PCDHB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06926740
2synaptic vesicle exocytosis (GO:0016079)4.86568444
3vocalization behavior (GO:0071625)4.75004872
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56853962
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50005679
6response to pheromone (GO:0019236)4.37200738
7neuron cell-cell adhesion (GO:0007158)4.26862831
8synaptic vesicle maturation (GO:0016188)4.18143987
9negative regulation of cytosolic calcium ion concentration (GO:0051481)4.14708119
10glutamate secretion (GO:0014047)4.13000333
11long term synaptic depression (GO:0060292)4.11000179
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08332647
13locomotory exploration behavior (GO:0035641)4.03264564
14presynaptic membrane organization (GO:0097090)3.95387797
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94469315
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.83796634
17long-term synaptic potentiation (GO:0060291)3.80724072
18single strand break repair (GO:0000012)3.78988799
19negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73988430
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.72228944
21regulation of synaptic vesicle exocytosis (GO:2000300)3.72180924
22protein localization to synapse (GO:0035418)3.68883081
23nucleobase catabolic process (GO:0046113)3.68407653
24neuron recognition (GO:0008038)3.67336976
25regulation of glutamate receptor signaling pathway (GO:1900449)3.64642634
26axonal fasciculation (GO:0007413)3.60943835
27exploration behavior (GO:0035640)3.59040162
28neurotransmitter-gated ion channel clustering (GO:0072578)3.58507531
29neuron-neuron synaptic transmission (GO:0007270)3.54409335
30synaptic transmission, glutamatergic (GO:0035249)3.53398752
31glutamate receptor signaling pathway (GO:0007215)3.52263076
32dendrite morphogenesis (GO:0048813)3.48665029
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48011021
34* synapse assembly (GO:0007416)3.47268244
35protein localization to cilium (GO:0061512)3.46388420
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.40392020
37neurotransmitter secretion (GO:0007269)3.36667266
38positive regulation of synapse maturation (GO:0090129)3.32543262
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.30441671
40auditory behavior (GO:0031223)3.25139351
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23733104
42glycerophospholipid catabolic process (GO:0046475)3.22936109
43positive regulation of neurotransmitter transport (GO:0051590)3.20267104
44dendritic spine morphogenesis (GO:0060997)3.20154416
45regulation of glucocorticoid secretion (GO:2000849)3.19726640
46gamma-aminobutyric acid transport (GO:0015812)3.14070968
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13298457
48cell migration in hindbrain (GO:0021535)3.12865144
49regulation of neuronal synaptic plasticity (GO:0048168)3.11385800
50cerebral cortex radially oriented cell migration (GO:0021799)3.11259163
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11112147
52cellular potassium ion homeostasis (GO:0030007)3.10663433
53behavioral response to nicotine (GO:0035095)3.10046803
54layer formation in cerebral cortex (GO:0021819)3.09165221
55regulation of dendritic spine morphogenesis (GO:0061001)3.09059338
56long-term memory (GO:0007616)3.08948911
57innervation (GO:0060384)3.07591992
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07546427
59regulation of synaptic vesicle transport (GO:1902803)3.07351696
60positive regulation of membrane potential (GO:0045838)3.06071476
61cerebellar granule cell differentiation (GO:0021707)3.05612395
62protein-chromophore linkage (GO:0018298)3.04438754
63dendrite development (GO:0016358)3.02096059
64regulation of postsynaptic membrane potential (GO:0060078)2.99802280
65neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.97584288
66neuronal action potential propagation (GO:0019227)2.92540504
67central nervous system projection neuron axonogenesis (GO:0021952)2.92446882
68positive regulation of dendritic spine morphogenesis (GO:0061003)2.92089859
69negative regulation of microtubule polymerization (GO:0031115)2.88797717
70regulation of vesicle fusion (GO:0031338)2.88759390
71regulation of synapse maturation (GO:0090128)2.88651191
72regulation of neurotransmitter uptake (GO:0051580)2.88260845
73transmission of nerve impulse (GO:0019226)2.87962350
74neurotransmitter transport (GO:0006836)2.87774100
75regulation of synapse structural plasticity (GO:0051823)2.87237838
76behavioral response to cocaine (GO:0048148)2.86874309
77negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.86290818
78postsynaptic membrane organization (GO:0001941)2.85867426
79pyrimidine nucleobase catabolic process (GO:0006208)2.85795276
80regulation of synaptic plasticity (GO:0048167)2.85557544
81cGMP-mediated signaling (GO:0019934)2.83739969
82membrane hyperpolarization (GO:0060081)2.83250997
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82532020
84atrial cardiac muscle cell action potential (GO:0086014)2.82488070
85positive regulation of neurotransmitter secretion (GO:0001956)2.80867130
86* synapse organization (GO:0050808)2.80416048
87membrane depolarization during action potential (GO:0086010)2.80124934
88regulation of voltage-gated calcium channel activity (GO:1901385)2.79492869
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79181413
90negative regulation of synaptic transmission (GO:0050805)2.79060768
91behavioral defense response (GO:0002209)2.78902542
92behavioral fear response (GO:0001662)2.78902542
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78467164
94* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78385167
95positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.78019862
96positive regulation of synapse assembly (GO:0051965)2.78014949
97regulation of corticosteroid hormone secretion (GO:2000846)2.77367174
98* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.73849640
99negative regulation of neurotransmitter transport (GO:0051589)2.72666404
100neuronal ion channel clustering (GO:0045161)2.72331004
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72004029
102membrane depolarization (GO:0051899)2.71147342
103response to histamine (GO:0034776)2.70806319
104proline transport (GO:0015824)2.70746737
105presynaptic membrane assembly (GO:0097105)2.70428921
106regulation of action potential (GO:0098900)2.70344853
107sequestering of extracellular ligand from receptor (GO:0035581)2.70074409
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.67871292
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67847292
110cochlea development (GO:0090102)2.67458870
111establishment of mitochondrion localization (GO:0051654)2.67226327
112activation of protein kinase A activity (GO:0034199)2.66644923
113learning (GO:0007612)2.65673460
114regulation of neurotransmitter levels (GO:0001505)2.64678863
115negative regulation of complement activation (GO:0045916)2.63876233
116fear response (GO:0042596)2.63256132
117* synaptic transmission (GO:0007268)2.63130639
118mechanosensory behavior (GO:0007638)2.63120496
119positive regulation of dendritic spine development (GO:0060999)2.60941221
120positive regulation of action potential (GO:0045760)2.55410343
121regulation of neurotransmitter transport (GO:0051588)2.54332324
122multicellular organismal signaling (GO:0035637)2.52888781
123substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52333956
124substrate-independent telencephalic tangential migration (GO:0021826)2.52333956
125potassium ion homeostasis (GO:0055075)2.52293537
126positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52137014
127nonmotile primary cilium assembly (GO:0035058)2.50162884
128glycosphingolipid biosynthetic process (GO:0006688)2.50064920
129neuromuscular synaptic transmission (GO:0007274)2.49873919
130retinal ganglion cell axon guidance (GO:0031290)2.48514825
131adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.47408483
132short-term memory (GO:0007614)2.47340321
133alanine transport (GO:0032328)2.47203701
134neuron maturation (GO:0042551)2.46299007
135regulation of respiratory system process (GO:0044065)2.46183278
136potassium ion import (GO:0010107)2.45571540
137dopamine biosynthetic process (GO:0042416)2.44894949
138regulation of membrane repolarization (GO:0060306)2.44390970
139calcium ion import (GO:0070509)2.43867446
140positive regulation of amine transport (GO:0051954)2.42069591
141cerebellar Purkinje cell layer development (GO:0021680)2.41781690
142behavioral response to ethanol (GO:0048149)2.41661438
143regulation of neurotransmitter secretion (GO:0046928)2.40816490
144regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.37781253
145regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.37781253
146detection of calcium ion (GO:0005513)2.36823306
147regulation of heart rate by cardiac conduction (GO:0086091)2.36622696
148phasic smooth muscle contraction (GO:0014821)2.35846543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50594366
2GBX2_23144817_ChIP-Seq_PC3_Human4.01506619
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18343387
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97492095
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88359727
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70108090
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59500555
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59135110
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55933452
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55933452
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55474227
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.47800596
13DROSHA_22980978_ChIP-Seq_HELA_Human2.45730106
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.45316140
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43682193
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40794425
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37700128
18REST_21632747_ChIP-Seq_MESCs_Mouse2.28465002
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17430461
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.14435176
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14202038
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06276906
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01607500
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96188342
25NR3C1_23031785_ChIP-Seq_PC12_Mouse1.94442518
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.90863809
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90813218
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.88954645
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.88490064
30AR_21572438_ChIP-Seq_LNCaP_Human1.86754600
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78264664
32TAF15_26573619_Chip-Seq_HEK293_Human1.68361109
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65972502
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61814481
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59849269
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.59635193
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58063984
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57689276
39P300_19829295_ChIP-Seq_ESCs_Human1.56967557
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.56056243
41VDR_22108803_ChIP-Seq_LS180_Human1.55675356
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54764986
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.53304726
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53297446
45TP53_18474530_ChIP-ChIP_U2OS_Human1.52602584
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52451554
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46674106
48AR_25329375_ChIP-Seq_VCAP_Human1.44439899
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43225318
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.42994243
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.42813680
52IGF1R_20145208_ChIP-Seq_DFB_Human1.40824942
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.40750139
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36029886
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35000005
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34534005
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34072182
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.33247109
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32189250
60BCAT_22108803_ChIP-Seq_LS180_Human1.29513941
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27509864
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25396866
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.24185341
64TP53_16413492_ChIP-PET_HCT116_Human1.23254957
65ZNF274_21170338_ChIP-Seq_K562_Hela1.21948597
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21427681
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20343973
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19336136
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18234860
70ER_23166858_ChIP-Seq_MCF-7_Human1.17334772
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17253087
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.14714149
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14629970
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.14160461
75P53_22387025_ChIP-Seq_ESCs_Mouse1.13445995
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12535086
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12535086
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11966744
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11477358
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11023521
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10044653
82STAT3_23295773_ChIP-Seq_U87_Human1.09763310
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09052564
84CBP_20019798_ChIP-Seq_JUKART_Human1.09052564
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.08633723
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08486456
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08183419
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.07192672
89TCF4_23295773_ChIP-Seq_U87_Human1.07055951
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.06601504
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.06066517
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05652852
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.05345515
94EWS_26573619_Chip-Seq_HEK293_Human1.04909768
95AR_19668381_ChIP-Seq_PC3_Human1.04580760
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04417655
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.03569046
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03332902
99TCF4_22108803_ChIP-Seq_LS180_Human1.03186864
100* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02865181
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.02304327
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.01997646
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01889782
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01774798
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99965579
106RUNX2_22187159_ChIP-Seq_PCA_Human0.99841835
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.98863692
108HTT_18923047_ChIP-ChIP_STHdh_Human0.98638098
109JUN_21703547_ChIP-Seq_K562_Human0.98265825
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97847797
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97026790
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95460999
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94842120
114RNF2_27304074_Chip-Seq_NSC_Mouse0.93960578
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93845028
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93845028
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92980687
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.92454742
119AHR_22903824_ChIP-Seq_MCF-7_Human0.92363259
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91885146
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91496383
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.91132997
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90412798
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89086660
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87113963
126FUS_26573619_Chip-Seq_HEK293_Human0.86893207
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86761256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46169638
2MP0003880_abnormal_central_pattern4.12339213
3MP0002736_abnormal_nociception_after3.54806437
4MP0003635_abnormal_synaptic_transmissio3.45731070
5MP0001968_abnormal_touch/_nociception3.40548023
6MP0004270_analgesia3.24048602
7MP0002638_abnormal_pupillary_reflex3.02320982
8MP0009745_abnormal_behavioral_response2.77209486
9MP0002064_seizures2.61254787
10MP0002063_abnormal_learning/memory/cond2.59361677
11MP0009046_muscle_twitch2.55467462
12MP0002734_abnormal_mechanical_nocicepti2.46911632
13MP0001486_abnormal_startle_reflex2.44738216
14MP0002572_abnormal_emotion/affect_behav2.17458192
15MP0001529_abnormal_vocalization2.15235292
16MP0002822_catalepsy2.13295458
17MP0002272_abnormal_nervous_system2.10645091
18MP0004858_abnormal_nervous_system2.01897628
19MP0001502_abnormal_circadian_rhythm1.97188354
20MP0000778_abnormal_nervous_system1.96287558
21MP0006276_abnormal_autonomic_nervous1.88233380
22MP0002184_abnormal_innervation1.87631068
23MP0005423_abnormal_somatic_nervous1.87351750
24MP0002735_abnormal_chemical_nociception1.86884288
25MP0005379_endocrine/exocrine_gland_phen1.80718819
26MP0004924_abnormal_behavior1.75367410
27MP0005386_behavior/neurological_phenoty1.75367410
28MP0002067_abnormal_sensory_capabilities1.75214424
29MP0004885_abnormal_endolymph1.74741315
30MP0002733_abnormal_thermal_nociception1.73068724
31MP0001440_abnormal_grooming_behavior1.72079324
32MP0008569_lethality_at_weaning1.70238195
33MP0005551_abnormal_eye_electrophysiolog1.67543502
34MP0001970_abnormal_pain_threshold1.63099036
35MP0001188_hyperpigmentation1.58431906
36MP0004233_abnormal_muscle_weight1.57404746
37MP0004133_heterotaxia1.54717094
38MP0001501_abnormal_sleep_pattern1.54545979
39MP0002557_abnormal_social/conspecific_i1.53951381
40MP0000955_abnormal_spinal_cord1.39940140
41MP0004811_abnormal_neuron_physiology1.39099692
42MP0004142_abnormal_muscle_tone1.38877928
43MP0005645_abnormal_hypothalamus_physiol1.35981207
44MP0005409_darkened_coat_color1.35351586
45MP0003879_abnormal_hair_cell1.34524915
46MP0001905_abnormal_dopamine_level1.33429610
47MP0002882_abnormal_neuron_morphology1.33150526
48MP0003787_abnormal_imprinting1.30918222
49MP0000751_myopathy1.28882893
50MP0002090_abnormal_vision1.28329262
51MP0002837_dystrophic_cardiac_calcinosis1.26291246
52MP0002909_abnormal_adrenal_gland1.25117739
53MP0008877_abnormal_DNA_methylation1.24387596
54MP0002066_abnormal_motor_capabilities/c1.22429399
55MP0001986_abnormal_taste_sensitivity1.21369150
56MP0001944_abnormal_pancreas_morphology1.19813081
57MP0001984_abnormal_olfaction1.17766468
58MP0010386_abnormal_urinary_bladder1.16564770
59MP0003690_abnormal_glial_cell1.13594736
60MP0006072_abnormal_retinal_apoptosis1.13092303
61MP0004742_abnormal_vestibular_system1.11889065
62MP0005623_abnormal_meninges_morphology1.11184231
63MP0005646_abnormal_pituitary_gland1.10521626
64MP0005499_abnormal_olfactory_system1.09295370
65MP0005394_taste/olfaction_phenotype1.09295370
66MP0002876_abnormal_thyroid_physiology1.08096485
67MP0009384_cardiac_valve_regurgitation1.05358530
68MP0006292_abnormal_olfactory_placode1.04880590
69MP0003121_genomic_imprinting1.03776837
70MP0003329_amyloid_beta_deposits1.03397236
71MP0005171_absent_coat_pigmentation1.03138462
72MP0002938_white_spotting1.03050391
73MP0001849_ear_inflammation1.02168153
74MP0000631_abnormal_neuroendocrine_gland1.01515811
75MP0009780_abnormal_chondrocyte_physiolo1.01410265
76MP0003633_abnormal_nervous_system1.01324273
77MP0002752_abnormal_somatic_nervous1.00794503
78MP0004085_abnormal_heartbeat0.99747692
79MP0002152_abnormal_brain_morphology0.98379684
80MP0002229_neurodegeneration0.96481087
81MP0005253_abnormal_eye_physiology0.96222941
82MP0008789_abnormal_olfactory_epithelium0.95590327
83MP0002234_abnormal_pharynx_morphology0.94951272
84MP0000569_abnormal_digit_pigmentation0.94854868
85MP0004043_abnormal_pH_regulation0.94341066
86MP0004215_abnormal_myocardial_fiber0.93881151
87MP0001299_abnormal_eye_distance/0.93245369
88MP0001485_abnormal_pinna_reflex0.92917870
89MP0001963_abnormal_hearing_physiology0.92762151
90MP0003631_nervous_system_phenotype0.92711862
91MP0003634_abnormal_glial_cell0.91156787
92MP0003045_fibrosis0.90810649
93MP0002163_abnormal_gland_morphology0.89116342
94MP0008872_abnormal_physiological_respon0.88592972
95MP0004147_increased_porphyrin_level0.87932773
96MP0003137_abnormal_impulse_conducting0.85432215
97MP0004145_abnormal_muscle_electrophysio0.84527801
98MP0000639_abnormal_adrenal_gland0.84063170
99MP0000920_abnormal_myelination0.83865046
100MP0002751_abnormal_autonomic_nervous0.83416544
101MP0005248_abnormal_Harderian_gland0.83020553
102MP0010329_abnormal_lipoprotein_level0.82446534
103MP0003122_maternal_imprinting0.81949560
104MP0000678_abnormal_parathyroid_gland0.80984029
105MP0002693_abnormal_pancreas_physiology0.79772311
106MP0001756_abnormal_urination0.78213147
107MP0002069_abnormal_eating/drinking_beha0.76838349
108MP0005195_abnormal_posterior_eye0.76247028
109MP0003011_delayed_dark_adaptation0.76220727
110MP0001177_atelectasis0.76175167
111MP0005187_abnormal_penis_morphology0.75092509
112MP0002078_abnormal_glucose_homeostasis0.73956075
113MP0003632_abnormal_nervous_system0.72933299
114MP0003195_calcinosis0.71605248
115MP0005448_abnormal_energy_balance0.71045834
116MP0000013_abnormal_adipose_tissue0.71014686
117MP0004130_abnormal_muscle_cell0.69069774
118MP0000026_abnormal_inner_ear0.68522382
119MP0005084_abnormal_gallbladder_morpholo0.68470457
120MP0001270_distended_abdomen0.66680030
121MP0004484_altered_response_of0.65250748
122MP0008874_decreased_physiological_sensi0.60447627
123MP0003861_abnormal_nervous_system0.60054485

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.34562512
2Epileptic encephalopathy (HP:0200134)5.24576734
3Congenital stationary night blindness (HP:0007642)5.03048683
4Focal seizures (HP:0007359)4.57228600
5Visual hallucinations (HP:0002367)4.54930701
6Myokymia (HP:0002411)4.50443618
7Enlarged kidneys (HP:0000105)4.09407546
8Blue irides (HP:0000635)3.90988907
9Action tremor (HP:0002345)3.70393829
10Febrile seizures (HP:0002373)3.66575025
11Atonic seizures (HP:0010819)3.60439936
12Progressive inability to walk (HP:0002505)3.58731967
13Hemiparesis (HP:0001269)3.48109349
14Double outlet right ventricle (HP:0001719)3.47590816
15Congenital malformation of the right heart (HP:0011723)3.47590816
16Absence seizures (HP:0002121)3.45575009
17Progressive cerebellar ataxia (HP:0002073)3.30032088
18Generalized tonic-clonic seizures (HP:0002069)3.29992725
19Intestinal atresia (HP:0011100)3.27887124
20Hyperventilation (HP:0002883)3.20695255
21Mutism (HP:0002300)3.19784698
22Central scotoma (HP:0000603)3.09001183
23Scotoma (HP:0000575)3.02693624
24Dialeptic seizures (HP:0011146)3.00602188
25True hermaphroditism (HP:0010459)3.00046634
26Pancreatic fibrosis (HP:0100732)2.98190609
27Agitation (HP:0000713)2.93530882
28Epileptiform EEG discharges (HP:0011182)2.91878677
29EEG with generalized epileptiform discharges (HP:0011198)2.85188927
30Broad-based gait (HP:0002136)2.79221861
31Pheochromocytoma (HP:0002666)2.76333408
32Limb dystonia (HP:0002451)2.76215949
33Pancreatic cysts (HP:0001737)2.70742921
34Hypothermia (HP:0002045)2.70214790
35Amblyopia (HP:0000646)2.64500680
36Anxiety (HP:0000739)2.62668620
37Hypsarrhythmia (HP:0002521)2.60858554
38Poor eye contact (HP:0000817)2.58082099
39Medial flaring of the eyebrow (HP:0010747)2.55931728
40Nephronophthisis (HP:0000090)2.55899400
41Dysmetria (HP:0001310)2.54270665
42Fetal akinesia sequence (HP:0001989)2.50240268
43Type II lissencephaly (HP:0007260)2.49605454
44Ankle clonus (HP:0011448)2.47946744
45Depression (HP:0000716)2.47726316
46Congenital sensorineural hearing impairment (HP:0008527)2.46802641
47Drooling (HP:0002307)2.45437223
48Excessive salivation (HP:0003781)2.45437223
49Poor coordination (HP:0002370)2.39659670
50Aortic valve stenosis (HP:0001650)2.39198600
51Delayed gross motor development (HP:0002194)2.38292600
52Impaired social interactions (HP:0000735)2.38161566
53Abnormal social behavior (HP:0012433)2.38161566
54Cerebral hypomyelination (HP:0006808)2.38101733
55Intention tremor (HP:0002080)2.37968057
56Retinal dysplasia (HP:0007973)2.34533633
57Esophageal atresia (HP:0002032)2.33178813
58Truncal ataxia (HP:0002078)2.32871340
59Inability to walk (HP:0002540)2.32845813
60Gait imbalance (HP:0002141)2.31726111
61Exotropia (HP:0000577)2.30428418
62Supranuclear gaze palsy (HP:0000605)2.29181267
63Hypoventilation (HP:0002791)2.29067136
64Pulmonic stenosis (HP:0001642)2.28978666
65Termporal pattern (HP:0011008)2.26639280
66Insidious onset (HP:0003587)2.26639280
67Nephrogenic diabetes insipidus (HP:0009806)2.26223751
68Severe Myopia (HP:0011003)2.25777157
69Lipid accumulation in hepatocytes (HP:0006561)2.24429109
70Dysdiadochokinesis (HP:0002075)2.22081341
71Methylmalonic acidemia (HP:0002912)2.21766318
72Abnormal eating behavior (HP:0100738)2.20607593
73Genetic anticipation (HP:0003743)2.19737939
74Absent speech (HP:0001344)2.19641868
75Large for gestational age (HP:0001520)2.18933260
76Prominent supraorbital ridges (HP:0000336)2.18827157
77Abnormality of the renal medulla (HP:0100957)2.16196742
78Polydipsia (HP:0001959)2.16157053
79Abnormal drinking behavior (HP:0030082)2.16157053
80Spastic gait (HP:0002064)2.13120982
81Abnormal EKG (HP:0003115)2.12949173
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12563442
83Hypoplasia of the brainstem (HP:0002365)2.12563442
84Abnormality of vitamin B metabolism (HP:0004340)2.11788875
85Torticollis (HP:0000473)2.07664431
86Hyperthyroidism (HP:0000836)2.07592879
87Impaired vibration sensation in the lower limbs (HP:0002166)2.07041536
88Cystic liver disease (HP:0006706)2.05240385
89Abnormal respiratory motile cilium morphology (HP:0005938)2.03816523
90Abnormal respiratory epithelium morphology (HP:0012253)2.03816523
91Neurofibrillary tangles (HP:0002185)2.03636802
92Molar tooth sign on MRI (HP:0002419)2.02971916
93Abnormality of midbrain morphology (HP:0002418)2.02971916
94Polyphagia (HP:0002591)2.02041455
95Prolonged QT interval (HP:0001657)2.01322294
96Cerebral inclusion bodies (HP:0100314)2.01078241
97Sleep apnea (HP:0010535)2.00466580
98Bundle branch block (HP:0011710)1.99183620
99Neuroendocrine neoplasm (HP:0100634)1.99035744
100Increased CSF protein (HP:0002922)1.96867914
101Spastic tetraplegia (HP:0002510)1.94562487
102Horizontal nystagmus (HP:0000666)1.93211371
103Atelectasis (HP:0100750)1.93035648
104Poor suck (HP:0002033)1.92950159
105Failure to thrive in infancy (HP:0001531)1.92882013
106Increased hepatocellular lipid droplets (HP:0006565)1.92808802
107Occipital encephalocele (HP:0002085)1.92364806
108Abnormality of the renal cortex (HP:0011035)1.92336486
109Inappropriate behavior (HP:0000719)1.91398079
110Abnormality of macular pigmentation (HP:0008002)1.91210047
111Postural tremor (HP:0002174)1.90909920
112Gaze-evoked nystagmus (HP:0000640)1.90159232
113Delusions (HP:0000746)1.89866626
114Lissencephaly (HP:0001339)1.89532929
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86854095
116Muscular hypotonia of the trunk (HP:0008936)1.85681596
117Choroideremia (HP:0001139)1.84957266
118Specific learning disability (HP:0001328)1.84154545
119Palpebral edema (HP:0100540)1.83957846
120Furrowed tongue (HP:0000221)1.83664322
121Growth hormone deficiency (HP:0000824)1.82523477
122Papilledema (HP:0001085)1.82430069
123Congenital primary aphakia (HP:0007707)1.82325059
124Abnormality of the corticospinal tract (HP:0002492)1.80614223
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.80275645
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80275645
127Incomplete penetrance (HP:0003829)1.77698581
128Abnormality of salivation (HP:0100755)1.77635323
129Postural instability (HP:0002172)1.75958497
130Metaphyseal dysplasia (HP:0100255)1.75852545
131Genital tract atresia (HP:0001827)1.75534767
132Pachygyria (HP:0001302)1.74417255
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.73212408
134Progressive macrocephaly (HP:0004481)1.72033855
135Lower limb muscle weakness (HP:0007340)1.71947245
136Heterochromia iridis (HP:0001100)1.71705007
137Sclerocornea (HP:0000647)1.71438673
138Syncope (HP:0001279)1.71370412
139Lower limb amyotrophy (HP:0007210)1.70762388
140Amyotrophic lateral sclerosis (HP:0007354)1.70244072
141Abnormal pancreas size (HP:0012094)1.69792783
1423-Methylglutaconic aciduria (HP:0003535)1.69770049
143Glycosuria (HP:0003076)1.69728838
144Abnormality of urine glucose concentration (HP:0011016)1.69728838
145Left ventricular hypertrophy (HP:0001712)1.69336715
146Aqueductal stenosis (HP:0002410)1.69035720
147Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68278625
148Impaired smooth pursuit (HP:0007772)1.66831076
149Generalized myoclonic seizures (HP:0002123)1.66318994
150Focal dystonia (HP:0004373)1.66296983
151Abnormality of vitamin metabolism (HP:0100508)1.66248301
152Optic nerve hypoplasia (HP:0000609)1.65962140
153Akinesia (HP:0002304)1.65498881
154Muscle hypertrophy of the lower extremities (HP:0008968)1.65162637
155Hemiplegia (HP:0002301)1.65136100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR24.58975006
2MARK14.20327722
3NTRK24.01757070
4TYRO33.85638397
5FGFR43.04399287
6NTRK32.85111839
7FRK2.79548215
8EPHA32.74658882
9EPHA42.57633242
10MINK12.40124132
11WNK32.36684028
12MAP4K22.35339716
13PDGFRA2.11114004
14MAP3K102.08937285
15MAP3K91.93373950
16GRK11.92282709
17MAP3K41.90554271
18MAP2K71.86244689
19PAK61.81307752
20CAMK2B1.81261638
21CASK1.77868983
22GRK71.76314051
23DAPK21.47377100
24DYRK1A1.47114014
25WNK41.44769462
26NTRK11.43675285
27SIK31.41718886
28FGFR31.40131560
29NME11.39372995
30ADRBK21.28756206
31SGK21.25708009
32PRPF4B1.24687888
33FES1.19984833
34RET1.19771969
35MAPK131.19312354
36CAMK2A1.18854728
37CAMK2D1.18233390
38CAMK2G1.17252906
39CDK51.14399482
40KSR11.13674611
41UHMK11.08814016
42LATS21.06457197
43MAP3K111.06248498
44MAP2K41.03503299
45RIPK41.02456397
46DDR20.99933443
47TNIK0.99598820
48PNCK0.99194127
49STK38L0.98056152
50PINK10.97897311
51PDK30.95967464
52PDK40.95967464
53TRIM280.95509782
54PHKG20.92860827
55PHKG10.92860827
56TIE10.88267156
57YES10.86958272
58STK380.85964338
59MAP3K120.85324869
60AKT30.84132065
61CDK190.81912643
62SGK10.79739894
63BCR0.76293261
64OXSR10.74616534
65PRKCG0.74493177
66PTK2B0.74182726
67KSR20.73408706
68CSNK1G20.72893439
69PLK20.72748634
70CDK180.72611222
71WNK10.71363857
72LIMK10.70801121
73CAMKK20.69591411
74SGK30.69241662
75MKNK20.68681263
76PRKCH0.68274546
77CDK140.68090307
78STK390.66927514
79NLK0.66724517
80STK110.66389922
81INSRR0.66313825
82CDK150.65515958
83MAPKAPK50.62910166
84GRK50.62832043
85FER0.62197954
86PAK30.59306432
87MAP2K60.56243937
88CAMKK10.55306555
89FGFR10.55298563
90PDGFRB0.53962834
91TRIB30.53753874
92PRKG10.52876031
93PRKCI0.52512401
94PKN10.52114652
95CDK11A0.51726516
96TAOK10.51572254
97SGK4940.51449756
98SGK2230.51449756
99OBSCN0.50970621
100ERBB30.50722704
101DAPK10.48988271
102PDPK10.48898577
103CAMK10.48737700
104ADRBK10.48647697
105CAMK1G0.48513888
106CSNK1G10.47835186
107PRKD30.47811714
108BMPR1B0.47197980
109PRKCE0.46570450
110PRKCZ0.46423885
111CSNK1A10.44863090
112FGR0.44576977
113DYRK30.44475873
114ROCK20.44204291
115PRKAA10.43796122
116PRKACB0.43786594
117PDK10.43571252
118DYRK20.43095530
119SRPK10.42745837
120CSNK1G30.42063302
121PRKD10.40888940
122ITK0.40860834
123MAPK150.40285335
124EPHB10.40245878
125PDK20.39576411
126SIK20.39418482
127SIK10.38129330
128IRAK20.37708740
129TNK20.37061561
130CAMK40.36760721
131CSNK1E0.36518378
132RPS6KA30.36018137
133PRKACA0.35752612
134ERBB20.35083376
135MAP2K10.34931991
136CSNK1D0.33896532
137FYN0.33365035
138EPHB20.32307142
139CSNK1A1L0.32284173
140PRKCA0.31548229
141MAP3K20.26612864
142MAP3K50.26133436

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.56962624
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06529519
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68182553
4Circadian entrainment_Homo sapiens_hsa047132.65359816
5GABAergic synapse_Homo sapiens_hsa047272.64502136
6Glutamatergic synapse_Homo sapiens_hsa047242.42581436
7Morphine addiction_Homo sapiens_hsa050322.39924333
8Dopaminergic synapse_Homo sapiens_hsa047282.22767810
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.11719187
10Serotonergic synapse_Homo sapiens_hsa047262.10239422
11Salivary secretion_Homo sapiens_hsa049702.00759226
12Cholinergic synapse_Homo sapiens_hsa047251.98198355
13Amphetamine addiction_Homo sapiens_hsa050311.96940627
14Olfactory transduction_Homo sapiens_hsa047401.96038581
15Insulin secretion_Homo sapiens_hsa049111.90533977
16Taste transduction_Homo sapiens_hsa047421.83487852
17Long-term potentiation_Homo sapiens_hsa047201.76605177
18Long-term depression_Homo sapiens_hsa047301.71154498
19Cocaine addiction_Homo sapiens_hsa050301.66064794
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65248617
21Vibrio cholerae infection_Homo sapiens_hsa051101.64197034
22Axon guidance_Homo sapiens_hsa043601.64160334
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57027529
24Collecting duct acid secretion_Homo sapiens_hsa049661.56718957
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53373211
26Renin secretion_Homo sapiens_hsa049241.48135418
27Parkinsons disease_Homo sapiens_hsa050121.46734771
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44468678
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41380558
30Phototransduction_Homo sapiens_hsa047441.41354742
31Calcium signaling pathway_Homo sapiens_hsa040201.41140747
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36749074
33Gap junction_Homo sapiens_hsa045401.33633089
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31680165
35Gastric acid secretion_Homo sapiens_hsa049711.29184565
36Oxytocin signaling pathway_Homo sapiens_hsa049211.29047740
37Protein export_Homo sapiens_hsa030601.28944458
38Ether lipid metabolism_Homo sapiens_hsa005651.27428327
39Vitamin B6 metabolism_Homo sapiens_hsa007501.26961836
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19401345
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17313622
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15247306
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13480003
44Steroid biosynthesis_Homo sapiens_hsa001001.13353288
45Histidine metabolism_Homo sapiens_hsa003401.11377356
46cAMP signaling pathway_Homo sapiens_hsa040241.11223316
47Glioma_Homo sapiens_hsa052141.09683387
48Estrogen signaling pathway_Homo sapiens_hsa049151.09250399
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08861187
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07757943
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07554341
52GnRH signaling pathway_Homo sapiens_hsa049121.04125699
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04051085
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03637829
55ErbB signaling pathway_Homo sapiens_hsa040121.02524829
56Folate biosynthesis_Homo sapiens_hsa007901.01387013
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92360573
58Circadian rhythm_Homo sapiens_hsa047100.92264047
59Melanogenesis_Homo sapiens_hsa049160.92010916
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.91904033
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90966713
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90143722
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88100671
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87184043
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85372314
66Linoleic acid metabolism_Homo sapiens_hsa005910.83887015
67Choline metabolism in cancer_Homo sapiens_hsa052310.82722869
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82682783
69Tryptophan metabolism_Homo sapiens_hsa003800.82151676
70Selenocompound metabolism_Homo sapiens_hsa004500.82023585
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80795481
72beta-Alanine metabolism_Homo sapiens_hsa004100.80018871
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79430519
74Huntingtons disease_Homo sapiens_hsa050160.77775370
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.76654732
76Dilated cardiomyopathy_Homo sapiens_hsa054140.75800270
77Propanoate metabolism_Homo sapiens_hsa006400.75502900
78Cardiac muscle contraction_Homo sapiens_hsa042600.75092533
79Pancreatic secretion_Homo sapiens_hsa049720.74303254
80Type II diabetes mellitus_Homo sapiens_hsa049300.73476107
81Ras signaling pathway_Homo sapiens_hsa040140.71752170
82VEGF signaling pathway_Homo sapiens_hsa043700.70373088
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.70124164
84Butanoate metabolism_Homo sapiens_hsa006500.68567714
85Regulation of autophagy_Homo sapiens_hsa041400.66440677
86Sulfur metabolism_Homo sapiens_hsa009200.65909918
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65048870
88Rap1 signaling pathway_Homo sapiens_hsa040150.64512605
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63542478
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63033000
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62745089
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59390687
93ABC transporters_Homo sapiens_hsa020100.58987649
94Thyroid hormone synthesis_Homo sapiens_hsa049180.57737056
95MAPK signaling pathway_Homo sapiens_hsa040100.56844233
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56644833
97Bile secretion_Homo sapiens_hsa049760.56572541
98Sphingolipid metabolism_Homo sapiens_hsa006000.53776260
99Alcoholism_Homo sapiens_hsa050340.53262550
100Glucagon signaling pathway_Homo sapiens_hsa049220.52846336
101Arginine biosynthesis_Homo sapiens_hsa002200.52173633
102Nitrogen metabolism_Homo sapiens_hsa009100.50687467
103Hedgehog signaling pathway_Homo sapiens_hsa043400.49917102
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49817225
105Inositol phosphate metabolism_Homo sapiens_hsa005620.48335104
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47895703
107Oxidative phosphorylation_Homo sapiens_hsa001900.47806014
108Wnt signaling pathway_Homo sapiens_hsa043100.46739496
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46506662
110Ovarian steroidogenesis_Homo sapiens_hsa049130.44449352
111Tight junction_Homo sapiens_hsa045300.43795377
112Alzheimers disease_Homo sapiens_hsa050100.43773765
113Mineral absorption_Homo sapiens_hsa049780.43584990
114Peroxisome_Homo sapiens_hsa041460.42990226
115Dorso-ventral axis formation_Homo sapiens_hsa043200.42843149
116African trypanosomiasis_Homo sapiens_hsa051430.42705352
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40475557
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39271258
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.37682683
120AMPK signaling pathway_Homo sapiens_hsa041520.37295640
121Rheumatoid arthritis_Homo sapiens_hsa053230.36609824
122Glycerolipid metabolism_Homo sapiens_hsa005610.36117795
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35524180
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33469060
125Fatty acid biosynthesis_Homo sapiens_hsa000610.31651171
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31435227
127Renal cell carcinoma_Homo sapiens_hsa052110.31368437
128Non-small cell lung cancer_Homo sapiens_hsa052230.30382351
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29662740
130Fatty acid elongation_Homo sapiens_hsa000620.28177475
131Oocyte meiosis_Homo sapiens_hsa041140.28137146
132Melanoma_Homo sapiens_hsa052180.28096424
133Phagosome_Homo sapiens_hsa041450.27680321
134Endocytosis_Homo sapiens_hsa041440.27077842

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