PCDHB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.74409973
2pyrimidine nucleobase catabolic process (GO:0006208)5.52970742
3protein localization to synapse (GO:0035418)5.28497009
4synaptic vesicle exocytosis (GO:0016079)5.18754460
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.16138204
6regulation of synaptic vesicle exocytosis (GO:2000300)4.93446457
7vocalization behavior (GO:0071625)4.90611463
8limb bud formation (GO:0060174)4.77690205
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75542924
10locomotory exploration behavior (GO:0035641)4.59729348
11dendritic spine morphogenesis (GO:0060997)4.54835032
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.53873698
13neuron cell-cell adhesion (GO:0007158)4.49541650
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.46064663
15positive regulation of synapse maturation (GO:0090129)4.37560010
16regulation of glutamate receptor signaling pathway (GO:1900449)4.32078837
17synaptic vesicle maturation (GO:0016188)4.29931550
18neurotransmitter-gated ion channel clustering (GO:0072578)4.29020644
19nucleobase catabolic process (GO:0046113)4.24574746
20sympathetic nervous system development (GO:0048485)4.20826623
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.19263590
22cellular potassium ion homeostasis (GO:0030007)4.15235721
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.14992907
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.13972977
25neuron-neuron synaptic transmission (GO:0007270)4.11475290
26glutamate secretion (GO:0014047)4.10987902
27regulation of synaptic vesicle transport (GO:1902803)4.10860262
28neurotransmitter secretion (GO:0007269)4.09447724
29glutamate receptor signaling pathway (GO:0007215)4.05679635
30synaptic transmission, glutamatergic (GO:0035249)3.99942339
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95638737
32presynaptic membrane assembly (GO:0097105)3.90193187
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.89912650
34sodium ion export (GO:0071436)3.87868051
35negative regulation of cytosolic calcium ion concentration (GO:0051481)3.87558313
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85725333
37neuron recognition (GO:0008038)3.85179400
38innervation (GO:0060384)3.77356770
39transmission of nerve impulse (GO:0019226)3.71617021
40exploration behavior (GO:0035640)3.70128905
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.68014104
42glial cell proliferation (GO:0014009)3.66595768
43* synapse assembly (GO:0007416)3.65454696
44layer formation in cerebral cortex (GO:0021819)3.63145334
45prepulse inhibition (GO:0060134)3.60390450
46proline transport (GO:0015824)3.60375311
47spinal cord development (GO:0021510)3.54152843
48regulation of synapse structural plasticity (GO:0051823)3.52544583
49axonal fasciculation (GO:0007413)3.51813368
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50190376
51presynaptic membrane organization (GO:0097090)3.47687149
52mating behavior (GO:0007617)3.45917847
53positive regulation of membrane potential (GO:0045838)3.43531225
54regulation of neurotransmitter secretion (GO:0046928)3.42594899
55postsynaptic membrane organization (GO:0001941)3.41912208
56regulation of synapse maturation (GO:0090128)3.41651350
57regulation of neuronal synaptic plasticity (GO:0048168)3.40987867
58neurotransmitter transport (GO:0006836)3.40810102
59striatum development (GO:0021756)3.39399593
60dendrite morphogenesis (GO:0048813)3.39232205
61long-term synaptic potentiation (GO:0060291)3.35264031
62response to histamine (GO:0034776)3.32416591
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32269378
64long-term memory (GO:0007616)3.28939635
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28935472
66cell communication by electrical coupling (GO:0010644)3.28507178
67establishment of mitochondrion localization (GO:0051654)3.27683364
68neuronal action potential propagation (GO:0019227)3.27496440
69regulation of dendritic spine morphogenesis (GO:0061001)3.27456879
70long term synaptic depression (GO:0060292)3.27127139
71membrane hyperpolarization (GO:0060081)3.24381755
72ganglion development (GO:0061548)3.24249137
73regulation of postsynaptic membrane potential (GO:0060078)3.23981797
74retinal ganglion cell axon guidance (GO:0031290)3.23359661
75regulation of neurotransmitter transport (GO:0051588)3.22331312
76synaptic transmission, dopaminergic (GO:0001963)3.20840404
77neuron projection extension involved in neuron projection guidance (GO:1902284)3.20455527
78axon extension involved in axon guidance (GO:0048846)3.20455527
79potassium ion homeostasis (GO:0055075)3.19839603
80retinal rod cell development (GO:0046548)3.16986865
81membrane depolarization during action potential (GO:0086010)3.16813347
82cerebellar granule cell differentiation (GO:0021707)3.16422526
83neural tube formation (GO:0001841)3.14513913
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.12988664
85olfactory bulb development (GO:0021772)3.10920295
86central nervous system projection neuron axonogenesis (GO:0021952)3.10851381
87behavioral response to ethanol (GO:0048149)3.10781153
88dendritic spine organization (GO:0097061)3.07965394
89* synapse organization (GO:0050808)3.04582409
90cardiac right ventricle morphogenesis (GO:0003215)3.03815610
91behavioral response to cocaine (GO:0048148)3.03371109
92positive regulation of neurotransmitter transport (GO:0051590)3.03001157
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02164936
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.00670839
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99286864
96regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.98992542
97regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.98992542
98regulation of neurotransmitter levels (GO:0001505)2.98166722
99synaptic vesicle endocytosis (GO:0048488)2.96945203
100regulation of synaptic plasticity (GO:0048167)2.95673503
101learning (GO:0007612)2.95655972
102gamma-aminobutyric acid transport (GO:0015812)2.95583807
103positive regulation of synapse assembly (GO:0051965)2.95416989
104somite development (GO:0061053)2.94821505
105atrial cardiac muscle cell action potential (GO:0086014)2.93477567
106* synaptic transmission (GO:0007268)2.92755286
107cardiac ventricle formation (GO:0003211)2.92533212
108* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.91990451
109membrane depolarization (GO:0051899)2.89850794
110paraxial mesoderm development (GO:0048339)2.89765155
111positive regulation of dendritic spine development (GO:0060999)2.89709760
112activation of protein kinase A activity (GO:0034199)2.87672122
113behavioral fear response (GO:0001662)2.86075252
114behavioral defense response (GO:0002209)2.86075252
115regulation of vesicle fusion (GO:0031338)2.85777153
116axon extension (GO:0048675)2.85646959
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83656794
118positive regulation of neurotransmitter secretion (GO:0001956)2.83635404
119regulation of dendritic spine development (GO:0060998)2.82202626
120cell migration in hindbrain (GO:0021535)2.81863317
121* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.80933780
122ephrin receptor signaling pathway (GO:0048013)2.79425762
123neuronal ion channel clustering (GO:0045161)2.75230416
124cardiac chamber formation (GO:0003207)2.74676996
125ectodermal placode formation (GO:0060788)2.73466697
126central nervous system neuron axonogenesis (GO:0021955)2.72216297
127hippocampus development (GO:0021766)2.72127445
128adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70019664
129regulation of respiratory system process (GO:0044065)2.69622645
130intraciliary transport (GO:0042073)2.56977980
131regulation of synapse assembly (GO:0051963)2.55836968
132DNA damage response, detection of DNA damage (GO:0042769)2.55508439
133positive regulation of mitochondrial fission (GO:0090141)2.54789767
134negative chemotaxis (GO:0050919)2.53556924
135forebrain neuron differentiation (GO:0021879)2.53154460
136regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.52552860
137dendrite development (GO:0016358)2.51684489
138neuron migration (GO:0001764)2.51509420
139auditory behavior (GO:0031223)2.49649952
140neuron projection extension (GO:1990138)2.48557236
141lens morphogenesis in camera-type eye (GO:0002089)2.48544645
142nonmotile primary cilium assembly (GO:0035058)2.46287119
143regulation of growth hormone secretion (GO:0060123)2.45176889
144establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.41712990
145mitochondrion transport along microtubule (GO:0047497)2.41712990
146head development (GO:0060322)2.38933966
147negative regulation of oligodendrocyte differentiation (GO:0048715)2.38485558
148regulation of chemokine-mediated signaling pathway (GO:0070099)2.37921634
149prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.37122741
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34035541
151peristalsis (GO:0030432)2.33812814
152axonogenesis (GO:0007409)2.33519695
153regulation of axon guidance (GO:1902667)2.31372391
154gastrulation with mouth forming second (GO:0001702)2.27918980
155short-term memory (GO:0007614)2.24949624
156G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.24198120
157asymmetric protein localization (GO:0008105)2.23716273
158glycosphingolipid biosynthetic process (GO:0006688)2.22428461
159* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.21750525
160* cell-cell adhesion (GO:0098609)2.21370364
161negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.20913497
162camera-type eye morphogenesis (GO:0048593)2.20787941
163cerebral cortex radially oriented cell migration (GO:0021799)2.19715011
164photoreceptor cell differentiation (GO:0046530)2.17391129
165eye photoreceptor cell differentiation (GO:0001754)2.17391129
166apical protein localization (GO:0045176)2.16791181
167substrate-independent telencephalic tangential migration (GO:0021826)2.15542267
168substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.15542267
169cranial nerve morphogenesis (GO:0021602)2.15426932
170regulation of axon extension involved in axon guidance (GO:0048841)2.13019614
171kidney morphogenesis (GO:0060993)2.12759043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.52110888
2GBX2_23144817_ChIP-Seq_PC3_Human4.19869211
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18269559
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06195075
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95684599
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95626944
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91396325
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.71706483
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66179426
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55404797
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55404797
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54853788
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49019758
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45158791
15REST_21632747_ChIP-Seq_MESCs_Mouse2.44249470
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37506987
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35457172
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.34809279
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34295523
20DROSHA_22980978_ChIP-Seq_HELA_Human2.33788770
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.32870166
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.25687060
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21678666
24AR_21572438_ChIP-Seq_LNCaP_Human2.20968065
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.09995859
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03997289
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89641874
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89539977
29TAF15_26573619_Chip-Seq_HEK293_Human1.85903553
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84011444
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83755439
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.83253111
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80956719
34SMAD4_21799915_ChIP-Seq_A2780_Human1.77493138
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74222028
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66820513
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62887213
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62342245
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59586989
40FUS_26573619_Chip-Seq_HEK293_Human1.58440369
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57871094
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.57472945
43P300_19829295_ChIP-Seq_ESCs_Human1.56771911
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55625484
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.49531455
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49180570
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47360755
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46434575
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.42302664
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.42237910
51IGF1R_20145208_ChIP-Seq_DFB_Human1.40566166
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39568543
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39015014
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38811171
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.36979063
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34031833
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33325431
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.32068081
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.32018111
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.31910372
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30694922
62AR_25329375_ChIP-Seq_VCAP_Human1.29671436
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28361848
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.28305296
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28112549
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.27120002
67ZNF274_21170338_ChIP-Seq_K562_Hela1.26627656
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25593179
69STAT3_23295773_ChIP-Seq_U87_Human1.24905598
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.23905184
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22384758
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.22160604
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22138151
74ER_23166858_ChIP-Seq_MCF-7_Human1.20601669
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20537233
76VDR_22108803_ChIP-Seq_LS180_Human1.20362833
77RNF2_27304074_Chip-Seq_NSC_Mouse1.19759814
78AR_19668381_ChIP-Seq_PC3_Human1.19478685
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18099185
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17996489
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17332159
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17292913
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.16812139
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16281868
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16221523
86EWS_26573619_Chip-Seq_HEK293_Human1.15709872
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13005270
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10950713
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10164834
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09772169
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09772169
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09548124
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09413517
94TCF4_23295773_ChIP-Seq_U87_Human1.09196523
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08515877
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07734217
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07725766
98SOX9_26525672_Chip-Seq_HEART_Mouse1.07261428
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07025650
100BCAT_22108803_ChIP-Seq_LS180_Human1.05482708
101RUNX2_22187159_ChIP-Seq_PCA_Human1.05234624
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03949843
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.03787386
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03240145
105AHR_22903824_ChIP-Seq_MCF-7_Human1.03091758
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02281295
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01129221
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00498539
109JUN_21703547_ChIP-Seq_K562_Human1.00422069
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.99891521
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98348392
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98303989
113POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.97950194
114IRF1_19129219_ChIP-ChIP_H3396_Human0.97816174
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.96841398
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.96531445
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96469546
118CBP_20019798_ChIP-Seq_JUKART_Human0.96219410
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96219410
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96195319
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95883855
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95165557
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94219407
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94106057
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.94000791
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93985100
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93808831
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93650734
129TP53_16413492_ChIP-PET_HCT116_Human0.93453776
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92649407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.95368384
2MP0004859_abnormal_synaptic_plasticity4.77113465
3MP0003635_abnormal_synaptic_transmissio3.63448862
4MP0009745_abnormal_behavioral_response3.10783634
5MP0002064_seizures2.91310206
6MP0005551_abnormal_eye_electrophysiolog2.86076863
7MP0002063_abnormal_learning/memory/cond2.85495171
8MP0004270_analgesia2.83163813
9MP0001968_abnormal_touch/_nociception2.70878468
10MP0002638_abnormal_pupillary_reflex2.69361180
11MP0009046_muscle_twitch2.67365335
12MP0005423_abnormal_somatic_nervous2.47913965
13MP0002272_abnormal_nervous_system2.38811995
14MP0002572_abnormal_emotion/affect_behav2.35163483
15MP0001984_abnormal_olfaction2.32404217
16MP0002734_abnormal_mechanical_nocicepti2.28586008
17MP0001486_abnormal_startle_reflex2.26094728
18MP0001440_abnormal_grooming_behavior2.14948348
19MP0002751_abnormal_autonomic_nervous2.11201236
20MP0000537_abnormal_urethra_morphology2.08876600
21MP0005394_taste/olfaction_phenotype2.08456175
22MP0005499_abnormal_olfactory_system2.08456175
23MP0003787_abnormal_imprinting2.07913863
24MP0002184_abnormal_innervation2.06253053
25MP0002067_abnormal_sensory_capabilities1.99635358
26MP0000778_abnormal_nervous_system1.96827587
27MP0002822_catalepsy1.94089084
28MP0003122_maternal_imprinting1.87118085
29MP0010386_abnormal_urinary_bladder1.86433231
30MP0003329_amyloid_beta_deposits1.81997734
31MP0006072_abnormal_retinal_apoptosis1.80864184
32MP0001501_abnormal_sleep_pattern1.73394016
33MP0006276_abnormal_autonomic_nervous1.68741229
34MP0002090_abnormal_vision1.68733182
35MP0002736_abnormal_nociception_after1.67936369
36MP0002733_abnormal_thermal_nociception1.66563366
37MP0004858_abnormal_nervous_system1.65127681
38MP0005386_behavior/neurological_phenoty1.64807317
39MP0004924_abnormal_behavior1.64807317
40MP0008569_lethality_at_weaning1.64206566
41MP0001970_abnormal_pain_threshold1.61553582
42MP0002557_abnormal_social/conspecific_i1.59883765
43MP0000049_abnormal_middle_ear1.59194594
44MP0009780_abnormal_chondrocyte_physiolo1.58867783
45MP0000955_abnormal_spinal_cord1.58181750
46MP0002735_abnormal_chemical_nociception1.57238463
47MP0003890_abnormal_embryonic-extraembry1.54944266
48MP0008789_abnormal_olfactory_epithelium1.54753380
49MP0001905_abnormal_dopamine_level1.51086423
50MP0002882_abnormal_neuron_morphology1.48578971
51MP0001502_abnormal_circadian_rhythm1.47967250
52MP0005187_abnormal_penis_morphology1.46008462
53MP0002234_abnormal_pharynx_morphology1.44801609
54MP0004811_abnormal_neuron_physiology1.42746205
55MP0003861_abnormal_nervous_system1.42132711
56MP0005253_abnormal_eye_physiology1.38026411
57MP0002233_abnormal_nose_morphology1.36578884
58MP0002909_abnormal_adrenal_gland1.34847663
59MP0004885_abnormal_endolymph1.31094360
60MP0002697_abnormal_eye_size1.31077536
61MP0003937_abnormal_limbs/digits/tail_de1.30667388
62MP0010030_abnormal_orbit_morphology1.26807675
63MP0003879_abnormal_hair_cell1.26540441
64MP0002066_abnormal_motor_capabilities/c1.24895120
65MP0000751_myopathy1.24772829
66MP0003011_delayed_dark_adaptation1.23708378
67MP0002837_dystrophic_cardiac_calcinosis1.22867853
68MP0004145_abnormal_muscle_electrophysio1.22455165
69MP0004133_heterotaxia1.22358766
70MP0003385_abnormal_body_wall1.22267978
71MP0003315_abnormal_perineum_morphology1.20469010
72MP0004742_abnormal_vestibular_system1.19786427
73MP0003633_abnormal_nervous_system1.19688292
74MP0002229_neurodegeneration1.18631078
75MP0003755_abnormal_palate_morphology1.16566962
76MP0001286_abnormal_eye_development1.15441418
77MP0006292_abnormal_olfactory_placode1.15367767
78MP0001529_abnormal_vocalization1.14974430
79MP0005248_abnormal_Harderian_gland1.14747291
80MP0003119_abnormal_digestive_system1.14092263
81MP0000013_abnormal_adipose_tissue1.12939284
82MP0000647_abnormal_sebaceous_gland1.12600639
83MP0003938_abnormal_ear_development1.12103063
84MP0002752_abnormal_somatic_nervous1.11181073
85MP0002092_abnormal_eye_morphology1.10093638
86MP0001293_anophthalmia1.09838453
87MP0003115_abnormal_respiratory_system1.09566171
88MP0004233_abnormal_muscle_weight1.09493095
89MP0003121_genomic_imprinting1.07041644
90MP0005195_abnormal_posterior_eye1.06642784
91MP0004142_abnormal_muscle_tone1.06575851
92MP0004215_abnormal_myocardial_fiber1.06472304
93MP0003942_abnormal_urinary_system1.06126191
94MP0000631_abnormal_neuroendocrine_gland1.05844117
95MP0002152_abnormal_brain_morphology1.03945028
96MP0004147_increased_porphyrin_level1.03420051
97MP0000534_abnormal_ureter_morphology1.02729241
98MP0000516_abnormal_urinary_system1.02607229
99MP0005367_renal/urinary_system_phenotyp1.02607229
100MP0001177_atelectasis1.02555438
101MP0003567_abnormal_fetal_cardiomyocyte1.02346644
102MP0003935_abnormal_craniofacial_develop1.01594668
103MP0003631_nervous_system_phenotype1.01228767
104MP0005646_abnormal_pituitary_gland1.00428025
105MP0009384_cardiac_valve_regurgitation1.00229885
106MP0000462_abnormal_digestive_system1.00035257
107MP0002102_abnormal_ear_morphology0.99137502
108MP0005391_vision/eye_phenotype0.98826781
109MP0010234_abnormal_vibrissa_follicle0.98619097
110MP0003221_abnormal_cardiomyocyte_apopto0.97475317
111MP0001963_abnormal_hearing_physiology0.96905353
112MP0001188_hyperpigmentation0.96768606
113MP0000538_abnormal_urinary_bladder0.95639909
114MP0008995_early_reproductive_senescence0.94746099
115MP0002249_abnormal_larynx_morphology0.94707276
116MP0003634_abnormal_glial_cell0.91090151
117MP0004085_abnormal_heartbeat0.89363241
118MP0003950_abnormal_plasma_membrane0.88969722
119MP0005645_abnormal_hypothalamus_physiol0.88765069
120MP0009703_decreased_birth_body0.87862672
121MP0009672_abnormal_birth_weight0.87043841
122MP0003136_yellow_coat_color0.86822806
123MP0004084_abnormal_cardiac_muscle0.86673100
124MP0004036_abnormal_muscle_relaxation0.85684314
125MP0002116_abnormal_craniofacial_bone0.85495145
126MP0002069_abnormal_eating/drinking_beha0.84957714
127MP0002938_white_spotting0.84668034
128MP0002081_perinatal_lethality0.84192226
129MP0003123_paternal_imprinting0.78556935
130MP0001270_distended_abdomen0.77283532
131MP0000566_synostosis0.75877193
132MP0005623_abnormal_meninges_morphology0.75255170
133MP0003137_abnormal_impulse_conducting0.74292809
134MP0004484_altered_response_of0.73350588
135MP0004197_abnormal_fetal_growth/weight/0.72708556
136MP0003632_abnormal_nervous_system0.72381756
137MP0000920_abnormal_myelination0.70897414
138MP0002876_abnormal_thyroid_physiology0.70896013
139MP0000569_abnormal_digit_pigmentation0.70006716
140MP0001299_abnormal_eye_distance/0.68396696
141MP0000604_amyloidosis0.66250584
142MP0008874_decreased_physiological_sensi0.62589281
143MP0001664_abnormal_digestion0.62541850
144MP0000026_abnormal_inner_ear0.62312440
145MP0002653_abnormal_ependyma_morphology0.61885589
146MP0008872_abnormal_physiological_respon0.59127860

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.27656895
2Myokymia (HP:0002411)6.01369162
3Focal motor seizures (HP:0011153)5.95624275
4Epileptic encephalopathy (HP:0200134)4.63901480
5Atonic seizures (HP:0010819)4.52769604
6Bony spicule pigmentary retinopathy (HP:0007737)4.48589863
7Focal seizures (HP:0007359)4.48300390
8Febrile seizures (HP:0002373)4.25335220
9Absence seizures (HP:0002121)4.23929511
10Action tremor (HP:0002345)3.91927593
11Progressive cerebellar ataxia (HP:0002073)3.91523767
12Visual hallucinations (HP:0002367)3.91430989
13Central scotoma (HP:0000603)3.88621589
14Abnormality of macular pigmentation (HP:0008002)3.71640351
15Dialeptic seizures (HP:0011146)3.64318192
16Generalized tonic-clonic seizures (HP:0002069)3.52896665
17Hyperventilation (HP:0002883)3.43612159
18Scotoma (HP:0000575)3.42185940
19Congenital sensorineural hearing impairment (HP:0008527)3.40727118
20Concave nail (HP:0001598)3.35911207
21Dysdiadochokinesis (HP:0002075)3.14691057
22Depression (HP:0000716)3.11305912
23Amblyopia (HP:0000646)3.02333463
24High anterior hairline (HP:0009890)3.01425952
25Attenuation of retinal blood vessels (HP:0007843)2.87854007
26Exercise-induced myalgia (HP:0003738)2.85806293
27Anxiety (HP:0000739)2.84808609
28Absent eyebrow (HP:0002223)2.83742597
29Limb dystonia (HP:0002451)2.79462832
30Drooling (HP:0002307)2.75057984
31Excessive salivation (HP:0003781)2.75057984
32Broad-based gait (HP:0002136)2.73536558
33Truncal ataxia (HP:0002078)2.73381967
34Agitation (HP:0000713)2.68029583
35Mutism (HP:0002300)2.63325689
36Broad alveolar ridges (HP:0000187)2.59414338
37Thyroid-stimulating hormone excess (HP:0002925)2.57743760
38Supranuclear gaze palsy (HP:0000605)2.56757358
39Dysmetria (HP:0001310)2.54050061
40Abnormality of the pubic bones (HP:0003172)2.52860233
41Abnormal eating behavior (HP:0100738)2.48434937
42Ankle clonus (HP:0011448)2.48038979
43Polyphagia (HP:0002591)2.44194677
44Morphological abnormality of the middle ear (HP:0008609)2.42492063
45Intestinal atresia (HP:0011100)2.41872809
46Prolonged QT interval (HP:0001657)2.40751669
47Epileptiform EEG discharges (HP:0011182)2.39194793
48Curly hair (HP:0002212)2.37764824
49Abnormal hair whorl (HP:0010721)2.37522689
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37473570
51Hemiparesis (HP:0001269)2.34054921
52Pheochromocytoma (HP:0002666)2.33743626
53Megalencephaly (HP:0001355)2.32662675
54Chorioretinal atrophy (HP:0000533)2.31350769
55Gait imbalance (HP:0002141)2.31253109
56Aqueductal stenosis (HP:0002410)2.31208318
57EEG with generalized epileptiform discharges (HP:0011198)2.28934756
58Hypoventilation (HP:0002791)2.26945044
59Poor eye contact (HP:0000817)2.26891547
60Failure to thrive in infancy (HP:0001531)2.25540746
61Decreased central vision (HP:0007663)2.23205751
62Abnormal social behavior (HP:0012433)2.21973547
63Impaired social interactions (HP:0000735)2.21973547
64Cupped ear (HP:0000378)2.20158403
65Absent speech (HP:0001344)2.18068456
66Tubulointerstitial nephritis (HP:0001970)2.17216780
67Septo-optic dysplasia (HP:0100842)2.16097104
68Hypoplastic pelvis (HP:0008839)2.14841942
69Hyperthyroidism (HP:0000836)2.13845603
70Impaired vibration sensation in the lower limbs (HP:0002166)2.13829291
71Lissencephaly (HP:0001339)2.13374378
72Bifid tongue (HP:0010297)2.12913732
73Torticollis (HP:0000473)2.11036049
74Neuroendocrine neoplasm (HP:0100634)2.10734378
75Thickened helices (HP:0000391)2.09982416
76Abnormality of the intervertebral disk (HP:0005108)2.09605745
77Cortical dysplasia (HP:0002539)2.09512073
78Bicornuate uterus (HP:0000813)2.09085808
79Neonatal respiratory distress (HP:0002643)2.07763671
80Fibular aplasia (HP:0002990)2.06446186
81Focal dystonia (HP:0004373)2.06205215
82Alacrima (HP:0000522)2.06172054
83Bradykinesia (HP:0002067)2.01891812
84Gaze-evoked nystagmus (HP:0000640)2.00895376
85Cerebral inclusion bodies (HP:0100314)2.00104047
86Renal hypoplasia (HP:0000089)2.00070462
87Neurofibrillary tangles (HP:0002185)1.99682245
88Abnormality of the labia minora (HP:0012880)1.99063819
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98821972
90Buphthalmos (HP:0000557)1.98426776
91Abnormal EKG (HP:0003115)1.98337401
92Vitreoretinal degeneration (HP:0000655)1.97019641
93Abnormality of the antihelix (HP:0009738)1.96874321
94Intention tremor (HP:0002080)1.96831696
95Delusions (HP:0000746)1.96669022
96Patellar aplasia (HP:0006443)1.96064794
97Type II lissencephaly (HP:0007260)1.95904488
98Craniofacial dystonia (HP:0012179)1.94693046
99Spastic gait (HP:0002064)1.92887971
100Abnormality of the corticospinal tract (HP:0002492)1.92748536
101Generalized myoclonic seizures (HP:0002123)1.92646816
102Narrow forehead (HP:0000341)1.92519699
103Congenital primary aphakia (HP:0007707)1.92393571
104Abnormality of binocular vision (HP:0011514)1.92299140
105Diplopia (HP:0000651)1.92299140
106Specific learning disability (HP:0001328)1.92161013
107Scanning speech (HP:0002168)1.92073508
108Abnormal rod and cone electroretinograms (HP:0008323)1.92014600
109Chronic hepatic failure (HP:0100626)1.90112336
110Abnormality of the parathyroid morphology (HP:0011766)1.89858111
111Decreased lacrimation (HP:0000633)1.89611521
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87754748
113Hypoplasia of the brainstem (HP:0002365)1.87754748
114Growth hormone deficiency (HP:0000824)1.87557468
115Nephrogenic diabetes insipidus (HP:0009806)1.87517899
116Micropenis (HP:0000054)1.87300834
117Urinary bladder sphincter dysfunction (HP:0002839)1.85801119
118Macroorchidism (HP:0000053)1.84975259
119Inability to walk (HP:0002540)1.84719419
120Open mouth (HP:0000194)1.84616427
121Progressive inability to walk (HP:0002505)1.83114010
122Urinary urgency (HP:0000012)1.82419850
123Aplasia/Hypoplasia of the patella (HP:0006498)1.81805158
124Neoplasm of the adrenal cortex (HP:0100641)1.80802811
125Abnormality of dental color (HP:0011073)1.80636853
126Hypsarrhythmia (HP:0002521)1.80631666
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.80103118
128Medial flaring of the eyebrow (HP:0010747)1.80042832
129Neoplasm of the heart (HP:0100544)1.79935277
130Termporal pattern (HP:0011008)1.79723703
131Insidious onset (HP:0003587)1.79723703
132Blue irides (HP:0000635)1.79658020
133Occipital encephalocele (HP:0002085)1.79640463
134Pachygyria (HP:0001302)1.79603904
135Abnormality of the lower motor neuron (HP:0002366)1.79537437
136Optic nerve hypoplasia (HP:0000609)1.78650045
137Abnormality of salivation (HP:0100755)1.77852655
138Hypoplasia of the corpus callosum (HP:0002079)1.77501239
139Stereotypic behavior (HP:0000733)1.75151632
140Retinitis pigmentosa (HP:0000510)1.74962130
141Oligomenorrhea (HP:0000876)1.74912200
142Spina bifida occulta (HP:0003298)1.73868293
143Partial agenesis of the corpus callosum (HP:0001338)1.73508698
144Oligodactyly (HP:0012165)1.71548098
145Hemivertebrae (HP:0002937)1.71392386
146Nephronophthisis (HP:0000090)1.71331076
147Genital tract atresia (HP:0001827)1.70167919
148Renal dysplasia (HP:0000110)1.69619309
149Oligodactyly (hands) (HP:0001180)1.69348510
150Genetic anticipation (HP:0003743)1.69121934
151Cerebellar dysplasia (HP:0007033)1.67690405
152Postaxial hand polydactyly (HP:0001162)1.67598555
153Absent hair (HP:0002298)1.67449608
154Hepatoblastoma (HP:0002884)1.66448673
155Status epilepticus (HP:0002133)1.65207241
156Double outlet right ventricle (HP:0001719)1.64907510
157Congenital malformation of the right heart (HP:0011723)1.64907510
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.64729094
159Delayed CNS myelination (HP:0002188)1.63435201
160Poor suck (HP:0002033)1.63402228
161Retinal dysplasia (HP:0007973)1.62976077
162Vaginal atresia (HP:0000148)1.62754471
163Cutaneous finger syndactyly (HP:0010554)1.60961988
164Complete atrioventricular canal defect (HP:0001674)1.60953799
165Polymicrogyria (HP:0002126)1.60309530
166Optic nerve coloboma (HP:0000588)1.59585655
167Atrioventricular canal defect (HP:0006695)1.56837407
168Anophthalmia (HP:0000528)1.56300112
169Short philtrum (HP:0000322)1.56009182
170Choanal stenosis (HP:0000452)1.55136141
171Synostosis involving the elbow (HP:0003938)1.54858302
172Humeroradial synostosis (HP:0003041)1.54858302
173Decreased testicular size (HP:0008734)1.53465025
174Amyotrophic lateral sclerosis (HP:0007354)1.53162032
175Generalized hypotonia (HP:0001290)1.53071623
176Midline defect of the nose (HP:0004122)1.53032396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.32249742
2NTRK33.64014954
3TRIM283.23530492
4MAP3K43.12721236
5MAP3K93.09318410
6WNK33.04099735
7PRPF4B3.01905542
8MARK12.88736736
9CASK2.67965234
10PHKG22.61460464
11PHKG12.61460464
12MAP2K72.47279120
13MINK12.43152687
14MAP4K22.38074043
15EPHB22.24088300
16PAK62.21520662
17KSR22.19231549
18MAP2K42.06103723
19NTRK21.92534809
20NTRK11.88152401
21AKT31.86497884
22PKN21.84452750
23FGFR21.79342462
24PAK31.73706386
25TESK21.68583101
26EPHA31.67565611
27DAPK21.66811835
28DYRK31.61594458
29KSR11.59328302
30TYRO31.58239539
31FRK1.57116333
32SRPK11.54398098
33ARAF1.52190061
34PLK21.48274564
35CSNK1A1L1.47629277
36DYRK21.47604200
37FES1.46289275
38RPS6KA41.43091887
39BRD41.42958796
40TAOK21.31669257
41CSNK1G11.30744404
42CDK51.27434858
43TNIK1.26701266
44PNCK1.15765802
45DYRK1A1.11735252
46CAMK1G1.11081320
47CAMKK11.10751096
48PBK1.07651245
49MAP3K21.06136841
50MAPK131.06017034
51MAP3K121.04711471
52BCKDK1.04699918
53MAP3K61.04179922
54GRK51.03671582
55PRKCG1.03577270
56IRAK21.02634636
57STK38L1.02303983
58STK380.99954552
59RAF10.98321713
60CAMK2A0.97974938
61SIK30.95970913
62DYRK1B0.94986125
63RIPK40.91130804
64UHMK10.90407308
65ERBB20.86339592
66STK110.83806208
67PIK3CA0.82558002
68CDK140.82531901
69CDK190.81513423
70CDK180.76192992
71PTK2B0.75494828
72CDK150.74815589
73SIK20.73620812
74RET0.71703832
75FGR0.71503092
76PRKCE0.70032279
77OXSR10.69995520
78MAP3K130.69423402
79CSNK1G20.69089178
80DAPK10.68914480
81SGK2230.68397136
82SGK4940.68397136
83PRKD30.67460731
84NEK60.67187756
85MUSK0.65675811
86CAMK2B0.63788964
87LMTK20.63414417
88INSRR0.62906706
89CDK11A0.61899580
90LATS20.60544750
91CAMK1D0.60451432
92SGK30.59906392
93ROCK20.58836814
94CAMK2D0.58571171
95FER0.57692684
96BCR0.57420895
97CAMKK20.56549771
98TRIB30.56435587
99FGFR10.56117416
100WNK10.54878107
101TESK10.54568755
102PDGFRA0.54130491
103ILK0.53718925
104CDK30.52509011
105CSNK1D0.51622187
106PRKCZ0.51157330
107CAMK10.50873702
108NME10.50084763
109RPS6KA30.50048021
110PINK10.49859757
111FYN0.46750264
112CDK90.46518734
113RPS6KA20.46395646
114PLK30.46062915
115MARK20.45830843
116CAMK40.44063279
117PKN10.42992161
118LATS10.42557066
119ERBB30.40937726
120CAMK2G0.40410867
121CSNK1G30.39684092
122SGK10.39584802
123STK390.39563882
124MAP2K10.38040266
125CCNB10.37982087
126PRKCH0.37611895
127SGK20.36615918
128PRKD20.35650233
129PRKCB0.34666287
130MAPK90.34141907
131MAP3K70.33840826
132PRKAA10.33779382
133ROCK10.33421042
134CSNK1E0.33405421
135PRKACA0.33144791
136BMPR20.32963259
137CSNK1A10.32764087
138GSK3B0.31818593
139SIK10.30445877
140ERBB40.29860224
141MAPK80.29591583
142MAPK100.29571999
143PRKACB0.28915855
144CDK10.27506142

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98291406
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48685929
3GABAergic synapse_Homo sapiens_hsa047273.02040449
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87297610
5Morphine addiction_Homo sapiens_hsa050322.62127998
6Circadian entrainment_Homo sapiens_hsa047132.48552284
7Glutamatergic synapse_Homo sapiens_hsa047242.39572269
8Olfactory transduction_Homo sapiens_hsa047402.35437635
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.27623240
10Steroid biosynthesis_Homo sapiens_hsa001002.27390366
11Dopaminergic synapse_Homo sapiens_hsa047282.22288051
12Long-term potentiation_Homo sapiens_hsa047202.13784051
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04477019
14Amphetamine addiction_Homo sapiens_hsa050312.04273916
15Phototransduction_Homo sapiens_hsa047441.94880787
16Salivary secretion_Homo sapiens_hsa049701.94466371
17Cholinergic synapse_Homo sapiens_hsa047251.94073758
18Insulin secretion_Homo sapiens_hsa049111.91025769
19Serotonergic synapse_Homo sapiens_hsa047261.82855529
20Collecting duct acid secretion_Homo sapiens_hsa049661.75256368
21Long-term depression_Homo sapiens_hsa047301.73066801
22Taste transduction_Homo sapiens_hsa047421.69606233
23Renin secretion_Homo sapiens_hsa049241.68716750
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59932438
25Hippo signaling pathway_Homo sapiens_hsa043901.56042539
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55330773
27Basal cell carcinoma_Homo sapiens_hsa052171.53696580
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52081339
29Cocaine addiction_Homo sapiens_hsa050301.49014829
30Oxytocin signaling pathway_Homo sapiens_hsa049211.48407657
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47684382
32Calcium signaling pathway_Homo sapiens_hsa040201.45489398
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42933860
34GnRH signaling pathway_Homo sapiens_hsa049121.36556694
35Gastric acid secretion_Homo sapiens_hsa049711.36329502
36Axon guidance_Homo sapiens_hsa043601.36287319
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34511866
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29352189
39AMPK signaling pathway_Homo sapiens_hsa041521.23762128
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23598588
41Protein export_Homo sapiens_hsa030601.23019724
42Vibrio cholerae infection_Homo sapiens_hsa051101.21381767
43Tight junction_Homo sapiens_hsa045301.20144883
44Gap junction_Homo sapiens_hsa045401.19967413
45Cardiac muscle contraction_Homo sapiens_hsa042601.18674102
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16868688
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14755429
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12643729
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10144328
50Colorectal cancer_Homo sapiens_hsa052101.09458091
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06816355
52Type II diabetes mellitus_Homo sapiens_hsa049301.05329528
53cAMP signaling pathway_Homo sapiens_hsa040241.03416747
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03232065
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02560187
56Lysine degradation_Homo sapiens_hsa003101.00715521
57Basal transcription factors_Homo sapiens_hsa030220.99916170
58Melanoma_Homo sapiens_hsa052180.98256423
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96611743
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96205798
61Propanoate metabolism_Homo sapiens_hsa006400.94289212
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94007056
63Melanogenesis_Homo sapiens_hsa049160.92131628
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91870531
65ErbB signaling pathway_Homo sapiens_hsa040120.90963476
66Notch signaling pathway_Homo sapiens_hsa043300.87932491
67Estrogen signaling pathway_Homo sapiens_hsa049150.87153702
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.87124076
69Dilated cardiomyopathy_Homo sapiens_hsa054140.86390130
70Glioma_Homo sapiens_hsa052140.84107822
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.81755362
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78801321
73Choline metabolism in cancer_Homo sapiens_hsa052310.75331926
74Adherens junction_Homo sapiens_hsa045200.75057291
75Fatty acid biosynthesis_Homo sapiens_hsa000610.72221764
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71925805
77Mineral absorption_Homo sapiens_hsa049780.71902553
78Selenocompound metabolism_Homo sapiens_hsa004500.71533220
79Regulation of autophagy_Homo sapiens_hsa041400.71352553
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70102071
81Inositol phosphate metabolism_Homo sapiens_hsa005620.70002263
82Circadian rhythm_Homo sapiens_hsa047100.69300572
83Pancreatic secretion_Homo sapiens_hsa049720.68690780
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67858979
85Fatty acid metabolism_Homo sapiens_hsa012120.66325344
86Oocyte meiosis_Homo sapiens_hsa041140.66139534
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63798532
88Glucagon signaling pathway_Homo sapiens_hsa049220.63745955
89Dorso-ventral axis formation_Homo sapiens_hsa043200.62848987
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60015450
91TGF-beta signaling pathway_Homo sapiens_hsa043500.59908983
92Thyroid hormone synthesis_Homo sapiens_hsa049180.59103764
93Ras signaling pathway_Homo sapiens_hsa040140.58865023
94ABC transporters_Homo sapiens_hsa020100.58685796
95Prolactin signaling pathway_Homo sapiens_hsa049170.57982697
96Alzheimers disease_Homo sapiens_hsa050100.56637655
97VEGF signaling pathway_Homo sapiens_hsa043700.56462323
98Bile secretion_Homo sapiens_hsa049760.55480816
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.55061086
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54306776
101MAPK signaling pathway_Homo sapiens_hsa040100.54091077
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.53651058
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.53585001
104Ovarian steroidogenesis_Homo sapiens_hsa049130.51523928
105Oxidative phosphorylation_Homo sapiens_hsa001900.51417758
106Renal cell carcinoma_Homo sapiens_hsa052110.50186420
107Alcoholism_Homo sapiens_hsa050340.48705385
108Prostate cancer_Homo sapiens_hsa052150.48452347
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47909858
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47646015
111RNA polymerase_Homo sapiens_hsa030200.47335747
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47070321
113Sulfur metabolism_Homo sapiens_hsa009200.46595235
114Endometrial cancer_Homo sapiens_hsa052130.46260571
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45299951
116Rap1 signaling pathway_Homo sapiens_hsa040150.43941613
117Biosynthesis of amino acids_Homo sapiens_hsa012300.43621818
118Prion diseases_Homo sapiens_hsa050200.43153352
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39935346
120Insulin signaling pathway_Homo sapiens_hsa049100.39542650
121Non-small cell lung cancer_Homo sapiens_hsa052230.39070453
122Hedgehog signaling pathway_Homo sapiens_hsa043400.38437242
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38052116
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37454026
125Wnt signaling pathway_Homo sapiens_hsa043100.37222224
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37104123
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37005920
128Butanoate metabolism_Homo sapiens_hsa006500.35815686
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.33090746
130mTOR signaling pathway_Homo sapiens_hsa041500.29777447
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28845563
132Endocytosis_Homo sapiens_hsa041440.25711460
133Rheumatoid arthritis_Homo sapiens_hsa053230.24582448
134Parkinsons disease_Homo sapiens_hsa050120.23999824
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22997381
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22120207
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21722686

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