
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63036688
30Basal transcription factors_Homo sapiens_hsa030221.62487014
31Parkinsons disease_Homo sapiens_hsa050121.59920696
32Phototransduction_Homo sapiens_hsa047441.57932775
33Cocaine addiction_Homo sapiens_hsa050301.57863645
34Gastric acid secretion_Homo sapiens_hsa049711.57549301
35Propanoate metabolism_Homo sapiens_hsa006401.57428571
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53775285
37Axon guidance_Homo sapiens_hsa043601.53001437
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48235582
39Hippo signaling pathway_Homo sapiens_hsa043901.47000918
40Vibrio cholerae infection_Homo sapiens_hsa051101.46542372
41Calcium signaling pathway_Homo sapiens_hsa040201.44060077
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43982744
43Gap junction_Homo sapiens_hsa045401.41461148
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41057463
45Hedgehog signaling pathway_Homo sapiens_hsa043401.39284379
46GnRH signaling pathway_Homo sapiens_hsa049121.36245504
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33465784
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26402724
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24826984
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21304501
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18762711
52Glioma_Homo sapiens_hsa052141.16529016
53Huntingtons disease_Homo sapiens_hsa050161.15874815
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13878032
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12876009
56cAMP signaling pathway_Homo sapiens_hsa040241.10870189
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08651352
58Melanogenesis_Homo sapiens_hsa049161.07028211
59Estrogen signaling pathway_Homo sapiens_hsa049151.06558126
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.99762514
61RNA polymerase_Homo sapiens_hsa030200.96692924
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95908442
63ErbB signaling pathway_Homo sapiens_hsa040120.95795734
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95615574
65RNA degradation_Homo sapiens_hsa030180.94743778
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94050862
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93265699
68Spliceosome_Homo sapiens_hsa030400.92788566
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89846415
70Fanconi anemia pathway_Homo sapiens_hsa034600.89603830
71Type II diabetes mellitus_Homo sapiens_hsa049300.88732615
72Fatty acid elongation_Homo sapiens_hsa000620.88086514
73Non-homologous end-joining_Homo sapiens_hsa034500.87835583
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87752161
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87549453
76RNA transport_Homo sapiens_hsa030130.84741067
77Cardiac muscle contraction_Homo sapiens_hsa042600.84221868
78Peroxisome_Homo sapiens_hsa041460.83584364
79Butanoate metabolism_Homo sapiens_hsa006500.82169128
80Dilated cardiomyopathy_Homo sapiens_hsa054140.80557317
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.80023082
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79975522
83Biosynthesis of amino acids_Homo sapiens_hsa012300.77968512
84Dorso-ventral axis formation_Homo sapiens_hsa043200.77732738
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76742487
86Regulation of autophagy_Homo sapiens_hsa041400.75978014
87Oocyte meiosis_Homo sapiens_hsa041140.75533025
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75162114
89mRNA surveillance pathway_Homo sapiens_hsa030150.74340269
90Tight junction_Homo sapiens_hsa045300.74163194
91Fatty acid metabolism_Homo sapiens_hsa012120.73877124
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73365306
93Arginine and proline metabolism_Homo sapiens_hsa003300.69799669
94Base excision repair_Homo sapiens_hsa034100.69337853
95Selenocompound metabolism_Homo sapiens_hsa004500.69067435
96Thyroid hormone synthesis_Homo sapiens_hsa049180.68824269
97Choline metabolism in cancer_Homo sapiens_hsa052310.68618041
98MAPK signaling pathway_Homo sapiens_hsa040100.68328333
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.66800564
100Ether lipid metabolism_Homo sapiens_hsa005650.66760312
101Nitrogen metabolism_Homo sapiens_hsa009100.66299989
102Alzheimers disease_Homo sapiens_hsa050100.65436651
103Ras signaling pathway_Homo sapiens_hsa040140.64001064
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62310098
105Pancreatic secretion_Homo sapiens_hsa049720.62049349
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62047759
107Rap1 signaling pathway_Homo sapiens_hsa040150.59498314
108African trypanosomiasis_Homo sapiens_hsa051430.58797020
109Type I diabetes mellitus_Homo sapiens_hsa049400.57465810
110Notch signaling pathway_Homo sapiens_hsa043300.57161191
111Oxidative phosphorylation_Homo sapiens_hsa001900.55986638
112Alcoholism_Homo sapiens_hsa050340.55963241
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55906944
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54460100
115beta-Alanine metabolism_Homo sapiens_hsa004100.54343484
116VEGF signaling pathway_Homo sapiens_hsa043700.53771602
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53339397
118Wnt signaling pathway_Homo sapiens_hsa043100.52452472
119Renal cell carcinoma_Homo sapiens_hsa052110.52444984
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51860284
121Endometrial cancer_Homo sapiens_hsa052130.51622256
122AMPK signaling pathway_Homo sapiens_hsa041520.51411019
123Glucagon signaling pathway_Homo sapiens_hsa049220.51001723
124Non-small cell lung cancer_Homo sapiens_hsa052230.50648426
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.50605563
126Metabolic pathways_Homo sapiens_hsa011000.49214183
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49075186
128Linoleic acid metabolism_Homo sapiens_hsa005910.48332973
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48241936
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46391777
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46247118
132Ovarian steroidogenesis_Homo sapiens_hsa049130.46008765
133Carbon metabolism_Homo sapiens_hsa012000.45847500
134Rheumatoid arthritis_Homo sapiens_hsa053230.45495728
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.44983479
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44648713
137Vitamin B6 metabolism_Homo sapiens_hsa007500.44360597
138Pyruvate metabolism_Homo sapiens_hsa006200.43706655
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43238663
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.42727802
141Melanoma_Homo sapiens_hsa052180.42171074
142mTOR signaling pathway_Homo sapiens_hsa041500.40034985
143Phagosome_Homo sapiens_hsa041450.39326701
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39252185
145Adherens junction_Homo sapiens_hsa045200.37641143
146Colorectal cancer_Homo sapiens_hsa052100.37040830
147TGF-beta signaling pathway_Homo sapiens_hsa043500.35720490
148Insulin signaling pathway_Homo sapiens_hsa049100.35533369
149Prion diseases_Homo sapiens_hsa050200.35188235
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34791628
151Circadian rhythm_Homo sapiens_hsa047100.31042896
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30994798
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30403151
154Inositol phosphate metabolism_Homo sapiens_hsa005620.29511310
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25475500

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